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IUBMB CommentsA pyridoxal-phosphate protein. Can use a second molecule of cysteine (producing lanthionine), or other alkyl thiols, as a replacing agent.
The enzyme appears in viruses and cellular organisms
Synonyms
cysteine lyase,
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lyase, cysteine (sulfite)
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L-cysteine + sulfite = L-cysteate + hydrogen sulfide
L-cysteine + sulfite = L-cysteate + hydrogen sulfide
beta-replacement reaction
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L-cysteine + sulfite = L-cysteate + hydrogen sulfide
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elimination
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of H2S or RSH, C-S bond cleavage
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L-cysteine hydrogen-sulfide-lyase (adding sulfite; L-cysteate-forming)
A pyridoxal-phosphate protein. Can use a second molecule of cysteine (producing lanthionine), or other alkyl thiols, as a replacing agent.
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L-Cys + 2-mercaptoethanol
S-(2-hydroxyethyl)cysteine + ?
L-Cys + 3-mercaptopropionate
?
L-Cys + cysteamine
S-(2-amino-2-carboxyethyl)cysteine + ?
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?
L-Cys + dithiothreitol
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?
L-Cys + ethanethiol
?
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?
L-Cys + L-Cys
lanthionine
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?
L-Cys + methanethiol
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?
L-Cys + sulfite
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production of L-cysteate, the precursor of the fetal metabolite taurine
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?
L-Cys + sulfite
L-cysteate + H2S
L-Cys + 2-mercaptoethanol
S-(2-hydroxyethyl)cysteine + ?
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?
L-Cys + 2-mercaptoethanol
S-(2-hydroxyethyl)cysteine + ?
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?
L-Cys + 3-mercaptopropionate
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?
L-Cys + 3-mercaptopropionate
?
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weak
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?
L-Cys + sulfite
L-cysteate + H2S
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?
L-Cys + sulfite
L-cysteate + H2S
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?
L-Cys + sulfite
L-cysteate + H2S
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?
L-Cys + thioglycolate
?
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?
L-Cys + thioglycolate
?
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weak
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?
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L-Cys + sulfite
?
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production of L-cysteate, the precursor of the fetal metabolite taurine
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?
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pyridoxal 5'-phosphate
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dependent
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additional information
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no inhibition by: 20 mM L-Cys, 20 mM penicillamine, 20 mM cysteamine, 20 mM cycloserine
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7.7
2-mercaptoethanol
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bat
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brenda
batrachian
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brenda
Callopanchax sp.
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brenda
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brenda
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brenda
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brenda
Epiplatys sp.
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brenda
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brenda
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brenda
Turtle
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brenda
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batrachian
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of the ventral endoderm, tail-bud stage
brenda
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yolk-sac
brenda
Callopanchax sp.
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brenda
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brenda
Epiplatys sp.
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brenda
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brenda
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brenda
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brenda
Turtle
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brenda
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Braunstein, A.E.; Goryachenkova, E.V.
The beta-replacement-specific pyridoxal-P-dependent lyases
Adv. Enzymol. Relat. Areas Mol. Biol.
56
1-89
1984
Gallus gallus
brenda
Fischer, J.L.; Smith, J.; Chapeville, F.; Dubois, R.
La localisation de la cysteine lyase et le plan d'organisation du developpement embryonnaire chez divers repronsentabts de vertebres
Biol. Cell.
46
291-300
1982
bat, batrachian, Chamaeleo sp., Gallus gallus, Elasmobranchii, Epiplatys sp., Rivulus sp., Callopanchax sp., Turtle, Caudata
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brenda
Braunstein, A.E.; Goryachenkova, E.V.
The pyridoxal-phosphate-dependent enzymes exclusively catalyzing reactions of beta-replacement
Biochimie
58
5-17
1976
Gallus gallus
brenda
Tolosa, E.A.; Chepurnova, N.K.; Khomutov, R.M.; Severin, E.S.
Reactions catalysed by cysteine lyase from the yolk sac of chicken embryo
Biochim. Biophys. Acta
171
369-371
1969
Gallus gallus
brenda
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