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Abscess
Enzymatically active Peptostreptococcus magnus: association with site of infection.
Acidosis
Downregulation in the expression of the serine dehydratase in the rat liver during chronic metabolic acidosis.
Acidosis
Localization and hormonal control of serine dehydratase during metabolic acidosis differ markedly from those of phosphoenolpyruvate carboxykinase in rat kidney.
Carcinoma
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma.
Carcinoma, Hepatocellular
Effect of B6 deficiency on hepatoma 7794A growth rate: activities of tyrosine transaminase and serine dehydratase before and after induction by hydrocortisone.
Carcinoma, Hepatocellular
Effect of pyridoxine availability on the activity of serine dehydratase of normal liver, host liver, and three Morris hepatomas.
Carcinoma, Hepatocellular
Expression of only one of two types of mRNA transcribed from the serine dehydratase gene is repressed in hepatoma cells.
Carcinoma, Hepatocellular
Hormonal and nutritional effects on the binding of 125I-labeled anti-serine dehydratase Fab' to rat tissue polysomes.
Carcinoma, Hepatocellular
Metabolic adaptations in rat hepatomas: altered regulation of serine dehydratase synthesis by glucose and amino acids in hepatocellular carcinomas.
Dehydration
A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies.
Dehydration
Crystal structure of serine dehydratase from rat liver.
Dehydration
Hydrogen-Deuterium Exchange Mass Spectrometry Reveals Unique Conformational and Chemical Transformations Occurring upon [4Fe-4S] Cluster Binding in the Type 2 l-Serine Dehydratase from Legionella pneumophila.
Diabetes Mellitus
Periportal expression of the serine dehydratase gene in rat liver.
Diabetes Mellitus
Regulation of the expression of the serine dehydratase gene in the kidney and liver of the rat.
Diabetic Foot
Enzymatically active Peptostreptococcus magnus: association with site of infection.
Fragile X Syndrome
Identification of distinct genes with restricted expression in the somitic mesoderm in Xenopus embryo.
Hepatitis
[The activity of serine dehydratase enzyme of liver tissue in experimental murine infection with mouse hepatitis virus 3]
Hyperinsulinism
Effects of insulin, epinephrine, and glucose on regulation of transcription of the serine dehydratase gene in newborn dogs.
Hypersensitivity
Nutritional regulation and tissue-specific expression of the serine dehydratase gene in rat.
Hypersensitivity
Threonine deaminase from Escherichia coli: feedback-hypersensitive enzyme from a genetic regulatory mutant.
Infections
Enzymatically active Peptostreptococcus magnus: association with site of infection.
Infections
[The activity of serine dehydratase enzyme of liver tissue in experimental murine infection with mouse hepatitis virus 3]
Intellectual Disability
Identification of distinct genes with restricted expression in the somitic mesoderm in Xenopus embryo.
Leukemia
L-Threonine deaminase as a possible antitumor agent.
Neoplasms
A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies.
Neoplasms
Enzymes of serine metabolism in normal and neoplastic rat tissues.
Neoplasms
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma.
Neoplasms
Induction of enzymes by glucagon, glucose repression, adenosine 3',5'-monophosphate concentration during carcinogenesis and in Morris 6918A hepatoma.
Sarcoma
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma.
Starvation
Amino acid metabolism enzyme activities in the obese Zucker rat.
Starvation
Control of hepatic utilization of serine, glycine and threonine in fed and starved rats.
Starvation
Distribution of amino acids and amino-acid enzymes in whole kidney and renal cortex. Effect of 24-h starvation.
Starvation
Effects of glucose, insulin, and cAMP on transcription of the serine dehydratase gene in rat liver.
Starvation
Regulation of the expression of the serine dehydratase gene in the kidney and liver of the rat.
Starvation
Serine dehydratase and tyrosine aminotransferase activities increased by long-term starvation and recovery by refeeding in rainbow trout (Oncorhynchus mykiss).
Starvation
Synthesis of inducible enzyme in Escherichia coli recovering from prolonged energy starvation.
Starvation
The regulation of serine dehydratase and glucose-6-phosphatase in hyperplastic nodules of rat liver during diethylnitrosamine and N-2-fluorenylacetamide feeding.
Tuberculosis
Kinetic Evidence of a Noncatalytic Substrate Binding Site That Regulates Activity in Legionella pneumophilal-Serine Dehydratase.
Tuberculosis
Kinetic, mutagenic, and structural homology analysis of L-serine dehydratase from Legionella pneumophila.
Tuberculosis
Loop-mediated isothermal amplification as alternative to PCR for the diagnosis of extra-pulmonary tuberculosis.
Tuberculosis
Structure of L-serine dehydratase from Legionella pneumophila: novel use of the C-terminal cysteine as an intrinsic competitive inhibitor.
Vitamin B 12 Deficiency
Vitamin B12 deficiency results in the abnormal regulation of serine dehydratase and tyrosine aminotransferase activities correlated with impairment of the adenylyl cyclase system in rat liver.
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0.49
L-serine O-sulfate
pH 8.0, 37°C, presence of 1 mM ATP, elimination reaction
130
L-Thr
-
in presence and in absence of 20 mM NH4Cl
additional information
additional information
-
-
-
3.2
D-serine
pH 8.0, 37°C, presence of 1 mM ATP, elimination reaction
8.5
D-serine
-
wild-type, alpha,beta-elimination, pH 7.4, 37°C
9
D-serine
-
wild-type, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C
12
D-serine
-
mutant Q155D, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C
14.5
D-serine
pH 8.0, 37°C, presence of 1 mM ATP, racemization reaction
49
D-serine
pH 8.0, 37°C, racemization reaction
75
D-serine
pH 8.0, 37°C, elimination reaction
55
D-threonine
-
wild-type, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C
60
D-threonine
-
mutant Q155D, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C
0.8
L-Ser
-
-
2
L-Ser
wild-type, pH 7.0, temperature not specified in the publication
2.2
L-Ser
mutant C183A, pH 7.0, temperature not specified in the publication
2.7
L-Ser
mutant C226A, pH 7.0, temperature not specified in the publication
3
L-Ser
mutant C221A, pH 7.0, temperature not specified in the publication
6.9
L-Ser
mutant C458A, pH 7.0, temperature not specified in the publication
7.8
L-Ser
Clostridium acidi-urici
-
-
17.8
L-Ser
mutant C304A, pH 7.0, temperature not specified in the publication
75
L-Ser
-
in presence of 20 mM NH4Cl
0.00258
L-serine
pH 7, temperature not specified in the publication, Vmax: 11.7/min/mg
1.7
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme T57A
2
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme S17A
2
L-serine
pH 7.0, temperature not specified in the publication, native enzyme
2.3
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme E457A
2.67
L-serine
-
pH 8.0, 37°C
3 - 3.2
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme H124A/N126A
3.1
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme T290A
3.5
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme S53A
3.8
L-serine
pH 8.0, 37°C, presence of 1 mM ATP, racemization reaction
4
L-serine
pH 8.0, 37°C, presence of 1 mM ATP, elimination reaction
4.3
L-serine
-
pH 7, temperature not specified in the publication
4.7
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme T20A
4.8
L-serine
-
anaerobically isolated enzyme, pH 8.0
5.1
L-serine
-
51°C, pH 7.6
5.1
L-serine
pH 7, temperature not specified in the publication
6.9
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme C458A
9
L-serine
-
wild-type, alpha,beta-elimination, pH 7.4, 37°C
10
L-serine
-
wild-type, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C
10.6
L-serine
-
pH 7, temperature not specified in the publication
11
L-serine
-
mutant Q155D, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C
13.6
L-serine
-
pH 7, temperature not specified in the publication, 100 mM KCl
24.4
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme H19A
25.5
L-serine
-
pH 7, temperature not specified in the publication, 300 mM KCl
29.2
L-serine
-
pH 7, temperature not specified in the publication, 500 mM KCl
30
L-serine
pH 8.0, 37°C, racemization reaction
45
L-serine
-
pH 8.3, 37°C
67
L-serine
-
37°C, pH 8.3, recombinant SDH
75
L-serine
pH 8.0, 37°C, elimination reaction
158.8
L-serine
-
effect of chronic acidosis
177
L-serine
-
pH 7.4, 25°C
182
L-serine
-
pH 7.4, 25°C, animals treated with thioacetamide for 97 days
189
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme T446A
0.5
L-threonine
-
-
50
L-threonine
-
37°C, pH 8.3, recombinant SDH
57
L-threonine
-
pH 8.3, 37°C
57
L-threonine
pH 8.3, 37°C
30.7
serine
cSDH L287V
3.1
threonine
cSDH
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2.6
beta-chloro-L-alanine
pH 8.0, 37°C, presence of 1 mM ATP, elimination reaction
0.49
L-serine O-sulfate
pH 8.0, 37°C, presence of 1 mM ATP, elimination reaction
31
L-threo-3-hydroxyaspartate
pH 8.0, 37°C, presence of 1 mM ATP, elimination reaction
0.0033
D-serine
-
wild-type, pH 7.4, 37°C
0.012
D-serine
-
mutant Q155D, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C
0.042
D-serine
-
wild-type, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C
3.2
D-serine
pH 8.0, 37°C, presence of 1 mM ATP, elimination reaction
14.5
D-serine
pH 8.0, 37°C, presence of 1 mM ATP, racemization reaction
0.028
D-threonine
-
mutant Q155D, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C
0.3
D-threonine
-
wild-type, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C
323
L-Ser
mutant C304A, pH 7.0, temperature not specified in the publication
330
L-Ser
wild-type, pH 7.0, temperature not specified in the publication
359
L-Ser
mutant C221A, pH 7.0, temperature not specified in the publication
467
L-Ser
mutant C226A, pH 7.0, temperature not specified in the publication
506
L-Ser
mutant C183A, pH 7.0, temperature not specified in the publication
512
L-Ser
mutant C458A, pH 7.0, temperature not specified in the publication
0.033
L-serine
-
mutant Q155D, presence of ATP, pH 7.4, 37°C
0.033
L-serine
-
wild-type, alpha,beta-elimination, pH 7.4, 37°C
0.166
L-serine
-
wild-type, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C
3.8
L-serine
pH 8.0, 37°C, presence of 1 mM ATP, racemization reaction
4
L-serine
pH 8.0, 37°C, presence of 1 mM ATP, elimination reaction
4.07
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme T290A
8.8
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme T57A
12
L-serine
-
pH 7, temperature not specified in the publication
31
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme H19A
67
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme S17A
112
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme H124A/N126A
181
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme T20A
184
L-serine
-
pH 7, temperature not specified in the publication, 100 mM KCl
201
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme S53A
249
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme E457A
286
L-serine
pH 7, temperature not specified in the publication
330
L-serine
pH 7.0, temperature not specified in the publication, native enzyme
356
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme T446A
436
L-serine
-
pH 8.0, 37°C
465
L-serine
-
pH 7, temperature not specified in the publication, 300 mM KCl
512
L-serine
pH 7.0, temperature not specified in the publication, mutant enzyme C458A
544
L-serine
-
anaerobically isolated enzyme, pH 8.0
585
L-serine
-
pH 7, temperature not specified in the publication, 500 mM KCl
5.2
L-threonine
-
10.5
L-threonine
pH 8.0, 37°C, presence of 1 mM ATP, elimination reaction
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Porter, P.N.; Grishaver, M.S.; Jones, O.W.
Characterization of human cystathionine beta-synthase. Evidence for the identity of human L-serine dehydratase and cystathionine beta-synthase
Biochim. Biophys. Acta
364
128-139
1974
Homo sapiens
brenda
Farias, M.E.; Strasser de Saad, A.M.; Pesce de Ruiz Holgado, A.A.; Oliver, G.
Evidence for the presence of L-serine dehydratase in Lactobacillus murinus
J. Gen. Appl. Microbiol.
31
563-567
1985
Ligilactobacillus murinus, Ligilactobacillus murinus CNRZ 313
-
brenda
Newman, E.B.; Kapoor, V.
In vitro studies on L-serine deaminase activity of Escherichia coli K12
Can. J. Biochem.
58
1292-1297
1980
Escherichia coli
brenda
Yeung, Y.G.; Yeung, D.
Comparative studies on threonine and serine dehydratases in rat liver
Int. J. Biochem.
11
161-164
1980
Rattus norvegicus
brenda
Gannon, F.; Bridgeland, E.S.; Jones, K.M.
L-Serine dehydratase from Arthrobacter globiformis
Biochem. J.
161
345-355
1977
Arthrobacter globiformis
brenda
Gannon, F.; Jones, K.M.
An activity stain for L-serine dehydratase in polyacrylamide gels
Anal. Biochem.
79
594-596
1977
Arthrobacter globiformis
brenda
Grillo, M.A.
Serine dehydratase in animal tissues
Acta Vitaminol. Enzymol.
27
51-61
1973
Gallus gallus, Rattus norvegicus
brenda
Morikawa, Y.; Nakamura, N.; Kimura, K.
Purification and some properties of L-serine dehydratase of Corynebacterium sp.
Agric. Biol. Chem.
38
531-537
1974
Corynebacterium sp.
-
brenda
Isenberg, S.; Newman, E.B.
Studies on L-serine deaminase in Escherichia coli K-12
J. Bacteriol.
118
53-58
1974
Escherichia coli
brenda
Simon, D.; Kroeger, H.
Interactions of L-serine dehydratase from rat liver with its coenzyme and substrates
Biochim. Biophys. Acta
334
208-217
1974
Rattus norvegicus
-
brenda
Simon, D.; Hoshino, J.; Kroeger, H.
L-Serine dehydratase from rat liver. Purification and some properties
Biochim. Biophys. Acta
321
361-368
1973
Rattus norvegicus
brenda
Hoshino, J.; Simon, D.; Kroeger, H.
Influence of monovalent cations on the activity of L-serine (L-threonine) dehydratase from rat liver
Eur. J. Biochem.
27
388-394
1972
Rattus norvegicus
brenda
Sagers, R.D.; Carter, J.E.
L-Serine dehydratase (Clostridium acidiurici)
Methods Enzymol.
17B
351-356
1971
Clostridium acidi-urici
-
brenda
Pestana, A.; Sandoval, I.V.; Sols, A.
Inhibition by homocysteine of serine dehydratase and other pyridoxal 5'-phosphate enzymes of the rat through cofactor blockage
Arch. Biochem. Biophys.
146
373-379
1971
Rattus norvegicus
brenda
Kubota, K.; Yokozeki, K.; Ozaki, H.
Effect of L-serine dehydratase activity onL-serine production by Corynebacterium glycinophilum and an examination of the properties of the enzyme
J. Ferment. Bioeng.
67
391-394
1989
Corynebacterium glyciniphilum, Corynebacterium glyciniphilum AJ-3170
-
brenda
Farias, M.E.; Strasser de Saad, A.M.; Pesce de Ruiz Holgado, A.A.; Oliver, G.
Purification and properties of L-serine dehydratase from Lactobacillus fermentum ATCC 14931
Curr. Microbiol.
22
205-211
1991
Limosilactobacillus fermentum
-
brenda
Grabowski, R.; Hofmeister, A.E.M.; Buckel, W.
Bacterial L-serine dehydratases: a new family of enzymes containing iron-sulfur clusters
Trends Biochem. Sci.
18
297-300
1993
Klebsiella aerogenes, Arthrobacter globiformis, Burkholderia cepacia, Clostridium acidi-urici, Escherichia coli, Limosilactobacillus fermentum, Peptoniphilus asaccharolyticus
brenda
Zinecker, H.; Andreesen, J.R.; Pich, A.
Partial purification of an iron-dependent L-serine dehydratase from Clostridium sticklandii
J. Basic Microbiol.
38
147-155
1998
Acetoanaerobium sticklandii
brenda
Hofmeister, A.E.M.; Grabowski, R.; Linder, D.; Buckel, W.
L-Serine and L-threonine dehydratase from Clostridium propionicum. Two enzymes with different prosthetic groups
Eur. J. Biochem.
215
341-349
1993
Anaerotignum propionicum
brenda
Hofmeister, A.E.M.; Albracht, S.P.J.; Buckel, W.
Iron-sulfur cluster-containing L-serine dehydratase from Peptostreptococcus asaccharolyticus: correlation of the cluster type with enzymatic activity
FEBS Lett.
351
416-418
1994
Peptoniphilus asaccharolyticus
brenda
Grabowski, R.; Buckel, W.
Purification and properties of an iron-sulfur containing and pyridoxal-phosphate-independent L-serine dehydratase from Peptostreptococcus asaccharolyticus
Eur. J. Biochem.
199
89-94
1991
Peptoniphilus asaccharolyticus
brenda
Su, H.; Moniakis, J.; Newman, E.B.
Use of gene fusion of the structural gene sdaA to purify L-serine deaminase 1 from Escherichia coli K-12
Eur. J. Biochem.
211
521-527
1993
Escherichia coli
brenda
Newman, E.B.; Walker, C.; Ziegler-Skylakis, K.
A possible mechanism for the in vitro activation of L-serine deaminase activity in Escherichia coli K12
Biochem. Cell Biol.
68
723-728
1990
Escherichia coli
brenda
Hopgood, M.F.; Ballard, F.J.
The relative stability of liver cytosol enzymes incubated in vitro
Biochem. J.
144
371-376
1974
Rattus norvegicus
brenda
Ramos, F.; Wiame, J.M.
Occurrence of a catabolic L-serine (L-threonine) deaminase in Saccharomyces cerevisiae
Eur. J. Biochem.
123
571-576
1982
Saccharomyces cerevisiae
brenda
Suda, M.; Nakagawa, H.
L-Serine dehydratase (rat liver)
Methods Enzymol.
17B
346-351
1971
Rattus norvegicus
-
brenda
Ogawa, H.; Takasugawa, F.; Wakaki, K.; Kishi, H.; Eskandarian, M.R.; Kobayashi, M.; Date, T.; Huh, N.H.; Pitot, H.C.
Rat liver serine dehydratase. Bacterial expression and two folding domains as revealed by limited proteolysis
J. Biol. Chem.
274
12855-12860
1999
Rattus norvegicus
brenda
Sun, L.; Li, X.; Dong, Y.; Yang, M.; Liu, Y.; Han, X.; Zhang, X.; Pang, H.; Rao, Z.
Crystallization and preliminary crystallographic analysis of human serine dehydratase
Acta Crystallogr. Sect. D
59
2297-2299
2003
Homo sapiens
brenda
Yamada, T.; Komoto, J.; Takata, Y.; Ogawa, H.; Pitot, H.C.; Takusagawa, F.
Crystal structure of serine dehydratase from rat liver
Biochemistry
42
12854-12865
2003
Rattus norvegicus (P09367)
brenda
Imai, S.; Kanamoto, R.; Yagi, I.; Kotaru, M.; Saeki, T.; Iwami, K.
Response of the induction of rat liver serine dehydratase to changes in the dietary protein requirement
Biosci. Biotechnol. Biochem.
67
383-387
2003
Rattus norvegicus
brenda
Laroche, M.; Pukall, R.; Ulber, R.
Recovery and characterization of a L-serine dehydratase from the marine bacterium Paracoccus seriniphilus for the construction of bioanalytical systems
Chem. -Ing. -Tech.
75
146-149
2003
Paracoccus seriniphilus
-
brenda
Velayudhan, J.; Jones, M.A.; Barrow, P.A.; Kelly, D.J.
L-serine catabolism via an oxygen-labile L-serine dehydratase is essential for colonization of the avian gut by Campylobacter jejuni
Infect. Immun.
72
260-268
2004
Campylobacter jejuni
brenda
Ogawa, H.; Gomi, T.; Takusagawa, F.; Masuda, T.; Goto, T.; Kan, T.; Huh, N.H.
Evidence for a dimeric structure of rat liver serine dehydratase
Int. J. Biochem. Cell Biol.
34
533-543
2002
Ovis aries, Rattus norvegicus
brenda
Xue, H.H.; Fujie, M.; Sakaguchi, T.; Oda, T.; Ogawa, H.; Kneer, N.M.; Lardy, H.A.; Ichiyama, A.
Flux of the L-serine metabolism in rat liver. The predominant contribution of serine dehydratase
J. Biol. Chem.
274
16020-16027
1999
Rattus norvegicus
brenda
Strisovsky, K.; Jiraskova, J.; Mikulova, A.; Rulisek, L.; Konvalinka, J.
Dual substrate and reaction specificity in mouse serine racemase: identification of high-affinity dicarboxylate substrate and inhibitors and analysis of the beta-eliminase activity
Biochemistry
44
13091-13100
2005
Mus musculus (Q9QZX7)
brenda
Strisovsky, K.; Jiraskova, J.; Barinka, C.; Majer, P.; Rojas, C.; Slusher, B.S.; Konvalinka, J.
Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate
FEBS Lett.
535
44-48
2003
Mus musculus (Q9QZX7)
brenda
Foltyn, V.N.; Bendikov, I.; De Miranda, J.; Panizzutti, R.; Dumin, E.; Shleper, M.; Li, P.; Toney, M.D.; Kartvelishvily, E.; Wolosker, H.
Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity
J. Biol. Chem.
280
1754-1763
2005
Mus musculus
brenda
Neidle, A.; Dunlop, D.S.
Allosteric regulation of mouse brain serine racemase
Neurochem. Res.
27
1719-1724
2002
Mus musculus
brenda
Nagayoshi, C.; Ishibashi, M.; Kita, Y.; Matsuoka, M.; Nishimoto, I.; Tokunaga, M.
Expression, refolding and characterization of human brain serine racemase in Escherichia coli with N-terminal His-tag
Protein Pept. Lett.
12
487-490
2005
Homo sapiens
brenda
Kanamoto, R.; Fujita, K.; Kumasaki, M.; Imai, S.; Kotaru, M.; Saeki, T.; Iwami, K.
Inverse correlation between the nitrogen balance and induction of rat liver serine dehydratase (SDH) by dietary protein
Biosci. Biotechnol. Biochem.
68
888-893
2004
Rattus norvegicus
brenda
Burman, J.D.; Harris, R.L.; Hauton, K.A.; Lawson, D.M.; Sawers, R.G.
The iron-sulfur cluster in the L-serine dehydratase TdcG from Escherichia coli is required for enzyme activity
FEBS Lett.
576
442-444
2004
Escherichia coli
brenda
Kashii, T.; Gomi, T.; Oya, T.; Ishii, Y.; Oda, H.; Maruyama, M.; Kobayashi, M.; Masuda, T.; Yamazaki, M.; Nagata, T.; Tsukada, K.; Nakajima, A.; Tatsu, K.; Mori, H.; Takusagawa, F.; Ogawa, H.; Pitot, H.C.
Some biochemical and histochemical properties of human liver serine dehydratase
Int. J. Biochem. Cell Biol.
37
574-589
2005
Rattus norvegicus, Homo sapiens (P20132), Homo sapiens
brenda
Cicchillo, R.M.; Baker, M.A.; Schnitzer, E.J.; Newman, E.B.; Krebs, C.; Booker, S.J.
Escherichia coli L-serine deaminase requires a [4Fe-4S] cluster in catalysis
J. Biol. Chem.
279
32418-32425
2004
Escherichia coli
brenda
Lopez-Flores, I.; Barroso, J.B.; Valderrama, R.; Esteban, F.J.; Martinez-Lara, E.; Luque, F.; Peinado, M.A.; Ogawa, H.; Lupianez, J.A.; Peragon, J.
Serine dehydratase expression decreases in rat livers injured by chronic thioacetamide ingestion
Mol. Cell. Biochem.
268
33-43
2005
Rattus norvegicus
brenda
Sun, L.; Bartlam, M.; Liu, Y.; Pang, H.; Rao, Z.
Crystal structure of the pyridoxal-5'-phosphate-dependent serine dehydratase from human liver
Protein Sci.
14
791-798
2005
Homo sapiens
brenda
Lopez-Flores, I.; Peragon, J.; Valderrama, R.; Esteban, F.J.; Luque, F.; Peinado, M.A.; Aranda, F.; Lupianez, J.A.; Barroso, J.B.
Downregulation in the expression of the serine dehydratase in the rat liver during chronic metabolic acidosis
Am. J. Physiol.
291
R1295-R1302
2006
Rattus norvegicus
brenda
Ogawa, H.; Gomi, T.; Nishizawa, M.; Hayakawa, Y.; Endo, S.; Hayashi, K.; Ochiai, H.; Takusagawa, F.; Pitot, H.C.; Mori, H.; Sakurai, H.; Koizumi, K.; Saiki, I.; Oda, H.; Fujishita, T.; Miwa, T.; Maruyama, M.; Kobayashi, M.
Enzymatic and biochemical properties of a novel human serine dehydratase isoform
Biochim. Biophys. Acta
1764
961-971
2006
Homo sapiens (P20132), Homo sapiens
brenda
Zhong, B.; Sakai, S.; Saeki, T.; Kanamoto, R.
Excess leucine intake induces serine dehydratase in rat liver
Biosci. Biotechnol. Biochem.
71
2614-2617
2007
Rattus norvegicus (P09367)
brenda
Anfora, A.T.; Haugen, B.J.; Roesch, P.; Redford, P.; Welch, R.A.
Roles of serine accumulation and catabolism in the colonization of the murine urinary tract by Escherichia coli CFT073
Infect. Immun.
75
5298-5304
2007
Escherichia coli
brenda
Elzainy, T.A.; Hassan, M.M.; Ali, T.H.
Occurrence of L-serine (L-threonine) deaminating enzyme in filamentous fungi
J. Biol. Sci.
6
564-571
2006
Aspergillus niger, Aspergillus terreus, Aspergillus terricola, Aspergillus niger NRRL 3
-
brenda
Elzainy, T.A.; Hassan, M.M.; Ali, T.H.
Occurrence of L-serine (L-threonine) deaminating enzyme in filamentous fungi
J. Biol. Sci. (Faisalabad)
6
564-571
2006
Penicillium palitans, Penicillium palitans NRC 510
-
brenda
Yamada, T.; Komoto, J.; Kasuya, T.; Takata, Y.; Ogawa, H.; Mori, H.; Takusagawa, F.
A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies
Biochim. Biophys. Acta
1780
809-818
2008
Homo sapiens (Q96GA7), Homo sapiens
brenda
Risso, C.; Van Dien, S.J.; Orloff, A.; Lovley, D.R.; Coppi, M.V.
Elucidation of an alternate isoleucine biosynthesis pathway in Geobacter sulfurreducens
J. Bacteriol.
190
2266-2274
2008
Geobacter sulfurreducens, Geobacter sulfurreducens DSM 12127
brenda
Zhao, Z.; Liu, H.
A quantum mechanical/molecular mechanical study on the catalysis of the pyridoxal 5'-phosphate-dependent enzyme L-serine dehydratase
J. Phys. Chem. B
112
13091-13100
2008
Rattus norvegicus (P09367)
brenda
Zhang, X.; Newman, E.
Deficiency in L-serine deaminase results in abnormal growth and cell division of Escherichia coli K-12
Mol. Microbiol.
69
870-881
2008
Escherichia coli K-12
brenda
Husain, A.; Jeelani, G.; Sato, D.; Ali, V.; Nozaki, T.
Characterization of two isotypes of L-threonine dehydratase from Entamoeba histolytica
Mol. Biochem. Parasitol.
170
100-104
2010
Entamoeba histolytica (B1N2N4), Entamoeba histolytica
brenda
Xu, X.L.; Chen, S.; Grant, G.A.
Kinetic, mutagenic, and structural homology analysis of L-serine dehydratase from Legionella pneumophila
Arch. Biochem. Biophys.
515
28-36
2011
Legionella pneumophila (Q5ZXE1), Legionella pneumophila
brenda
Zhang, X.; El-Hajj, Z.W.; Newman, E.
Deficiency in L-serine deaminase interferes with one-carbon metabolism and cell wall synthesis in Escherichia coli K-12
J. Bacteriol.
192
5515-5525
2010
Escherichia coli (P16095), Escherichia coli (P30744), Escherichia coli (P42630), Escherichia coli
brenda
Wang, C.Y.; Ku, S.C.; Lee, C.C.; Wang, A.H.
Modulating the function of human serine racemase and human serine dehydratase by protein engineering
Protein Eng. Des. Sel.
25
741-749
2012
Homo sapiens (P20132), Homo sapiens
brenda
Chen, S.; Xu, X.L.; Grant, G.A.
Allosteric activation and contrasting properties of L-serine dehydratase types 1 and 2
Biochemistry
51
5320-5328
2012
Bacillus subtilis, Legionella pneumophila (Q5ZXE1), Legionella pneumophila
brenda
Grant, G.A.
Kinetic evidence of a noncatalytic substrate binding site that regulates activity in Legionella pneumophila L-serine dehydratase
Biochemistry
51
6961-6967
2012
Legionella pneumophila
brenda
Rybniker, J.; Krumbach, K.; van Gumpel, E.; Plum, G.; Eggeling, L.; Hartmann, P.
The cytotoxic early protein 77 of mycobacteriophage L5 interacts with MSMEG_3532, an L-serine dehydratase of Mycobacterium smegmatis
J. Basic Microbiol.
51
515-522
2011
Mycolicibacterium smegmatis (A0QY48), Mycolicibacterium smegmatis
brenda
Qin, Z.; Yan, Q.; Ma, Q.; Jiang, Z.
Crystal structure and characterization of a novel L-serine ammonia-lyase from Rhizomucor miehei
Biochem. Biophys. Res. Commun.
466
431-437
2015
Rhizomucor miehei (A0A0X1KHE6), Rhizomucor miehei, Rhizomucor miehei CAU432 (A0A0X1KHE6)
brenda
Fujino, A.; Ose, T.; Yao, M.; Tokiwano, T.; Honma, M.; Watanabe, N.; Tanaka, I.
Structural and enzymatic properties of 1-aminocyclopropane-1-carboxylate deaminase homologue from Pyrococcus horikoshii
J. Mol. Biol.
341
999-1013
2004
Pyrococcus horikoshii (O57809)
brenda
Xu, X.L.; Grant, G.A.
Mutagenic and chemical analyses provide new insight into enzyme activation and mechanism of the type 2 iron-sulfur L-serine dehydratase from Legionella pneumophila
Arch. Biochem. Biophys.
596
108-117
2016
Legionella pneumophila (Q5ZXE1), Legionella pneumophila
brenda
Yan, Y.; Grant, G.A.; Gross, M.L.
Hydrogen-deuterium exchange mass spectrometry reveals unique conformational and chemical transformations occurring upon [4Fe-4S] cluster binding in the type 2 L-serine dehydratase from Legionella pneumophila
Biochemistry
54
5322-5328
2015
Legionella pneumophila (Q5ZXE1), Legionella pneumophila
brenda