Reference on EC 4.2.3.12 - 6-pyruvoyltetrahydropterin synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Thny, B.; Leimbacher, W.; Blau, N.; Heizmann, C.W.; Burgisser, D.
Human liver 6-pyruvoyl-tetrahydropterin synthase: expression of the cDNA, purification and preliminary characterization of the recombinant protein
Adv. Exp. Med. Biol.
338
187-190
1993
Homo sapiens, Rattus norvegicus
Burgisser, D.M.; Thny, B.; Redweik, U.; Hess, D.; Heizmann, C.W.; Huber, R.; Nar, H.
6-Pyruvoyl tetrahydropterin synthase, an enzyme with a novel type of active site involving both zinc binding and an intersubunit catalytic triad motif. Site-directed mutagenesis of the proposed active center, characterization of the metal binding site and modeling of substrate binding
J. Mol. Biol.
253
358-369
1995
Rattus norvegicus
Guzman, J.; Redweik, U.; Schoedon, G.; Hunziker, P.; Wiestler, O.D.; Heizmann, C.W.; Blau, N.
Purification and characterization of 6-pyruvoyl tetrahydropterin synthase from human pituitary gland
Enzyme
46
287-298
1992
Drosophila melanogaster, Homo sapiens, Salmo salar
Takikawa, S.; Curtius, H.Ch.; Redweik, U.; Ghisla, S.
Purification of 6-pyruvoyl-tetrahydropterin synthase from human liver
Biochem. Biophys. Res. Commun.
134
646-651
1986
Homo sapiens
Le van, Q.; Katzenmeier, G.; Schwarzkopf, B.; Schmid, C.; Bacher, A.
Biosynthesis of biopterin studies on the mechanism of 6-pyruvoyltetrahydropteridine synthase
Biochem. Biophys. Res. Commun.
151
512-517
1988
Bos taurus
Hauer, C.R.; Leimbacher, W.; Hunziker, P.; Neuheiser, F.; Blau, N.; Heizmann, C.W.
6-Pyruvoyl tetrahydropterin synthase from salmon liver amino acid sequence analysis by tandem mass spectrometry
Biochem. Biophys. Res. Commun.
182
953-959
1992
Salmo salar
Ashida, A.; Hatakeyama, K.; Kagamiyama, H.
cDNA cloning, expression in Escherichia coli and purification of human 6-pyruvoyl-tetrahydropterin synthase
Biochem. Biophys. Res. Commun.
195
1386-1393
1993
Homo sapiens (Q03393), Homo sapiens
Auerbach, G.; Nar, H.
The pathway from GTP to tetrahydropterin: three-dimensional structures of GTP cyclohydrolase I and 6-pyruvoyl tetrahydropterin synthase
Biol. Chem.
378
185-192
1997
Bombyx mori, Bos taurus, Drosophila melanogaster, Homo sapiens, Rattus norvegicus (P27213)
Masada, M.
Enzymatic properties of 6-pyruvoyl tetrahydropterin synthase purified from fat bodies of silkworm larvae
Adv. Exp. Med. Biol.
338
191-194
1993
Bombyx mori
Burgisser, D.M.; Thny, B.; Redweik, U.; Hunziker, P.; Heizmann, C.W.; Blau, N.
Expression and characterization of recombinant human and rat liver 6-pyruvoyl tetrahydropterin synthase. Modified cysteine residues inhibit the enzyme activity
Eur. J. Biochem.
219
497-502
1994
Homo sapiens, Rattus norvegicus
Oppliger, T.; Thny, B.; Nar, H.; Burgisser, D.; Huber, R.; Heizmann, C.W.; Blau, N.
Structural and functional consequences of mutations in 6-pyruvoyltetrahydropterin synthase causing hyperphenylalaninemia in humans
J. Biol. Chem.
270
29498-29506
1995
Homo sapiens
Inoue, Y.; Kawasaki, Y.; Harada, T.; Hatekeyama, K.; Kagamiyama, H.
Purification and cDNA cloning of rat 6-pyruvoyl-tetrahydropterin synthase
J. Biol. Chem.
266
20791-20796
1991
Rattus norvegicus (P27213)
Takikawa, S.; Curtius, H.C.; Redweik, U.; Leimbacher, W.; Ghisla, S.
Biosynthesis of tetrahydropterin. Purification and characterization of 6-pyruvoyl-tetrahydropterin synthase from human liver
Eur. J. Biochem.
161
295-302
1986
Homo sapiens
Hasler, T.; Curtius, H.C.
Purification and characterization of 6-pyruvoyl tetrahydropterin synthase from salmon liver
Eur. J. Biochem.
180
205-211
1989
Salmo salar
Park, Y.S.; Kim, J.H.; Jacobson, K.B.; Yim, J.J.
Purification and characterization of 6-pyruvoyl-tetrahydropterin synthase from Drosophila melanogaster
Biochim. Biophys. Acta
1038
186-194
1990
Drosophila melanogaster
Woo, H.J.; Hwang, Y.K.; Kim, Y.J.; Kang, J.Y.; Choi, Y.K.; Kim, C.G.; Park, Y.S.
Escherichia coli 6-pyruvoyltetrahydropterin synthase ortholog encoded by ygcM has a new catalytic activity for conversion of sepiapterin to 7,8-dihydropterin
FEBS Lett.
523
234-238
2002
Drosophila melanogaster, Escherichia coli, Homo sapiens, Synechocystis sp.
Scherer-Oppliger, T.; Leimbacher, W.; Blau, N.; Thony, B.
Serine 19 of human 6-pyruvoyltetrahydropterin synthase is phosphorylated by cGMP protein kinase II
J. Biol. Chem.
274
31341-31348
1999
Homo sapiens
Leitner, K.L.; Meyer, M.; Leimbacher, W.; Peterbauer, A.; Hofer, S.; Heufler, C.; Mueller, A.; Heller, R.; Werner, E.R.; Thoeny, B.; Werner-Felmayer, G.
Low tetrahydrobiopterin biosynthetic capacity of human monocytes is caused by exon skipping in 6-pyruvoyl tetrahydropterin synthase
Biochem. J.
373
681-688
2003
Homo sapiens (Q03393), Homo sapiens
Woo, H.J.; Kang, J.Y.; Choi, Y.K.; Park, Y.S.
Production of sepiapterin in Escherichia coli by coexpression of cyanobacterial GTP cyclohydrolase I and human 6-pyruvoyltetrahydropterin synthase
Appl. Environ. Microbiol.
68
3138-3140
2002
Escherichia coli
Bracher, A.; Eisenreich, W.; Schramek, N.; Ritz, H.; Gotze, E.; Herrmann, A.; Gutlich, M.; Bacher, A.
Biosynthesis of pteridines. NMR studies on the reaction mechanisms of GTP cyclohydrolase I, pyruvoyltetrahydropterin synthase, and sepiapterin reductase
J. Biol. Chem.
273
28132-28141
1998
Homo sapiens
Linscheid, P.; Schaffner, A.; Blau, N.; Schoedon, G.
Regulation of 6-pyruvoyltetrahydropterin synthase activity and messenger RNA abundance in human vascular endothelial cells
Circulation
98
1703-1706
1998
Homo sapiens (Q03393), Homo sapiens
Ploom, T.; Thony, B.; Yim, J.; Lee, S.; Nar, H.; Leimbacher, W.; Richardson, J.; Huber, R.; Auerbach, G.
Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase
J. Mol. Biol.
286
851-860
1999
Rattus norvegicus
Liu, T.T.; Hsiao, K.J.; Lu, S.F.; Wu, S.J.; Wu, K.F.; Chiang, S.H.; Liu, X.Q.; Chen, R.G.; Yu, W.M.
Mutation analysis of the 6-pyruvoyl-tetrahydropterin synthase gene in Chinese hyperphenylalaninemia caused by tetrahydrobiopterin synthesis deficiency
Hum. Mutat.
11
76-83
1998
Homo sapiens
Tachibana, D.; Fukumasu, H.; Shintaku, H.; Fukumasu, Y.; Yamamasu, S.; Ishiko, O.; Yamano, T.; Ogita, S.
Decreased plasma tetrahydrobiopterin in pregnant women is caused by impaired 6-pyruvoyl tetrahydropterin synthase activity
Int. J. Mol. Med.
9
49-52
2002
Homo sapiens
Elzaouk, L.; Laufs, S.; Heerklotz, D.; Leimbacher, W.; Blau, N.; Resibois, A.; Thoeny, B.
Nuclear localization of tetrahydrobiopterin biosynthetic enzymes
Biochim. Biophys. Acta
1670
56-68
2004
Chlorocebus aethiops, Homo sapiens, Mus musculus, Rattus norvegicus
Franscini, N.; Bachli, E.B.; Blau, N.; Fischler, M.; Walter, R.B.; Schaffner, A.; Schoedon, G.
Functional tetrahydrobiopterin synthesis in human platelets
Circulation
110
186-192
2004
Homo sapiens
Iwanaga, N.; Yamamasu, S.I.; Tachibana, D.; Nishio, J.; Nakai, Y.; Shintaku, H.; Ishiko, O.
Activity of synthetic enzymes of tetrahydrobiopterin in the human placenta
Int. J. Mol. Med.
13
117-120
2004
Homo sapiens
Choi, Y.K.; Kong, J.S.; Park, Y.S.
Functional role of sepiapterin reductase in the biosynthesis of tetrahydropteridines in Dictyostelium discoideum Ax2
Biochim. Biophys. Acta
1760
877-882
2006
Dictyostelium discoideum, Dictyostelium discoideum AX2
Thoeny, B.; Blau, N.
Mutations in the BH4-metabolizing genes GTP cyclohydrolase I, 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase, carbinolamine-4a-dehydratase, and dihydropteridine reductase
Hum. Mutat.
27
870-878
2006
Homo sapiens
Bagautdinov, B.; Sugahara, M.; Kunishima, N.
Purification, crystallization and preliminary crystallographic analysis of archaeal 6-pyruvoyl tetrahydrobiopterin synthase homologue PH0634 from Pyrococcus horikoshii OT3
Acta Crystallogr. Sect. F
63
15-17
2007
Pyrococcus horikoshii
Kong, J.S.; Kang, J.Y.; Kim, H.L.; Kwon, O.S.; Lee, K.H.; Park, Y.S.
6-Pyruvoyltetrahydropterin synthase orthologs of either a single or dual domain structure are responsible for tetrahydrobiopterin synthesis in bacteria
FEBS Lett.
580
4900-4904
2006
Synechococcus sp.
Dittrich, S.; Mitchell, S.L.; Blagborough, A.M.; Wang, Q.; Wang, P.; Sims, P.F.; Hyde, J.E.
An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites
Mol. Microbiol.
67
609-618
2008
Plasmodium falciparum (C6KTB6), Plasmodium falciparum
Seo, K.H.; Supanga, S.; Kim, H.L.; Park, Y.S.; Jeon, C.O.; Lee, K.H.
Purification, crystallization and preliminary crystallographic analysis of a 6-pyruvoyltetrahydropterin synthase homologue from Escherichia coli
Acta Crystallogr. Sect. F
64
105-107
2008
Escherichia coli
Spoonamore, J.E.; Roberts, S.A.; Heroux, A.; Bandarian, V.
Structure of a 6-pyruvoyltetrahydropterin synthase homolog from Streptomyces coelicolor
Acta Crystallogr. Sect. F
64
875-879
2008
Streptomyces coelicolor
Sato, K.; Sumi-Ichinose, C.; Kaji, R.; Ikemoto, K.; Nomura, T.; Nagatsu, I.; Ichinose, H.; Ito, M.; Sako, W.; Nagahiro, S.; Graybiel, A.M.; Goto, S.
Differential involvement of striosome and matrix dopamine systems in a transgenic model of dopa-responsive dystonia
Proc. Natl. Acad. Sci. USA
105
12551-12556
2008
Homo sapiens
McCarty, R.M.; Somogyi, A.; Bandarian, V.
Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase
Biochemistry
48
2301-2303
2009
Escherichia coli
Pribat, A.; Jeanguenin, L.; Lara-Nunez, A.; Ziemak, M.J.; Hyde, J.E.; de Crecy-Lagard, V.; Hanson, A.D.
6-Pyruvoyltetrahydropterin synthase paralogs replace the folate synthesis enzyme dihydroneopterin aldolase in diverse bacteria
J. Bacteriol.
191
4158-4165
2009
Clostridium botulinum, Leptospira interrogans
Wang, H.; Yang, B.; Hao, G.; Feng, Y.; Chen, H.; Feng, L.; Chen, Y.Q.; Zhao, J.; Zhang, H.; Wang, L.; Chen, W.
Biochemical characterization of the tetrahydrobiopterin synthesis pathway in the oleaginous fungus, Mortierella alpina
Microbiology
157
3059-3070
2011
Mortierella alpina (G3FNL7), Mortierella alpina
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