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Disease on EC 4.2.3.12 - 6-pyruvoyltetrahydropterin synthase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
4a-hydroxytetrahydrobiopterin dehydratase deficiency
International database of tetrahydrobiopterin deficiencies.
[Screening of tetrahydrobiopterin deficiency among hyperphenylalaninemic patients]
6,7-dihydropteridine reductase deficiency
BH4 deficiency identified in a neonatal screening program for hyperphenylalaninemia.
Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience.
International database of tetrahydrobiopterin deficiencies.
Outcome of Patients With Inherited Neurotransmitter Disorders.
Reduced nitric oxide metabolites in CSF of patients with tetrahydrobiopterin deficiency.
Screening for tetrahydrobiopterin deficiencies using dried blood spots on filter paper.
Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients.
6-pyruvoyltetrahydropterin synthase deficiency
6-Pyruvoyl-tetrahydropterin synthase deficiency with generalized dystonia and diurnal fluctuation of symptoms: a clinical and molecular study.
6-pyruvoyl-tetrahydropterin synthase deficiency with mild hyperphenylalaninemia.
6-pyruvoyltetrahydropterin synthase deficiency two-case report.
6-Pyruvoyltetrahydropterin Synthase Deficiency: Review and Report of 28 Arab Subjects.
A case of 6-pyruvoyl-tetrahydropterin synthase deficiency after screening 1,500,000 newborns in Greece.
A case of 6-pyruvoyl-tetrahydropterin synthase deficiency demonstrates a more significant correlation of L-Dopa dosage with serum prolactin levels than CSF homovanillic acid levels.
Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia.
Assessment of intellectual impairment, health-related quality of life, and behavioral phenotype in patients with neurotransmitter related disorders: Data from the iNTD registry.
BH4 deficiency identified in a neonatal screening program for hyperphenylalaninemia.
Clinical, biochemical and molecular spectrum of mild 6-pyruvoyl-tetrahydropterin synthase deficiency and a case report.
Detection of phenylketonuria by the newborn screening program in Thailand.
Diagnosis and treatment of 6-pyruvoyl-tetrahydropterin synthase deficiency.
Diagnosis of dopa-responsive dystonia and other tetrahydrobiopterin disorders by the study of biopterin metabolism in fibroblasts.
Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience.
Disorders of BH4 metabolism and the treatment of patients with 6-pyruvoyl-tetrahydropterin synthase deficiency in Taiwan.
Dominant negative allele (N47D) in a compound heterozygote for a variant of 6-pyruvoyltetrahydropterin synthase deficiency causing transient hyperphenylalaninemia.
Evaluation of neonatal BH4 loading test in neonates screened for hyperphenylalaninemia.
Genetic and pharmacological correction of aberrant dopamine synthesis using patient iPSCs with BH4 metabolism disorders.
Identification of Mutations Causing 6-Pyruvoyl- Tetrahydrobiopterin Synthase Deficiency in Polish Patients With Variant Hyperphenylalaninemia.
Identification of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency in four Italian families.
Inherited metabolic diseases in the Southern Chinese population: spectrum of diseases and estimated incidence from recurrent mutations.
International database of tetrahydrobiopterin deficiencies.
Isolated central form of tetrahydrobiopterin deficiency associated with hemizygosity on chromosome 11q and a mutant allele of PTPS.
Long-term clinical outcome of 6-pyruvoyl-tetrahydropterin synthase-deficient patients.
Long-term follow-up and adult outcome of 6-pyruvoyl-tetrahydropterin synthase deficiency.
Long-term follow-up of Chinese patients who received delayed treatment for 6-pyruvoyl-tetrahydropterin synthase deficiency.
Long-term follow-up of Taiwanese Chinese patients treated early for 6-pyruvoyl-tetrahydropterin synthase deficiency.
Long-term outcome and neuroradiological findings of 31 patients with 6-pyruvoyltetrahydropterin synthase deficiency.
Maternal tetrahydrobiopterin deficiency: The course of two pregnancies and follow-up of two children in a mother with 6-pyruvoyl-tetrahydropterin synthase deficiency.
Molecular analysis and long-term follow-up of patients with different forms of 6-pyruvoyl-tetrahydropterin synthase deficiency.
Molecular characterization of 6-pyruvoyl-tetrahydropterin synthase deficiency in Japanese patients.
Mutation analysis of the 6-pyruvoyl-tetrahydropterin synthase gene in Chinese hyperphenylalaninemia caused by tetrahydrobiopterin synthesis deficiency.
Mutations in the pterin-4alpha-carbinolamine dehydratase (PCBD) gene cause a benign form of hyperphenylalaninemia.
Neopterin and biopterin concentrations in cerebrospinal fluid in controls less than 1 year old.
Neurometabolic diseases at a national referral center: five years experience at the King Faisal Specialist Hospital and Research Centre.
Novel mutation affecting the pterin-binding site of PTS gene and review of PTS mutations in Thai patients with 6-pyruvoyltetrahydropterin synthase deficiency.
Outcome and long-term follow-up of 36 patients with tetrahydrobiopterin deficiency.
Phenotypic variability, neurological outcome and genetics background of 6-pyruvoyl-tetrahydropterin synthase deficiency.
Phenylketonuria in Hong Kong Chinese: a call for hyperphenylalaninemia newborn screening in the Special Administrative Region, China.
Progression of 6-pyruvoyl-tetrahydropterin synthase deficiency from a peripheral into a central phenotype.
Pseudoexon exclusion by antisense therapy in 6-pyruvoyl-tetrahydropterin synthase deficiency.
Response of 6-pyruvoyl-tetrahydropterin synthase deficiency to tetrahydrobiopterin.
Retrospective analysis of 19 patients with 6-Pyruvoyl Tetrahydropterin Synthase Deficiency: Prolactin levels inversely correlate with growth.
Role of protein structure in variant annotation: structural insight of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency.
Screening for tetrahydrobiopterin deficiencies using dried blood spots on filter paper.
Screening for tetrahydrobiopterin deficiency among hyperphenylalaninemia patients in Southern China.
Single-step mutation scanning of the 6-pyruvoyltetrahydropterin synthase gene in patients with hyperphenylalaninemia.
Structure, genomic localization and recombinant expression of the mouse 6-pyruvoyl-tetrahydropterin synthase gene.
Subtle brain dysfunction in treated 6-pyruvoyl-tetrahydropterin synthase deficiency: relationship to motor tasks and neurophysiological tests.
Tetrahydrobiopterin biosynthesis defects examined in cytokine-stimulated fibroblasts.
Tetrahydrobiopterin-deficient hyperphenylalaninemia in the Chinese.
The treatment and clinical follow-up outcome in Iranian patients with tetrahydrobiopterin deficiency.
Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients.
WITHDRAWN: Disorders of BH4 metabolism and the treatment of patients with 6-pyruvoyl-tetrahydropterin synthase deficiency in Taiwan.
[Detection of the prevalent mutations of 6-pyruvoyl-tetrahydropterin synthase gene by PCR-RFLP analysis in Chinese patients]
[Mutation analysis and one novel mutation detection of 6-pyruvoyl tetrahydropterin synthase gene in children with tetrahydrobiopterin deficiency]
[Screening for 6-pyruvoyl-tetrahydrobiopterin synthase (PTPS) deficiency: clinical analysis of 9 patients with PTPS deficiency]
[Study on tetrahydrobiopterin deficiency in Northern Chinese population]
[The investigation of differential diagnostic development and incidence of tetrahydrobiopterin deficiency]
Acquired Immunodeficiency Syndrome
Protein tyrosyl phosphatases in T cell activation: implication for human immunodeficiency virus transcriptional activity.
Acute Lung Injury
The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not.
Anthrax
Finding the Smoking Gun: Protein Tyrosine Phosphatases as Tools and Targets of Unicellular Microorganisms and Viruses.
aromatic-l-amino-acid decarboxylase deficiency
Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients.
Arthritis
mRNA profilin identifies low levels of phosphatases dual-specific phosphatase-7 (DUSP7) and cell division cycle-25B (CDC25B) in patients with early arthritis.
Arthritis, Rheumatoid
mRNA profilin identifies low levels of phosphatases dual-specific phosphatase-7 (DUSP7) and cell division cycle-25B (CDC25B) in patients with early arthritis.
Asthma
Protein tyrosine phosphatases regulate asthma development in a murine asthma model.
The role of protein tyrosine phosphatases in the regulation of allergic asthma: implication of TC-PTP and PTP-1B in the modulation of disease development.
Atherosclerosis
Low M(r) protein tyrosine phosphatase inhibits growth and migration of vascular smooth muscle cells induced by platelet-derived growth factor.
Autoimmune Diseases
Association of the PTPN22 R620W polymorphism with increased risk for SLE in the genetically homogeneous population of Crete.
Bidentate inhibitors of protein tyrosine phosphatases.
Covalent inhibition of protein tyrosine phosphatases.
Gene Expression Profiles of Human Phosphotyrosine Phosphatases Consequent to Th1 Polarisation and Effector Function.
Important roles of protein tyrosine phosphatase PTPN12 in tumor progression.
mRNA profilin identifies low levels of phosphatases dual-specific phosphatase-7 (DUSP7) and cell division cycle-25B (CDC25B) in patients with early arthritis.
Non-receptor tyrosine kinase signaling in autoimmunity and therapeutic implications.
Protein tyrosine phosphatase inhibition by metals and metal complexes.
Regulation of CD4+ T Cell Signaling and Immunological Synapse by Protein Tyrosine Phosphatases: Molecular Mechanisms in Autoimmunity.
Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity.
Bone Diseases
The roles of protein tyrosine phosphatases in bone-resorbing osteoclasts.
Bone Resorption
The roles of protein tyrosine phosphatases in bone-resorbing osteoclasts.
TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function.
Breast Neoplasms
Expression profile of tyrosine phosphatases in HER2 breast cancer cells and tumors.
Leukocyte common antigen-related tyrosine phosphatase receptor: increased expression and neuronal-type splicing in breast cancer cells and tissue.
Novel PROTACs for degradation of SHP2 protein.
Protein tyrosine phosphatase PTPN9 negatively regulates ErbB2 and EGFR signaling in breast cancer cells.
Protein tyrosine phosphatases and breast cancer.
Protein tyrosine phosphatases as novel targets in breast cancer therapy.
PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization.
Targeting protein-tyrosine phosphatases in breast cancer.
The protein tyrosine phosphatase DEP-1 is induced during differentiation and inhibits growth of breast cancer cells.
Carcinogenesis
A Crosstalk Between Dual-Specific Phosphatases and Dual-Specific Protein Kinases Can Be A Potential Therapeutic Target for Anti-cancer Therapy.
Expression of protein tyrosine phosphatase alpha (RPTPalpha) in human breast cancer correlates with low tumor grade, and inhibits tumor cell growth in vitro and in vivo.
Protein tyrosine phosphatases: promising targets in pancreatic ductal adenocarcinoma.
Stepping out of the shadows: Oncogenic and tumor-promoting protein tyrosine phosphatases.
Targeting PTPs with small molecule inhibitors in cancer treatment.
The role of Shp2 (PTPN11) in cancer.
Tumor-Suppression Mechanisms of Protein Tyrosine Phosphatase O and Clinical Applications.
Carcinoma
Protein tyrosine phosphatase receptor R and Z1 expression are independent prognostic indicators in oral squamous cell carcinoma.
Carcinoma, Hepatocellular
Gene expressions of protein tyrosine phosphatases in regenerating rat liver and rat ascites hepatoma cells.
Identification of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency in four Italian families.
Carcinoma, Non-Small-Cell Lung
Novel PROTACs for degradation of SHP2 protein.
Carcinoma, Squamous Cell
Protein tyrosine phosphatase receptor R and Z1 expression are independent prognostic indicators in oral squamous cell carcinoma.
Protein-tyrosine phosphatase alpha regulates Src family kinases and alters cell-substratum adhesion.
Cardiovascular Diseases
Tyrosine phosphatases in vessel wall signaling.
Choriocarcinoma
Optimized logic rules reveal interferon-?-induced modes regulated by histone deacetylases and protein tyrosine phosphatases.
Colonic Neoplasms
Tumour suppressor function of protein tyrosine phosphatase receptor-T.
Colorectal Neoplasms
Customized Array Comparative Genomic Hybridization Analysis of 25 Phosphatase-encoding Genes in Colorectal Cancer Tissues.
Mutational analysis of the tyrosine phosphatome in colorectal cancers.
Protein tyrosine phosphatome metabolic screen identifies TC-PTP as a positive regulator of cancer cell bioenergetics and mitochondrial dynamics.
PTPS Facilitates Compartmentalized LTBP1 S-Nitrosylation and Promotes Tumor Growth under Hypoxia.
The role of protein tyrosine phosphatases in colorectal cancer.
Complex Regional Pain Syndromes
Reprogramming of in situ spinal cord stimulator for covering newly developed postthoracotomy pain.
Dehydration
Biological mechanisms underlying voice changes due to dehydration.
Diabetes Mellitus, Type 1
Immunohistochemical analysis of IA-2 family of protein tyrosine phosphatases in rat gastrointestinal endocrine cells.
Multimerization of the protein-tyrosine phosphatase (PTP)-like insulin-dependent diabetes mellitus autoantigens IA-2 and IA-2beta with receptor PTPs (RPTPs). Inhibition of RPTPalpha enzymatic activity.
Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22.
Protein tyrosine phosphatases: molecular switches in metabolism and diabetes.
Diabetes Mellitus, Type 2
A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage.
Inhibitors for proteins endowed with catalytic and non-catalytic activity which recognize pTyr.
Natural products with protein tyrosine phosphatase inhibitory activity.
Protein tyrosine phosphatases (PTPs) in diabetes: causes and therapeutic opportunities.
Protein tyrosine phosphatases: molecular switches in metabolism and diabetes.
Pu-erh tea polysaccharides decrease blood sugar by inhibition of ?-glucosidase activity in vitro and in mice.
Vascular PTPs: current developments and challenges for exploitation in Type 2 diabetes-associated vascular dysfunction.
Diabetic Neuropathies
Identification of differentially expressed genes in dorsal root ganglion in early diabetic rats.
Drug-Related Side Effects and Adverse Reactions
Postmarketing safety and effectiveness of recombinant factor IX (nonacog alfa) in Japanese patients with haemophilia B.
Dyskinesias
6-pyruvoyltetrahydropterin synthase deficiency two-case report.
Paroxysmal tremor and orofacial dyskinesia secondary to a biopterin synthesis defect.
Dystonia
6-Pyruvoyl-tetrahydropterin synthase deficiency with generalized dystonia and diurnal fluctuation of symptoms: a clinical and molecular study.
Combined Dystonia With Self-Mutilation in 6-Pyruvoyl-Tetrahydropterin Synthase (PTPS) Deficiency: A Case Report.
Long-term follow-up and adult outcome of 6-pyruvoyl-tetrahydropterin synthase deficiency.
Ehlers-Danlos Syndrome
Jerks of the latissimus dorsi muscle and intercostal neuralgia after posterolateral thoracotomy.
Eosinophilia
Protein tyrosine phosphatases regulate asthma development in a murine asthma model.
Esophageal and Gastric Varices
Percutaneous transhepatic portacaval shunt for high-risk esophageal varices.
Esophageal Neoplasms
Expression of protein tyrosine phosphatases and its significance in esophageal cancer.
Genetic Diseases, Inborn
A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage.
Protein tyrosine phosphatases in health and disease.
PTPs emerge as PIPs: protein tyrosine phosphatases with lipid-phosphatase activities in human disease.
Glioma
Protein tyrosine phosphatases in glioma biology.
Glucagonoma
Profile and differential expression of protein tyrosine phosphatases in mouse pancreatic islet tumor cell lines.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
[Changes of protein tyrosine phosphorylation in erythrocyte band 3 glucose-6-phosphate dehydrogenase deficiency]
Glucosephosphate Dehydrogenase Deficiency
[Changes of protein tyrosine phosphorylation in erythrocyte band 3 glucose-6-phosphate dehydrogenase deficiency]
Glycogen Storage Disease
Inherited metabolic diseases in the Southern Chinese population: spectrum of diseases and estimated incidence from recurrent mutations.
gtp cyclohydrolase i deficiency
Diagnosis of dopa-responsive dystonia and other tetrahydrobiopterin disorders by the study of biopterin metabolism in fibroblasts.
Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience.
International database of tetrahydrobiopterin deficiencies.
Screening for tetrahydrobiopterin deficiencies using dried blood spots on filter paper.
The treatment and clinical follow-up outcome in Iranian patients with tetrahydrobiopterin deficiency.
Heart Failure
Protein tyrosine phosphatases in cardiac physiology and pathophysiology.
Hemophilia A
Clinical Evaluation of Recombinant Factor VIII Preparation (Kogenate) in Previously Treated Patients with Hemophilia A: Descriptive Meta-Analysis of Post-Marketing Study Data.
Continued benefit demonstrated with BAY 81-8973 prophylaxis in previously treated children with severe haemophilia A: Interim analysis from the LEOPOLD Kids extension study.
Design of the HEM-POWR study: a prospective, observational study of real-world treatment with damoctocog alfa pegol in patients with haemophilia A.
Efficacy and safety of pegylated full-length recombinant factor VIII with extended half-life for perioperative haemostasis in haemophilia A patients.
Efficacy of a sucrose-formulated recombinant factor VIII used for 22 surgical procedures in patients with severe haemophilia A.
Extended half-life pegylated, full-length recombinant factor VIII for prophylaxis in children with severe haemophilia A.
Incidence of inhibitors in a cohort of 838 males with hemophilia A previously treated with factor VIII concentrates.
Inhibitor development in patients receiving recombinant factor VIII (Recombinate rAHF/Bioclate): a prospective pharmacovigilance study.
Interim data on long-term efficacy, safety and tolerability of a plasma-derived factor VIII concentrate in 109 patients with severe haemophilia A.
Natural history and clinical characteristics of inhibitors in previously treated haemophilia A patients: a case series.
Novel, human cell line-derived recombinant factor VIII (human-cl rhFVIII; Nuwiq(®) ) in adults with severe haemophilia A: efficacy and safety.
Pharmacokinetics, immunogenicity, safety, and preliminary efficacy of subcutaneous turoctocog alfa pegol in previously treated patients with severe hemophilia A (alleviate 1).
Phase 3 Clinical Trial: Perioperative Use of Nonacog Gamma, a Recombinant Factor IX, in Previously Treated Patients With Moderate/Severe Hemophilia B.
Prophylaxis vs. on-demand treatment with Nuwiq(®) (Human-cl rhFVIII) in adults with severe haemophilia A.
The prevalence and risk factors of inhibitor development of FVIII in previously treated patients with hemophilia A.
Hemophilia B
Pharmacokinetics, safety and efficacy of a recombinant factor IX product, trenonacog alfa in previously treated haemophilia B patients.
Hyperalgesia
Inhibition of protein tyrosine phosphatases in spinal dorsal horn attenuated inflammatory pain by repressing Src signaling.
Hyperesthesia
Neurophysiological Characterization of Persistent Postthoracotomy Pain.
Hyperglycemia
Vascular PTPs: current developments and challenges for exploitation in Type 2 diabetes-associated vascular dysfunction.
Hyperhidrosis
A new mode of percutaneous upper thoracic phenol sympathicolysis: report of 50 cases.
Hypersensitivity
From acute to chronic pain after thoracic surgery: the significance of different components of the acute pain response.
Where to prick the apple for skin testing?
Hypotension
Impact of fentanyl on acute and chronic pain and its side effects when used with epidural analgesia after thoracic surgery in multimodal analgesia: a retrospective cohort study.
Immune System Diseases
Natural products with protein tyrosine phosphatase inhibitory activity.
Infections
Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism.
Nitropropenyl benzodioxole, an anti-infective agent with action as a protein tyrosine phosphatase inhibitor.
Protein tyrosine phosphatases in pathological process.
The prevalence and risk factors of inhibitor development of FVIII in previously treated patients with hemophilia A.
Inflammatory Bowel Diseases
Protein Tyrosine Phosphatases: Regulators of CD4 T Cells in Inflammatory Bowel Disease.
Role of protein tyrosine phosphatases in regulating the immune system: implications for chronic intestinal inflammation.
Insulin Resistance
Effects of a supranutritional dose of selenate compared with selenite on insulin sensitivity in type II diabetic dbdb mice.
Involvement of protein tyrosine phosphatases and inflammation in hypothalamic insulin resistance associated with ageing: Effect of caloric restriction.
Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance.
Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked insulin resistance.
Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action.
Vascular PTPs: current developments and challenges for exploitation in Type 2 diabetes-associated vascular dysfunction.
Insulinoma
Immunohistochemical analysis of IA-2 family of protein tyrosine phosphatases in rat gastrointestinal endocrine cells.
Profile and differential expression of protein tyrosine phosphatases in mouse pancreatic islet tumor cell lines.
Intellectual Disability
6-pyruvoyltetrahydropterin synthase deficiency two-case report.
Long-term follow-up and adult outcome of 6-pyruvoyl-tetrahydropterin synthase deficiency.
Retrovirus-mediated double transduction of the GTPCH and PTPS genes allows 6-pyruvoyltetrahydropterin synthase-deficient human fibroblasts to synthesize and release tetrahydrobiopterin.
Leishmaniasis
Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatases.
Proteases and phosphatases during Leishmania-macrophage interaction: paving the road for pathogenesis.
Leukemia
Evaluating effects of tyrosine phosphatase inhibitors on T cell receptor signaling.
Genetic alterations of protein tyrosine phosphatases in human cancers.
Novel PROTACs for degradation of SHP2 protein.
Leukemia, Myeloid, Acute
Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression.
Lung Diseases
The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not.
Lung Neoplasms
Erector spinae plane (ESP) block in the management of post thoracotomy pain syndrome: A case series.
Novel PROTACs for degradation of SHP2 protein.
The Nonreceptor-Type Tyrosine Phosphatase PTPN13 Is a Tumor Suppressor Gene in Non-Small Cell Lung Cancer.
Uniportal video-assisted thoracic surgery reduced the occurrence of post-thoracotomy pain syndrome after lobectomy for lung cancer.
Lymphoma, B-Cell
PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest.
Malaria
6-Pyruvoyltetrahydropterin Synthase Paralogs Replace the Folate Synthesis Enzyme Dihydroneopterin Aldolase in Diverse Bacteria.
An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites.
Melanoma
Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment.
Protein tyrosine phosphatases, new targets for cancer therapy.
Meningoencephalitis
Distinct and redundant roles of protein tyrosine phosphatases, Ptp1 and Ptp2, in governing the differentiation and pathogenicity of Cryptococcus neoformans.
Metabolic Diseases
The Extended Family of Protein Tyrosine Phosphatases.
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
Inherited metabolic diseases in the Southern Chinese population: spectrum of diseases and estimated incidence from recurrent mutations.
Multiple Carboxylase Deficiency
Inherited metabolic diseases in the Southern Chinese population: spectrum of diseases and estimated incidence from recurrent mutations.
Muscle Hypotonia
Long-term follow-up and adult outcome of 6-pyruvoyl-tetrahydropterin synthase deficiency.
Muscular Diseases
PTPs emerge as PIPs: protein tyrosine phosphatases with lipid-phosphatase activities in human disease.
Myocardial Ischemia
[Effects of electroacupuncture at "Neiguan" (PC 6) on sodium channel-related proteins in rats with ischemic myocardial injury].
Neoplasms
A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage.
A retrospective study of open thoracotomies versus thoracoscopic surgeries for persistent postthoracotomy pain.
Anchorage-dependent cell growth: tyrosine kinases and phosphatases meet redox regulation.
Bidentate inhibitors of protein tyrosine phosphatases.
Checks and balances: Interplay of RTKs and PTPs in cancer progression.
Covalent inhibition of protein tyrosine phosphatases.
Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.
Design, Synthesis, and In Vitro Activity of Pyrazine Compounds.
Evaluating effects of tyrosine phosphatase inhibitors on T cell receptor signaling.
Expression of protein tyrosine phosphatases and its significance in esophageal cancer.
Free-energy profiles for catalysis by dual-specificity phosphatases.
Genetic alterations of protein tyrosine phosphatases in human cancers.
High-throughput methods in identification of protein tyrosine phosphatase inhibitors and activators.
Histochemically demonstrable protein tyrosine phosphatase in human breast and colorectal cancer: large decrease in its activity in colorectal cancer suggests a tumor suppressor role in colorectal mucosal cells.
Identification of adolescents and young adults' preferences and priorities for future cancer treatment using a novel decision-making tool.
Impact of Oncogenic Protein Tyrosine Phosphatases in Cancer.
Important roles of protein tyrosine phosphatase PTPN12 in tumor progression.
Inside the human cancer tyrosine phosphatome.
Integrated analysis of proteome, phosphotyrosine-proteome, tyrosine-kinome, and tyrosine-phosphatome in acute myeloid leukemia.
Leukocyte common-antigen-related tyrosine phosphatase receptor: altered expression of mRNA and protein in the New England Deaconess Hospital rat line exhibiting spontaneous pheochromocytoma.
MAPK-specific tyrosine phosphatases: new targets for drug discovery?
Methods to monitor classical protein-tyrosine phosphatase oxidation.
Mitochondrial Permeability Transition as Target of Anticancer Drugs.
Molecular analysis of Aedes aegypti classical protein tyrosine phosphatases uncovers an ortholog of mammalian PTP-1B implicated in the control of egg production in mosquitoes.
Molecular Pathways: Targeting Protein Tyrosine Phosphatases in Cancer.
Mutational analysis of the tyrosine phosphatome in colorectal cancers.
MyPref: pilot study of a novel communication and decision-making tool for adolescents and young adults with advanced cancer.
Natural products with protein tyrosine phosphatase inhibitory activity.
Novel PROTACs for degradation of SHP2 protein.
Overexpression of PTP4A3 is associated with metastasis and unfavorable prognosis in bladder cancer.
Phosphotyrosine phosphatases in cancer diagnostic and treatment.
PRL PTPs: mediators and markers of cancer progression.
Profile and differential expression of protein tyrosine phosphatases in mouse pancreatic islet tumor cell lines.
Protein tyrosine phosphatase activity as a diagnostic parameter in breast cancer.
Protein tyrosine phosphatase inhibition by metals and metal complexes.
Protein tyrosine phosphatase receptor R and Z1 expression are independent prognostic indicators in oral squamous cell carcinoma.
Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation.
Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis.
Protein tyrosine phosphatases in cancer: friends and foes!
Protein tyrosine phosphatases in disease processes.
Protein tyrosine phosphatases in pathological process.
Protein tyrosine phosphatases, new targets for cancer therapy.
Protein tyrosine phosphatases: promising targets in pancreatic ductal adenocarcinoma.
Protein tyrosine phosphatases: prospects for therapeutics.
Protein tyrosine phosphatases: structure-function relationships.
Protein tyrosine phosphatome metabolic screen identifies TC-PTP as a positive regulator of cancer cell bioenergetics and mitochondrial dynamics.
Protein Tyrosine signaling and its potential therapeutic implications in carcinogenesis.
Protein-tyrosine phosphatases and cancer.
Protein-tyrosine phosphatases: a new frontier in platelet signal transduction.
PTEN and myotubularin: novel phosphoinositide phosphatases.
PTPN9 induces cell apoptosis by mitigating the activation of Stat3 and acts as a tumor suppressor in colorectal cancer.
PTPs emerge as PIPs: protein tyrosine phosphatases with lipid-phosphatase activities in human disease.
PTPS Facilitates Compartmentalized LTBP1 S-Nitrosylation and Promotes Tumor Growth under Hypoxia.
Recent development of small molecular specific inhibitor of protein tyrosine phosphatase 1B.
Role of Protein Tyrosine Phosphatase in Regulation of Cell Signaling Cascades Affecting Tumor Cell Growth: A Future Perspective as Anti- Cancer Drug Target.
Small molecule targeting of PTPs in cancer.
Stepping out of the shadows: Oncogenic and tumor-promoting protein tyrosine phosphatases.
Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling.
Targeting protein-tyrosine phosphatases in breast cancer.
Targeting PTPs with small molecule inhibitors in cancer treatment.
Targeting SHP-1, 2 and SHIP Pathways: A Novel Strategy for Cancer Treatment?
The Extended Family of Protein Tyrosine Phosphatases.
The impact of ultrasound-guided continuous serratus anterior plane block versus intravenous patient-controlled analgesia on the incidence and severity of post-thoracotomy pain syndrome: A randomized, controlled study.
The metal face of protein tyrosine phosphatase 1B.
The Nonreceptor-Type Tyrosine Phosphatase PTPN13 Is a Tumor Suppressor Gene in Non-Small Cell Lung Cancer.
The prevalence and risk factors of inhibitor development of FVIII in previously treated patients with hemophilia A.
The role of protein tyrosine phosphatases in colorectal cancer.
The role of Shp2 (PTPN11) in cancer.
The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers.
The tyrosine phosphatase Shp2 (PTPN11) in cancer.
Therapeutic targeting of oncogenic tyrosine phosphatases.
trans-Beta-nitrostyrene derivatives as slow-binding inhibitors of protein tyrosine phosphatases.
Transfection of human ovarian cancer cells with the HER-2/neu receptor tyrosine kinase induces a selective increase in PTP-H1, PTP-1B, PTP-alpha expression.
Tumor-Suppression Mechanisms of Protein Tyrosine Phosphatase O and Clinical Applications.
Tumour suppressor function of protein tyrosine phosphatase receptor-T.
Tyrosine phosphate in melanoma progression.
Wedelolactone, a naturally occurring coumestan, enhances interferon-? signaling through inhibiting STAT1 protein dephosphorylation.
Nervous System Diseases
Natural products with protein tyrosine phosphatase inhibitory activity.
Tyrosine phosphatase inhibition enhances neurotrophin potency and rescues nigrostriatal neurons in adult rats.
Neuralgia
A retrospective study of open thoracotomies versus thoracoscopic surgeries for persistent postthoracotomy pain.
Paravertebral Block Versus Preemptive Ketamine Effect on Pain Intensity after Posterolateral Thoracotomies: A Randomized Controlled Trial.
Post-thoracotomy pain syndrome: seldom severe, often neuropathic, treated unspecific, and insufficient.
Postthoracotomy pain syndrome.
Spinal cord stimulation for treatment of pain in a patient with post thoracotomy pain syndrome.
The Effect of Pre-Emptive Dexmedetomidine on the Incidence of Post-Thoracotomy Pain Syndrome in Patients Undergoing Coronary Artery Bypass Grafting.
Neurodegenerative Diseases
Protein Tyrosine Phosphatase as Potential Therapeutic Target in various Disorders.
Protein tyrosine phosphatases in pathological process.
Neuroinflammatory Diseases
Comparative Analysis of Protein Tyrosine Phosphatases Regulating Microglial Activation.
Protein Tyrosine Phosphatase as Potential Therapeutic Target in various Disorders.
Obesity
A microfluidics-based mobility shift assay to discover new tyrosine phosphatase inhibitors.
Covalent inhibition of protein tyrosine phosphatases.
Free-energy profiles for catalysis by dual-specificity phosphatases.
High-throughput methods in identification of protein tyrosine phosphatase inhibitors and activators.
MAPK-specific tyrosine phosphatases: new targets for drug discovery?
Molecular analysis of Aedes aegypti classical protein tyrosine phosphatases uncovers an ortholog of mammalian PTP-1B implicated in the control of egg production in mosquitoes.
Peptidyl aldehydes as reversible covalent inhibitors of protein tyrosine phosphatases.
Recent development of small molecular specific inhibitor of protein tyrosine phosphatase 1B.
Obesity, Abdominal
Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice.
Osteoporosis
Glucocorticoid-induced osteoporosis in the rat is prevented by the tyrosine phosphatase inhibitor, sodium orthovanadate.
Ovarian Neoplasms
Transfection of human ovarian cancer cells with the HER-2/neu receptor tyrosine kinase induces a selective increase in PTP-H1, PTP-1B, PTP-alpha expression.
Pancreatic Neoplasms
Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFN? signaling.
Protein tyrosine phosphatases: promising targets in pancreatic ductal adenocarcinoma.
Paralysis
Abdominal wall bulging after thoracic surgery, an underdiagnosed wound complication.
Paraplegia
Differential brain transcriptome of beta4 nAChR subunit-deficient mice: is it the effect of the null mutation or the background strain?
Paresis
Abdominal wall bulging after thoracic surgery, an underdiagnosed wound complication.
peptidyl-glutamate 4-carboxylase deficiency
Inherited metabolic diseases in the Southern Chinese population: spectrum of diseases and estimated incidence from recurrent mutations.
phenylalanine 4-monooxygenase deficiency
Phenylketonuria in Hong Kong Chinese: a call for hyperphenylalaninemia newborn screening in the Special Administrative Region, China.
Phenylketonurias
6-pyruvoyltetrahydropterin synthase deficiency two-case report.
BH4 deficiency identified in a neonatal screening program for hyperphenylalaninemia.
Chromosomal localization, genomic structure and characterization of the human gene and a retropseudogene for 6-pyruvoyltetrahydropterin synthase.
Diagnosis of dopa-responsive dystonia and other tetrahydrobiopterin disorders by the study of biopterin metabolism in fibroblasts.
Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience.
Four Years of Diagnostic Challenges with Tetrahydrobiopterin Deficiencies in Iranian Patients.
Human 6-pyruvoyltetrahydropterin synthase: cDNA cloning and heterologous expression of the recombinant enzyme.
Hyperphenylalaninemia due to defects in tetrahydrobiopterin metabolism: molecular characterization of mutations in 6-pyruvoyl-tetrahydropterin synthase.
Identification of a common 6-pyruvoyl-tetrahydropterin synthase mutation at codon 87 in Chinese phenylketonuria caused by tetrahydrobiopterin synthesis deficiency.
Inherited metabolic diseases in the Southern Chinese population: spectrum of diseases and estimated incidence from recurrent mutations.
International database of tetrahydrobiopterin deficiencies.
Isolated central form of tetrahydrobiopterin deficiency associated with hemizygosity on chromosome 11q and a mutant allele of PTPS.
Lessons from 30 years of selective screening for tetrahydrobiopterin deficiency.
Long-term follow-up of Chinese patients who received delayed treatment for 6-pyruvoyl-tetrahydropterin synthase deficiency.
Maternal tetrahydrobiopterin deficiency: The course of two pregnancies and follow-up of two children in a mother with 6-pyruvoyl-tetrahydropterin synthase deficiency.
Molecular genetics of phenylketonuria and tetrahydrobiopterin deficiency in Jordan.
Outcome and long-term follow-up of 36 patients with tetrahydrobiopterin deficiency.
Outcome of Patients With Inherited Neurotransmitter Disorders.
Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain.
Phenylketonuria in Hong Kong Chinese: a call for hyperphenylalaninemia newborn screening in the Special Administrative Region, China.
Possible high frequency of tetrahydrobiopterin deficiency in south Brazil.
Retrovirus-mediated double transduction of the GTPCH and PTPS genes allows 6-pyruvoyltetrahydropterin synthase-deficient human fibroblasts to synthesize and release tetrahydrobiopterin.
Retrovirus-mediated gene transfer of 6-pyruvoyl-tetrahydropterin synthase corrects tetrahydrobiopterin deficiency in fibroblasts from hyperphenylalaninemic patients.
Role of protein structure in variant annotation: structural insight of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency.
Screening for tetrahydrobiopterin deficiencies using dried blood spots on filter paper.
Structure, genomic localization and recombinant expression of the mouse 6-pyruvoyl-tetrahydropterin synthase gene.
Tetrahydrobiopterin deficiencies: Lesson from clinical experience.
Tetrahydrobiopterin deficiency: assay for 6-pyruvoyl-tetrahydropterin synthase activity in erythrocytes, and detection of patients and heterozygous carriers.
Tetrahydrobiopterin-deficient hyperphenylalaninemia in the Chinese.
The treatment and clinical follow-up outcome in Iranian patients with tetrahydrobiopterin deficiency.
Treatment and outcome of Taiwanese patients with 6-pyruvoyltetrahydropterin synthase gene mutations.
Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients.
[Detection of the prevalent mutations of 6-pyruvoyl-tetrahydropterin synthase gene by PCR-RFLP analysis in Chinese patients]
[Diagnosis, treatment and gene mutation analysis of the first case with dihydropteridine reductase deficiency in the mainland of China]
[Study on tetrahydrobiopterin deficiency in Northern Chinese population]
[The investigation of differential diagnostic development and incidence of tetrahydrobiopterin deficiency]
Pneumonia
Targeting protein tyrosine phosphatase to unravel possible inhibitors for Streptococcus pneumoniae using molecular docking, molecular dynamics simulations coupled with free energy calculations.
Proteinuria
Regulation of mouse podocyte process dynamics by protein tyrosine phosphatases rapid communication.
Pruritus
Impact of fentanyl on acute and chronic pain and its side effects when used with epidural analgesia after thoracic surgery in multimodal analgesia: a retrospective cohort study.
Pulmonary Fibrosis
The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not.
Seizures
6-pyruvoyltetrahydropterin synthase deficiency two-case report.
sepiapterin reductase (l-erythro-7,8-dihydrobiopterin forming) deficiency
Assessment of intellectual impairment, health-related quality of life, and behavioral phenotype in patients with neurotransmitter related disorders: Data from the iNTD registry.
Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients.
Sialorrhea
6-pyruvoyltetrahydropterin synthase deficiency two-case report.
Sleep Initiation and Maintenance Disorders
Thoracic epidural analgesia with morphine does not prevent postthoracotomy pain syndrome: a survey of 159 patients.
Squamous Cell Carcinoma of Head and Neck
Protein tyrosine phosphatase receptor R and Z1 expression are independent prognostic indicators in oral squamous cell carcinoma.
Stomach Neoplasms
Mutational analysis of the tyrosine phosphatome in colorectal cancers.
Protein tyrosine-phosphatase expression profiling in gastric cancer tissues.
succinate-semialdehyde dehydrogenase [nad(p)+] deficiency
Outcome of Patients With Inherited Neurotransmitter Disorders.
Thoracic Diseases
Uniportal video-assisted thoracic surgery reduced the occurrence of post-thoracotomy pain syndrome after lobectomy for lung cancer.
Thrombosis
Protein-tyrosine phosphatases: a new frontier in platelet signal transduction.
[Pathological anatomy of the post-thrombophlebitic syndrome]
Tremor
Paroxysmal tremor and orofacial dyskinesia secondary to a biopterin synthesis defect.
Tuberculosis
Bidentate inhibitors of protein tyrosine phosphatases.
Finding the Smoking Gun: Protein Tyrosine Phosphatases as Tools and Targets of Unicellular Microorganisms and Viruses.
Tuberculosis, Multidrug-Resistant
Multidrug-Resistant Tuberculosis in Burkina Faso from 2006 to 2017: Results of National Surveys.
Vaccinia
A selective Seoul-Fluor-based bioprobe, SfBP, for vaccinia H1-related phosphatase--a dual-specific protein tyrosine phosphatase.
Protein tyrosine phosphatase 1B inhibitory properties of seco-cucurbitane triterpenes obtained from fruiting bodies of Russula lepida.
Small molecule tools for functional interrogation of protein tyrosine phosphatases.
Varicose Veins
Blood supply routes of recurrent esophageal varices following endoscopic embolization.
Vascular Diseases
The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not.
Vascular System Injuries
Increase of PTP levels in vascular injury and in cultured aortic smooth muscle cells treated with specific growth factors.
Whooping Cough
Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons.
The phosphotyrosine phosphatase eta mediates somatostatin inhibition of glioma proliferation via the dephosphorylation of ERK1/2.