Disease on EC 4.2.3.12 - 6-pyruvoyltetrahydropterin synthase
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4a-hydroxytetrahydrobiopterin dehydratase deficiency
International database of tetrahydrobiopterin deficiencies.
4a-hydroxytetrahydrobiopterin dehydratase deficiency
[Screening of tetrahydrobiopterin deficiency among hyperphenylalaninemic patients]
6,7-dihydropteridine reductase deficiency
BH4 deficiency identified in a neonatal screening program for hyperphenylalaninemia.
6,7-dihydropteridine reductase deficiency
Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience.
6,7-dihydropteridine reductase deficiency
International database of tetrahydrobiopterin deficiencies.
6,7-dihydropteridine reductase deficiency
Outcome of Patients With Inherited Neurotransmitter Disorders.
6,7-dihydropteridine reductase deficiency
Reduced nitric oxide metabolites in CSF of patients with tetrahydrobiopterin deficiency.
6,7-dihydropteridine reductase deficiency
Screening for tetrahydrobiopterin deficiencies using dried blood spots on filter paper.
6,7-dihydropteridine reductase deficiency
Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients.
6-pyruvoyltetrahydropterin synthase deficiency
6-Pyruvoyl-tetrahydropterin synthase deficiency with generalized dystonia and diurnal fluctuation of symptoms: a clinical and molecular study.
6-pyruvoyltetrahydropterin synthase deficiency
6-pyruvoyl-tetrahydropterin synthase deficiency with mild hyperphenylalaninemia.
6-pyruvoyltetrahydropterin synthase deficiency
6-pyruvoyltetrahydropterin synthase deficiency two-case report.
6-pyruvoyltetrahydropterin synthase deficiency
6-Pyruvoyltetrahydropterin Synthase Deficiency: Review and Report of 28 Arab Subjects.
6-pyruvoyltetrahydropterin synthase deficiency
A case of 6-pyruvoyl-tetrahydropterin synthase deficiency after screening 1,500,000 newborns in Greece.
6-pyruvoyltetrahydropterin synthase deficiency
A case of 6-pyruvoyl-tetrahydropterin synthase deficiency demonstrates a more significant correlation of L-Dopa dosage with serum prolactin levels than CSF homovanillic acid levels.
6-pyruvoyltetrahydropterin synthase deficiency
Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia.
6-pyruvoyltetrahydropterin synthase deficiency
Assessment of intellectual impairment, health-related quality of life, and behavioral phenotype in patients with neurotransmitter related disorders: Data from the iNTD registry.
6-pyruvoyltetrahydropterin synthase deficiency
BH4 deficiency identified in a neonatal screening program for hyperphenylalaninemia.
6-pyruvoyltetrahydropterin synthase deficiency
Clinical, biochemical and molecular spectrum of mild 6-pyruvoyl-tetrahydropterin synthase deficiency and a case report.
6-pyruvoyltetrahydropterin synthase deficiency
Detection of phenylketonuria by the newborn screening program in Thailand.
6-pyruvoyltetrahydropterin synthase deficiency
Diagnosis and treatment of 6-pyruvoyl-tetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Diagnosis of dopa-responsive dystonia and other tetrahydrobiopterin disorders by the study of biopterin metabolism in fibroblasts.
6-pyruvoyltetrahydropterin synthase deficiency
Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience.
6-pyruvoyltetrahydropterin synthase deficiency
Disorders of BH4 metabolism and the treatment of patients with 6-pyruvoyl-tetrahydropterin synthase deficiency in Taiwan.
6-pyruvoyltetrahydropterin synthase deficiency
Dominant negative allele (N47D) in a compound heterozygote for a variant of 6-pyruvoyltetrahydropterin synthase deficiency causing transient hyperphenylalaninemia.
6-pyruvoyltetrahydropterin synthase deficiency
Evaluation of neonatal BH4 loading test in neonates screened for hyperphenylalaninemia.
6-pyruvoyltetrahydropterin synthase deficiency
Genetic and pharmacological correction of aberrant dopamine synthesis using patient iPSCs with BH4 metabolism disorders.
6-pyruvoyltetrahydropterin synthase deficiency
Identification of Mutations Causing 6-Pyruvoyl- Tetrahydrobiopterin Synthase Deficiency in Polish Patients With Variant Hyperphenylalaninemia.
6-pyruvoyltetrahydropterin synthase deficiency
Identification of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency in four Italian families.
6-pyruvoyltetrahydropterin synthase deficiency
Inherited metabolic diseases in the Southern Chinese population: spectrum of diseases and estimated incidence from recurrent mutations.
6-pyruvoyltetrahydropterin synthase deficiency
International database of tetrahydrobiopterin deficiencies.
6-pyruvoyltetrahydropterin synthase deficiency
Isolated central form of tetrahydrobiopterin deficiency associated with hemizygosity on chromosome 11q and a mutant allele of PTPS.
6-pyruvoyltetrahydropterin synthase deficiency
Long-term clinical outcome of 6-pyruvoyl-tetrahydropterin synthase-deficient patients.
6-pyruvoyltetrahydropterin synthase deficiency
Long-term follow-up and adult outcome of 6-pyruvoyl-tetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Long-term follow-up of Chinese patients who received delayed treatment for 6-pyruvoyl-tetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Long-term follow-up of Taiwanese Chinese patients treated early for 6-pyruvoyl-tetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Long-term outcome and neuroradiological findings of 31 patients with 6-pyruvoyltetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Maternal tetrahydrobiopterin deficiency: The course of two pregnancies and follow-up of two children in a mother with 6-pyruvoyl-tetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Molecular analysis and long-term follow-up of patients with different forms of 6-pyruvoyl-tetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Molecular characterization of 6-pyruvoyl-tetrahydropterin synthase deficiency in Japanese patients.
6-pyruvoyltetrahydropterin synthase deficiency
Mutation analysis of the 6-pyruvoyl-tetrahydropterin synthase gene in Chinese hyperphenylalaninemia caused by tetrahydrobiopterin synthesis deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Mutations in the pterin-4alpha-carbinolamine dehydratase (PCBD) gene cause a benign form of hyperphenylalaninemia.
6-pyruvoyltetrahydropterin synthase deficiency
Neopterin and biopterin concentrations in cerebrospinal fluid in controls less than 1 year old.
6-pyruvoyltetrahydropterin synthase deficiency
Neurometabolic diseases at a national referral center: five years experience at the King Faisal Specialist Hospital and Research Centre.
6-pyruvoyltetrahydropterin synthase deficiency
Novel mutation affecting the pterin-binding site of PTS gene and review of PTS mutations in Thai patients with 6-pyruvoyltetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Outcome and long-term follow-up of 36 patients with tetrahydrobiopterin deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Phenotypic variability, neurological outcome and genetics background of 6-pyruvoyl-tetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Phenylketonuria in Hong Kong Chinese: a call for hyperphenylalaninemia newborn screening in the Special Administrative Region, China.
6-pyruvoyltetrahydropterin synthase deficiency
Progression of 6-pyruvoyl-tetrahydropterin synthase deficiency from a peripheral into a central phenotype.
6-pyruvoyltetrahydropterin synthase deficiency
Pseudoexon exclusion by antisense therapy in 6-pyruvoyl-tetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Response of 6-pyruvoyl-tetrahydropterin synthase deficiency to tetrahydrobiopterin.
6-pyruvoyltetrahydropterin synthase deficiency
Retrospective analysis of 19 patients with 6-Pyruvoyl Tetrahydropterin Synthase Deficiency: Prolactin levels inversely correlate with growth.
6-pyruvoyltetrahydropterin synthase deficiency
Role of protein structure in variant annotation: structural insight of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Screening for tetrahydrobiopterin deficiencies using dried blood spots on filter paper.
6-pyruvoyltetrahydropterin synthase deficiency
Screening for tetrahydrobiopterin deficiency among hyperphenylalaninemia patients in Southern China.
6-pyruvoyltetrahydropterin synthase deficiency
Single-step mutation scanning of the 6-pyruvoyltetrahydropterin synthase gene in patients with hyperphenylalaninemia.
6-pyruvoyltetrahydropterin synthase deficiency
Structure, genomic localization and recombinant expression of the mouse 6-pyruvoyl-tetrahydropterin synthase gene.
6-pyruvoyltetrahydropterin synthase deficiency
Subtle brain dysfunction in treated 6-pyruvoyl-tetrahydropterin synthase deficiency: relationship to motor tasks and neurophysiological tests.
6-pyruvoyltetrahydropterin synthase deficiency
Tetrahydrobiopterin biosynthesis defects examined in cytokine-stimulated fibroblasts.
6-pyruvoyltetrahydropterin synthase deficiency
Tetrahydrobiopterin-deficient hyperphenylalaninemia in the Chinese.
6-pyruvoyltetrahydropterin synthase deficiency
The treatment and clinical follow-up outcome in Iranian patients with tetrahydrobiopterin deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients.
6-pyruvoyltetrahydropterin synthase deficiency
WITHDRAWN: Disorders of BH4 metabolism and the treatment of patients with 6-pyruvoyl-tetrahydropterin synthase deficiency in Taiwan.
6-pyruvoyltetrahydropterin synthase deficiency
[Detection of the prevalent mutations of 6-pyruvoyl-tetrahydropterin synthase gene by PCR-RFLP analysis in Chinese patients]
6-pyruvoyltetrahydropterin synthase deficiency
[Mutation analysis and one novel mutation detection of 6-pyruvoyl tetrahydropterin synthase gene in children with tetrahydrobiopterin deficiency]
6-pyruvoyltetrahydropterin synthase deficiency
[Screening for 6-pyruvoyl-tetrahydrobiopterin synthase (PTPS) deficiency: clinical analysis of 9 patients with PTPS deficiency]
6-pyruvoyltetrahydropterin synthase deficiency
[Study on tetrahydrobiopterin deficiency in Northern Chinese population]
6-pyruvoyltetrahydropterin synthase deficiency
[The investigation of differential diagnostic development and incidence of tetrahydrobiopterin deficiency]
Acquired Immunodeficiency Syndrome
Protein tyrosyl phosphatases in T cell activation: implication for human immunodeficiency virus transcriptional activity.
Acute Lung Injury
The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not.
Anthrax
Finding the Smoking Gun: Protein Tyrosine Phosphatases as Tools and Targets of Unicellular Microorganisms and Viruses.
aromatic-l-amino-acid decarboxylase deficiency
Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients.
Arthritis
mRNA profilin identifies low levels of phosphatases dual-specific phosphatase-7 (DUSP7) and cell division cycle-25B (CDC25B) in patients with early arthritis.
Arthritis, Rheumatoid
mRNA profilin identifies low levels of phosphatases dual-specific phosphatase-7 (DUSP7) and cell division cycle-25B (CDC25B) in patients with early arthritis.
Asthma
The role of protein tyrosine phosphatases in the regulation of allergic asthma: implication of TC-PTP and PTP-1B in the modulation of disease development.
Atherosclerosis
Low M(r) protein tyrosine phosphatase inhibits growth and migration of vascular smooth muscle cells induced by platelet-derived growth factor.
Autoimmune Diseases
Association of the PTPN22 R620W polymorphism with increased risk for SLE in the genetically homogeneous population of Crete.
Autoimmune Diseases
Gene Expression Profiles of Human Phosphotyrosine Phosphatases Consequent to Th1 Polarisation and Effector Function.
Autoimmune Diseases
Important roles of protein tyrosine phosphatase PTPN12 in tumor progression.
Autoimmune Diseases
mRNA profilin identifies low levels of phosphatases dual-specific phosphatase-7 (DUSP7) and cell division cycle-25B (CDC25B) in patients with early arthritis.
Autoimmune Diseases
Non-receptor tyrosine kinase signaling in autoimmunity and therapeutic implications.
Autoimmune Diseases
Regulation of CD4+ T Cell Signaling and Immunological Synapse by Protein Tyrosine Phosphatases: Molecular Mechanisms in Autoimmunity.
Autoimmune Diseases
Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity.
Bone Resorption
TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function.
Breast Neoplasms
Expression profile of tyrosine phosphatases in HER2 breast cancer cells and tumors.
Breast Neoplasms
Leukocyte common antigen-related tyrosine phosphatase receptor: increased expression and neuronal-type splicing in breast cancer cells and tissue.
Breast Neoplasms
Protein tyrosine phosphatase PTPN9 negatively regulates ErbB2 and EGFR signaling in breast cancer cells.
Breast Neoplasms
PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization.
Breast Neoplasms
The protein tyrosine phosphatase DEP-1 is induced during differentiation and inhibits growth of breast cancer cells.
Carcinogenesis
A Crosstalk Between Dual-Specific Phosphatases and Dual-Specific Protein Kinases Can Be A Potential Therapeutic Target for Anti-cancer Therapy.
Carcinogenesis
Expression of protein tyrosine phosphatase alpha (RPTPalpha) in human breast cancer correlates with low tumor grade, and inhibits tumor cell growth in vitro and in vivo.
Carcinogenesis
Protein tyrosine phosphatases: promising targets in pancreatic ductal adenocarcinoma.
Carcinogenesis
Stepping out of the shadows: Oncogenic and tumor-promoting protein tyrosine phosphatases.
Carcinogenesis
Tumor-Suppression Mechanisms of Protein Tyrosine Phosphatase O and Clinical Applications.
Carcinoma
Protein tyrosine phosphatase receptor R and Z1 expression are independent prognostic indicators in oral squamous cell carcinoma.
Carcinoma, Hepatocellular
Gene expressions of protein tyrosine phosphatases in regenerating rat liver and rat ascites hepatoma cells.
Carcinoma, Hepatocellular
Identification of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency in four Italian families.
Carcinoma, Squamous Cell
Protein tyrosine phosphatase receptor R and Z1 expression are independent prognostic indicators in oral squamous cell carcinoma.
Carcinoma, Squamous Cell
Protein-tyrosine phosphatase alpha regulates Src family kinases and alters cell-substratum adhesion.
Choriocarcinoma
Optimized logic rules reveal interferon-?-induced modes regulated by histone deacetylases and protein tyrosine phosphatases.
Colonic Neoplasms
Tumour suppressor function of protein tyrosine phosphatase receptor-T.
Colorectal Neoplasms
Customized Array Comparative Genomic Hybridization Analysis of 25 Phosphatase-encoding Genes in Colorectal Cancer Tissues.
Colorectal Neoplasms
Mutational analysis of the tyrosine phosphatome in colorectal cancers.
Colorectal Neoplasms
Protein tyrosine phosphatome metabolic screen identifies TC-PTP as a positive regulator of cancer cell bioenergetics and mitochondrial dynamics.
Colorectal Neoplasms
PTPS Facilitates Compartmentalized LTBP1 S-Nitrosylation and Promotes Tumor Growth under Hypoxia.
Complex Regional Pain Syndromes
Reprogramming of in situ spinal cord stimulator for covering newly developed postthoracotomy pain.
Diabetes Mellitus, Type 1
Immunohistochemical analysis of IA-2 family of protein tyrosine phosphatases in rat gastrointestinal endocrine cells.
Diabetes Mellitus, Type 1
Multimerization of the protein-tyrosine phosphatase (PTP)-like insulin-dependent diabetes mellitus autoantigens IA-2 and IA-2beta with receptor PTPs (RPTPs). Inhibition of RPTPalpha enzymatic activity.
Diabetes Mellitus, Type 1
Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22.
Diabetes Mellitus, Type 1
Protein tyrosine phosphatases: molecular switches in metabolism and diabetes.
Diabetes Mellitus, Type 2
A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage.
Diabetes Mellitus, Type 2
Inhibitors for proteins endowed with catalytic and non-catalytic activity which recognize pTyr.
Diabetes Mellitus, Type 2
Natural products with protein tyrosine phosphatase inhibitory activity.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatases (PTPs) in diabetes: causes and therapeutic opportunities.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatases: molecular switches in metabolism and diabetes.
Diabetes Mellitus, Type 2
Pu-erh tea polysaccharides decrease blood sugar by inhibition of ?-glucosidase activity in vitro and in mice.
Diabetes Mellitus, Type 2
Vascular PTPs: current developments and challenges for exploitation in Type 2 diabetes-associated vascular dysfunction.
Diabetic Neuropathies
Identification of differentially expressed genes in dorsal root ganglion in early diabetic rats.
Drug-Related Side Effects and Adverse Reactions
Postmarketing safety and effectiveness of recombinant factor IX (nonacog alfa) in Japanese patients with haemophilia B.
Dyskinesias
Paroxysmal tremor and orofacial dyskinesia secondary to a biopterin synthesis defect.
Dystonia
6-Pyruvoyl-tetrahydropterin synthase deficiency with generalized dystonia and diurnal fluctuation of symptoms: a clinical and molecular study.
Dystonia
Combined Dystonia With Self-Mutilation in 6-Pyruvoyl-Tetrahydropterin Synthase (PTPS) Deficiency: A Case Report.
Dystonia
Long-term follow-up and adult outcome of 6-pyruvoyl-tetrahydropterin synthase deficiency.
Ehlers-Danlos Syndrome
Jerks of the latissimus dorsi muscle and intercostal neuralgia after posterolateral thoracotomy.
Eosinophilia
Protein tyrosine phosphatases regulate asthma development in a murine asthma model.
Esophageal and Gastric Varices
Percutaneous transhepatic portacaval shunt for high-risk esophageal varices.
Esophageal Neoplasms
Expression of protein tyrosine phosphatases and its significance in esophageal cancer.
Genetic Diseases, Inborn
A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage.
Genetic Diseases, Inborn
PTPs emerge as PIPs: protein tyrosine phosphatases with lipid-phosphatase activities in human disease.
Glucagonoma
Profile and differential expression of protein tyrosine phosphatases in mouse pancreatic islet tumor cell lines.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
[Changes of protein tyrosine phosphorylation in erythrocyte band 3 glucose-6-phosphate dehydrogenase deficiency]
Glucosephosphate Dehydrogenase Deficiency
[Changes of protein tyrosine phosphorylation in erythrocyte band 3 glucose-6-phosphate dehydrogenase deficiency]
Glycogen Storage Disease
Inherited metabolic diseases in the Southern Chinese population: spectrum of diseases and estimated incidence from recurrent mutations.
gtp cyclohydrolase i deficiency
Diagnosis of dopa-responsive dystonia and other tetrahydrobiopterin disorders by the study of biopterin metabolism in fibroblasts.
gtp cyclohydrolase i deficiency
Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience.
gtp cyclohydrolase i deficiency
Screening for tetrahydrobiopterin deficiencies using dried blood spots on filter paper.
gtp cyclohydrolase i deficiency
The treatment and clinical follow-up outcome in Iranian patients with tetrahydrobiopterin deficiency.
Hemophilia A
Clinical Evaluation of Recombinant Factor VIII Preparation (Kogenate) in Previously Treated Patients with Hemophilia A: Descriptive Meta-Analysis of Post-Marketing Study Data.
Hemophilia A
Continued benefit demonstrated with BAY 81-8973 prophylaxis in previously treated children with severe haemophilia A: Interim analysis from the LEOPOLD Kids extension study.
Hemophilia A
Design of the HEM-POWR study: a prospective, observational study of real-world treatment with damoctocog alfa pegol in patients with haemophilia A.
Hemophilia A
Efficacy and safety of pegylated full-length recombinant factor VIII with extended half-life for perioperative haemostasis in haemophilia A patients.
Hemophilia A
Efficacy of a sucrose-formulated recombinant factor VIII used for 22 surgical procedures in patients with severe haemophilia A.
Hemophilia A
Extended half-life pegylated, full-length recombinant factor VIII for prophylaxis in children with severe haemophilia A.
Hemophilia A
Incidence of inhibitors in a cohort of 838 males with hemophilia A previously treated with factor VIII concentrates.
Hemophilia A
Inhibitor development in patients receiving recombinant factor VIII (Recombinate rAHF/Bioclate): a prospective pharmacovigilance study.
Hemophilia A
Interim data on long-term efficacy, safety and tolerability of a plasma-derived factor VIII concentrate in 109 patients with severe haemophilia A.
Hemophilia A
Natural history and clinical characteristics of inhibitors in previously treated haemophilia A patients: a case series.
Hemophilia A
Novel, human cell line-derived recombinant factor VIII (human-cl rhFVIII; Nuwiq(®) ) in adults with severe haemophilia A: efficacy and safety.
Hemophilia A
Pharmacokinetics, immunogenicity, safety, and preliminary efficacy of subcutaneous turoctocog alfa pegol in previously treated patients with severe hemophilia A (alleviate 1).
Hemophilia A
Phase 3 Clinical Trial: Perioperative Use of Nonacog Gamma, a Recombinant Factor IX, in Previously Treated Patients With Moderate/Severe Hemophilia B.
Hemophilia A
Prophylaxis vs. on-demand treatment with Nuwiq(®) (Human-cl rhFVIII) in adults with severe haemophilia A.
Hemophilia A
The prevalence and risk factors of inhibitor development of FVIII in previously treated patients with hemophilia A.
Hemophilia B
Pharmacokinetics, safety and efficacy of a recombinant factor IX product, trenonacog alfa in previously treated haemophilia B patients.
Hyperalgesia
Inhibition of protein tyrosine phosphatases in spinal dorsal horn attenuated inflammatory pain by repressing Src signaling.
Hyperglycemia
Vascular PTPs: current developments and challenges for exploitation in Type 2 diabetes-associated vascular dysfunction.
Hyperhidrosis
A new mode of percutaneous upper thoracic phenol sympathicolysis: report of 50 cases.
Hypersensitivity
From acute to chronic pain after thoracic surgery: the significance of different components of the acute pain response.
Hypotension
Impact of fentanyl on acute and chronic pain and its side effects when used with epidural analgesia after thoracic surgery in multimodal analgesia: a retrospective cohort study.
Immune System Diseases
Natural products with protein tyrosine phosphatase inhibitory activity.
Infections
Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism.
Infections
Nitropropenyl benzodioxole, an anti-infective agent with action as a protein tyrosine phosphatase inhibitor.
Infections
The prevalence and risk factors of inhibitor development of FVIII in previously treated patients with hemophilia A.
Inflammatory Bowel Diseases
Protein Tyrosine Phosphatases: Regulators of CD4 T Cells in Inflammatory Bowel Disease.
Inflammatory Bowel Diseases
Role of protein tyrosine phosphatases in regulating the immune system: implications for chronic intestinal inflammation.
Insulin Resistance
Effects of a supranutritional dose of selenate compared with selenite on insulin sensitivity in type II diabetic dbdb mice.
Insulin Resistance
Involvement of protein tyrosine phosphatases and inflammation in hypothalamic insulin resistance associated with ageing: Effect of caloric restriction.
Insulin Resistance
Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance.
Insulin Resistance
Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked insulin resistance.
Insulin Resistance
Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action.
Insulin Resistance
Vascular PTPs: current developments and challenges for exploitation in Type 2 diabetes-associated vascular dysfunction.
Insulinoma
Immunohistochemical analysis of IA-2 family of protein tyrosine phosphatases in rat gastrointestinal endocrine cells.
Insulinoma
Profile and differential expression of protein tyrosine phosphatases in mouse pancreatic islet tumor cell lines.
Intellectual Disability
Long-term follow-up and adult outcome of 6-pyruvoyl-tetrahydropterin synthase deficiency.
Intellectual Disability
Retrovirus-mediated double transduction of the GTPCH and PTPS genes allows 6-pyruvoyltetrahydropterin synthase-deficient human fibroblasts to synthesize and release tetrahydrobiopterin.
Leishmaniasis
Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatases.
Leishmaniasis
Proteases and phosphatases during Leishmania-macrophage interaction: paving the road for pathogenesis.
Leukemia
Evaluating effects of tyrosine phosphatase inhibitors on T cell receptor signaling.
Leukemia, Myeloid, Acute
Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression.
Lung Diseases
The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not.
Lung Neoplasms
Erector spinae plane (ESP) block in the management of post thoracotomy pain syndrome: A case series.
Lung Neoplasms
The Nonreceptor-Type Tyrosine Phosphatase PTPN13 Is a Tumor Suppressor Gene in Non-Small Cell Lung Cancer.
Lung Neoplasms
Uniportal video-assisted thoracic surgery reduced the occurrence of post-thoracotomy pain syndrome after lobectomy for lung cancer.
Lymphoma, B-Cell
PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest.
Malaria
6-Pyruvoyltetrahydropterin Synthase Paralogs Replace the Folate Synthesis Enzyme Dihydroneopterin Aldolase in Diverse Bacteria.
Malaria
An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites.
Melanoma
Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment.
Meningoencephalitis
Distinct and redundant roles of protein tyrosine phosphatases, Ptp1 and Ptp2, in governing the differentiation and pathogenicity of Cryptococcus neoformans.
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
Inherited metabolic diseases in the Southern Chinese population: spectrum of diseases and estimated incidence from recurrent mutations.
Multiple Carboxylase Deficiency
Inherited metabolic diseases in the Southern Chinese population: spectrum of diseases and estimated incidence from recurrent mutations.
Muscle Hypotonia
Long-term follow-up and adult outcome of 6-pyruvoyl-tetrahydropterin synthase deficiency.
Muscular Diseases
PTPs emerge as PIPs: protein tyrosine phosphatases with lipid-phosphatase activities in human disease.
Myocardial Ischemia
[Effects of electroacupuncture at "Neiguan" (PC 6) on sodium channel-related proteins in rats with ischemic myocardial injury].
Neoplasms
A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage.
Neoplasms
A retrospective study of open thoracotomies versus thoracoscopic surgeries for persistent postthoracotomy pain.
Neoplasms
Anchorage-dependent cell growth: tyrosine kinases and phosphatases meet redox regulation.
Neoplasms
Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.
Neoplasms
Evaluating effects of tyrosine phosphatase inhibitors on T cell receptor signaling.
Neoplasms
Expression of protein tyrosine phosphatases and its significance in esophageal cancer.
Neoplasms
High-throughput methods in identification of protein tyrosine phosphatase inhibitors and activators.
Neoplasms
Histochemically demonstrable protein tyrosine phosphatase in human breast and colorectal cancer: large decrease in its activity in colorectal cancer suggests a tumor suppressor role in colorectal mucosal cells.
Neoplasms
Identification of adolescents and young adults' preferences and priorities for future cancer treatment using a novel decision-making tool.
Neoplasms
Integrated analysis of proteome, phosphotyrosine-proteome, tyrosine-kinome, and tyrosine-phosphatome in acute myeloid leukemia.
Neoplasms
Leukocyte common-antigen-related tyrosine phosphatase receptor: altered expression of mRNA and protein in the New England Deaconess Hospital rat line exhibiting spontaneous pheochromocytoma.
Neoplasms
Molecular analysis of Aedes aegypti classical protein tyrosine phosphatases uncovers an ortholog of mammalian PTP-1B implicated in the control of egg production in mosquitoes.
Neoplasms
MyPref: pilot study of a novel communication and decision-making tool for adolescents and young adults with advanced cancer.
Neoplasms
Overexpression of PTP4A3 is associated with metastasis and unfavorable prognosis in bladder cancer.
Neoplasms
Profile and differential expression of protein tyrosine phosphatases in mouse pancreatic islet tumor cell lines.
Neoplasms
Protein tyrosine phosphatase receptor R and Z1 expression are independent prognostic indicators in oral squamous cell carcinoma.
Neoplasms
Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation.
Neoplasms
Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis.
Neoplasms
Protein tyrosine phosphatases: promising targets in pancreatic ductal adenocarcinoma.
Neoplasms
Protein tyrosine phosphatome metabolic screen identifies TC-PTP as a positive regulator of cancer cell bioenergetics and mitochondrial dynamics.
Neoplasms
Protein Tyrosine signaling and its potential therapeutic implications in carcinogenesis.
Neoplasms
PTPN9 induces cell apoptosis by mitigating the activation of Stat3 and acts as a tumor suppressor in colorectal cancer.
Neoplasms
PTPs emerge as PIPs: protein tyrosine phosphatases with lipid-phosphatase activities in human disease.
Neoplasms
PTPS Facilitates Compartmentalized LTBP1 S-Nitrosylation and Promotes Tumor Growth under Hypoxia.
Neoplasms
Recent development of small molecular specific inhibitor of protein tyrosine phosphatase 1B.
Neoplasms
Role of Protein Tyrosine Phosphatase in Regulation of Cell Signaling Cascades Affecting Tumor Cell Growth: A Future Perspective as Anti- Cancer Drug Target.
Neoplasms
Stepping out of the shadows: Oncogenic and tumor-promoting protein tyrosine phosphatases.
Neoplasms
Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling.
Neoplasms
The impact of ultrasound-guided continuous serratus anterior plane block versus intravenous patient-controlled analgesia on the incidence and severity of post-thoracotomy pain syndrome: A randomized, controlled study.
Neoplasms
The Nonreceptor-Type Tyrosine Phosphatase PTPN13 Is a Tumor Suppressor Gene in Non-Small Cell Lung Cancer.
Neoplasms
The prevalence and risk factors of inhibitor development of FVIII in previously treated patients with hemophilia A.
Neoplasms
The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers.
Neoplasms
trans-Beta-nitrostyrene derivatives as slow-binding inhibitors of protein tyrosine phosphatases.
Neoplasms
Transfection of human ovarian cancer cells with the HER-2/neu receptor tyrosine kinase induces a selective increase in PTP-H1, PTP-1B, PTP-alpha expression.
Neoplasms
Tumor-Suppression Mechanisms of Protein Tyrosine Phosphatase O and Clinical Applications.
Neoplasms
Wedelolactone, a naturally occurring coumestan, enhances interferon-? signaling through inhibiting STAT1 protein dephosphorylation.
Nervous System Diseases
Natural products with protein tyrosine phosphatase inhibitory activity.
Nervous System Diseases
Tyrosine phosphatase inhibition enhances neurotrophin potency and rescues nigrostriatal neurons in adult rats.
Neuralgia
A retrospective study of open thoracotomies versus thoracoscopic surgeries for persistent postthoracotomy pain.
Neuralgia
Paravertebral Block Versus Preemptive Ketamine Effect on Pain Intensity after Posterolateral Thoracotomies: A Randomized Controlled Trial.
Neuralgia
Post-thoracotomy pain syndrome: seldom severe, often neuropathic, treated unspecific, and insufficient.
Neuralgia
Spinal cord stimulation for treatment of pain in a patient with post thoracotomy pain syndrome.
Neuralgia
The Effect of Pre-Emptive Dexmedetomidine on the Incidence of Post-Thoracotomy Pain Syndrome in Patients Undergoing Coronary Artery Bypass Grafting.
Neurodegenerative Diseases
Protein Tyrosine Phosphatase as Potential Therapeutic Target in various Disorders.
Neuroinflammatory Diseases
Comparative Analysis of Protein Tyrosine Phosphatases Regulating Microglial Activation.
Neuroinflammatory Diseases
Protein Tyrosine Phosphatase as Potential Therapeutic Target in various Disorders.
Obesity
A microfluidics-based mobility shift assay to discover new tyrosine phosphatase inhibitors.
Obesity
High-throughput methods in identification of protein tyrosine phosphatase inhibitors and activators.
Obesity
Molecular analysis of Aedes aegypti classical protein tyrosine phosphatases uncovers an ortholog of mammalian PTP-1B implicated in the control of egg production in mosquitoes.
Obesity
Peptidyl aldehydes as reversible covalent inhibitors of protein tyrosine phosphatases.
Obesity
Recent development of small molecular specific inhibitor of protein tyrosine phosphatase 1B.
Obesity, Abdominal
Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice.
Osteoporosis
Glucocorticoid-induced osteoporosis in the rat is prevented by the tyrosine phosphatase inhibitor, sodium orthovanadate.
Ovarian Neoplasms
Transfection of human ovarian cancer cells with the HER-2/neu receptor tyrosine kinase induces a selective increase in PTP-H1, PTP-1B, PTP-alpha expression.
Pancreatic Neoplasms
Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFN? signaling.
Pancreatic Neoplasms
Protein tyrosine phosphatases: promising targets in pancreatic ductal adenocarcinoma.
Paralysis
Abdominal wall bulging after thoracic surgery, an underdiagnosed wound complication.
Paraplegia
Differential brain transcriptome of beta4 nAChR subunit-deficient mice: is it the effect of the null mutation or the background strain?
Paresis
Abdominal wall bulging after thoracic surgery, an underdiagnosed wound complication.
peptidyl-glutamate 4-carboxylase deficiency
Inherited metabolic diseases in the Southern Chinese population: spectrum of diseases and estimated incidence from recurrent mutations.
phenylalanine 4-monooxygenase deficiency
Phenylketonuria in Hong Kong Chinese: a call for hyperphenylalaninemia newborn screening in the Special Administrative Region, China.
Phenylketonurias
BH4 deficiency identified in a neonatal screening program for hyperphenylalaninemia.
Phenylketonurias
Chromosomal localization, genomic structure and characterization of the human gene and a retropseudogene for 6-pyruvoyltetrahydropterin synthase.
Phenylketonurias
Diagnosis of dopa-responsive dystonia and other tetrahydrobiopterin disorders by the study of biopterin metabolism in fibroblasts.
Phenylketonurias
Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience.
Phenylketonurias
Four Years of Diagnostic Challenges with Tetrahydrobiopterin Deficiencies in Iranian Patients.
Phenylketonurias
Human 6-pyruvoyltetrahydropterin synthase: cDNA cloning and heterologous expression of the recombinant enzyme.
Phenylketonurias
Hyperphenylalaninemia due to defects in tetrahydrobiopterin metabolism: molecular characterization of mutations in 6-pyruvoyl-tetrahydropterin synthase.
Phenylketonurias
Identification of a common 6-pyruvoyl-tetrahydropterin synthase mutation at codon 87 in Chinese phenylketonuria caused by tetrahydrobiopterin synthesis deficiency.
Phenylketonurias
Inherited metabolic diseases in the Southern Chinese population: spectrum of diseases and estimated incidence from recurrent mutations.
Phenylketonurias
Isolated central form of tetrahydrobiopterin deficiency associated with hemizygosity on chromosome 11q and a mutant allele of PTPS.
Phenylketonurias
Lessons from 30 years of selective screening for tetrahydrobiopterin deficiency.
Phenylketonurias
Long-term follow-up of Chinese patients who received delayed treatment for 6-pyruvoyl-tetrahydropterin synthase deficiency.
Phenylketonurias
Maternal tetrahydrobiopterin deficiency: The course of two pregnancies and follow-up of two children in a mother with 6-pyruvoyl-tetrahydropterin synthase deficiency.
Phenylketonurias
Molecular genetics of phenylketonuria and tetrahydrobiopterin deficiency in Jordan.
Phenylketonurias
Outcome and long-term follow-up of 36 patients with tetrahydrobiopterin deficiency.
Phenylketonurias
Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain.
Phenylketonurias
Phenylketonuria in Hong Kong Chinese: a call for hyperphenylalaninemia newborn screening in the Special Administrative Region, China.
Phenylketonurias
Retrovirus-mediated double transduction of the GTPCH and PTPS genes allows 6-pyruvoyltetrahydropterin synthase-deficient human fibroblasts to synthesize and release tetrahydrobiopterin.
Phenylketonurias
Retrovirus-mediated gene transfer of 6-pyruvoyl-tetrahydropterin synthase corrects tetrahydrobiopterin deficiency in fibroblasts from hyperphenylalaninemic patients.
Phenylketonurias
Role of protein structure in variant annotation: structural insight of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency.
Phenylketonurias
Screening for tetrahydrobiopterin deficiencies using dried blood spots on filter paper.
Phenylketonurias
Structure, genomic localization and recombinant expression of the mouse 6-pyruvoyl-tetrahydropterin synthase gene.
Phenylketonurias
Tetrahydrobiopterin deficiency: assay for 6-pyruvoyl-tetrahydropterin synthase activity in erythrocytes, and detection of patients and heterozygous carriers.
Phenylketonurias
The treatment and clinical follow-up outcome in Iranian patients with tetrahydrobiopterin deficiency.
Phenylketonurias
Treatment and outcome of Taiwanese patients with 6-pyruvoyltetrahydropterin synthase gene mutations.
Phenylketonurias
Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients.
Phenylketonurias
[Detection of the prevalent mutations of 6-pyruvoyl-tetrahydropterin synthase gene by PCR-RFLP analysis in Chinese patients]
Phenylketonurias
[Diagnosis, treatment and gene mutation analysis of the first case with dihydropteridine reductase deficiency in the mainland of China]
Phenylketonurias
[The investigation of differential diagnostic development and incidence of tetrahydrobiopterin deficiency]
Pneumonia
Targeting protein tyrosine phosphatase to unravel possible inhibitors for Streptococcus pneumoniae using molecular docking, molecular dynamics simulations coupled with free energy calculations.
Proteinuria
Regulation of mouse podocyte process dynamics by protein tyrosine phosphatases rapid communication.
Pruritus
Impact of fentanyl on acute and chronic pain and its side effects when used with epidural analgesia after thoracic surgery in multimodal analgesia: a retrospective cohort study.
Pulmonary Fibrosis
The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not.
sepiapterin reductase (l-erythro-7,8-dihydrobiopterin forming) deficiency
Assessment of intellectual impairment, health-related quality of life, and behavioral phenotype in patients with neurotransmitter related disorders: Data from the iNTD registry.
sepiapterin reductase (l-erythro-7,8-dihydrobiopterin forming) deficiency
Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients.
Sleep Initiation and Maintenance Disorders
Thoracic epidural analgesia with morphine does not prevent postthoracotomy pain syndrome: a survey of 159 patients.
Squamous Cell Carcinoma of Head and Neck
Protein tyrosine phosphatase receptor R and Z1 expression are independent prognostic indicators in oral squamous cell carcinoma.
Stomach Neoplasms
Protein tyrosine-phosphatase expression profiling in gastric cancer tissues.
succinate-semialdehyde dehydrogenase [nad(p)+] deficiency
Outcome of Patients With Inherited Neurotransmitter Disorders.
Thoracic Diseases
Uniportal video-assisted thoracic surgery reduced the occurrence of post-thoracotomy pain syndrome after lobectomy for lung cancer.
Tremor
Paroxysmal tremor and orofacial dyskinesia secondary to a biopterin synthesis defect.
Tuberculosis
Finding the Smoking Gun: Protein Tyrosine Phosphatases as Tools and Targets of Unicellular Microorganisms and Viruses.
Tuberculosis, Multidrug-Resistant
Multidrug-Resistant Tuberculosis in Burkina Faso from 2006 to 2017: Results of National Surveys.
Vaccinia
A selective Seoul-Fluor-based bioprobe, SfBP, for vaccinia H1-related phosphatase--a dual-specific protein tyrosine phosphatase.
Vaccinia
Protein tyrosine phosphatase 1B inhibitory properties of seco-cucurbitane triterpenes obtained from fruiting bodies of Russula lepida.
Vaccinia
Small molecule tools for functional interrogation of protein tyrosine phosphatases.
Varicose Veins
Blood supply routes of recurrent esophageal varices following endoscopic embolization.
Vascular Diseases
The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not.
Vascular System Injuries
Increase of PTP levels in vascular injury and in cultured aortic smooth muscle cells treated with specific growth factors.
Whooping Cough
Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons.
Whooping Cough
The phosphotyrosine phosphatase eta mediates somatostatin inhibition of glioma proliferation via the dephosphorylation of ERK1/2.
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