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D-fuconate
2-keto-3-deoxy-D-fuconate + H2O
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
additional information
?
-
D-fuconate
2-keto-3-deoxy-D-fuconate + H2O
-
30% of the activity with D-galactonate
-
?
D-fuconate
2-keto-3-deoxy-D-fuconate + H2O
-
30% of the activity with D-galactonate
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
Aspergillus niger ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
Mycobacterium butyricum
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
Mycobacterium butyricum
-
the enzyme is strictly specific for D-galactonate
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
Mycobacterium friburgensis
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
Mycobacterium jucho
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
the enzyme is strictly specific for D-galactonate
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
?
D-galactonate
?
Mycobacterium butyricum
-
the enzyme catalyzes the first reaction in the D-galactonate catabolic pathway of non-pathogenic mycobacteria
-
-
?
D-galactonate
?
Mycobacterium butyricum
-
enzyme of D-galactonate catabolism
-
-
?
D-galactonate
?
Mycobacterium friburgensis
-
enzyme of D-galactonate catabolism
-
-
?
D-galactonate
?
Mycobacterium jucho
-
enzyme of D-galactonate catabolism
-
-
?
D-galactonate
?
-
enzyme of D-galactonate catabolism
-
-
?
D-galactonate
?
-
enzyme of D-galactonate catabolism
-
-
?
D-galactonate
?
-
enzyme of D-galactonate catabolism
-
-
?
D-galactonate
?
-
-
-
-
?
D-galactonate
?
-
induced by growth on D-galactose, D-galactonate, D-fucose, and L-arabinose over the level present in glucose-grown cells
-
-
?
D-galactonate
?
-
growth on D-galactonate, L-arabinose and D-fucose increases the enzyme activity over the level of cells grown in nutrient broth
-
-
?
additional information
?
-
the enzyme only shows activity with D-galactonate. The production of 2-dehydro-3-deoxy sugar is measured with the thiobarbituric acid assay. Substrate specificity analysis, overview. No activity with L-rhamnonate, L-galactonate, D-gulonate, D-gluconate, L-gulonate, D-arabonate, D-lyxonate, L-lyxonate, D-xylonate, mucic acid, L-fuconate, L-mannonate, D-mannonate, D-riborate, L-arabonate, D-galacturonate, and D-glucuronate
-
-
?
additional information
?
-
the enzyme only shows activity with D-galactonate. The production of 2-dehydro-3-deoxy sugar is measured with the thiobarbituric acid assay. Substrate specificity analysis, overview. No activity with L-rhamnonate, L-galactonate, D-gulonate, D-gluconate, L-gulonate, D-arabonate, D-lyxonate, L-lyxonate, D-xylonate, mucic acid, L-fuconate, L-mannonate, D-mannonate, D-riborate, L-arabonate, D-galacturonate, and D-glucuronate
-
-
?
additional information
?
-
Aspergillus niger ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7
the enzyme only shows activity with D-galactonate. The production of 2-dehydro-3-deoxy sugar is measured with the thiobarbituric acid assay. Substrate specificity analysis, overview. No activity with L-rhamnonate, L-galactonate, D-gulonate, D-gluconate, L-gulonate, D-arabonate, D-lyxonate, L-lyxonate, D-xylonate, mucic acid, L-fuconate, L-mannonate, D-mannonate, D-riborate, L-arabonate, D-galacturonate, and D-glucuronate
-
-
?
additional information
?
-
Aspergillus niger ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7
the enzyme only shows activity with D-galactonate. The production of 2-dehydro-3-deoxy sugar is measured with the thiobarbituric acid assay. Substrate specificity analysis, overview. No activity with L-rhamnonate, L-galactonate, D-gulonate, D-gluconate, L-gulonate, D-arabonate, D-lyxonate, L-lyxonate, D-xylonate, mucic acid, L-fuconate, L-mannonate, D-mannonate, D-riborate, L-arabonate, D-galacturonate, and D-glucuronate
-
-
?
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D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
-
-
-
?
D-galactonate
2-dehydro-3-deoxy-D-galactonate + H2O
Aspergillus niger ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7
-
-
-
?
D-galactonate
?
Mycobacterium butyricum
-
the enzyme catalyzes the first reaction in the D-galactonate catabolic pathway of non-pathogenic mycobacteria
-
-
?
D-galactonate
?
Mycobacterium butyricum
-
enzyme of D-galactonate catabolism
-
-
?
D-galactonate
?
Mycobacterium friburgensis
-
enzyme of D-galactonate catabolism
-
-
?
D-galactonate
?
Mycobacterium jucho
-
enzyme of D-galactonate catabolism
-
-
?
D-galactonate
?
-
enzyme of D-galactonate catabolism
-
-
?
D-galactonate
?
-
enzyme of D-galactonate catabolism
-
-
?
D-galactonate
?
-
enzyme of D-galactonate catabolism
-
-
?
D-galactonate
?
-
-
-
-
?
D-galactonate
?
-
induced by growth on D-galactose, D-galactonate, D-fucose, and L-arabinose over the level present in glucose-grown cells
-
-
?
D-galactonate
?
-
growth on D-galactonate, L-arabinose and D-fucose increases the enzyme activity over the level of cells grown in nutrient broth
-
-
?
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Co2+
-
divalent cation required, in the order of decreasing effectiveness: Mg2+, Mn2+, Co2+, Ni2+
Ni2+
-
divalent cation required, in the order of decreasing effectiveness: Mg2+, Mn2+, Co2+, Ni2+
Mg2+
-
activates
Mg2+
Mycobacterium butyricum
-
highest activity at 0.3 mM MgCl2, Mg2+ or Mn2+ required
Mg2+
-
optimal concentration: 1 mM
Mg2+
-
divalent cation required, in the order of decreasing effectiveness: Mg2+, Mn2+, Co2+, Ni2+
Mn2+
Mycobacterium butyricum
-
highest activity at 0.02 mM MnCl2, Mn2+ or Mg2+ required
Mn2+
-
divalent cation required, in the order of decreasing effectiveness: Mg2+, Mn2+, Co2+, Ni2+
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Deacon, J.; Cooper, R.A.
D-Galactonate utilisation by enteric bacteria. The catabolic pathway in Escherichia coli
FEBS Lett.
77
201-205
1977
Salmonella enterica subsp. enterica serovar Typhimurium, Escherichia coli (Q6BF17), Salmonella enterica subsp. enterica serovar Typhimurium LT-12, Escherichia coli K10 (Q6BF17)
brenda
Szumilo, T.
Pathway for D-galactonate catabolism in nonpathogenic mycobacteria
J. Bacteriol.
148
368-370
1981
Mycobacterium sp., Mycobacterium butyricum, Mycobacterium friburgensis, Mycobacterium jucho, Mycobacterium sp. 607, Mycobacterium sp. 279
brenda
Szumilo, T.
Separation and some properties of D-galactonate pathway enzymes from Mycobacterium sp. 607
Acta Microbiol. Pol.
32
47-52
1983
Mycobacterium sp., Mycobacterium sp. 607
brenda
Arias, A.; Cervenansky, C.
Galactose metabolism in Rhizobium meliloti L5-30
J. Bacteriol.
167
1092-1094
1986
Sinorhizobium meliloti, Sinorhizobium meliloti UR23, Sinorhizobium meliloti L5-30
brenda
Donald, A.; Sibley, D.; Lyons, D.E.; Dahms, A.S.
D-Galactonate dehydrase. Purification and properties
J. Biol. Chem.
254
2132-2137
1979
Pseudomonas sp.
brenda
Szumilo, T.
Purification and properties of D-galactonate dehydratase from Mycobacterium butyricum
Biochim. Biophys. Acta
661
240-246
1981
Mycobacterium butyricum
brenda
Dahms, A.S.; Sibley, D.; Huisman, W.; Donald, A.
D-Galactonate dehydratase
Methods Enzymol.
90
294-298
1982
Pseudomonas sp.
brenda
Anderson, R.L.; Hauswald, C.L.
D-Galactonate/D-fuconate dehydratase
Methods Enzymol.
90
299-302
1982
Klebsiella pneumoniae, Klebsiella pneumoniae PRL-R3
brenda
De Ley, J.; Doudoroff, M.
The metabolism of D-galactose in Pseudomonas saccharophila
J. Biol. Chem.
227
745-757
1957
Pelomonas saccharophila
brenda
Palmer, D.R.J.; Wieczorek, S.J.; Hubbard, B.K.; Mrachko, G.T.; Gerlt, J.A.
Importance of mechanistic imperatives in enzyme-catalyzed beta-elimination reactions: stereochemical consequences of the dehydration reactions catalyzed by D-galactonate dehydrase from Escherichia coli and D-glucarate dehydratase from Pseudomonas putida
J. Am. Chem. Soc.
119
9850-9581
1997
Escherichia coli
-
brenda
Elshafei, A.M.; Mohawed, S.M.; Ammar, M.S.; Abdel-Fatah, O.M.
Properties of enzymes involved in D-galactonate catabolism in fungi
Antonie van Leeuwenhoek
67
211-216
1995
Aspergillus terreus
brenda
Babbitt, P.C.; Hasson, M.S.; Wedekind, J.E.; Palmer, D.R.J.; Barrett, W.C.; Reed, G.H.; Rayment, I.; Ringe, D.; Kenyon, G.L.; Gerlt, J.A.
The enolase superfamily: a general strategy for enzyme-catalyzed abstraction of the alpha-protons of carboxylic acids
Biochemistry
35
16489-16501
1996
Escherichia coli
brenda
Zhang, L.; Thiewes, H.; van Kan, J.A.
The D-galacturonic acid catabolic pathway in Botrytis cinerea
Fungal Genet. Biol.
48
990-997
2011
no activity in Botrytis cinerea
brenda
Motter, F.A.; Kuivanen, J.; Keraenen, H.; Hilditch, S.; Penttilae, M.; Richard, P.
Categorisation of sugar acid dehydratases in Aspergillus niger
Fungal Genet. Biol.
64
67-72
2014
Aspergillus niger
brenda
Motter, F.A.; Kuivanen, J.; Keraenen, H.; Hilditch, S.; Penttilae, M.; Richard, P.
Categorisation of sugar acid dehydratases in Aspergillus niger
Fungal Genet. Biol.
64
67-72
2014
Aspergillus niger (G3Y8T6), Aspergillus niger (G3YE52), Aspergillus niger ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7 (G3Y8T6), Aspergillus niger ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7 (G3YE52)
brenda