Reference on EC 4.2.1.17 - enoyl-CoA hydratase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pawar, S.; Schulz, H.
The structure of the multienzyme complex of fatty acid oxidation from Escherichia coli
J. Biol. Chem.
256
3894-3899
1981
Escherichia coli, Escherichia coli B / ATCC 11303
Yang, S.Y.; Li, J.; He, X.Y.; Cosloy, S.D.; Schulz, H.
Evidence that the fadB gene of the fadAB operon of Escherichia coli encodes 3-hydroxyacyl-coenzyme A (CoA) epimerase, DELTA3-cis-DELTA2-trans-enoyl-CoA isomerase, and enoyl-CoA hydratase in addition to 3-hydroxyacyl-CoA dehydrogenase
J. Bacteriol.
170
2543-2548
1988
Escherichia coli
Moskowitz, G.J.; Merrick, J.M.
Metabolism of poly-beta-hydroxybutyrate. II. Enzymatic synthesis of D(-)-beta-hydroxybutyryl coenzyme A by an enoyl hydrase from Rhodospirillum rubrum
Biochemistry
8
2748-2755
1969
Rhodospirillum rubrum
Fong, J.C.; Schulz, H.
Purification and properties of pig heart crotonase and the presence of short chain and long chain enoyl coenzyme A hydratases in pig and guinea pig tissues
J. Biol. Chem.
252
542-547
1977
Sus scrofa
Sumegi, B.; Srere, P.A.
Binding of the enzymes of fatty acid beta-oxidation and some related enzymes to pig heart inner mitochondrial membrane
J. Biol. Chem.
259
8748-8752
1984
Sus scrofa
He, X.Y.; Yang, S.Y.; Schulz, H.
Inhibition of enoyl-CoA hydratase by long-chain L-3-hydroxyacyl-CoA and its possible effect on fatty acid oxidation
Arch. Biochem. Biophys.
298
527-531
1992
Bos taurus
Waterson, R.M.; Castellino, F.J.; Hass, G.M.; Hill, R.L.
Purification and characterization of cortonase from Clostridium acetobutylicum
J. Biol. Chem.
247
5266-5271
1972
Clostridium acetobutylicum
Waterson, R.M.; Hill, R.L.
Enoyl coenzyme A hydratase (crotonase). Catalytic properties of crotonase and its possible regulatory role in fatty acid oxidation
J. Biol. Chem.
247
5258-5265
1972
Bos taurus
Engel, C.K.; Kiema, T.R.; Hiltunen, J.K.; Wierenga, R.K.
The crystal structure of enoyl-CoA hydratase complexed with octanoyl-CoA reveals the structural adaptations required for binding of a long chain fatty acid-CoA molecule
J. Mol. Biol.
275
847-859
1998
Rattus norvegicus (P14604)
Alipui, O.D.; Zhang, D.; Schulz, H.
Direct hydration of 3-octynoyl-CoA by crotonase: A missing link in Konrad Bloch's enzymatic studies with 3-alkynoyl thioesters
Biochem. Biophys. Res. Commun.
292
1171-1174
2002
Escherichia coli
Kiema, T.R.; Taskinen, J.P.; Pirilae, P.L.; Koivuranta, K.T.; Wierenga, R.K.; Hiltunen, J.K.
Organization of the multifunctional enzyme type 1: interaction between N- and C-terminal domains is required for the hydratase-1/isomerase activity
Biochem. J.
367
433-441
2002
Rattus norvegicus (P14604)
Kiema, T.R.; Engel, C.K.; Schmitz, W.; Filppula, S.A.; Wierenga, R.K.; Hiltunen, J.K.
Mutagenic and enzymological studies of the hydratase and isomerase activities of 2-enoyl-CoA hydratase-1
Biochemistry
38
2991-2999
1999
Rattus norvegicus
Feng, Y.; Hofstein, H.A.; Zwahlen, J.; Tonge, P.J.
Effect of mutagenesis on the stereochemistry of enoyl-CoA hydratase
Biochemistry
41
12883-12890
2002
Rattus norvegicus
Wu, W.J.; Feng, Y.; He, X.; Hofstein, H.A.; Raleigh, D.P.; Tonge, P.J.
Stereospecificity of the reaction catalyzed by enoyl-CoA hydratase
J. Am. Chem. Soc.
122
3987-3994
2000
Rattus norvegicus
-
Qin, Y.; Haapalainen, A.M.; Conry, D.; Cuebas, D.A.; Hiltunen, J.K.; Novikov, D.K.
Recombinant 2-enoyl-CoA hydratase derived from rat peroxisomal multifunctional enzyme 2: role of the hydratase reaction in bile acid synthesis
Biochem. J.
328
377-382
1997
Rattus norvegicus
-
Hiltunen, J.K.; Palosaari, P.M.; Kunau, W.H.
Epimerization of 3-hydroxyacyl-CoA esters in rat liver. Involvement of two 2-enoyl-CoA hydratases
J. Biol. Chem.
264
13536-13540
1989
Rattus norvegicus
Wu, L.; Lin, S.; Li, D.
Comparative inhibition studies of enoyl-CoA hydratase 1 and enoyl-CoA hydratase 2 in long-chain fatty acid oxidation
Org. Lett.
10
3355-3358
2008
Rattus norvegicus
Vo, M.T.; Lee, K.W.; Jung, Y.M.; Lee, Y.H.
Comparative effect of overexpressed phaJ and fabG genes supplementing (R)-3-hydroxyalkanoate monomer units on biosynthesis of mcl-polyhydroxyalkanoate in Pseudomonas putida KCTC1639
J. Biosci. Bioeng.
106
95-98
2008
Pseudomonas putida, Pseudomonas putida KCTC 1639 / ATCC 25544
Qin, Y.M.; Poutanen, M.H.; Helander, H.M.; Kvist, A.P.; Siivari, K.M.; Schmitz, W.; Conzelmann, E.; Hellman, U.; Hiltunen, J.K.
Peroxisomal multifunctional enzyme of beta-oxidation metabolizing D-3-hydroxyacyl-CoA esters in rat liver: molecular cloning, expression and characterization
Biochem. J.
321
21-28
1997
Rattus norvegicus
Stern, J.R.
Thioltranscrotylase and beta-hydroxybutyryl CoA racemase activities of crystalline crotonase
Biochim. Biophys. Acta
26
641-643
1957
Bos taurus
Hamed, R.B.; Batchelar, E.T.; Clifton, I.J.; Schofield, C.J.
Mechanisms and structures of crotonase superfamily enzymes - how nature controls enolate and oxyanion reactivity
Cell. Mol. Life Sci.
65
2507-2527
2008
Rattus norvegicus (P14604)
Engel, C.K.; Mathieu, M.; Zeelen, J.P.; Hiltunen, J.K.; Wierenga, R.K.
Crystal structure of enoyl-coenzyme A (CoA) hydratase at 2.5 angstroms resolution: a spiral fold defines the CoA-binding pocket
EMBO J.
15
5135-5145
1996
Rattus norvegicus (P14604)
Kanazawa, M.; Ohtake, A.; Abe, H.; Yamamoto, S.; Satoh, Y.; Takayanagi, M.; Niimi, H.; Mori, M.; Hashimoto, T.
Molecular cloning and sequence analysis of the cDNA for human mitochondrial short-chain enoyl-CoA hydratase
Enzyme Protein
47
9-13
1993
Homo sapiens (P30084), Homo sapiens
Minami-Ishii, N.; Taketani, S.; Osumi, T.; Hashimoto, T.
Molecular cloning and sequence analysis of the cDNA for rat mitochondrial enoyl-CoA hydratase. Structural and evolutionary relationships linked to the bifunctional enzyme of the peroxisomal beta-oxidation system
Eur. J. Biochem.
185
73-78
1989
Rattus norvegicus (P14604)
Engel, C.K.; Kiema, T.R.; Hiltunen, J.K.; Wierenga, R.K.
The crystal structure of enoyl-CoA hydratase complexed with octanoyl-CoA reveals the structural adaptations required for binding of a long chain fatty acid-CoA molecule
J. Mol. Biol.
275
847-859
1998
Rattus norvegicus
Binstock, J.F.; Schulz, H.
Fatty acid oxidation complex from Escherichia coli
Methods Enzymol.
71
403-411
1981
Escherichia coli
Hiromasa, Y.; Yan, X.; Roche, T.E.
Specific ion influences on self-association of pyruvate dehydrogenase kinase isoform 2 (PDHK2), binding of PDHK2 to the L2 lipoyl domain, and effects of the lipoyl group-binding site inhibitor, Nov3r
Biochemistry
47
2312-2324
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Kasaragod, P.; Venkatesan, R.; Kiema, T.R.; Hiltunen, J.K.; Wierenga, R.K.
The crystal structure of liganded rat peroxisomal multifunctional enzyme type 1: a flexible molecule with two interconnected active sites
J. Biol. Chem.
285
24089-24098
2010
Rattus norvegicus (P07896)
Frandi, A.; Zucca, P.; Marvasi, M.; Mastromei, G.; Sanjust, E.; Perito, B.
Bacillus subtilis fadB (ysiB) gene encodes an enoyl-CoA hydratase
Ann. Microbiol.
61
371-374
2011
Bacillus subtilis, Bacillus subtilis 168
-
Fould, B.; Garlatti, V.; Neumann, E.; Fenel, D.; Gaboriaud, C.; Arlaud, G.J.
Structural and functional characterization of the recombinant human mitochondrial trifunctional protein
Biochemistry
49
8608-8617
2010
Homo sapiens
Zhang, J.; Song, M.; Wang, J.; Sun, M.; Wang, B.; Li, R.; Huang, Y.; Hou, L.; Jin, Y.; Wang, M.; Tang, J.
Enoyl coenzyme A hydratase 1 is an important factor in the lymphatic metastasis of tumors
Biomed. Pharmacother.
65
157-162
2011
Mus musculus
Liu, X.; Feng, R.; Du, L.
The role of enoyl-CoA hydratase short chain 1 and peroxiredoxin 3 in PP2-induced apoptosis in human breast cancer MCF-7 cells
FEBS Lett.
584
3185-3192
2010
Homo sapiens
Mohrig, J.R.; Reiter, N.J.; Kirk, R.; Zawadski, M.R.; Lamarre-Vincent, N.
Effect of buffer general acid-base catalysis on the stereoselectivity of ester and thioester H/D exchange in D2O
J. Am. Chem. Soc.
133
5124-5128
2011
Homo sapiens
Arent, S.; Christensen, C.E.; Pye, V.E.; N?rgaard, A.; Henriksen, A.
The multifunctional protein in peroxisomal beta-oxidation: structure and substrate specificity of the Arabidopsis thaliana protein MFP2
J. Biol. Chem.
285
24066-24077
2010
Arabidopsis thaliana (Q9ZPI5), Arabidopsis thaliana
Teufel, R.; Mascaraque, V.; Ismail, W.; Voss, M.; Perera, J.; Eisenreich, W.; Haehnel, W.; Fuchs, G.
Bacterial phenylalanine and phenylacetate catabolic pathway revealed
Proc. Natl. Acad. Sci. USA
107
14390-14395
2010
Pseudomonas sp., Pseudomonas putida, Escherichia coli (P76082), Pseudomonas sp. Y2
Forster-Fromme, K.; Jendrossek, D.
Catabolism of citronellol and related acyclic terpenoids in pseudomonads
Appl. Microbiol. Biotechnol.
87
859-869
2010
Pseudomonas aeruginosa, Pseudomonas citronellolis
Hawkins, A.B.; Adams, M.W.; Kelly, R.M.
Conversion of 4-hydroxybutyrate to acetyl coenzyme A and its anapleurosis in the Metallosphaera sedula 3-hydroxypropionate/4-hydroxybutyrate carbon fixation pathway
Appl. Environ. Microbiol.
80
2536-2545
2014
Metallosphaera sedula, Metallosphaera sedula DSM 5348
Amari, D.T.; Marques, C.N.; Davies, D.G.
The putative enoyl-coenzyme A hydratase DspI is required for production of the Pseudomonas aeruginosa biofilm dispersion autoinducer cis-2-decenoic acid
J. Bacteriol.
195
4600-4610
2013
Pseudomonas aeruginosa (Q9I5I4), Pseudomonas aeruginosa
Abdel-Mawgoud, A.; Lepine, F.; Deziel, E.
A chiral high-performance liquid chromatography-tandem mass spectrometry method for the stereospecific analysis of enoyl-coenzyme A hydratases/isomerases
J. Chromatogr. A
1306
37-43
2013
Escherichia coli, Pseudomonas aeruginosa
Tsuchida, S.; Kawamoto, K.; Nunome, K.; Hamaue, N.; Yoshimura, T.; Aoki, T.; Kurosawa, T.
Analysis of enoyl-coenzyme A hydratase activity and its stereospecificity using high-performance liquid chromatography equipped with chiral separation column
J. Oleo Sci.
60
221-228
2011
Rattus norvegicus
Jabeen, U.; Salim, A.
Sequence analysis and structure prediction of enoyl-CoA hydratase from Avicennia marina: implication of various amino acid residues on substrate-enzyme interactions
Phytochemistry
94
36-44
2013
Avicennia marina (Q9SE41), Avicennia marina
Nagata, R.; Kawaji, S.; Mori, Y.
Use of enoyl coenzyme A hydratase of Mycobacterium avium subsp. paratuberculosis for the serological diagnosis of Johnes disease
Vet. Immunol. Immunopathol.
155
253-258
2013
Mycobacterium avium, Mycobacterium avium ATCC 19698
Lohans, C.; Wang, D.; Wang, J.; Hamed, R.; Schofield, C.
Crotonases natures exceedingly convertible catalysts
ACS Catal.
7
6587-6599
2017
Streptomyces sp. V-1, Rattus norvegicus (P07896), Rattus norvegicus (P14604)
-
Zhang, Y.; Yang, X.; Yu, H.; Ma, G.
Theoretical insight into the catalytic mechanism of enoyl-CoA hydratase
Acta Chim. Sin.
75
494-500
2017
Homo sapiens (P30084)
-
Volodina, E.; Steinbuechel, A.
(S)-3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase (FadB') from fatty acid degradation operon of Ralstonia eutropha H16
AMB Express
4
1-9
2014
Cupriavidus necator (Q0KEG0), Cupriavidus necator DSM 428 (Q0KEG0)
Al Mutairi, F.; Shamseldin, H.E.; Alfadhel, M.; Rodenburg, R.J.; Alkuraya, F.S.
A lethal neonatal phenotype of mitochondrial short-chain enoyl-CoA hydratase-1 deficiency
Clin. Genet.
91
629-633
2017
Homo sapiens (P30084), Homo sapiens
Bedoyan, J.K.; Yang, S.P.; Ferdinandusse, S.; Jack, R.M.; Miron, A.; Grahame, G.; DeBrosse, S.D.; Hoppel, C.L.; Kerr, D.S.; Wanders, R.J.A.
Lethal neonatal case and review of primary short-chain enoyl-CoA hydratase (SCEH) deficiency associated with secondary lymphocyte pyruvate dehydrogenase complex (PDC) deficiency
Mol. Genet. Metab.
120
342-349
2017
Homo sapiens (P30084)
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