Reference on EC 4.1.99.12 - 3,4-dihydroxy-2-butanone-4-phosphate synthase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Liao, D.I.; Viitanen, P.V.; Jordan, D.B.
Cloning, expression, purification and crystallization of dihydroxybutanone phosphate synthase from Magnaporthe grisea
Acta Crystallogr. Sect. D
56
1495-1497
2000
Pyricularia grisea
Steinbacher, S.; Schiffmann, S.; Bacher, A.; Fischer, M.
Metal sites in 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with the substrate ribulose 5-phosphate
Acta Crystallogr. Sect. D
60
1338-1340
2004
Methanocaldococcus jannaschii
Picollelli, M.A.; Viitanen, P.V.; Jordan, D.B.
Spectrophotometric determination of 3,4-dihydroxy-2-butanone-4-phosphate synthase activity
Anal. Biochem.
287
347-349
2000
Escherichia coli, Escherichia coli W3110 / ATCC 27325
Liao, D.I.; Zheng, Y.J.; Viitanen, P.V.; Jordan, D.B.
Structural definition of the active site and catalytic mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase
Biochemistry
41
1795-1806
2002
Pyricularia grisea
Richter, G.; Kelly, M.; Krieger, C.; Yu, Y.; Bermel, W.; Karlsson, G.; Bacher, A.; Oschkinat, H.
NMR studies on the 46-kDa dimeric protein, 3,4-dihydroxy-2-butanone 4-phosphate synthase, using 2H, 13C, and 15N-labelling
Eur. J. Biochem.
261
57-65
1999
Escherichia coli
Volk, R.; Bacher, A.
Studies on the 4-carbon precursor in the biosynthesis of riboflavin. Purification and properties of L-3,4-dihydroxy-2-butanone-4-phosphate synthase
J. Biol. Chem.
265
19479-19485
1990
Meyerozyma guilliermondii
Volk, R.; Bacher, A.
Biosynthesis of riboflavin. Studies on the mechanism of L-3,4-dihydroxy-2-butanone 4-phosphate synthase
J. Biol. Chem.
266
20610-20618
1991
Meyerozyma guilliermondii
Fischer, M.; Romisch, W.; Schiffmann, S.; Kelly, M.; Oschkinat, H.; Steinbacher, S.; Huber, R.; Eisenreich, W.; Richter, G.; Bacher, A.
Biosynthesis of riboflavin in archaea studies on the mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase of Methanococcus jannaschii
J. Biol. Chem.
277
41410-41416
2002
Methanocaldococcus jannaschii
Jin, C.; Barrientos, A.; Tzagoloff, A.
Yeast dihydroxybutanone phosphate synthase, an enzyme of the riboflavin biosynthetic pathway, has a second unrelated function in expression of mitochondrial respiration
J. Biol. Chem.
278
14698-14703
2003
Saccharomyces cerevisiae
Steinbacher, S.; Schiffmann, S.; Richter, G.; Huber, R.; Bacher, A.; Fischer, M.
Structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-phosphate: implications for the catalytic mechanism
J. Biol. Chem.
278
42256-42265
2003
Methanocaldococcus jannaschii (Q60364)
Huembelin, M.; Griesser, V.; Keller, T.; Schurter, W.; Haiker, M.; Hohmann, H.P.; Ritz, H.; Richter, G.; Bacher, A.; Van Loon, A.P.G.M.
GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone 4-phosphate synthase are rate-limiting enzymes in riboflavin synthesis of an industrial Bacillus subtilis strain used for riboflavin production
J. Indust. Microbiol. Biotechnol.
22
1-7
1999
Bacillus subtilis
-
Echt, S.; Bauer, S.; Steinbacher, S.; Huber, R.; Bacher, A.; Fischer, M.
Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans
J. Mol. Biol.
341
1085-1096
2004
Candida albicans (Q5A3V6)
Goetze, E.; Kis, K.; Eisenreich, W.; Yamauchi, N.; Kakinuma, K.; Bacher, A.
Biosynthesis of riboflavin. Stereochemistry of the 3,4-dihydroxy-2-butanone 4-phosphate synthase reaction
J. Org. Chem.
63
6456-6457
1998
Escherichia coli
-
Richter, G.; Krieger, C.; Volk, R.; Kis, K.; Ritz, H.; Gotze, E.; Bacher, A.
Biosynthesis of riboflavin: 3,4-dihydroxy-2-butanone-4-phosphate synthase
Methods Enzymol.
280
374-382
1997
Escherichia coli K-12 (P0A7J0)
Kelly, M.J.; Ball, L.J.; Krieger, C.; Yu, Y.; Fischer, M.; Schiffmann, S.; Schmieder, P.; Kuhne, R.; Bermel, W.; Bacher, A.; Richter, G.; Oschkinat, H.
The NMR structure of the 47-kDa dimeric enzyme 3,4-dihydroxy-2-butanone-4-phosphate synthase and ligand binding studies reveal the location of the active site
Proc. Natl. Acad. Sci. USA
98
13025-13030
2001
Methanocaldococcus jannaschii, Escherichia coli (P0A7J0), Escherichia coli
Liao, D.I.; Calabrese, J.C.; Wawrzak, Z.; Viitanen, P.V.; Jordan, D.B.
Crystal structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase of riboflavin biosynthesis
Structure
9
11-18
2001
Escherichia coli (P0A7J0), Escherichia coli
Le Trong, I.; Stenkamp, R.E.
Alternative models for two crystal structures of Candida albicans 3,4-dihydroxy-2-butanone 4-phosphate synthase
Acta Crystallogr. Sect. D
64
219-220
2008
Candida albicans (Q5A3V6)
Isarankura-Na-Ayudhya, P.; Isarankura-Na-Ayudhya, C.; Treeratanapaiboon, L.; Kasikun, K.; Thipkeaw, K.; Prachayasittikul, V.
Proteomic profiling of Escherichia coli in response to heavy metals stress
Eur. J. Sci. Res.
25
679-688
2009
Escherichia coli, Escherichia coli TG1
-
Singh, M.; Kumar, P.; Karthikeyan, S.
Structural basis for pH dependent monomer-dimer transition of 3,4-dihydroxy 2-butanone-4-phosphate synthase domain from Mycobacterium tuberculosis
J. Struct. Biol.
174
374-384
2011
Mycobacterium tuberculosis (A5U2B7), Mycobacterium tuberculosis
Asai, S.; Mase, K.; Yoshioka, H.
A key enzyme for flavin synthesis is required for nitric oxide and reactive oxygen species production in disease resistance
Plant J.
62
911-924
2010
Nicotiana benthamiana
Kumar, P.; Singh, M.; Gautam, R.; Karthikeyan, S.
Potential anti-bacterial drug target: structural characterization of 3,4-dihydroxy-2-butanone-4-phosphate synthase from Salmonella typhimurium LT2
Proteins
78
3292-3303
2010
Salmonella enterica subsp. enterica serovar Typhimurium (P66032)
Singh, M.; Kumar, P.; Yadav, S.; Gautam, R.; Sharma, N.; Karthikeyan, S.
The crystal structure reveals the molecular mechanism of bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II (Rv1415) from Mycobacterium tuberculosis
Acta Crystallogr. Sect. D
69
1633-1644
2013
Mycobacterium tuberculosis (A5U2B7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Ra / ATCC 25177 (A5U2B7)
Hiltunen, H.M.; Illarionov, B.; Hedtke, B.; Fischer, M.; Grimm, B.
Arabidopsis RIBA proteins: two out of three isoforms have lost their bifunctional activity in riboflavin biosynthesis
Int. J. Mol. Sci.
13
14086-14105
2012
Arabidopsis thaliana (P47924), Arabidopsis thaliana (Q6NLQ7), Arabidopsis thaliana Col-0 (P47924), Arabidopsis thaliana Col-0 (Q6NLQ7)
Li, J.; Hua, Z.; Miao, L.; Jian, T.; Wei, Y.; Shasha, Z.; Shaocheng, Z.; Zhen, G.; Hongpeng, Z.; Ailong, H.; Deqiang, W.
The crystal structure and biochemical properties of DHBPS from Streptococcus pneumoniae, a potential anti-infective target for Gram-positive bacteria
Protein Expr. Purif.
91
161-168
2013
Streptococcus pneumoniae (A0A0H2UN41), Streptococcus pneumoniae, Streptococcus pneumoniae TIGR 4 (A0A0H2UN41)
Xu, Z.; Lin, Z.; Wang, Z.; Chen, T.
Improvement of the riboflavin production by engineering the precursor biosynthesis pathways in Escherichia coli
Chin. J. Chem. Engin.
23
1834-1839
2015
Escherichia coli (P0A7J0), Escherichia coli K-12 / MG1655 (P0A7J0)
-
Islam, Z.; Kumar, A.; Singh, S.; Salmon, L.; Karthikeyan, S.
Structural basis for competitive inhibition of 3,4-dihydroxy-2-butanone-4-phosphate synthase from Vibrio cholerae
J. Biol. Chem.
290
11293-11308
2015
no activity in Homo sapiens, Vibrio cholerae serotype O1 (Q9KKP2), Vibrio cholerae serotype O1 ATCC 39315 / El Tor Inaba N16961 (Q9KKP2)
Fang, X.; Barbetti, M.J.
Differential protein accumulations in isolates of the strawberry wilt pathogen Fusarium oxysporum f. sp. fragariae differing in virulence
J. Proteomics
108
223-237
2014
Fusarium oxysporum f. sp. fragariae
Tuan, P.A.; Zhao, S.; Kim, J.K.; Kim, Y.B.; Yang, J.; Li, C.H.; Kim, S.J.; Arasu, M.V.; Al-Dhabi, N.A.; Park, S.U.
Riboflavin accumulation and molecular characterization of cDNAs encoding bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase, lumazine synthase, and riboflavin synthase in different organs of Lycium chinense plant
Molecules
19
17141-17153
2014
Lycium chinense (W0FER2), Lycium chinense
html completed
