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((3-phenylpropionyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid
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((3-phenylpropionyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
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((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
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(2E)-3-(5-methyl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazol-3-yl)prop-2-enenitrile
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(2E)-3-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)prop-2-enenitrile
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(2E)-3-[2-(1-methylethyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazol-5-yl]prop-2-enenitrile
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(2E)-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enenitrile
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(2E)-3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enoic acid
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(2Z)-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enenitrile
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(4E)-2-(1-methylethyl)-3-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-3,5-dihydro-4H-imidazol-4-one O-ethyloxime
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(4E)-2-(1-methylethyl)-3-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-3,5-dihydro-4H-imidazol-4-one oxime
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(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-(2-methylpropyl)oxime
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-ethyloxime
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(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-methyloxime
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(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-phenyloxime
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(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-tert-butyloxime
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one oxime
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(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid
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(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
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1,1,1,3,3,3-hexafluoro-2-(2-phenoxy-1,3-thiazol-5-yl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(2H-tetrazol-2-yl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(methylsulfonyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(2-[4-[4-(methylsulfonyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(2-[[4-(trifluoromethyl)phenyl]sulfonyl]-1,3-thiazol-5-yl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(4-[(5E)-2-(1-methylethyl)-5-[(phenylperoxy)imino]-4,5-dihydro-1H-imidazol-1-yl]phenyl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(4-[5-(1-hydroxyethyl)-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(4-[5-(hydroxymethyl)-2-(1-methylethyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(4-[5-(hydroxymethyl)-2-pyridin-4-yl-1H-imidazol-1-yl]phenyl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(4-[5-[hydroxy(phenoxy)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-(4-[5-[hydroxy(phenyl)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-(1-phenylpiperidin-4-yl)-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-(4-phenylpiperazin-1-yl)-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-(4-phenylpiperidin-1-yl)-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[(4-methylphenyl)sulfanyl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[1-(3-fluorophenyl)piperidin-4-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[1-(4-fluorophenyl)piperidin-4-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[4-(2-fluorophenyl)-4-(2H-tetrazol-2-yl)piperidin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-fluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-fluorophenyl)piperidin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-methoxyphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-nitrophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-fluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-methoxyphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-methylphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-nitrophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[(4-methylphenyl)sulfanyl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-([[5-(1H-tetrazol-5-yl)pentyl]oxy]methyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-[[4-(1H-tetrazol-5-yl)butoxy]methyl]-1H-imidazol-1-yl]phenyl]propan-2-ol
1,1,1,3,3,3-hexafluoro-2-[4-[4-(hydroxymethyl)-2-(1-methylethyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[5-(1-hydroxyethyl)-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[5-(hydroxymethyl)-2-(1-methylethyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[5-(hydroxymethyl)-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[5-(hydroxymethyl)-2-pyridin-2-yl-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[5-(hydroxymethyl)-2-pyridin-4-yl-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[5-[[(1-methylethyl)amino]methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
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1,1,1,3,3,3-hexafluoro-2-[4-[5-[[(2-methoxyethyl)amino]methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
1,3-bis(2-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1,3-diethyl-1-(8-hydroxyoctyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1,3-diethyl-1-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-(4-hydroxybutyl)urea
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1,3-diethyl-3-(4-hydroxybutyl)-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
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1,3-dimethyl-1-(2-methylpropyl)butyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
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1,3-dimethyl-1-(2-methylpropyl)butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-beta-alaninate
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1-(2-cyanoethyl)-3-ethyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1-(2-phenylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)-3-(2-phenylethyl)urea
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1-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)-3-phenylurea
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1-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)butan-1-one
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1-benzyl-3-methyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1-carbamoyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]piperidinium
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1-carbamoyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]pyrrolidinium
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1-cyclohexyl-3-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)urea
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1-ethyl-1-methylpropyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
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1-ethyl-1-methylpropyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-beta-alaninate
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1-ethyl-1-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3,3-dimethylurea
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1-ethyl-3,3-dimethyl-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
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1-ethyl-3,3-dimethyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1-ethyl-3-(4-hydroxybutyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)urea
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1-ethyl-3-methyl-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)urea
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1-methoxy-3-methyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1-methyl-3-phenyl-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
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1-methyl-3-phenyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
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1-phenyl-3-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
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1-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]butan-1-ol
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1-[3-(4-hydroxyphenyl)-5-(thiophen-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
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1-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-1-methyl-3-phenylurea
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1-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylurea
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1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenyl-N-(2,2,2-trifluoroethyl)piperidine-4-carboxamide
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1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidin-4-ol
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1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carbonitrile
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1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carboxamide
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1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carboxylic acid
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1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-N-(methylsulfonyl)-4-phenylpiperidine-4-carboxamide
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1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-N-methyl-4-phenylpiperidine-4-carboxamide
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1-[5-(2,4-dibromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
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1-[5-(2,4-dichlorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
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1-[5-(2,4-difluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
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1-[5-(2,4-dimethoxyphenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-l]ethanone
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1-[5-(3,4-dibromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
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1-[5-(3,4-dichlorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
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1-[5-(4-chlorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
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1-[5-(4-hydroxyphenyl)-3-(thiophen-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
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1-[5-(furan-3-yl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
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2,2,2-trifluoro-1-[4-(pyrrolidin-1-ylcarbonyl)phenyl]ethanone
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2-(4-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-4-yl)ethyl]-3-methylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
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2-(4-[5-amino-3-(1-methylethyl)isoxazol-4-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
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2-(4-[5-amino-3-[(2E)-but-2-en-1-yl]isoxazol-4-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
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2-(4-[5-[(butylamino)methyl]-2-(1-methylethyl)-1H-imidazol-1-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
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2-(4-[5-[(butylamino)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
2-ethyl-N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]hexanamide
2-methyl-1-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propan-1-ol
2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoic acid
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2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoic acid
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2-methyl-N-(3-phenyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl)propanamide
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2-methyl-N-(3-pyridin-4-yl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl)propanamide
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2-methyl-N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)propanamide
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2-methyl-N-(pyridin-4-ylmethyl)-N-[5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl]propanamide
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2-methyl-N-propyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
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2-methyl-N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
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2-methyl-N-[4-(trifluoroacetyl)phenyl]propanamide
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2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]acetamide
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2-phenoxy-N-[4-(trifluoroacetyl)phenyl]acetamide
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2-phenoxy-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]acetamide
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2-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]ethyl (1Z)-2-methyl-N-(1-methylethyl)propanimidoate
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2-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
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2-[2-(1-methylpropyl)-5-propyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]ethenone
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2-[2-[4-(3,4-difluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
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2-[2-[4-(3-aminophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
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2-[2-[4-(3-chlorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
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2-[2-[4-(4-aminophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
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2-[3-(4-hydroxyphenyl)-5-(4-methoxy-2-nitrophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
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2-[3-(4-hydroxyphenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
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2-[3-(4-hydroxyphenyl)-5-(thiophen-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[3-(4-hydroxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[4-(3,5-dimethylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
2-[4-(5-amino-3-benzylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-butylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-ethylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-furan-3-ylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-phenylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(5-amino-3-pyridin-4-ylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
-
-
2-[4-[5-amino-3-(1-methylethyl)isoxazol-4-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-[5-amino-3-(4-methoxyphenyl)isoxazol-4-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-[5-amino-3-(ethoxymethyl)isoxazol-4-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-[5-amino-3-(trifluoromethyl)isoxazol-4-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[5-(2,4-dibromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[5-(2,4-dinitrophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[5-(3,4-difluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[5-(3,5-dimethoxyphenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[5-(4-bromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[5-(4-nitrophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[5-(furan-3-yl)-3-(4-hydroxy-3,5-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[5-(furan-3-yl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
2-[5-(pyridin-2-yl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
-
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid methyl ester
3-(1-methylethyl)-1-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methyl]-1-(2-morpholin-4-ylethyl)urea
-
-
3-(1-methylethyl)-N-pyridin-4-yl-4(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-5-carboxamide
-
-
3-(1-methylethyl)-N-[(2E)-3-phenylprop-2-en-1-yl]-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazole-5-carboxamide
-
-
3-(2-methylpropyl)-1-propyl-1-[4-(trifluoroacetyl)phenyl]urea
-
-
3-(5-amino-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)propan-1-ol
-
-
3-(5-amino-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)propanoic acid
-
-
3-methyl-1-(2-phenylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]urea
-
-
3-nitrophenyl 3-[(2-methylpropyl)(phenylcarbonyl)amino]propaneperoxoyl-4-(trifluoroacetyl)benzamide
-
-
3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
3-[(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]propanoic acid
-
-
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]-N-methylbenzamide
-
-
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzamide
-
-
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
-
-
3-[2-(1-methylethyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazol-5-yl]propanoic acid
-
-
3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoic acid
-
-
3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoic acid
-
-
3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoic acid
-
-
3-[4-carbamoyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]-N-methylbenzamide
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzamide
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzonitrile
-
-
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-1-yl]benzamide
-
-
3-[[(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)carbamoyl]amino]propanoic acid
-
-
4-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)butyric acid methyl ester
4-(2-amino-1,3-thiazol-4-yl)-7-[[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]sulfanyl]-2H-chromen-2-ol
-
-
4-(3-carboxyphenyl)-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
-
4-(4-fluorophenyl)-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
-
4-(5-amino-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)phenol
-
-
4-(trifluoroacetyl)-N-[3-(trifluoromethyl)phenyl]benzamide
-
-
4-carbamoyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholin-4-ium
-
-
4-cyano-N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzamide
-
-
4-cyano-N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]benzamide
4-cyano-N-ethyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide
-
-
4-cyano-N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]benzamide
-
-
4-cyano-N-[4-(trifluoroacetyl)phenyl]benzamide
-
-
4-cyclohexyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
-
4-cyclopropyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
-
-
4-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
-
-
4-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
-
-
4-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzonitrile
-
-
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
-
-
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1 trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
-
-
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
5-methyl-N-pyridin-4-yl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-3-carboxamide
-
-
5-[(2-methylpropanoyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]pentanoic acid
-
-
5-[(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]pentanoic acid
-
-
5-[(morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-amino]-pentanoic acid methyl ester
-
30% inhibition at 0.08 mg/ml, 50% inhibition at approximately 0.16 mg/ml
5-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]pentanenitrile
5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](2-methylpropanoyl)amino]pentanoic acid
-
-
5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](morpholin-4-ylcarbonyl)amino]pentanoic acid
-
-
6-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]hexanenitrile
Acetic anhydride
-
0.01 mg MCD is incubated with the 3fold excess of acetic anhydride leading to 70% loss of activity after 30 min
CBM-301940
-
0.01 mM, 85% inhibition
diisopropylfluorophosphate
-
-
EDTA
-
1 mM, 15% inhibition
ethyl (2E)-3-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)prop-2-enoate
-
-
ethyl 2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazole-4-carboxylate
-
-
ethyl 2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazole-4-carboxylate
-
-
ethyl 2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoate
-
-
ethyl 2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate
-
-
ethyl 2-pyridin-4-yl-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazole-4-carboxylate
-
-
ethyl 2-pyridin-4-yl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazole-4-carboxylate
-
-
ethyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
ethyl 4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
ethyl 5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazole-3-carboxylate
-
-
ethyl [((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]acetate
-
-
ethyl [([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]acetate
-
-
ethyl [[(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)carbamoyl]amino]acetate
-
-
iodoacetamide
-
1 mM, 16% inhibition
methyl (2E)-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enoate
-
-
methyl (2E)-3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]prop-2-enoate
-
-
methyl (2E)-3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]prop-2-enoate
-
-
methyl 2,2-diethyl-4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
methyl 2,2-diethyl-4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]pentanoate
-
-
methyl 3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoate
-
-
methyl 3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate
-
-
methyl 3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propanoate
-
-
methyl 3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate
-
-
methyl 4-methyl-2-(2-methylpropyl)-2-[2-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]ethyl]pentanoate
-
-
methyl 4-[(2-methylpropanoyl)[5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl]amino]benzoate
-
-
methyl 4-[(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]butanoate
-
-
methyl 4-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](morpholin-4-ylcarbonyl)amino]butanoate
-
-
methyl 5-(N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)morpholine-4-carboxamido)pentanoate
-
-
methyl 5-[(2-methylpropanoyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]pentanoate
-
-
methyl 5-[(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]pentanoate
-
-
methyl 5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](2-methylpropanoyl)amino]pentanoate
-
-
methyl 5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](morpholin-4-ylcarbonyl)amino]pentanoate
-
-
methyl N-(3-phenylpropanoyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]glycinate
-
-
methyl N-(morpholin-4-ylcarbonyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-b-alaninate
-
-
methyl N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(3-phenylpropanoyl)glycinate
-
-
methyl N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(morpholin-4-ylcarbonyl)-beta-alaninate
-
-
methyl N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(morpholin-4-ylcarbonyl)glycinate
-
-
methyl [(2-methylpropanoyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]acetate
-
-
methyl [(morpholin-4-ylcarbonyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]acetate
-
-
methyl [[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](2-methylpropanoyl)amino]acetate
-
-
methyl-5-(N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl) phenyl)morpholine-4-carboxamido)pentanoate
-
i.e. CBM-301106, specific inhibitor of the enzyme
morpholin-4-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
-
-
morpholine-4-carboxylic acid (2-hydroxyethyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid (3-cyanopropyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid butyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid ethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid heptyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid hexyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid methyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid octyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid pentyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid phenethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid propyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
morpholine-4-carboxylic acid [4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
N,2-dimethyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N,N-bis(2-methylpropyl)-4-(trifluoroacetyl)benzamide
-
-
N,N-bis(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N,N-diethyl-4-(trifluoroacetyl)benzamide
-
-
N,N-diisobutyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
N,N-dipropyl-4-(trifluoroacetyl)benzamide
-
-
N-(1,3-dimethylbutyl)-4-(trifluoroacetyl)benzamide
-
-
N-(1,5-dimethylhexyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(1-methylethyl)-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-(1-methylethyl)-3-pyridin-4-yl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-5-carboxamide
-
-
N-(1-methylethyl)-4-(trifluoroacetyl)benzamide
-
-
N-(1-methylethyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(1-methylethyl)-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(1-methylethyl)-N-phenyl-4-(trifluoroacetyl)benzamide
-
-
N-(1-methylhexyl)-4-(trifluoroacetyl)benzamide
-
-
N-(1-methylhexyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(2-cyanoethyl)-N-ethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
N-(2-cyanoethyl)-N-ethyl-4-(trifluoroacetyl)benzamide
-
-
N-(2-cyanoethyl)-N-phenoxy-4-(trifluoroacetyl)benzamide
-
-
N-(2-dimethylaminoethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-(2-hydroxyethyl)-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-(2-hydroxyethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-(2-hydroxyethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-(2-methylcyclohexyl)-4-(trifluoroacetyl)benzamide
-
-
N-(2-methylcyclopropyl)-N-propyl-4-(trifluoroacetyl)benzamide
-
-
N-(2-methylpropyl)-4-(trifluoroacetyl)benzamide
-
-
N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(2-phenoxyethyl)-4-(trifluoroacetyl)benzamide
-
-
N-(2-phenylethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-(3,3-dimethylbutyl)-4-(trifluoroacetyl)benzamide
-
-
N-(3,3-dimethylbutyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(3,3-dimethylbutyl)-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(3-cyanopropyl)-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-(3-cyanopropyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-(3-phenoxypropyl)-4-(trifluoroacetyl)benzamide
-
-
N-(3-phenylpropanoyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]glycine
-
-
N-(3-tert-butoxypropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
N-(4-cyanobutyl)-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-(4-cyanobutyl)-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-(4-cyanobutyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-(4-cyanophenyl)-2-methyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)propanamide
-
-
N-(4-cyanophenyl)-3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazole-5-carboxamide
-
-
N-(4-phenoxybutyl)-4-(trifluoroacetyl)benzamide
-
-
N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)-3-phenylpropanamide
-
-
N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)acetamide
-
-
N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)hexanamide
-
-
N-(5-methyl-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-3-yl)pyridine-4-carboxamide
-
-
N-(6-methylheptyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(cyclohexylmethyl)-4-(trifluoroacetyl)benzamide
-
-
N-(cyclopropylmethyl)-6-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]pyridine-3-carboxamide
-
-
N-(furan-2-ylmethyl)-4-(trifluoroacetyl)benzamide
-
-
N-benzyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-benzyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-benzyl-N-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N-benzyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-butyl-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-butyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-butyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-butyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)acetamide
-
-
N-butyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)pyridine-4-carboxamide
-
-
N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-butyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
N-butyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-cyclohexyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
N-cyclohexyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-cyclohexyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-ethyl-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-ethyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-ethyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-ethyl-N-(2-hydroxy-2-methylpropyl)-4-(trifluoroacetyl)benzamide
-
-
N-ethyl-N-(2-methoxyethyl)-4-(trifluoroacetyl)benzamide
-
-
N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-ethyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]pyridine-4-carboxamide
-
-
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
N-ethyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-ethyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]pyridine-4-carboxamide
-
-
N-ethylmaleimide
-
1 mM, 47% inhibition
N-heptyl-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-heptyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-heptyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-hexyl-4-(trifluoroacetyl)benzamide
-
-
N-hexyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-isopropyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-methoxy-N-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N-methyl-2-phenoxy-N-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)acetamide
-
-
N-methyl-2-phenoxy-N-[4-(trifluoroacetyl)phenyl]acetamide
-
-
N-methyl-2-phenoxy-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]acetamide
-
-
N-methyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-methyl-3-phenyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-methyl-N-(1-methylethyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-methyl-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-methyl-N-(2-phenoxyethyl)-4-(trifluoroacetyl)benzamide
-
-
N-methyl-N-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)pyridine-4-carboxamide
-
-
N-methyl-N-phenethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
-
-
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]nicotinamide
-
-
N-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]pyridine-3-carboxamide
-
-
N-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]pyridine-4-carboxamide
-
-
N-octyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-pentyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-phenethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl) benzamide
-
-
N-propyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
N-propyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]morpholine-4-carboxamide
-
-
N-[(2-hydroxyphenoxy)methyl]-4-(trifluoroacetyl)benzamide
-
-
N-[2-(dimethylamino)ethyl]-2-methyl-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]propanamide
-
-
N-[2-(dimethylamino)ethyl]-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-[3,5-bis(trifluoromethyl)phenyl]-4-(trifluoroacetyl)benzamide
-
-
N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]-2-phenylbutanamide
-
-
N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]pentanamide
-
-
N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]pyridine-4-carboxamide
-
-
N-[3-[bis(1-methylethyl)amino]-3-oxopropyl]-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methyl-N-propylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methyl-N-[4-(1H-tetrazol-5-yl)butyl]propanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-methylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-phenoxyacetamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenyl-N-(propan-2-yl)propanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-3-phenylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N,2-dimethylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2-hydroxyethyl)-2-methylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2-hydroxyethyl)morpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2-phenylethyl)morpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(3-phenylpropanoyl)glycine
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(morpholin-4-ylcarbonyl)-beta-alanine
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-hexylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methyl-2-phenoxyacetamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methyl-3-phenylpropanamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methylpyridine-3-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methylpyridine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-octylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-pentylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-propylmorpholine-4-carboxamide
-
-
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]morpholine-4-carboxamide
-
-
N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-[4-(trifluoroacetyl)phenyl]morpholine-4-carboxamide
-
-
piperidin-1-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
-
-
pyridoxal 5'-phosphate
-
partly competitive
pyrrolidin-1-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
-
-
tert-butyl (3R)-3-[(((5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl (3R)-3-[(((5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl (3R)-3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl (3R)-3-[([(5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl (3R)-3-[([(5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl (3R)-5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
-
-
tert-butyl (3S)-3-[(((5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl (3S)-3-[(((5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl (3S)-3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl (3S)-3-[([(5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl (3S)-3-[([(5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
tert-butyl (3S)-5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
-
-
tert-butyl 3-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamido)butanoate
-
i.e. CBM-301940
tert-butyl 3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
-
tert-butyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
-
-
tert-butyl 5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
tert-butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-b-alaninate
-
-
tert-butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)leucinate
-
-
tert-butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)phenylalaninate
-
-
[(2-methylpropanoyl)[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]acetic acid
-
-
[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl](2-methylpropanoyl)amino]acetic acid
-
-
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-(2-methylpropyl)oxime
-
-
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-(2-methylpropyl)oxime
-
-
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-tert-butyloxime
-
-
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-tert-butyloxime
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-([[5-(1H-tetrazol-5-yl)pentyl]oxy]methyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-([[5-(1H-tetrazol-5-yl)pentyl]oxy]methyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-[[4-(1H-tetrazol-5-yl)butoxy]methyl]-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-[[4-(1H-tetrazol-5-yl)butoxy]methyl]-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[5-[[(2-methoxyethyl)amino]methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
1,1,1,3,3,3-hexafluoro-2-[4-[5-[[(2-methoxyethyl)amino]methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
-
-
2-(4-[5-[(butylamino)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-(4-[5-[(butylamino)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-ethyl-N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]hexanamide
-
-
2-ethyl-N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]hexanamide
-
-
2-methyl-1-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propan-1-ol
-
-
2-methyl-1-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propan-1-ol
-
-
2-[4-(3,5-dimethylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
2-[4-(3,5-dimethylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
-
-
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid
-
-
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid
-
-
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid methyl ester
-
-
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid methyl ester
-
-
3-Bromopyruvate
-
weak
4-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)butyric acid methyl ester
-
-
4-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)butyric acid methyl ester
-
-
4-cyano-N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]benzamide
-
-
4-cyano-N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]benzamide
-
-
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
-
-
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
-
-
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
-
-
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
-
-
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
-
-
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
-
-
5-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]pentanenitrile
-
-
5-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]pentanenitrile
-
-
6-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]hexanenitrile
-
-
6-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]hexanenitrile
-
-
acetyl-CoA
-
-
Avidin
-
0.6 mg/ml, 11% inhibition
-
CoA
-
-
ethyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
-
-
ethyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
-
-
ethyl 4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
ethyl 4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
-
methylmalonyl-CoA
-
-
methylmalonyl-CoA
-
competitive
morpholine-4-carboxylic acid (2-hydroxyethyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid (2-hydroxyethyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid (3-cyanopropyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid (3-cyanopropyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid butyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid butyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid ethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid ethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid heptyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid heptyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid hexyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid hexyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid methyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid methyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid pentyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid pentyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid phenethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid phenethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid propyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
morpholine-4-carboxylic acid propyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
-
-
N,N-diisobutyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N,N-diisobutyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N-(2-cyanoethyl)-N-ethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N-(2-cyanoethyl)-N-ethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
-
-
N-(3-tert-butoxypropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-(3-tert-butoxypropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
-
N-butyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-butyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-cyclohexyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-cyclohexyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
-
-
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
-
-
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
-
-
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-propyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-propyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
-
-
NEM
-
enzyme with malonyl-CoA:acetate CoA transferase activity, acetylCoA:malonate CoA transferase and malonyl-CoA decarboxylase activity completely loses its malonate decarboxylase activity by treatment with NEM
NEM
-
inhibits iodoacetamide-induced malonyl-CoA decarboxylase activity
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
0.1 mM, 95.5% inhibition
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
insensitive
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
insensitive
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
insensitive
palmitoyl-CoA
-
noncompetitive
propionyl-CoA
-
-
propionyl-CoA
-
insensitive
succinyl-CoA
-
-
tert-butyl 5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
-
-
tert-butyl 5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
-
-
additional information
-
troglitazone, a specific peroxisome proliferator-activated receptor-gamma agonist, decreases MCD expression, no effect on MCD activity
-
additional information
-
cerulenin has no effect in the iodoacetamide-treated enzyme
-
additional information
-
high ionic strength inhibits
-
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0.000376
((3-phenylpropionyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000105
((3-phenylpropionyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00008
((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00029
(2E)-3-(5-methyl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazol-3-yl)prop-2-enenitrile
Rattus norvegicus
-
-
0.00014
(2E)-3-[2-(1-methylethyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazol-5-yl]prop-2-enenitrile
Rattus norvegicus
-
-
0.000118
(4E)-2-(1-methylethyl)-3-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-3,5-dihydro-4H-imidazol-4-one O-ethyloxime
Rattus norvegicus
-
-
0.000152
(4E)-2-(1-methylethyl)-3-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-3,5-dihydro-4H-imidazol-4-one oxime
Rattus norvegicus
-
-
0.00035
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-(2-methylpropyl)oxime
Rattus norvegicus
-
-
0.000044
(4E)-2-(1-methylethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3,5-dihydro-4H-imidazol-4-one O-tert-butyloxime
Rattus norvegicus
-
-
0.000627
(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000034
(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)acetic acid methyl ester
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00045
1,1,1,3,3,3-hexafluoro-2-(2-phenoxy-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000016
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(2H-tetrazol-2-yl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000024
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(methylsulfonyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.00024 - 0.00032
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
0.000044
1,1,1,3,3,3-hexafluoro-2-(2-[4-[4-(methylsulfonyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.00011
1,1,1,3,3,3-hexafluoro-2-(2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000057
1,1,1,3,3,3-hexafluoro-2-(2-[[4-(trifluoromethyl)phenyl]sulfonyl]-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000209
1,1,1,3,3,3-hexafluoro-2-(4-[(5E)-2-(1-methylethyl)-5-[(phenylperoxy)imino]-4,5-dihydro-1H-imidazol-1-yl]phenyl)propan-2-ol
Rattus norvegicus
-
-
0.000149
1,1,1,3,3,3-hexafluoro-2-(4-[5-(1-hydroxyethyl)-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
Rattus norvegicus
-
-
0.000274
1,1,1,3,3,3-hexafluoro-2-(4-[5-(hydroxymethyl)-2-(1-methylethyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
Rattus norvegicus
-
-
0.000114
1,1,1,3,3,3-hexafluoro-2-(4-[5-(hydroxymethyl)-2-pyridin-4-yl-1H-imidazol-1-yl]phenyl)propan-2-ol
Rattus norvegicus
-
-
0.000465
1,1,1,3,3,3-hexafluoro-2-(4-[5-[hydroxy(phenoxy)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)propan-2-ol
Rattus norvegicus
-
-
0.000037
1,1,1,3,3,3-hexafluoro-2-[2-(1-phenylpiperidin-4-yl)-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.00002
1,1,1,3,3,3-hexafluoro-2-[2-(4-phenylpiperazin-1-yl)-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000013
1,1,1,3,3,3-hexafluoro-2-[2-(4-phenylpiperidin-1-yl)-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000092
1,1,1,3,3,3-hexafluoro-2-[2-[(4-methylphenyl)sulfanyl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000036
1,1,1,3,3,3-hexafluoro-2-[2-[1-(3-fluorophenyl)piperidin-4-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000019
1,1,1,3,3,3-hexafluoro-2-[2-[1-(4-fluorophenyl)piperidin-4-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000016
1,1,1,3,3,3-hexafluoro-2-[2-[4-(2-fluorophenyl)-4-(2H-tetrazol-2-yl)piperidin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000087
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-fluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000011
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-fluorophenyl)piperidin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000046
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-methoxyphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000012
1,1,1,3,3,3-hexafluoro-2-[2-[4-(3-nitrophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000081
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-fluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000076
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-methoxyphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000059
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-methylphenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000089
1,1,1,3,3,3-hexafluoro-2-[2-[4-(4-nitrophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0006
1,1,1,3,3,3-hexafluoro-2-[4-[(4-methylphenyl)sulfanyl]phenyl]propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000155
1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-([[5-(1H-tetrazol-5-yl)pentyl]oxy]methyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
Rattus norvegicus
-
-
0.000116
1,1,1,3,3,3-hexafluoro-2-[4-[2-(1-methylethyl)-5-[[4-(1H-tetrazol-5-yl)butoxy]methyl]-1H-imidazol-1-yl]phenyl]propan-2-ol
Rattus norvegicus
-
-
0.00034
1,1,1,3,3,3-hexafluoro-2-[4-[5-[[(2-methoxyethyl)amino]methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl]propan-2-ol
Rattus norvegicus
-
-
0.00006
1,3-diethyl-3-(4-hydroxybutyl)-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000037
1,3-dimethyl-1-(2-methylpropyl)butyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.00009
1,3-dimethyl-1-(2-methylpropyl)butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-beta-alaninate
Rattus norvegicus
-
-
0.000005
1-ethyl-1-methylpropyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.000007
1-ethyl-1-methylpropyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-beta-alaninate
Rattus norvegicus
-
-
0.000059
1-ethyl-3,3-dimethyl-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00006
1-ethyl-3-(4-hydroxybutyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)urea
Rattus norvegicus
-
-
0.000059
1-ethyl-3-methyl-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)urea
Rattus norvegicus
-
-
0.001564
1-methyl-3-phenyl-1-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]urea
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00633
1-[3-(4-hydroxyphenyl)-5-(thiophen-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Homo sapiens
at pH 8.0 and 30°C
0.0000033
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenyl-N-(2,2,2-trifluoroethyl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000045
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidin-4-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000011
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carbonitrile
Homo sapiens
-
pH and temperature not specified in the publication
0.0000049
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000011
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-4-phenylpiperidine-4-carboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0000009
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-N-(methylsulfonyl)-4-phenylpiperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000047
1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-N-methyl-4-phenylpiperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0059
1-[5-(2,4-dibromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Homo sapiens
at pH 8.0 and 30°C
0.00658
1-[5-(2,4-dichlorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Homo sapiens
at pH 8.0 and 30°C
0.00365
1-[5-(2,4-difluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Homo sapiens
at pH 8.0 and 30°C
0.00768
1-[5-(2,4-dimethoxyphenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-l]ethanone
Homo sapiens
at pH 8.0 and 30°C
0.00026
1-[5-(3,4-dibromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Homo sapiens
at pH 8.0 and 30°C
0.00347
1-[5-(3,4-dichlorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Homo sapiens
at pH 8.0 and 30°C
0.00442
1-[5-(4-chlorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Homo sapiens
at pH 8.0 and 30°C
0.05
1-[5-(4-hydroxyphenyl)-3-(thiophen-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Homo sapiens
IC50 above 0.05 mM, at pH 8.0 and 30°C
0.00697
1-[5-(furan-3-yl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
Homo sapiens
at pH 8.0 and 30°C
0.00328
2,2,2-trifluoro-1-[4-(pyrrolidin-1-ylcarbonyl)phenyl]ethanone
Rattus norvegicus
-
-
0.0000133
2-(4-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-4-yl)ethyl]-3-methylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.00046
2-(4-[5-amino-3-(1-methylethyl)isoxazol-4-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Rattus norvegicus
-
-
0.000303
2-(4-[5-[(butylamino)methyl]-2-(1-methylpropyl)-1H-imidazol-1-yl]phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Rattus norvegicus
-
-
0.0002
2-ethyl-N-[3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazol-5-yl]hexanamide
Rattus norvegicus
-
-
0.000059
2-methyl-1-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]propan-1-ol
Rattus norvegicus
-
-
0.000225
2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoic acid
Rattus norvegicus
-
-
0.000042
2-methyl-N-(pyridin-4-ylmethyl)-N-[5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl]propanamide
Rattus norvegicus
-
-
0.00545
2-methyl-N-[4-(trifluoroacetyl)phenyl]propanamide
Rattus norvegicus
-
-
0.006626
2-phenoxy-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]acetamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.0015
2-phenoxy-N-[4-(trifluoroacetyl)phenyl]acetamide
Rattus norvegicus
-
-
0.0000017
2-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000074
2-[2-(1-methylpropyl)-5-propyl-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]ethenone
Rattus norvegicus
-
-
0.000011
2-[2-[4-(3,4-difluorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000032
2-[2-[4-(3-aminophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000079
2-[2-[4-(3-chlorophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000027
2-[2-[4-(4-aminophenyl)piperazin-1-yl]-1,3-thiazol-5-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.00225
2-[3-(4-hydroxyphenyl)-5-(4-methoxy-2-nitrophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00355
2-[3-(4-hydroxyphenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.0016
2-[3-(4-hydroxyphenyl)-5-(thiophen-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00203
2-[3-(4-hydroxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00041
2-[4-(3,5-dimethylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
Rattus norvegicus
-
-
0.0000051
2-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.00765
2-[5-(2,4-dibromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00204
2-[5-(2,4-dinitrophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00027
2-[5-(3,4-difluorophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00308
2-[5-(3,5-dimethoxyphenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00152
2-[5-(4-bromophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00192
2-[5-(4-nitrophenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.0001
2-[5-(furan-3-yl)-3-(4-hydroxy-3,5-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00223
2-[5-(furan-3-yl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.00234
2-[5-(pyridin-2-yl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one
Homo sapiens
at pH 8.0 and 30°C
0.000247
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid
0.000099
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid methyl ester
0.00034
3-(1-methylethyl)-N-pyridin-4-yl-4(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-5-carboxamide
Rattus norvegicus
-
-
0.00042
3-(1-methylethyl)-N-[(2E)-3-phenylprop-2-en-1-yl]-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazole-5-carboxamide
Rattus norvegicus
-
-
0.0028
3-(2-methylpropyl)-1-propyl-1-[4-(trifluoroacetyl)phenyl]urea
Rattus norvegicus
-
-
0.00008
3-nitrophenyl 3-[(2-methylpropyl)(phenylcarbonyl)amino]propaneperoxoyl-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.004337
3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.0000031
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]-N-methylbenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000018
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000009
3-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000239
3-[2-(1-methylethyl)-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazol-5-yl]propanoic acid
Rattus norvegicus
-
-
0.000163
3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoic acid
Rattus norvegicus
-
-
0.0000005
3-[4-carbamoyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0000023
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]-N-methylbenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000022
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000013
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000016
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzonitrile
Homo sapiens
-
pH and temperature not specified in the publication
0.000014
3-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-1-yl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000075
4-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)butyric acid methyl ester
0.0000133
4-(2-amino-1,3-thiazol-4-yl)-7-[[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]sulfanyl]-2H-chromen-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0000006
4-(3-carboxyphenyl)-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0000014
4-(4-fluorophenyl)-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000507
4-(trifluoroacetyl)-N-[3-(trifluoromethyl)phenyl]benzamide
Rattus norvegicus
-
-
0.000037
4-cyano-N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]benzamide
0.0049
4-cyano-N-[4-(trifluoroacetyl)phenyl]benzamide
Rattus norvegicus
-
-
0.0000004
4-cyclohexyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0000034
4-cyclopropyl-1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000004
4-[1-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperidin-4-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000019
4-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000042
4-[4-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]benzonitrile
Homo sapiens
-
pH and temperature not specified in the publication
0.000014
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000042
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
0.000008
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
0.00002 - 0.000026
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
0.00039
5-methyl-N-pyridin-4-yl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-3-carboxamide
Rattus norvegicus
-
-
0.000107
5-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]pentanenitrile
Rattus norvegicus
-
-
0.000168
6-[[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-1H-imidazol-5-yl]methoxy]hexanenitrile
Rattus norvegicus
-
-
0.000318
ethyl 2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazole-4-carboxylate
Rattus norvegicus
-
-
0.000037
ethyl 2-methyl-3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate
Rattus norvegicus
-
-
0.000191
ethyl 2-pyridin-4-yl-1-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)-4,5-dihydro-1H-imidazole-4-carboxylate
Rattus norvegicus
-
-
0.000463
ethyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
Rattus norvegicus
-
-
0.000421
ethyl 4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.001767
ethyl [((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]acetate
Rattus norvegicus
-
-
4.1
L-malate
Homo sapiens
-
in 40 mM Tris, pH 8.0
0.000088
methyl (2E)-3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]prop-2-enoate
Rattus norvegicus
-
-
0.000065
methyl 3-[2-(1-methylethyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate
Rattus norvegicus
-
-
0.000041
methyl 3-[2-(1-methylpropyl)-1-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4,5-dihydro-1H-imidazol-5-yl]propanoate
Rattus norvegicus
-
-
0.000054
methyl 4-[(2-methylpropanoyl)[5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl]amino]benzoate
Rattus norvegicus
-
-
0.00114
morpholin-4-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000166
morpholine-4-carboxylic acid (2-hydroxyethyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.00004
morpholine-4-carboxylic acid (3-cyanopropyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.00003
morpholine-4-carboxylic acid butyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.000074
morpholine-4-carboxylic acid ethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.000073
morpholine-4-carboxylic acid heptyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.000031
morpholine-4-carboxylic acid hexyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.000321
morpholine-4-carboxylic acid methyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.000269
morpholine-4-carboxylic acid octyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000019
morpholine-4-carboxylic acid pentyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.000043
morpholine-4-carboxylic acid phenethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.000034
morpholine-4-carboxylic acid propyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
0.000073
N,N-bis(2-methylpropyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.001619
N,N-diethyl-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.00007
N,N-diisobutyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
0.000153
N,N-dipropyl-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000242
N-(1,3-dimethylbutyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.00025
N-(1-methylethyl)-3-pyridin-4-yl-4-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)isoxazole-5-carboxamide
Rattus norvegicus
-
-
0.003361
N-(1-methylethyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000801
N-(1-methylethyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
Rattus norvegicus
-
-
0.000137
N-(1-methylethyl)-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
Rattus norvegicus
-
-
0.001731
N-(1-methylethyl)-N-phenyl-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000115
N-(1-methylhexyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.00029
N-(2-cyanoethyl)-N-ethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
0.000214
N-(2-cyanoethyl)-N-ethyl-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000155
N-(2-cyanoethyl)-N-phenoxy-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.001147
N-(2-dimethylaminoethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000106
N-(2-hydroxyethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000304
N-(2-methylcyclohexyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000068
N-(2-methylcyclopropyl)-N-propyl-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.001531
N-(2-methylpropyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000566
N-(2-phenoxyethyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.002753
N-(3,3-dimethylbutyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000489
N-(3,3-dimethylbutyl)-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
Rattus norvegicus
-
-
0.001351
N-(3-phenoxypropyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000028
N-(3-tert-butoxypropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
Rattus norvegicus
-
-
0.00002
N-(4-cyanobutyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00002
N-(4-cyanophenyl)-2-methyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)propanamide
Rattus norvegicus
-
-
0.00039
N-(4-cyanophenyl)-3-(1-methylethyl)-4-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]isoxazole-5-carboxamide
Rattus norvegicus
-
-
0.001739
N-(4-phenoxybutyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000028
N-(6-methylheptyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
Rattus norvegicus
-
-
0.000304 - 0.002298
N-(cyclohexylmethyl)-4-(trifluoroacetyl)benzamide
0.000117
N-(cyclopropylmethyl)-6-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]pyridine-3-carboxamide
Rattus norvegicus
-
-
0.002034
N-(furan-2-ylmethyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.00058
N-benzyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.001
N-benzyl-N-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000079
N-butyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000177
N-butyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)acetamide
Rattus norvegicus
-
-
0.000111
N-butyl-N-(5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl)pyridine-4-carboxamide
Rattus norvegicus
-
-
0.00002
N-butyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
0.00015
N-cyclohexyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
0.000175
N-ethyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000399
N-ethyl-N-(2-hydroxy-2-methylpropyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.001105
N-ethyl-N-(2-methoxyethyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000041
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
0.000095
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
0.00006
N-heptyl-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
Rattus norvegicus
-
-
0.000679
N-hexyl-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000199
N-isopropyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00145
N-methoxy-N-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00093
N-methyl-2-phenoxy-N-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)acetamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.0045
N-methyl-2-phenoxy-N-[4-(trifluoroacetyl)phenyl]acetamide
Rattus norvegicus
-
-
0.000814
N-methyl-2-phenoxy-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]acetamide
Homo sapiens
-
in 40 mM Tris, pH 8.0
0.000773
N-methyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000676
N-methyl-N-(1-methylethyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
Rattus norvegicus
-
-
0.000953
N-methyl-N-(2-phenoxyethyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000394
N-methyl-N-(4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)pyridine-4-carboxamide
Rattus norvegicus
-
-
0.00199
N-methyl-N-phenethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000178
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
0.000394
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.001015
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]nicotinamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00265
N-phenethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl) benzamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000028
N-propyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
0.005011
N-[(2-hydroxyphenoxy)methyl]-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000654
N-[3,5-bis(trifluoromethyl)phenyl]-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.000017
N-[3-[bis(1-methylethyl)amino]-3-oxopropyl]-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
Rattus norvegicus
-
-
0.000008
N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
0.0172
N-[4-(trifluoroacetyl)phenyl]morpholine-4-carboxamide
Rattus norvegicus
-
-
2.2
NAD+
Homo sapiens
-
in 40 mM Tris, pH 8.0
0.00098
piperidin-1-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00085
pyrrolidin-1-yl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]methanone
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000008
tert-butyl (3R)-3-[(((5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.000168
tert-butyl (3R)-3-[(((5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.00001
tert-butyl (3R)-3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.000045
tert-butyl (3R)-5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
Rattus norvegicus
-
-
0.000005
tert-butyl (3S)-3-[(((5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.000136
tert-butyl (3S)-3-[(((5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.000007
tert-butyl (3S)-3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.000009
tert-butyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
Homo sapiens
-
in 40 mM Tris, pH 8.0
0.000015
tert-butyl (3S)-5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
Rattus norvegicus
-
-
0.000023
tert-butyl 3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
Rattus norvegicus
-
-
0.000031
tert-butyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
Rattus norvegicus
-
-
0.00003
tert-butyl 5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
Rattus norvegicus
-
-
0.000113
tert-butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)leucinate
Rattus norvegicus
-
-
0.00024
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.00032
1,1,1,3,3,3-hexafluoro-2-(2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-thiazol-5-yl)propan-2-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.000247
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid
Rattus norvegicus
-
-
0.000247
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000099
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid methyl ester
Rattus norvegicus
-
-
0.000099
3-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)propionic acid methyl ester
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000075
4-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)butyric acid methyl ester
Rattus norvegicus
-
-
0.000075
4-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)butyric acid methyl ester
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000037
4-cyano-N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]benzamide
Rattus norvegicus
-
-
0.000037
4-cyano-N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]benzamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000042
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
Rattus norvegicus
-
-
0.000042
5-((morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000008
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
Rattus norvegicus
-
-
0.000008
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00002
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
Rattus norvegicus
-
-
0.000026
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
Rattus norvegicus
-
-
0.000026
5-(isobutyryl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amino)pentanoic acid methyl ester
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000166
morpholine-4-carboxylic acid (2-hydroxyethyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Rattus norvegicus
-
-
0.000166
morpholine-4-carboxylic acid (2-hydroxyethyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00004
morpholine-4-carboxylic acid (3-cyanopropyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Rattus norvegicus
-
-
0.00004
morpholine-4-carboxylic acid (3-cyanopropyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00003
morpholine-4-carboxylic acid butyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Rattus norvegicus
-
-
0.00003
morpholine-4-carboxylic acid butyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000074
morpholine-4-carboxylic acid ethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Rattus norvegicus
-
-
0.000074
morpholine-4-carboxylic acid ethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000073
morpholine-4-carboxylic acid heptyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Rattus norvegicus
-
-
0.000073
morpholine-4-carboxylic acid heptyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000031
morpholine-4-carboxylic acid hexyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Rattus norvegicus
-
-
0.000031
morpholine-4-carboxylic acid hexyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000321
morpholine-4-carboxylic acid methyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Rattus norvegicus
-
-
0.000321
morpholine-4-carboxylic acid methyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000019
morpholine-4-carboxylic acid pentyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Rattus norvegicus
-
-
0.000019
morpholine-4-carboxylic acid pentyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000043
morpholine-4-carboxylic acid phenethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Rattus norvegicus
-
-
0.000043
morpholine-4-carboxylic acid phenethyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000034
morpholine-4-carboxylic acid propyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Rattus norvegicus
-
-
0.000034
morpholine-4-carboxylic acid propyl-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]amide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00007
N,N-diisobutyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
Rattus norvegicus
-
-
0.00007
N,N-diisobutyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00029
N-(2-cyanoethyl)-N-ethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
Rattus norvegicus
-
-
0.00029
N-(2-cyanoethyl)-N-ethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000304
N-(cyclohexylmethyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.002298
N-(cyclohexylmethyl)-4-(trifluoroacetyl)benzamide
Rattus norvegicus
-
-
0.00002
N-butyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Rattus norvegicus
-
-
0.00002
N-butyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.00015
N-cyclohexyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Rattus norvegicus
-
-
0.00015
N-cyclohexyl-3-phenyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]propionamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000041
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Rattus norvegicus
-
-
0.000041
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000095
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
Rattus norvegicus
-
-
0.000095
N-ethyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isonicotinamide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000178
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Rattus norvegicus
-
-
0.000178
N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000028
N-propyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Rattus norvegicus
-
-
0.000028
N-propyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
0.000008
N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Rattus norvegicus
-
-
0.000008
N-[4-(1H-tetrazol-5-yl)butyl]-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]isobutyramide
Homo sapiens
-
in 10 mM phosphate buffered saline, pH 7.4, 0.05% Tween-20, 25 mM K2HPO4-KH2PO4
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Scholte, H.R.
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1971
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Liver malonyl-CoA decarboxylase
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Bos taurus
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Koeppen, A.H.; Mitzen, E.J.; Ammoumi, A.A.
Malonate metabolism in rat brain mitochondria
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1974
Rattus norvegicus
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Buckner, J.S.; Kolattukudy, P.E.; Poulose, A.J.
Purification and properties of malonyl-coenzyme A decarboxylase, a regulatory enzyme from the uropygial gland of goose
Arch. Biochem. Biophys.
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1976
Anser sp.
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Kresze, G.B.; Steber, L.; Oesterhelt, D.; Lynen, F.
Reaction of fatty acid synthetase with iodoacetamide. 3. Malonyl-coenzyme A decarboxylase as product of the reaction of fatty acid synthetase with iodoacetamide
Eur. J. Biochem.
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1977
Saccharomyces cerevisiae
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Kim, Y.S.; Kolattukudy, P.E.
Purification and properties of malonyl-CoA decarboxylase from rat liver mitochondria and its immunological comparison with the enzymes from rat brain, heart, and mammary gland
Arch. Biochem. Biophys.
190
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1978
Rattus norvegicus
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Kim, Y.S.; Kolattukudy, P.E.
Malonyl-CoA decarboxylase from the uropygial gland of waterfowl: purification, properties, immunological comparison, and role in regulating the synthesis of multimethyl-branched fatty acids
Arch. Biochem. Biophys.
190
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1978
Aix sponsa, Anas platyrhynchos, Anser domesticus, Branta leucopsis, Cairina moschata
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Malonyl-CoA decarboxylase from the mammary gland of lactating rat. Purification, properties and subcellular localization
Biochim. Biophys. Acta
531
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1978
Rattus norvegicus
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Malonyl-CoA decarboxylase from Mycobacterium tuberculosis and Pseudomonas fluorescence
Arch. Biochem. Biophys.
196
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1979
Mycobacterium tuberculosis, Pseudomonas fluorescens, Mycobacterium tuberculosis H37Ra / ATCC 25177
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Stereospecificity of malonyl-CoA decarboxylase, acetyl-CoA carboxylase, and fatty acid synthetase from uropygial gland of goose
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1980
Anser sp.
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Malonyl-CoA decarboxylase from avian, mammalian, and microbial sources
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1981
Aix sponsa, Anser sp., Cairina moschata, Mycobacterium tuberculosis, Rattus norvegicus, Mycobacterium tuberculosis H37Ra / ATCC 25177
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Mechanism of action of cerulenin on fatty acid synthetase. Effect of cerulenin on iodoacetamide-induced malonyl-CoA decarboxylase
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1982
Saccharomyces cerevisiae
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Malonyl-CoA decarboxylase from Streptomyces erythreus: purification, properties, and possible role in the production of erythromycin
Arch. Biochem. Biophys.
229
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1984
Saccharopolyspora erythraea
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Developmental pattern of the expression of malonyl-CoA decarboxylase gene and the production of unique lipids in the goose uropygial glands
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256
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1987
Anser sp.
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Cytoplasmic accumulation of a normally mitochondrial malonyl decarboxylase by the use of an alternate transcription site
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298
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1992
Anser sp.
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Inhibition of erythromycin synthesis by disruption of malonyl-coenzyme A decarboxylase gene eryM in Saccharopolyspora erythraea
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1998
Rattus norvegicus
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1989
Anser sp.
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The cellular localization of malonyl-coenzyme A decarboxylase in rat brain
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1994
Rattus norvegicus
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Decarboxylation of malonyl-CoA by lactating bovine mammary fatty acid synthase
Comp. Biochem. Physiol. B
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1988
Bos taurus
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Purification and some properties of malonate decarboxylase from Pseudomonas ovalis: an oligomeric enzyme with bifunctional properties
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1981
Pseudomonas putida
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1992
Citrobacter koseri
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Malonate decarboxylase of Pseudomonas putida is composed of five subunits
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1998
Pseudomonas putida
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CoA transferase and malonyl-CoA decarboxylase activity of malonate decarboxylase from Acinetobacter calcoaceticus
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Acinetobacter calcoaceticus
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Crystallization and preliminary X-ray crystallographic analysis of malonyl-CoA decarboxylase from Rhizobium leguminosarum bv. trifolii
Acta Crystallogr. Sect. D
59
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2003
Rhizobium leguminosarum (Q9ZIP6), Rhizobium leguminosarum
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Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids
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280
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2001
Rattus norvegicus
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Contribution of malonyl-CoA decarboxylase to the high fatty acid oxidation rates seen in the diabetic heart
Am. J. Physiol. Heart Circ. Physiol.
278
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2000
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Radiochemical malonyl-CoA decarboxylase assay: activity and subcellular distribution in heart and skeletal muscle
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Cloning and expression of rat pancreatic beta-cell malonyl-CoA decarboxylase
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Characterization of rat liver malonyl-CoA decarboxylase and the study of its role in regulating fatty acid metabolism
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2000
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Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level
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Properties of malonyl-CoA decarboxylase from Rhizobium trifolii
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1999
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Rat malonyl-CoA decarboxylase; cloning, expression in E. coli and its biochemical characterization
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2002
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Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside
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275
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2000
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Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells
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276
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2001
Homo sapiens
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Campbell, F.M.; Kozak, R.; Wagner, A.; Altarejos, J.Y.; Dyck, J.R.B.; Belke, D.D.; Severson, D.L.; Kelly, D.P.; Lopaschuk, G.D.
A role for peroxisome proliferator-activated receptor alpha (PPARalpha) in the control of cardiac malonyl-CoA levels. Reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase
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2002
Mus musculus
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Gao, J.; Waber, L.; Bennett, M.J.; Gibson, K.M.; Cohen, J.C.
Cloning and mutational analysis of human malonyl-coenzyme A decarboxylase
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1999
Homo sapiens
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Zhou, D.; Yuen, P.; Chu, D.; Thon, V.; McConnell, S.; Brown, S.; Tsang, A.; Pena, M.; Russell, A.; Cheng, J.F.; Nadzan, A.M.; Barbosa, M.S.; Dyck, J.R.B.; Lopaschuk, G.D.; Yang, G.
Expression, purification, and characterization of human malonyl-CoA decarboxylase
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34
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2004
Homo sapiens
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Kuhl, J.E.; Ruderman, N.B.; Musi, N.; Goodyear, L.J.; Patti, M.E.; Crunkhorn, S.; Dronamraju, D.; Thorell, A.; Nygren, J.; Ljungkvist, O.; Degerblad, M.; Stahle, A.; Brismar, T.B.; Andersen, K.L.; Saha, A.K.; Efendic, S.; Bavenholm, P.N.
Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle
Am. J. Physiol. Endocrinol. Metab.
290
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2006
Homo sapiens
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Wang, X.; Stanley, W.C.; Brunengraber, H.; Kasumov, T.
Assay of the activity of malonyl-coenzyme A decarboxylase by gas chromatography-mass spectrometry
Anal. Biochem.
363
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2007
Rattus norvegicus
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Patel, M.R.; Talele, T.T.
3D-QSAR studies on malonyl coenzyme A decarboxylase inhibitors
Bioorg. Med. Chem.
15
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2007
Rattus norvegicus
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Wallace, D.M.; Haramura, M.; Cheng, J.F.; Arrhenius, T.; Nadzan, A.M.
Novel trifluoroacetophenone derivatives as malonyl-CoA decarboxylase inhibitors
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17
1127-1130
2007
Rattus norvegicus
brenda
Kim, H.J.; Zhao, Z.S.; Lee, Y.J.; Shim, W.S.; Kim, S.K.; Ahn, C.W.; Park, C.W.; Lee, H.C.; Cha, B.S.
Tissue-specific regulation of malonyl-CoA decarboxylase activity in OLETF rats
Diabetes Obes. Metab.
8
175-183
2006
Rattus norvegicus
brenda
Cheng, J.F.; Chen, M.; Wallace, D.; Tith, S.; Haramura, M.; Liu, B.; Mak, C.C.; Arrhenius, T.; Reily, S.; Brown, S.; Thorn, V.; Harmon, C.; Barr, R.; Dyck, J.R.; Lopaschuk, G.D.; Nadzan, A.M.
Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors
J. Med. Chem.
49
1517-1525
2006
Homo sapiens
brenda
Cheng, J.F.; Huang, Y.; Penuliar, R.; Nishimoto, M.; Liu, L.; Arrhenius, T.; Yang, G.; Oleary, E.; Barbosa, M.; Barr, R.; Dyck, J.R.; Lopaschuk, G.D.; Nadzan, A.M.
Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents
J. Med. Chem.
49
4055-4058
2006
Rattus norvegicus
brenda
Nam, H.W.; Lee, G.Y.; Kim, Y.S.
Mass spectrometric identification of K210 essential for rat malonyl-CoA decarboxylase catalysis
J. Proteome Res.
5
1398-1406
2006
Rattus norvegicus
brenda
Lo, M.C.; Wang, M.; Kim, K.W.; Busby, J.; Yamane, H.; Zondlo, J.; Yuan, C.; Young, S.W.; Xiao, S.H.
A highly sensitive high-throughput luminescence assay for malonyl-CoA decarboxylase
Anal. Biochem.
376
122-130
2008
Homo sapiens
brenda
Saggerson, D.
Malonyl-CoA, a key signaling molecule in mammalian cells
Annu. Rev. Nutr.
28
253-272
2008
Homo sapiens
brenda
Ussher, J.R.; Lopaschuk, G.D.
The malonyl CoA axis as a potential target for treating ischaemic heart disease
Cardiovasc. Res.
79
259-268
2008
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Koves, T.R.; Ussher, J.R.; Noland, R.C.; Slentz, D.; Mosedale, M.; Ilkayeva, O.; Bain, J.; Stevens, R.; Dyck, J.R.; Newgard, C.B.; Lopaschuk, G.D.; Muoio, D.M.
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
Cell Metab.
7
45-56
2008
Mus musculus
brenda
Lopez, M.; Vidal-Puig, A.
Brain lipogenesis and regulation of energy metabolism
Curr. Opin. Clin. Nutr. Metab. Care
11
483-490
2008
Homo sapiens
brenda
Bouzakri, K.; Austin, R.; Rune, A.; Lassman, M.E.; Garcia-Roves, P.M.; Berger, J.P.; Krook, A.; Chibalin, A.V.; Zhang, B.B.; Zierath, J.R.
Malonyl coenzyme A decarboxylase regulates lipid and glucose metabolism in human skeletal muscle
Diabetes
57
1508-1516
2008
Homo sapiens
brenda
Lane, M.D.; Wolfgang, M.; Cha, S.; Dai, Y.
Regulation of food intake and energy expenditure by hypothalamic malonyl-CoA
Int. J. Obes.
32
S49-S54
2008
Mus musculus
-
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Pimenta, A.S.; Gaidhu, M.P.; Habib, S.; So, M.; Fediuc, S.; Mirpourian, M.; Musheev, M.; Curi, R.; Ceddia, R.B.
Prolonged exposure to palmitate impairs fatty acid oxidation despite activation of AMP-activated protein kinase in skeletal muscle cells
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2008
Rattus norvegicus
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Li, J.; Lei, B.; Liu, H.; Li, S.; Yao, X.; Liu, M.; Gramatica, P.
QSAR study of malonyl-CoA decarboxylase inhibitors using GA-MLR and a new strategy of consensus modeling
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2008
Homo sapiens
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Yatscoff, M.A.; Jaswal, J.S.; Grant, M.R.; Greenwood, R.; Lukat, T.; Beker, D.L.; Rebeyka, I.M.; Lopaschuk, G.D.
Myocardial hypertrophy and the maturation of fatty acid oxidation in the newborn human heart
Pediatr. Res.
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2008
Homo sapiens
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Singh, P.; Kumar, R.; Sharma, B.; Prabhakar, Y.
Topological descriptors in modeling malonyl coenzyme A decarboxylase inhibitory activity: N-alkyl-N-(1,1,1,3,3,3-hexafluoro-2-hydroxypropylphenyl) amide derivatives
J. Enzyme Inhib. Med. Chem.
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2009
Homo sapiens
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Zhou, W.; Tu, Y.; Simpson, P.J.; Kuhajda, F.P.
Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells
Oncogene
28
2979-2987
2009
Homo sapiens
brenda
Robbel, L.; Helmetag, V.; Knappe, T.A.; Marahiel, M.A.
Consecutive enzymatic modification of ornithine generates the hydroxamate moieties of the siderophore erythrochelin
Biochemistry
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6073-6080
2011
Saccharopolyspora erythraea
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Tang, H.; Yan, Y.; Feng, Z.; de Jesus, R.K.; Yang, L.; Levorse, D.A.; Owens, K.A.; Akiyama, T.E.; Bergeron, R.; Castriota, G.A.; Doebber, T.W.; Ellsworth, K.P.; Lassman, M.E.; Li, C.; Wu, M.S.; Zhang, B.B.; Chapman, K.T.; Mills, S.G.; Berger, J.P.; Pasternak, A.
Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities
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2010
Homo sapiens
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Samokhvalov, V.; Ussher, J.R.; Fillmore, N.; Armstrong, I.K.; Keung, W.; Moroz, D.; Lopaschuk, D.G.; Seubert, J.; Lopaschuk, G.D.
Inhibition of malonyl-CoA decarboxylase reduces the inflammatory response associated with insulin resistance
Am. J. Physiol. Endocrinol. Metab.
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2012
Mus musculus
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Polinati, P.P.; Valanne, L.; Tyni, T.
Malonyl-CoA decarboxylase deficiency: long-term follow-up of a patient new clinical features and novel mutations
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2015
Homo sapiens (O95822)
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Aparicio, D.; Perez-Luque, R.; Carpena, X.; Diaz, M.; Ferrer, J.C.; Loewen, P.C.; Fita, I.
Structural asymmetry and disulfide bridges among subunits modulate the activity of human malonyl-CoA decarboxylase
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Homo sapiens (O95822), Homo sapiens
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Froese, D.S.; Forouhar, F.; Tran, T.H.; Vollmar, M.; Kim, Y.S.; Lew, S.; Neely, H.; Seetharaman, J.; Shen, Y.; Xiao, R.; Acton, T.B.; Everett, J.K.; Cannone, G.; Puranik, S.; Savitsky, P.; Krojer, T.; Pilka, E.S.; Kiyani, W.; Lee, W.H.; Marsden, B.D.; von Delft, F.; Allerston, C.K.; Spagnolo, L.; Gileadi, O.; , M.
Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations
Structure
21
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2013
Agrobacterium vitis (B9K0V9), Agrobacterium vitis, Cupriavidus metallidurans (Q1LJK6), Cupriavidus metallidurans, Cupriavidus metallidurans CH34 (Q1LJK6), Homo sapiens (O95822), Homo sapiens, Rhodopseudomonas palustris
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Hwang, I.W.; Makishima, Y.; Suzuki, T.; Kato, T.; Park, S.; Terzic, A.; Chung, S.K.; Park, E.Y.
Phosphorylation of Ser-204 and Tyr-405 in human malonyl-CoA decarboxylase expressed in silkworm Bombyx mori regulates catalytic decarboxylase activity
Appl. Microbiol. Biotechnol.
99
8977-8986
2015
Homo sapiens (O95822), Homo sapiens
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Rodriguez, S.; Ellis, J.M.; Wolfgang, M.J.
Chemical-genetic induction of malonyl-CoA decarboxylase in skeletal muscle
BMC Biochem.
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2014
Mus musculus (Q99J39), Mus musculus
brenda
Wu, H.; Zhu, Q.; Cai, M.; Tong, X.; Liu, D.; Huang, J.; Yang, G.; Jiang, Y.
Effect of inhibiting malonyl-CoA decarboxylase on cardiac remodeling after myocardial infarction in rats
Cardiology
127
236-244
2014
Rattus norvegicus (Q920F5)
brenda
Ussher, J.R.; Fillmore, N.; Keung, W.; Zhang, L.; Mori, J.; Sidhu, V.K.; Fukushima, A.; Gopal, K.; Lopaschuk, D.G.; Wagg, C.S.; Jaswal, J.S.; Dyck, J.R.; Lopaschuk, G.D.
Genetic and pharmacological inhibition of malonyl CoA decarboxylase does not exacerbate age-related insulin resistance in mice
Diabetes
65
1883-1891
2016
Mus musculus (Q99J39), Mus musculus
brenda
Jagdale, D.; Ramaa, C.
Design, synthesis and in vitro evaluation of some small molecules malonyl CoA decarboxylase inhibitors containing pyrazoline scaffold and study of their binding interactions with malonyl CoA decarboxylase via preliminary docking simulation
Med. Chem. Res.
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2127-2140
2017
Homo sapiens (O95822)
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brenda
Ling, B.; Liu, Y.; Li, X.; Wang, Z.; Bi, S.
Identification of the active site of human mitochondrial malonyl-coenzyme A decarboxylase A combined computational study
Proteins
84
792-802
2016
Homo sapiens (O95822), Homo sapiens
brenda