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(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium + CO2
S-adenosyl-L-methionine + H+
-
-
-
-
?
Adenosylethionine
?
-
poor substrate
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium salt + CO2
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
S-adenosyl-L-methionine
?
S-adenosyl-L-methionine
S-adenosyl 3-(methylthio)propylamine + CO2
additional information
?
-
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
high specificity
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
the crenarchaeal S-adenosylmethionine decarboxylase has no arginine decarboxylase activity
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
the crenarchaeal S-adenosylmethionine decarboxylase has no arginine decarboxylase activity
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
A5HNV7
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
-
?
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
-
-
?
S-adenosyl-L-methionine
?
-
key enzyme in the biosynthetic pathway for spermidine and spermine
-
-
?
S-adenosyl-L-methionine
?
-
the enzyme protein turns over very rapidly in growing or differentiating tissues
-
-
?
S-adenosyl-L-methionine
?
-
key enzyme in the biosynthetic pathway for spermidine and spermine
-
-
?
S-adenosyl-L-methionine
?
-
key enzyme in the biosynthetic pathway for spermidine and spermine
-
-
?
S-adenosyl-L-methionine
?
-
key enzyme in polyamine biosynthesis
-
-
?
S-adenosyl-L-methionine
?
-
the enzyme protein turns over very rapidly in growing or differentiating tissues
-
-
?
S-adenosyl-L-methionine
?
-
key enzyme in the biosynthetic pathway for spermidine and spermine
-
-
?
S-adenosyl-L-methionine
?
-
-
-
?
S-adenosyl-L-methionine
?
-
key enzyme in the biosynthetic pathway for spermidine and spermine
-
-
?
S-adenosyl-L-methionine
?
-
major regulatory enzyme in polyamine biosynthesis
-
-
?
S-adenosyl-L-methionine
?
-
key enzyme in polyamine biosynthesis
-
-
?
S-adenosyl-L-methionine
?
-
the enzyme protein turns over very rapidly in growing or differentiating tissues
-
-
?
S-adenosyl-L-methionine
?
-
key enzyme in polyamine biosynthesis
-
-
?
S-adenosyl-L-methionine
?
-
key enzyme in the biosynthetic pathway for spermidine and spermine
-
-
?
S-adenosyl-L-methionine
?
-
the enzyme protein turns over very rapidly in growing or differentiating tissues
-
-
?
S-adenosyl-L-methionine
?
-
major regulatory enzyme in polyamine biosynthesis
-
-
?
S-adenosyl-L-methionine
?
-
key enzyme in the biosynthetic pathway for spermidine and spermine
-
-
?
S-adenosyl-L-methionine
?
-
EC 4.1.1.50 and EC 2.5.1.16 appear to function in sequence in animals and microorganisms in the synthesis of spermidine
-
-
?
S-adenosyl-L-methionine
S-adenosyl 3-(methylthio)propylamine + CO2
-
-
-
-
?
S-adenosyl-L-methionine
S-adenosyl 3-(methylthio)propylamine + CO2
-
-
-
-
?
S-adenosyl-L-methionine
S-adenosyl 3-(methylthio)propylamine + CO2
-
-
-
?
S-adenosyl-L-methionine
S-adenosyl 3-(methylthio)propylamine + CO2
-
-
-
-
?
S-adenosyl-L-methionine
S-adenosyl 3-(methylthio)propylamine + CO2
-
-
-
?
S-adenosyl-L-methionine
S-adenosyl 3-(methylthio)propylamine + CO2
-
-
-
-
?
additional information
?
-
-
key rate-limiting enzyme located in the polyamine biosynthesis pathway. The SAMDC 5'-leader sequence participates in gene regulation at both the transcriptional and the posttranslational levels, which enables plants to sense their internal polyamine or environmental changes
-
-
?
additional information
?
-
key enzyme involved in polyamine biosynthetic pathway
-
-
?
additional information
?
-
key enzyme involved in polyamine biosynthetic pathway
-
-
?
additional information
?
-
key enzyme involved in polyamine biosynthetic pathway
-
-
?
additional information
?
-
key enzyme involved in polyamine biosynthetic pathway
-
-
?
additional information
?
-
-
adhesion-dependent expression of S-adenosylmethionine decarboxylase contributes to extracellular matrix-dependent differentiation of human salivary gland epithelial cells
-
-
?
additional information
?
-
-
key enzyme of polyamine biosynthetic pathway
-
-
?
additional information
?
-
-
S-adenosylmethionine decarboxylase is a key enzyme in the synthesis of polyamines essential for cell growth and proliferation. Its overexpression induces the transformation of murine fibroblasts in both sense and antisense orientations, yielding highly invasive tumors in nude mice. Thymosin B4 is a determinant of the transformed phenotype and invasiveness of S-adenosylmethionine decarboxylasetransfected fibroblasts
-
-
?
additional information
?
-
MdSAMDC2 is mainly involved in stress responses
-
-
?
additional information
?
-
-
MdSAMDC2 is mainly involved in stress responses
-
-
?
additional information
?
-
MdSAMDC1 is mainly involved in fruit development and cell growth
-
-
?
additional information
?
-
-
key rate-controlling enzyme in the synthesis of spermidine and spermine. Overexpression of AdoMetDC does not produce an overt cardiac phenotype, but there is an increased cardiac hypertrophy after beta-adrenergic stimulation, and crosses of alpha-myosin heavy chain/ADoMetDC mice with alpha-myosin heavy chain/ornithine decarboxylase mice are lethal at an early embryonic stage
-
-
?
additional information
?
-
-
S-adenosyl-L-methionine decarboxylase gene of cold-tolerant japonica cultivar Yukihikari and cold-susceptible indica variety TKM9 is differentially expressed under low temperature stress. Upon exposure to cold stress (5°C) the level of OsSAMDC transcripts in the cold-resistant Yukihihari genotype continues to increase for up to 72 h. There is no change in OsSAMDC transcription in the cold-susceptible indica cultivar TLM9 under the same conditions
-
-
?
additional information
?
-
-
synthesis of the triamine spermidine and the tetramine spermine is achieved by the sequential addition of aminopropyl moieties from decarboxylated S-adenosylmethionine, synthesized by the enzyme S-adenosylmethionine decarboxylase
-
-
?
additional information
?
-
-
critical regulatory enzyme of the polyamine biosynthetic pathway
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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(1E)-1-(9-bromo-3-phenanthryl)ethanone oxime
75% inhibition at 0.1 mM
(2E)-2-[(2E)-2-[(diaminomethyl)hydrazono]-1-methylethylidene]hydrazinecarboximidamide
-
i.e. MGBG, active site inhibitor
(2E)-2-[4-[amino(imino)methyl]-2,3-dihydro-1H-inden-1-ylidene]hydrazinecarboximidamide
(2R,3R,4R,5R)-2-([[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]methyl)-5-(6-amino-9H-purin-9-yl)-4-fluorotetrahydrofuran-3-ol
-
-
(2R,3R,4S,5R)-2-([[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]methyl)-5-(6-amino-9H-purin-9-yl)-4-fluorotetrahydrofuran-3-ol
-
-
(2R,3S,4R,5R)-2-([[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]methyl)-5-(6-amino-2-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diol
-
-
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt
(R)-alpha-methylspermine
-
-
(R,R)-alpha,omega-bismethylspermine
-
best suppressor of AdoMetDC activity
(S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
(S)-alpha-methylspermidine
-
-
1,1'-[(Methylethanediylidene)dinitrilo] bis(3-aminoguanidine)
-
-
1,3-di-9H-fluoren-2-ylthiourea
69% inhibition at 0.1 mM
1-(4-hydroxy-5-isopropyl-2-methylphenyl)-3-(1-naphthyl)urea
61% inhibition at 0.1 mM
2'-Chlorodeoxyadenosine
-
-
2'-[(9H-fluoren-2-ylamino)carbonyl]biphenyl-2-carboxylate
74% inhibition at 0.1 mM
2,2'-Dihydroxy-6,6'-dinaphthyl disulfide
-
-
2-amino-3-[(E)-(2-fluorophenyl)diazenyl]-4,5,6,7-tetrahydro-8H-cyclopenta[d]pyrazolo[1,5-a]pyrimidin-8-one
-
compound shows comparable inhibitory effects as methylglyoxal bis(guanylhydrazone)
2-[2-(diethylammonio)ethyl]-9-hydroxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazol-2-ium
67% inhibition at 0.1 mM
3-[(E)-[(2E)-[amino[(2E)-2-[3-[amino(imino)methyl]benzylidene]hydrazino]methylene]hydrazono]methyl]benzenecarboximidamide
-
i.e. CGP40215, active site inhibitor
4-Amidinoindan-1-(2'-amidino)hydrazone
4-amidinoindan-1-one-2'-amidinohydrazone
4-Bromo-3-hydroxybenzoyloxyamine dihydrogen phosphate
-
i.e. NSD-1055
4-Bromo-3-hydroxybenzyloxyamine
-
-
4-[(E)-2-(2-chlorophenyl)vinyl]quinolinium
67% inhibition at 0.1 mM
5'-([(Z)-4-Amino-2-butenyl]methylamino)-5'-deoxyadenosine
-
i.e. MDL 73811
5'-deoxy 5'-[(2-guanidinoethyl)methylamino]adenosine
less than 5% inhibition at 0.1 mM
5'-deoxy-5'-(2-methylaminoethylamino)adenosine
less than 5% inhibition at 0.1 mM
5'-deoxy-5'-(3-methylaminopropylamino)-8-phenyladenosine sulfate
less than 5% inhibition at 0.1 mM
5'-deoxy-5'-(dimethyl-sulfonio)adenosine
5'-deoxy-5'-(N,N-dimethylamino)-8-methyladenosine
-
5'-deoxy-5'-(N,N-dimethylamino)adenosine
-
5'-deoxy-5'-(N-dimethyl)amino-8-methyl adenosine
5'-deoxy-5'-(N-dimethyl)amino-8-methyladenosine
-
5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
5'-deoxy-5'-dimethylsulfonio-8-methyladenosine chloride
-
5'-deoxy-5'-dimethylsulfonioadenosine chloride
-
5'-deoxy-5'-dimethylthioadenosine
-
5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
5'-deoxy-5'-[(2-hydrazinocarbonylethyl)methylamino]-8-methyladenosine sulfate
-
5'-deoxy-5'-[(2-hydrazinocarbonylethyl)methylamino]-adenosine sulfate
-
5'-deoxy-5'-[(2-hydrazinoethyl)methylamino]adenosine
-
5'-deoxy-5'-[(2-hydroxyamidinoethyl)methylamino]adenosine
-
5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
5'-deoxy-5'-[(hydrazinocarbonylmethyl)methylamino]-8-methyladenosine
-
5'-deoxy-5'-[N-methyl-N-(3-hydrazino-propyl)amino]adenosine
5'-deoxy-5'-[N-methyl-N-(3-hydrazinopropyl)amino]adenosine
-
5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)-ethyl]amino]adenosine
5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)ethyl]amino]adenosine
-
5'-deoxy-8-(methylamino)-5'-(3-methylaminopropylamino)adenosine sulfate
less than 5% inhibition at 0.1 mM
5'-deoxy-8-methyl-5'-(2-methylaminoethylamino)adenosine
less than 5% inhibition at 0.1 mM
5'-dimethylthioadenosine sulfonium salt
-
-
5'-methylthioadenosine
-
-
5'-[(2-aminoethyl)methylamino]-5'-deoxy-8-methyladenosine
-
5'-[(2-aminoethyl)methylamino]-5'-deoxyadenosine
less than 5% inhibition at 0.1 mM
5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-(methylamino)adenosine sulfate
-
5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
-
5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-phenyladenosine sulfate
less than 5% inhibition at 0.1 mM
5'-[(2-aminooxyethyl)methylamino]-5'-deoxyadenosine
-
5'-[(2-carboxamidoethyl)methyamino]-5'-deoxy-8-ethyladenosine sulfate
-
5'-[(2-carboxamidoethyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
-
5'-[(2-carboxamidoethyl)methylamino]-5'-deoxyadenosine sulfate
-
5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-(methylamino)adenosine sulfate
-
5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-ethyladenosine sulfate
-
5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
-
5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-phenyladenosine sulfate
less than 5% inhibition at 0.1 mM
5'-[(3-aminopropyl)methylamino]-5'-deoxyadenosine sulfate
-
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-(methylamino)adenosine sulfate
-
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-ethyladenosine sulfate
-
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
-
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-oxoadenosine sulfate
-
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-phenyladenosine sulfate
less than 5% inhibition at 0.1 mM
5'-[(4-aminooxybutyl)methylamino]-5'-deoxyadenosine sulfate
-
5'-[(carboxamidomethyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
less than 5% inhibition at 0.1 mM
5'-[[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]-5'-deoxy-2-methyladenosine
-
-
5'-[[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]-5'-deoxy-8-ethyladenosine
-
-
5'-[[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]-5'-deoxy-8-methyladenosine
-
-
5'-[[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]-5'-deoxy-8-propyladenosine
-
-
5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine
5'-[[(Z)-4-aminobut-2-enyl](methylamino)]adenosine
5'-{[(Z)-4-Amino-2-butenyl]methylamino}-5'-deoxyadenosine
5,5'-dithiobis(2-nitrobenzoate)
-
-
8-methyl-5'-[[(Z)-4-aminobut-2-enyl]-(methylamino)]adenosine
9-amino-6-[(E)-(2,6-diaminopyridin-3-yl)diazenyl]-2-ethoxyacridinium
64% inhibition at 0.1 mM
9-hydroxy-5,11-dimethyl-2-(2-piperidinium-1-ylethyl)-6H-pyrido[4,3-b]carbazol-2-ium
69% inhibition at 0.1 mM
aminoguanidine
-
irreversible
Bis[[3-(aminoiminomethyl)phenyl]methylene]carbonimidic dihydrazide trihydrochloride
-
i.e. CGP 40215A
Canaline
-
at high concentrations
CGP 48664
-
specific inhibitor of AdoMetDC
CGP 48664A
-
i.e. 4-amidinoindan-1-one-20-amidinohydrazone, also known as SAM486A
CGP48664
-
non-competitive inhibition, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone
Di-N'''-Methylglyoxal bis(guanylhydrazone)
-
-
Di-N''-Methylglyoxal bis(guanylhydrazone)
-
-
Dimethylglyoxal bis(guanylhydrazone)
-
-
ethambutol
-
14% inhibition at 1 mM
ethylglyoxal bis(guanylhydrazone)
Glyoxal bis(guanylhydrazone)
-
-
Isonicotinic acid hydrazide
-
at high concentrations
methylglyoxal bis(guanylhydrazone)
methylglyoxal bis-(guanylhydrazone)
-
methylglyoxal-bis (guanylhydrazone)
methylglyoxal-bis(guanylhydrazone)
methylglyoxalbis(guanylhydrazone)
n-Butylglyoxal bis(guanylhydrazone)
-
-
N4-(3,5-dibromophenyl)-6-methylpyrimidine-2,4-diamine
more than 100fold selectivity for Trypanosoma brucei enzyme over human enzyme
N4-(3,5-dichloro-4-fluorophenyl)-6-methylpyrimidine-2,4-diamine
more than 100fold selectivity for Trypanosoma brucei enzyme over human enzyme
NaCl
-
enzyme from infected cells is unaffected up to 0.8 M, 50% inhibition of the enzyme from uninfected cells at 0.45 M
p-chloromercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
p-Hydroxymercuriphenylsulfonate
-
-
Pentane dialdehyde bis(guanylhydrazone)
Propane dialdehyde bis(guanylhydrazone)
S-(5'-Adenosyl)-methylthio-2-aminooxyethane
-
potent irreversible inhibitor
S-(5'-Deoxy-5'-adenosyl)methylthioethylhydroxylamine
S-Adenosyl-4-methylthiobutyric acid
-
-
S-Methyl-S-adenosyl-L-cysteine
-
-
S-methyladenosylhomocysteamine
-
strong
Salicylaldehyde
inactivation, substrate protects
(2E)-2-[4-[amino(imino)methyl]-2,3-dihydro-1H-inden-1-ylidene]hydrazinecarboximidamide
-
i.e. CGP48664A, SAM486A, active site inhibitor, in addition suppresses HIV-1 replication
(2E)-2-[4-[amino(imino)methyl]-2,3-dihydro-1H-inden-1-ylidene]hydrazinecarboximidamide
-
i.e. CGP 48664A, stimulation in the range of 0.1-10 microM, inhibition at higher comcentration. Binds to the putrescine binding site and to the active site
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt
-
competitive with respect to S-adenosylmethionine; i.e. decarboxylated S-adenosylmethionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt
-
-
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt
-
competitive with respect to S-adenosylmethionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt
-
irreversible
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt
-
-
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt
-
-
(S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
-
(S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
-
(S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
-
(S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
-
(S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
-
(S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
-
(S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
-
(S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
-
(S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
-
(S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
-
(S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
-
4-Amidinoindan-1-(2'-amidino)hydrazone
-
i.e. CGP 48664
4-Amidinoindan-1-(2'-amidino)hydrazone
-
-
4-Amidinoindan-1-(2'-amidino)hydrazone
-
i.e. CGP 48664
4-Amidinoindan-1-(2'-amidino)hydrazone
-
i.e. CGP 48664
4-amidinoindan-1-one-2'-amidinohydrazone
-
4-amidinoindan-1-one-2'-amidinohydrazone
-
4-amidinoindan-1-one-2'-amidinohydrazone
CGP48664A
4-amidinoindan-1-one-2'-amidinohydrazone
-
4-amidinoindan-1-one-2'-amidinohydrazone
-
4-amidinoindan-1-one-2'-amidinohydrazone
-
-
5'-deoxy-5'-(dimethyl-sulfonio)adenosine
-
5'-deoxy-5'-(dimethyl-sulfonio)adenosine
-
5'-deoxy-5'-(dimethyl-sulfonio)adenosine
-
5'-deoxy-5'-(dimethyl-sulfonio)adenosine
-
5'-deoxy-5'-(dimethyl-sulfonio)adenosine
-
-
5'-deoxy-5'-(N-dimethyl)amino-8-methyl adenosine
-
5'-deoxy-5'-(N-dimethyl)amino-8-methyl adenosine
-
5'-deoxy-5'-(N-dimethyl)amino-8-methyl adenosine
-
5'-deoxy-5'-(N-dimethyl)amino-8-methyl adenosine
-
5'-deoxy-5'-(N-dimethyl)amino-8-methyl adenosine
-
-
5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
-
5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
-
5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
-
5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
-
5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
-
5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
-
5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
-
5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
-
5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
-
5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
-
5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
-
5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
-
5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
-
5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
-
5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
-
5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
-
5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
-
5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
-
5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
-
5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
-
5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
-
5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
-
5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
-
5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
-
5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
-
5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
-
5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
irreversible
5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
-
5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
-
5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
-
5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
-
5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
-
5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
-
5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
-
5'-deoxy-5'-[N-methyl-N-(3-hydrazino-propyl)amino]adenosine
-
5'-deoxy-5'-[N-methyl-N-(3-hydrazino-propyl)amino]adenosine
-
5'-deoxy-5'-[N-methyl-N-(3-hydrazino-propyl)amino]adenosine
-
5'-deoxy-5'-[N-methyl-N-(3-hydrazino-propyl)amino]adenosine
-
5'-deoxy-5'-[N-methyl-N-(3-hydrazino-propyl)amino]adenosine
-
-
5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)-ethyl]amino]adenosine
-
5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)-ethyl]amino]adenosine
-
5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)-ethyl]amino]adenosine
-
5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)-ethyl]amino]adenosine
-
5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)-ethyl]amino]adenosine
-
-
5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine
-
MDL 73811
5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine
-
MDL 73811
5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine
-
MDL 73811
5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine
-
MDL 73811
5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine
-
MDL 73811
5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine
-
5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine
-
MDL 73811
5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine
-
MDL 73811
5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine
-
MDL 73811
5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine
-
MDL 73811
5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine
-
MDL 73811
5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine
-
MDL 73811
5'-[[(Z)-4-aminobut-2-enyl](methylamino)]adenosine
-
MDL-73811
5'-[[(Z)-4-aminobut-2-enyl](methylamino)]adenosine
-
MDL-73811
5'-{[(Z)-4-Amino-2-butenyl]methylamino}-5'-deoxyadenosine
-
irreversible; the inhibitor leads to transamination of the pyruvate prosthetic group
5'-{[(Z)-4-Amino-2-butenyl]methylamino}-5'-deoxyadenosine
-
irreversible
8-methyl-5'-[[(Z)-4-aminobut-2-enyl]-(methylamino)]adenosine
-
Genz-644131, potent inhibitor
8-methyl-5'-[[(Z)-4-aminobut-2-enyl]-(methylamino)]adenosine
-
Genz-644131, potent inhibitor
Berenil
-
-
Berenil
-
13% inhibition at 1 mM
BW-1
-
85% inhibition at 2 mM, in presence of 2 mM putrescine, degree of inhibition depends on actual putrescine abundance
BW-1
-
99% inhibition at 2 mM, in presence of 2 mM putrescine, degree of inhibition depends on actual putrescine abundance
Ca2+
-
-
Cd2+
-
0.5 mM CdCl2
CGP48664A
i.e. 4-amidinoindan-1-one-2'-amidinohydrazone
CGP48664A
i.e. 4-amidinoindan-1-one-2'-amidinohydrazone
CGP48664A
-
i.e. 4-amidinoindan-1-one-2'-amidinohydrazone
CGP48664A
i.e. 4-amidinoindan-1-one-2'-amidinohydrazone
CGP48664A
i.e. 4-amidinoindan-1-one-2'-amidinohydrazone
CGP48664A
-
i.e. 4-amidinoindan-1-one-2'-amidinohydrazone
Co2+
-
weak
EDTA
-
-
ethylglyoxal bis(guanylhydrazone)
-
-
ethylglyoxal bis(guanylhydrazone)
-
specific inhibitor of SAMDC
Genz-643990
-
-
Genz-644043
-
-
Genz-644053
-
-
Genz-644131
-
i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine
Genz-644131
-
i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine
Genz-644131
-
i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine
Genz-644131
-
i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine
Genz-644131
-
i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine
Genz-644131
-
i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine
Genz-644131
-
i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine
Genz-644131
-
i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine
Genz-644131
-
i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine
Genz-644131
-
i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine
Genz-644131
-
i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine
iodoacetic acid
-
-
iodoacetic acid
-
after treatment with iodoacetic acid at 37°C for 1 h, the activity of AdoMetDC in the absence of putrescine is almost completely inhibited
MDL 27695
-
44% inhibition at 2 mM, in presence of 2 mM putrescine
MDL 27695
-
86% inhibition at 2 mM, in presence of 2 mM putrescine
MDL 73811
-
irreversibel
MDL73811
7% residual activity at 0.001 mM
MDL73811
-
irreversible inhibitor
MDL73811
-
i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine, complete inhibition at 0.005 mM
MDL73811
-
irreversible inhibitor, i.e. 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine
MDL73811
-
irreversible inhibitor
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal bis(guanylhydrazone)
-
strong
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal bis(guanylhydrazone)
-
competitive
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal bis(guanylhydrazone)
-
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal bis(guanylhydrazone)
competitive inhibitor
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal bis(guanylhydrazone)
-
competitive, binds at a single site per enzyme heterodimer
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal bis(guanylhydrazone)
-
13% inhibition at 10 mM, 58% inhibition at 10 mM
methylglyoxal bis(guanylhydrazone)
-
and analogues
methylglyoxal bis(guanylhydrazone)
-
reversible
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal bis(guanylhydrazone)
-
competitive
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal bis(guanylhydrazone)
-
strong
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal bis(guanylhydrazone)
-
irreversible
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal bis(guanylhydrazone)
-
poor
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal bis(guanylhydrazone)
-
-
methylglyoxal-bis (guanylhydrazone)
-
competitive inhibitor
methylglyoxal-bis (guanylhydrazone)
-
-
methylglyoxal-bis(guanylhydrazone)
-
50% inhibition at 0.012 mM
methylglyoxal-bis(guanylhydrazone)
-
in the absence of phenanthrene, treatment with 2.0 mM methylglyoxal-bis(guanylhydrazone) inhibits SAMDC activity by 73%
methylglyoxalbis(guanylhydrazone)
-
methylglyoxalbis(guanylhydrazone)
-
methylglyoxalbis(guanylhydrazone)
-
methylglyoxalbis(guanylhydrazone)
-
methylglyoxalbis(guanylhydrazone)
-
-
NaBH4
-
-
NaCNBH3
-
inactivation in presence of adenosylmethionine and Mg2+, no inactivation in absence of substrate and Mg2+
NaCNBH3
-
inactivation in presence of substrate
NaCNBH3
-
in presence of substrate or product
NEM
-
-
Pentamidine
-
-
Pentamidine
-
irreversible
Pentane dialdehyde bis(guanylhydrazone)
-
-
Pentane dialdehyde bis(guanylhydrazone)
-
weak
phenylhydrazine
-
strong
PMW-2000-11-13-1
-
52% inhibition at 2 mM, in presence of 2 mM putrescine
PMW-2000-11-13-1
-
97% inhibition at 2 mM, in presence of 2 mM putrescine
Propane dialdehyde bis(guanylhydrazone)
-
-
Propane dialdehyde bis(guanylhydrazone)
-
weak
putrescine
-
-
RHW-17-69-75
-
45% inhibition at 2 mM, in presence of 2 mM putrescine
RHW-17-69-75
-
97% inhibition at 2 mM, in presence of 2 mM putrescine
S-(5'-Deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
irreversible
S-(5'-Deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
69% inhibition at 0.5 mM
S-adenosyl-L-methionine
-
substrate inactivation results in the conversion of the pyruvoyl group to an alanyl residue. The mechanism of inactivation involves the transamination of the nascent product to the pyruvoyl group, followed by the elimination of methylthioadenosine and the generation of a 2-propenal equivalent which can undergo a Michael addition to the enzyme
S-adenosyl-L-methionine
-
in presence of saturating concentrations of putrescine
SAM486A
-
previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone
SAM486A
-
previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone
SAM486A
-
previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone
SAM486A
-
previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone
SAM486A
-
previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone
SAM486A
-
also known as CGP48664
SAM486A
-
previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone
SAM486A
-
previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone
SAM486A
-
previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone
SAM486A
-
previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone
SAM486A
-
previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone
SAM486A
-
previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone
spermidine
-
-
spermine
-
-
spermine
-
inhibits the enzyme from liver from sham-operated rats, no effect on regenerating liver enzyme
Zn2+
-
-
additional information
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no inhibition by 1-aminooxy-3-aminopropane
-
additional information
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inhibitors with potent antitumor activity
-
additional information
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unaffected by divalent cations
-
additional information
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not inhibitory are: MgCl2, CaCl2, EDTA, putrescine at 10 mM each, or KCl at 50 mM
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additional information
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inhibitors with potent antitumor activity
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additional information
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inhibited by CGP 51467A, CGP 48009A, and CGP 62577A
-
additional information
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no inhibition by Tris
-
additional information
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inhibition of SAMDC by methylglyoxal-bis(guanylhydrazone), and hence reduced spermidine and spermine synthesis limits the ability of plants to recover following exposure to phenanthrene to a slightly greater extent than inhibition of arginine decarboxylase; inhibition of SAMDC results in much greater levels of oxidative damage than seen in plants treated with 0.5 microM phenanthrene; treatment of plants exposed to phenanthrene with DL-alpha-difluoromethylarginine does not result in any major changes to the trends in SAMDC activity observed in plants exposed to phenanthrene
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additional information
Thermostichus vulcanus
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the enzyme is almost insensitive to feedback inhibition at neutral pH
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additional information
identification of a inhibitor series based on a pyrimidineamine pharmacophore. The pyrimidineamines show selectivity for Trypanosoma brucei enzyme over the human enzyme, inhibit parasite growth in whole-cell assay, and have good predicted blood-brain barrier penetration
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1.2 - 104
3-[(E)-[(2E)-[amino[(2E)-2-[3-[amino(imino)methyl]benzylidene]hydrazino]methylene]hydrazono]methyl]benzenecarboximidamide
0.0006
5'-deoxy-5'-(N,N-dimethylamino)-8-methyladenosine
Homo sapiens
-
0.009
5'-deoxy-5'-(N,N-dimethylamino)adenosine
Homo sapiens
-
0.003
5'-deoxy-5'-dimethylsulfonio-8-methyladenosine chloride
Homo sapiens
-
0.015
5'-deoxy-5'-dimethylsulfonioadenosine chloride
Homo sapiens
-
0.00017
5'-deoxy-5'-[(2-hydrazinocarbonylethyl)methylamino]-8-methyladenosine
Homo sapiens
-
0.0015
5'-deoxy-5'-[(2-hydrazinocarbonylethyl)methylamino]-adenosine sulfate
Homo sapiens
-
0.157
5'-deoxy-5'-[(2-hydroxyamidinoethyl)methylamino]adenosine
Homo sapiens
-
0.031
5'-deoxy-5'-[(hydrazinocarbonylmethyl)methylamino]-8-methyladenosine
Homo sapiens
-
0.088
5'-[(2-aminoethyl)methylamino]-5'-deoxy-8-methyladenosine
Homo sapiens
-
0.000086
5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-(methylamino)adenosine sulfate
Homo sapiens
-
0.000007
5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
Homo sapiens
-
0.000055
5'-[(2-aminooxyethyl)methylamino]-5'-deoxyadenosine
Homo sapiens
-
0.004
5'-[(2-carboxamidoethyl)methyamino]-5'-deoxy-8-ethyladenosine sulfate
Homo sapiens
-
0.0004
5'-[(2-carboxamidoethyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
Homo sapiens
-
0.007
5'-[(2-carboxamidoethyl)methylamino]-5'-deoxyadenosine sulfate
Homo sapiens
-
0.44
5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-(methylamino)adenosine sulfate
Homo sapiens
-
0.42
5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-ethyladenosine sulfate
Homo sapiens
-
0.07
5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
Homo sapiens
-
0.5
5'-[(3-aminopropyl)methylamino]-5'-deoxyadenosine sulfate
Homo sapiens
-
0.000049
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-(methylamino)adenosine sulfate
Homo sapiens
-
0.000015
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-ethyladenosine sulfate
Homo sapiens
-
0.000005
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
Homo sapiens
-
0.000011
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-oxoadenosine sulfate
Homo sapiens
-
0.000018
5'-[(4-aminooxybutyl)methylamino]-5'-deoxyadenosine sulfate
Homo sapiens
-
0.001
MDL73811
Plasmodium falciparum
-
-
0.0019
N4-(3,5-dibromophenyl)-6-methylpyrimidine-2,4-diamine
Trypanosoma brucei brucei
pH 7.2, temperature not specified in the publication
0.0015
N4-(3,5-dichloro-4-fluorophenyl)-6-methylpyrimidine-2,4-diamine
Trypanosoma brucei brucei
pH 7.2, temperature not specified in the publication
1.2
3-[(E)-[(2E)-[amino[(2E)-2-[3-[amino(imino)methyl]benzylidene]hydrazino]methylene]hydrazono]methyl]benzenecarboximidamide
Trypanosoma cruzi
-
mutant F285H, presence of putrescine, 37°C, pH 8.0
3.2
3-[(E)-[(2E)-[amino[(2E)-2-[3-[amino(imino)methyl]benzylidene]hydrazino]methylene]hydrazono]methyl]benzenecarboximidamide
Trypanosoma cruzi
-
wild-type, presence of putrescine, 37°C, pH 8.0
13
3-[(E)-[(2E)-[amino[(2E)-2-[3-[amino(imino)methyl]benzylidene]hydrazino]methylene]hydrazono]methyl]benzenecarboximidamide
Trypanosoma cruzi
-
mutant D174V, absence of putrescine, 37°C, pH 8.0
14
3-[(E)-[(2E)-[amino[(2E)-2-[3-[amino(imino)methyl]benzylidene]hydrazino]methylene]hydrazono]methyl]benzenecarboximidamide
Trypanosoma cruzi
-
mutant D174V, presence of putrescine, 37°C, pH 8.0
26
3-[(E)-[(2E)-[amino[(2E)-2-[3-[amino(imino)methyl]benzylidene]hydrazino]methylene]hydrazono]methyl]benzenecarboximidamide
Trypanosoma cruzi
-
mutant F285H, absence of putrescine, 37°C, pH 8.0
32
3-[(E)-[(2E)-[amino[(2E)-2-[3-[amino(imino)methyl]benzylidene]hydrazino]methylene]hydrazono]methyl]benzenecarboximidamide
Trypanosoma cruzi
-
wild-type, absence of putrescine, 37°C, pH 8.0
96
3-[(E)-[(2E)-[amino[(2E)-2-[3-[amino(imino)methyl]benzylidene]hydrazino]methylene]hydrazono]methyl]benzenecarboximidamide
Trypanosoma cruzi
-
mutant S111R, absence of putrescine, 37°C, pH 8.0
104
3-[(E)-[(2E)-[amino[(2E)-2-[3-[amino(imino)methyl]benzylidene]hydrazino]methylene]hydrazono]methyl]benzenecarboximidamide
Trypanosoma cruzi
-
mutant S111R, presence of putrescine, 37°C, pH 8.0
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115000
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meniscus depletion method
14600
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2 * 32500, alpha, + 2 * 14600, beta, SDS-PAGE
15000
-
estimated from amino acid sequence
16602
2 * 16602, electrospray ionization mass spectrometry
16680
2 * 16680, calculated from sequence
19000
-
4 * 19000, alpha, + 4 * 14000, beta, (alphabeta)4 structure, SDS-PAGE
30600
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x * 39600, proenzyme, x * 30600, alpha, + x * 8900, beta, SDS-PAGE
33000
His10-tagged enzyme, gel filtration
37000
-
estimated from amino acid sequence
38000
-
estimated from amino acid sequence
39000
-
estimated from amino acid sequence
39086
x * 39086, calculated from amino acid sequence
39600
-
x * 39600, proenzyme, x * 30600, alpha, + x * 8900, beta, SDS-PAGE
40000
-
estimated from amino acid sequence
40400
x * 40400, calculated from sequence
40600
x * 40600, calculation from nucleotide sequence
41000
-
2 * 41000, SDS-PAGE
42000
-
estimated from amino acid sequence
47000
-
uterus, gel filtration
6000
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2 * 6000, alpha, + 2 * 8000, beta, SDS-PAGE, 2 * 6793 * 2 * 6990, MALDI-TOF
6793
-
2 * 6000, alpha, + 2 * 8000, beta, SDS-PAGE, 2 * 6793 * 2 * 6990, MALDI-TOF
6990
-
2 * 6000, alpha, + 2 * 8000, beta, SDS-PAGE, 2 * 6793 * 2 * 6990, MALDI-TOF
74000
-
sucrose density gradient centrifugation
8000
-
2 * 6000, alpha, + 2 * 8000, beta, SDS-PAGE, 2 * 6793 * 2 * 6990, MALDI-TOF
8900
-
x * 39600, proenzyme, x * 30600, alpha, + x * 8900, beta, SDS-PAGE
9000
-
1 * 70000 + 1 * 9000, recombinant enzyme, SDS-PAGE
additional information
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-
10000
2 * 32000, alpha, + 2 * 10000, beta, SDS-PAGE
10000
2 * 32000, alpha, + 2 * 10000, beta, SDS-PAGE, subunits derived from autocatalytically cleaved protein
14000
-
estimated from amino acid sequence
14000
-
estimated from amino acid sequence
14000
-
4 * 19000, alpha, + 4 * 14000, beta, (alphabeta)4 structure, SDS-PAGE
30000
-
PAGE
30000
-
estimated from amino acid sequence
32000
-
estimated from amino acid sequence
32000
-
2 * 32000, SDS-PAGE
32000
-
x * 32000, SDS-PAGE
32000
-
1 * 32000, SDS-PAGE
32000
2 * 32000, alpha, + 2 * 10000, beta, SDS-PAGE
32000
2 * 32000, alpha, + 2 * 10000, beta, SDS-PAGE, subunits derived from autocatalytically cleaved protein
32000
-
x * 32000, SDS-PAGE of recombinant alpha subunit, including His-tag
32500
-
2 * 32500, SDS-PAGE
32500
-
2 * 32500, alpha, + 2 * 14600, beta, SDS-PAGE
35000
-
gel filtration
35000
-
2 * 35000, SDS-PAGE
40500
x * 40500, calculated from sequence
40500
x * 40500, calculation from nucleotide sequence
44000
-
liver, gel filtration
44000
-
estimated from amino acid sequence
46000
-
estimated from amino acid sequence
46000
-
x * 46000, including His6-tag of recombinant protein, SDS-PAGE
52000
-
liver, sucrose density gradient centrifugation
52000
-
prostate, gel filtration
68000
-
gel filtration
70000
gel filtration
70000
-
1 * 70000 + 1 * 9000, recombinant enzyme, SDS-PAGE
88000
-
gel filtration
88000
-
non-denaturing PAGE
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C83A
10% residual enzymic activity
D190N
-
reduced activation by putrescine, spermidine or spermine
E194Q
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strongly enhanced basic activity, little activation by putrescine, spermidine or spermine
E274Q
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slightly enhanced basic activity, reduced activation by putrescine, spermidine or spermine
E33Q
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drastically reduced activation by putrescine, no activation by spermidine or spermine, no complete processing of pro-protein
K95A
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no activation, no complete processing of pro-protein
R91A
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drastically reduced activation by putrescine, spermidine or spermine, no complete processing of pro-protein
S128A
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drastically reduced activation by putrescine, spermidine or spermine
S83A
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no activation, no processing of pro-protein
T192A
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slightly enhanced basic activity, reduced activation by putrescine, spermidine or spermine
H243A
the mutation traps the enzyme in the ester form
S68A
themutant lacks the hydroxyl group necessary for processing and traps the enzyme in a form similar to the proenzyme
C505S
-
the expression level and specific activity of the mutant is unchanged compared to the wild type enzyme. The mutant protein occurs mainly as a monomer
K15A
-
mutant enzyme is 50% less active compared to wild-type
K215A
-
mutant enzyme is 50% less active compared to wild-type
R11L
-
mutant enzyme is almost inactive
M37F
the mutant shows reduced catalytic efficiency compared to the wild type enzyme
M37W
the mutant shows reduced catalytic efficiency compared to the wild type enzyme
M37Y
the mutant shows reduced catalytic efficiency compared to the wild type enzyme
C83A
-
mutant proenzyme is cleaved more rapidly than the wild-type enzyme
H68A
-
mutant proenzyme is cleaved much more slowly than the wild-type enzyme
S55A
-
mutant proenzyme is cleaved more rapidly than the wild-type enzyme
S63A
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the mutation traps the enzyme in the proenzyme form
C82A
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drastically reduced single turnover rate, no solvent isotope effect, C82 may function as a general aci/base in catalysis
D174A
-
protein is fully processed, but no putrescine binding or activation
D174V
-
residue in putrescine binding site, no activation by putrescine
E15A
-
protein is fully processed, no influence on putrescine binding
E256A
-
protein is fully processed, no influence on putrescine binding
F285H
-
residue in putrescine binding site, enhanced catalytic activity
I80K/S178E
-
protein is fully processed, no influence on putrescine binding
R13L
-
no processing of enzyme
S111R
-
residue in putrescine binding site, reduced catalytic activity
C230A
minimal effect on caqtalytic activity
C230A
minimal effect on catalytic activity, thermally unstable, higher alpha-helix content and lower coiled-coil content than wild type
C50A
minimal effect on caqtalytic activity
C50A
minimal effect on catalytic activity, thermally unstable, higher alpha-helix content and lower coiled-coil content than wild type
K81A
60% residual enzymic activity, altered substrate specificity
K81A
6fold higher substrate specificity with lysine, higher pH-optimum
C82A
-
reduced enzymic activity, no inhibition by iodoacetic acid
C82A
the mutant shows decreased kcat compared to the wild type enzyme
additional information
enzyme deletion results in bushy and dwarf mutant plants, with enlarged vascular systems in inflorescences, roots and petioles, and an altered homeostasis of polyamines. The double mutant of bud2 and samdc1, another S-adenosylmethionine decarboxylase, is embryo lethal
additional information
-
overexpression of enzyme in tobacco results in accumulation of polyamines in transgenic plants. Transgenic tobacco does not show any difference in organ phenotype compared to wild-type. The number and weight of seeds increases, and net photosynthetic rate also increases. Abiotic stress-induced damage is attenuated in transgenic plants
additional information
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adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase in lung cancer cell line A-549. Antisense enzyme expression inhibits tumor cell growth through blocking the polyamine synthesis pathway. Tumor cells are arrested at G1 phase and invasivness is reduced
additional information
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adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase significantly induces G1 arrest, decreases levels of cyclin D1 protein and mRNA and suppresses the promoter activity. Antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase also inhibit nuclear translocation of beta-catenin
additional information
suppression of enzyme expression in HL-60 cells by RNAi results in overproduction of reactive oxygen species, leading to growth defect and partial cell death. Reactive oxygen species is caused by a decrease of the total glutathione and the ratio of reduced to oxidized glutathione, and by an increase of the intracellular iron uptake
additional information
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targeted disruption of enzyme gene, heterozygous animals were viable, normal and fertile, homozygous embryos died early in embryonic development, homozygous blastocysts at E3.5 arrested cell proliferation which was rescued by addition of spermidine
additional information
deletion of parasite-specific regions, analysis of influence on catalytic activities and domain interactions, co-incubation of monofunctional heterotetrameric S-adenosyl-L-methionine decarboxylase domain with monofunctional, homodimeric ornithine decarboxylase domain produces an active hybrid complex of 330,000 Da
additional information
-
deletion of parasite-specific regions, analysis of influence on catalytic activities and domain interactions, co-incubation of monofunctional heterotetrameric S-adenosyl-L-methionine decarboxylase domain with monofunctional, homodimeric ornithine decarboxylase domain produces an active hybrid complex of 330,000 Da
additional information
modeling and activity of a chimeric arginine decarboxylase/S-adenosylmethionine decarboxylase proteins. A chimeric protein containing the beta subunit of arginine decarboxylase (SSO0536) and the alpha subunit of S-adenosylmethionine decarboxylase (SSO0585) has arginine decarboxylase activity and no S-adenosylmethionine decarboxylase activity, implicating residues responsible for substrate specificity in the beta subunit
additional information
-
modeling and activity of a chimeric arginine decarboxylase/S-adenosylmethionine decarboxylase proteins. A chimeric protein containing the beta subunit of arginine decarboxylase (SSO0536) and the alpha subunit of S-adenosylmethionine decarboxylase (SSO0585) has arginine decarboxylase activity and no S-adenosylmethionine decarboxylase activity, implicating residues responsible for substrate specificity in the beta subunit
additional information
-
modeling and activity of a chimeric arginine decarboxylase/S-adenosylmethionine decarboxylase proteins. A chimeric protein containing the beta subunit of arginine decarboxylase (SSO0536) and the alpha subunit of S-adenosylmethionine decarboxylase (SSO0585) has arginine decarboxylase activity and no S-adenosylmethionine decarboxylase activity, implicating residues responsible for substrate specificity in the beta subunit
-
additional information
expression without the two upstream ORFs results in 50fold increase in activity compared to expression of full length DNA
additional information
-
expression without the two upstream ORFs results in 50fold increase in activity compared to expression of full length DNA
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