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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-(3-indolyl)glycerol-3-phosphate + CO2 + H2O
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
indoleglycerol phosphate + CO2 + H2O
-
-
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate + ?
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
additional information
?
-
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-(3-indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-(3-indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
-
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
-
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
-
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
the enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
elucidation of the kinetic reaction mechanism, importance of flexible active loops for substrate binding and catalysis by the enzyme, product release is the rate-limiting step of the overall reaction
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
tryptophan biosynthetic enzyme
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
Lys53 acts as the general acid in the dehydration step of the reaction
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
the enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
elucidation of the kinetic reaction mechanism, importance of flexible active loops for substrate binding and catalysis by the enzyme, product release is the rate-limiting step of the overall reaction
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
Lys53 acts as the general acid in the dehydration step of the reaction
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
Enterobacter liquefaciens
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
ir
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
ir
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
regulation of enzyme activity
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
Enterobacter liquefaciens
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
regulation of enzyme activity
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate + ?
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate + ?
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate + ?
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate + ?
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
-
-
?
additional information
?
-
a different degree of loop mobility correlates with different rate-limiting steps in the catalytic mechanism. Both the application of activating mutations and temperature increase lead to a net increase in the catalytic turnover number due to acceleration of the product release rate relative to the chemical transformation steps
-
-
?
additional information
?
-
-
a different degree of loop mobility correlates with different rate-limiting steps in the catalytic mechanism. Both the application of activating mutations and temperature increase lead to a net increase in the catalytic turnover number due to acceleration of the product release rate relative to the chemical transformation steps
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-(3-indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
-
-
ir
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
-
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
-
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
the enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
tryptophan biosynthetic enzyme
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
the enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
-
-
?
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
regulation of enzyme activity
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
Enterobacter liquefaciens
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
regulation of enzyme activity
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
-
-
-
?
1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
?
-
enzyme is involved in tryptophan biosynthesis
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.000013 - 0.09
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
0.000006 - 21.67
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
0.000013
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 75°C, mutant enzyme E51Q
0.000023
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 37°C, mutant enzyme R54A/N90Q
0.000036
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 25°C, mutant enzyme N90A
0.000044
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 75°C, wild-type enzyme
0.000044
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 75°C, wild-type enzyme
0.000045
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 25°C, mutant enzyme R18C labeled with the fluorescent dye Alexa Fluor 555
0.000046
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 25°C, mutant enzyme D61C labeled with the fluorescent dye PyMPO
0.00005
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 25°C, mutant enzyme R18C labeled with the fluorescent dye PyMPO
0.000051
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 25°C, wild-type enzyme
0.000074
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 25°C, wild-type enzyme
0.000074
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 37°C, mutant enzyme N90A
0.000074
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 75°C, mutant enzyme R54A
0.000079
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 75°C, mutant enzyme N90A
0.000085
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
wild-type, pH 7.5, 25°C
0.000088
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 27°C, wild-type enzyme
0.000095
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 37°C, mutant enzyme R54A
0.000105
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
wild-type, pH 7.5, 60°C
0.000107
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 75°C, mutant enzyme R54A/N90Q
0.000109
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 25°C, mutant enzyme D61C labeled with the fluorescent dye Alexa Fluor 555
0.000117
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 75°C, mutant enzyme N90Q
0.000132
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 37°C, mutant enzyme N90Q
0.000145
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 25°C, mutant enzyme R54A
0.000386
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 75°C, mutant enzyme E210Q
0.00106
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 75°C, mutant enzyme R182A
0.0012
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 75°C, mutant enzyme F89A
0.0013
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
mutant F246S, pH 7.5, 25°C
0.0016
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
at pH 7.5 and 37°C
0.00244
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 75°C, mutant enzyme K53R
0.0029
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
mutant M237T, pH 7.5, 25°C
0.0034
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
mutant L236Q, pH 7.5, 25°C
0.0113
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
at 37°C and pH 8.0
0.0217
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
mutant G212E, pH 7.5, 25°C
0.045
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 25°C
0.055
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
25°C, pH 7.5
0.09
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.5, 25°C
0.000006
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 25°C
0.000014
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 45°C
0.000025
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
wild-type, pH 7.5, 25°C
0.00004
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 25°C, wild-type enzyme
0.000045
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
wild-type enzyme
0.000047
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
genetically engineered monofunctional enzyme form IGPS[1-259]
0.00005
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 37°C, wild-type enzyme
0.00005
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 37°C, mutant enzyme P2S
0.00005
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 60°C, wild-type enzyme
0.000053
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 60°C
0.00009
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
wild-type, pH 7.5, 25°C
0.000123
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 80°C
0.00021
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
mutant Leu5Val
0.00034
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
wild-type enzyme
0.0004
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 37°C, mutant enzyme F246S
0.00042
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
bifunctional enzyme
0.00042
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 25°C, mutant enzyme P2S/F246S
0.00069
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
N-terminal deletion mutant lacking 25 amino acids, pH 7.5, 25°C
0.0012
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
wild-type enzyme
0.0026
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
at 60°C
0.005
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
-
0.0056
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 37°C, mutant enzyme G212E
0.0058
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
-
0.0099
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
truncated mutant
0.0099
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
N-terminal deletion mutant lacking 26 amino acids, pH 7.5, 25°C
0.0109
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 25°C, mutant enzyme P2S/G212E
0.013
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
genetically engineered monofunctional enzyme form IGPS[1-252FAG]
0.54
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
mutant Lys55Ser
1.13
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
increased Km value in the presence of ATB107
1.13
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
increased Km value in the presence of ATB107
1.19
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
H170A site directed mutagenesis
1.19
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
H170A site directed mutagenesis
1.42
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
L193A site directed mutagenesis
1.42
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
L193A site directed mutagenesis
1.53
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
S64A site directed mutagenesis
1.53
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
S64A site directed mutagenesis
1.53
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
V169A site directed mutagenesis
1.53
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
V169A site directed mutagenesis
1.81
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
L196A site directed mutagenesis
1.81
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
L196A site directed mutagenesis
2.49
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
P63A site directed mutagenesis
2.49
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
P63A site directed mutagenesis
2.57
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
N192A site directed mutagenesis
2.57
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
N192A site directed mutagenesis
6.63
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
R191A site directed mutagenesis
6.63
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
R191A site directed mutagenesis
20.34
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
N189A site directed mutagenesis
20.34
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
N189A site directed mutagenesis
21.67
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
E168A site directed mutagenesis
21.67
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
E168A site directed mutagenesis
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.001 - 11.1
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
0.025 - 7.2
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
0.001
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 75°C, mutant enzyme K53Q
0.007
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 75°C, mutant enzyme E51Q
0.033
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 25°C
0.038
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 25°C, mutant enzyme D61C labeled with the fluorescent dye PyMPO
0.04
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 25°C, mutant enzyme R18C labeled with the fluorescent dye Alexa Fluor 555
0.04
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 25°C, mutant enzyme N90A
0.042
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 25°C, mutant enzyme R18C labeled with the fluorescent dye PyMPO
0.06
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 75°C, mutant enzyme F89A
0.06
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 75°C, mutant enzyme K53R
0.062
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 25°C, wild-type enzyme
0.065
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 25°C, mutant enzyme D61C labeled with the fluorescent dye Alexa Fluor 555
0.11
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
wild-type, pH 7.5, 25°C
0.16
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 25°C, wild-type enzyme
0.16
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
25°C, pH 7.5
0.16
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 25°C, mutant enzyme R54A
0.16
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
mutant G212E, pH 7.5, 25°C
0.17
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 37°C, mutant enzyme N90A
0.19
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 37°C, mutant enzyme R54A/N90Q
0.2
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
mutant L236Q, pH 7.5, 25°C
0.23
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
mutant M237T, pH 7.5, 25°C
0.3
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 37°C, mutant enzyme N90Q
0.32
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
mutant F246S, pH 7.5, 25°C
0.35
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 37°C, mutant enzyme R54A
0.41
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 75°C, mutant enzyme R182A
0.42
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 37°C, wild-type enzyme
0.51
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 75°C, mutant enzyme R54A/N90Q
0.55
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 75°C, mutant enzyme N90A
0.67
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 75°C, wild-type enzyme
0.67
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 75°C, wild-type enzyme
0.89
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 75°C, mutant enzyme N90Q
0.97
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 75°C, mutant enzyme E210Q
1.2
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.5, 25°C
1.2
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 75°C, mutant enzyme R54A
2.1
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
wild-type, pH 7.5, 60°C
4.1
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
at pH 7.5 and 25°C
9.3
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
at pH 7.5 and 37°C
11.1
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
at 37°C and pH 8.0
0.025
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
wild-type, pH 7.5, 25°C
0.028
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
N-terminal deletion mutant lacking 26 amino acids, pH 7.5, 25°C
0.03
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 25°C, wild-type enzyme
0.033
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
wild-type enzyme
0.041
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
truncated mutant
0.06
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
N-terminal deletion mutant lacking 25 amino acids, pH 7.5, 25°C
0.095
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
wild-type, pH 7.5, 25°C
0.12
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
mutant enzyme Lys55Ser
0.15
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 37°C, wild-type enzyme
0.16
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 37°C, mutant enzyme P2S
0.27
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 25°C, mutant enzyme P2S/F246S
0.35
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 37°C, mutant enzyme F246S
0.36
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 37°C, mutant enzyme G212E
0.57
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 25°C, mutant enzyme P2S/G212E
0.98
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 60°C, wild-type enzyme
2
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
mutant Leu5Val
2.2
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
wild-type enzyme
3.15
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
at 60°C
3.2
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
genetically engineered monofunctional enzyme form IGPS[1-259]
3.6
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
bifunctional enzyme
4.3
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
genetically engineered monofunctional enzyme form IGPS[1-252FAG]
7.2
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
wild-type enzyme
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1.36 - 20000
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
100 - 14200
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
1.36
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 25°C
2.9
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
25°C, pH 7.5
10
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
mutant G212E, pH 7.5, 25°C
13.3
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.5, 25°C
30
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 75°C, mutant enzyme K53R
50
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 75°C, mutant enzyme F89A
60
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
mutant L236Q, pH 7.5, 25°C
80
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
mutant M237T, pH 7.5, 25°C
240
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
mutant F246S, pH 7.5, 25°C
380
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 75°C, mutant enzyme R182A
540
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 75°C, mutant enzyme E51Q
596
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 25°C, mutant enzyme D61C labeled with the fluorescent dye Alexa Fluor 555
826
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 25°C, mutant enzyme D61C labeled with the fluorescent dye PyMPO
840
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 25°C, mutant enzyme R18C labeled with the fluorescent dye PyMPO
888
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 25°C, mutant enzyme R18C labeled with the fluorescent dye Alexa Fluor 555
980
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
at 37°C and pH 8.0
1000
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 25°C, mutant enzyme N90A
1180
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
wild-type, pH 7.5, 25°C
1215
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 25°C, wild-type enzyme
2200
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 25°C, mutant enzyme R54A
2200
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 25°C, wild-type enzyme
2300
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 37°C, mutant enzyme N90A
2300
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 37°C, mutant enzyme N90Q
2500
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 75°C, mutant enzyme E210Q
3700
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 37°C, mutant enzyme R54A
4800
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 37°C, wild-type enzyme
4800
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 75°C, mutant enzyme R54A/N90Q
5700
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
at pH 7.5 and 37°C
7000
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 75°C, mutant enzyme N90A
7600
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 75°C, mutant enzyme N90Q
8200
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 37°C, mutant enzyme R54A/N90Q
15000
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 75°C, wild-type enzyme
15230
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
pH 7.5, 75°C, wild-type enzyme
16000
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
pH 7.0, 75°C, mutant enzyme R54A
20000
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
wild-type, pH 7.5, 60°C
100
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 25°C, mutant enzyme P2S/G212E
100
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 37°C, mutant enzyme G212E
600
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 25°C, mutant enzyme P2S/F246S
750
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 25°C, wild-type enzyme
900
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 37°C, mutant enzyme F246S
3000
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 37°C, wild-type enzyme
3200
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 37°C, mutant enzyme P2S
14200
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
pH 7.5, 60°C, wild-type enzyme
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L55S
-
Lys55Ser with 60fold decrease in turnover-number and 450fold increase in Km-value
L5V
-
Leu5Val without effect on turnover-number and Km
E168A
site directed mutagenesis
H170A
site directed mutagenesis
L193A
site directed mutagenesis
L196A
site directed mutagenesis
N189A
site directed mutagenesis
N192A
site directed mutagenesis
P63A
site directed mutagenesis
R191A
site directed mutagenesis
S64A
site directed mutagenesis
V169A
site directed mutagenesis
E168A
site directed mutagenesis
H170A
site directed mutagenesis
L193A
site directed mutagenesis
L196A
site directed mutagenesis
N189A
site directed mutagenesis
N192A
site directed mutagenesis
P63A
site directed mutagenesis
R191A
site directed mutagenesis
S64A
site directed mutagenesis
V169A
site directed mutagenesis
E168A
-
site directed mutagenesis
-
L196A
-
site directed mutagenesis
-
R191A
-
site directed mutagenesis
-
S64A
-
site directed mutagenesis
-
D61C
kcat/Km for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate is about 1.5fold lower than the wild-type value
E210Q
kcat/Km for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate is 6fold lower than wild-type value
E51Q
kcat/Km for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate is 28fold lower than wild-type value
F89A
-
approximately 24fold increase in the KM-value, eleven-fold decrease in the maximum turnover rate
K53Q
low activity, kcat is 570fold lower than wild-type value
K53R
kcat/Km for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate is 500fold lower than wild-type value
L236Q
mutation destabilizes helix alpha8'
N90A
-
loss of the descending limb in the pH rate profile, 5-fold decrease in kcat at 25°C, but at higher temperatures (i.e. 75°C), the kinetic parameters for the N90A mutant enzyme closer to wild-type enzyme. Mutant enzyme has substantially reduced solvent deuterium kinetic isotope effects compared to wild-type enzyme at 75°C. 2fold decrease in the rate of thermal inactivation at 90°C as compared to wild-type enzyme
N90Q
-
the steady-state kinetics for the mutant enzyme are substantially decreased compared to wild-type enzyme at lower temperatures, but kcat of the N90Q variant approaches that of wild-type enzyme at higher temperatures. The solvent deuterium kinetic isotope effects on kcat is also substantially reduced compared to wild-type enzyme. 2fold decrease in the rate of thermal inactivation at 90°C
P2S
-
slight increase in kcat/Km (substrate: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate). Mutant enzyme is about as thermostable as wild-type enzyme
P2S/F246S
-
about 2fold increase in turnover-number, 8fold increase in KM-value, decrease in kcat/Km
P2S/G212E
-
about 4fold increase in turnover-number,200fold increase in Km-valuer, decrease in kcat/Km
R182A
kcat/Km for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate is 39fold lower than wild-type value
R18C
kcat/Km for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate is about 1.5fold lower than the wild-type value
R54A
-
mutation does not result in any substantial change to the steady-state kinetic parameters at any of the temperatures assayed (25°C, 37°C, 75°C). At 75°C, the mutant enzyme shows a small increase to kcat (about 1.8 fold) compared to wild-type enzyme. Mutant enzyme has substantially reduced solvent deuterium kinetic isotope effects compared to wild-type enzyme at 75°C. Thermal inactivation constant at 90°C is similar to wild-typ enzyme
R54A/N90A
-
the R54A/N90A double substitution are not additive with the effects of the R54A and N90A single substitutions suggesting some type of thermodynamic coupling between these residues
R64A/D65A
mutation disrupts interactions on the C-terminal side of the beta1alpha1 loop and decreases catalytic efficiency, slows down the dehydration step and quenches loop dynamics
R64A/D65A/N90A
mutation leads to new micros-ms timescale loop dynamics and makes the ring-closure step rate-determining once again
R64A/D65A
-
mutation disrupts interactions on the C-terminal side of the beta1alpha1 loop and decreases catalytic efficiency, slows down the dehydration step and quenches loop dynamics
-
R64A/D65A/N90A
-
mutation leads to new micros-ms timescale loop dynamics and makes the ring-closure step rate-determining once again
-
D61C
-
kcat/Km for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate is about 1.5fold lower than the wild-type value
-
E210Q
-
kcat/Km for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate is 6fold lower than wild-type value
-
E51Q
-
kcat/Km for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate is 28fold lower than wild-type value
-
K53Q
-
low activity, kcat is 570fold lower than wild-type value
-
K53R
-
kcat/Km for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate is 500fold lower than wild-type value
-
R182A
-
kcat/Km for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate is 39fold lower than wild-type value
-
R18C
-
kcat/Km for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate is about 1.5fold lower than the wild-type value
-
D184A
-
no alteration of native structure, very little difference in Km, turnover rate compared to wild type, but less thermal stability
R241A
-
no alteration of native structure, very little difference in Km, turnover rate compared to wild type, but less thermal stability
F246S
-
about 2fold increase in turnover-number, 8fold increase in KM-value, decrease in kcat/Km
F246S
mutation at C-terminus, increases flexibility
G212E
-
about 2fold increase in turnover-number, 100fold increase Km-value, decrease in kcat/Km. Mutant enzyme is about as thermostable as wild-type enzyme
G212E
mutation interferes with phosphate binding
M237T
-
kcat/Km of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate is fold than wild-type value
M237T
mutation destabilizes helix alpha8'
additional information
-
-
additional information
-
engineering of a monofunctional enzyme by separating the domains on the gene level and expression as monofunctional enzymes
additional information
site directed mutagenesis studies indicate that ATB107 may inhibit IGPS activity by reducing the binding affinity for substrate of residues Glu168 and Asn189
additional information
-
site directed mutagenesis studies indicate that ATB107 may inhibit IGPS activity by reducing the binding affinity for substrate of residues Glu168 and Asn189
additional information
site directed mutagenesis studies indicate that ATB107 may inhibit IGPS activity by reducing the binding affinity for substrate of residues Glu168 and Asn189
additional information
-
site directed mutagenesis studies indicate that ATB107 may inhibit IGPS activity by reducing the binding affinity for substrate of residues Glu168 and Asn189
-
additional information
-
mutant enzyme with deletion of 8 terminal residues is soluble and has the same turnover number as the wild-type protein but a 220-fold greater Km-value
additional information
deletion of N-terminal 26 amino acids, unchanged oligomerzation states and turnover numbers, increase in Km-value for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate, decrease in resistance towards unfolding induced by heat and guanidinium chloride
additional information
-
deletion of N-terminal 26 amino acids, unchanged oligomerzation states and turnover numbers, increase in Km-value for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate, decrease in resistance towards unfolding induced by heat and guanidinium chloride
additional information
deletion of N-terminal 25 amino acids, unchanged oligomerzation states and turnover numbers, increase in Km-value for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate, decrease in resistance towards unfolding induced by heat and guanidinium chloride
additional information
-
deletion of N-terminal 25 amino acids, unchanged oligomerzation states and turnover numbers, increase in Km-value for 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate, decrease in resistance towards unfolding induced by heat and guanidinium chloride
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-
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Saccharolobus solfataricus
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1054-1064
2011
Thermus thermophilus (P84126), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (P84126)
brenda
Zaccardi, M.J.; Mannweiler, O.; Boehr, D.D.
Differences in the catalytic mechanisms of mesophilic and thermophilic indole-3-glycerol phosphate synthase enzymes at their adaptive temperatures
Biochem. Biophys. Res. Commun.
418
324-329
2012
Escherichia coli
brenda
Gerth, M.L.; Nigon, L.V.; Patrick, W.M.
Characterization of the indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa PAO1
Protein J.
31
359-365
2012
Pseudomonas aeruginosa
brenda
Schlee, S.; Klein, T.; Schumacher, M.; Nazet, J.; Merkl, R.; Steinhoff, H.J.; Sterner, R.
Relationship of Catalysis and Active Site Loop Dynamics in the (betaalpha)8 barrel enzyme indole-3-glycerol phosphate synthase
Biochemistry
57
3265-3277
2018
Saccharolobus solfataricus (Q06121), Saccharolobus solfataricus
brenda
O'Rourke, K.; Jelowicki, A.; Boehr, D.
Controlling active site loop dynamics in the (beta/alpha)8 barrel enzyme indole-3-glycerol phosphate synthase
Catalysts
6
129
2016
Saccharolobus solfataricus (Q06121), Saccharolobus solfataricus DSM 1617 (Q06121)
-
brenda