Reference on EC 3.8.1.2 - (S)-2-haloacid dehalogenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Motosugi, K; Esahi, N.; Soda, K.
Enzymatic preparation of D- and L-lactic acid from racemic 2-chloropropionic acid
Biotechnol. Bioeng.
26
805-806
1984
Pseudomonas sp., Pseudomonas putida, Pseudomonas sp. 113
Liu, J.Q.; Kurihara, T.; Hasan, A.K.M.Q.; Nardi-Dei, V.; Koshikawa, H.; Esaki, N.; Soda, K.
Purification and characterization of thermostable and nonthermostable 2-haloacid dehalogenases with different stereospecificities from Pseudomonas sp. strain YL
Appl. Environ. Microbiol.
60
2389-2393
1994
Pseudomonas sp.
Leigh, J.A.; Skinner, A.J.; Cooper, R.A.
Partial purification, stereospecificity and stoichiometry of three dehalogenases from a Rhizobium species
FEMS Microbiol. Lett.
49
353-356
1988
Rhizobium sp.
-
Kurihara, T.; Esaki, N.; Soda, K.
Bacterial 2-haloacid dehalogenases: structures and reaction mechanisms
J. Mol. Catal. B
10
57-65
2000
Pseudomonas sp.
-
Hasan, A.K.M.Q.; Takada, H.; Koshikawa, H.; Liu, J.Q.; Kurihara, T.; Esaki, N.; Soda, K.
Two kinds of 2-halo acid dehalogeases fromm Pseudomonas sp. YL induced by 2-chloroacrylates and 2-chloropropionate
Biosci. Biotechnol. Biochem.
58
1599-1602
1994
Pseudomonas sp.
-
Klages, M.; Krauss, S.; Lingens, F.
2-Haloacid dehalogenase from a 4-chlorobenzoate-degrading Pseudomonas spec. CBS 3
Hoppe-Seyler's Z. Physiol. Chem.
364
529-535
1983
Pseudomonas sp.
Liu, J.Q.; Kurihara, T.; Miyagi, M.; Esaki, N.; Soda, K.
Reaction mechanism of L-2-haloacid dehalogenase of Pseudomonas sp. YL. Identification of Asp10 as the active site nucleophile by 18O incorporation experiments
J. Biol. Chem.
270
18309-18312
1995
Pseudomonas sp., Pseudomonas sp. 113
Motosugi, K.; Esahi, N.; Soda, K.
Purification and properties of 2-halo acid dehalogenase
Agric. Biol. Chem.
46
837-838
1982
Pseudomonas putida
-
Goldman, P.; Milne, G.W.A.; Kleister, D.B.
Carbon-halogen bond cleavage. 3. Studies on bacterial halidohydrolases
J. Biol. Chem.
243
428-434
1968
Pseudomonas sp.
Soda, K.; Kurihara, T.; Liu, J.Q.; Nardi-Dei, V.; Park, C.; Miyagi, M.; Tsunasawa, S.; Esaki, N.
Bacterial 2-haloacid dehalogenases: structures and catalytic properties
Pure Appl. Chem.
68(11)
2097-2103
1996
Xanthobacter autotrophicus, Pseudomonas sp., Rhizobium sp.
-
Liu, J.Q.; Kurihara, T.; Nardi-Dei, V.; Okamura, T.; Esaki, N.; Soda, K.
Overexpression and feasible purification of a thermostable L-2-halo acid dehalogenase of Pseudomonas sp. YL
Biodegradation
6
223-227
1995
Pseudomonas sp.
Diez, A.; Prieto, M.I.; Alvarez, M.J.; Bautista, J.M.; Puyet, A.; Garrido-Pertierra, A.
Purification and properties of a high-affinity L-2-haloacid dehalogenase from Azotobacter sp. strain RC26
Lett. Appl. Microbiol.
23
279-282
1996
Azotobacter sp., Azotobacter sp. RC26
-
Diez, A.; Prieto, M.I.; Alvarez, M.J.; Bautista, J.M.; Garrido, A.; Puyet, A.
Improved catalytic performance of a 2-haloacid dehalogenase from Azotobacter sp. by ion-exchange immobilisation
Biochem. Biophys. Res. Commun.
220
828-833
1996
Azotobacter sp., Azotobacter sp. RC26
Ordaz., E.; Garrido-Pertierra, A.; Gallego, M.; Puyet, A.
Covalent and metal-chelate immobilization of a modified 2-haloacid dehalogenase for the enzymatic resolution of optically active chloropropionic acid
Biotechnol. Prog.
16
287-291
2000
Pseudomonas sp., Pseudomonas sp. CBS3
Tsang, J.S.H.; Sam, L.
Cloning and characterization of a cryptic haloacid dehalogenase from Burkholderia cepacia MBA4
J. Bacteriol.
181
6003-6009
1999
Burkholderia cepacia (Q51645)
Cairns, S.S.; Cornish, A.; Cooper, R.A.
Cloning, sequencing and expression in Escherichia coli of two Rhizobium sp. genes encoding haloalkonoate dehalogenases of opposite stereospecificity
Eur. J. Biochem.
235
744-749
1996
Rhizobium sp.
Asmara, W.; Murdiyatmo, U.; Baines, A.J.; Bull, A.T.; Hardman, D.J.
Protein engineering of the 2-haloacid halidohydrolase IVa from Pseudomonas cepacia MBA4
Biochem. J.
292
69-74
1993
Burkholderia cepacia, Burkholderia cepacia MBA4
-
Mrsberger, F.M.; Mller, R.; Otto, M.K.; Lingens, F.; Kulbe, K.D.
Purification and characterization of 2-halocarboxylic acid dehalogenase II from Pseudomonas spec. CBS 3
Biol. Chem. Hoppe-Seyler
372
915-922
1991
Pseudomonas sp., Pseudomonas sp. CBS3
Khler, R.; Brokamp, A.; Schwarze, R.; Reiting, R.H.; Schmidt, F.R.J.
Characteristics and DNA-sequence of a cryptic haloalkanoic acid dehalogenase from Agrobacterium tumefaciens RS5
Curr. Microbiol.
36
96-101
1998
Agrobacterium tumefaciens, Agrobacterium tumefaciens RS5
Jones, D.H.A.; Barth, P.T.; Byrom, D.; Thomas, C.M.
Nucleotide sequence of the structural gene encoding a 2-haloalkanoic acid dehalogenase of Pseudomonas putida strain AJ1 and purification of the encoded protein
J. Gen. Microbiol.
138
675-683
1992
Pseudomonas putida, Pseudomonas putida (Q52087), Pseudomonas putida AJ1 (Q52087)
Pang, B.C.M.; Tsang, J.S.H.
Mutagenic analysis of the conserved residues in dehalogenase IVa of Burkholderia cepacia MBA4
FEMS Microbiol. Lett.
204
135-140
2001
Burkholderia cepacia, Burkholderia cepacia MBA4
Van der Ploeg, J.; Van Hall, G.; Janssen, D.B.
Characterization of the haloacid dehalogenase from Xanthobacter autotrophicus GJ10 and sequencing of the dhlB gene
J. Bacteriol.
173
7925-7933
1991
Xanthobacter autotrophicus, Xanthobacter autotrophicus GJ10
Ridder, I.S.; Rozeboom, H.J.; Kalk, K.H.; Dijkstra, B.W.
Crystal structures of intermediates in the dehalogenation of haloalkanoates by L-2-haloacid dehalogenase
J. Biol. Chem.
274
30672-30678
1999
Xanthobacter autotrophicus (Q60099)
Li, Y.F.; Hata, Y.; Fujii, T.; Hisano, T.; Nishihara, M.; Kurihara, T.; Esaki, N.
Crystal structures of reaction intermediates of L-2-haloacid dehalogenase and implications for the reaction mechanism
J. Biol. Chem.
273
15035-15044
1998
Pseudomonas sp.
Ridder, I.S.; Rozeboom, H.J.; Kalk, K.H.; Janssen, D.B.; Dijkstra, B.W.
Three-dimensional structure of L-2-haloacid dehalogenase from Xanthobacter autotrophicus GJ10 complexed with the substrate-analogue formate
J. Biol. Chem.
272
33015-33022
1997
Xanthobacter autotrophicus, Xanthobacter autotrophicus GJ10
Hisano, T.; Hata, Y.; Fujii, T.; Liu, J.Q.; Kurihara, T.; Esaki, N.; Soda, K.
Crystal structures of L-2-haloacid dehalogenase from Pseudomonas sp. YL. An alpha/beta hydrolase structure that is different from the alpha/beta hydrolase fold
J. Biol. Chem.
271
20322-20330
1996
Pseudomonas sp.
Onda, M; Motosugi, K.; Nakajima, H.
A new approach for enzymatic synthesis of D-3-chlorolactic acd from racemic 2,3-dichloropropionic acid by halo acid dehalogenase
Agric. Biol. Chem.
54
3031-3033
1990
Pseudomonas putida, Rhizobium sp., Pseudomonas putida No. 109
-
Hasan, A.K.M.Q.; Motosugi, K.; Esaki, N.; Soda, K.
Total conversion of racemic 2-chloropropionic acid into D-lactate by combination of enzymic and chemical dehalogenations
J. Ferment. Bioeng.
72
481-482
1991
Pseudomonas putida
-
Vyazmensky, M.; Geresh, S.
Substrate specificity and product stereochemistry in the dehalogenation of 2-haloacids with the crude enzyme preparation from Pseudomonas putida
Enzyme Microb. Technol.
22
323-328
1998
Xanthobacter autotrophicus, Pseudomonas putida, Pseudomonas putida No. 109
-
Esaki, N.; Kurihara, T.; Li, Y.F.; Ichiyama, S.
Novel mechanism of enzymatic hydrolysis involving cyanoalanine intermediate revealed by mass spectrometric monitoring of an enzyme reaction
ICR Annual Report
7
46-47
2001
Pseudomonas putida, Pseudomonas putida YL
-
Muridiyatmo, U.; Asmara, W.; Tsang, J.S.H.; Baines, A.J.; Bull, A.T.; Hardmann, D.J.
Molecular biology of the 2-haloacid halidohydrolas IVa from Pseudomonas cepacia MBA4
Biochem. J.
284
87-93
1992
Burkholderia cepacia
-
Schneidet, B.; Mullet, R.; Fran, R.; Lingens, F.
Complete nucleotide sequences and comparison of the structural genes of two 2-haloalkanoic acid dehalogenases from Pseudomonas sp. Strain CBS3
J. Bacteriol.
173
1530-1535
1991
Pseudomonas sp.
Barth, P.T.; Bolton, L.; Thomson, J.C.
Cloning and partial sequencing of an operon encoding two Pseudomonas putida haloalkanoate dehalogenases of opposite stereospecificity
J. Bacteriol.
174
2612-2619
1992
Pseudomonas putida, Pseudomonas putida AJ1
Kawasaki, H.; Toyama, T.; Maeda, T.; Nishino, H.; Tonomura K.
Cloning and sequence analysis of a plasmid-encoded 2-haloacid dehalogenases gene from Pseudomonas putida No. 109
Biosci. Biotechnol. Biochem.
58
160-163
1994
Pseudomonas putida, Pseudomonas putida No. 109
Nardi-Dei, V.; Kurihara, T.; Okamura, T.; Liu, J.Q.; Koshijawa, H.; Ozaki, H.; Terashima, Y.; Esaki, N.; Soda, K.
Comparative studies of genes encoding thermostable L-2-halo acid dehalogenase from Pseudomonas sp. strain YL, other dehalogenases, and two related hypothetical proteins from Escherichia coli
Appl. Environ. Microbiol.
60
3375-3380
1994
Pseudomonas sp.
van der Ploeg, J.; Janssen D.B.
Sequence analysis of the upstream region of dhlB, the gene encoding haloalkanoic acid dehalogease of Xanthobacter autotrophicus GJ10
Biodegradation
6
257-263
1995
Xanthobacter autotrophicus, Xanthobacter autotrophicus GJ10
Kurihara, T.; Liu, J.Q.; Nardi-Dei, V.; Koshikawa, H.; Esaki, N.; Soda, K.
Comprehensive site-directed mutagenesis of L-2-halo acid dehalogenase to probe catalytic amino acid residues
J. Biochem.
117
1317-1322
1995
Burkholderia cepacia, Burkholderia cepacia MBA4, Moraxella sp., Moraxella sp. B, Pseudomonas putida, Pseudomonas putida AJ1, Pseudomonas putida No. 109, Pseudomonas sp., Xanthobacter autotrophicus, Xanthobacter autotrophicus GJ10
Higgins, T.P.; Hope, S.J.; Effendi, A.J.; Dawson, S.; Dancer, B.N.
Biochemical and molecular characterisation of the 2,3-dichloro-1-propanol dehalogenase and stereospecific haloalkanoic dehalogenases from a versatile Agrobacterium sp
Biodegradation
16
485-492
2005
Agrobacterium sp.
Rye, C.A.; Isupov, M.N.; Lebedev, A.A.; Littlechild, J.A.
An order-disorder twin crystal of L-2-haloacid dehalogenase from Sulfolobus tokodaii
Acta Crystallogr. Sect. D
63
926-930
2007
Sulfurisphaera tokodaii
Yamamoto, H.; Takio, K.; Sugahara, M.; Kunishima, N.
Structure of a haloacid dehalogenase superfamily phosphatase PH1421 from Pyrococcus horikoshii OT3: oligomeric state and thermoadaptation mechanism
Acta Crystallogr. Sect. D
64
1068-1077
2008
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Rye, C.A.; Isupov, M.N.; Lebedev, A.A.; Littlechild, J.A.
Biochemical and structural studies of a L-haloacid dehalogenase from the thermophilic archaeon Sulfolobus tokodaii
Extremophiles
13
179-190
2009
Sulfurisphaera tokodaii (Q96XE7), Sulfurisphaera tokodaii, Sulfurisphaera tokodaii 7 (Q96XE7)
Kurihara, T.
A mechanistic analysis of enzymatic degradation of organohalogen compounds
Biosci. Biotechnol. Biochem.
75
189-198
2011
Pseudomonas sp.
Huang, J.; Xin, Y.; Zhang, W.
Isolation, characterization and identification of a Paracoccus sp. 2-haloacid-degrading bacterium from the marine sponge Hymeniacidon perlevis
J. Basic Microbiol.
51
318-324
2011
Hymeniacidon perlevis
Huang, J.; Xin, Y.; Cao, X.; Zhang, W.
Phylogenetic diversity and characterization of 2-haloacid degrading bacteria from the marine sponge Hymeniacidon perlevis
World J. Microbiol. Biotechnol.
27
1787-1794
2011
Hymeniacidon perlevis
Bachas-Daunert, P.G.; Sellers, Z.P.; Wei, Y.
Detection of halogenated organic compounds using immobilized thermophilic dehalogenase
Anal. Bioanal. Chem.
395
1173-1178
2009
Sulfurisphaera tokodaii
Bachas-Daunert, P.G.; Law, S.A.; Wei, Y.
Characterization of a recombinant thermostable dehalogenase isolated from the hot spring thermophile Sulfolobus tokodaii
Appl. Biochem. Biotechnol.
159
382-393
2009
Sulfurisphaera tokodaii (Q96XE7), Sulfurisphaera tokodaii 7 (Q96XE7)
Novak, H.R.; Sayer, C.; Isupov, M.N.; Paszkiewicz, K.; Gotz, D.; Spragg, A.M.; Littlechild, J.A.
Marine Rhodobacteraceae L-haloacid dehalogenase contains a novel His/Glu dyad that could activate the catalytic water
FEBS J.
280
1664-1680
2013
Rhodobacteraceae bacterium UDC319 (M9P6K0)
Liao, L.; Sun, X.; Zeng, Y.; Luo, W.; Yu, Y.; Chen, B.
A new L-haloacid dehalogenase from the Arctic psychrotrophic Pseudoalteromonas sp. BSW20308
Polar Biol.
38
1161-1169
2015
Pseudoalteromonas sp., Pseudoalteromonas sp. BSW20308
-
Wang, Y.; Xin, Y.; Cao, X.; Xue, S.
Enhancement of L-2-haloacid dehalogenase expression in Pseudomonas stutzeri DEH138 based on the different substrate specificity between dehalogenase-producing bacteria and their dehalogenases
World J. Microbiol. Biotechnol.
31
669-673
2015
Pseudomonas stutzeri, Pseudomonas stutzeri DEH138
Satpathy, R.; Konkimalla, V.B.; Ratha, J.
In silico phylogenetic analysis and molecular modelling study of 2-haloalkanoic acid dehalogenase enzymes from bacterial and fungal origin
Adv. Bioinformatics
2016
8701201
2016
Fusarium oxysporum, Solemya velum, Metarhizium robertsii, Staphylococcus massiliensis
Peng, P.; Zheng, Y.; Koehorst, J.J.; Schaap, P.J.; Stams, A.J.M.; Smidt, H.; Atashgahi, S.
Concurrent haloalkanoate degradation and chlorate reduction by Pseudomonas chloritidismutans AW-1T
Appl. Environ. Microbiol.
83
e00325-17
2017
Stutzerimonas chloritidismutans, Stutzerimonas chloritidismutans AW-1T
Adamu, A.; Wahab, R.A.; Shamsir, M.S.; Aliyu, F.; Huyop, F.
Deciphering the catalytic amino acid residues of l-2-haloacid dehalogenase (DehL) from Rhizobium sp. RC1 An in silico analysis
Comput. Biol. Chem.
70
125-132
2017
Rhizobium sp. RC1 (Q53187)
Kumar, A.; Pillay, B.; Olaniran, A.O.
L-2-Haloacid dehalogenase from Ancylobacter aquaticus UV5 Sequence determination and structure prediction
Int. J. Biol. Macromol.
83
216-225
2016
Ancylobacter aquaticus, Ancylobacter aquaticus UV5
Adamu, A.; Shamsir, M.S.; Wahab, R.A.; Parvizpour, S.; Huyop, F.
Multi-template homology-based structural model of L-2-haloacid dehalogenase (DehL) from Rhizobium sp. RC1
J. Biomol. Struct. Dyn.
35
3285-3296
2017
Rhizobium sp. RC1 (Q53187)
Wang, Y.; Cao, X.; Feng, Y.; Xue, S.
Environment-induced conformational and functional changes of L-2-haloacid dehalogenase
J. Biosci. Bioeng.
121
491-496
2016
Pseudomonas putida (Q52087), Pseudomonas putida
Adamu, A.; Abdul Wahab, R.; Aliyu, F.; Abdul Razak, F.I.; Mienda, B.S.; Shamsir, M.S.; Huyop, F.
Theoretical analyses on enantiospecificity of L-2-haloacid dehalogenase (DehL) from Rhizobium sp. RC1 towards 2-chloropropionic acid
J. Mol. Graph. Model.
92
131-139
2019
Rhizobium sp. RC1 (Q53187)
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