Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 3.6.5.1 - heterotrimeric G-protein GTPase

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
1-acylglycerophosphocholine o-acyltransferase deficiency
Ablation of ALCAT1 Mitigates Hypertrophic Cardiomyopathy through Effects on Oxidative Stress and Mitophagy.
Abetalipoproteinemia
Insights from human congenital disorders of intestinal lipid metabolism.
Acidosis
Coronary arteriolar dilation to acidosis: role of ATP-sensitive potassium channels and pertussis toxin-sensitive G proteins.
Effect of acidosis on PTH-dependent renal adenylate cyclase in phosphorus deprivation: role of G proteins.
Acquired Immunodeficiency Syndrome
Population genetics of Cryptosporidium meleagridis in humans and birds: evidence for cross-species transmission.
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Acromegaly
ACTH-independent massive bilateral adrenal disease (AIMBAD): a subtype of Cushing's syndrome with major diagnostic and therapeutic implications.
Analysis of the Gs alpha gene in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues.
G protein Gs alpha (GNAS 1), the probable candidate gene for Albright hereditary osteodystrophy, is assigned to human chromosome 20q12-q13.2.
Molecular biology of growth-hormone-secreting human pituitary tumours: biochemical consequences and potential clinical significance.
Study of the multiple endocrine neoplasia type 1, growth hormone-releasing hormone receptor, Gs alpha, and Gi2 alpha genes in isolated familial acromegaly.
[Recent progress in the diagnosis of growth hormone (GH) disorders]
Adenocarcinoma
ARHGAP25 Inhibits Pancreatic Adenocarcinoma Growth by Suppressing Glycolysis via AKT/mTOR Pathway.
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice.
Impaired TGF-beta responses in peripheral T cells of G alpha i2-/- mice.
In vivo restoration of RhoB expression leads to ovarian tumor regression.
Significance and prognostic role of human epidermal growth factor receptor 2 and RAB1A expression in gastric cancer.
Suppression of the proliferation and migration of oncogenic ras-dependent cell lines, cultured in a three-dimensional collagen matrix, by flavonoid-structured molecules.
Adenocarcinoma of Lung
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib.
KRAS Mutations in Lung Cancer.
RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.
Silencing of ARL14 Gene Induces Lung Adenocarcinoma Cells to a Dormant State.
Systemic analyses of expression patterns and clinical features for GIMAPs family members in lung adenocarcinoma.
Adenoma
Activating mutations of the Gs alpha gene are associated with low levels of Gs alpha protein in growth hormone-secreting tumors.
Analysis of the Gs alpha gene in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues.
Constitutive activation of the Gs alpha protein-adenylate cyclase pathway may not be sufficient to generate toxic thyroid adenomas.
Constitutively active Gs alpha is associated with an increased phosphodiesterase activity in human growth hormone-secreting adenomas.
Expression of functional stimulatory guanine nucleotide binding protein in nonfunctioning thyroid adenomas is not correlated to adenylate cyclase activity and growth of these tumors.
Functioning and nonfunctioning thyroid adenomas involve different molecular pathogenetic mechanisms.
G protein oncogenes in pituitary tumors.
Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice.
Gs alpha--identification of a gene highly expressed by insulinoma and other endocrine tumors.
Heterozygous gsp mutation renders ion channels of human somatotroph adenoma cells unresponsive to growth hormone-releasing hormone.
Low prevalence of Gs alpha mutations in śomatotroph adenomas of children and adolescents.
Molecular screening for somatic mutations in corticotropic adenomas of dogs with pituitary-dependent hyperadrenocorticism.
Oncogenic potential of a mutant human thyrotropin receptor expressed in FRTL-5 cells.
Overexpression of Gs alpha subunit in thyroid tumors bearing a mutated Gs alpha gene.
Point mutations of ras and Gs alpha subunit genes in thyroid tumors.
Prevalence of Gs alpha mutations in Korean patients with pituitary adenomas.
Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction-primer-introduced restriction analysis.
Thyrotropin receptor: a role for thyroid tumourigenesis?
[Genetic changes in human pituitary adenomas]
[Pathophysiology and gene abnormalities of endocrine tumors]
Adenoma, Islet Cell
Gs alpha--identification of a gene highly expressed by insulinoma and other endocrine tumors.
Adenomatous Polyposis Coli
BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes.
Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1.
Adenoviridae Infections
Adenovirus infection of myocardial cells induces an enhanced sensitivity to beta-adrenergic agonists by increasing the concentration of the stimulatory G-protein.
Dynamin2 S-nitrosylation regulates adenovirus type 5 infection of epithelial cells.
Adrenocortical Adenoma
Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction-primer-introduced restriction analysis.
Adrenocortical Hyperfunction
Molecular screening for somatic mutations in corticotropic adenomas of dogs with pituitary-dependent hyperadrenocorticism.
African Swine Fever
Endosomal maturation, Rab7 GTPase and phosphoinositides in African swine fever virus entry.
Identification of genes encoding zinc finger proteins, non-histone chromosomal HMG protein homologue, and a putative GTP phosphohydrolase in the genome of Chilo iridescent virus.
Albinism, Ocular
Ebi/AP-1 suppresses pro-apoptotic genes expression and permits long-term survival of Drosophila sensory neurons.
Alopecia
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Alzheimer Disease
Alterations in the activity of adenylate cyclase and high affinity GTPase in Alzheimer's disease.
Area specific alterations in muscarinic stimulated low Km GTPase activity in aging and Alzheimer's disease: implications for altered signal transduction.
Attenuation of muscarinic receptor-G-protein interaction in Alzheimer disease.
Densitometric analysis of Galphao protein subunit levels from postmortem Alzheimer disease hippocampal and prefrontal cortical membranes.
Functional gene networks reveal distinct mechanisms segregating in migraine families.
G protein subunit levels in fibroblasts from familial Alzheimer's disease patients: lower levels of high molecular weight Gs alpha isoform in patients with decreased beta-adrenergic receptor stimulated cAMP formation.
Increased phosphorylation of elongation factor 2 in Alzheimer's disease.
Mitophagy in degenerative joint diseases.
Phosphoinositide hydrolysis, G alpha q, phospholipase C, and protein kinase C in post mortem human brain: effects of post mortem interval, subject age, and Alzheimer's disease.
Regionally selective alterations in G protein subunit levels in the Alzheimer's disease brain.
Regulation of GTPase and adenylate cyclase activity by amyloid beta-peptide and its fragments in rat brain tissue.
S-Nitrosylation of Dynamin-Related Protein 1 Mediates Mutant Huntingtin-Induced Mitochondrial Fragmentation and Neuronal Injury in Huntington's Disease.
Suppression of the kinase for elongation factor 2 alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease.
Amyotrophic Lateral Sclerosis
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.
Diverse roles of Rho family GTPases in neuronal development, survival, and death.
SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis.
Anemia
Assessment of growth and differentiation processes in myelodysplastic syndromes by PCR analysis of Galpha16 and 5'-lipoxygenase.
Loss of Dynamin 2 GTPase function results in microcytic anaemia.
Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.
Anemia, Refractory
Assessment of growth and differentiation processes in myelodysplastic syndromes by PCR analysis of Galpha16 and 5'-lipoxygenase.
Aortic Aneurysm, Abdominal
Targeting Mitochondrial Fission as a Potential Therapeutic for Abdominal Aortic Aneurysm.
Aortic Coarctation
Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice.
Arrhythmias, Cardiac
[Animal in vivo model of arrhythmia for genes target identification for 5-amino-exo-3-azatricyclo[5.2.1.0(2,6)]decan-4-one].
Arthritis
Silencing the Expression of Ras Family GTPase Homologues Decreases Inflammation and Joint Destruction in Experimental Arthritis.
Arthritis, Rheumatoid
CTLA-4IG suppresses reactive oxygen species by preventing synovial adherent cell-induced inactivation of Rap1, a Ras family GTPASE mediator of oxidative stress in rheumatoid arthritis T cells.
Inflammatory bowel disease: dysfunction of autophagy?
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
The GTPase Rac regulates the proliferation and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients.
[Genetic polymorphisms of ARL15 and HLA-DMA are associated with rheumatoid arthritis in Han population from northwest China].
Arthus Reaction
Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation.
Asthma
Association Analysis of Member RAS Oncogene Family Gene Polymorphisms with Aspirin Intolerance in Asthmatic Patients.
Differential coupling of G alpha q family of G-protein to muscarinic M1 receptor and neurokinin-2 receptor.
GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy.
Heterotrimeric G protein signaling: role in asthma and allergic inflammation.
Increased expression of G alpha q protein in bronchial smooth muscle of mice with allergic bronchial asthma.
Astrocytoma
Gq/11 communicates with thromboxane A2 receptors in human astrocytoma cells, rabbit astrocytes and human platelets.
Isolation and characterization of a novel cDNA which identifies both neural-specific and ubiquitously expressed GS alpha mRNAs.
The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility.
Ataxia
Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease.
GTPase Regulator Associated with Focal Adhesion Kinase 1 (GRAF1) Immunoglobulin-Associated Ataxia and Neuropathy.
Impaired turnover of hyperfused mitochondria in severe axonal neuropathy due to a novel DRP1 mutation.
Ataxia Telangiectasia
Identification of genes differentially expressed between benign and osteopontin transformed rat mammary epithelial cells.
Atherosclerosis
Early growth response transcription factor EGR-1 regulates Galphaq gene in megakaryocytic cells.
Irgm1 promotes M1 but not M2 macrophage polarization in atherosclerosis pathogenesis and development.
Atrial Fibrillation
Expression of the angiotensin II, rac GTPase activating protein 1, signal transducer and activator of transcription 3 signaling pathway in patients with permanent atrial fibrillation and rheumatic heart disease.
Autoimmune Diseases
Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response.
Bacterial Infections
Identification of a New Class of FtsZ Inhibitors by Structure-Based Design and in Vitro Screening.
The Rab1 GTPase of Sciaenops ocellatus modulates intracellular bacterial infection.
Blast Crisis
Structural insights into the activation of the RhoA GTPase by the lymphoid blast crisis (Lbc) oncoprotein.
Blindness
Ablation of retinal ciliopathy protein RPGR results in altered photoreceptor ciliary composition.
Ciliopathy-associated protein CEP290 modifies the severity of retinal degeneration due to loss of RPGR.
Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models.
Identification and characterization of a novel RPGR isoform in human retina.
Leber congenital amaurosis caused by an RPGRIP1 mutation shows treatment potential.
Mitochondrial oxidative phosphorylation in autosomal dominant optic atrophy.
Molecular genetics of colour vision deficiencies.
Phenotypic variation and genotype-phenotype discordance in canine cone-rod dystrophy with an RPGRIP1 mutation.
Species-specific subcellular localization of RPGR and RPGRIP isoforms: implications for the phenotypic variability of congenital retinopathies among species.
The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors.
The RPGRIP1-related retinal phenotype in children.
Blister
Heterotrimeric G protein signaling governs the cortical stability during apical constriction in Drosophila gastrulation.
Involvement of small GTPases Rho and Rac in the invasion of rat ascites hepatoma cells.
Bone Diseases
Periostin, a novel marker of intramembranous ossification, is expressed in fibrous dysplasia and in c-Fos-overexpressing bone lesions.
Bone Diseases, Metabolic
Continuous activation of G alpha q in osteoblasts results in osteopenia through impaired osteoblast differentiation.
Bone Resorption
Calmodulin interacts with Rab3D and modulates osteoclastic bone resorption.
Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation.
Bradycardia
G-protein signaling participates in the development of diabetic cardiomyopathy.
Brain Diseases
Clinical Assessments and EEG Analyses of Encephalopathies Associated With Dynamin-1 Mutation.
De novo missense variant in the GTPase effector domain (GED) of DNM1L leads to static encephalopathy and seizures.
Brain Injuries
Rit GTPase signaling promotes immature hippocampal neuronal survival.
[Role of immune-related GTPase M1 in cortical neurons autophagy of mice with sepsis-induced brain injury].
Brain Neoplasms
An Arf/Rab cascade controls the growth and invasiveness of glioblastoma.
Brain tumors predominantly express the neurofibromatosis type 1 gene transcripts containing the 63 base insert in the region coding for GTPase activating protein-related domain.
Breast Neoplasms
A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells.
Aberrant expression of Rab1A and its prognostic significance in human colorectal cancer.
Abnormal expression of Rap2A as a prognostic marker for human breast cancer.
ADP-ribosylation factor 1 expression regulates epithelial-mesenchymal transition and predicts poor clinical outcome in triple-negative breast cancer.
ARF1 controls Rac1 signaling to regulate migration of MDA-MB-231 invasive breast cancer cells.
ARF1 regulates adhesion of MDA-MB-231 invasive breast cancer cells through formation of focal adhesions.
ARF1 regulates the Rho/MLC pathway to control EGF-dependent breast cancer cell invasion.
Breast cancer cell migration is regulated through junctional adhesion molecule-A-mediated activation of Rap1 GTPase.
Characterization of a P-Rex1 gene signature in breast cancer cells.
Circadian locomotor output cycles kaput affects the proliferation and migration of breast cancer cells by regulating the expression of E-cadherin via IQ motif containing GTPase activating protein 1.
Cooperative interaction between the MUC1-C oncoprotein and the Rab31 GTPase in estrogen receptor-positive breast cancer cells.
Dichotomous roles of claudins as tumor promoters or suppressors: lessons from knockout mice.
Ectopic expression of Rsu-1 results in elevation of p21CIP and inhibits anchorage-independent growth of MCF7 breast cancer cells.
Essential role of the cancer stem/progenitor cell marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast cancer cells.
Expression of bcl-2, c-erbB-2, p53, and p21 (waf1-cip1) protein in thyroid carcinomas.
Farnesyl transferase inhibitor treatment of breast cancer cells leads to altered RhoA and RhoC GTPase activity and induces a dormant phenotype.
Focus on Cdc42 in Breast Cancer: New Insights, Target Therapy Development and Non-Coding RNAs.
G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion.
G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion.
Gonadotropin-releasing hormone receptor activates GTPase RhoA and inhibits cell invasion in the breast cancer cell line MDA-MB-231.
GPR116, an Adhesion G-Protein-Coupled Receptor, Promotes Breast Cancer Metastasis via the G?q-p63RhoGEF-Rho GTPase Pathway.
High glucose levels promote the proliferation of breast cancer cells through GTPases.
Immunohistochemical evalulation of activated Ras and Rac1 as potential downstream effectors of aquaporin-5 in breast cancer in vivo.
Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells.
IQGAP3 Overexpression Correlates With Poor Prognosis and Radiation Therapy Resistance in Breast Cancer.
Knockdown of Ran GTPase expression inhibits the proliferation and migration of breast cancer cells.
Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state.
MicroRNA-22 Suppresses Breast Cancer Cell Growth and Increases Paclitaxel Sensitivity by Targeting NRAS.
miR?139?3p suppresses the invasion and migration properties of breast cancer cells by targeting RAB1A.
Nano-encapsulation of a novel anti-Ran-GTPase peptide for blockade of regulator of chromosome condensation 1 (RCC1) function in MDA-MB-231 breast cancer cells.
Overexpression of Ran GTPase Components Regulating Nuclear Export, but not Mitotic Spindle Assembly, Marks Chromosome Instability and Poor Prognosis in Breast Cancer.
p38{gamma} promotes breast cancer cell motility and metastasis through regulation of RhoC GTPase, cytoskeletal architecture, and a novel leading edge behavior.
Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT.
Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation.
RASAL2 down-regulation in ovarian cancer promotes epithelial-mesenchymal transition and metastasis.
Reduced expression of Snail decreases breast cancer cell motility by downregulating the expression and inhibiting the activity of RhoA GTPase.
Reduced RhoA expression enhances breast cancer metastasis with a concomitant increase in CCR5 and CXCR4 chemokines signaling.
Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23.
Signals and pathways regulating nucleolar retention of novel putative nucleolar GTPase NGP-1(GNL-2).
Target-Driven Design of a Coumarinyl Chalcone Scaffold Based Novel EF2 Kinase Inhibitor Suppresses Breast Cancer Growth In Vivo.
TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia.
The anti-psychotic drug pimozide is a novel chemotherapeutic for breast cancer.
The FTO/miR-181b-3p/ARL5B signaling pathway regulates cell migration and invasion in breast cancer.
The Galphai and Galphaq proteins mediate the effects of melatonin on steroid/thyroid hormone receptor transcriptional activity and breast cancer cell proliferation.
The R-Ras GTPase mediates cross talk between estrogen and insulin signaling in breast cancer cells.
The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.
The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling.
The UPR Transducer IRE1 Promotes Breast Cancer Malignancy by Degrading Tumor Suppressor microRNAs.
Therapeutic IMC-C225 antibody inhibits breast cancer cell invasiveness via Vav2-dependent activation of RhoA GTPase.
Transducin (?)-like 1 X-linked receptor 1 promotes proliferation and tumorigenicity in human breast cancer via activation of beta-catenin signaling.
[Effect of GTPase activating protein Git2 on metastasis in breast cancer].
Burkitt Lymphoma
Detection of Chromosomal Translocation in Hematologic Malignancies by a Novel DNA-Based Looped Ligation Assay (LOLA).
Carcinogenesis
A Conserved Role of IQGAP1 in Regulating TOR Complex 1.
A PI3K/AKT Scaffolding Protein, IQ Motif-Containing GTPase Associating Protein 1 (IQGAP1), Promotes Head and Neck Carcinogenesis.
A transcriptional cross-talk between RhoA and c-Myc inhibits the RhoA/Rock-dependent cytoskeleton.
Aberrant expression of RAB1A in human tongue cancer.
Analysis of the Gs alpha gene in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues.
ARHGAP25 Inhibits Pancreatic Adenocarcinoma Growth by Suppressing Glycolysis via AKT/mTOR Pathway.
c-Fos-dependent induction of the small ras-related GTPase Rab11a in skin carcinogenesis.
Conformational resolution of nucleotide cycling and effector interactions for multiple small GTPases determined in parallel.
CRMP5-associated GTPase (CRAG) Is a Candidate Driver Gene for Colorectal Cancer Carcinogenesis.
Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma.
DOCK4, a GTPase activator, is disrupted during tumorigenesis.
Downregulation of miR?143 modulates KRAS expression in colorectal carcinoma cells.
Effect of increased expression of both ras-related C3 botulinum toxin substrate 1 and p21-activated kinase 1 in patients with N0M0 upper urinary tract urothelial carcinoma and cancer-free surgical margins.
Gs alpha mutation may be uncommon in patients with multiple endocrine neoplasia type 1.
Hepatic Rac1 GTPase contributes to liver-mediated basal immune homeostasis and LPS-induced endotoxemia.
Hepatitis B Virus X Protein Stimulates Proliferation, Wound Closure and Inhibits Apoptosis of HuH-7 Cells via CDC42.
High expression of immunity-related GTPase family M protein in glioma promotes cell proliferation and autophagy protein expression.
High frequency of activated K-ras codon 15 mutant in colorectal carcinomas from Taiwanese patients.
Induction of human microsomal prostaglandin E synthase 1 by activated oncogene RhoA GTPase in A549 human epithelial cancer cells.
Induction of MAP Kinase Phosphatase 3 through Erk/MAP Kinase Activation in Three Oncogenic Ras (H-, K- and N-Ras) Expressing NIH/3T3 Mouse Embryonic Fibroblasts.
Influenza Virus Induces Cholesterol-Enriched Endocytic Recycling Compartments for Budozone Formation via Cell Cycle-Independent Centrosome Maturation.
Low incidence of the stimulatory G protein alpha-subunit mutations in autonomously functioning thyroid adenomas in Japan.
Low prevalence of Gs alpha mutations in śomatotroph adenomas of children and adolescents.
Molecular dynamics simulations of Gly-12-->Val mutant of p21(ras): dynamic inhibition mechanism.
Molecular screening for somatic mutations in corticotropic adenomas of dogs with pituitary-dependent hyperadrenocorticism.
Mutational analyses of candidate genes in human squamous cell carcinomas.
Odontogenic myxomas are not associated with activating mutations of the Gs alpha gene.
Oncogenic potential of a mutant human thyrotropin receptor expressed in FRTL-5 cells.
Overexpression of IQGAP1 promotes the angiogenesis of esophageal squamous cell carcinoma through the AKT and ERK?mediated VEGF?VEGFR2 signaling pathway.
Pituitary adenomas: screening for G alpha q mutations.
Point mutations of ras and Gs alpha subunit genes in thyroid tumors.
Potent farnesyltransferase inhibitor ABT-100 abrogates acute allograft rejection.
Rab1A is an mTORC1 activator and a colorectal oncogene.
Rab35 GTPase and cancer: Linking membrane trafficking to tumorigenesis.
RAF1/BRAF dimerization integrates the signal from RAS to ERK and ROK?.
Real-Time In-Cell NMR Reveals the Intracellular Modulation of GTP-Bound Levels of RAS.
Relative molecular similarity in selected chemical carcinogens and the nucleoside triphosphate chain.
Reversible SUMOylation of TBL1-TBLR1 Regulates ?-Catenin-Mediated Wnt Signaling.
Role of GTPases and GTPase regulatory proteins in oncogenesis.
Systemic Delivery of MicroRNA-101 Potently Inhibits Hepatocellular Carcinoma In Vivo by Repressing Multiple Targets.
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells.
The arginine finger of RasGAP helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP.
The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis-activation and the consequent initiation of Rho GTPase-mediated signaling.
The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.
The RAS-related GTPase RHOB confers resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer via an AKT-dependent mechanism.
The thyrotropin receptor (TSH-R) is not an oncogene for thyroid tumors: structural studies of the TSH-R and the alpha-subunit of Gs in human thyroid neoplasms.
Transducin (?)-like 1 X-linked receptor 1 correlates with clinical prognosis and clinicopathological characteristics in human solid carcinomas.
Transducin (?)-like 1 X-linked receptor 1 promotes gastric cancer progression via the ERK1/2 pathway.
Transducin ?-like 1 X-linked receptor 1 suppresses cisplatin sensitivity in nasopharyngeal carcinoma via activation of NF-?B pathway.
Tyr42 phosphorylation of RhoA GTPase promotes tumorigenesis through nuclear factor (NF)-?B.
[Pathophysiology and gene abnormalities of endocrine tumors]
Carcinoid Tumor
Gs alpha--identification of a gene highly expressed by insulinoma and other endocrine tumors.
Mechanical stimulation activates Galphaq signaling pathways and 5-hydroxytryptamine release from human carcinoid BON cells.
Carcinoma
Amplified expression of p21 ras protein in hormone-dependent mammary carcinomas of humans and rodents.
Differential partitioning of Galphai1 with the cellular microtubules: a possible mechanism of development of Taxol resistance in human ovarian carcinoma cells.
Downregulation of RhoB GTPase confers resistance to cisplatin in human laryngeal carcinoma cells.
Growth rate dependence of differential incorporation of a guanosine triphosphate photoaffinity probe into the alpha subunit of a guanine nucleotide binding protein, Gs, from metastatic variants of B16 melanoma cells.
Gs alpha--identification of a gene highly expressed by insulinoma and other endocrine tumors.
GTPase Regulator Associated with Focal Adhesion Kinase 1 (GRAF1) Immunoglobulin-Associated Ataxia and Neuropathy.
Heat stress stimulates high affinity GTPase in cervical carcinoma cells.
High expression of Ran GTPase is associated with local invasion and metastasis of human clear cell renal cell carcinoma.
Immunohistochemical study of RhoC GTPase in oral squamous cell carcinoma.
Immunotoxins in cancer therapy: Review and update.
Modulation of RhoA GTPase Activity Sensitizes Human Cervix Carcinoma Cells to ?-Radiation by Attenuating DNA Repair Pathways.
Mutational analyses of candidate genes in human squamous cell carcinomas.
Overexpression of Septin1: Possible contribution to the development of oral cancer.
Phenotypic analysis of ovarian carcinoma: polypeptide expression in benign, borderline and malignant tumors.
RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck.
Shenqi Fuzheng Injection Reverses Cisplatin Resistance through Mitofusin-2-Mediated Cell Cycle Arrest and Apoptosis in A549/DDP Cells.
Somatic Mutations in LRRK2 Identify a Subset of Invasive Mammary Carcinomas Associated with High Mutation Burden.
The peptide recognized by HLA-A68.2-restricted, squamous cell carcinoma of the lung-specific cytotoxic T lymphocytes is derived from a mutated elongation factor 2 gene.
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Transducin (?)-like 1 X-linked receptor 1 correlates with clinical prognosis and clinicopathological characteristics in human solid carcinomas.
[Effects of RAB1A on the proliferation, invasion, and metastasis of tongue squamous cell carcinoma cells].
Carcinoma, Embryonal
c-Jun amino-terminal kinase is regulated by Galpha12/Galpha13 and obligate for differentiation of P19 embryonal carcinoma cells by retinoic acid.
G alpha 13 signals via p115RhoGEF cascades regulating JNK1 and primitive endoderm formation.
Carcinoma, Hepatocellular
A novel KLF6-Rho GTPase axis regulates hepatocellular carcinoma cell migration and dissemination.
Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A.
Aberrant expression of Rab1A and its prognostic significance in human colorectal cancer.
Clinical significance of mitofusin-2 and its signaling pathways in hepatocellular carcinoma.
Concanavalin A/IFN-gamma triggers autophagy-related necrotic hepatocyte death through IRGM1-mediated lysosomal membrane disruption.
DLC1 suppresses distant dissemination of human hepatocellular carcinoma cells in nude mice through reduction of RhoA GTPase activity, actin cytoskeletal disruption and down-regulation of genes involved in metastasis.
DNA methylation-mediated silencing of matricellular protein dermatopontin promotes hepatocellular carcinoma metastasis by ?3?1 integrin-Rho GTPase signaling.
Expression analysis and implication of Rab1A in gastrointestinal relevant tumor.
MicroRNA-1178-3p suppresses the growth of hepatocellular carcinoma by regulating transducin (beta)-like 1 X-linked receptor 1.
miR-15b-5p induces endoplasmic reticulum stress and apoptosis in human hepatocellular carcinoma, both in vitro and in vivo, by suppressing Rab1A.
miR-634 exhibits anti-tumor activities toward hepatocellular carcinoma via Rab1A and DHX33.
Ras Homolog Family Member F, Filopodia Associated Promotes Hepatocellular Carcinoma Metastasis by Altering the Metabolic Status of Cancer Cells Through RAB3D.
The STAR of the DLC family.
Transducin (Beta)-Like 1 X-Linked Receptor 1 Correlates with Clinical Prognosis and Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma.
Ubiquitin-specific protease 2a promotes hepatocellular carcinoma progression via deubiquitination and stabilization of RAB1A.
Carcinoma, Intraductal, Noninfiltrating
Downregulation of Rap1Gap: A Switch from DCIS to Invasive Breast Carcinoma via ERK/MAPK Activation.
Carcinoma, Medullary
Point mutations of ras and Gs alpha subunit genes in thyroid tumors.
Carcinoma, Non-Small-Cell Lung
AGO2 promotes tumor progression in KRAS-driven mouse models of non-small cell lung cancer.
Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis.
In Silico Screening of Mutated K-Ras Inhibitors from Malaysian Typhonium flagelliforme for Non-Small Cell Lung Cancer.
Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer.
Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display.
Prognostic value of KRAS/TP53/PIK3CA in non-small cell lung cancer.
Rab8 GTPase regulates Klotho-mediated inhibition of cell growth and progression by directly modulating its surface expression in human non-small cell lung cancer.
Ran GTPase induces EMT and enhances invasion in non-small cell lung cancer cells through activation of PI3K-AKT pathway.
Carcinoma, Ovarian Epithelial
An essential role for Ran GTPase in epithelial ovarian cancer cell survival.
Endothelin-1/endothelin A receptor axis activates RhoA GTPase in epithelial ovarian cancer.
Evaluation of core serous epithelial ovarian cancer genes as potential prognostic markers and indicators of the underlying molecular mechanisms using an integrated bioinformatics analysis.
Rab25 is responsible for phosphoinositide 3-kinase/AKT?mediated cisplatin resistance in human epithelial ovarian cancer cells.
Carcinoma, Papillary
Overexpression of Gs alpha subunit in thyroid tumors bearing a mutated Gs alpha gene.
Point mutations of ras and Gs alpha subunit genes in thyroid tumors.
Carcinoma, Renal Cell
High expression of Ran GTPase is associated with local invasion and metastasis of human clear cell renal cell carcinoma.
Immunotoxins in cancer therapy: Review and update.
Carcinoma, Squamous Cell
GTPase Regulator Associated with Focal Adhesion Kinase 1 (GRAF1) Immunoglobulin-Associated Ataxia and Neuropathy.
Mutational analyses of candidate genes in human squamous cell carcinomas.
RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck.
The peptide recognized by HLA-A68.2-restricted, squamous cell carcinoma of the lung-specific cytotoxic T lymphocytes is derived from a mutated elongation factor 2 gene.
[Effects of RAB1A on the proliferation, invasion, and metastasis of tongue squamous cell carcinoma cells].
Cardiomegaly
Cardiac-directed expression of adenylyl cyclase reverses electrical remodeling in cardiomyopathy.
Cardiac-specific overexpression of Galphaq alters excitation-contraction coupling in isolated cardiac myocytes.
Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice.
Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure.
GTPase Activating Protein (Sh3 Domain) Binding Protein 1 Regulates the Processing of MicroRNA-1 during Cardiac Hypertrophy.
Identification of transcription factor E3 (TFE3) as a receptor-independent activator of G{alpha}16: Gene regulation by nuclear G{alpha} subunit and its activator.
Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy.
Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice.
MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq.
MicroRNA-101 inhibits rat cardiac hypertrophy by targeting Rab1a.
PKC translocation without changes in Galphaq and PLC-beta protein abundance in cardiac hypertrophy and failure.
Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy.
RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis.
Signal transduction during cardiac hypertrophy: the role of G alpha q, PLC beta I, and PKC.
The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex.
The IP3 receptor regulates cardiac hypertrophy in response to select stimuli.
Transgenic Galphaq overexpression induces cardiac contractile failure in mice.
Cardiomyopathies
Adenovirus infection of myocardial cells induces an enhanced sensitivity to beta-adrenergic agonists by increasing the concentration of the stimulatory G-protein.
Adrenergic pathways and left ventricular remodeling.
An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice.
Cardiomyopathy induced by cardiac Gs alpha overexpression.
Cellular and molecular alterations in the beta adrenergic system with cardiomyopathy induced by tachycardia.
Increased messenger RNA level of the inhibitory G protein alpha subunit Gi alpha-2 in human end-stage heart failure.
Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy.
Messenger RNA levels of guanine nucleotide-binding proteins are reduced in the ventricle of cardiomyopathic hamsters.
Molecular mechanism of hypertrophied failing heart--abnormalities of the diastolic properties and contractility.
Propranolol prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart failure.
Cardiomyopathy, Dilated
Cardiomyopathy induced by cardiac Gs alpha overexpression.
Detection of mitochondrial dysfunction by EPR technique in mouse model of dilated cardiomyopathy.
Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development.
Improvement of cholera toxin-catalyzed ADP-ribosylation by endogenous ADP-ribosylation factor from bovine brain provides evidence for an unchanged amount of Gs alpha in failing human myocardium.
Increased messenger RNA level of the inhibitory G protein alpha subunit Gi alpha-2 in human end-stage heart failure.
Late-stage alterations in myofibrillar contractile function in a transgenic mouse model of dilated cardiomyopathy (Tgalphaq*44).
TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagCS75Y Cardiomyopathy.
Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways.
Cardiomyopathy, Hypertrophic, Familial
Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy.
Cardiovascular Diseases
Roles of accessory proteins for heterotrimeric g-protein in the development of cardiovascular diseases.
Carney Complex
Sporadic cardiac myxomas and tumors from patients with Carney complex are not associated with activating mutations of the Gs alpha gene.
Cataract
Mutations of RagA GTPase in mTORC1 Pathway Are Associated with Autosomal Dominant Cataracts.
Statins and inflammation in cardiovascular disease.
Cell Transformation, Neoplastic
Identification of functional cooperative mutations of GNAO1 in human acute lymphoblastic leukemia.
Cerebellar Ataxia
Two new cases of anti-Ca (anti-ARHGAP26/GRAF) autoantibody-associated cerebellar ataxia.
Cerebral Infarction
Development of a cell transducible RhoA inhibitor TAT-C3 transferase and its encapsulation in biocompatible microspheres to promote survival and enhance regeneration of severed neurons.
Fuyuan Xingnao Decoction Promotes Angiogenesis Through the Rab1/AT1R Pathway in Diabetes Mellitus Complicated With Cerebral Infarction.
Cervical Intraepithelial Neoplasia
RAP1 GTPase overexpression is associated with cervical intraepithelial neoplasia.
Charcot-Marie-Tooth Disease
A cohort study of MFN2 mutations and phenotypic spectrums in Charcot-Marie-Tooth disease 2A patients.
A novel mitofusin 2 mutation causes canine fetal-onset neuroaxonal dystrophy.
Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin.
Rab7 mutants associated with Charcot-Marie-Tooth disease exhibit enhanced NGF-stimulated signaling.
Cholangiocarcinoma
Hypoxia-mediated miR-212-3p downregulation enhances progression of intrahepatic cholangiocarcinoma through upregulation of Rab1a.
Cholera
A novel guanine nucleotide-binding protein coupled to the alpha 1-adrenergic receptor. II. Purification, characterization, and reconstitution.
A protein kinase C inhibitor, staurosporine, activates phospholipase D via a pertussis toxin-sensitive GTP-binding protein in rabbit peritoneal neutrophils.
Activating mutations of the Gs alpha gene are associated with low levels of Gs alpha protein in growth hormone-secreting tumors.
Activation of ADP-ribosylation factor by Golgi membranes. Evidence for a brefeldin A- and protease-sensitive activating factor on Golgi membranes.
Activation of Escherichia coli heat-labile enterotoxins by native and recombinant adenosine diphosphate-ribosylation factors, 20-kD guanine nucleotide-binding proteins.
Activation of FSH-responsive adenylate cyclase by staurosporine: role for protein phosphorylation in gonadotropin receptor desensitization.
Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity.
Activation of toxin ADP-ribosyltransferases by the family of ADP-ribosylation factors.
ADP-ribosylation factors: a family of approximately 20-kDa guanine nucleotide-binding proteins that activate cholera toxin.
ADP-ribosylation of thylakoid membrane polypeptides by cholera toxin is correlated with inhibition of thylakoid GTPase activity and protein phosphorylation.
ADP-ribosylation of transducin by islet-activation protein. Identification of asparagine as the site of ADP-ribosylation.
ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors.
Age-related changes in G proteins in rat aorta.
Agonist-dependent, cholera toxin-catalyzed ADP-ribosylation of pertussis toxin-sensitive G-proteins following transfection of the human alpha 2-C10 adrenergic receptor into rat 1 fibroblasts. Evidence for the direct interaction of a single receptor with two pertussis toxin-sensitive G-proteins, Gi2 and Gi3.
Alterations in the stimulatory G protein of the rat liver after partial hepatectomy.
Alterations of adenylyl cyclase-linked G proteins in rat liver during aging.
Altered guanine nucleoside triphosphate binding to transducin by cholera toxin-catalysed ADP-ribosylation.
Amino acid sequence of retinal transducin at the site ADP-ribosylated by cholera toxin.
An antibody directed against residues 100-119 within the alpha-helical domain of Galpha(s) defines a novel contact site for beta-adrenergic receptors.
An in vitro model of thyroid neoplasia: permanently transfected FRTL-5 cells with thyroglobulin promoter-cholera toxin A1 subunit minigene.
Analysis of the T-cell activation signaling pathway mediated by tyrosine kinases, protein kinase C, and Ras protein, which is modulated by intracellular cyclic AMP.
Antisense oligodeoxynucleotides to GS protein alpha-subunit sequence accelerate differentiation of fibroblasts to adipocytes.
Association of a solubilized prostaglandin E2 receptor from renal medulla with a pertussis toxin-reactive guanine nucleotide regulatory protein.
Basolateral to apical transcytosis in polarized cells is indirect and involves BFA and trimeric G protein sensitive passage through the apical endosome.
Biochemical characterization of three stimulatory GTP-binding proteins. The large and small forms of Gs and the olfactory-specific G-protein, Golf.
Biphasic regulation of adenylate cyclase by cholera toxin in neuroblastoma x glioma hybrid cells is due to the activation and subsequent loss of the alpha subunit of the stimulatory GTP binding protein (GS).
Botulinum C2 toxin ADP-ribosylates actin.
cAMP-Independent Activation of the Unfolded Protein Response by Cholera Toxin.
Changes in cAMP formation in mononuclear leukocytes of heart and renal transplant recipients.
Characterization of high affinity GTPase activity correlated to beta-adrenergic receptor stimulation of adenylyl cyclase in rat parotid membranes.
Characterization of the membrane-associated GTPase activity: effects of chemotactic factors and toxins.
Characterization of the plasma membrane bound GTPase from rabbit neutrophils. I. Evidence for an Ni-like protein coupled to the formyl peptide, C5a, and leukotriene B4 chemotaxis receptors.
Characterization of transducin from bovine retinal rod outer segments. Mechanism and effects of cholera toxin-catalyzed ADP-ribosylation.
Cholera toxin action on rabbit corpus luteum membranes: effects on adenylyl cyclase activity and adenosine diphospho-ribosylation of the stimulatory guanine nucleotide-binding regulatory component.
Cholera toxin ADP-ribosylates the islet-activating protein substrate in adipocyte membranes and alters its function.
Cholera toxin does not impair hormonal inhibition of adenylate cyclase and concomitant stimulation of a GTPase in adipocyte membranes.
Cholera toxin impairment of opioid-mediated inhibition of adenylate cyclase in neuroblastoma x glioma hybrid cells is due to a toxin-induced decrease in opioid receptor levels.
Cholera toxin induces cyclic AMP-independent down-regulation of Gs alpha and sensitization of alpha 2-autoreceptors in chick sympathetic neurons.
Cholera toxin mediated regulation of the expression of Gq alpha and G11 alpha GTP binding proteins.
Cholera toxin treatment produces down-regulation of the alpha-subunit of the stimulatory guanine-nucleotide-binding protein (Gs).
Cholera toxin-induced Gs alpha down-regulation in neural tissue: studies on the pineal gland.
Chronic activation of inhibitory delta-opioid receptors cross-regulates the stimulatory adenylate cyclase-coupled prostaglandin E1 receptor system in neuroblastoma x glioma (NG108-15) hybrid cells.
Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice.
Chronic exposure of rat glioma C6 cells to cholera toxin induces loss of the alpha-subunit of the stimulatory guanine nucleotide-binding protein (Gs).
Chronic sympathectomy of canine cardiac ventricles affects Gs-adenylyl cyclase coupling and muscarinic receptor density.
Cloning and characterization of a cDNA coding for the alpha-subunit of a stimulatory G protein from Schistosoma mansoni.
Cloning and characterization of a G protein alpha-subunit-encoding gene from the basidiomycete, Coprinus congregatus.
Cyclic AMP regulation of Gs protein. Thyrotropin and forskolin increase the quantity of stimulatory guanine nucleotide-binding proteins in cultured thyroid follicles.
Decreased beta-adrenoceptor-mediated vasodilation in aorta from aged rats: possible involvement of a stimulatory GTP-binding protein.
Decreased incorporation of the photoaffinity probe 8N3-[gamma-32P]-GTP into a 45kD protein in lung tumors.
Deletion within the amino-terminal region of Gs alpha impairs its ability to interact with beta gamma subunits and to activate adenylate cyclase.
Determination of the turn-off reaction for the epinephrine-inhibited human platelet adenylate cyclase.
Developmental differences in the expression of the cholera toxin sensitive subunit (Gs alpha) of adenylate cyclase in the rat small intestine.
Developmental regulation of calmodulin-dependent adenylate cyclase activity in an insect endocrine gland.
Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Galpha(s) and Galpha(i)/Galpha(o) activation.
Differential expression of guanosine triphosphate binding proteins in men at high and low risk for the future development of alcoholism.
Down-regulation of beta-adrenergic receptors by pindolol in Gs alpha-transfected S49 cyc- murine lymphoma cells.
Down-regulation of protein kinase C by parathyroid hormone and mezerein differentially modulates cAMP production and phosphate transport in opossum kidney cells.
Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium.
Effects of cholera toxin on the coupling of thyrotropin-releasing hormone to a guanine nucleotide-binding protein in cultured GH3 cells.
Effects of phospholipid and GTP on recombinant ADP-ribosylation factors (ARFs). Molecular basis for differences in requirements for activity of mammalian ARFs.
Endogenous ADP-ribosylation in brain: initial characterization of substrate proteins.
Enhanced cyclic AMP responses in GH3 pituitary cells pretreated with muscarinic receptor agonists.
Enhanced degradation of stimulatory G-protein (Gs alpha) by cholera toxin is mediated by ADP-ribosylation of Gs alpha protein but not by increased cyclic AMP levels.
Enhanced expression of Gi proteins in non-hypertrophic hearts from rats with hypertension-induced by L-NAME treatment.
Enhanced expression of GTP-binding proteins in differentiated U937 monocytic cells: possible involvement of tyrosine kinase and protein kinase C.
Entamoeba invadens contains the components of a classical adrenergic signaling system.
Essential role of GTP in the expression of adenylate cyclase activity after cholera toxin treatment.
Estradiol up-regulates the stimulatory GTP-binding protein expression in the MCF-7 human mammary carcinoma cell line.
Ethanol differentially regulates G proteins in neural cells.
Evidence for a defect in growth hormone-releasing factor signal transduction in the dwarf (dw/dw) rat pituitary.
Evidence for two GTPases activated by thrombin in membranes of human platelets.
Evidence that activation of a common G-protein by receptors for leukotriene B4 and N-formylmethionyl-leucyl-phenylalanine in HL-60 cells occurs by different mechanisms.
Expression and characterization of the long and short splice variants of GS alpha in S49 cyc- cells.
Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase.
Expression of Plasmodium falciparum trimeric G proteins and their involvement in switching to sexual development.
Forskolin potentiation of cholera toxin-stimulated cyclic AMP accumulation in intact C6-2B cells. Evidence for enhanced Gs-C coupling.
Functional alteration of guanine nucleotide binding proteins (Gs and Gi) in psoriatic epidermis.
Functional homology between signal-coupling proteins. Cholera toxin inactivates the GTPase activity of transducin.
Functional modification by cholera-toxin-catalyzed ADP-ribosylation of a guanine-nucleotide-binding regulatory protein serving as the substrate of pertussis toxin.
Functional modifications of transducin induced by cholera or pertussis-toxin-catalyzed ADP-ribosylation.
G protein coupling to M1 and M3 muscarinic receptors in sublingual glands.
G proteins in Aplysia: biochemical characterization and regional and subcellular distribution.
G-protein mRNA levels during adipocyte differentiation.
G-proteins in guinea pig airway smooth muscle: identification and functional involvement.
G-proteins in rat blood vessels--I. Identification.
Gs alpha availability to cholera toxin-catalysed ADP-ribosylation is decreased in membranes of retinoic acid-treated leukemic cell lines HL-60 and THP-1. A posttranslational effect.
Gs alpha is a substrate for mono(ADP-ribosyl)transferase of NG108-15 cells. ADP-ribosylation regulates Gs alpha activity and abundance.
Gs alpha stimulates transcytosis and apical secretion in MDCK cells through cAMP and protein kinase A.
Gs alpha-dependent and -independent desensitisation of prostanoid IP receptor-activated adenylyl cyclase in NG108-15 cells.
GTP binding proteins: a key role in cellular communication.
GTP-binding proteins in luminal and basolateral membranes from pars convoluta and pars recta of rabbit kidney proximal tubule.
Guanine nucleotide dependent formation of a complex between choleragen (cholera toxin) a subunit and bovine brain ADP-ribosylation factor.
Guanine-nucleotide-binding proteins Gi and Gs in fat-cells from normal, hypothyroid and obese human subjects.
Hamster alpha 1B-adrenergic receptor directly activates Gs in the transfected Chinese hamster ovary cells.
Hydrolysis of GTP by the alpha-chain of Gs and other GTP binding proteins.
Identification of a second putative receptor of platelet-activating factor from human polymorphonuclear leukocytes.
Identification of G-proteins in rat parotid gland plasma membranes and granule membranes: presence of distinct components in granule membranes.
Identification of guanine nucleotide binding regulatory proteins in bovine tracheal smooth muscle.
Iloprost-induced translocation of a 23-kDa protein that is recognized by a Gs alpha antiserum.
Immunochemical detection of GTP-binding protein in cephalopod photoreceptors by anti-peptide antibodies.
Impaired growth hormone-releasing hormone signal transduction in the dwarf (dw) rat is independent of a generalized defect in the stimulatory G-protein, Gs alpha.
Improvement of cholera toxin-catalyzed ADP-ribosylation by endogenous ADP-ribosylation factor from bovine brain provides evidence for an unchanged amount of Gs alpha in failing human myocardium.
Inducible RGS2 is a cross-talk regulator for parathyroid hormone signaling in rat osteoblast-like UMR106 cells.
Inhibition of ADP-ribosyltransferase increases synthesis of Gs alpha in neuroblastoma x glioma hybrid cells and reverses iloprost-dependent heterologous loss of fluoride-sensitive adenylate cyclase.
Insulin stimulates a novel GTPase activity in human platelets.
Involvement of a high-affinity GTPase in the inhibitory coupling of striatal muscarinic receptors to adenylate cyclase.
Involvement of calyculin A inhibitable protein phosphatases in the cyclic AMP signal transduction pathway of mouse corticotroph tumour (AtT20) cells.
Involvement of signal transducing GTP-binding proteins in renal artery alpha 1-adrenoceptor mediated smooth muscle contraction.
Islet-activating protein impairs alpha 2-adrenoceptor-mediated inhibitory regulation of human platelet adenylate cyclase.
Light activation of phospholipase A2 in rod outer segments of bovine retina and its modulation by GTP-binding proteins.
Light-regulated biochemical events in invertebrate photoreceptors. 1. Light-activated guanosinetriphosphatase, guanine nucleotide binding, and cholera toxin catalyzed labeling of squid photoreceptor membranes.
Luteinizing hormone/choriogonadotropin-dependent, cholera toxin-catalyzed adenosine 5'-diphosphate (ADP)-ribosylation of the long and short forms of Gs alpha and pertussis toxin-catalyzed ADP-ribosylation of Gi alpha*.
Mechanism of cholera toxin activation by a guanine nucleotide-dependent 19 kDa protein.
Modification of the amounts of G proteins and of the activity of adenylyl cyclase in human benign thyroid tumours.
Molecular aspects of the cellular activities of ADP-ribosylation factors.
Multiple coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz.
Multiple signalling pathways mediate fungal elicitor-induced beta-thujaplicin biosynthesis in Cupressus lusitanica cell cultures.
Muscarinic blockade of beta-adrenoceptor-stimulated adenylyl cyclase: the role of stimulatory and inhibitory guanine-nucleotide binding regulatory proteins (Gs and Gi).
Mutagenesis of the amino-terminal glycine to alanine in Gs alpha subunit alters beta gamma-dependent properties and decreases adenylylcyclase activation.
Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity.
Neutrophil activation by inflammatory microcrystals of monosodium urate monohydrate utilizes pertussis toxin-insensitive and -sensitive pathways.
Nod factors activate both heterotrimeric and monomeric G-proteins in Vigna unguiculata (L.) Walp.
Opiate and dopamine stimulate different GTPase in striatum: evidence for distinct modulatory mechanisms of adenylate cyclase.
Opposite coupling of prostaglandin E receptor EP3C with Gs and G(o). Stimulation of Gs and inhibition of G(o).
Pharmacological and biochemical characterization of dopamine receptors mediating stimulation of a high affinity GTPase in rat striatum.
Plasma hyperosmolality increases G protein and 3',5'-cyclic adenosine monophosphate synthesis in the paraventricular and supraoptic nuclei.
Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni.
Platelet activating factor stimulates a receptor-coupled membrane GTPase in guinea pig eosinophils.
Possible role of both the alpha and beta gamma subunits of the heterotrimeric G protein, Gs, in transcytosis of the polymeric immunoglobulin receptor.
Primary and secondary structure of bovine retinal S antigen (48-kDa protein).
Priming effects of granulocyte-macrophage colony-stimulating factor are coupled to cholera toxin-sensitive guanine nucleotide binding protein in human T lymphocytes.
Properties of a novel GTP-binding protein which is associated with soluble phosphoinositides-specific phospholipase C.
Prostaglandin-stimulated GTP hydrolysis associated with activation of adenylate cyclase in human platelet membranes.
Receptor-mediated ADP-ribosylation of a phospholipase C-stimulating G protein.
Reduction of adenylyl cyclase activity by cholera toxin in myeloid cells. Long-term down-regulation of Gs alpha subunits by cholera toxin treatment.
Regulation of G-proteins in differentiation. Altered ratio of alpha- to beta-subunits in 3T3-L1 cells.
Regulation of transforming growth factor beta 1 action by multiple transducing pathways: evidence for both G protein-dependent and -independent signaling.
Release of Gs alpha from rabbit intestinal cells following ADP-ribosylation by cholera toxin.
Requirement of phosphatidylinositol 3-kinase activity for bradykinin stimulation of NF-kappaB activation in cultured human epithelial cells.
Role of G protein beta gamma subunits in the regulation of the plasma membrane Ca2+ pump.
Role of guanine nucleotide regulatory proteins and inositol phosphates in the hormone induced mobilization of hepatocyte calcium.
Role of guanine nucleotides in the stimulation of thyroid adenylate cyclase by prostaglandin E1 and cholera toxin.
Segregation of discrete GS alpha-mediated responses that accompany homologous or heterologous desensitization in two related somatic hybrids.
Selective interactions of mu-opioid receptors with pertussis toxin-sensitive G proteins: involvement of the third intracellular loop and the c-terminal tail in coupling.
Sensitization enhances the adenylyl cyclase responsiveness in alveolar macrophages. Changes induced at post-receptor level.
Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs.
Slow oscillations of free intracellular calcium ion concentration in human fibroblasts responding to mechanical stretch.
Solubilization of the vasopressin receptor from rat liver plasma membranes. Evidence for a receptor X GTP-binding protein complex.
Stimulation of high-affinity GTPase activity and cholera toxin-catalysed [32P]ADP-ribosylation of Gi by lysophosphatidic acid (LPA) in wild-type and alpha 2C10 adrenoceptor-transfected Rat 1 fibroblasts.
Stimulation of rat parietal cell function by histamine and GLP-1-(7-36) amide is mediated by Gs alpha.
Stimulatory and inhibitory guanine-nucleotide-binding regulatory protein involvement in stimulation of arachidonic-acid release by N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor from guinea-pig alveolar macrophages. Differential receptor/G-protein interaction assessed by pertussis and cholera toxins.
Stimulus deprivation increases pineal Gs alpha and G beta.
Structural and functional relationships of guanosine triphosphate binding proteins.
Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein.
Temporal evaluation of commitment to sexual development in Plasmodium falciparum.
The bioactive phospholipid, lysophosphatidylcholine, induces cellular effects via G-protein-dependent activation of adenylyl cyclase.
The effect of cholera toxin on the inhibition of vasopressin-stimulated inositol phospholipid hydrolysis is a cyclic AMP-mediated event at the level of receptor binding.
The glutamate-receptor linked cGMP cascade of retinal on-bipolar cells is pertussis and cholera toxin-sensitive.
The inhibition of adenylyl cyclase activity in isolated lung membranes by muscarinic and alpha-adrenoceptor agonists: role of G-protein alpha and beta gamma sub-units.
The presence of a heterotrimeric G protein and its role in signal transduction of extracellular calmodulin in pollen germination and tube growth
Thrombin stimulates pertussis toxin-sensitive and -insensitive GTPase activities and ADP-ribosylation of G(i) in human neuroblastoma SH-EP.
Thrombin, unlike vasopressin, appears to stimulate two distinct guanine nucleotide regulatory proteins in human platelets.
Tissue and species distribution of mRNA encoding two ADP-ribosylation factors, 20-kDa guanine nucleotide binding proteins.
Tissue inhibitor of metalloproteinase-2 stimulates fibroblast proliferation via a cAMP-dependent mechanism.
Transducin and the cyclic GMP phosphodiesterase: amplifier proteins in vision.
Transient and steady state kinetics of the interaction of guanyl nucleotides with the adenylyl cyclase system from rat liver plasma membranes. Interpretation in terms of a simple two-state model.
Translocation of alpha subunits of stimulatory guanine nucleotide-binding proteins through stimulation of the prostacyclin receptor in mouse mastocytoma cells.
Vesicular transport is not required for the cytoplasmic pool of cholera toxin to interact with the stimulatory alpha subunit of the heterotrimeric g protein.
Widespread distribution of Gq alpha/G11 alpha detected immunologically by an antipeptide antiserum directed against the predicted C-terminal decapeptide.
[Effects of G-Protein Regulators and Stylar S-RNase on the Growth and Ca(2+) Concentration of Pyrus pyrifolia Pollen Tube.]
[Inhibition of transducin by lithium: electrophysiological demonstration using the isolated retina]
[The effect of G protein regulator on pollen germination and [Ca2+]i variation in Pyrus serotina Rehd. pollen.]
Choroidal Neovascularization
Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularization.
Rap1 GTPase Activation and Barrier Enhancement in RPE Inhibits Choroidal Neovascularization In Vivo.
Choroideremia
Mouse genetic corneal disease resulting from transgenic insertional mutagenesis.
Chronic Periodontitis
Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.
Ciliary Motility Disorders
Novel Mutation in Retinitis Pigmentosa GTPase Regulator Gene Causes Primary Ciliary Dyskinesia and Retinitis Pigmentosa.
Ciliopathies
A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies.
A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation.
GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119.
Identification of a novel ARL13B variant in a Joubert syndrome-affected patient with retinal impairment and obesity.
Retinal remodeling.
Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina: insights into X-linked Retinitis Pigmentosa and associated ciliopathies.
RPGR isoform imbalance causes ciliary defects due to exon ORF15 mutations in X-linked retinitis pigmentosa (XLRP).
The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.
Classical Swine Fever
Guanylate-binding protein 1, an interferon-induced GTPase, exerts an antiviral activity against classical swine fever virus depending on its GTPase activity.
Rab1A is required for assembly of classical swine fever virus particle.
Viral strategies for triggering and manipulating mitophagy.
Cleft Lip
Identification of a novel heterozygous truncation mutation in exon 1 of ARHGAP29 in an Indian subject with nonsyndromic cleft lip with cleft palate.
Cleft Palate
Identification of a novel heterozygous truncation mutation in exon 1 of ARHGAP29 in an Indian subject with nonsyndromic cleft lip with cleft palate.
Clonorchiasis
[Protective immunity of Cs-Rho GtPase recombinant protein against Clonorchis sinensis infection]
Cluster Headache
A study of adaptive responses in cell signaling in migraine and cluster headache: correlations between headache type and changes in gene expression.
Cockayne Syndrome
The mei3 region of the Schizosaccharomyces pombe genome.
Coinfection
A combinatorial G protein-coupled receptor reconstitution system on budded baculovirus. Evidence for Galpha and Galphao coupling to a human leukotriene B4 receptor.
Colitis
Central role of gimap5 in maintaining peripheral tolerance and T cell homeostasis in the gut.
Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer.
Gimap5-dependent inactivation of GSK3? is required for CD4
IFN-inducible GTPases in host cell defense.
Impaired TGF-beta responses in peripheral T cells of G alpha i2-/- mice.
Long-term treatment with anti-alpha 4 integrin antibodies aggravates colitis in G alpha i2-deficient mice.
Regression of Peyer's patches in G alpha i2 deficient mice prior to colitis is associated with reduced expression of Bcl-2 and increased apoptosis.
Rig-I-/- mice develop colitis associated with downregulation of G alpha i2.
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Therapeutic targeting of alpha 4-integrins in chronic inflammatory diseases: tipping the scales of risk towards benefit?
Colitis, Ulcerative
Emerging views of mitophagy in immunity and autoimmune diseases.
How autophagy controls the intestinal epithelial barrier.
Long-term treatment with anti-alpha 4 integrin antibodies aggravates colitis in G alpha i2-deficient mice.
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Single Nucleotide Polymorphisms That Increase Expression of the Guanosine Triphosphatase RAC1 Are Associated With Ulcerative Colitis.
Colonic Neoplasms
A hallmark of immunoreceptor, the tyrosine-based inhibitory motif ITIM, is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism.
Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis.
Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells.
KRAS Cold Turkey: Using microRNAs to target KRAS-addicted cancer.
Quantitative Proteomics Analysis of Berberine-Treated Colon Cancer Cells Reveals Potential Therapy Targets.
Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression.
Subcellular localization of the Galphai3 protein and G alpha interacting protein, two proteins involved in the control of macroautophagy in human colon cancer HT-29 cells.
The mitochondrial permeability transition regulates cytochrome c release for apoptosis during endoplasmic reticulum stress by remodeling the cristae junction.
Valine-286 residue in the third intracellular loop of the cholecystokinin 2 receptor exerts a pivotal role in cholecystokinin 2 receptor mediated intracellular signal transduction in human colon cancer cells.
[A ?-catenin/IQGAP1 regulatory feedback loop and its effects on the proliferation of colon cancer cells].
Color Vision Defects
A naturally occurring mouse model of achromatopsia: characterization of the mutation in cone transducin and subsequent retinal phenotype.
Cone cGMP-gated channel mutations and clinical findings in patients with achromatopsia, macular degeneration, and other hereditary cone diseases.
Identification of a zebrafish cone photoreceptor-specific promoter and genetic rescue of achromatopsia in the nof mutant.
Mapping of a novel locus for achromatopsia (ACHM4) to 1p and identification of a germline mutation in the alpha subunit of cone transducin (GNAT2).
Colorectal Neoplasms
A novel mechanism underlying phytate-mediated biological action-phytate hydrolysates induce intracellular calcium signaling by a Galphaq protein-coupled receptor and phospholipase C-dependent mechanism in colorectal cancer cells.
Aberrant expression of Rab1A and its prognostic significance in human colorectal cancer.
Clinical value and potential association of Rab1A and FoxM1 aberrant expression in colorectal cancer.
CRMP5-associated GTPase (CRAG) Is a Candidate Driver Gene for Colorectal Cancer Carcinogenesis.
Differential expression of Rac1 identifies its target genes and its contribution to progression of colorectal cancer.
Effects of RAL signal transduction in KRAS- and BRAF-mutated cells and prognostic potential of the RAL signature in colorectal cancer.
ENO1 Acts as a Prognostic Biomarker Candidate and Promotes Tumor Growth and Migration Ability Through the Regulation of Rab1A in Colorectal Cancer.
Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer.
Expression analysis and implication of Rab1A in gastrointestinal relevant tumor.
How autophagy controls the intestinal epithelial barrier.
Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells.
MicroRNA-31 Activates the RAS Pathway and Functions as an Oncogenic MicroRNA in Human Colorectal Cancer by Repressing RAS p21 GTPase Activating Protein 1 (RASA1).
mTORC1 gRABs the Golgi.
Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane.
Rab1A is an mTORC1 activator and a colorectal oncogene.
Rab1A promotes cell proliferation and migration by upregulating Gli1 in colorectal cancer.
Rab1A promotes proliferation and migration abilities via regulation of the HER2/AKT-independent mTOR/S6K1 pathway in colorectal cancer.
RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer.
The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism.
Wild?type blocking pcr coupled with internal competitive amplified fragment improved the detection of rare mutation of KRAS.
Cone Dystrophy
Cone dystrophy phenotype associated with a frameshift mutation (M280fsX291) in the alpha-subunit of cone specific transducin (GNAT2).
Exon screening of the genes encoding the beta- and gamma-subunits of cone transducin in patients with inherited retinal disease.
Cone-Rod Dystrophies
Cone cGMP-gated channel mutations and clinical findings in patients with achromatopsia, macular degeneration, and other hereditary cone diseases.
Exon screening of the genes encoding the beta- and gamma-subunits of cone transducin in patients with inherited retinal disease.
Multimodal imaging of an RPGR carrier female.
Phenotypic variation and genotype-phenotype discordance in canine cone-rod dystrophy with an RPGRIP1 mutation.
Successful gene therapy in the RPGRIP1-deficient dog, a large model of cone-rod dystrophy.
Congenital Abnormalities
The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis.
Congenital Disorders of Glycosylation
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
COVID-19
ACE2 Expression is Increased in the Lungs of Patients with Comorbidities Associated with Severe COVID-19.
Crohn Disease
Abnormal Activation of Autophagy-Induced Crinophagy in Paneth Cells From Patients With Crohn's Disease.
Among autophagy genes, ATG16L1 but not IRGM is associated with Crohn's disease in Iranians.
Correlation between IRGM genetic polymorphisms and Crohn's disease risk: a meta-analysis of case-control studies.
Crohn's disease IRGM risk alleles are associated with altered gene expression in human tissues.
CUBAP: an interactive web portal for analyzing codon usage biases across populations.
Emerging views of mitophagy in immunity and autoimmune diseases.
Etiology of Crohn's disease: many roads lead to autophagy.
Genetic Polymorphisms in Autophagy-Associated Genes in Korean Children With Early-Onset Crohn Disease.
How autophagy controls the intestinal epithelial barrier.
Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.
Inflammatory bowel disease: dysfunction of autophagy?
IRGM rs13361189 polymorphism may contribute to susceptibility to Crohn's disease: A meta-analysis.
Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling.
Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation.
Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Cushing Syndrome
Activating mutation in the stimulatory guanine nucleotide-binding protein in an infant with Cushing's syndrome and nodular adrenal hyperplasia.
Presence of a Gs alpha mutation in an adrenal tumor expressing LH/hCG receptors and clinically associated with Cushing's syndrome.
Cutis Laxa
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Cystic Fibrosis
A recombinant polypeptide model of the second nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator functions as an active ATPase, GTPase and adenylate kinase.
G protein G alpha i-2 inhibits outwardly rectifying chloride channels in human airway epithelial cells.
How autophagy controls the intestinal epithelial barrier.
Inhibition of ATPase, GTPase and adenylate kinase activities of the second nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator by genistein.
Cysts
Definitive evidence using enucleated cytoplasts for a nongenomic basis for the cystic change in endoplasmic reticulum structure caused by STAT5a/b siRNAs.
Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts.
Non-genomic STAT5-dependent effects at the endoplasmic reticulum and Golgi apparatus and STAT6-GFP in mitochondria.
Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening.
Rac Regulates Giardia lamblia Encystation by Coordinating Cyst Wall Protein Trafficking and Secretion.
Ric-8A, an activator protein of G?i, controls mammalian epithelial cell polarity for tight junction assembly and cystogenesis.
Somatic support cells regulate germ cell survival through the Baz/aPKC/Par6 complex.
The Role of Pnut and its Functional Domains in Drosophila Spermatogenesis.
Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation.
Tulp3 Regulates Renal Cystogenesis by Trafficking of Cystoproteins to Cilia.
Deafness
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.
Ebi/AP-1 suppresses pro-apoptotic genes expression and permits long-term survival of Drosophila sensory neurons.
Gene screening facilitates diagnosis of complicated symptoms: A case report.
Molecular analysis of TBL1Y, a Y-linked homologue of TBL1X related with X-linked late-onset sensorineural deafness.
Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form.
Decompression Sickness
Cryo-EM of the dynamin polymer assembled on lipid membrane.
Dementia
On the stability of messenger RNA and ribosomal RNA in the brains of control human subjects and patients with Alzheimer's disease.
Demyelinating Diseases
Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis.
Dengue
Rab 5 is required for the cellular entry of dengue and West Nile viruses.
Viral strategies for triggering and manipulating mitophagy.
Dermatitis, Atopic
Upregulation of the transcript level of GTPase activating protein KIAA0603 in T cells from patients with atopic dermatitis.
Diabetes Mellitus
Expression of the heterotrimeric G protein Gi and ATP release are impaired in erythrocytes of humans with diabetes mellitus.
Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level.
Rac1 Modulates Endothelial Function and Platelet Aggregation in Diabetes Mellitus.
Renal gene expression in embryonic and newborn diabetic mice.
Diabetes Mellitus, Type 1
GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy.
Diabetes Mellitus, Type 2
Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis.
Muscle Rad expression and human metabolism: potential role of the novel Ras-related GTPase in energy expenditure and body composition.
Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level.
Tissue-specific alterations in G protein expression in genetic versus diet-induced models of non-insulin-dependent diabetes mellitus in the mouse.
Diabetic Nephropathies
RhoA/Rho-kinase contribute to the pathogenesis of diabetic renal disease.
Diabetic Retinopathy
The Regulatory Role of Rac1, a Small Molecular Weight GTPase, in the Development of Diabetic Retinopathy.
Diphtheria
A recombinant fusion toxin targeted to the granulocyte-macrophage colony-stimulating factor receptor.
A screening procedure for the intracellular expression of native proteins by Saccharomyces cerevisiae: discrimination of diphtheria toxin-resistant mutants.
Active-site mutations of the diphtheria toxin catalytic domain: role of histidine-21 in nicotinamide adenine dinucleotide binding and ADP-ribosylation of elongation factor 2.
ADP-ribosylated elongation factor 2 (ADP-ribosyl-EF-2) is unable to promote translocation within the ribosome.
ADP-ribosylation of elongation factor 2 by diphtheria toxin. Isolation and properties of the novel ribosyl-amino acid and its hydrolysis products.
ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyl-diphthamide and its hydrolysis products.
Autoradiographic assay of mutants resistant to diphtheria toxin in mammalian cells in vitro.
Bacterial protein toxins acting on intracellular targets.
Biosynthesis of diphthamide in Saccharomyces cerevisiae. Partial purification and characterization of a specific S-adenosylmethionine:elongation factor 2 methyltransferase.
Biosynthetic labeling of diphthamide in Saccharomyces cerevisiae.
Botulinum C2 toxin ADP-ribosylates actin.
Characteristics of guinea-pig immune sera elicited by a synthetic diphtheria toxin oligopeptide.
Characterization of a transgenic mouse line lacking photoreceptor development within the ventral retina.
Characterization of Ca2+/calmodulin-dependent protein kinase in rat pancreatic islets.
Complete nucleotide sequence and characterization of the 5'-flanking region of mammalian elongation factor 2 gene.
Crystallization of diphtheria toxin.
Design of highly specific cytotoxins by using trans-splicing ribozymes.
Differential toxicity of ricin and diphtheria toxin for bloodstream forms of Trypanosoma brucei.
Diphtheria toxin and its ADP-ribosyltransferase-defective homologue CRM197 possess deoxyribonuclease activity.
Diphtheria toxin as a molecular tool in the study of acidic fibroblast growth factor signalling.
Diphtheria toxin does not enter resistant cells by receptor-mediated endocytosis.
Diphtheria toxin NAD affinity and ADP ribosyltransferase activity are reduced at tryptophan 153 substitutions for alanine or phenylalanine.
Diphtheria toxin prevents catecholamine desensitization of A431 human epidermoid carcinoma cells.
Diphtheria toxin-related cytokine fusion proteins: elongation factor 2 as a target for the treatment of neoplastic disease.
Diphtheria toxin-resistant mutants of Saccharomyces cerevisiae.
Diphtheria toxin. Site and configuration of ADP-ribosylation of diphthamide in elongation factor 2.
Endogenous ADP-ribosylation for eukaryotic elongation factor 2: evidence of two different sites and reactions.
Enzymatically active peptide from the adenosine diphosphate-ribosylating toxin of Pseudomonas aeruginosa.
Eukaryotic elongation factor 2 loses its non-specific affinity for RNA and leaves polyribosomes as a result of ADP-ribosylation.
Eukaryotic elongation factor-2 (eEF-2) activity in bovine mammary tissue in relation to milk protein synthesis.
Evidence of endogenous mono-ADP-ribosylation of cardiac proteins via anti-ADP-ribosylarginine immunoreactivity.
Expression of functional diphtheria toxin receptors on highly toxin-sensitive mouse cells that specifically bind radioiodinated toxin.
Expression of non-ADP-ribosylatable, diphtheria toxin-resistant elongation factor 2 in Saccharomyces cerevisiae.
Gene for the diphtheria toxin-susceptible elongation factor 2 from Methanococcus vannielii.
Genetic analysis of the cell surface: association of human chromosome 5 with sensitivity to diphtheria toxin in mouse-human somatic cell hybrids.
Human antibodies neutralizing diphtheria toxin in vitro and in vivo.
Immunotoxins in cancer therapy: Review and update.
In vitro biosynthesis of diphthamide, studied with mutant Chinese hamster ovary cells resistant to diphtheria toxin.
In vitro-translated diphtheria toxin A chain inhibits translation in wheat germ extracts: analysis of biologically active, caspase-3-resistant diphtheria toxin mutants.
Induction of diphtheria toxin-resistant cells by mutagen-carcinogens.
Interaction of diphtheria toxin fragment A and of elongation factor 2 with cibacron blue.
Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein.
Introduction of additional charges as an aid in protein purification: isolation of elongation factor 2 from Sulfolobus acidocaldarius by preparative isoelectric focusing before and after ADP-ribosylation.
Is sporadic Alzheimer's disease associated with diphtheria toxin?
Isolation and distribution of elongation factor 2 in eggs and embryos of sea urchins.
Isolation and properties of the trypsin-derived ADP-ribosyl peptide from diphtheria toxin-modified yeast elongation factor 2.
Kinetics of adenosinediphosphoribosylation of elongation factor 2 in cells exposed to diphtheria toxin.
Modulation of the intracellular stability and toxicity of diphtheria toxin through degradation by the N-end rule pathway.
Molecular cloning and expression of gene fragments from corynebacteriophage beta encoding enzymatically active peptides of diphtheria toxin.
Molecular, functional and structural properties of an archaebacterial elongation factor 2.
Mutations in the elongation factor 2 gene which confer resistance to diphtheria toxin and Pseudomonas exotoxin A. Genetic and biochemical analyses.
Nucleotide binding to elongation factor 2 inactivated by diphtheria toxin.
Pasteurella multocida toxin as a transporter of non-cell-permeating proteins.
Posttranslational modification of elongation factor 2 in diphtheria-toxin-resistant mutants of CHO-K1 cells.
Preparation and properties of chimeric toxins prepared from the constituent polypeptides of diphtheria toxin and ricin. Evidence for entry of ricin A-chain via the diphtheria toxin pathway.
Primary structure at the site in beef and wheat elongation factor 2 of ADP-ribosylation by diphtheria toxin.
Primary structure of elongation factor 2 around the site of ADP-ribosylation is highly conserved from archaebacteria to eukaryotes.
Pseudomonas aeruginosa exoenzyme S: an adenosine diphosphate ribosyltransferase distinct from toxin A.
Purification and properties of an altered form of elongation factor 2 from mutant cells resistant to intoxication by diphtheria toxin.
Purification of a nitric oxide-stimulated ADP-ribosylated protein using biotinylated beta-nicotinamide adenine dinucleotide.
Purification of elongation factor 2 from human placenta and evidence of its fragmentation patterns in various eukaryotic sources.
Recognition of elongation factor 2 by diphtheria toxin is not solely defined by the presence of diphthamide.
Reconstitution of active diphtheria toxin based on a hexahistidine tagged version of the B-fragment produced to high yields in bacteria.
Requirement for prolonged action in the cytosol for optimal protein synthesis inhibition by diphtheria toxin.
Ribosyl-diphthamide: confirmation of structure by fast atom bombardment mass spectrometry.
Saccharomyces cerevisiae elongation factor 2. Mutagenesis of the histidine precursor of diphthamide yields a functional protein that is resistant to diphtheria toxin.
Specific purification of elongation factor 2 and isolation of its antibody.
Targeted introduction of a diphtheria toxin resistant mutation into the chromosomal EF-2 locus of Pichia pastoris and expression of immunotoxin in the EF-2 mutants.
Targeting diphtheria toxin to growth factor receptors.
The Father, Son and Cholix Toxin: The Third Member of the DT Group Mono-ADP-Ribosyltransferase Toxin Family.
The frequency of mutants in human fibroblasts UV-irradiated at various times during S-phase suggests that genes for thioguanine- and diphtheria toxin-resistance are replicated early.
The mechanism of ADP-ribosylation of elongation factor 2 catalyzed by fragment A from diphtheria toxin.
Translocation of diphtheria toxin to the cytosol and formation of cation selective channels.
Use of synthetic peptides and site-specific antibodies to localize a diphtheria toxin sequence associated with ADP-ribosyltransferase activity.
Distemper
Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity.
Drug Resistant Epilepsy
Pathogenic DNM1 Gene Variant Presenting With Unusually Nonsevere Neurodevelopmental Phenotype: A Case Report.
Dwarfism
Brachytic 1 of barley (Hordeum vulgare L.) encodes the ? subunit of heterotrimeric G protein.
Function and expression pattern of the alpha subunit of the heterotrimeric G protein in rice.
Heterotrimeric G protein alpha subunit is involved in rice brassinosteroid response.
Rice transgenic plants with suppressed expression of the ? subunit of the heterotrimeric G protein.
Suppression of the heterotrimeric G protein causes abnormal morphology, including dwarfism, in rice.
Dysentery, Amebic
Heterotrimeric G-protein signaling is critical to pathogenic processes in Entamoeba histolytica.
Dyskinesias
D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways.
RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum.
Encephalitis
Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis.
Encephalitis, Japanese
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Encephalomyelitis
Immune-related GTPase Irgm1 exacerbates experimental auto-immune encephalomyelitis by promoting the disruption of blood-brain barrier and blood-cerebrospinal fluid barrier.
Over-expression of GTP-binding proteins and GTPase activity in mouse astrocyte membranes in response to Theiler's murine encephalomyelitis virus infection.
Ulk1 Governs Nerve Growth Factor/TrkA Signaling by Mediating Rab5 GTPase Activation in Porcine Hemagglutinating Encephalomyelitis Virus-Induced Neurodegenerative Disorders.
Endometrial Hyperplasia
Autophagy in the physiological endometrium and cancer.
Endometrial Neoplasms
Autophagy in the physiological endometrium and cancer.
NMU signaling promotes endometrial cancer cell progression by modulating adhesion signaling.
Endometriosis
Hepatocyte nuclear factor (HNF)-1? and its physiological importance in endometriosis.
Endotoxemia
The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia.
Epilepsies, Myoclonic
Generalized myoclonic epilepsy with photosensitivity in juvenile dogs caused by a defective DIRAS family GTPase 1.
Epilepsy
Altered Expression of the Small Guanosine Triphosphatase RhoA in Human Temporal Lobe Epilepsy.
Epilepsy, Temporal Lobe
Altered Expression of the Small Guanosine Triphosphatase RhoA in Human Temporal Lobe Epilepsy.
Esophageal Neoplasms
Aberrant methylation of the Ras-related associated with diabetes gene in human primary esophageal cancer.
Comprehensive multi-omics analysis identified core molecular processes in esophageal cancer and revealed GNGT2 as a potential prognostic marker.
Essential Hypertension
No evidence for involvement of alleles of the 825-C/T polymorphism of the G-protein subunit beta 3 in body weight regulation.
Selectively enhanced cellular signaling by Gi proteins in essential hypertension. G alpha i2, G alpha i3, G beta 1, and G beta 2 are not mutated.
Exanthema
Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins.
Eye Diseases
The interplay between RPGR, PDE? and Arl2/3 regulate the ciliary targeting of farnesylated cargo.
Fatty Liver
Hepatic Deficiency in Transcriptional Cofactor TBL1 Promotes Liver Steatosis and Hypertriglyceridemia.
Variants in the autophagy-related gene IRGM confer susceptibility to non-alcoholic fatty liver disease by modulating lipophagy.
Fibrosarcoma
Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
Fibrous Dysplasia of Bone
An activating Gs alpha mutation is present in fibrous dysplasia of bone in the McCune-Albright syndrome.
Endocrine manifestations of stimulatory G protein alpha-subunit mutations and the role of genomic imprinting.
Gs(alpha) mutations and imprinting defects in human disease.
Juxta-articular myxoma and intramuscular myxoma are two distinct entities. Activating Gs alpha mutation at Arg 201 codon does not occur in juxta-articular myxoma.
Minireview: GNAS: normal and abnormal functions.
The histopathology of fibrous dysplasia of bone in patients with activating mutations of the Gs alpha gene: site-specific patterns and recurrent histological hallmarks.
Fibrous Dysplasia, Monostotic
Increased proliferation of osteoblastic cells expressing the activating Gs alpha mutation in monostotic and polyostotic fibrous dysplasia.
Fibrous Dysplasia, Polyostotic
A Case of McCune-Albright Syndrome Associated with Gs alpha Mutation in the Bone Tissue.
ACTH-independent massive bilateral adrenal disease (AIMBAD): a subtype of Cushing's syndrome with major diagnostic and therapeutic implications.
Activating GNAS mutations in parosteal osteosarcoma.
Activating mutation in the stimulatory guanine nucleotide-binding protein in an infant with Cushing's syndrome and nodular adrenal hyperplasia.
Activating mutation of GS alpha in McCune-Albright syndrome causes skin pigmentation by tyrosinase gene activation on affected melanocytes.
Activating mutations of the stimulatory G protein in the McCune-Albright syndrome.
An activating Gs alpha mutation is present in fibrous dysplasia of bone in the McCune-Albright syndrome.
Endocrine manifestations of stimulatory G protein alpha-subunit mutations and the role of genomic imprinting.
Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation.
G protein oncogenes in pituitary tumors.
Genetic and molecular aspects of McCune-Albright syndrome.
Growth hormone-prolactin-thyrotropin-secreting pituitary adenoma in atypical McCune-Albright syndrome with functionally normal Gs alpha protein.
Gs alpha mutation at codon 201 in pituitary adenoma causing gigantism in a 6-year-old boy with McCune-Albright syndrome.
Gs(alpha) mutations and imprinting defects in human disease.
Identification of a second-site suppressor mutation of the GTPase defect associated with McCune-Albright syndrome: a model using the yeast heterotrimeric G protein, GPA1.
Increased expression of the c-fos proto-oncogene in bone from patients with fibrous dysplasia.
Increased proliferation of osteoblastic cells expressing the activating Gs alpha mutation in monostotic and polyostotic fibrous dysplasia.
Juxta-articular myxoma and intramuscular myxoma are two distinct entities. Activating Gs alpha mutation at Arg 201 codon does not occur in juxta-articular myxoma.
Minireview: GNAS: normal and abnormal functions.
Odontogenic myxomas are not associated with activating mutations of the Gs alpha gene.
Ovarian dysfunction by activating mutation of GS alpha: McCune-Albright syndrome as a model.
Sporadic cardiac myxomas and tumors from patients with Carney complex are not associated with activating mutations of the Gs alpha gene.
The histopathology of fibrous dysplasia of bone in patients with activating mutations of the Gs alpha gene: site-specific patterns and recurrent histological hallmarks.
Thyroid carcinoma in the McCune-Albright syndrome: contributory role of activating Gs alpha mutations.
Urinary cyclic adenosine 3',5'-monophosphate response in McCune-Albright syndrome: clinical evidence for altered renal adenylate cyclase activity.
Fragile X Syndrome
Prepulse inhibition in Drosophila melanogaster larvae.
Frontotemporal Lobar Degeneration
SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis.
Gallstones
A new heterozygous mutation (D196N) in the Gs alpha gene as a cause for pseudohypoparathyroidism type IA in a boy who had gallstones.
Gastrinoma
Gs alpha--identification of a gene highly expressed by insulinoma and other endocrine tumors.
Gastroenteritis
Viral strategies for triggering and manipulating mitophagy.
Gastrointestinal Neoplasms
Expression analysis and implication of Rab1A in gastrointestinal relevant tumor.
Molecular mutation characteristics of mismatch and homologous recombination repair genes in gastrointestinal cancer.
Genetic Diseases, Inborn
Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP/PKA signaling defects in the Drosophila melanogaster neurofibromatosis-1 growth deficiency.
Genetic basis of human reproductive endocrine disorders.
Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy.
Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization.
The Rheb family of GTP-binding proteins.
Gigantism
Gs alpha mutation at codon 201 in pituitary adenoma causing gigantism in a 6-year-old boy with McCune-Albright syndrome.
Glaucoma
Evidence for RPGRIP1 gene as risk factor for primary open angle glaucoma.
Research progress on human genes involved in the pathogenesis of glaucoma (Review).
Glaucoma, Open-Angle
Evidence for RPGRIP1 gene as risk factor for primary open angle glaucoma.
Glioblastoma
Aberrant splicing of Gs alpha transcript in transformed human astroglial and glioblastoma cell lines.
Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFR?-stimulated glioma tumorigenesis in mice and humans.
ADP-Ribosylation Factor Like GTPase 4C (ARL4C) augments stem-like traits of glioblastoma cells by upregulating ALDH1A3.
An Arf/Rab cascade controls the growth and invasiveness of glioblastoma.
Analysis of microarray data for identification of key microRNA signatures in glioblastoma multiforme.
Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion.
Efficient proliferation and mitosis of glioblastoma cells infected with human cytomegalovirus is mediated by RhoA GTPase.
Glioblastoma motility occurs in the absence of actin polymer.
In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion.
Nuclear translocation of fibroblast growth factor-2 (FGF2) is regulated by Karyopherin-?2 and Ran GTPase in human glioblastoma cells.
Glioma
ADP-Ribosylation Factor Like GTPase 4C (ARL4C) augments stem-like traits of glioblastoma cells by upregulating ALDH1A3.
Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates.
Bradykinin stimulates GTP hydrolysis in NG108-15 membranes by a high-affinity, pertussis toxin-insensitive GTPase.
Calmodulin-dependent protein kinases in rat glioblastoma.
Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells.
Cholera toxin impairment of opioid-mediated inhibition of adenylate cyclase in neuroblastoma x glioma hybrid cells is due to a toxin-induced decrease in opioid receptor levels.
Cholera toxin mediated regulation of the expression of Gq alpha and G11 alpha GTP binding proteins.
Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2.
Desensitization of opioid-stimulated GTPase in neuroblastoma x glioma hybrid cells.
Differential effects of suramin on the coupling of receptors to individual species of pertussis-toxin-sensitive guanine-nucleotide-binding proteins.
Endogenous regulator of G protein signaling proteins suppress Galphao-dependent, mu-opioid agonist-mediated adenylyl cyclase supersensitization.
Enhanced degradation of stimulatory G-protein (Gs alpha) by cholera toxin is mediated by ADP-ribosylation of Gs alpha protein but not by increased cyclic AMP levels.
Equivalent regulation of wild type and an epitope-tagged variant of Gs alpha by the IP prostanoid receptor following expression in neuroblastoma x glioma hybrid, NG108-15, cells.
Ethanol differentially regulates G proteins in neural cells.
Exosomes derived from microRNA-199a-overexpressing mesenchymal stem cells inhibit glioma progression by down-regulating AGAP2.
Foetal-calf serum stimulates a pertussis-toxin-sensitive high-affinity GTPase activity in rat glioma C6 BU1 cells.
Guanine nucleotide regulation of the pertussis and cholera toxin substrates of rat glioma C6 BU1 cells.
Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma.
High expression of immunity-related GTPase family M protein in glioma promotes cell proliferation and autophagy protein expression.
Identification of the critical domains of the delta-opioid receptor involved in G protein coupling using site-specific synthetic peptides.
Inhibition of ADP-ribosyltransferase increases synthesis of Gs alpha in neuroblastoma x glioma hybrid cells and reverses iloprost-dependent heterologous loss of fluoride-sensitive adenylate cyclase.
IRGM promotes glioma M2 macrophage polarization through p62/TRAF6/NF-?B pathway mediated IL-8 production.
Irgm1 knockout indirectly inhibits regeneration after skeletal muscle injury in mice.
Is current therapy of malignant gliomas beneficial for patients? Proteomics evidence of shifts in glioma cells expression patterns under clinically relevant treatment conditions.
Knockdown of Rab21 inhibits proliferation and induces apoptosis in human glioma cells.
LncRNA DANCR functions as a competing endogenous RNA to regulate RAB1A expression by sponging miR-634 in glioma.
MiR-1202 functions as a tumor suppressor in glioma cells by targeting Rab1A.
Modulation of sodium-sensitive GTPase by partial opiate agonists. An explanation for the dual requirement for Na+ and GTP in inhibitory regulation of adenylate cyclase.
Opiates inhibit adenylate cyclase by stimulating GTP hydrolysis.
Persistent activation of the alpha subunit of Gs promotes its removal from the plasma membrane.
Probing the infiltrating character of brain tumors: inhibition of RhoA/ROK-mediated CD44 cell surface shedding from glioma cells by the green tea catechin EGCg.
Prostaglandin E1-mediated, cyclic AMP-independent, down-regulation of Gs alpha in neuroblastoma x glioma hybrid cells.
Quantitative stoichiometry of the proteins of the stimulatory arm of the adenylyl cyclase cascade in neuroblastoma x glioma hybrid, NG108-15 cells.
RAB1A regulates glioma cellular proliferation and invasion via the mTOR signaling pathway and epithelial-mesenchymal transition.
Reconstitution of high-affinity opioid agonist binding in brain membranes.
Role of calmodulin-dependent phosphorylation of elongation factor 2 in the proliferation of rat glial cells.
Secretion of protease nexin-1 by C6 glioma cells is under the control of a heterotrimeric G protein, Go1.
SEPT7 overexpression inhibits glioma cell migration by targeting the actin cytoskeleton pathway.
The gap junction protein Cx43 regulates B-lymphocyte spreading and adhesion.
The small GTPase Rac1 is involved in the maintenance of stemness and malignancies in glioma stem-like cells.
Tubulin stimulates adenylyl cyclase activity in rat striatal membranes via transfer of guanine nucleotide to Gs protein.
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioblastoma cell chemotaxis via Lyn activation.
Glomerulonephritis, Membranous
Both Peripheral Blood and Urinary miR-195-5p, miR-192-3p, miR-328-5p and Their Target Genes PPM1A, RAB1A and BRSK1 May Be Potential Biomarkers for Membranous Nephropathy.
Glucose Intolerance
The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice.
glutamate-5-semialdehyde dehydrogenase deficiency
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Goiter
Activating thyrotropin receptor mutations are present in nonadenomatous hyperfunctioning nodules of toxic or autonomous multinodular goiter.
Constitutive activation of the Gs alpha protein-adenylate cyclase pathway may not be sufficient to generate toxic thyroid adenomas.
Identification of constitutively activating somatic thyrotropin receptor mutations in a subset of toxic multinodular goiters.
Point mutations of ras and Gs alpha subunit genes in thyroid tumors.
The thyrotropin receptor (TSH-R) is not an oncogene for thyroid tumors: structural studies of the TSH-R and the alpha-subunit of Gs in human thyroid neoplasms.
Gonorrhea
The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target.
Graft vs Host Disease
Immunotoxins in cancer therapy: Review and update.
Reciprocal function of Galphai2 and Galphai3 in graft-versus-host disease.
Granulomatous Disease, Chronic
The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
Granulosa Cell Tumor
Analysis of mutations in genes of the follicle-stimulating hormone receptor signaling pathway in ovarian granulosa cell tumors.
Growth Hormone-Secreting Pituitary Adenoma
Analysis of the Gs alpha gene in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues.
Glycoprotein hormone alpha-subunit production in somatotroph adenomas with and without Gs alpha mutations.
Gs alpha overexpression and loss of Gs alpha imprinting in human somatotroph adenomas: association with tumor size and response to pharmacologic treatment.
Heterozygous gsp mutation renders ion channels of human somatotroph adenoma cells unresponsive to growth hormone-releasing hormone.
Low prevalence of Gs alpha mutations in śomatotroph adenomas of children and adolescents.
Pronostic and therapeutic consequences of Gs alpha mutations in somatotroph adenomas.
Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction-primer-introduced restriction analysis.
[Etiopathogenesis of pituitary tumors]
[Pathophysiology and gene abnormalities of endocrine tumors]
Hearing Loss
Ebi/AP-1 suppresses pro-apoptotic genes expression and permits long-term survival of Drosophila sensory neurons.
Hearing Loss, Sensorineural
Congenital isolated central hypothyroidism: Novel mutations and their functional implications.
Heart Diseases
A functional polymorphism of the G{alpha}q (GNAQ) gene is associated with accelerated mortality in African-American heart failure.
Heterotrimeric G proteins in heart disease.
MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq.
Heart Failure
A functional polymorphism of the G{alpha}q (GNAQ) gene is associated with accelerated mortality in African-American heart failure.
Activation of G?q in Cardiomyocytes Increases Vps34 Activity and Stimulates Autophagy.
Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion.
Alterations in Ca2+ cycling proteins and G alpha q signaling after left ventricular assist device support in failing human hearts.
Beta-adrenoceptor-G protein-adenylate cyclase complex in rat hearts with ischemic heart failure produced by coronary artery ligation.
Decreased Gs alpha mRNA levels accompany the fall in Gs and adenylyl cyclase activities in compensated left ventricular hypertrophy. In heart failure, only the impairment in adenylyl cyclase activation progresses.
Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice.
Diverse G protein and beta-adrenergic receptor mRNA expression in normal and failing porcine hearts.
Enhanced exercise capacity in mice with severe heart failure treated with an allosteric effector of hemoglobin, myo-inositol trispyrophosphate.
Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure.
Expression of Gi-2 alpha and Gs alpha in myofibroblasts localized to the infarct scar in heart failure due to myocardial infarction.
G proteins and heart failure: is Galphaq a novel target for heart failure?
Improvement of cholera toxin-catalyzed ADP-ribosylation by endogenous ADP-ribosylation factor from bovine brain provides evidence for an unchanged amount of Gs alpha in failing human myocardium.
Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy.
Markedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure.
Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction.
MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq.
Potential Treatment of Cardiac Hypertrophy and Heart Failure by Inhibiting the Sarcolemmal Binding of Phospholipase Cbeta1b.
Propranolol prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart failure.
Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy.
Reversible heart failure in G alpha(q) transgenic mice.
Signalling pathways in cardiac failure.
Subcellular compartmentalization of Gs alpha in cardiac myocytes and its redistribution in heart failure.
[Molecular mechanism underlying the development of heart failure mediated by heterotrimeric G protein signaling]
Hemangioma
Recurrent GNAQ mutations in anastomosing hemangiomas.
Hemangioma, Cavernous, Central Nervous System
Cloning of the murine Krit1 cDNA reveals novel mammalian 5' coding exons.
KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis.
Hematologic Neoplasms
GTPase regulator associated with the focal adhesion kinase (GRAF) transcript was down-regulated in patients with myeloid malignancies.
Hemorrhagic Fever, Crimean
The interferon response circuit in antiviral host defense.
Hepatitis B
GTPase activity is not essential for the interferon-inducible MxA protein to inhibit the replication of hepatitis B virus.
Hepatitis C
A single nucleotide polymorphism in activated cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients.
Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M.
IQGAP2 is a novel interferon-alpha antiviral effector gene acting non-conventionally through the NF-?B pathway.
Supporting Role for GTPase Rab27a in Hepatitis C Virus RNA Replication through a Novel miR-122-Mediated Effect.
The Inflammasome Components NLRP3 and ASC Act in Concert with IRGM To Rearrange the Golgi Apparatus during Hepatitis C Virus Infection.
Hepatitis E
Identification of the interferon-inducible GTPase GBP1 as major restriction factor for the Hepatitis E virus.
Hereditary Sensory and Motor Neuropathy
Early onset severe and late-onset mild Charcot-Marie-Tooth disease with mitofusin 2 (MFN2) mutations.
Herpes Simplex
Dynasore disrupts trafficking of herpes simplex virus proteins.
Herpes Simplex Virus Type 1 Neuronal Infection Perturbs Golgi Apparatus Integrity through Activation of Src Tyrosine Kinase and Dyn-2 GTPase.
MiR-199a Inhibits Secondary Envelopment of Herpes Simplex Virus-1 Through the Downregulation of Cdc42-specific GTPase Activating Protein Localized in Golgi Apparatus.
Viral strategies for triggering and manipulating mitophagy.
Herpesviridae Infections
Human MxB Protein Is a Pan-herpesvirus Restriction Factor.
heterotrimeric g-protein gtpase deficiency
Accelerated transition from the double-positive to single-positive thymocytes in G alpha i2-deficient mice.
Conditional, tissue-specific expression of Q205L G alpha i2 in vivo mimics insulin action.
Crystal structure of Rnd3/RhoE: functional implications.
Heterogeneous mutations in the gene encoding the alpha-subunit of the stimulatory G protein of adenylyl cyclase in Albright hereditary osteodystrophy.
Human platelet Galphaq deficiency is associated with decreased Galphaq gene expression in platelets but not neutrophils.
Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation.
Immunochemical analysis of the alpha-subunit of the stimulatory G-protein of adenylyl cyclase in patients with Albright's hereditary osteodystrophy.
Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency.
Induction of Galphaq-specific antisense RNA in vivo causes increased body mass and hyperadiposity.
Mutations in exon 7 of the GTP-binding protein Gs alpha were not a common cause of pseudohypoparathyroidism with Albright's hereditary osteodystrophy in Japanese.
Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity.
RAC2 GTPase deficiency and myeloid cell dysfunction in human and mouse.
Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo.
Histiocytoma, Malignant Fibrous
Proteomic signatures corresponding to histological classification and grading of soft-tissue sarcomas.
Huntington Disease
Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease.
Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity.
Rab11 as a modulator of synaptic transmission.
Hyperparathyroidism, Primary
Parathyroid-targeted overexpression of Regulator of G-Protein Signaling 5 (R GS5) causes hyperparathyroidism in transgenic mice.
Hypersensitivity
GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy.
Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence.
The RHO1-specific GTPase-activating protein LRG1 regulates polar tip growth in parallel to Ndr kinase signaling in Neurospora.
Hypertension
Deletion of STAT5a/b in vascular smooth muscle abrogates the male bias in hypoxic pulmonary hypertension in mice: implications in the human disease.
Enhanced expression of Gi proteins in non-hypertrophic hearts from rats with hypertension-induced by L-NAME treatment.
Polymorphisms in the RAC1 gene are associated with hypertension risk factors in a Chilean pediatric population.
Role of Rho in Salt-Sensitive Hypertension.
Structural and functional analysis of the regulator of g protein signaling 2-g?q complex.
Hypertension, Portal
GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension.
Hyperthyroidism
McCune-Albright syndrome associated with non-autoimmune type of hyperthyroidism with development of thyrotoxic crisis.
Membrane-Bound and cytosolic forms of heterotrimeric G proteins in young and adult rat myocardium: influence of neonatal hypo- and hyperthyroidism.
Oncogenic potential of a mutant human thyrotropin receptor expressed in FRTL-5 cells.
Thyroid status affects the rat cardiac beta-adrenoceptor system transiently and time-dependently.
Hypertrophy, Left Ventricular
Decreased Gs alpha mRNA levels accompany the fall in Gs and adenylyl cyclase activities in compensated left ventricular hypertrophy. In heart failure, only the impairment in adenylyl cyclase activation progresses.
RGS4 reduces contractile dysfunction and hypertrophic gene induction in Galpha q overexpressing mice.
Hypobetalipoproteinemias
Insights from human congenital disorders of intestinal lipid metabolism.
Hypocalcemia
Familial Albright's hereditary osteodystrophy with hypoparathyroidism: normal structural Gs alpha gene.
Hypoglycemia
Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency.
Hypogonadism
Gene screening facilitates diagnosis of complicated symptoms: A case report.
Hypokalemic Periodic Paralysis
Autonomously functioning thyroid nodule associated with thyrotoxic periodic paralysis.
Hypoparathyroidism
Familial Albright's hereditary osteodystrophy with hypoparathyroidism: normal structural Gs alpha gene.
Hypothyroidism
Congenital isolated central hypothyroidism: Novel mutations and their functional implications.
Membrane-Bound and cytosolic forms of heterotrimeric G proteins in young and adult rat myocardium: influence of neonatal hypo- and hyperthyroidism.
Ileal Diseases
Clinical and Genetic Risk Factors for Perianal Crohn's Disease in a Population-Based Cohort.
Infections
A role for endoplasmic reticulum exit sites (ERES) in foot-and-mouth disease virus infection.
Activation of Ran GTPase by a Legionella Effector Promotes Microtubule Polymerization, Pathogen Vacuole Motility and Infection.
Adenovirus infection of myocardial cells induces an enhanced sensitivity to beta-adrenergic agonists by increasing the concentration of the stimulatory G-protein.
Association of autophagy-related IRGM polymorphisms with latent versus active tuberculosis infection in a Chinese population.
Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity.
Bacterial cytotoxins: targeting eukaryotic switches.
Brucella melitensis, B. neotomae and B. ovis elicit common and distinctive macrophage defense transcriptional responses.
Caveolin-1-dependent infectious entry of human papillomavirus type 31 in human keratinocytes proceeds to the endosomal pathway for pH-dependent uncoating.
Chlamydiae host cell interactions revealed using DNA microarrays.
Cholix Toxin, a Novel ADP-ribosylating Factor from Vibrio cholerae.
Cloning of PLD2 from baculovirus for studies in inflammatory responses.
Colletotrichum orbiculare Regulates Cell Cycle G1/S Progression via a Two-Component GAP and a GTPase to Establish Plant Infection.
Comprehensive profiling of EBV gene expression in nasopharyngeal carcinoma through paired-end transcriptome sequencing.
Dissemination of lymphocytic choriomeningitis virus from the gastric mucosa requires G protein-coupled signaling.
Divergent Evolution of Legionella RCC1 Repeat Effectors Defines the Range of Ran GTPase Cycle Targets.
Elevated expression of immunity-related GTPase family M in gastric cancer.
Endosomal maturation, Rab7 GTPase and phosphoinositides in African swine fever virus entry.
ESCRT-0 Component Hrs Promotes Macropinocytosis of Kaposi's Sarcoma-Associated Herpesvirus in Human Dermal Microvascular Endothelial Cells.
Experimental studies on the pathogenesis of infections due to Pseudomonas aeruginosa: direct evidence for toxin production during Pseudomonas infection of burned skin tissues.
Expression profiling of genes involved in the biotrophic colonisation of Coffea arabica leaves by Hemileia vastatrix
Functional IRGM polymorphism is associated with language impairment in glioma and upregulates cytokine expressions.
GBP5 Is an Interferon-Induced Inhibitor of Respiratory Syncytial Virus.
Gene expression profile of CD4+ T cells reveals an interferon signaling suppression associated with progression of experimental Schistosoma japonicum infection.
Genetic analysis of Leishmania donovani tropism using a naturally attenuated cutaneous strain.
Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-?B Signaling.
GTPase Activity of MxB Contributes to Its Nuclear Location, Interaction with Nucleoporins and Anti-HIV-1 Activity.
Herpes Simplex Virus Type 1 Neuronal Infection Perturbs Golgi Apparatus Integrity through Activation of Src Tyrosine Kinase and Dyn-2 GTPase.
Host factors associated with the Sindbis virus RNA-dependent RNA polymerase: a role for G3BP1 and G3BP2 in virus replication.
Host interferon-? inducible protein contributes to Brucella survival.
IIGP1, an interferon-gamma-inducible 47-kDa GTPase of the mouse, showing cooperative enzymatic activity and GTP-dependent multimerization.
Immune-related GTPase M (IRGM1) regulates neuronal autophagy in a mouse model of stroke.
Induction of interleukin-11 mediated by RhoA GTPase during human cytomegalovirus lytic infection.
Infection of neuroretinal cells in vitro by avian sarcoma viruses UR1 and UR2: transformation, cell growth stimulation, and changes in transducin levels.
Infectious bursal disease virus uptake involves macropinocytosis and trafficking to early endosomes in a Rab5-dependent manner.
Inhibition of opiate receptor-mediated signal transmission by rabies virus in persistently infected NG-108-15 mouse neuroblastoma-rat glioma hybrid cells.
Intracellular invasion by Orientia tsutsugamushi is mediated by integrin signaling and actin cytoskeleton rearrangements.
IQGAP2 is a novel interferon-alpha antiviral effector gene acting non-conventionally through the NF-?B pathway.
IRGM in autophagy and viral infections.
Irgm1 knockout indirectly inhibits regeneration after skeletal muscle injury in mice.
Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination.
Legionella hijacks the host Golgi-to-ER retrograde pathway for the association of Legionella-containing vacuole with the ER.
Listeria monocytogenes antagonizes the human GTPase Cdc42 to promote bacterial spread.
Loss of the interferon-?-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection.
LvCdc42 is a potential negative regulator of Lvp53 in Litopenaeus vannamei exposed to Vibrio alginolyticus stress.
Mechanism of action of Pseudomonas aeruginosa exotoxin A in experimental mouse infections: adenosine diphosphate ribosylation of elongation factor 2.
Mediation of Interleukin-23 and Tumor Necrosis Factor-Driven Reactive Arthritis by Chlamydia-Infected Macrophages in SKG Mice.
Mx1 of black carp functions importantly in the antiviral innate immune response.
Nitric oxide-mediated intracellular growth restriction of pathogenic Rhodococcus equi can be prevented by iron.
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
Protective role for interferon-beta in coxsackievirus B3 infection.
Proteomics and Functional Analyses of Pepper Abscisic Acid-Responsive 1 (ABR1), Which Is Involved in Cell Death and Defense Signaling.
Pseudomonas fluorescens and Trichoderma asperellum Enhance Expression of G? Subunits of the Pea Heterotrimeric G-protein during Erysiphe pisi Infection.
Quantitative Proteomics Reveals the Dynamics of Protein Phosphorylation in Human Bronchial Epithelial Cells during Internalization, Phagosomal Escape, and Intracellular Replication of Staphylococcus aureus.
Rac GTPases in human diseases.
Rare variant MX1 alleles increase human susceptibility to zoonotic H7N9 influenza virus.
Regulation of Trypanosoma cruzi invasion of nonphagocytic cells by the endocytically active GTPases dynamin, Rab5, and Rab7.
RhoB is a component of the human cytomegalovirus assembly complex and is required for efficient viral production.
RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.
Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.
Short hairpin RNA-mediated inhibition of measles virus replication in vitro.
Small rho GTPases and cholesterol biosynthetic pathway intermediates in African swine fever virus infection.
SPIKE1 Activates the GTPase ROP6 to Guide the Polarized Growth of Infection Threads in Lotus japonicus.
Structure of the UreD-UreF-UreG-UreE complex in Helicobacter pylori: a model study.
Study of vaccinia and cowpox viruses' replication in Rac1-N17 dominant-negative cells.
Temporal SILAC-based quantitative proteomics identifies host factors involved in chikungunya virus replication.
The Salmonella effectors SseF and SseG inhibit Rab1A-mediated autophagy to facilitate intracellular bacterial survival and replication.
The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance.
The IFN-inducible Golgi- and endoplasmic reticulum- associated 47-kDa GTPase IIGP is transiently expressed during listeriosis.
The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway.
The Inflammasome Components NLRP3 and ASC Act in Concert with IRGM To Rearrange the Golgi Apparatus during Hepatitis C Virus Infection.
The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation.
The Rab-binding Profiles of Bacterial Virulence Factors during Infection.
The tig1 histone deacetylase complex regulates infectious growth in the rice blast fungus Magnaporthe oryzae.
The Type IV Secretion System Effector Protein CirA Stimulates the GTPase Activity of RhoA and Is Required for Virulence in a Mouse Model of Coxiella burnetii Infection.
TLR adaptor MyD88 is essential for pathogen control during oral toxoplasma gondii infection but not adaptive immunity induced by a vaccine strain of the parasite.
Transcriptional response of bean bug (Riptortus pedestris) upon infection with entomopathogenic fungus, Beauveria bassiana JEF-007.
Transducin ?-like 1 X-linked receptor 1 (TBLR1) affects RGNNV infection through negative regulation of interferon immune response in orange-spotted grouper, Epinephelus coioides.
Ulk1 Governs Nerve Growth Factor/TrkA Signaling by Mediating Rab5 GTPase Activation in Porcine Hemagglutinating Encephalomyelitis Virus-Induced Neurodegenerative Disorders.
[Protective immunity of Cs-Rho GtPase recombinant protein against Clonorchis sinensis infection]
Infertility
Characterization of a fission yeast gene, gpa2, that encodes a G alpha subunit involved in the monitoring of nutrition.
Infertility, Male
Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction.
Inflammatory Bowel Diseases
Association between variants of the autophagy related gene--IRGM and susceptibility to Crohn's disease and ulcerative colitis: a meta-analysis.
Emerging views of mitophagy in immunity and autoimmune diseases.
How autophagy controls the intestinal epithelial barrier.
Insufficient evidence for association of NOD2/CARD15 or other inflammatory bowel disease-associated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantation.
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients.
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Inflammatory Breast Neoplasms
A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype.
Biology and management of inflammatory breast cancer.
Caveolin-1 Mediates Inflammatory Breast Cancer Cell Invasion via the Akt1 Pathway and RhoC GTPase.
Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling.
Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer.
Regulation of inflammatory breast cancer cell invasion through Akt1/PKB? phosphorylation of RhoC GTPase.
RhoC GTPase Is a Potent Regulator of Glutamine Metabolism and N-Acetylaspartate Production in Inflammatory Breast Cancer Cells.
RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype.
WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer.
Influenza, Human
A Comprehensive Review on the Interaction Between the Host GTPase Rab11 and Influenza A Virus.
Chemical-controlled Activation of Antiviral Myxovirus Resistance Protein 1.
Comprehensive profiling of EBV gene expression in nasopharyngeal carcinoma through paired-end transcriptome sequencing.
Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity.
Enzymatic characterization of interferon-induced antiviral GTPases murine Mx1 and human MxA proteins.
Influenza Virus Induces Cholesterol-Enriched Endocytic Recycling Compartments for Budozone Formation via Cell Cycle-Independent Centrosome Maturation.
Influenza Virus Susceptibility of Wild-Derived CAST/EiJ Mice Results from Two Amino Acid Changes in the MX1 Restriction Factor.
Interferon-induced Mx proteins in antiviral host defense.
Interferon-inducible mouse Mx1 protein that confers resistance to influenza virus is GTPase.
Mx1 GTPase accumulates in distinct nuclear domains and inhibits influenza A virus in cells that lack promyelocytic leukaemia protein nuclear bodies.
Mx1 in Hematopoietic Cells Protects against Thogoto Virus Infection.
MxA GTPase: oligomerization and GTP-dependent interaction with viral RNP target structures.
Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein.
Role of GTPase activity of murine Mx1 protein in nuclear localization and anti-influenza virus activity.
Simvastatin modulates cellular components in influenza A virus-infected cells.
Structural basis of oligomerization in the stalk region of dynamin-like MxA.
Switch in antiviral specificity of a GTPase upon translocation from the cytoplasm to the nucleus.
The interferon response circuit in antiviral host defense.
The viral nucleoprotein determines mx sensitivity of influenza a viruses.
Unique ability of pandemic influenza to downregulate the genes involved in neuronal disorders.
Viral strategies for triggering and manipulating mitophagy.
[Mechanism underlying the anterograde transport of the influenza A virus transmembrane proteins and genome in host cytoplasm].
Insulin Resistance
Ablation of ALCAT1 Mitigates Hypertrophic Cardiomyopathy through Effects on Oxidative Stress and Mitophagy.
Conditional, tissue-specific expression of Q205L G alpha i2 in vivo mimics insulin action.
Ethanol feeding impairs insulin-stimulated glucose uptake in isolated rat skeletal muscle: role of Gs alpha and cAMP.
Galpha(i2) enhances insulin signaling via suppression of protein-tyrosine phosphatase 1B.
Rac1 muscle knockout exacerbates the detrimental effect of high-fat diet on insulin-stimulated muscle glucose uptake independently of Akt.
Insulinoma
Absence of mutations in the Gs alpha and Gi2 alpha genes in sporadic parathyroid adenomas and insulinomas.
Ca2+ signaling and gene transcription in glucose-stimulated insulinoma cells.
Gs alpha--identification of a gene highly expressed by insulinoma and other endocrine tumors.
Intellectual Disability
A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory.
Central Nervous System Functions of PAK Protein Family: From Spine Morphogenesis to Mental Retardation.
Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD.
Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.
Role of a heterotrimeric G-protein, Gi2, in the corticogenesis: possible involvement in periventricular nodular heterotopia and intellectual disability.
Intervertebral Disc Degeneration
Mitophagy in degenerative joint diseases.
Intestinal Volvulus
Filarial parasites contain a ras homolog of the TC4/ran/Spil family.
Ischemic Stroke
CID1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke.
Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke.
Kidney Neoplasms
Inadequate activation of the GTPase RhoA contributes to the lack of fibronectin matrix assembly in von Hippel-Lindau protein-defective renal cancer cells.
Leptin promotes invasiveness of murine renal cancer cells via extracellular signal-regulated kinases and rho dependent pathway.
Learning Disabilities
The segregation of different submicroscopic imbalances underlying the clinical variability associated with a familial karyotypically balanced translocation.
Leber Congenital Amaurosis
Leber congenital amaurosis caused by an RPGRIP1 mutation shows treatment potential.
Phenotypic variation and genotype-phenotype discordance in canine cone-rod dystrophy with an RPGRIP1 mutation.
The RPGRIP1-related retinal phenotype in children.
Legionnaires' Disease
Divergent Evolution of Legionella RCC1 Repeat Effectors Defines the Range of Ran GTPase Cycle Targets.
Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination.
Structure of the GTPase and GDI domains of FeoB, the ferrous iron transporter of Legionella pneumophila.
The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b.
Leiomyosarcoma
Proteomic signatures corresponding to histological classification and grading of soft-tissue sarcomas.
Leprosy
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.
Leukemia
A GTPase-activating protein binds STAT3 and is required for IL-6-induced STAT3 activation and for differentiation of a leukemic cell line.
A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein.
Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells.
Existence of multiple novel Gs alpha splice variants in acute leukemia patients.
Functionally nonequivalent interactions of guanosine 5'-triphosphate, inosine 5'-triphosphate, and xanthosine 5'-triphosphate with the retinal G-protein, transducin, and with Gi-proteins in HL-60 leukemia cell membranes.
Generation of SUMO-1 modified proteins in E. coli: towards understanding the biochemistry/structural biology of the SUMO-1 pathway.
Immunotoxins in cancer therapy: Review and update.
Improvement of cholera toxin-catalyzed ADP-ribosylation by endogenous ADP-ribosylation factor from bovine brain provides evidence for an unchanged amount of Gs alpha in failing human myocardium.
Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies.
Leukemic potential of doubly mutant Nf1 and Wv hematopoietic cells.
Mitofusin-2 mediates doxorubicin sensitivity and acute resistance in Jurkat leukemia cells.
Pleiotropic role of Rac in mast cell activation revealed by a cell permeable Bordetella dermonecrotic fusion toxin.
PLEKHG2 promotes heterotrimeric G protein ??-stimulated lymphocyte migration via Rac and Cdc42 activation and actin polymerization.
Retinoic acid-mediated decrease of G (alpha S) protein expression: involvement of G (alpha S) in the differentiation of HL-60 myeloid cells.
The GTPase domain of Galphao contributes to the functional interaction of Galphao with the promyelocytic leukemia zinc finger protein.
The N-terminal domain of the non-receptor tyrosine kinase ABL confers protein instability and suppresses tumorigenesis.
Leukemia, Erythroblastic, Acute
Differential expression of Ran GTPase during HMBA-induced differentiation in murine erythroleukemia cells.
Early growth response transcription factor EGR-1 regulates Galphaq gene in megakaryocytic cells.
Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases.
Induction of erythroid differentiation by altered Galpha16 activity as detected by a reporter gene assay in MB-02 cells.
Phorbol 12-myristate 13-acetate (PMA) responsive sequence in Galphaq promoter during megakaryocytic differentiation. Regulation by EGR-1 and MAP kinase pathway.
The P2U purinoceptor obligatorily engages the heterotrimeric G protein G16 to mobilize intracellular Ca2+ in human erythroleukemia cells.
Leukemia, Hairy Cell
Immunotoxins in cancer therapy: Review and update.
Leukemia, Lymphocytic, Chronic, B-Cell
Immunotoxins in cancer therapy: Review and update.
Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia.
Rho and Rap guanosine triphosphatase signaling in B cells and chronic lymphocytic leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Analysis of mutations and expression of GAP-related domain of the neurofibromatosis type 1 (NF1) gene in the progression of chronic myelogenous leukemia.
Bone marrow-derived mesenchymal stromal cells promote resistance to tyrosine kinase inhibitors in chronic myeloid leukemia via the IL-7/JAK1/STAT5 pathway.
Concomitant presence of JAK2V617F mutation and BCR?ABL translocation in two patients: A new entity or a variant of myeloproliferative neoplasms (Case report).
Detection of Chromosomal Translocation in Hematologic Malignancies by a Novel DNA-Based Looped Ligation Assay (LOLA).
New alternative splicing BCR/ABL-OOF shows an oncogenic role by lack of inhibition of BCR GTPase activity and an increased of persistence of Rac activation in chronic myeloid leukemia.
p210(Bcr-Abl) desensitizes Cdc42 GTPase signaling for SDF-1alpha-directed migration in chronic myeloid leukemia cells.
RalA, a GTPase targeted by miR?181a, promotes transformation and progression by activating the Ras?related signaling pathway in chronic myelogenous leukemia.
Leukemia, Myeloid
Gs alpha availability to cholera toxin-catalysed ADP-ribosylation is decreased in membranes of retinoic acid-treated leukemic cell lines HL-60 and THP-1. A posttranslational effect.
Leukemia, Myeloid, Acute
Genetic and pharmacologic evidence implicating the p85 alpha, but not p85 beta, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis.
High expression of GTPase regulator associated with the focal adhesion kinase (GRAF) is a favorable prognostic factor in acute myeloid leukemia.
Immunotoxins in cancer therapy: Review and update.
Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death.
Leukemia, Myelomonocytic, Juvenile
Leukemic potential of doubly mutant Nf1 and Wv hematopoietic cells.
Leukemia-Lymphoma, Adult T-Cell
Immunotoxins in cancer therapy: Review and update.
Leukoplakia
Recurrent genomic alterations in sequential progressive leukoplakia and oral cancer: drivers of oral tumorigenesis?
Lipoma
RFLP analysis of human chromosome 11 region q13 in multiple symmetric lipomatosis and multiple endocrine neoplasia type 1-associated lipomas.
Listeriosis
The IFN-inducible Golgi- and endoplasmic reticulum- associated 47-kDa GTPase IIGP is transiently expressed during listeriosis.
Liver Cirrhosis, Biliary
Emerging views of mitophagy in immunity and autoimmune diseases.
Liver Diseases
The immunity-related GTPase M rs13361189 variant does not increase the risk for prevalent or incident steatosis; results from the Framingham Heart Study.
Variants in the autophagy-related gene IRGM confer susceptibility to non-alcoholic fatty liver disease by modulating lipophagy.
Liver Neoplasms
Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A.
DLC-1:a Rho GTPase-activating protein and tumour suppressor.
Dysregulation of GTPase IMAP family members in hepatocellular cancer.
Tensins are versatile regulators of Rho GTPase signalling and cell adhesion.
Low Tension Glaucoma
Evidence for RPGRIP1 gene as risk factor for primary open angle glaucoma.
Lung Injury
G-protein activation and expression in lung injury.
The GTPase Rab1 Is Required for NLRP3 Inflammasome Activation and Inflammatory Lung Injury.
Lung Neoplasms
Aberrant expression of Rab1A and its prognostic significance in human colorectal cancer.
AGO2 promotes tumor progression in KRAS-driven mouse models of non-small cell lung cancer.
ARHGAP6 regulates the proliferation, migration and invasion of lung cancer cells.
Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis.
Caveolin-1 promotes radioresistance via IRGM-regulated autophagy in lung cancer.
Diagnostic and prognostic value of blood samples for KRAS mutation identification in lung cancer: a meta-analysis.
Expression of Rab1A is upregulated in human lung cancer and associated with tumor size and T stage.
Fragile Histidine Triad Mediated Tumor Suppression of Lung Cancer by Targeting Multiple Components of the Ras/Rho GTPase Molecular Switch.
GPR78 promotes lung cancer cell migration and metastasis by activation of G?q-Rho GTPase pathway.
Heterotrimeric G-protein, G?16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer.
In Silico Screening of Mutated K-Ras Inhibitors from Malaysian Typhonium flagelliforme for Non-Small Cell Lung Cancer.
Inhibitory heterotrimeric GTP-binding proteins inhibit hydrogen peroxide-induced apoptosis by up-regulation of Bcl-2 via NF-kappaB in H1299 human lung cancer cells.
Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer.
MicroRNA?4500 suppresses tumor progression in non?small cell lung cancer by regulating STAT3.
MiR-124a Regulates Extracellular Vesicle Release by Targeting GTPase Rabs in Lung Cancer.
Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display.
Prognostic value of KRAS/TP53/PIK3CA in non-small cell lung cancer.
Rab8 GTPase regulates Klotho-mediated inhibition of cell growth and progression by directly modulating its surface expression in human non-small cell lung cancer.
Ran GTPase induces EMT and enhances invasion in non-small cell lung cancer cells through activation of PI3K-AKT pathway.
Stimulatory heterotrimeric G protein augments gamma ray-induced apoptosis by up-regulation of Bak expression via CREB and AP-1 in H1299 human lung cancer cells.
Suppression of Tobacco Carcinogen-Induced Lung Tumorigenesis by Aerosol-Delivered Glycerol Propoxylate Triacrylate-Spermine Copolymer/Short Hairpin Rab25 RNA Complexes in Female A/J Mice.
Targeted delivery of Rab26 siRNA with precisely tailored DNA prism for lung cancer therapy.
The RAS-related GTPase RHOB confers resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer via an AKT-dependent mechanism.
Lupus Erythematosus, Systemic
Emerging views of mitophagy in immunity and autoimmune diseases.
Podocytes and autophagy: a potential therapeutic target in lupus nephritis.
Lupus Nephritis
Podocytes and autophagy: a potential therapeutic target in lupus nephritis.
Lymphatic Metastasis
Aberrant expression of Rab1A and its prognostic significance in human colorectal cancer.
Expression of Rab1A in bladder cancer and its clinical implications.
Pooled analysis of prognostic value and clinical significance of Rab1A expression in human solid tumors.
Rab1A promotes cell proliferation and migration by upregulating Gli1 in colorectal cancer.
Reduced RhoA expression enhances breast cancer metastasis with a concomitant increase in CCR5 and CXCR4 chemokines signaling.
RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck.
Lymphoma
A novel Gs alpha mutant in a patient with Albright hereditary osteodystrophy uncouples cell surface receptors from adenylyl cyclase.
A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma.
Activated Gs alpha but not Gi alpha prevents the thermal inactivation of adenylyl cyclase in plasma membranes derived from S49 lymphoma cells.
Adenylate cyclase inhibition and GTPase stimulation by somatostatin in S49 lymphoma cyc- variants are prevented by islet-activating protein.
Altered Pattern of Immunoglobulin Hypermutation in Mice Deficient in Slip-GC Protein.
Cardiac adenylyl cyclase, beta-adrenergic receptors, and G proteins in salt-sensitive hypertension.
Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice.
Coronary artery stenosis in rats affects beta-adrenergic receptor signaling in myocytes.
Decreased incorporation of the photoaffinity probe 8N3-[gamma-32P]-GTP into a 45kD protein in lung tumors.
Development and Clinical Utility of a Blood-Based Test Service for the Rapid Identification of Actionable Mutations in Non-Small Cell Lung Carcinoma.
Effect of (211)At alpha-particle irradiation on expression of selected radiation responsive genes in human lymphocytes.
Effect of ethanol treatment on the activity and amount of stimulatory GTP-binding regulatory protein (Gs) in S49 murine lymphoma cells and human erythrocytes.
Expression and characterization of the long and short splice variants of GS alpha in S49 cyc- cells.
Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase.
Expression of the Rho-family GTPase gene RHOF in lymphocyte subsets and malignant lymphomas.
Hematopoietic recovery after IEV chemotherapy for malignant lymphoma followed by different cytokines can be monitored by analysis of Galpha 16 and CD34.
Identification and characterization of the 35-kDa beta subunit of guanine-nucleotide-binding proteins by an antiserum raised against transducin.
Immunoelectron microscopic identification of cytoplasmic and nuclear Gs alpha in S49 lymphoma cells.
Improvement of cholera toxin-catalyzed ADP-ribosylation by endogenous ADP-ribosylation factor from bovine brain provides evidence for an unchanged amount of Gs alpha in failing human myocardium.
Mechanisms of autoregulation of C3G, activator of the GTPase Rap1, and its catalytic deregulation in lymphomas.
Novel Therapeutic Targets in Non-small Cell Lung Cancer.
Pertussis toxin inhibition of B cell and macrophage responses to bacterial lipopolysaccharide.
Prognostic significance of Tiam1 expression in papillary thyroid carcinoma.
RHOA mutations in peripheral T cell lymphoma.
Somatostatin-induced stimulation of a high-affinity GTPase in membranes of S49 lymphoma cyc- and H21a variants.
Speckled-like pattern in the germinal center (SLIP-GC): A nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells.
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Treatment in hypertensive cardiac hypertrophy, II. Postreceptor events.
Vaccinia virus systems for expression of G alpha genes in S49 cells.
Lymphoma, B-Cell
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Transducin ?-like protein 1 controls multiple oncogenic networks in diffuse large B-cell lymphoma.
Lymphoma, Follicular
Detection of Chromosomal Translocation in Hematologic Malignancies by a Novel DNA-Based Looped Ligation Assay (LOLA).
Oncogenic Rag GTPase signaling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR.
Lymphoma, Large B-Cell, Diffuse
Transducin ?-like protein 1 controls multiple oncogenic networks in diffuse large B-cell lymphoma.
Lymphoma, T-Cell
A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma.
Roles of GTP and Rho GTPases in pancreatic islet beta cell function and dysfunction.
The inhibition of the effect and mechanism of vascular intimal hyperplasia in Tiam1 knockout mice.
The Tiam1 Guanine Nucleotide Exchange Factor is Auto-inhibited by its Pleckstrin Homology Coiled-Coil Extension Domain.
The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.
Timing of Novel Drug 1A-116 to Circadian Rhythms Improves Therapeutic Effects against Glioblastoma.
Lymphopenia
GIMAP5 Deficiency Is Associated with Increased AKT Activity in T Lymphocytes.
Sequence variation and expression of the Gimap gene family in the BB rat.
Macular Degeneration
Cone cGMP-gated channel mutations and clinical findings in patients with achromatopsia, macular degeneration, and other hereditary cone diseases.
Exon screening of the genes encoding the beta- and gamma-subunits of cone transducin in patients with inherited retinal disease.
Magnesium Deficiency
Severe dietary magnesium deficiency does not alter levels and function of myocardial Gs alpha and Gi alpha.
Malaria
Effects of interruption of apicoplast function on malaria infection, development, and transmission.
Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria.
Plasmodium falciparum ARFGAP: expression and crystallization of the catalytic domain.
Thiostrepton binds to malarial plastid rRNA.
Mandibulofacial Dysostosis
Haploinsufficiency of a spliceosomal GTPase encoded by EFTUD2 causes mandibulofacial dysostosis with microcephaly.
Mandibulofacial dysostosis with microcephaly: An expansion of the phenotype via parental survey.
Novel Splice Site Pathogenic Variant of EFTUD2 Is Associated with Mandibulofacial Dysostosis with Microcephaly and Extracranial Symptoms in Korea.
Mania
Lithium administered by eye drops: a better treatment for bipolar affective disorder?
Mastocytoma
Translocation of alpha subunits of stimulatory guanine nucleotide-binding proteins through stimulation of the prostacyclin receptor in mouse mastocytoma cells.
Mastocytosis, Systemic
Genetic and pharmacologic evidence implicating the p85 alpha, but not p85 beta, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis.
Measles
Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity.
Enzymatic characterization of interferon-induced antiviral GTPases murine Mx1 and human MxA proteins.
Rab9 GTPase is required for replication of human immunodeficiency virus type 1, filoviruses, and measles virus.
Viral strategies for triggering and manipulating mitophagy.
Medulloblastoma
Disruption of the ciliary GTPase Arl13b suppresses Sonic hedgehog overactivation and inhibits medulloblastoma formation.
Role of Rac1-regulated signaling in medulloblastoma invasion. Laboratory investigation.
Megalencephaly
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Melanoma
Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion.
ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathway.
Autoantibodies to transducin in a patient with melanoma-associated retinopathy.
Cancer-retina antigens -- a new group of tumor antigens.
CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma.
cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells.
Characterization of human melanoma cell lines and melanocytes by proteome analysis.
Clinical and pathological associations of the activating RAC1 P29S mutation in primary cutaneous melanoma.
Deletion analogues of transportan.
Emerging views of mitophagy in immunity and autoimmune diseases.
Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi.
IFNg-induced Irgm1 promotes tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy.
In vivo Effects in Melanoma of ROCK Inhibition-Induced FasL Overexpression.
Inhibition of the RhoA GTPase Activity Increases Sensitivity of Melanoma Cells to UV Radiation Effects.
IRGM promotes melanoma cell survival through autophagy and is a promising prognostic biomarker for clinical application.
IRGM1 enhances B16 melanoma cell metastasis through PI3K-Rac1 mediated epithelial mesenchymal transition.
Irgm1 knockout indirectly inhibits regeneration after skeletal muscle injury in mice.
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
Mutational profile of GNAQQ209 in human tumors.
Novel somatic mutations in heterotrimeric G proteins in melanoma.
Oncogenic G Protein GNAQ Induces Uveal Melanoma and Intravasation in Mice.
Photoreceptor proteins as cancer-retina antigens.
Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis.
Preventing the activation or cycling of the Rap1 GTPase alters adhesion and cytoskeletal dynamics and blocks metastatic melanoma cell extravasation into the lungs.
Pseudomonas aeruginosa ExoT induces G1 cell cycle arrest in melanoma cells.
RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes.
Rac activation and inactivation control plasticity of tumor cell movement.
RAC1 and Melanoma.
RAC1mutation is not a predictive biomarker for PI3'-kinase-?-selective pathway-targeted therapy.
RAC1P29S is a spontaneously activating cancer-associated GTPase.
Ral activation promotes melanomagenesis.
Ran GTPase is an independent prognostic marker in malignant melanoma which promotes tumour cell migration and invasion.
Retraction Note to: cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca2+ homeostasis in melanoma cells.
Ric-8A gene deletion or phorbol ester suppresses tumorigenesis in a mouse model of GNAQ(Q209L)-driven melanoma.
Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions.
Targeting NRAS in melanoma.
Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas.
Targeting TBK1 Inhibits Migration and Resistance to MEK Inhibitors in Mutant NRAS Melanoma.
The involvement of mutant Rac1 in the formation of invadopodia in cultured melanoma cells.
The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
The Small GTPase ARF6 Stimulates ?-Catenin Transcriptional Activity During WNT5A-Mediated Melanoma Invasion and Metastasis.
Upregulation of intratumoral HLA class I and peritumoral Mx1 in ulcerated melanomas.
Visible light modulates the expression of cancer-retina antigens.
Meningioma
Reduced expression of neurofibromin in human meningiomas.
Meningitis, Bacterial
Human guanylate binding protein-1 is a secreted GTPase present in increased concentrations in the cerebrospinal fluid of patients with bacterial meningitis.
Menkes Kinky Hair Syndrome
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Mesothelioma
Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.
Metabolic Diseases
RRAD inhibits aerobic glycolysis, invasion, and migration and is associated with poor prognosis in hepatocellular carcinoma.
Microcephaly
Haploinsufficiency of a spliceosomal GTPase encoded by EFTUD2 causes mandibulofacial dysostosis with microcephaly.
Mandibulofacial dysostosis with microcephaly: An expansion of the phenotype via parental survey.
Novel Splice Site Pathogenic Variant of EFTUD2 Is Associated with Mandibulofacial Dysostosis with Microcephaly and Extracranial Symptoms in Korea.
Migraine Disorders
A study of adaptive responses in cell signaling in migraine and cluster headache: correlations between headache type and changes in gene expression.
Mitochondrial Diseases
The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases.
Mouth Neoplasms
Heterotrimeric G-protein alpha-12 (G?12) subunit promotes oral cancer metastasis.
Urinary-type plasminogen activator receptor (uPAR) modulates oral cancer cell behavior with alteration in p130cas.
Multiple Endocrine Neoplasia
A pituitary specific point mutation of codon 201 of the Gs alpha gene in a pituitary adenoma of a patient with multiple endocrine neoplasia (MEN) type 1.
Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations.
Gs alpha mutation may be uncommon in patients with multiple endocrine neoplasia type 1.
Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction-primer-introduced restriction analysis.
Study of the multiple endocrine neoplasia type 1, growth hormone-releasing hormone receptor, Gs alpha, and Gi2 alpha genes in isolated familial acromegaly.
Multiple Endocrine Neoplasia Type 1
Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations.
Gs alpha mutation may be uncommon in patients with multiple endocrine neoplasia type 1.
Study of the multiple endocrine neoplasia type 1, growth hormone-releasing hormone receptor, Gs alpha, and Gi2 alpha genes in isolated familial acromegaly.
Multiple Endocrine Neoplasia Type 2b
Relatively good prognosis of multiple endocrine neoplasia type 2B in Japanese: review of cases in Japan and analysis of genetic changes in tumors.
Multiple Myeloma
DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway.
IQGAP1 plays an important role in the cell proliferation of multiple myeloma via the MAP kinase (ERK) pathway.
Quercetin suppresses the proliferation of multiple myeloma cells by down-regulating IQ motif-containing GTPase activating protein 1 expression and extracellular signal-regulated kinase activation.
Truncated protein tyrosine phosphatase receptor type O suppresses AKT signaling through IQ motif containing GTPase activating protein 1 and confers sensitivity to bortezomib in multiple myeloma.
Muscle Cramp
Antimicrobial peptide CRAMP (16-33) stalls bacterial cytokinesis by inhibiting FtsZ assembly.
Muscle Hypotonia
Impaired turnover of hyperfused mitochondria in severe axonal neuropathy due to a novel DRP1 mutation.
Muscle Spasticity
Homotypic fusion of ER membranes requires the dynamin-like GTPase atlastin.
Muscular Atrophy
Characterization of control and immobilized skeletal muscle: an overview from genetic engineering.
Protein synthesis in skeletal muscle of neonatal pigs is enhanced by administration of ?-hydroxy-?-methylbutyrate.
Muscular Diseases
Dynamin 2 mutations associated with human diseases impair clathrin-mediated receptor endocytosis.
Muscular Dystrophies
Analyses of beta-1 syntrophin, syndecan 2 and gem GTPase as candidates for chicken muscular dystrophy.
Increase in the amount of elongation factor 2 in chicken muscular dystrophy.
Sparks, signals and shock absorbers: how dystrophin loss causes muscular dystrophy.
Muscular Dystrophy, Duchenne
Muscular dystrophy in the Japanese Spitz: an inversion disrupts the DMD and RPGR genes.
Mycoses
CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex.
Myelodysplastic Syndromes
Aberrant methylation of GTPase regulator associated with the focal adhesion kinase (GRAF) promoter is an adverse prognostic factor in myelodysplastic syndrome.
Abnormal methylation of GRAF promoter Chinese patients with acute myeloid leukemia.
Assessment of growth and differentiation processes in myelodysplastic syndromes by PCR analysis of Galpha16 and 5'-lipoxygenase.
Screening of mutations in the additional sex combs like 1, transcriptional regulator, tumor protein p53, and KRAS proto-oncogene, GTPase/NRAS proto-oncogene, GTPase genes of patients with myelodysplastic syndrome.
Myocardial Infarction
Dietary magnesium deficiency increases Gi alpha levels in the rat heart after myocardial infarction.
Dynamic changes in G alpha i-2 levels in rat hearts associated with impaired heart function after myocardial infarction.
Expression of Gi-2 alpha and Gs alpha in myofibroblasts localized to the infarct scar in heart failure due to myocardial infarction.
Impaired platelet function reduces myocardial infarct size in Galphaq knock-out mice in vivo.
Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress.
Myocardial Ischemia
Regional myocardial downregulation of the inhibitory guanosine triphosphate-binding protein (Gi alpha 2) and beta-adrenergic receptors in a porcine model of chronic episodic myocardial ischemia.
Myopathies, Structural, Congenital
Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients.
Loss of Dynamin 2 GTPase function results in microcytic anaemia.
Mice lacking microRNA 133a develop dynamin 2-dependent centronuclear myopathy.
Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction.
Myopia
Identification of novel X-linked gain-of-function RPGR-ORF15 mutation in Italian family with retinitis pigmentosa and pathologic myopia.
Myotoxicity
Geranylgeraniol Prevents Statin-Dependent Myotoxicity in C2C12 Muscle Cells through RAP1 GTPase Prenylation and Cytoprotective Autophagy.
Inhibition of Rab1 GTPase and endoplasmic reticulum-to-Golgi trafficking underlies statin's toxicity in rat skeletal myofibers.
Myxoma
Juxta-articular myxoma and intramuscular myxoma are two distinct entities. Activating Gs alpha mutation at Arg 201 codon does not occur in juxta-articular myxoma.
Odontogenic myxomas are not associated with activating mutations of the Gs alpha gene.
Odontogenic myxomas are not associated with GNAS1 mutations.
Sporadic cardiac myxomas and tumors from patients with Carney complex are not associated with activating mutations of the Gs alpha gene.
Nasopharyngeal Carcinoma
Promoter hypermethylation of Ras-related GTPase gene RRAD inactivates a tumor suppressor function in nasopharyngeal carcinoma.
Rab1A promotes cancer metastasis and radioresistance through activating GSK-3?/Wnt/?-catenin signaling in nasopharyngeal carcinoma.
Transducin ?-like 1 X-linked receptor 1 suppresses cisplatin sensitivity in nasopharyngeal carcinoma via activation of NF-?B pathway.
Neoplasm Metastasis
Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A.
Aberrant expression of Rab1A and its prognostic significance in human colorectal cancer.
ALEX1, a novel tumor suppressor gene, inhibits gastric cancer metastasis via the PAR-1/Rho GTPase signaling pathway.
An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism.
An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis.
ARF1 controls Rac1 signaling to regulate migration of MDA-MB-231 invasive breast cancer cells.
Circ_0000218 plays a carcinogenic role in colorectal cancer progression by regulating miR-139-3p/RAB1A axis.
Correlation of the Rac1/RhoA Pathway With Ezrin Expression in Osteosarcoma.
Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma.
Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.
DLC1 suppresses distant dissemination of human hepatocellular carcinoma cells in nude mice through reduction of RhoA GTPase activity, actin cytoskeletal disruption and down-regulation of genes involved in metastasis.
DNA methylation-mediated silencing of matricellular protein dermatopontin promotes hepatocellular carcinoma metastasis by ?3?1 integrin-Rho GTPase signaling.
Endothelial Rab7 GTPase Mediates Tumor Growth and Metastasis in Lysosomal Acid Lipase Deficient Mice.
EphB3 Stimulates Cell Migration and Metastasis in a Kinase-dependent Manner through Vav2-Rho GTPase Axis in Papillary Thyroid Cancer.
Expression of Rab1A in bladder cancer and its clinical implications.
Expression of Rac-1 related to tumor depth, lymph node metastasis and patient prognosis in esophageal squamous cell carcinoma.
G'rab'bing the microenvironment for invasion.
Gallic acid inhibits gastric cancer cells metastasis and invasive growth via increased expression of RhoB, downregulation of AKT/small GTPase signals and inhibition of NF-?B activity.
GPR116, an Adhesion G-Protein-Coupled Receptor, Promotes Breast Cancer Metastasis via the G?q-p63RhoGEF-Rho GTPase Pathway.
GPR78 promotes lung cancer cell migration and metastasis by activation of G?q-Rho GTPase pathway.
Heterotrimeric G protein signaling in cancer cells with regard to metastasis formation.
Heterotrimeric G-protein alpha-12 (G?12) subunit promotes oral cancer metastasis.
High expression of Ran GTPase is associated with local invasion and metastasis of human clear cell renal cell carcinoma.
High-resolution structure of the Tiam1 PHn-CC-Ex domain.
In-depth NMR characterization of Rab4a structure, nucleotide exchange and hydrolysis kinetics reveals an atypical GTPase profile.
Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells.
Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization.
Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
IQGAP1?siRNA inhibits proliferation and metastasis of U251 and U373 glioma cell lines.
IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells.
IRGM promotes melanoma cell survival through autophagy and is a promising prognostic biomarker for clinical application.
Long Noncoding RNA MNX1 antisense RNA 1 Exerts Oncogenic Functions in Bladder Cancer by Regulating miR-218-5p/RAB1A Axis.
LyGDI functions in cancer metastasis by anchoring Rho proteins to the cell membrane.
Mass spectroscopic phosphoprotein mapping of Ral binding protein 1 (RalBP1/Rip1/RLIP76).
Metastasis Suppressors NME1 and NME2 Promote Dynamin 2 Oligomerization and Regulate Tumor Cell Endocytosis, Motility, and Metastasis.
Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways.
P-REX1-Independent, Calcium-Dependent RAC1 Hyperactivation in Prostate Cancer.
p38{gamma} promotes breast cancer cell motility and metastasis through regulation of RhoC GTPase, cytoskeletal architecture, and a novel leading edge behavior.
Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells.
Pooled analysis of prognostic value and clinical significance of Rab1A expression in human solid tumors.
Prognostic relevance of increased Rac GTPase expression in prostate carcinomas.
Prognostic significance of TBL1XR1 in predicting liver metastasis for early stage colorectal cancer.
Prognostic significance of Tiam1 expression in papillary thyroid carcinoma.
Rab1A promotes cancer metastasis and radioresistance through activating GSK-3?/Wnt/?-catenin signaling in nasopharyngeal carcinoma.
Rab1A promotes cell proliferation and migration by upregulating Gli1 in colorectal cancer.
Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.
Rac activation and inactivation control plasticity of tumor cell movement.
Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo.
Ran GTPase in Nuclear Envelope Formation and Cancer Metastasis.
Ran GTPase protein promotes metastasis and invasion in pancreatic cancer by deregulating the expression of AR and CXCR4.
Ran GTPase: A Key Player in Tumor Progression and Metastasis.
Ras Homolog Family Member F, Filopodia Associated Promotes Hepatocellular Carcinoma Metastasis by Altering the Metabolic Status of Cancer Cells Through RAB3D.
Rationalizing Rac1 and RhoA GTPase signaling: A mathematical approach.
Reduced RhoA expression enhances breast cancer metastasis with a concomitant increase in CCR5 and CXCR4 chemokines signaling.
RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck.
RhoC GTPase is required for PC-3 prostate cancer cell invasion but not motility.
RhoC Impacts the Metastatic Potential and Abundance of Breast Cancer Stem Cells.
Role of IQGAP3 in metastasis and epithelial-mesenchymal transition in human hepatocellular carcinoma.
SEC-induced activation of ANXA7 GTPase suppresses prostate cancer metastasis.
SIPA1 enhances SMAD2/3 expression to maintain stem cell features in breast cancer cells.
Specific repression of mutant K-RAS by 10-23 DNAzyme: sensitizing cancer cell to anti-cancer therapies.
Swiprosin-1 stimulates cancer invasion and metastasis by increasing the Rho family of GTPase signaling.
TBL1XR1 is involved in c-Met-mediated tumorigenesis of human nonsmall cell lung cancer.
TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia.
The effect of RhoC siRNA on the invasiveness and proliferation of human cervical cancer cell line SiHa cells.
The inhibition of the effect and mechanism of vascular intimal hyperplasia in Tiam1 knockout mice.
The Tiam1 Guanine Nucleotide Exchange Factor is Auto-inhibited by its Pleckstrin Homology Coiled-Coil Extension Domain.
The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.
Timing of Novel Drug 1A-116 to Circadian Rhythms Improves Therapeutic Effects against Glioblastoma.
Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma.
Type I collagen receptor (alpha2beta1) signaling promotes prostate cancer invasion through RhoC GTPase.
Up-regulation of T-lymphoma and metastasis gene 1 in gastric cancer and its involvement in cell invasion and migration.
Upregulation of LINC00659 expression predicts a poor prognosis and promotes migration and invasion of gastric cancer cells.
[Effect of GTPase activating protein Git2 on metastasis in breast cancer].
[Effects of RAB1A on the proliferation, invasion, and metastasis of tongue squamous cell carcinoma cells].
Neoplasms
1'-Acetoxychavicol Acetate Suppresses Angiogenesis-Mediated Human Prostate Tumor Growth by Targeting VEGF-Mediated Src-FAK-Rho GTPase Signaling Pathway.
11q13 allelic loss in pituitary tumors in patients with multiple endocrine neoplasia syndrome type 1.
1H, 15N backbone assignment and comparative analysis of the wild type and G12C, G12D, G12V mutants of K-Ras bound to GDP at physiological pH.
?3?1 integrins regulate CD151 complex assembly and membrane dynamics in carcinoma cells within 3D environments.
A case report of tongue metastasis from lung squamous cell carcinoma and literature review.
A diketopiperazine fragment of human serum albumin modulates T-lymphocyte cytokine production through rap1.
A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis.
A neuronal network of mitochondrial dynamics regulates metastasis.
A novel mechanism by which tissue transglutaminase activates signaling events that promote cell survival.
A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype.
A pituitary specific point mutation of codon 201 of the Gs alpha gene in a pituitary adenoma of a patient with multiple endocrine neoplasia (MEN) type 1.
A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination.
A thirty-year quest for a role of R-Ras in cancer: from an oncogene to a multitasking GTPase.
A transcriptional cross-talk between RhoA and c-Myc inhibits the RhoA/Rock-dependent cytoskeleton.
Aberrant expression of Rab1A and its prognostic significance in human colorectal cancer.
Aberrant methylation of the Ras-related associated with diabetes gene in human primary esophageal cancer.
Ablation of Goalpha overrides G1 restriction point control through Ras/ERK/cyclin D1-CDK activities.
Abnormal methylation of GRAF promoter Chinese patients with acute myeloid leukemia.
Acromegaly in a family without a mutation in the menin gene.
Activated Galpha subunits can inhibit multiple signal transduction pathways during Dictyostelium development.
Activating genomic alterations in the Gs alpha gene (GNAS) in 274?694 tumors.
Activating Gs alpha mutation at the Arg201 codon in liposclerosing myxofibrous tumor.
Activating mutation in the stimulatory guanine nucleotide-binding protein in an infant with Cushing's syndrome and nodular adrenal hyperplasia.
Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors.
Activating mutations of the Gs alpha gene are associated with low levels of Gs alpha protein in growth hormone-secreting tumors.
Activating mutations of the Gs alpha-gene in nonfunctioning pituitary tumors.
Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation.
Active and Inactive Cdc42 Differ in Their Insert Region Conformational Dynamics.
Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning.
ADP-ribosylation factor 1 expression regulates epithelial-mesenchymal transition and predicts poor clinical outcome in triple-negative breast cancer.
ALEX1, a novel tumor suppressor gene, inhibits gastric cancer metastasis via the PAR-1/Rho GTPase signaling pathway.
Allosteric modulation of Ras and the PI3K/AKT/mTOR pathway: emerging therapeutic opportunities.
Allosteric modulation of Ras positions Q61 for a direct role in catalysis.
Allosteric modulation of Ras-GTP is linked to signal transduction through RAF kinase.
Alterations in guanine nucleotide regulatory protein expression and activity in human hepatocellular carcinoma.
Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis.
Amplified expression of p21 ras protein in hormone-dependent mammary carcinomas of humans and rodents.
An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis.
An immune escape screen reveals Cdc42 as regulator of cancer susceptibility to lymphocyte-mediated tumor suppression.
An in vitro model of thyroid neoplasia: permanently transfected FRTL-5 cells with thyroglobulin promoter-cholera toxin A1 subunit minigene.
Analysis of binding site hot spots on the surface of Ras GTPase.
Analysis of mutations in genes of the follicle-stimulating hormone receptor signaling pathway in ovarian granulosa cell tumors.
Analysis of mutations in the Gs protein alpha subunit gene in human leukaemia.
Analysis of the Gs alpha gene in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues.
Anticancer Activity of BIM-46174, a New Inhibitor of the Heterotrimeric G{alpha}/G{beta}{gamma} Protein Complex.
Antimetastatic effects of gambogic acid are mediated via the actin cytoskeleton and NF-?B pathways in SK-HEP1 cells.
Application of the antitussive agents oxelaidin and butamirate as anti-glioma agents.
ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer.
ARHGAP6 regulates the proliferation, migration and invasion of lung cancer cells.
Association of elongation factor 2 with ribosomes during growth of a murine ascitic tumor.
Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22.
Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations.
Autophagy in the physiological endometrium and cancer.
Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice.
Bioinformatics analysis of potential therapeutic targets among ARHGAP genes in breast cancer.
Biology and management of inflammatory breast cancer.
C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies.
Cancer Cell Invasion in Three-dimensional Collagen Is Regulated Differentially by G?13 Protein and Discoidin Domain Receptor 1-Par3 Protein Signaling.
Cancer-Associated Point Mutations in the DLC1 Tumor Suppressor and Other Rho-GAPs Occur Frequently and Are Associated with Decreased Function.
CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma.
Catalytically Competent Non-transforming H-RASG12P Mutant Provides Insight into Molecular Switch Function and GAP-independent GTPase Activity of RAS.
Caveolae as a target to quench autoinduction of the metastatic phenotype in lung cancer.
cDNA microarray analysis of vestibular schwannomas.
cDNA structure, alternative splicing and exon-intron organization of the predisposing tuberous sclerosis (Tsc2) gene of the Eker rat model.
Characterization of genomic alterations and the significance of PI3K/mTOR pathway mutations and tumor mutational burden in non?small cell lung cancer.
Chemical reverse transformation of CHO-K1 cells induces changes in expression of a candidate tumour suppressor and of a gene not previously characterised as transformation related.
Ciclosporin inhibits phorbol-ester-induced hyperplastic transformation and tumor promotion in mouse skin probably by suppression of Ca2+/calmodulin-dependent processes such as phosphorylation of elongation factor 2.
Circadian locomotor output cycles kaput affects the proliferation and migration of breast cancer cells by regulating the expression of E-cadherin via IQ motif containing GTPase activating protein 1.
CircRNA circUGGT2 Contributes to Hepatocellular Carcinoma Development via Regulation of the miR-526b-5p/RAB1A Axis.
Clinical and Genetic Risk Factors for Perianal Crohn's Disease in a Population-Based Cohort.
Clonal origin of toxic thyroid nodules with constitutively activating thyrotropin receptor mutations.
Codon usage regulates human KRAS expression at both transcriptional and translational levels.
Collective cancer cell invasion requires RNA accumulation at the invasive front.
Combination therapies for MPNSTs targeting RABL6A-RB1 signaling.
Comparative transcriptional analysis reveals distinct expression patterns of channel catfish genes after the first infection and re-infection with Aeromonas hydrophila.
Comparative Transcriptomics Analysis of Testicular miRNA from Cryptorchid and Normal Horses.
Comparison of tissue-selective proinflammatory gene induction in mice infected with wild-type, DNA adenine methylase-deficient, and flagellin-deficient Salmonella enterica.
Computational inference of cancer-specific vulnerabilities in clinical samples.
Concepts in Ras-directed therapy.
Concomitant presence of JAK2V617F mutation and BCR?ABL translocation in two patients: A new entity or a variant of myeloproliferative neoplasms (Case report).
Coordinated activation of the Rac-GAP ?2-chimaerin by an atypical proline-rich domain and diacylglycerol.
Correlation of the Rac1/RhoA Pathway With Ezrin Expression in Osteosarcoma.
Covalent Guanosine Mimetic Inhibitors of G12C KRAS.
Critical role of oncogenic KRAS in pancreatic cancer (Review).
CRMP5-associated GTPase (CRAG) Is a Candidate Driver Gene for Colorectal Cancer Carcinogenesis.
Cushing's syndrome due to bilateral adrenocortical adenomas with different pathological features.
Cytoplasmic p27Kip1 promotes tumorigenesis via suppression of RhoB activity.
Data Independent Acquisition Proteomic Analysis Can Discriminate between Actinic Keratosis, Bowen's Disease, and Cutaneous Squamous Cell Carcinoma.
Death-associated protein kinase 1 suppresses hepatocellular carcinoma cell migration and invasion by upregulation of DEAD-box helicase 20.
Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.
Decreased 8N3-[gamma-32P]GTP photolabeling of Gs alpha in tumorigenic lung epithelial cell lines: association with decreased hormone responsiveness and loss of contact-inhibited growth.
Decreased GTPase activity of K-ras mutants deriving from human functional adrenocortical tumours.
Decreased incorporation of the photoaffinity probe 8N3-[gamma-32P]-GTP into a 45kD protein in lung tumors.
Defining clinically relevant molecular subsets of lung cancer.
Detection of gsp oncogene in growth hormone-secreting pituitary adenomas and the study of clinical characteristics of acromegalic patients with gsp-positive pituitary tumors.
Detection of label-free cancer biomarkers using nickel nanoislands and quartz crystal microbalance.
Development of EHop-016: a small molecule inhibitor of Rac.
Dichotomous roles of claudins as tumor promoters or suppressors: lessons from knockout mice.
Differences in GTPase-activating protein activity between liver tumors and normal liver tissue in mice.
DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1.
Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP.
Discrimination of low- and high-grade appendiceal mucinous neoplasms by targeted sequencing of cancer-related variants.
Dissecting the roles of Ephrin-A3 in malignant peripheral nerve sheath tumor by TALENs.
Distinct functional relevance of dynamic GTPase cysteine methylation in fission yeast.
DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway.
Do PAKs make good drug targets?
Dominant negative Rac1 attenuates paclitaxel-induced apoptosis in human melanoma cells through upregulation of heat shock protein 27: a functional proteomic analysis.
Down-regulation of beta-adrenergic receptors by pindolol in Gs alpha-transfected S49 cyc- murine lymphoma cells.
Downregualtion of dynamin-related protein 1 attenuates glutamate-induced excitotoxicity via regulating mitochondrial function in a calcium dependent manner in HT22 cells.
Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation.
Dynamin II function is required for EGF-mediated Stat3 activation but not Erk1/2 phosphorylation.
Dysregulation of GTPase IMAP family members in hepatocellular cancer.
Effect of tumor necrosis factor on GTP binding and GTPase activity in HL-60 and L929 cells.
Effect of tumor promoting phorbol ester TPA on epidermal protein synthesis: stimulation of an elongation factor 2 phosphatase activity by TPA in vivo.
EGF ligand fused to truncated Pseudomonas aeruginosa exotoxin A specifically targets and inhibits EGFR?positive cancer cells.
Elevated expression of ECT2 predicts unfavorable prognosis in patients with colorectal cancer.
Elongation factor 1 from ascites tumor cells: interaction with ribosomes and elongation factor 2.
Emergence and scattering of multiple neurofibromatosis (NF1)-related sequences during hominoid evolution suggest a process of pericentromeric interchromosomal transposition.
Emergence of the Dedifferentiated Phenotype in Hepatocyte-Derived Tumors in Mice: Roles of Oncogene-Induced Epigenetic Alterations.
Emerging views of mitophagy in immunity and autoimmune diseases.
Endocrine manifestations of stimulatory G protein alpha-subunit mutations and the role of genomic imprinting.
Endothelial Rab7 GTPase Mediates Tumor Growth and Metastasis in Lysosomal Acid Lipase Deficient Mice.
ENO1 Acts as a Prognostic Biomarker Candidate and Promotes Tumor Growth and Migration Ability Through the Regulation of Rab1A in Colorectal Cancer.
Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer.
Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.
Epithelial cell transforming sequence 2 in human oral cancer.
ERK-dependent suicide gene therapy for selective targeting of RTK/RAS-driven cancers.
Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth.
Essential role of the cancer stem/progenitor cell marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast cancer cells.
Evaluation of active Rac1 levels in cancer cells: A case of misleading conclusions from immunofluorescence analysis.
Evolutionarily conserved role of nucleostemin: controlling proliferation of stem/progenitor cells during early vertebrate development.
Expression analysis and implication of Rab1A in gastrointestinal relevant tumor.
Expression and role of EGFR, cyclin D1 and KRAS in laryngocarcinoma tissues.
Expression of CCT6A mRNA in chicken granulosa cells is regulated by progesterone.
Expression of functional stimulatory guanine nucleotide binding protein in nonfunctioning thyroid adenomas is not correlated to adenylate cyclase activity and growth of these tumors.
Expression of G protein alpha subunits in normal rat colon and in azoxymethane-induced colonic neoplasms.
Expression of mutationally activated G alpha s stimulates growth and differentiation of thyroid FRTL5 cells.
Expression of Rab1A in bladder cancer and its clinical implications.
Expression of Rab1A is upregulated in human lung cancer and associated with tumor size and T stage.
Expression of Rac-1 related to tumor depth, lymph node metastasis and patient prognosis in esophageal squamous cell carcinoma.
Expression pattern of the PRDX2, RAB1A, RAB1B, RAB5A and RAB25 genes in normal and cancer cervical tissues.
Expression, purification, and characterization of soluble K-Ras4B for structural analysis.
Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies.
FGFR1 is essential for N-acetyl-seryl-aspartyl-lysyl-proline regulation of mitochondrial dynamics by upregulating microRNA let-7b-5p.
Fragile Histidine Triad Mediated Tumor Suppression of Lung Cancer by Targeting Multiple Components of the Ras/Rho GTPase Molecular Switch.
Frequent Heterogeneous Missense Mutations of GGAP2 in Prostate Cancer: Implications for Tumor Biology, Clonality and Mutation Analysis.
Functional expression of NF1 tumor suppressor protein: association with keratin intermediate filaments during the early development of human epidermis.
G protein ? subunit 7 induces autophagy and inhibits cell division.
G protein abnormalities in pituitary adenomas.
G protein mutations in tumours of the pituitary, parathyroid and endocrine pancreas.
G protein oncogenes in pituitary tumors.
G'rab'bing the microenvironment for invasion.
G-protein alpha(olf) subunit promotes cellular invasion, survival, and neuroendocrine differentiation in digestive and urogenital epithelial cells.
G?13-mediated LATS1 down-regulation contributes to epithelial-mesenchymal transition in ovarian cancer.
G?s protein expression is an independent predictor of recurrence in prostate cancer.
Gene trap mutagenesis-based forward genetic approach reveals that the tumor suppressor OVCA1 is a component of the biosynthetic pathway of diphthamide on elongation factor 2.
Genetic aspects of pituitary tumors.
Genomic profile - a possible diagnostic and prognostic marker in upper tract urothelial carcinoma.
Genomic sequence analysis of a key residue (Arg183) in human G alpha q in invasive non-functional pituitary adenomas.
Glycoprotein hormone alpha-subunit production in somatotroph adenomas with and without Gs alpha mutations.
GNAS1 (G?s) Gene T393C Polymorphism and Renal Cell Carcinoma Risk in a North Indian Population: A Case-Control Study.
GNG2 inhibits invasion of human malignant melanoma cells with decreased FAK activity.
GPER Activation Inhibits Cancer Cell Mechanotransduction and Basement Membrane Invasion via RhoA.
Growth factors regulate cell survival by controlling nutrient transporter expression.
Growth hormone-prolactin-thyrotropin-secreting pituitary adenoma in atypical McCune-Albright syndrome with functionally normal Gs alpha protein.
Gs alpha mutation may be uncommon in patients with multiple endocrine neoplasia type 1.
Gs alpha overexpression and loss of Gs alpha imprinting in human somatotroph adenomas: association with tumor size and response to pharmacologic treatment.
Gs alpha--identification of a gene highly expressed by insulinoma and other endocrine tumors.
Gs(alpha) mutations and imprinting defects in human disease.
GTPase regulator associated with the focal adhesion kinase (GRAF) transcript was down-regulated in patients with myeloid malignancies.
Guanine nucleotide-binding protein subunit beta-4 promotes gastric cancer progression via activating Erk1/2.
Guanosine triphosphatase stimulation of oncogenic Ras mutants.
Guanylate-binding protein-2 inhibits colorectal cancer cell growth and increases the sensitivity to paclitaxel of paclitaxel-resistant colorectal cancer cells by interfering Wnt signaling.
Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes.
HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases.
Heterotrimeric G protein signaling in cancer cells with regard to metastasis formation.
Heterotrimeric G-protein alpha-12 (G?12) subunit promotes oral cancer metastasis.
High expression of IQGAP3 indicates poor prognosis in colorectal cancer patients.
High salinity induced expression profiling of differentially expressed genes in shrimp (Penaeus monodon).
Higher levels of dynamin-related protein 1 are associated with reduced radiation sensitivity of glioblastoma cells.
How autophagy controls the intestinal epithelial barrier.
HRAS as a potential therapeutic target of salirasib RAS inhibitor in bladder cancer.
Hsc70 contributes to cancer cell survival by preventing Rab1A degradation under stress conditions.
Human breast cancer MDA-MB-231 cells fail to express the neurofibromin protein, lack its type I mRNA isoform and show accumulation of P-MAPK and activated Ras.
Hypoxia-mediated miR-212-3p downregulation enhances progression of intrahepatic cholangiocarcinoma through upregulation of Rab1a.
Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome.
Identification of an autoinhibitory mechanism that restricts C1 domain-mediated activation of the Rac-GAP alpha2-chimaerin.
Identification of G protein alpha subunit mutations in human growth hormone (GH)- and GH/prolactin-secreting pituitary tumors by single-strand conformation polymorphism (SSCP) analysis.
Identification of genes differentially expressed between benign and osteopontin transformed rat mammary epithelial cells.
Identification of heat shock protein 90 and other proteins as tumour antigens by serological screening of an ovarian carcinoma expression library.
Identification of NF1 mutations in both alleles of a dermal neurofibroma.
Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury.
IFNg-induced Irgm1 promotes tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy.
Immunodetection of G proteins in human pituitary adenomas: evidence for a low expression of proteins of the Gi subfamily.
Impact of Cadmium on Intracellular Zinc Levels in HepG2 Cells: Quantitative Evaluations and Molecular Effects.
Impact of combined mTOR and MEK inhibition in uveal melanoma is driven by tumor genotype.
Increased Ras GTPase activity is regulated by miRNAs that can be attenuated by CDF treatment in pancreatic cancer cells.
Induction of human microsomal prostaglandin E synthase 1 by activated oncogene RhoA GTPase in A549 human epithelial cancer cells.
Inhibition of endothelial cell proliferation by targeting Rac1 GTPase with small interference RNA in tumor cells.
Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells.
Inhibition of the RhoA GTPase Activity Increases Sensitivity of Melanoma Cells to UV Radiation Effects.
Inhibition of tumor cell motility by the interferon-inducible GTPase MxA.
Inhibitors of protein farnesyltransferase as novel anticancer agents.
Integrated Analysis of the Clinical and Molecular Characteristics of IDH Wild-Type Gliomas in the Chinese Glioma Genome Atlas.
Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation.
Integration of quantitative phosphoproteomics and transcriptomics revealed phosphorylation-mediated molecular events as useful tools for a potential patient stratification and personalized treatment of human nonfunctional pituitary adenomas.
Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers.
Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42.
Investigating the role of ADP-ribosylation factor 6 in tumor cell invasion and extracellular signal-regulated kinase activation.
Investigation of GTP-dependent dimerization of G12X K-Ras variants using ultraviolet photodissociation mass spectrometry.
IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway.
IQGAP1 suppresses T?RII-mediated myofibroblastic activation and metastatic growth in liver.
IQGAP1?siRNA inhibits proliferation and metastasis of U251 and U373 glioma cell lines.
IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL.
IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells.
IQGAP2 is a novel interferon-alpha antiviral effector gene acting non-conventionally through the NF-?B pathway.
IQGAP3 Overexpression Correlates With Poor Prognosis and Radiation Therapy Resistance in Breast Cancer.
IQGAP3 promotes cancer proliferation and metastasis in high-grade serous ovarian cancer.
Irgm1 knockout indirectly inhibits regeneration after skeletal muscle injury in mice.
Is current therapy of malignant gliomas beneficial for patients? Proteomics evidence of shifts in glioma cells expression patterns under clinically relevant treatment conditions.
K-Ras G-domain binding with signaling lipid Phosphatidyl inositol (4,5) phosphate (PIP2): Membrane association, protein orientation and function.
K-Ras, Intestinal Homeostasis and Colon Cancer.
Kalopanaxsaponin a inhibits the invasion of human oral squamous cell carcinoma by reducing metalloproteinase-9 mRNA stability and protein trafficking.
Kisspeptin-10, a KISS1-derived decapeptide, inhibits tumor angiogenesis by suppressing Sp1-mediated VEGF expression and FAK/Rho GTPase activation.
Knockdown of RAP2A gene expression suppresses cisplatin resistance in gastric cancer cells.
KRas4B-PDE6? complex stabilization by small molecules obtained by virtual screening affects Ras signaling in pancreatic cancer.
KRASG12C inhibition produces a driver-limited state revealing collateral dependencies.
Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease.
Leukemic potential of doubly mutant Nf1 and Wv hematopoietic cells.
Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5'-triphosphate hydrolysis of p21ras.
Long Noncoding RNA MNX1 antisense RNA 1 Exerts Oncogenic Functions in Bladder Cancer by Regulating miR-218-5p/RAB1A Axis.
Long-acting peptidomimergic control of gigantism caused by pituitary acidophilic stem cell adenoma.
Loss of MIEF1/MiD51 confers susceptibility to BAX-mediated cell death and PINK1-PRKN-dependent mitophagy.
Low prevalence of Gs alpha mutations in śomatotroph adenomas of children and adolescents.
Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines.
Lymphoid blast transformation in an MPN with BCR-JAK2 treated with ruxolitinib: putative mechanisms of resistance.
Macrophage contact induces RhoA GTPase signaling to trigger tumor cell intravasation.
Mammosomatotroph adenoma causing gigantism in an 8-year old boy: a possible pathogenetic mechanism.
Maspin controls mammary tumor cell migration through inhibiting Rac1 and Cdc42, but not the RhoA GTPase.
Mass spectroscopic phosphoprotein mapping of Ral binding protein 1 (RalBP1/Rip1/RLIP76).
Mechanism of GTP hydrolysis by G-protein alpha subunits.
Mechanistic Insights into the Differential Catalysis by RheB and Its Mutants: Y35A and Y35A-D65A.
Met-Gly-Cys motif from G-protein alpha subunit cannot direct palmitoylation when fused to heterologous protein.
Metastasis Suppressors NME1 and NME2 Promote Dynamin 2 Oligomerization and Regulate Tumor Cell Endocytosis, Motility, and Metastasis.
Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers.
MIB1 upregulates IQGAP1 and promotes pancreatic cancer progression by inducing ST7 degradation.
MicroRNA-19b Promotes Nasopharyngeal Carcinoma More Sensitive to Cisplatin by Suppressing KRAS.
MicroRNA-Based Therapeutic Strategies for Targeting Mutant and Wild Type RAS in Cancer.
MicroRNA?4500 suppresses tumor progression in non?small cell lung cancer by regulating STAT3.
Minireview: GNAS: normal and abnormal functions.
MiR-1202 functions as a tumor suppressor in glioma cells by targeting Rab1A.
miR-15b-5p induces endoplasmic reticulum stress and apoptosis in human hepatocellular carcinoma, both in vitro and in vivo, by suppressing Rab1A.
MiR-655-3p inhibited proliferation and migration of ovarian cancer cells by targeting RAB1A.
miR?139?3p suppresses the invasion and migration properties of breast cancer cells by targeting RAB1A.
Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer.
Mitophagy in degenerative joint diseases.
Modelling GTPase dynamics to understand RhoA-driven cancer cell invasion.
Modulation of RhoA GTPase Activity Sensitizes Human Cervix Carcinoma Cells to ?-Radiation by Attenuating DNA Repair Pathways.
Molecular aspects of the pathogenesis of nodular goiters, thyroid nodules and adenomas.
Molecular determinants of the inflammatory breast cancer phenotype.
Molecular epidemiologic features of inflammatory breast cancer: a comparison between Egyptian and US patients.
Molecular genetic studies of sporadic pituitary tumors.
Molecular mechanisms of platelet activation and aggregation induced by breast cancer cells.
Molecular mutation characteristics of mismatch and homologous recombination repair genes in gastrointestinal cancer.
Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting rho GTPases and extracellular signal-regulated kinase signaling pathways.
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.
mTORC1 gRABs the Golgi.
Multiplexed Real-Time NMR GTPase Assay for Simultaneous Monitoring of Multiple Guanine Nucleotide Exchange Factor Activities from Human Cancer Cells and Organoids.
Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes.
Neurofibromatosis 1 gene (NF1) mutation is a rare genetic event in myelodysplastic syndrome regardless of the disease progression.
Neurofibromatosis type 1: Fundamental insights into cell signalling and cancer.
Neurofibromin binds to caveolin-1 and regulates ras, FAK, and Akt.
Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy.
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Next-generation sequencing identified somatic alterations that may underlie the etiology of Chinese papillary thyroid carcinoma.
NF1 inactivation cooperates with N-ras in in vivo lymphogenesis activating Erk by a mechanism independent of its Ras-GTPase accelerating activity.
NMR-based functional profiling of RASopathies and oncogenic RAS mutations.
No evidence for oncogenic mutations in guanine nucleotide-binding proteins of human adrenocortical neoplasms.
Nonsense mutations in the C-terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours.
Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display.
Nuclear expression of dynamin-related protein 1 in lung adenocarcinomas.
Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF.
Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance.
Oncogenic G Protein GNAQ Induces Uveal Melanoma and Intravasation in Mice.
Oncogenic K-Ras Regulates Bioactive Sphingolipids in a Sphingosine Kinase 1-dependent Manner.
Oncogenic mutations of alpha-Gi2 protein are not determinant for human adrenocortical tumourigenesis.
Oncogenic role of heterotrimeric G proteins.
Over-Expression of TBL1XR1 Indicates Poor Prognosis of Serous Epithelial Ovarian Cancer.
Overexpression and clinical significance of IBP in epithelial ovarian carcinoma.
Overexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomas.
Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer.
Overexpression of Gs alpha subunit in thyroid tumors bearing a mutated Gs alpha gene.
Overexpression of IQGAP1 promotes the angiogenesis of esophageal squamous cell carcinoma through the AKT and ERK?mediated VEGF?VEGFR2 signaling pathway.
Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster.
Overexpression of MTH1 and OGG1 proteins in ulcerative colitis-associated carcinogenesis.
Overexpression of optic atrophy 1 protein increases cisplatin resistance via inactivation of caspase-dependent apoptosis in lung adenocarcinoma cells.
Overexpression of Ran GTPase Components Regulating Nuclear Export, but not Mitotic Spindle Assembly, Marks Chromosome Instability and Poor Prognosis in Breast Cancer.
Overexpression of the regulator of G-protein signaling 5 reduces the survival rate and enhances the radiation response of human lung cancer cells.
P-REX1-Independent, Calcium-Dependent RAC1 Hyperactivation in Prostate Cancer.
p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities.
p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas.
P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance.
Pancreatic cancer: modulation of KRAS, MicroRNAs, and intercellular communication in the setting of tumor heterogeneity.
Parathyroid-targeted overexpression of Regulator of G-Protein Signaling 5 (R GS5) causes hyperparathyroidism in transgenic mice.
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Ph(-) myeloproliferative neoplasm red blood cells display deregulation of IQGAP1-Rho GTPase signaling depending on CALR/JAK2 status.
Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings.
Phosphorylation of FADD by the kinase CK1? promotes KRASG12D-induced lung cancer.
Phosphorylation of merlin regulates its stability and tumor suppressive activity.
PI3K and RAC signalling in leukocyte and cancer cell migration.
Pituitary adenomas: screening for G alpha q mutations.
PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin.
Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells.
Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells.
Point mutations of ras and Gs alpha subunit genes in thyroid tumors.
Polypeptide expression in prostate hyperplasia and prostate adenocarcinoma.
Pooled analysis of prognostic value and clinical significance of Rab1A expression in human solid tumors.
Potent transforming activity of the G13 alpha subunit defines a novel family of oncogenes.
Presence of a Gs alpha mutation in an adrenal tumor expressing LH/hCG receptors and clinically associated with Cushing's syndrome.
Prevalences of Gs alpha, ras, p53 mutations and ret/PTC rearrangement in differentiated thyroid tumours in a Korean population.
PREX2 promotes the proliferation, invasion and migration of pancreatic cancer cells by modulating the PI3K signaling pathway.
Prognosis Significance and Positive Correlation of Rab1A and p-S6K/Gli1 Expression in Gastric Cancer.
Prognostic relevance of increased Rac GTPase expression in prostate carcinomas.
Prognostic value of KRAS/TP53/PIK3CA in non-small cell lung cancer.
Promoter hypermethylation of Ras-related GTPase gene RRAD inactivates a tumor suppressor function in nasopharyngeal carcinoma.
Pronostic and therapeutic consequences of Gs alpha mutations in somatotroph adenomas.
Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors.
Rab1A is an mTORC1 activator and a colorectal oncogene.
Rab1A knockdown represses proliferation and promotes apoptosis in gastric cancer cells by inhibition of mTOR/p70S6K pathway.
Rab1A promotes cancer metastasis and radioresistance through activating GSK-3?/Wnt/?-catenin signaling in nasopharyngeal carcinoma.
Rab1A promotes cell proliferation and migration by upregulating Gli1 in colorectal cancer.
Rab1A promotes proliferation and migration abilities via regulation of the HER2/AKT-independent mTOR/S6K1 pathway in colorectal cancer.
Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.
Rab25 GTPase: Functional roles in cancer.
Rab35 GTPase and cancer: Linking membrane trafficking to tumorigenesis.
Rab35 GTPase: A Central Regulator of Phosphoinositides and F-actin in Endocytic Recycling and Beyond.
RAB38 Facilitates Energy Metabolism and Counteracts Cell Death in Glioblastoma Cells.
Rab7 GTPase controls lipid metabolic signaling in myeloid-derived suppressor cells.
RABL6A Regulates Schwann Cell Senescence in an RB1-Dependent Manner.
Rac signaling in breast cancer: a tale of GEFs and GAPs.
Rac signaling in tumorigenesis and as target for anticancer drug development.
RAC1 plays an essential role in estrogen receptor alpha function in breast cancer cells.
Rac1-mediated sustained ?4 integrin level develops reattachment ability of breast cancer cells after anchorage loss.
Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo.
Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression.
Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion.
RalB signaling: a bridge between inflammation and cancer.
RAN GTPase as a target for cancer therapy: Ran binding proteins.
Ran GTPase in Nuclear Envelope Formation and Cancer Metastasis.
Ran GTPase is an independent prognostic marker in malignant melanoma which promotes tumour cell migration and invasion.
Ran GTPase promotes cancer progression via Met recepto-rmediated downstream signaling.
Ran GTPase: A Key Player in Tumor Progression and Metastasis.
Ran-binding protein 3 is associated with human spermatogenesis and male infertility.
Rap1 activity is elevated in malignant astrocytomas independent of tuberous sclerosis complex-2 gene expression.
Rap1 GTPase Inhibits Tumor Necrosis Factor-?-Induced Choroidal Endothelial Migration via NADPH Oxidase- and NF-?B-Dependent Activation of Rac1.
RAP1 GTPase overexpression is associated with cervical intraepithelial neoplasia.
Rap1 GTPase: functions, regulation, and malignancy.
Rapid Somatic Mutation Testing in Colorectal Cancer by Use of a Fully Automated System and Single-Use Cartridge: A Comparison with Next-Generation Sequencing.
Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction-primer-introduced restriction analysis.
RAS and RHO family GTPase mutations in cancer: twin sons of different mothers?
Ras Homolog Family Member F, Filopodia Associated Promotes Hepatocellular Carcinoma Metastasis by Altering the Metabolic Status of Cancer Cells Through RAB3D.
Ras mutational status is a biomarker for resistance to EGFR inhibitors in colorectal carcinoma.
Ras stabilization through aberrant activation of Wnt/?-catenin signaling promotes intestinal tumorigenesis.
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
Ras-induced epigenetic inactivation of Ras-related associated with diabetes gene (RRAD) promotes glucose uptake in a human ovarian cancer model.
RAS-MEK independent gene expression reveals BMP2-related malignant phenotypes in the Nf1-deficient MPNST.
RAS-related GTPases DIRAS1 and DIRAS2 induce autophagic cancer cell death and are required for autophagy in murine ovarian cancer cells.
RASAL2 down-regulation in ovarian cancer promotes epithelial-mesenchymal transition and metastasis.
Rational design of small molecule RHOA inhibitors for gastric cancer.
Recombinant human thrombopoietin combined with interleukin-2 improves the effects of chemosensitivity and thrombocytopenia on a basic gemcitabine and carboplatin combination therapy for non-small cell lung cancer in a nude mouse model.
Reduced constitutive 8-oxoguanine-DNA glycosylase expression and impaired induction following oxidative DNA damage in the tuberin deficient Eker rat.
Reduced expression of GNA11 and silencing of MCT1 in human breast cancers.
Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and caveolin-1.
Renal gene expression in embryonic and newborn diabetic mice.
Reverse pharmacophore mapping and molecular docking studies for discovery of GTPase HRas as promising drug target for bis-pyrimidine derivatives.
Rho GTPases: Anti- or pro-neoplastic targets?
RhoA modulates functional and physical interaction between ROCK1 and Erk1/2 in selenite-induced apoptosis of leukaemia cells.
RhoA protein expression correlates positively with degree of malignancy in astrocytomas.
RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells.
RhoA/ROCK pathway inhibition by fasudil suppresses the vasculogenic mimicry of U2OS osteosarcoma cells in vitro.
RhoC GTPase activation assay.
RhoC GTPase is required for PC-3 prostate cancer cell invasion but not motility.
RhoC GTPase overexpression modulates induction of angiogenic factors in breast cells.
RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype.
RhoC induces differential expression of genes involved in invasion and metastasis in MCF10A breast cells.
RhoGDI2 expression is associated with tumor growth and malignant progression of gastric cancer.
RIN1 promotes renal cell carcinoma malignancy by activating EGFR signaling through Rab25.
RNA processing and clinical variability in neurofibromatosis type I (NF1).
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
ROCK1 and ROCK2 are Required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion.
ROCK2 mediates osteosarcoma progression and TRAIL resistance by modulating O-GlcNAc transferase degradation.
Role of GTPases and GTPase regulatory proteins in oncogenesis.
Role of IQGAP3 in metastasis and epithelial-mesenchymal transition in human hepatocellular carcinoma.
Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells.
RRAD inhibits aerobic glycolysis, invasion, and migration and is associated with poor prognosis in hepatocellular carcinoma.
Sarcoid-Like Granulomatous Disease: Pathologic Case Series in World Trade Center Dust Exposed Rescue and Recovery Workers.
Screening of candidate oncogenes in human thyrotroph tumors: absence of activating mutations of the G alpha q, G alpha 11, G alpha s, or thyrotropin-releasing hormone receptor genes.
Screening of mutations in the additional sex combs like 1, transcriptional regulator, tumor protein p53, and KRAS proto-oncogene, GTPase/NRAS proto-oncogene, GTPase genes of patients with myelodysplastic syndrome.
Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis.
Selective Oral MEK1/2 Inhibitor Pimasertib in Metastatic Melanoma: Antitumor Activity in a Phase I, Dose-Escalation Trial.
Semaphorin 4D expression is associated with a poor clinical outcome in cervical cancer patients.
Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors).
Signaling pathways regulating TC21-induced tumorigenesis.
Significance and prognostic role of human epidermal growth factor receptor 2 and RAB1A expression in gastric cancer.
Significance of Thr182 in the nucleotide-exchange and GTP-hydrolysis reactions of the alpha subunit of GTP-binding protein Gi2.
Significantly increased cortisol secretion in normal adrenocortical cells transfected with K-ras mutants derived from human functional adrenocortical tumors.
Silencing of ARL14 Gene Induces Lung Adenocarcinoma Cells to a Dormant State.
SIPA1 enhances SMAD2/3 expression to maintain stem cell features in breast cancer cells.
Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.
Small guanosine triphosphatase Rho/Rho-associated kinase as a novel regulator of intracellular redistribution of lysosomes in invasive tumor cells.
Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth.
Specific repression of mutant K-RAS by 10-23 DNAzyme: sensitizing cancer cell to anti-cancer therapies.
Sporadic cardiac myxomas and tumors from patients with Carney complex are not associated with activating mutations of the Gs alpha gene.
StarD13: a potential star target for tumor therapeutics.
Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.
Structural studies of the thyrotropin receptor and Gs alpha in human thyroid cancers: low prevalence of mutations predicts infrequent involvement in malignant transformation.
Structure of the BH domain from graf and its implications for Rho GTPase recognition.
Study of the multiple endocrine neoplasia type 1, growth hormone-releasing hormone receptor, Gs alpha, and Gi2 alpha genes in isolated familial acromegaly.
Supporting a Role for the GTPase Rab7 in Prostate Cancer Progression.
Suppression of Myc oncogenic activity by nucleostemin haploinsufficiency.
Suppression of the proliferation and migration of oncogenic ras-dependent cell lines, cultured in a three-dimensional collagen matrix, by flavonoid-structured molecules.
Suppression of Tobacco Carcinogen-Induced Lung Tumorigenesis by Aerosol-Delivered Glycerol Propoxylate Triacrylate-Spermine Copolymer/Short Hairpin Rab25 RNA Complexes in Female A/J Mice.
Swiprosin-1 stimulates cancer invasion and metastasis by increasing the Rho family of GTPase signaling.
Targeting mutated GTPase KRAS in tumor therapies.
Targeting the serrated pathway of colorectal cancer with mutation in BRAF.
TBL1XR1 as a potential therapeutic target that promotes epithelial-mesenchymal transition in lung squamous cell carcinoma.
TBL1XR1 induces cell proliferation and inhibit cell apoptosis by the PI3K/AKT pathway in pancreatic ductal adenocarcinoma.
The GTPase and Rho GAP domains of p190, a tumor suppressor protein that binds the M(r) 120,000 Ras GAP, independently function as anti-Ras tumor suppressors.
The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells.
The GTPase Ran: regulation of cell life and potential roles in cell transformation.
The Human Minor Histocompatibility Antigen1 Is a RhoGAP.
The interferon-gamma-induced GTPase, mGBP-2, inhibits tumor necrosis factor alpha (TNF-alpha) induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-kappaB and Rac protein.
The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b.
The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
The microfilament system in the formation of invasive adhesions.
The mTOR pathway and its role in human genetic diseases.
The peptide recognized by HLA-A68.2-restricted, squamous cell carcinoma of the lung-specific cytotoxic T lymphocytes is derived from a mutated elongation factor 2 gene.
The primacy of ?1 integrin activation in the metastatic cascade.
The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis.
The R-enantiomer of ketorolac reduces ovarian cancer tumor burden in vivo.
The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells.
The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model.
The Rac3 GTPase in Neuronal Development, Neurodevelopmental Disorders, and Cancer.
The RagD GTPase Regulates mTORC1 Activity to Promote Tumor Growth.
The RAS-interacting chaperone UNC119 drives the RASSF6-MDM2-p53 axis and antagonizes RAS-mediated malignant transformation.
The Regulatory Mechanisms of Dynamin-Related Protein 1 in Tumor Development and Therapy.
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells.
The role of vascular endothelial growth factor, interleukin 8, and insulinlike growth factor in sustaining autophagic DIRAS3-induced dormant ovarian cancer xenografts.
The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation.
The Small Molecule BC-2059 Inhibits Wingless/Integrated (Wnt)-Dependent Gene Transcription in Cancer through Disruption of the Transducin ?-Like 1-?-Catenin Protein Complex.
The STAR of the DLC family.
The thyrotropin receptor (TSH-R) is not an oncogene for thyroid tumors: structural studies of the TSH-R and the alpha-subunit of Gs in human thyroid neoplasms.
The transcription factor GLI1 modulates the inflammatory response during pancreatic tissue remodeling.
The transforming activity of activated G alpha 12.
The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho.
The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) provokes a prolonged morphologic response and ERK activation in Tsc2-null renal tumor cells.
The tumor suppressor PP2A Abeta regulates the RalA GTPase.
The tumour promoter okadaic acid inhibits reticulocyte-lysate protein synthesis by increasing the net phosphorylation of elongation factor 2.
The UPR Transducer IRE1 Promotes Breast Cancer Malignancy by Degrading Tumor Suppressor microRNAs.
The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2.
Therapy: GTPase Ral-a new tumour target.
Transamidase site-targeted agents alter the conformation of the transglutaminase cancer stem cell survival protein to reduce GTP binding activity and cancer stem cell survival.
Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth.
Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction.
Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy.
Transducin (?)-like 1 X-linked receptor 1 correlates with clinical prognosis and clinicopathological characteristics in human solid carcinomas.
Transducin (Beta)-Like 1 X-Linked Receptor 1 Correlates with Clinical Prognosis and Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma.
Transducin ?-like 1 X-linked receptor 1 suppresses cisplatin sensitivity in nasopharyngeal carcinoma via activation of NF-?B pathway.
Transformation to small cell lung cancer and activation of KRAS during long-term erlotinib maintenance in a patient with non-small cell lung cancer: A case report.
Transgenic models of human cancer.
Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53.
Tsc2 expression increases the susceptibility of renal tumor cells to apoptosis.
TSH receptor and Gs-alpha gene mutations in the pathogenesis of toxic thyroid adenomas--a note of caution.
Tumor microenvironment and neurofibromatosis type I: connecting the GAPs.
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioblastoma cell chemotaxis via Lyn activation.
Tumor vasculature is a key determinant for the efficiency of nanoparticle-mediated siRNA delivery.
Two different pituitary adenomas in a patient with multiple endocrine neoplasia type 1 associated with growth hormone-releasing hormone-producing pancreatic tumor: clinical and genetic features.
Upregulation of LINC00659 expression predicts a poor prognosis and promotes migration and invasion of gastric cancer cells.
Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.
When RASSF1A RAN into tumor suppression: Ran GTPase is a RASSF1A effector involved in controlling microtubule organization.
Why does the Ras switch "break" by oncogenic mutations?
WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer.
Zoledronic acid inhibits TSC2-null cell tumor growth via RhoA/YAP signaling pathway in mouse models of lymphangioleiomyomatosis.
[Heterogeneity of GTPase-activating proteins for Ras in the regulation of Ras signal transduction pathway]
Nervous System Diseases
GTPase Regulator Associated with Focal Adhesion Kinase 1 (GRAF1) Immunoglobulin-Associated Ataxia and Neuropathy.
Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation.
The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1.
Neuralgia
Distinct roles of srGAP3-Rac1 in the initiation and maintenance phases of neuropathic pain induced by paclitaxel.
Inhibition of Mitochondrial Fission Protein Reduced Mechanical Allodynia and Suppressed Spinal Mitochondrial Superoxide Induced by Perineural Human Immunodeficiency Virus gp120 in Rats.
Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain.
Role of drp1, a key mitochondrial fission protein, in neuropathic pain.
Neurilemmoma
Actin-rich protrusions and nonlocalized GTPase activation in Merlin-deficient schwannomas.
Identification of recurrent regions of chromosome loss and gain in vestibular schwannomas using comparative genomic hybridisation.
Neuroacanthocytosis
Genomic organization of the human galpha14 and Galphaq genes and mutation analysis in chorea-acanthocytosis (CHAC).
Neuroblastoma
Activation of p21ras by nerve growth factor in neuroblastoma cells.
Activation of pertussis toxin-sensitive G-proteins in membranes of SH-SY5Y human neuroblastoma cells and bovine transducin by ethanol.
Alterations in the expression of G-proteins and regulation of adenylate cyclase in human neuroblastoma SH-SY5Y cells chronically exposed to low-efficacy mu-opioids.
Altered membrane NTPase activity in Lesch-Nyhan disease fibroblasts: comparison with HPRT knockout mice and HPRT-deficient cell lines.
Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates.
Bradykinin stimulates GTP hydrolysis in NG108-15 membranes by a high-affinity, pertussis toxin-insensitive GTPase.
Changing expression of GTPase activating proteins with differentiation in neuroblastoma.
Cholera toxin impairment of opioid-mediated inhibition of adenylate cyclase in neuroblastoma x glioma hybrid cells is due to a toxin-induced decrease in opioid receptor levels.
Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2.
Desensitization of D1 dopamine receptors down-regulates the Gs alpha subunit of G protein in SK-N-MC neuroblastoma cells.
Desensitization of opioid-stimulated GTPase in neuroblastoma x glioma hybrid cells.
Differential effects of suramin on the coupling of receptors to individual species of pertussis-toxin-sensitive guanine-nucleotide-binding proteins.
Effect of retinoic acid on p21ras and regulators of its activity in neuroblastoma.
Effects of beta-endorphin on mu and delta opioid receptor-coupled G-protein activity: low-Km GTPase studies.
Epac- and Ca2+ -controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors.
Equivalent regulation of wild type and an epitope-tagged variant of Gs alpha by the IP prostanoid receptor following expression in neuroblastoma x glioma hybrid, NG108-15, cells.
Estrogen induces neurite outgrowth via Rho family GTPases in neuroblastoma cells.
Ethanol differentially regulates G proteins in neural cells.
Genome wide transcriptomic analysis identifies pathways affected by the infusion of Clostridium perfringens culture supernatant in the duodenum of broilers in situ.
Identification of a rapidly dephosphorylating 95-kDa protein as elongation factor 2 during 8-Br-cAMP treatment of N1E115 neuroblastoma cells.
Identification of the critical domains of the delta-opioid receptor involved in G protein coupling using site-specific synthetic peptides.
Inhibition of ADP-ribosyltransferase increases synthesis of Gs alpha in neuroblastoma x glioma hybrid cells and reverses iloprost-dependent heterologous loss of fluoride-sensitive adenylate cyclase.
Interaction between optineurin and Rab1a regulates autophagosome formation in neuroblastoma cells.
Modulation of sodium-sensitive GTPase by partial opiate agonists. An explanation for the dual requirement for Na+ and GTP in inhibitory regulation of adenylate cyclase.
Novel bimodal effects of the G-protein tissue transglutaminase on adrenoreceptor signalling.
Opioid signal transduction in intact and fragmented SH-SY5Y neural cells.
Prostaglandin E1-mediated, cyclic AMP-independent, down-regulation of Gs alpha in neuroblastoma x glioma hybrid cells.
Quantitative stoichiometry of the proteins of the stimulatory arm of the adenylyl cyclase cascade in neuroblastoma x glioma hybrid, NG108-15 cells.
Regulation of cellular Gs alpha levels and basal adenylyl cyclase activity by expression of the beta 2-adrenoceptor in neuroblastoma cell lines.
Retinoic acid-induced differentiation of human neuroblastoma SH-SY5Y cells is associated with changes in the abundance of G proteins.
Selective activation of Galphao by D2L dopamine receptors in NS20Y neuroblastoma cells.
Thrombin stimulates pertussis toxin-sensitive and -insensitive GTPase activities and ADP-ribosylation of G(i) in human neuroblastoma SH-EP.
Vasoactive intestinal peptide-induced neurite remodeling in human neuroblastoma SH-SY5Y cells implicates the Cdc42 GTPase and is independent of Ras-ERK pathway.
Neurocutaneous Syndromes
Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis.
Neurodegenerative Diseases
Diverse roles of Rho family GTPases in neuronal development, survival, and death.
Downregualtion of dynamin-related protein 1 attenuates glutamate-induced excitotoxicity via regulating mitochondrial function in a calcium dependent manner in HT22 cells.
Elevated stimulatory and reduced inhibitory G protein alpha subunits in cerebellar cortex of patients with dominantly inherited olivopontocerebellar atrophy.
Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E2 receptor EP2 subtype.
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Ulk1 Governs Nerve Growth Factor/TrkA Signaling by Mediating Rab5 GTPase Activation in Porcine Hemagglutinating Encephalomyelitis Virus-Induced Neurodegenerative Disorders.
Neuroectodermal Tumors, Primitive
RABL6A Promotes Pancreatic Neuroendocrine Tumor Angiogenesis and Progression In Vivo.
Neurofibroma
Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy.
Neurofibromatoses
A functional assay for heterozygous mutations in the GTPase activating protein related domain of the neurofibromatosis type 1 gene.
Analysis of mutations and expression of GAP-related domain of the neurofibromatosis type 1 (NF1) gene in the progression of chronic myelogenous leukemia.
Antibody against neurofibromatosis type 1 gene product reacts with a triton-insoluble GTPase activating protein toward ras p21.
Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice.
Brain tumors predominantly express the neurofibromatosis type 1 gene transcripts containing the 63 base insert in the region coding for GTPase activating protein-related domain.
Differences in GTPase-activating protein activity between liver tumors and normal liver tissue in mice.
Differential regulation of rasGAP and neurofibromatosis gene product activities.
Differential splicing of the neurofibromatosis type-1 gene in the rat - splice variants homologous with the human are expressed in rat-cells.
Emergence and scattering of multiple neurofibromatosis (NF1)-related sequences during hominoid evolution suggest a process of pericentromeric interchromosomal transposition.
Enriched expression of NF1 in inhibitory neurons in both mouse and human brain.
Expression of the GTPase activating domain of the neurofibromatosis type 1 (NF1) gene in Escherichia coli and role of the conserved lysine residue.
Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP/PKA signaling defects in the Drosophila melanogaster neurofibromatosis-1 growth deficiency.
Heterogeneous amino acids in Ras and Rap1A specifying sensitivity to GAP proteins.
Inhibition of Ras/Raf interaction by anti-oncogenic mutants of neurofibromin, the neurofibromatosis type 1 (NF1) gene product, in cell-free systems.
Neurofibromatosis Type 1 Alternative Splicing is a Key Regulator of Ras Signaling in Neurons.
Neurofibromatosis: The role of guanosine triphosphatase activating proteins in sensory neuron function.
Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy.
Nf1 Regulates Alcohol Dependence-Associated Excessive Drinking and Gamma-Aminobutyric Acid Release in the Central Amygdala in Mice and Is Associated with Alcohol Dependence in Humans.
PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin.
Purification of a novel ras GTPase-activating protein from rat brain.
Regulation of Ras-GAP and the neurofibromatosis-1 gene product by eicosanoids.
Regulatory mechanisms for ras proteins.
Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells.
The GTPase stimulatory activities of the neurofibromatosis type 1 and the yeast IRA2 proteins are inhibited by arachidonic acid.
The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1.
Transgenic models of human cancer.
Neurofibromatosis 1
A functional assay for heterozygous mutations in the GTPase activating protein related domain of the neurofibromatosis type 1 gene.
A neurofibromatosis-1-regulated pathway is required for learning in Drosophila.
Analysis of mutations and expression of GAP-related domain of the neurofibromatosis type 1 (NF1) gene in the progression of chronic myelogenous leukemia.
Antibody against neurofibromatosis type 1 gene product reacts with a triton-insoluble GTPase activating protein toward ras p21.
Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice.
Brain tumors predominantly express the neurofibromatosis type 1 gene transcripts containing the 63 base insert in the region coding for GTPase activating protein-related domain.
Differences in GTPase-activating protein activity between liver tumors and normal liver tissue in mice.
Differential splicing of the neurofibromatosis type-1 gene in the rat - splice variants homologous with the human are expressed in rat-cells.
Effector domain mutations dissociate p21ras effector function and GTPase-activating protein interaction.
Emergence and scattering of multiple neurofibromatosis (NF1)-related sequences during hominoid evolution suggest a process of pericentromeric interchromosomal transposition.
Enriched expression of NF1 in inhibitory neurons in both mouse and human brain.
Expression of the GTPase activating domain of the neurofibromatosis type 1 (NF1) gene in Escherichia coli and role of the conserved lysine residue.
Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP/PKA signaling defects in the Drosophila melanogaster neurofibromatosis-1 growth deficiency.
Heterogeneous amino acids in Ras and Rap1A specifying sensitivity to GAP proteins.
Inhibition of Ras/Raf interaction by anti-oncogenic mutants of neurofibromin, the neurofibromatosis type 1 (NF1) gene product, in cell-free systems.
Mutations in the GAP-related domain impair the ability of neurofibromin to associate with microtubules.
Neurofibromatosis 1 gene (NF1) mutation is a rare genetic event in myelodysplastic syndrome regardless of the disease progression.
Neurofibromatosis Type 1 Alternative Splicing is a Key Regulator of Ras Signaling in Neurons.
Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy.
Nf1 Regulates Alcohol Dependence-Associated Excessive Drinking and Gamma-Aminobutyric Acid Release in the Central Amygdala in Mice and Is Associated with Alcohol Dependence in Humans.
PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin.
Purification of a novel ras GTPase-activating protein from rat brain.
Regulatory mechanisms for ras proteins.
Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells.
Somatic mutations in the neurofibromatosis 1 gene in human tumors.
The GTPase stimulatory activities of the neurofibromatosis type 1 and the yeast IRA2 proteins are inhibited by arachidonic acid.
The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1.
Neurofibrosarcoma
Combination therapies for MPNSTs targeting RABL6A-RB1 signaling.
Neuroinflammatory Diseases
G2019s LRRK2 promotes mitochondrial fission and increases TNF?-mediated neuroinflammation responses.
Neurologic Manifestations
CID1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke.
Neutropenia
Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia.
Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.
Newcastle Disease
Viral strategies for triggering and manipulating mitophagy.
Niemann-Pick Disease, Type C
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Niemann-Pick Diseases
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Night Blindness
A truncated form of rod photoreceptor PDE6 ?-subunit causes autosomal dominant congenital stationary night blindness by interfering with the inhibitory activity of the ?-subunit.
Autoantibodies to transducin in a patient with melanoma-associated retinopathy.
Characterization of rhodopsin congenital night blindness mutant T94I.
Coexistence of GNAT1 and ABCA4 variants associated with Nougaret-type congenital stationary night blindness and childhood-onset cone-rod dystrophy.
Loss of the effector function in a transducin-alpha mutant associated with Nougaret night blindness.
Missense mutation in the gene encoding the alpha subunit of rod transducin in the Nougaret form of congenital stationary night blindness.
Molecular genetics of Oguchi disease, fundus albipunctatus, and other forms of stationary night blindness: LVII Edward Jackson Memorial Lecture.
Molecular interactions and mutational impact upon rhodopsin (G90?D90) for hindering dark adaptation of eye: A comparative structural level outlook for signaling mechanism in night blindness.
Network and atomistic simulations unveil the structural determinants of mutations linked to retinal diseases.
Rod and cone function in the Nougaret form of stationary night blindness.
Non-alcoholic Fatty Liver Disease
The immunity-related GTPase M rs13361189 variant does not increase the risk for prevalent or incident steatosis; results from the Framingham Heart Study.
Variants in the autophagy-related gene IRGM confer susceptibility to non-alcoholic fatty liver disease by modulating lipophagy.
Noonan Syndrome
M-Ras/Shoc2 signaling modulates E-cadherin turnover and cell-cell adhesion during collective cell migration.
Obesity
Adiponectin Signaling and Impaired GTPase Rab5 Expression in Adipocytes of Adolescents with Obesity.
Association of fat mass and obesity-associated and retinitis pigmentosa guanosine triphosphatase (GTPase) regulator-interacting protein-1 like polymorphisms with body mass index in Chinese women.
Genome-wide analysis identifies colonic genes differentially associated with serum leptin and insulin concentrations in C57BL/6J mice fed a high-fat diet.
Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice.
Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level.
Rab18 dynamics in adipocytes in relation to lipogenesis, lipolysis and obesity.
Striatal Rgs4 regulates feeding and susceptibility to diet-induced obesity.
Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene.
Ocular Hypertension
Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E2 receptor EP2 subtype.
RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork.
Oculocerebrorenal Syndrome
Guanine nucleotide exchange factors activate Rab8a for Toll-like receptor signalling.
Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis.
Rab35 GTPase Triggers Switch-like Recruitment of the Lowe Syndrome Lipid Phosphatase OCRL on Newborn Endosomes.
Olfaction Disorders
The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia.
Optic Atrophy
De novo missense variant in the GTPase effector domain (GED) of DNM1L leads to static encephalopathy and seizures.
Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells.
Mitochondrial fusion proteins and human diseases.
Optic Atrophy, Autosomal Dominant
A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver.
Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells.
Mitochondrial oxidative phosphorylation in autosomal dominant optic atrophy.
Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin.
Mutation spectrum and splicing variants in the OPA1 gene.
OPA1 and cardiolipin team up for mitochondrial fusion.
OPA1 loss of function affects in vitro neuronal maturation.
OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L.
Opa1 Reduces Hypoxia-Induced Cardiomyocyte Death by Improving Mitochondrial Quality Control.
OPA1-associated disorders: Phenotypes and pathophysiology.
OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand.
Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation.
Optimized OPA1 Isoforms 1 and 7 Provide Therapeutic Benefit in Models of Mitochondrial Dysfunction.
Overexpression of optic atrophy 1 protein increases cisplatin resistance via inactivation of caspase-dependent apoptosis in lung adenocarcinoma cells.
Structural model of the OPA1 GTPase domain may explain the molecular consequences of a novel mutation in a family with autosomal dominant optic atrophy.
The mitochondrial inner membrane GTPase, Optic Atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity.
The mitochondrial permeability transition regulates cytochrome c release for apoptosis during endoplasmic reticulum stress by remodeling the cristae junction.
Ornithine Carbamoyltransferase Deficiency Disease
Identification of a cytogenetic deletion and of four novel mutations (Q69X, I172F, G188V, G197R) affecting the gene for ornithine transcarbamylase (OTC) in Spanish patients with OTC deficiency.
Symptoms of OTC deficiency but not DMD in a female carrier of an Xp21.1 deletion including the genes for dystrophin and OTC.
Osteoarthritis
Mitophagy in degenerative joint diseases.
Osteoma
Reduction in Gsalpha induces osteogenic differentiation in human mesenchymal stem cells.
Osteoporosis
Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E2 receptor EP2 subtype.
Osteosarcoma
A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro.
Activating GNAS mutations in parosteal osteosarcoma.
Identification of potential gene targets in systemic vasculitis using DNA microarray analysis.
RBEL1 is required for osteosarcoma cell proliferation via inhibiting retinoblastoma 1.
RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation.
ROCK2 mediates osteosarcoma progression and TRAIL resistance by modulating O-GlcNAc transferase degradation.
The Focal Adhesion-Localized CdGAP Regulates Matrix Rigidity Sensing and Durotaxis.
Ovarian Cysts
Recurrent ovarian cyst and mutation of the Gs alpha gene in ovarian cyst fluid cells: what is the link with McCune-Albright syndrome?
Ovarian Neoplasms
A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients.
An essential role for Ran GTPase in epithelial ovarian cancer cell survival.
An mDia2/ROCK signaling axis regulates invasive egress from epithelial ovarian cancer spheroids.
MiR-655-3p inhibited proliferation and migration of ovarian cancer cells by targeting RAB1A.
Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion.
The role of vascular endothelial growth factor, interleukin 8, and insulinlike growth factor in sustaining autophagic DIRAS3-induced dormant ovarian cancer xenografts.
Pancreatic Neoplasms
Allosteric modulation of Ras and the PI3K/AKT/mTOR pathway: emerging therapeutic opportunities.
ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer.
BART inhibits pancreatic cancer cell invasion by PKC? inactivation through binding to ANX7.
BART inhibits pancreatic cancer cell invasion by Rac1 inactivation through direct binding to active Rac1.
Cdc42 mediates cancer cell chemotaxis in perineural invasion.
Detection of KRAS Mutations in Circulating Tumor DNA by Digital PCR in Early Stages of Pancreatic Cancer.
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer.
Increased Ras GTPase activity is regulated by miRNAs that can be attenuated by CDF treatment in pancreatic cancer cells.
Multiple mechanisms involved in a low concentration of FL118 enhancement of AMR-MeOAc to induce pancreatic cancer cell apoptosis and growth inhibition.
Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways.
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice.
Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer.
Pancreatic cancer: modulation of KRAS, MicroRNAs, and intercellular communication in the setting of tumor heterogeneity.
Pro-migratory and TGF-?-activating functions of ?v?6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch.
RAN GTPase and Osteopontin in Pancreatic Cancer.
Ran GTPase protein promotes human pancreatic cancer proliferation by deregulating the expression of Survivin and cell cycle proteins.
Ran GTPase protein promotes metastasis and invasion in pancreatic cancer by deregulating the expression of AR and CXCR4.
Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and caveolin-1.
Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy.
Papilloma
The neurofibromatosis type 1 (Nf1) tumor suppressor is a modifier of carcinogen-induced pigmentation and papilloma formation in C57BL/6 mice.
Paralysis
Autonomously functioning thyroid nodule associated with thyrotoxic periodic paralysis.
Developmental stage- and tissue-specific expression of shibire, a Drosophila gene involved in endocytosis.
Structural characterization of ribosome recruitment and translocation by type IV IRES.
Paramyxoviridae Infections
Emerging views of mitophagy in immunity and autoimmune diseases.
Viral strategies for triggering and manipulating mitophagy.
Paraneoplastic Syndromes, Ocular
Autoantibodies to transducin in a patient with melanoma-associated retinopathy.
Cancer-retina antigens as potential paraneoplastic antigens in melanoma-associated retinopathy.
Paraplegia
Extremely severe complicated spastic paraplegia 3A with neonatal onset.
Parathyroid Neoplasms
Absence of mutations in the Gs alpha and Gi2 alpha genes in sporadic parathyroid adenomas and insulinomas.
Gs alpha--identification of a gene highly expressed by insulinoma and other endocrine tumors.
Parkinson Disease
Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides.
Allosteric modulation of the GTPase activity of a bacterial LRRK2 homologue by conformation-specific Nanobodies.
Alternative mitochondrial quality control mediated by extracellular release.
Andrographolide alleviates parkinsonism in MPTP-PD mice via targeting DRP1-mediated mitochondrial fission.
ARHGEF7 (BETA-PIX) Acts as Guanine Nucleotide Exchange Factor for Leucine-Rich Repeat Kinase 2.
Autophagy and LRRK2 in the Aging Brain.
Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities.
Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers.
Contribution of GTPase activity to LRRK2-associated Parkinson disease.
Elevated TYROBP expression predicts poor prognosis and high tumor immune infiltration in patients with low-grade glioma.
Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant.
Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants.
LRRK2 autophosphorylation enhances its GTPase activity.
LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.
LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease.
LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding.
LRRK2 pathobiology in Parkinson's disease - virtual inclusion.
LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate.
LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease.
Mitophagy in degenerative joint diseases.
Molecular Insights and Functional Implication of LRRK2 Dimerization.
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.
Phosphorylation of LRRK2 by casein kinase 1? regulates trans-Golgi clustering via differential interaction with ARHGEF7.
Rab1A Over-Expression Prevents Golgi Apparatus Fragmentation and Partially Corrects Motor Deficits in an Alpha-Synuclein Based Rat Model of Parkinson's Disease.
ROCO kinase activity is controlled by internal GTPase function.
S-Nitrosylation of DRP1 does not affect enzymatic activity and is not specific to Alzheimer's disease.
Supersensitization of neurochemical responses by L-DOPA and dopamine receptor agonists in the striatum of experimental Parkinson's disease model rats.
The dual enzyme LRRK2 hydrolyzes GTP in both its GTPase and kinase domains in vitro.
The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites.
The Role of LRRK2 in the Regulation of Monocyte Adhesion to Endothelial Cells.
X Caps the Phosphate for Phospho-Rab GTPase Recognition in Ciliogenesis and Parkinson's Disease.
Parkinsonian Disorders
Emerging views of mitophagy in immunity and autoimmune diseases.
Pediatric Obesity
Adiponectin Signaling and Impaired GTPase Rab5 Expression in Adipocytes of Adolescents with Obesity.
Pemphigus
Beyond steric hindrance: the role of adhesion signaling pathways in the pathogenesis of pemphigus.
Peripheral Nervous System Diseases
A cohort study of MFN2 mutations and phenotypic spectrums in Charcot-Marie-Tooth disease 2A patients.
Alterations of autophagy in the peripheral neuropathy Charcot-Marie-Tooth type 2B.
Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin.
Rab7 mutants associated with Charcot-Marie-Tooth disease cause delayed growth factor receptor transport and altered endosomal and nuclear signaling.
Rab7 mutants associated with Charcot-Marie-Tooth disease exhibit enhanced NGF-stimulated signaling.
Periventricular Nodular Heterotopia
Role of a heterotrimeric G-protein, Gi2, in the corticogenesis: possible involvement in periventricular nodular heterotopia and intellectual disability.
Peroxisomal Disorders
Peroxisomal disease cell lines with cellular plasmalogen deficiency have impaired muscarinic cholinergic signal transduction activity and amyloid precursor protein secretion.
Pheochromocytoma
Adrenergic pathways and left ventricular remodeling.
Cardioprotective effect of histamine H3-receptor activation: pivotal role of G beta gamma-dependent inhibition of voltage-operated Ca2+ channels.
Cytosolic Cl- Affects the Anticancer Activity of Paclitaxel in the Gastric Cancer Cell Line, MKN28 Cell.
Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade.
Evidence of the presence of GTPase inhibiting proteins for a low M(r) GTP-binding protein, ram p25, in rat spleen and pheochromocytoma PC12 cells.
Gs alpha--identification of a gene highly expressed by insulinoma and other endocrine tumors.
Induction of neurite extension and survival in pheochromocytoma cells by the Rit GTPase.
miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling.
miR-124-regulated RhoG: A conductor of neuronal process complexity.
Pituitary adenylate cyclase-activating polypeptide 38-mediated Rin activation requires Src and contributes to the regulation of HSP27 signaling during neuronal differentiation.
Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction-primer-introduced restriction analysis.
Relatively good prognosis of multiple endocrine neoplasia type 2B in Japanese: review of cases in Japan and analysis of genetic changes in tumors.
The influence of nerve growth factor on the activities of adenylate cyclase and high-affinity GTPase in pheochromocytoma PC12 cell.
The neuronal monoamine transporter VMAT2 is regulated by the trimeric GTPase Go(2).
The novel GTPase Rit differentially regulates axonal and dendritic growth.
Photophobia
Excised patches of plasma membrane from vertebrate rod outer segments retain a functional phototransduction enzymatic cascade.
Functional interchangeability of rod and cone transducin {alpha}-subunits.
Rethinking the role of phosducin: light-regulated binding of phosducin to 14-3-3 in rod inner segments.
The Heterotrimeric G-protein Complex Modulates Light Sensitivity in Arabidopsis thaliana Seed Germination.
Picornaviridae Infections
Linking Virus Discovery to Immune Responses Visualized during Zebrafish Infections.
Pituitary Neoplasms
A new constitutively activating mutation of the Gs protein alpha subunit-gsp oncogene is found in human pituitary tumours.
A pituitary specific point mutation of codon 201 of the Gs alpha gene in a pituitary adenoma of a patient with multiple endocrine neoplasia (MEN) type 1.
Activating mutations of the Gs alpha gene are associated with low levels of Gs alpha protein in growth hormone-secreting tumors.
Activating mutations of the stimulatory G protein in the McCune-Albright syndrome.
Analysis of the Gs alpha gene in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues.
Clinical and biochemical characteristics of acromegalic patients harboring gsp-positive and gsp-negative pituitary tumors.
Constitutively active Gs alpha is associated with an increased phosphodiesterase activity in human growth hormone-secreting adenomas.
Detection of gsp oncogene in growth hormone-secreting pituitary adenomas and the study of clinical characteristics of acromegalic patients with gsp-positive pituitary tumors.
Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-? interactions with G protein-?i and caveolin I.
G protein Gs alpha (GNAS 1), the probable candidate gene for Albright hereditary osteodystrophy, is assigned to human chromosome 20q12-q13.2.
Genomic sequence analysis of a key residue (Arg183) in human G alpha q in invasive non-functional pituitary adenomas.
Ghrelin mRNA and GH secretagogue receptor mRNA in human GH-producing pituitary adenomas is affected by mutations in the alpha subunit of G protein.
Glycoprotein hormone alpha-subunit production in somatotroph adenomas with and without Gs alpha mutations.
Growth hormone-prolactin-thyrotropin-secreting pituitary adenoma in atypical McCune-Albright syndrome with functionally normal Gs alpha protein.
Gs alpha and Gi2 alpha mutations in clinically non-functioning pituitary tumours.
Gs alpha mutation at codon 201 in pituitary adenoma causing gigantism in a 6-year-old boy with McCune-Albright syndrome.
GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours.
Hormonal signaling and pituitary adenomas.
Hydrolysis of GTP by the alpha-chain of Gs and other GTP binding proteins.
Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome.
Identification of G protein alpha subunit mutations in human growth hormone (GH)- and GH/prolactin-secreting pituitary tumors by single-strand conformation polymorphism (SSCP) analysis.
Long-acting peptidomimergic control of gigantism caused by pituitary acidophilic stem cell adenoma.
Markers of function and proliferation in non-invasive and invasive bi- and plurihormonal adenomas of patients with acromegaly: an immunohistochemical study.
Molecular biology of growth-hormone-secreting human pituitary tumours: biochemical consequences and potential clinical significance.
Molecular genetic studies of sporadic pituitary tumors.
Pituitary adenomas: screening for G alpha q mutations.
Prevalence of Gs alpha mutations in Korean patients with pituitary adenomas.
Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction-primer-introduced restriction analysis.
Transcriptional effects in GH3 cells of Gs alpha mutants associated with human pituitary tumors: stimulation of adenosine 3',5'-monophosphate response element-binding protein-mediated transcription and of prolactin and growth hormone promoter activity via protein kinase A.
[Pathophysiology and gene abnormalities of endocrine tumors]
Plague
The Yersinia pestis GTPase BipA Promotes Pathogenesis of Primary Pneumonic Plague.
Pneumonia
Divergent Evolution of Legionella RCC1 Repeat Effectors Defines the Range of Ran GTPase Cycle Targets.
Negative feedback on IL-23 exerted by IL-17A during pulmonary inflammation.
The Role of ExoS in Dissemination of Pseudomonas aeruginosa during Pneumonia.
Polycystic Kidney Diseases
Activator of G protein signaling 3 promotes epithelial cell proliferation in PKD.
Heterotrimeric G protein signaling in polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
ADPKD: a human disease altering Golgi function and basolateral exocytosis in renal epithelia.
Polycystic Ovary Syndrome
Colocalization of Polycystic Ovary Syndrome Candidate Gene Products in Theca Cells Suggests Novel Signaling Pathways.
Polyneuropathies
The Charcot-Marie Tooth Disease Mutation R94Q in MFN2 Decreases ATP Production but Increases Mitochondrial Respiration under Conditions of Mild Oxidative Stress.
Porcine Reproductive and Respiratory Syndrome
Viral strategies for triggering and manipulating mitophagy.
Pre-Eclampsia
Long non-coding HOTTIP regulates preeclampsia by inhibiting RND3.
Role of C825T polymorphism of GNbeta3 gene in preeclampsia.
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Forming megakaryocytes from murine-induced pluripotent stem cells by the inducible overexpression of supporting factors.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1.
Immunotoxins in cancer therapy: Review and update.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.
Progeria
A pathway linking oxidative stress and the Ran GTPase system in progeria.
Prolactinoma
Alteration of G alpha subunits mRNA levels in bromocriptine resistant prolactinomas.
Prostatic Neoplasms
A Rac1/Cdc42 GTPase-Specific Small Molecule Inhibitor Suppresses Growth of Primary Human Prostate Cancer Xenografts and Prolongs Survival in Mice.
CHC1-L, a candidate gene for prostate carcinogenesis at 13q14.2, is frequently affected by loss of heterozygosity and underexpressed in human prostate cancer.
Frequent Heterogeneous Missense Mutations of GGAP2 in Prostate Cancer: Implications for Tumor Biology, Clonality and Mutation Analysis.
Individual rac GTPases mediate aspects of prostate cancer cell and bone marrow endothelial cell interactions.
Inhibition of the GTPase Rac1 Mediates the Antimigratory Effects of Metformin in Prostate Cancer Cells.
Ligand-independent activation of androgen receptors by Rho GTPase signaling in prostate cancer.
Low expression of Galpha protein subunits in human prostate cancer.
MiR-221 promotes the development of androgen independence in prostate cancer cells via downregulation of HECTD2 and RAB1A.
Rho GTPases in PC-3 prostate cancer cell morphology, invasion and tumor cell diapedesis.
RhoC GTPase is required for PC-3 prostate cancer cell invasion but not motility.
SEC-induced activation of ANXA7 GTPase suppresses prostate cancer metastasis.
Small Molecule Inhibitors Targeting G?i2 Protein Attenuate Migration of Cancer Cells.
Supporting a Role for the GTPase Rab7 in Prostate Cancer Progression.
TBLR1 as an androgen receptor (AR) coactivator selectively activates AR target genes to inhibit prostate cancer growth.
The Arf-like GTPase Arl8b is essential for three-dimensional invasive growth of prostate cancer in vitro and xenograft formation and growth in vivo.
Type I collagen receptor (alpha2beta1) signaling promotes prostate cancer invasion through RhoC GTPase.
Protein Deficiency
G protein Gs alpha (GNAS 1), the probable candidate gene for Albright hereditary osteodystrophy, is assigned to human chromosome 20q12-q13.2.
Olfactory dysfunction in type I pseudohypoparathyroidism: dissociation from Gs alpha protein deficiency.
Pseudarthrosis
Hyperactive Ras/MAPK signaling is critical for tibial nonunion fracture in neurofibromin-deficient mice.
Pseudohypoparathyroidism
A 4-base pair deletion mutation of Gs alpha gene in a Japanese patient with pseudohypoparathyroidism.
A deletion hot-spot in exon 7 of the Gs alpha gene (GNAS1) in patients with Albright hereditary osteodystrophy.
A heterozygous 4-bp deletion mutation in the Gs alpha gene (GNAS1) in a patient with Albright hereditary osteodystrophy.
A new heterozygous mutation (D196N) in the Gs alpha gene as a cause for pseudohypoparathyroidism type IA in a boy who had gallstones.
A novel Gs alpha mutant in a patient with Albright hereditary osteodystrophy uncouples cell surface receptors from adenylyl cyclase.
Albright's hereditary osteodystrophy.
Characterization of a de novo 43-bp deletion of the Gs alpha gene (GNAS1) in Albright hereditary osteodystrophy.
Deficient erythrocyte membrane Gs alpha activity and resistance to trophic hormones of multiple endocrine organs in two cases of pseudohypoparathyroidism.
Distinct patterns of abnormal GNAS imprinting in familial and sporadic pseudohypoparathyroidism type IB.
G protein Gs alpha (GNAS 1), the probable candidate gene for Albright hereditary osteodystrophy, is assigned to human chromosome 20q12-q13.2.
Genetics of pseudohypoparathyroidism types Ia and Ic.
Growth hormone-releasing hormone resistance in pseudohypoparathyroidism type ia: new evidence for imprinting of the Gs alpha gene.
Identification of two novel deletion mutations within the Gs alpha gene (GNAS1) in Albright hereditary osteodystrophy.
Intracranial calcification and brachydactyly mimicking Albright's hereditary osteodystrophy in an adult patient with lingual thyroid and prolactinoma-like lesion.
Molecular characterization of a cryptic 2q37 deletion in a patient with Albright hereditary osteodystrophy-like phenotype.
Mutations in exon 7 of the GTP-binding protein Gs alpha were not a common cause of pseudohypoparathyroidism with Albright's hereditary osteodystrophy in Japanese.
Olfactory dysfunction in type I pseudohypoparathyroidism: dissociation from Gs alpha protein deficiency.
Parental origin of Gs alpha gene mutations in Albright's hereditary osteodystrophy.
Prevalence of three mutations in the Gs alpha gene among 24 families with pseudohypoparathyroidism type Ia.
Pseudohypoparathyroidism type Ia: two new heterozygous frameshift mutations in exons 5 and 10 of the Gs alpha gene.
Pseudohypoparathyroidism: new insight into Gs alpha.
Skeletal abnormalities and extra-skeletal ossification in mice with restricted Gsalpha deletion caused by a renin promoter-Cre transgene.
The stimulatory G protein alpha-subunit Gs alpha is imprinted in human thyroid glands: implications for thyroid function in pseudohypoparathyroidism types 1A and 1B.
Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene.
[G-proteins, their role in the transduction of the hormonal message and their pathology]
[Late onset epilepsy as the first symptom of pseudohypoparathyroidism]
Pseudopseudohypoparathyroidism
Albright's hereditary osteodystrophy.
Immunochemical analysis of the alpha-subunit of the stimulatory G-protein of adenylyl cyclase in patients with Albright's hereditary osteodystrophy.
Intracranial calcification and brachydactyly mimicking Albright's hereditary osteodystrophy in an adult patient with lingual thyroid and prolactinoma-like lesion.
Psoriasis
Role of Galphaq in pathogenesis of psoriasis, a new mechanism about the immune regulation in psoriasis.
Puberty, Precocious
Pubertal development in patients with McCune-Albright syndrome or pseudohypoparathyroidism.
Pulmonary Arterial Hypertension
Deletion of STAT5a/b in vascular smooth muscle abrogates the male bias in hypoxic pulmonary hypertension in mice: implications in the human disease.
Pulmonary Disease, Chronic Obstructive
HSP90AA1, ADRB2, TBL1XR1 and HSPB1 are chronic obstructive pulmonary disease-related genes that facilitate squamous cell lung cancer progression.
Pharmacological actions of statins: potential utility in COPD.
Q Fever
The Type IV Secretion System Effector Protein CirA Stimulates the GTPase Activity of RhoA and Is Required for Virulence in a Mouse Model of Coxiella burnetii Infection.
Rabies
Inhibition of opiate receptor-mediated signal transmission by rabies virus in persistently infected NG-108-15 mouse neuroblastoma-rat glioma hybrid cells.
Interferon-Inducible GTPase 1 Impedes the Dimerization of Rabies Virus Phosphoprotein and Restricts Viral Replication.
Interferon-inducible GTPase: a novel viral response protein involved in rabies virus infection.
Reperfusion Injury
Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury.
Protection of cardiomyocytes from the hypoxia-mediated injury by a Peptide targeting the activator of g-protein signaling 8.
RGS4, a GTPase activator, improves renal function in ischemia-reperfusion injury.
Respiratory Distress Syndrome
Extracellular vesicles released from p18 overexpressing pulmonary endothelial cells are barrier protective - potential implications for acute respiratory distress syndrome.
Retinal Degeneration
A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies.
A long-term efficacy study of gene replacement therapy for RPGR-associated retinal degeneration.
A novel form of transducin-dependent retinal degeneration: accelerated retinal degeneration in the absence of rod transducin.
Canine rod transducin alpha-1: cloning of the cDNA and evaluation of the gene as a candidate for progressive retinal atrophy.
Defective cone photoreceptor cytoskeleton, alignment, feedback, and energetics can lead to energy depletion in macular degeneration.
Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models.
Gypenosides attenuate retinal degeneration in a zebrafish retinitis pigmentosa model.
Immunological determination of transducin content in retinas exhibiting inherited degeneration.
Interaction of ciliary disease protein retinitis pigmentosa GTPase regulator with nephronophthisis-associated proteins in mammalian retinas.
More Than Meets the Eye: Current Understanding of RPGR Function.
Mutation analysis of the RPGR gene reveals novel mutations in south European patients with X-linked retinitis pigmentosa.
Mutations of RPGR in X-linked retinitis pigmentosa (RP3).
Overexpression of RPGR leads to male infertility in mice due to defects in flagellar assembly.
Probing Proteostatic Stress in Degenerating Photoreceptors Using Two Complementary In Vivo Reporters of Proteasomal Activity.
Reduced level of interphotoreceptor retinoid-binding protein (IRBP), a possible cause for retinal degeneration in the Abyssinian cat.
Restoration of RPGR expression in vivo using CRISPR/Cas9 gene editing.
Retinal accumulation of the phosducin/T beta gamma and transducin complexes in developing normal mice and in mice and dogs with inherited retinal degeneration.
Retinal degeneration in mice expressing the constitutively active G90D rhodopsin mutant.
Retinal Phenotype in the rd9 Mutant Mouse, a Model of X-Linked RP.
Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina: insights into X-linked Retinitis Pigmentosa and associated ciliopathies.
Rhodopsin accumulation at abnormal sites in retinas of mice with a human P23H rhodopsin transgene.
Retinal Diseases
Discordant Phenotypes in Fraternal Twins Having an Identical Mutation in Exon ORF15 of the RPGR Gene.
Exon screening of the genes encoding the beta- and gamma-subunits of cone transducin in patients with inherited retinal disease.
In Vivo CRISPR/Cas9-Mediated Genome Editing Mitigates Photoreceptor Degeneration in a Mouse Model of X-Linked Retinitis Pigmentosa.
Loss of RPGR glutamylation underlies the pathogenic mechanism of retinal dystrophy caused by TTLL5 mutations.
More Than Meets the Eye: Current Understanding of RPGR Function.
RPGR-Associated Retinal Degeneration in Human X-Linked RP and a Murine Model.
Retinal Dystrophies
Dark-light: model for nightblindness from the human rhodopsin Gly-90-->Asp mutation.
Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models.
Rd9 is a naturally occurring mouse model of a common form of retinitis pigmentosa caused by mutations in RPGR-ORF15.
Structural and functional plasticity of subcellular tethering, targeting and processing of RPGRIP1 by RPGR isoforms.
The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors.
The role of RPGR in cilia formation and actin stability.
The RPGRIP1-related retinal phenotype in children.
Retinitis
The retinal ciliopathies.
Retinitis Pigmentosa
A highly polymorphic RFLP marker in the canine retinitis pigmentosa GTPase regulator (RPGR) gene.
A large deletion in RPGR causes XLPRA in Weimaraner dogs.
A long-term efficacy study of gene replacement therapy for RPGR-associated retinal degeneration.
A new 2-base pair deletion in the RPGR gene in a black family with X-linked retinitis pigmentosa.
A NlaIII PCR/RFLP in an intron of the retinitis pigmentosa GTPase regulator gene (RPGR) on the canine X chromosome.
A novel de novo frameshift mutation of RPGR ORF15 is associated with X-linked retinitis pigmentosa in a Chinese family.
A novel homozygous truncating GNAT1 mutation implicated in retinal degeneration.
A novel missense mutation of RPGR identified from retinitis pigmentosa affects splicing of the ORF15 region and causes loss of transcript heterogeneity.
A novel mutation in retinitis pigmentosa GTPase regulator gene with a distinctive retinitis pigmentosa phenotype in a Chinese family.
A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3).
A screen for mutations in the transducin gene GNB1 in patients with autosomal dominant retinitis pigmentosa.
A single, abbreviated RPGR-ORF15 variant reconstitutes RPGR function in vivo.
Analysis of genes coding for S-antigen, interstitial retinol binding protein, and the alpha-subunit of cone transducin in patients with retinitis pigmentosa.
Arl3 and RP2 mediated assembly and traffic of membrane associated cilia proteins.
Arl3 and RP2 regulate the trafficking of ciliary tip kinesins.
ARL3 regulates trafficking of prenylated phototransduction proteins to the rod outer segment.
Association of a Novel Intronic Variant in RPGR With Hypomorphic Phenotype of X-Linked Retinitis Pigmentosa.
Association of fat mass and obesity-associated and retinitis pigmentosa guanosine triphosphatase (GTPase) regulator-interacting protein-1 like polymorphisms with body mass index in Chinese women.
Biochemical characterization and subcellular localization of the mouse retinitis pigmentosa GTPase regulator (mRpgr).
Canine RPGRIP1 mutation establishes cone-rod dystrophy in miniature longhaired dachshunds as a homologue of human Leber congenital amaurosis.
Characterization of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa. Mutations on the cytoplasmic surface affect transducin activation.
Characterization of Visual Function, Interocular Variability and Progression Using Static Perimetry-Derived Metrics in RPGR-Associated Retinopathy.
Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development.
Clinical and Electrophysiologic Characteristics of a Large Kindred with X-linked Retinitis Pigmentosa Associated with the RPGR Locus.
Clinical and genetic characteristics of 14 patients from 13 Japanese families with RPGR-associated retinal disorder: report of eight novel variants.
Codon-Optimized RPGR Improves Stability and Efficacy of AAV8 Gene Therapy in Two Mouse Models of X-Linked Retinitis Pigmentosa.
Complete exon-intron structure of the RPGR-interacting protein (RPGRIP1) gene allows the identification of mutations underlying Leber congenital amaurosis.
Complex expression pattern of RPGR reveals a role for purine-rich exonic splicing enhancers.
Comprehensive survey of mutations in RP2 and RPGR in patients affected with distinct retinal dystrophies: genotype-phenotype correlations and impact on genetic counseling.
Contiguous Xp11.4 Gene Deletion Leading to Ornithine Transcarbamylase Deficiency Detected by High-density Single-nucleotide Array.
Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated (FTO) and retinitis pigmentosa gtpase regulator interacting protein-1 like (RPGRIPIL) genes, and co-ordinates leptin receptor signaling.
Defective cone photoreceptor cytoskeleton, alignment, feedback, and energetics can lead to energy depletion in macular degeneration.
Detailed comparison of phenotype between male patients carrying variants in exons 1-14 and ORF15 of RPGR.
Development of a Reporter System to Explore MMEJ in the Context of Replacing Large Genomic Fragments.
Developmental and tissue expression of Xenopus laevis RPGR.
Discordant Phenotypes in Fraternal Twins Having an Identical Mutation in Exon ORF15 of the RPGR Gene.
Disease expression in X-linked retinitis pigmentosa caused by a putative null mutation in the RPGR gene.
Disease mechanisms of X-linked retinitis pigmentosa due to RP2 and RPGR mutations.
DNA sequence comparison of human and mouse retinitis pigmentosa GTPase regulator (RPGR) identifies tissue-specific exons and putative regulatory elements.
DNA Variant in the RPGRIP1L Gene Influences Alternative Splicing.
Dominant, gain-of-function mutant produced by truncation of RPGR.
Dose Range Finding Studies with Two RPGR Transgenes in a Canine Model of X-Linked Retinitis Pigmentosa Treated with Subretinal Gene Therapy.
Early-onset X-linked Retinitis Pigmentosa in a Heterozygous Female Harboring an Intronic Donor Splice Site Mutation in the Retinitis Pigmentosa GTPase Regulator Gene.
Evaluation of splicing efficiency in lymphoblastoid cell lines from patients with splicing-factor retinitis pigmentosa.
Evidence for RPGRIP1 gene as risk factor for primary open angle glaucoma.
Evolutionary Characterization of the Retinitis Pigmentosa GTPase Regulator Gene.
Exploring the Variable Phenotypes of RPGR Carrier Females in Assessing their Potential for Retinal Gene Therapy.
Expression and characterization of human PDEdelta and its Caenorhabditis elegans ortholog CEdelta.
Expression and localization of the ciliary disease protein retinitis pigmentosa GTPase regulator in mammalian kidney.
Fine mapping of canine XLPRA establishes homology of the human and canine RP3 intervals.
Functional characterization of the human RPGR proximal promoter.
Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models.
Gene replacement therapy rescues photoreceptor degeneration in a murine model of Leber congenital amaurosis lacking RPGRIP.
Gene Therapeutic Approach Using Mutation-adapted U1 snRNA to Correct a RPGR Splice Defect in Patient-derived Cells.
Gene therapy for the treatment of X-linked retinitis pigmentosa.
Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa.
Genetic analysis of Chinese families reveals a novel truncation allele of the retinitis pigmentosa GTPase regulator gene.
Genetic association of the gene encoding RPGRIP1L with susceptibility to vascular dementia.
Gypenosides attenuate retinal degeneration in a zebrafish retinitis pigmentosa model.
High Symmetry of Visual Acuity and Visual Fields in RPGR-Linked Retinitis Pigmentosa.
Homozygous females for a X-linked RPGR-ORF15 mutation in an Iranian family with retinitis pigmentosa.
Human retinopathy-associated ciliary protein Retinitis Pigmentosa GTPase Regulator (RPGR) regulates cilia-dependent vertebrate development.
Hypomorphism of Fto and Rpgrip1l causes obesity in mice.
Identification and characterization of a novel RPGR isoform in human retina.
Identification of a cytogenetic deletion and of four novel mutations (Q69X, I172F, G188V, G197R) affecting the gene for ornithine transcarbamylase (OTC) in Spanish patients with OTC deficiency.
Identification of a novel RPGR exon ORF15 mutation in a family with X-linked retinitis pigmentosa.
Identification of a novel RPGRIP1 mutation in an Iranian family with leber congenital amaurosis by exome sequencing.
Identification of novel RPGR (retinitis pigmentosa GTPase regulator) mutations in a subset of X-linked retinitis pigmentosa families segregating with the RP3 locus.
Identification of novel X-linked gain-of-function RPGR-ORF15 mutation in Italian family with retinitis pigmentosa and pathologic myopia.
Identification of proteins in retinas and IPM from eyes with retinitis pigmentosa.
In Vivo CRISPR/Cas9-Mediated Genome Editing Mitigates Photoreceptor Degeneration in a Mouse Model of X-Linked Retinitis Pigmentosa.
Insights into X-linked retinitis pigmentosa type 3, allied diseases and underlying pathomechanisms.
Interaction of ciliary disease protein retinitis pigmentosa GTPase regulator with nephronophthisis-associated proteins in mammalian retinas.
Interaction of retinitis pigmentosa GTPase regulator (RPGR) with RAB8A GTPase: implications for cilia dysfunction and photoreceptor degeneration.
Isolation of retinal proteins that interact with retinitis pigmentosa GTPase regulator by interaction trap screen in yeast.
Leber Congenital Amaurosis Caused by Mutations in RPGRIP1.
Limited proteolysis differentially modulates the stability and subcellular localization of domains of RPGRIP1 that are distinctly affected by mutations in Leber's congenital amaurosis.
Localizing the RPGR protein along the cilium: a new method to determine efficacies to treat RPGR mutations.
Loss of human disease protein retinitis pigmentosa GTPase regulator (RPGR) differentially affects rod or cone-enriched retina.
Loss of RPGR glutamylation underlies the pathogenic mechanism of retinal dystrophy caused by TTLL5 mutations.
Mapping of X-linked progressive retinal atrophy (XLPRA), the canine homolog of retinitis pigmentosa 3 (RP3).
Membrane protein transport in photoreceptors: the function of PDE?: the Proctor lecture.
Misexpression of the constitutive rpgrex1-19 variant leads to severe photoreceptor degeneration.
Modeling retinitis pigmentosa through patient-derived retinal organoids.
Molecular Strategies for RPGR Gene Therapy.
Molecular studies of phenotype variation in canine RPGR-XLPRA1.
Multimodal imaging of an RPGR carrier female.
Multiprotein Complexes of Retinitis Pigmentosa GTPase Regulator (RPGR), a Ciliary Protein Mutated in X-Linked Retinitis Pigmentosa (XLRP).
Muscular dystrophy in the Japanese Spitz: an inversion disrupts the DMD and RPGR genes.
Mutation analysis of the RPGR gene reveals novel mutations in south European patients with X-linked retinitis pigmentosa.
Mutational risk in highly repetitive exon ORF15 of the RPGR multidisease gene is not associated with haplotype background.
Mutations in DNAH5 account for only 15% of a non-preselected cohort of patients with primary ciliary dyskinesia.
Mutations in the X-linked retinitis pigmentosa genes RPGR and RP2 found in 8.5% of families with a provisional diagnosis of autosomal dominant retinitis pigmentosa.
Mutations of RPGR in X-linked retinitis pigmentosa (RP3).
Mutations that are a common cause of Leber congenital amaurosis in northern America are rare in Southern India.
Natural History Study of Retinal Structure, Progression, and Symmetry Using Ellipzoid Zone Metrics in RPGR-Associated Retinopathy.
Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin.
Novel Mutation in Retinitis Pigmentosa GTPase Regulator Gene Causes Primary Ciliary Dyskinesia and Retinitis Pigmentosa.
Novel mutations of RPGR in Chinese families with X-linked retinitis pigmentosa.
Novel mutations of RPGR in Chinese retinitis pigmentosa patients and the genotype-phenotype correlation.
Novel RPGR-ORF15 mutations in X-linked retinitis pigmentosa patients.
Novel variants of RPGR in X-linked retinitis pigmentosa families and genotype-phenotype correlation.
Overexpression of RPGR leads to male infertility in mice due to defects in flagellar assembly.
Pathogenesis of X-linked RP3: Insights from Animal Models.
Phenotypic variation and genotype-phenotype discordance in canine cone-rod dystrophy with an RPGRIP1 mutation.
Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein.
Population genetics of Cryptosporidium meleagridis in humans and birds: evidence for cross-species transmission.
Population haplotypes of exon ORF15 of the retinitis pigmentosa GTPase regulator gene in Germany : implications for screening for inherited retinal disorders.
Prenylation defects in inherited retinal diseases.
Protein networks and complexes in photoreceptor cilia.
QUANTITATIVE ANALYSIS OF HYPERAUTOFLUORESCENT RINGS TO CHARACTERIZE THE NATURAL HISTORY AND PROGRESSION IN RPGR-ASSOCIATED RETINOPATHY.
Quantitative Analysis of Retinal Structure Using Spectral-Domain Optical Coherence Tomography in RPGR-Associated Retinopathy.
Rd9 is a naturally occurring mouse model of a common form of retinitis pigmentosa caused by mutations in RPGR-ORF15.
Reliability and Repeatability of Cone Density Measurements in Patients With Stargardt Disease and RPGR-Associated Retinopathy.
Research progress on human genes involved in the pathogenesis of glaucoma (Review).
Restoration of RPGR expression in vivo using CRISPR/Cas9 gene editing.
Retinal Phenotype in the rd9 Mutant Mouse, a Model of X-Linked RP.
Retinal remodeling.
Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina: insights into X-linked Retinitis Pigmentosa and associated ciliopathies.
Retinitis pigmentosa GTPase regulator (RPGRr)-interacting protein is stably associated with the photoreceptor ciliary axoneme and anchors RPGR to the connecting cilium.
Rod and cone opsin mislocalization in an autopsy eye from a carrier of X-linked retinitis pigmentosa with a Gly436Asp mutation in the RPGR gene.
RPGR is mutated in patients with a complex X linked phenotype combining primary ciliary dyskinesia and retinitis pigmentosa.
RPGR isoform imbalance causes ciliary defects due to exon ORF15 mutations in X-linked retinitis pigmentosa (XLRP).
RPGR isoforms in photoreceptor connecting cilia and the transitional zone of motile cilia.
RPGR mutation analysis and disease: an update.
RPGR mutations might cause reduced orientation of respiratory cilia.
RPGR ORF15 Genotype and Clinical Variability of Retinal Degeneration in an Australian Population.
RPGR transcription studies in mouse and human tissues reveal a retina-specific isoform that is disrupted in a patient with X-linked retinitis pigmentosa.
RPGR-Associated Retinal Degeneration in Human X-Linked RP and a Murine Model.
RPGR-associated retinopathy: clinical features, molecular genetics, animal models and therapeutic options.
RPGR-containing protein complexes in syndromic and non-syndromic retinal degeneration due to ciliary dysfunction.
RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins.
RPGR: Its role in photoreceptor physiology, human disease, and future therapies.
RPGR: role in the photoreceptor cilium, human retinal disease, and gene therapy.
RPGRIP1 is essential for normal rod photoreceptor outer segment elaboration and morphogenesis.
RPGRIP1 is mutated in Leber congenital amaurosis: a mini-review.
RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis.
RpgrORF15 connects to the Usher protein network through direct interactions with multiple whirlin isoforms.
Screening for mutations in RPGR and RP2 genes in Jordanian families with X-linked retinitis pigmentosa.
Selective loss of RPGRIP1-dependent ciliary targeting of NPHP4, RPGR and SDCCAG8 underlies the degeneration of photoreceptor neurons.
Severe manifestations in carrier females in X linked retinitis pigmentosa.
Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and protein trafficking in the retina.
Species-specific subcellular localization of RPGR and RPGRIP isoforms: implications for the phenotypic variability of congenital retinopathies among species.
Spectrum of mutations in the RPGR gene that are identified in 20% of families with X-linked retinitis pigmentosa.
Structural and functional plasticity of subcellular tethering, targeting and processing of RPGRIP1 by RPGR isoforms.
Structure of a multipartite protein-protein interaction domain in splicing factor prp8 and its link to retinitis pigmentosa.
Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease.
Successful gene therapy in the RPGRIP1-deficient dog, a large model of cone-rod dystrophy.
Symptoms of OTC deficiency but not DMD in a female carrier of an Xp21.1 deletion including the genes for dystrophin and OTC.
The clinical application of preimplantation genetic diagnosis for X-linked retinitis pigmentosa.
The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the activity of the ubiquitin-proteasome system and protein biogenesis.
The human retinitis pigmentosa GTPase regulator gene variant database.
The interplay between RPGR, PDE? and Arl2/3 regulate the ciliary targeting of farnesylated cargo.
The Major Ciliary Isoforms of RPGR Build Different Interaction Complexes with INPP5E and RPGRIP1L.
The retinal ciliopathies.
The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors.
The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis.
The retinitis pigmentosa GTPase regulator interacting protein 1 (RPGRIP1) links RPGR to the nephronophthisis protein network.
The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase.
The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium.
The Role of RPGR and Its Interacting Proteins in Ciliopathies.
The role of RPGR in cilia formation and actin stability.
The RPGRIP1-related retinal phenotype in children.
The X-linked retinitis pigmentosa protein RP2 facilitates G protein traffic.
Three novel mutations of the RPGR gene exon ORF15 in three Japanese families with X-linked retinitis pigmentosa.
Toxicity and Efficacy Evaluation of an Adeno-Associated Virus Vector Expressing Codon-Optimized RPGR Delivered by Subretinal Injection in a Canine Model of X-linked Retinitis Pigmentosa.
Toxicology and Pharmacology of an AAV Vector Expressing Codon-Optimized RPGR in RPGR-Deficient Rd9 Mice.
Translational Read-Through Therapy of RPGR Nonsense Mutations.
Two novel mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene in X-linked retinitis pigmentosa (RP3). Mutations in brief no. 172. Online.
Two novel mutations of the retinitis pigmentosa GTPase regulator gene in two Chinese families with X-linked retinitis pigmentosa.
Upregulation of Mark3 and Rpgrip1 mRNA expression by jujuboside A in mouse hippocampus.
Use of induced pluripotent stem-cell technology to understand photoreceptor cytoskeletal dynamics in retinitis pigmentosa.
Versatile screening for binary protein-protein interactions by yeast two-hybrid mating.
X-linked retinitis pigmentosa in two families with a missense mutation in the RPGR gene and putative change of glycine to valine at codon 60.
X-linked retinitis pigmentosa: RPGR mutations in most families with definite X linkage and clustering of mutations in a short sequence stretch of exon ORF15.
Zebrafish Model for the Genetic Basis of X-Linked Retinitis Pigmentosa.
Retinoblastoma
Bidirectional regulation of c-fos promoter by an oncogenic gip2 mutant of G alpha i2. A novel implication of retinoblastoma gene product.
Combination therapies for MPNSTs targeting RABL6A-RB1 signaling.
Cone cell-specific genes expressed in retinoblastoma.
Expression of retina-specific genes by mouse retinoblastoma cells.
Rod photoreceptor-specific gene expression in human retinoblastoma cells.
Retinoschisis
Photoreceptor Pathology in the X-Linked Retinoschisis (XLRS) Mouse Results in Delayed Rod Maturation and Impaired Light Driven Transducin Translocation.
Rheumatic Heart Disease
Expression of the angiotensin II, rac GTPase activating protein 1, signal transducer and activator of transcription 3 signaling pathway in patients with permanent atrial fibrillation and rheumatic heart disease.
Rift Valley Fever
The interferon response circuit in antiviral host defense.
RNA Virus Infections
Respiratory syncytial virus strain A2 is resistant to the antiviral effects of type I interferons and human MxA.
Sarcoma
A barley SKP1-like protein controls abundance of the susceptibility factor RACB and influences the interaction of barley with the barley powdery mildew fungus.
Association of elongation factor 2 with ribosomes during growth of a murine ascitic tumor.
Detection of KRAS Mutations in Circulating Tumor DNA by Digital PCR in Early Stages of Pancreatic Cancer.
KRAS Mutations in Lung Cancer.
Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
Primary alveolar macrophages exposed to diesel particulate matter increase RAGE expression and activate RAGE signaling.
Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cells.
The use of protein-DNA, chromatin immunoprecipitation, and transcriptome arrays to describe transcriptional circuits in the dehydrated male rat hypothalamus.
Sarcoma, Avian
Infection of neuroretinal cells in vitro by avian sarcoma viruses UR1 and UR2: transformation, cell growth stimulation, and changes in transducin levels.
Partial sequence homologies between cytoskeletal proteins, c-myc, Rous sarcoma virus and adenovirus proteins, transducin, and beta- and gamma-crystallins.
Scoliosis
Hyperactive Ras/MAPK signaling is critical for tibial nonunion fracture in neurofibromin-deficient mice.
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Seizures
Brain region-specific and time-dependent decreases of G alpha i2 in amygdala-kindled rats.
De novo missense variant in the GTPase effector domain (GED) of DNM1L leads to static encephalopathy and seizures.
Loss of Cannabinoid CB 1 Receptors Induces Cortical Migration Malformations and Increases Seizure Susceptibility.
Sepsis
The GTPase Rab1 Is Required for NLRP3 Inflammasome Activation and Inflammatory Lung Injury.
[Role of immune-related GTPase M1 in cortical neurons autophagy of mice with sepsis-induced brain injury].
Sepsis-Associated Encephalopathy
Regulation of hippocampal neuronal apoptosis and autophagy in mice with sepsis-associated encephalopathy by immunity-related GTPase M1.
Shwachman-Diamond Syndrome
Cooperative energetic effects elicited by the yeast Shwachman-Diamond syndrome protein (Sdo1) and guanine nucleotides modulate the complex conformational landscape of the elongation factor-like 1 (Efl1) GTPase.
Defective Guanine Nucleotide Exchange in the Elongation Factor-like 1 (EFL1) GTPase by Mutations in the Shwachman-Diamond Syndrome Protein.
EFL1 mutations impair eIF6 release to cause Shwachman-Diamond syndrome.
Fluorescence Anisotropy as a Tool to Study Protein-protein Interactions.
Guanine nucleotide exchange in the ribosomal GTPase EFL1 is modulated by the protein mutated in the Shwachman-Diamond Syndrome.
Interaction of the GTPase Elongation Factor Like-1 with the Shwachman-Diamond Syndrome Protein and Its Missense Mutations.
Sleep Deprivation
Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction.
Small Cell Lung Carcinoma
Heterotrimeric G-protein, G?16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer.
Spastic Paraplegia, Hereditary
Atlastin GTPases are required for Golgi apparatus and ER morphogenesis.
Characterization of a novel SPG3A deletion in a French-Canadian family.
ER network formation and membrane fusion by atlastin1/SPG3A disease variants.
Homozygous mutation in Atlastin GTPase 1 causes recessive hereditary spastic paraplegia.
Loss of Dynamin 2 GTPase function results in microcytic anaemia.
Loss of the Mitochondrial Fission GTPase Drp1 Contributes to Neurodegeneration in a Drosophila Model of Hereditary Spastic Paraplegia.
Mutations in a newly identified GTPase gene cause autosomal dominant hereditary spastic paraplegia.
Novel mutation in the ATL1 with autosomal dominant hereditary spastic paraplegia presented as dysautonomia.
Novel mutation in the SPG3A gene in an African American family with an early onset of hereditary spastic paraplegia.
Pharmacologic rescue of axon growth defects in a human iPSC model of hereditary spastic paraplegia SPG3A.
SPG3A mutation screening in English families with early onset autosomal dominant hereditary spastic paraplegia.
Squamous Cell Carcinoma of Head and Neck
Immunohistochemical study of RhoC GTPase in oral squamous cell carcinoma.
Role of IQGAP1 in Papillomavirus-Associated Head and Neck Tumorigenesis.
Stargardt Disease
Mapping of the human cone transducin alpha-subunit (GNAT2) gene to 1p13 and negative mutation analysis in patients with Stargardt disease.
Reliability and Repeatability of Cone Density Measurements in Patients With Stargardt Disease and RPGR-Associated Retinopathy.
Starvation
Elongation factor 2 in the liver and skeletal muscle of mice is decreased by starvation.
Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals.
Heterotrimeric G protein mediated regulation of proteinase production in Aspergillus nidulans.
Lack of starvation-induced activation of AMP-activated protein kinase in the hypothalamus of the Lou/C rats resistant to obesity.
Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation.
Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance.
RGS4 controls G?i3-mediated regulation of Bcl-2 phosphorylation on TGN38-containing intracellular membranes.
SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.
Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.
TBC-2 is required for embryonic yolk protein storage and larval survival during L1 diapause in Caenorhabditis elegans.
The G-protein beta subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans.
The Interaction between the Ribosomal Stalk Proteins and Translation Initiation Factor 5B Promotes Translation Initiation.
The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae.
The ObgE/CgtA GTPase influences the stringent response to amino acid starvation in Escherichia coli.
The Small Yeast GTPase Rho5 and Its Dimeric GEF Dck1/Lmo1 Respond to Glucose Starvation.
Stomach Neoplasms
ALEX1, a novel tumor suppressor gene, inhibits gastric cancer metastasis via the PAR-1/Rho GTPase signaling pathway.
Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition of NF-kappaB activity and downregulation of PI3K/AKT/small GTPase signals.
Dichotomous roles of claudins as tumor promoters or suppressors: lessons from knockout mice.
Elevated expression of immunity-related GTPase family M in gastric cancer.
Expression analysis and implication of Rab1A in gastrointestinal relevant tumor.
Expression of two types of neurofibromatosis type 1 gene transcripts in gastric cancers and comparison of GAP activities.
Gallic acid inhibits gastric cancer cells metastasis and invasive growth via increased expression of RhoB, downregulation of AKT/small GTPase signals and inhibition of NF-?B activity.
IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL.
Long non?coding RNA lnc?GNAT1?1 inhibits gastric cancer cell proliferation and invasion through the Wnt/??catenin pathway in Helicobacter pylori infection.
Lysophosphatidic acid promotes cell invasion by up-regulating the urokinase-type plasminogen activator receptor in human gastric cancer cells.
Overexpression of Mitochondrial GTPase MFN2 Represents a Negative Prognostic Marker in Human Gastric Cancer and Its Inhibition Exerts Anti-Cancer Effects.
Prognosis Significance and Positive Correlation of Rab1A and p-S6K/Gli1 Expression in Gastric Cancer.
Rab1A knockdown represses proliferation and promotes apoptosis in gastric cancer cells by inhibition of mTOR/p70S6K pathway.
Rational design of small molecule RHOA inhibitors for gastric cancer.
Rho GTPases: Anti- or pro-neoplastic targets?
Significance and prognostic role of human epidermal growth factor receptor 2 and RAB1A expression in gastric cancer.
TBL1XR1 is involved in c-Met-mediated tumorigenesis of human nonsmall cell lung cancer.
Transducin (?)-like 1 X-linked receptor 1 promotes gastric cancer progression via the ERK1/2 pathway.
Stroke
Astrocyte-Derived Exosomes Treated With a Semaphorin 3A Inhibitor Enhance Stroke Recovery via Prostaglandin D2 Synthase.
Development of a cell transducible RhoA inhibitor TAT-C3 transferase and its encapsulation in biocompatible microspheres to promote survival and enhance regeneration of severed neurons.
Immune-related GTPase M (IRGM1) regulates neuronal autophagy in a mouse model of stroke.
Statin treatment before stroke reduces pro-inflammatory cytokine levels after stroke.
Synchronous tRNA movements during translocation on the ribosome are orchestrated by elongation factor G and GTP hydrolysis.
Tachycardia
HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes.
Tardive Dyskinesia
D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways.
Tauopathies
Photodynamic treatment modulates various GTPase and cellular signalling pathways in Tauopathy.
Teratocarcinoma
Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat.
Human septin 3 on chromosome 22q13.2 is upregulated by neuronal differentiation.
Regulation of the differentiation of teratocarcinoma cells into primitive endoderm by G alpha i2.
Retinoic acid stimulates protein kinase A-associated G proteins during human teratocarcinoma differentiation.
Transcriptional activation of Gs alpha expression by retinoic acid and parathyroid hormone-related protein in F9 teratocarcinoma cells.
Thrombocythemia, Essential
Concomitant presence of JAK2V617F mutation and BCR?ABL translocation in two patients: A new entity or a variant of myeloproliferative neoplasms (Case report).
Thrombocytopenia
Assessment of growth and differentiation processes in myelodysplastic syndromes by PCR analysis of Galpha16 and 5'-lipoxygenase.
Thrombosis
Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling.
G?13 Switch Region 2 Relieves Talin Autoinhibition to Activate ?IIb?3 Integrin.
Inside platelets...
Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis.
Rho GTPase regulation of reactive oxygen species generation and signalling in platelet function and disease.
[Effect of Dahuangzhechong pill on the gene expression spectra of preventing arterial thrombosis]
Thymoma
Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells.
Emergence of the Dedifferentiated Phenotype in Hepatocyte-Derived Tumors in Mice: Roles of Oncogene-Induced Epigenetic Alterations.
Thyroid Cancer, Papillary
EphB3 Stimulates Cell Migration and Metastasis in a Kinase-dependent Manner through Vav2-Rho GTPase Axis in Papillary Thyroid Cancer.
Next-generation sequencing identified somatic alterations that may underlie the etiology of Chinese papillary thyroid carcinoma.
Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction-primer-introduced restriction analysis.
Thyroid Neoplasms
Activating mutation in the stimulatory guanine nucleotide-binding protein in an infant with Cushing's syndrome and nodular adrenal hyperplasia.
An in vitro model of thyroid neoplasia: permanently transfected FRTL-5 cells with thyroglobulin promoter-cholera toxin A1 subunit minigene.
Constitutive activation of the Gs alpha protein-adenylate cyclase pathway may not be sufficient to generate toxic thyroid adenomas.
Diversity and prevalence of somatic mutations in the thyrotropin receptor and Gs alpha genes as a cause of toxic thyroid adenomas.
Expression of functional stimulatory guanine nucleotide binding protein in nonfunctioning thyroid adenomas is not correlated to adenylate cyclase activity and growth of these tumors.
Functioning and nonfunctioning thyroid adenomas involve different molecular pathogenetic mechanisms.
Gs alpha mutations in hyperfunctioning thyroid adenomas.
Low incidence of the stimulatory G protein alpha-subunit mutations in autonomously functioning thyroid adenomas in Japan.
Molecular aspects of the pathogenesis of nodular goiters, thyroid nodules and adenomas.
Prevalences of Gs alpha, ras, p53 mutations and ret/PTC rearrangement in differentiated thyroid tumours in a Korean population.
Structural studies of the thyrotropin receptor and Gs alpha in human thyroid cancers: low prevalence of mutations predicts infrequent involvement in malignant transformation.
Thyroid adenoma, Gs alpha expression and the cyclic adenosine monophosphate mitogenic cascade: a complex relationship.
Thyroid carcinoma in the McCune-Albright syndrome: contributory role of activating Gs alpha mutations.
Thyroid hyperfunctioning adenomas with and without Gsp/TSH receptor mutations show similar clinical features.
Toxic thyroid adenoma: absence of DNA mutations of the TSH receptor and Gs alpha.
[Thyroid carcinoma: genetics, diagnosis, clinical features, and surgical treatment]
Thyroid Nodule
Functioning and nonfunctioning thyroid adenomas involve different molecular pathogenetic mechanisms.
Somatic mutations in the thyrotropin receptor gene and not in the Gs alpha protein gene in 31 toxic thyroid nodules.
Tics
Constitutive activation of Myosin-dependent contractility sensitizes glioma tumor-initiating cells to mechanical inputs and reduces tissue invasion.
Tongue Neoplasms
Aberrant expression of RAB1A in human tongue cancer.
Tooth Diseases
The Charcot-Marie Tooth Disease Mutation R94Q in MFN2 Decreases ATP Production but Increases Mitochondrial Respiration under Conditions of Mild Oxidative Stress.
Toxoplasmosis
STAT1 plays a critical role in the regulation of antimicrobial effector mechanisms, but not in the development of Th1-type responses during toxoplasmosis.
transaldolase deficiency
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Triple Negative Breast Neoplasms
ARF1 regulates adhesion of MDA-MB-231 invasive breast cancer cells through formation of focal adhesions.
Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells.
Tuberculosis
Association between genetic variants in the IRGM gene and tuberculosis in a Korean population.
Association of autophagy-related IRGM polymorphisms with latent versus active tuberculosis infection in a Chinese population.
Autophagy as an immune defense mechanism.
Candidate biomarkers for discrimination between infection and disease caused by Mycobacterium tuberculosis.
Characterization of Ffh of Mycobacterium tuberculosis and its interaction with 4.5S RNA.
Cloning and characterization of engA, a GTP-binding protein from Mycobacterium tuberculosis H(37)Rv.
Cloning and characterization of GTP-binding proteins of Mycobacterium tuberculosis H(37)Rv.
Crystallization of the Mycobacterium tuberculosis cell-division protein FtsZ.
Human IRGM induces autophagy to eliminate intracellular mycobacteria.
Identification of a novel IRGM promoter single nucleotide polymorphism associated with tuberculosis.
Identification of Mycobacterium tuberculosis counterimmune (cim) mutants in immunodeficient mice by differential screening.
IFN-inducible GTPases in host cell defense.
IRGM gene polymorphisms and haplotypes associate with susceptibility of pulmonary tuberculosis in Chinese Hubei Han population.
Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling.
Mycobacterium tuberculosis PE31 (Rv3477) Attenuates Host Cell Apoptosis and Promotes Recombinant M. smegmatis Intracellular Survival via Up-regulating GTPase Guanylate Binding Protein-1.
Mycobacterium tuberculosis PE_PGRS20 and PE_PGRS47 Proteins Inhibit Autophagy by Interaction with Rab1A.
The C-terminally truncated MtFtsZ-DeltaC169 mutant of Mycobacterium tuberculosis FtsZ shows GTPase and GTP-induced, GTP-specific polymerization activities in vitro.
Tuberous Sclerosis
A novel missense mutation in the GTPase activating protein homology region of TSC2 in two large families with tuberous sclerosis complex.
Characterization of the intrinsic and TSC2-GAP-regulated GTPase activity of Rheb by real-time NMR.
Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2.
Molecular mechanisms through which amino acids mediate signaling through the mammalian target of rapamycin.
Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast.
Rap1 activity is elevated in malignant astrocytomas independent of tuberous sclerosis complex-2 gene expression.
Reciprocal Regulation of AMP-activated Protein Kinase and Phospholipase D.
Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex.
Rheb in neuronal degeneration, regeneration, and connectivity.
Sequence-specific 1H, 13C, and 15N backbone assignment of the activated 21 kDa GTPase rRheb.
Sequence-specific 1H, 13C, and 15N backbone assignment of the GTPase rRheb in its GDP-bound form.
Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region.
TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy.
The ERK and Akt Signaling Pathways Function Through Parallel Mechanisms to Promote mTORC1.
The Rheb family of GTP-binding proteins.
The RHEB-mTOR axis regulates expression of Tf2 transposons in fission yeast.
The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis.
TOR signaling.
Tsc2 expression increases the susceptibility of renal tumor cells to apoptosis.
Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease.
Urinary Bladder Neoplasms
Eight-plex iTRAQ labeling and quantitative proteomic analysis for human bladder cancer.
Expression of Rab1A in bladder cancer and its clinical implications.
Long Noncoding RNA MNX1 antisense RNA 1 Exerts Oncogenic Functions in Bladder Cancer by Regulating miR-218-5p/RAB1A Axis.
Mass spectroscopic phosphoprotein mapping of Ral binding protein 1 (RalBP1/Rip1/RLIP76).
Mitofusin 2 inhibits bladder cancer cell proliferation and invasion via the Wnt/?-catenin pathway.
The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis-activation and the consequent initiation of Rho GTPase-mediated signaling.
Urinary Retention
Urinary Retention, Incontinence, and Dysregulation of Muscarinic Receptors in Male Mice Lacking Mras.
Usher Syndromes
Detection of cone alpha transducin mRNA in human fetal cochlea: negative mutation analysis in Usher syndrome.
Uterine Cervical Neoplasms
BRIP1 inhibits the tumorigenic properties of cervical cancer by regulating RhoA GTPase activity.
The effect of RhoC siRNA on the invasiveness and proliferation of human cervical cancer cell line SiHa cells.
Vaccinia
Drosophila stimulatory G protein alpha subunit activates mammalian adenylyl cyclase but interacts poorly with mammalian receptors: implications for receptor-G protein interaction.
RAB1A promotes Vaccinia virus replication by facilitating the production of intracellular enveloped virions.
Rac-dependent and -independent pathways mediate growth factor-induced Ca2+ influx.
Vascular Diseases
Identification of novel signalling roles and targets for G(?) and G(??) downstream of the insulin-like growth factor 1 receptor in vascular smooth muscle cells.
Ventricular Dysfunction
Markedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure.
Vesicular Stomatitis
Conditional expression of type I interferon-induced bovine Mx1 GTPase in a stable transgenic vero cell line interferes with replication of vesicular stomatitis virus.
Enzymatic characterization of interferon-induced antiviral GTPases murine Mx1 and human MxA proteins.
Formation of guanosine(5')tetraphospho(5')adenosine cap structure by an unconventional mRNA capping enzyme of vesicular stomatitis virus.
GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex.
Rab1 and Ca2+ are required for the fusion of carrier vesicles mediating endoplasmic reticulum to Golgi transport.
Switch in antiviral specificity of a GTPase upon translocation from the cytoplasm to the nucleus.
The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3.
Virus Diseases
Alterations in G-protein-regulated transmembrane signalling induced in murine myocardium by coxsackievirus B3 infection.
Effects of immunostimulants targeting Ran GTPase on phagocytosis against virus infection in shrimp.
eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation.
Influenza Virus Induces Cholesterol-Enriched Endocytic Recycling Compartments for Budozone Formation via Cell Cycle-Independent Centrosome Maturation.
Interferon-inducible GTPase: a novel viral response protein involved in rabies virus infection.
Myxovirus resistance protein A activates type I IFN signaling pathway to inhibit zika virus replication.
Over-expression of GTP-binding proteins and GTPase activity in mouse astrocyte membranes in response to Theiler's murine encephalomyelitis virus infection.
Ran GTPase Regulates Hemocytic Phagocytosis of Shrimp by Interaction with Myosin.
Role of GTPase activity of murine Mx1 protein in nuclear localization and anti-influenza virus activity.
Small rho GTPases and cholesterol biosynthetic pathway intermediates in African swine fever virus infection.
Structural analysis of tumor-related single amino acid mutations in human MxA protein.
Whooping Cough
A cysteine-3 to serine mutation of the G-protein Gi1 alpha abrogates functional activation by the alpha 2A-adrenoceptor but not interactions with the beta gamma complex.
A Galphas protein-coupled membrane receptor, distinct from the classical oestrogen receptor, transduces rapid effects of oestradiol on [Ca2+]i in female rat distal colon.
A novel guanine nucleotide-binding protein coupled to the alpha 1-adrenergic receptor. II. Purification, characterization, and reconstitution.
A sensitive method for measuring neutralizing antibodies to Bordetella pertussis toxin: optimized ADP-ribosylation of transducin.
A specific beta gamma-subunit of transducin stimulates ADP-ribosylation of the alpha-subunit by pertussis toxin.
Acidification of serotonin-containing secretory vesicles induced by a plasma membrane calcium receptor.
Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat.
Activation of a pertussis-toxin-sensitive guanine-nucleotide-binding regulatory protein during desensitization of Dictyostelium discoideum cells to chemotactic signals.
Activation of Gi protein by peptide structures of the muscarinic M2 receptor second intracellular loop.
Activation of pertussis toxin-sensitive G-proteins in membranes of SH-SY5Y human neuroblastoma cells and bovine transducin by ethanol.
Activation of Syk in neutrophils by antineutrophil cytoplasm antibodies occurs via Fcgamma receptors and CD18.
Activation of the G(i) heterotrimeric G protein by ANCA IgG F(ab')2 fragments is necessary but not sufficient to stimulate the recruitment of those downstream mediators used by intact ANCA IgG.
Activation of the prostaglandin FP receptor in human granulosa cells.
ADP-ribosyl proteins formed by pertussis toxin are specifically cleaved by mercury ions.
ADP-ribosylarginine glycohydrolase catalyzing the release of ADP-ribose from the cholera toxin-modified alpha-subunits of GTP-binding proteins.
ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors.
ADP-ribosylation of transducin by pertussis toxin.
Agonist occupation of an alpha2A-adrenoreceptor-Gi1alpha fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-G protein activation stoichiometry.
Agonist-stimulated high-affinity GTPase in Dictyostelium membranes.
Aldosterone stimulation of GTP hydrolysis in membranes from renal epithelia.
Alpha 2-C10 adrenergic receptors expressed in rat 1 fibroblasts can regulate both adenylylcyclase and phospholipase D-mediated hydrolysis of phosphatidylcholine by interacting with pertussis toxin-sensitive guanine nucleotide-binding proteins.
Alpha2-adrenoceptor agonists stimulate high-affinity GTPase activity in a receptor subtype-selective manner.
Amino acid-specific ADP-ribosylation. Sensitivity to hydroxylamine of [cysteine(ADP-ribose)]protein and [arginine(ADP-ribose)]protein linkages.
Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.
Antibodies against the carboxyl-terminal 5-kDa peptide of the alpha subunit of transducin crossreact with the 40-kDa but not the 39-kDa guanine nucleotide binding protein from brain.
Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates.
Antibody-induced activation of beta1 integrin receptors stimulates cAMP-dependent migration of breast cells on laminin-5.
Antisense oligodeoxynucleotides to GS protein alpha-subunit sequence accelerate differentiation of fibroblasts to adipocytes.
Assignment of functional domains involved in ADP-ribosylation and B-oligomer binding within the carboxyl terminus of the S1 subunit of pertussis toxin.
Association of a solubilized prostaglandin E2 receptor from renal medulla with a pertussis toxin-reactive guanine nucleotide regulatory protein.
Association of heterotrimeric GTP binding regulatory protein (Go) with mitosis.
Association of two pertussis toxin-sensitive G-proteins with the D2-dopamine receptor from bovine striatum.
Bacterial lipopolysaccharide-stimulated GTPase activity in RAW 264.7 macrophage membranes.
Baculovirus expression and purification of a soluble, mutant G-protein alpha subunit.
Biochemical and biological activities of recombinant S1 subunit of pertussis toxin.
Biphasic regulation of adenylate cyclase by cholera toxin in neuroblastoma x glioma hybrid cells is due to the activation and subsequent loss of the alpha subunit of the stimulatory GTP binding protein (GS).
Block of light responses of salamander rods by pertussis toxin and reversal by nicotinamide.
Botulinum C2 toxin ADP-ribosylates actin.
Bradykinin stimulates GTP hydrolysis in NG108-15 membranes by a high-affinity, pertussis toxin-insensitive GTPase.
Bradykinin-activated transmembrane signals are coupled via No or Ni to production of inositol 1,4,5-trisphosphate, a second messenger in NG108-15 neuroblastoma-glioma hybrid cells.
C-terminal modifications of pertussis toxin-sensitive G-protein alpha-subunits differentially affect immunoreactivity. Evidence against endogenous ADP-ribosylation in human heart, lung, thrombocytes and adipose tissue.
Cardiac alpha 1-adrenoceptors stimulate a high-affinity GTPase activity in sarcolemmal membranes from rabbit atrial and ventricular myocytes.
Cardioprotection specific for the G protein Gi2 in chronic adrenergic signaling through beta 2-adrenoceptors.
Central G-alpha subunit protein-mediated control of cardiovascular function, urine output, and vasopressin secretion in conscious Sprague-Dawley rats.
Changes in cAMP formation in mononuclear leukocytes of heart and renal transplant recipients.
Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines.
Characterization of the membrane-associated GTPase activity: effects of chemotactic factors and toxins.
Characterization of the plasma membrane bound GTPase from rabbit neutrophils. I. Evidence for an Ni-like protein coupled to the formyl peptide, C5a, and leukotriene B4 chemotaxis receptors.
Characterization of transducin from bovine retinal rod outer segments. Use of monoclonal antibodies to probe the structure and function of the subunit.
Chemoattractant-induced activation of vacuolar H+ pumps and of an H(+)-selective conductance in neutrophils.
Chemoattractant-stimulated GTPase activity is decreased on membranes from polymorphonuclear leukocytes incubated in chemoattractant.
Chronic exposure of NG 108-15 cells to opiate agonists does not alter the amount of the guanine nucleotide-binding proteins Gi and Go.
Chronic exposure of rat glioma C6 cells to cholera toxin induces loss of the alpha-subunit of the stimulatory guanine nucleotide-binding protein (Gs).
Cloning and characterization of a cDNA coding for the alpha-subunit of a stimulatory G protein from Schistosoma mansoni.
Cloning and characterization of a G protein alpha-subunit-encoding gene from the basidiomycete, Coprinus congregatus.
Cloning of a molluscan G protein alpha subunit of the Gq class which is expressed differentially in identified neurons.
Colony-stimulating factor 1-induced Na+ influx into human monocytes involves activation of a pertussis toxin-sensitive GTP-binding protein.
Comparison of stimulation by chemotactic formyl peptide analogs between GTPase activity in neutrophil plasma membranes and granule enzyme release from intact neutrophils.
Concerted stimulation and deactivation of pertussis toxin-sensitive G proteins by chimeric G protein-coupled receptor-regulator of G protein signaling 4 fusion proteins: analysis of the contribution of palmitoylated cysteine residues to the GAP activity of RGS4.
Constitutive activation of NF-kappa B and secretion of interleukin-8 induced by the G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus involve G alpha(13) and RhoA.
Control of the expression and activity of the Galpha-interacting protein (GAIP) in human intestinal cells.
Coupling of oxytocin receptor to G proteins in rat myometrium during labor: Gi receptor interaction.
Coupling of TGF-beta-induced mitogenesis to G-protein activation in AKR-2B cells.
D2 dopamine receptors interact directly with N-type calcium channels and regulate channel surface expression levels.
Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Galpha(s) and Galpha(i)/Galpha(o) activation.
Different types of ADP-ribose protein bonds formed by botulinum C2 toxin, botulinum ADP-ribosyltransferase C3 and pertussis toxin.
Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL.
Differential complementation of a Neurospora crassa Galpha(i) mutation using mammalian Galpha protein genes.
Differential coupling of muscarinic m2 and m3 receptors to adenylyl cyclases V/VI in smooth muscle. Concurrent M2-mediated inhibition via Galphai3 and m3-mediated stimulation via Gbetagammaq.
Differential effects of lovastatin on mitogen induced calcium influx in human cultured vascular smooth muscle cells.
Direct activation of purified Go-type GTP binding protein by tricyclic antidepressants.
Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells.
Direct interactions of mastoparan and compound 48/80 with GTP-binding proteins.
Direct modulation of G-proteins by polyunsaturated fatty acids: a novel eicosanoid-independent regulatory mechanism in the developing lung.
Distinct cellular expression of pertussis toxin-sensitive GTP-binding proteins in rat cerebellum.
Distribution of the alpha-subunit of the guanine nucleotide-binding protein Gi2 and its comparison to G alpha o.
Effect of lysophosphatidic acid on motility, polarisation and metabolic burst of human neutrophils.
Effect of temperature and host factors on the activities of pertussis toxin and Bordetella adenylate cyclase.
Effect of tumor necrosis factor on GTP binding and GTPase activity in HL-60 and L929 cells.
Effector coupling of stably transfected human A3 adenosine receptors in CHO cells.
Effects of beta-endorphin on mu and delta opioid receptor-coupled G-protein activity: low-Km GTPase studies.
Effects of calcium on light-activated GTP-binding proteins in squid photoreceptor membranes.
Effects of eosinophils on mast cells: a new pathway for the perpetuation of allergic inflammation.
Effects of pertussis toxin-catalyzed ADP-ribosylation on interactions of transducin and the inhibitory GTP-binding protein of adenylate cyclase with guanyl nucleotides.
Effects of phosducin on the GTPase cycle of Go.
Effects of vasopressin-mastoparan chimeric peptides on insulin release and G-protein activity.
Endogenous regulator of G protein signaling proteins suppress Galphao-dependent, mu-opioid agonist-mediated adenylyl cyclase supersensitization.
Enhanced cyclic AMP responses in GH3 pituitary cells pretreated with muscarinic receptor agonists.
Enhanced detection of receptor constitutive activity in the presence of regulators of G protein signaling: applications to the detection and analysis of inverse agonists and low-efficacy partial agonists.
Entamoeba invadens contains the components of a classical adrenergic signaling system.
Epidermal growth factor receptor transactivation mediates substance P-induced mitogenic responses in U-373 MG cells.
Estrogen mediated inhibition of dopamine transport in the striatum: regulation by G alpha i/o.
Evidence for the presence of G-proteins, adenylyl cyclase and phospholipase C activities in lymphatic smooth muscle cell membranes.
Evidence for two GTPases activated by thrombin in membranes of human platelets.
Evidence that activation of a common G-protein by receptors for leukotriene B4 and N-formylmethionyl-leucyl-phenylalanine in HL-60 cells occurs by different mechanisms.
Expression and immunological properties of the five subunits of pertussis toxin.
Expression and molecular pharmacology of the mouse CRTH2 receptor.
Expression of GTP-binding proteins and protein kinase C isozymes in platelet-like particles derived from megakaryoblastic leukemia cells (MEG-01).
Expression of Plasmodium falciparum trimeric G proteins and their involvement in switching to sexual development.
Failure of [32P]ADP-ribosylation by pertussis toxin to determine Gi alpha content in membranes from various human tissues. Improved radioimmunological quantification using the 125I-labelled C-terminal decapeptide of retinal transducin.
Flow-mediated regulation of G-protein expression in cocultured vascular smooth muscle and endothelial cells.
Fluorescent labeling of signal-transducing G-proteins. Pertussis toxin-catalyzed etheno-ADP ribosylation of transducin.
Foetal-calf serum stimulates a pertussis-toxin-sensitive high-affinity GTPase activity in rat glioma C6 BU1 cells.
Functional alterations of G-proteins in diabetic rat retina: a possible explanation for the early visual abnormalities in diabetes mellitus.
Functional coupling of GABA(B) receptors with G proteins that are sensitive to N-ethylmaleimide treatment, suramin, and benzalkonium chloride in rat cerebral cortical membranes.
Functional coupling of mu-receptor-Galphai-tethered proteins in AtT20 cells.
Functional modifications of transducin induced by cholera or pertussis-toxin-catalyzed ADP-ribosylation.
G alpha q/11 mediates cholecystokinin activation of the cationic conductance in rat substantia nigra dopaminergic neurons.
G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha.
G protein beta gamma subunits. Simplified purification and properties of novel isoforms.
G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.
G protein coupling to M1 and M3 muscarinic receptors in sublingual glands.
G protein expression and second messenger formation in human granulosa cells.
G protein signaling from activated rat frizzled-1 to the beta-catenin-Lef-Tcf pathway.
G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation.
G protein-independent stimulation of human myocardial phospholipase C by mastoparan.
G proteins in Aplysia: biochemical characterization and regional and subcellular distribution.
G-protein betagamma subunit-dependent phosphorylation of 62-kDa protein in the early signaling pathway of starfish oocyte maturation induced by 1-methyladenine.
G-protein modulators alter the swimming behavior and calcium influx of Paramecium tetraurelia.
GABA(B) receptor-mediated stimulation of adenylyl cyclase activity in membranes of rat olfactory bulb.
Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac.
Granulocyte-macrophage colony-stimulating factor and human neutrophils: role of guanine nucleotide regulatory proteins.
GTP binding proteins: a key role in cellular communication.
GTP-binding proteins in luminal and basolateral membranes from pars convoluta and pars recta of rabbit kidney proximal tubule.
Guanine nucleotide regulation of the pertussis and cholera toxin substrates of rat glioma C6 BU1 cells.
Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.
Heat stress stimulates high affinity GTPase in cervical carcinoma cells.
Heterotrimeric G proteins containing G alpha i3 regulate multiple effector enzymes in the same cell. Activation of phospholipases C and A2 and inhibition of adenylyl cyclase.
Heterotrimeric Galphaq11 co-immunoprecipitates with surface-anchored GRP78 from plasma membranes of alpha2M*-stimulated macrophages.
Hormonal regulation of Gi2 alpha-subunit phosphorylation in intact hepatocytes.
Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits.
Human 5-HT1A receptor expressed in insect cells activates endogenous G(o)-like G protein(s).
Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor.
Identification of a protein hydrolysate responsive G protein-coupled receptor in enterocytes.
Identification of a second putative receptor of platelet-activating factor from human polymorphonuclear leukocytes.
Identification of a structural element in phospholipase C beta2 that interacts with G protein betagamma subunits.
Identification of G-proteins in rat parotid gland plasma membranes and granule membranes: presence of distinct components in granule membranes.
Identification of guanine nucleotide binding regulatory proteins in bovine tracheal smooth muscle.
IgE-Independent Activation of Human Mast Cells Indicates their Role in the Late Phase Reaction of Allergic Inflammation.
Immunochemical detection of GTP-binding protein in cephalopod photoreceptors by anti-peptide antibodies.
Immunochemical detection of guanine nucleotide binding proteins mono-ADP-ribosylated by bacterial toxins.
Immunochemical evidence for a novel pertussis toxin substrate in human neutrophils.
Immunological and biochemical differentiation of guanyl nucleotide binding proteins: interaction of Go alpha with rhodopsin, anti-Go alpha polyclonal antibodies, and a monoclonal antibody against transducin alpha subunit and Gi alpha.
Immunological characterization of guanine nucleotide-binding proteins: effects of a monoclonal antibody against the gamma subunit of transducin on guanine nucleotide-binding protein-receptor interactions.
Improved purification of transducin subunits from bovine retinal rod outer segments.
Inhibition by pertussis toxin of guanyl nucleotides exchange on transducin in bovine rod cell membranes.
Inhibition of bovine rod outer segment GTPase by Bordetella pertussis toxin.
Inhibition of the GTPase activity of transducin by an NAD+:arginine ADP-ribosyltransferase from turkey erythrocytes.
Inhibition of voltage-dependent Ca2+ currents and activation of pertussis toxin-sensitive G-proteins via muscarinic receptors in GH3 cells.
Insulin stimulates a novel GTPase activity in human platelets.
Interaction of small G proteins with photoexcited rhodopsin.
Interaction of substance P, compound 48/80 and mastoparan with the alpha-subunit C-terminus of G protein.
Interactions of phosducin with defined G protein beta gamma-subunits.
Interactions of the alpha2A-adrenoceptor with multiple Gi-family G-proteins: studies with pertussis toxin-resistant G-protein mutants.
Involvement of G protein betagamma-subunits in diverse signaling induced by G(i/o)-coupled receptors: study using the Xenopus oocyte expression system.
Involvement of N-myristoylation in monoclonal antibody recognition sites on chimeric G protein alpha subunits.
Involvement of signal transducing GTP-binding proteins in renal artery alpha 1-adrenoceptor mediated smooth muscle contraction.
Islet-activating protein impairs alpha 2-adrenoceptor-mediated inhibitory regulation of human platelet adenylate cyclase.
Islet-activating protein prevents nicotinic acid-induced GTPase stimulation and GTP but not GTP gamma S-induced adenylate cyclase inhibition in rat adipocytes.
Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.
Kaposi sarcoma-associated herpes virus (KSHV) G protein-coupled receptor (vGPCR) activates the ORF50 lytic switch promoter: a potential positive feedback loop for sustained ORF50 gene expression.
Khellin, but not 8-methoxypsoralen, inhibits adenylyl cyclase system in HeLa cells.
Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane.
Light activation of phosphatidylethanolamine N-methyltransferase in rod outer segments and its modulation by association states of transducin.
Light activation of phospholipase A2 in rod outer segments of bovine retina and its modulation by GTP-binding proteins.
Lipid modification at the N terminus of photoreceptor G-protein alpha-subunit.
Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins.
Localization of a region of the S1 subunit of pertussis toxin required for efficient ADP-ribosyltransferase activity.
Luteinizing hormone/choriogonadotropin-dependent, cholera toxin-catalyzed adenosine 5'-diphosphate (ADP)-ribosylation of the long and short forms of Gs alpha and pertussis toxin-catalyzed ADP-ribosylation of Gi alpha*.
Lymphocytes in the peritoneum home to the omentum and are activated by resident dendritic cells.
Mannose 6-phosphate/insulin-like growth factor II receptor fails to interact with G-proteins. Analysis of mutant cytoplasmic receptor domains.
Mastoparan interacts with the carboxyl terminus of the alpha subunit of Gi.
Measurement of agonist efficacy using an alpha2A-adrenoceptor-Gi1alpha fusion protein.
Metabotropic glutamate receptor analogues inhibit p[NH]ppG-stimulated phospholipase C activity in bovine brain coated vesicles: involvement of a pertussis toxin-sensitive G-protein.
Modification of cysteine residues within G(o) and other neuronal proteins by exposure to nitric oxide.
Modification of the amounts of G proteins and of the activity of adenylyl cyclase in human benign thyroid tumours.
Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a.
Modulation of guanosine triphosphatase activity of G proteins by arachidonic acid in rat Leydig cell membranes.
Molecular characterization of the in vitro activation of pertussis toxin by ATP.
Molecular cloning and expression of two melanin-concentrating hormone receptors in goldfish.
Molecular interaction of the human alpha 2-C10-adrenergic receptor, when expressed in Rat-1 fibroblasts, with multiple pertussis toxin-sensitive guanine nucleotide-binding proteins: studies with site-directed antisera.
Mono(ADP-ribosylation) in rat liver mitochondria.
Mu-type opioid receptors in rat periaqueductal gray-enriched P2 membrane are coupled to guanine nucleotide binding proteins.
Muscarinic cholinergic-receptor stimulation of specific GTP hydrolysis related to adenylate cyclase activity in canine cardiac sarcolemma.
Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity.
N-Formyl peptide receptor ligation induces rac-dependent actin reorganization through Gbeta gamma subunits and class Ia phosphoinositide 3-kinases.
Na+ regulation of formyl peptide receptor-mediated signal transduction in HL 60 cells. Evidence that the cation prevents activation of the G-protein by unoccupied receptors.
Neutrophil activation by inflammatory microcrystals of monosodium urate monohydrate utilizes pertussis toxin-insensitive and -sensitive pathways.
Nod factors activate both heterotrimeric and monomeric G-proteins in Vigna unguiculata (L.) Walp.
Nucleotide exchange and cGMP phosphodiesterase activation by pertussis toxin inactivated transducin.
Opioid receptors are coupled tightly to G proteins but loosely to adenylate cyclase in NG108-15 cell membranes.
Opposite coupling of prostaglandin E receptor EP3C with Gs and G(o). Stimulation of Gs and inhibition of G(o).
Pancreastatin activates pertussis toxin-sensitive guanylate cyclase and pertussis toxin-insensitive phospholipase C in rat liver membranes.
Pancreastatin receptor is coupled to a guanosine triphosphate-binding protein of the G(q/11)alpha family in rat liver membranes.
Pertussis toxin inhibition of B cell and macrophage responses to bacterial lipopolysaccharide.
Pertussis toxin inhibition of chemotaxis and the ADP-ribosylation of a membrane protein in a human-mouse hybrid cell line.
Pertussis toxin inhibits enkephalin stimulation of GTPase of NG108-15 cells.
Pertussis toxin inhibits induction of human immunodeficiency virus type 1 in infected monocytes.
Pertussis toxin reverses the inhibition of the adenylyl cyclase system by khellin in HeLa cells.
Pertussis toxin treatment increases glutamate release and dihydropyridine binding sites in cultured rat cerebellar granule neurons.
Pertussis toxin-catalyzed ADP-ribosylation of transducin. Cysteine 347 is the ADP-ribose acceptor site.
Pharmacological and biochemical characterization of dopamine receptors mediating stimulation of a high affinity GTPase in rat striatum.
Phototransduction cascade and circadian oscillator in chicken pineal gland.
Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni.
Platelet activating factor stimulates a receptor-coupled membrane GTPase in guinea pig eosinophils.
Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis.
Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase.
Possible Involvement of Sphingosine-1-Phosphate/G(i)/RhoA Pathways in Adherence of Eosinophils to Pulmonary Endothelium.
Preactivation permits subsequent stimulation of phospholipase C by G(i)-coupled receptors.
Pregnancy switches adrenergic signal transduction in rat and human uterine myocytes as probed by BKCa channel activity.
Primary and secondary structure of bovine retinal S antigen (48-kDa protein).
Priming effects of granulocyte-macrophage colony-stimulating factor are coupled to cholera toxin-sensitive guanine nucleotide binding protein in human T lymphocytes.
Prolonged activation of extracellular signal-regulated kinase by a protein kinase C-dependent and N17Ras-insensitive mechanism mediates the proliferative response of G(i/o)-coupled somatostatin sst(4) receptors.
Properties of a novel GTP-binding protein which is associated with soluble phosphoinositides-specific phospholipase C.
Protein-tyrosine phosphatase SHP2 is positively linked to proteinase-activated receptor 2-mediated mitogenic pathway.
Purification and characterization of transducin from capybara Hydrochoerus hydrochaeris.
Purification and G protein subunit regulation of a phospholipase C-beta from Xenopus laevis oocytes.
Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase.
Quantification of Gi alpha-proteins in the failing and nonfailing human myocardium.
Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway.
Rat somatostatin receptor type 1 couples to G proteins and inhibition of cyclic AMP accumulation.
Reconstitution of the purified porcine atrial muscarinic acetylcholine receptor with purified porcine atrial inhibitory guanine nucleotide binding protein.
Reduction of adenylyl cyclase activity by cholera toxin in myeloid cells. Long-term down-regulation of Gs alpha subunits by cholera toxin treatment.
Regulation of G protein activation and effector modulation by fusion proteins between the human 5-hydroxytryptamine(1A) receptor and the alpha subunit of G(i1): differences in receptor-constitutive activity imparted by single amino acid substitutions in G(i1)alpha.
Regulation of GTPase and adenylate cyclase activity by amyloid beta-peptide and its fragments in rat brain tissue.
Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions.
Regulation of retinal cGMP cascade by phosducin in bovine rod photoreceptor cells. Interaction of phosducin and transducin.
Requirement of Galphai in thymic homing and early T cell development.
Requirement of Gbetagamma and c-Src in D2 dopamine receptor-mediated nuclear factor-kappaB activation.
Requirement of phosphatidylinositol 3-kinase activity for bradykinin stimulation of NF-kappaB activation in cultured human epithelial cells.
Role of altered G-protein expression in the regulation of myocardial adenylate cyclase activity and force of contraction in spontaneous hypertensive cardiomyopathy in rats.
Role of carboxylmethylation in chemoattractant receptor-stimulated G protein activation and functional responses.
Role of G protein beta gamma subunits in the regulation of the plasma membrane Ca2+ pump.
Role of guanine nucleotide regulatory proteins and inositol phosphates in the hormone induced mobilization of hepatocyte calcium.
Role of histidine 35 of the S1 subunit of pertussis toxin in the ADP-ribosylation of transducin.
Roles of heterotrimeric and monomeric G proteins in sperm-induced activation of mouse eggs.
Secretion-stimulating and secretion-inhibiting hormones stimulate high-affinity pertussis-toxin-sensitive GTPases in membranes of a pituitary cell line.
Selective reconstitution of gastrin-releasing peptide receptor with G alpha q.
Signal-dependent translocation of transducin, RGS9-1-Gbeta5L complex, and arrestin to detergent-resistant membrane rafts in photoreceptors.
Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP.
Solubilization of the vasopressin receptor from rat liver plasma membranes. Evidence for a receptor X GTP-binding protein complex.
Sphingosine 1-phosphate stimulates G(i)- and Rho-mediated vascular endothelial cell spreading and migration.
Sphingosine-1-phosphate-induced oxygen free radical generation in smooth muscle cell migration requires Galpha12/13 protein-mediated phospholipase C activation.
Spontaneous association between opioid receptors and GTP-binding regulatory proteins in native membranes: specific regulation by antagonists and sodium ions.
Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of transducin and its inhibition by the alpha subunit.
Stimulation of the T-cell receptors CD3 and CD2 with OKT3 and OKT11 antibodies activates a common pertussis toxin-insensitive G-protein.
Stimulation of the thiol-dependent ADP-ribosyltransferase and NAD glycohydrolase activities of Bordetella pertussis toxin by adenine nucleotides, phospholipids, and detergents.
Stimulatory and inhibitory guanine-nucleotide-binding regulatory protein involvement in stimulation of arachidonic-acid release by N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor from guinea-pig alveolar macrophages. Differential receptor/G-protein interaction assessed by pertussis and cholera toxins.
Stromal cell-derived factor-1-induced LFA-1 activation during in vivo migration of T cell hybridoma cells requires Gq/11, RhoA, and myosin, as well as Gi and Cdc42.
Structural and functional relationships of guanosine triphosphate binding proteins.
Structural requirements for G(o) activation by receptor-derived peptides: activation and modulation domains of the alpha 2-adrenergic receptor i3c region.
Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein.
Subcellular localization and kinetic characterization of guanine nucleotide binding proteins in normal rat and human pancreatic islets and transformed beta cells.
Subcellular localization of Gi alpha in human neutrophils.
Substance P evokes cation currents through TRP channels in HEK293 cells.
Supersensitivity to mu-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Galpha protein subunits.
Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway.
Synthesis and characterization of fluorescently labeled bovine brain G protein subunits.
The alpha subunit of Gq contributes to muscarinic inhibition of the M-type potassium current in sympathetic neurons.
The beta6/alpha5 regions of Galphai2 and GalphaoA increase the promiscuity of Galpha16 but are insufficient for pertussis toxin-catalyzed ADP-ribosylation.
The Ca2+-dependent binding of calmodulin to an N-terminal motif of the heterotrimeric G protein beta subunit.
The Ca2+-sensing receptor couples to Galpha12/13 to activate phospholipase D in Madin-Darby canine kidney cells.
The carboxyl terminus of the S1 subunit of pertussis toxin confers high affinity binding to transducin.
The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein.
The function but not the expression of rat liver inhibitory guanine nucleotide binding protein is altered in streptozotocin-induced diabetes.
The G protein beta gamma subunit transduces the muscarinic receptor signal for Ca2+ release in Xenopus oocytes.
The G proteins of the G alpha i and G alpha q family couple the bradykinin receptor to the release of endothelium-derived relaxing factor.
The glutamate-receptor linked cGMP cascade of retinal on-bipolar cells is pertussis and cholera toxin-sensitive.
The guanine-nucleotide-binding protein subunit G alpha i2 is involved in calcium activation of phospholipase A2. Effects of the dominant negative G alpha i2 mutant, [G203T]G alpha i2, on activation of phospholipase A2 in Chinese hamster ovary cells.
The heterotrimeric G protein G alpha i2 mediates lysophosphatidic acid-stimulated induction of the c-fos gene in mouse fibroblasts.
The heterotrimeric G-protein Gi is localized to the insulin secretory granules of beta-cells and is involved in insulin exocytosis.
The human S100 protein MRP-14 is a novel activator of the beta 2 integrin Mac-1 on neutrophils.
The inhibition of neutrophil granule enzyme secretion and chemotaxis by pertussis toxin.
The kyotorphin (tyrosine-arginine) receptor and a selective reconstitution with purified Gi, measured with GTPase and phospholipase C assays.
The presence of a heterotrimeric G protein and its role in signal transduction of extracellular calmodulin in pollen germination and tube growth
The purification of a guanine nucleotide regulatory protein from rat brain membrane and the measurement of its GTPase.
The regulator of G protein signaling RGS4 selectively enhances alpha 2A-adreoreceptor stimulation of the GTPase activity of Go1alpha and Gi2alpha.
Thrombin inhibits Bim (Bcl-2-interacting mediator of cell death) expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1.
Thrombin receptor activation by thrombin and receptor-derived peptides in platelet and CHRF-288 cell membranes: receptor-stimulated GTPase and evaluation of agonists and partial agonists.
Thrombin stimulates pertussis toxin-sensitive and -insensitive GTPase activities and ADP-ribosylation of G(i) in human neuroblastoma SH-EP.
Thrombin, unlike vasopressin, appears to stimulate two distinct guanine nucleotide regulatory proteins in human platelets.
Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3.
Thy-1 antibody-triggered neurite outgrowth requires an influx of calcium into neurons via N- and L-type calcium channels.
Toll-like receptor 4 coupled GI protein signaling pathways regulate extracellular signal-regulated kinase phosphorylation and AP-1 activation independent of NFkappaB activation.
Transforming growth factor beta 1 treatment of AKR-2B cells is coupled through a pertussis-toxin-sensitive G-protein(s).
Treatment of rabbit neutrophils with phorbol esters results in increased ADP-ribosylation catalyzed by pertussis toxin and inhibition of the GTPase stimulated by fMet-Leu-Phe.
Two mechanisms of photoendocrine transduction in cultured chick pineal cells: pertussis toxin blocks the acute but not the phase-shifting effects of light on the melatonin rhythm.
Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein.
VIP inhibits N-type Ca2+ channels of sympathetic neurons via a pertussis toxin-insensitive but cholera toxin-sensitive pathway.
[Effect of bacterial toxins on the GTPase activity of transducin from bovine rod outer segments]
[Effects of G-Protein Regulators and Stylar S-RNase on the Growth and Ca(2+) Concentration of Pyrus pyrifolia Pollen Tube.]
[Identification and isolation of GTP-binding regulator protein from plasma membranes of oocytes from the starfish Asterias amurensis]
[Inhibitory effect of pertussis toxin on the metabolism of guanine nucleotides in transducin from bovine outer rod segments]
[The effect of G protein regulator on pollen germination and [Ca2+]i variation in Pyrus serotina Rehd. pollen.]
Wilms Tumor
Carbonic anhydrase IV inhibits colon cancer development by inhibiting the Wnt signalling pathway through targeting the WTAP-WT1-TBL1 axis.
Wiskott-Aldrich Syndrome
An NGF-induced Exo70-TC10 complex locally antagonises Cdc42-mediated activation of N-WASP to modulate neurite outgrowth.
Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein.
Coiling phagocytosis of Borrelia burgdorferi by primary human macrophages is controlled by CDC42Hs and Rac1 and involves recruitment of Wiskott-Aldrich syndrome protein and Arp2/3 complex.
Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP.
Crosstalk between WIP and Rho family GTPases.
Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42.
Disease mechanism: unravelling Wiskott-Aldrich syndrome.
EFC/F-BAR proteins and the N-WASP-WIP complex induce membrane curvature-dependent actin polymerization.
Fluorescence approaches for monitoring interactions of Rho GTPases with nucleotides, regulators, and effectors.
Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway.
Global disruption of the WASP autoinhibited structure on Cdc42 binding. Ligand displacement as a novel method for monitoring amide hydrogen exchange.
Lassa Virus Cell Entry via Dystroglycan Involves an Unusual Pathway of Macropinocytosis.
Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP.
Rho GTPase-formin pairs in cytoskeletal remodelling.
SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site.
The dock-and-coalesce mechanism for the association of a WASP disordered region with the Cdc42 GTPase.
The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis.
The nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott-Aldrich syndrome protein.
Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome.
WIP participates in actin reorganization and ruffle formation induced by PDGF.
Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization.