Information on EC 3.6.4.4 - plus-end-directed kinesin ATPase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.6.4.4
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RECOMMENDED NAME
GeneOntology No.
plus-end-directed kinesin ATPase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O = ADP + phosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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SYSTEMATIC NAME
IUBMB Comments
kinesin ATP phosphohydrolase (plus-end-directed)
Microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (alpha) chains (110 kDa) and two or more light (beta) chains (65-75 kDa). Also hydrolyses GTP.
CAS REGISTRY NUMBER
COMMENTARY hide
9000-83-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Chlamydomonas sp.
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Manually annotated by BRENDA team
African green monkey
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
a bias that favors motion toward the minus-end of microtubules might be used to tune transport in healthy cells when properly regulated but contribute to a disease state when misregulated
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Alexa Fluor 647 ATP + H2O
?
show the reaction diagram
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Alexa Fluor 647 ATP, a fluorescent ATP analog, activity determined by FRET-based assays, Frster resonance energy transfer assays. The fluorescent ATP analog can fuel kinesin-1'S processsive motion and is a suitable substrate analog, but it alters the motor's kinetic parameters
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?
ATP + H2O
ADP + phosphate
show the reaction diagram
GTP + H2O
GDP + phosphate
show the reaction diagram
methylanthraniloyl-ATP + H2O
methylanthraniloyl-ADP + phosphate
show the reaction diagram
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unconventional ATPase cycle, adapted for microtubule depolymerization, low basal activity is accelerated by tubulin and microtubles
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?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + H2O
ADP + phosphate
show the reaction diagram
GTP + H2O
GDP + phosphate
show the reaction diagram
additional information
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methanamine
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(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)(1-methylpiperidin-3-yl)methanone
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(2R)-2-amino-1-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-3-methylbutan-1-one
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(2R)-2-amino-3-((1,1,2-triphenylethyl)sulfanyl)propanoic acid
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(2R)-2-amino-3-((1,1-bis(4-chlorophenyl)-2-phenylethyl)sulfanyl)propanoic acid
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(2R)-2-amino-3-((1,1-bis(4-fluorophenyl)-2-phenylethyl)sulfanyl)propanoic acid
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-
(2R)-2-amino-3-((1,1-bis(4-methylphenyl)-2-phenylethyl)sulfanyl)propanoic acid
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-
(2R)-2-amino-3-((1-(2-fluorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
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(2R)-2-amino-3-((1-(3,4-dichlorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
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-
(2R)-2-amino-3-((1-(3-chlorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
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-
(2R)-2-amino-3-((1-(3-chlorophenyl)-1-(4-chlorophenyl)-2-phenylethyl)sulfanyl)propanoic acid
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(2R)-2-amino-3-((1-(3-hydroxyphenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
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-
(2R)-2-amino-3-((1-(4-chlorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
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-
(2R)-2-amino-3-((1-(4-fluorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
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(2R)-2-amino-3-((1-(4-hydroxyphenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
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-
(2R)-2-amino-3-((1-(4-methylphenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
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-
(2R)-2-amino-3-((2-(3,4-chlorophenyl)-1,1-diphenylethyl)sulfanyl)propanoic acid
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-
(2R)-2-amino-3-((2-(3-chlorophenyl)-1,1-diphenylethyl)sulfanyl)propanoic acid
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-
(2R)-2-amino-3-((2-(4-chlorophenyl)-1,1-diphenylethyl)sulfanyl)propanoic acid
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(2R)-2-amino-3-[(1,1,3-triphenylpropyl)sulfanyl]propanoic acid
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-
(2R,4aS,5R,10bS)-2-((1H-1,2,4-triazol-1-yl)methyl)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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-
(2S)-2-amino-1-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-3-methylbutan-1-one
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-
(4aS,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,10bS)-9-(tert-butyl)-5-(3-chlorophenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,10bS)-9-(tert-butyl)-5-(3-fluorophenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,10bS)-9-(tert-butyl)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-9-carbonitrile
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(4aS,5R,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-9-carboxylic acid
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(4aS,5R,10bS)-5-phenyl-9-(trifluoromethoxy)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-5-phenyl-9-propyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-7,9-dimethyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-7-fluoro-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-8,10-dimethyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-8,9-dimethyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-8-(tert-butyl)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-8-chloro-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-9-(pentafluoro-lambda6-sulfanyl)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-9-(tert-butyl)-5-(1H-imidazol-2-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-9-(tert-butyl)-5-(2-fluorophenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-9-(tert-butyl)-5-(3-chlorophenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-9-(tert-butyl)-5-(3-fluoro-4-methoxyphenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-9-(tert-butyl)-5-(3-fluorophenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-9-(tert-butyl)-5-(4-fluorophenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-9-(tert-butyl)-5-(pyridin-3-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-9-(tert-butyl)-5-(thiazol-2-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-9-(tert-butyl)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-9-chloro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-9-ethyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-9-isopropyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-9-methyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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(4aS,5R,10bS)-N,N-dimethyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-amine
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(4aS,5S,10bS)-9-(tert-butyl)-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
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1-((2R,4aS,5R,10bS)-5-(4-fluorophenyl)-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)-N-methylmethanamine
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1-((2R,4aS,5R,10bS)-9-(tert-butyl)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)-N-methylmethanamine
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1-((2R,4aS,5R,10bS)-9-bromo-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)-N-methylmethanamine
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1-((2R,4aS,5R,10bS)-9-cyclopropyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)-N-methylmethanamine
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1-(1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone
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i.e. tetrahydro-beta-carboline
1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-3-(piperidin-1-yl)propan-1-one
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1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone
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1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
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1-(2-(dimethylamino)ethyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)urea
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1-(3,6-dibromo-9H-carbazol-9-yl)-3-phenethylamino-2-propanol
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1-(3,6-dichloro-9H-carbazol-9-yl)-3-phenethylamino-2-propanol
-
induces cell death
1-(3-hydroxypropyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)urea
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1-(4'-tert-butylbiphenyl-4-yl)urea
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1-(4'-[(trifluoromethyl)sulfonyl]biphenyl-4-yl)urea
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1-(4-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)phenyl)ethanone
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1-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-2-(piperidin-4-yl)ethanone
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1-(benzenesulfinyl)-2,4-dinitrobenzene
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1-(benzenesulfinyl)-2-nitrobenzene
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1-(benzenesulfonyl)-2,4-dinitrobenzene
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1-(benzenesulfonyl)-2-nitro-4-(trifluoromethyl)benzene
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1-(benzenesulfonyl)-2-nitrobenzene
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1-(benzenesulfonyl)-4-chloro-2-nitrobenzene
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i.e. BTB-1, reversibly inhibits the microtubule-stimulated ATPase activity of Kif18A
1-(benzenesulfonyl)-4-fluoro-2-nitrobenzene
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-
1-phenethylamino-3-phenothiazin-10-yl-propan-2-ol
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induces strong mitotic arrest followed by cell death. More than 90% of cells exhibit the monoastral spindle instead of the normal mitotic spindle. Inhibitor selectively kills transformed culture cells; the inhibitor selectively kills transformed cell cultures
1-[(4-chlorophenyl)methanesulfonyl]-2,4-dinitrobenzene
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1-[(4-methoxyphenyl)methanesulfinyl]-2-nitrobenzene
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1-[(4-methoxyphenyl)methanesulfonyl]-2-nitrobenzene
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1-[(4-methylphenyl)methanesulfinyl]-2,4-dinitrobenzene
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1-[(4-methylphenyl)methanesulfonyl]-2,4-dinitrobenzene
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1-[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]urea
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1-[3'-nitro-4'-(trifluoromethyl)biphenyl-4-yl]urea
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1-[3-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]urea
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1-[4'-(propan-2-yl)biphenyl-4-yl]urea
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1-[4'-(trifluoromethyl)biphenyl-4-yl]thiourea
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1-[4'-(trifluoromethyl)biphenyl-4-yl]urea
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1-[4-(1,3-benzodioxol-5-yl)phenyl]urea
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1-[4-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]urea
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-
2-((((2R,4aS,5R,10bS)-9-(tert-butyl)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)(ethyl)amino)ethanol
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2-((((2R,4aS,5R,10bS)-9-chloro-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)amino)ethanol
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2-((1,1,2-triphenylethyl)sulfanyl)ethanaminium tetrafluoroborate
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2-((1,1-bis(4-chlororophenyl)-2-phenylethyl)sulfanyl)ethanamine
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2-((1,1-bis(4-fluorophenyl)-2-phenylethyl)sulfanyl)ethanamine
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2-((1,1-bis(4-methylphenyl)-2-phenylethyl)sulfanyl)ethanamine
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2-((1-(2-fluorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
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2-((1-(3,4-dichlorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
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2-((1-(3-chlorophenyl)-1,2-diphenylethyl)sulfanyl)ethanaminium tetrafluoroborate
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2-((1-(3-chlorophenyl)-1-(4-chlorophenyl)-2-phenylethyl)sulfanyl)ethanamine
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2-((1-(3-hydroxyphenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
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2-((1-(4-chlorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
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2-((1-(4-fluorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
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2-((1-(4-hydroxylphenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
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2-((1-(4-methylphenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
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2-((2R,4aS,5R,10bS)-9-(tert-butyl)-2-((methylamino)methyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)benzenethiol
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2-((4aS,5R,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-yl)acetonitrile
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2-((4aS,5R,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-yl)ethanol
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2-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)-4-chlorobenzenethiol
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2-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)benzenethiol
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2-((diphenyl(pyridin-4-yl)methyl)sulfanyl)ethanamine
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2-(2,4-difluorophenyl)-9-(3,4-dimethylphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
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2-(2-sulfanylethoxy)ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
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2-(4-chloro-2-nitrobenzene-1-sulfinyl)naphthalene
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2-(4-chloro-2-nitrobenzene-1-sulfonyl)thiophene
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2-(dimethylamino)ethyl (((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)carbamate
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2-(methylamino)-N-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)ethanesulfonothioamide
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-
2-(tritylthio)ethanamine
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2-amino-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone
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-
2-[1-(4-methoxyphenyl)-5-oxo-3-[2-(thiophen-2-yl)ethyl]-2-thioxoimidazolidin-4-yl]-N-phenylacetamide
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2-[2-(acetylsulfanyl)ethoxy]ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
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3-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)aniline
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3-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)benzenethiol
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3-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)phenol
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-
3-(2-((2-aminoethyl)sulfonyl)-6-chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenol
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3-(dimethylamino)-N-(((2R,4aS,5R,10bS)-9-isopropyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)propane-1-sulfonamide
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3-amino-1-(1-(2-aminopyridin-4-yl)-6-chloro-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
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3-amino-1-(1-(3-fluorophenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
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3-amino-1-(1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
-
-
3-amino-1-(1-(3-hydroxyphenyl)-6-(trifluoromethoxy)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
-
-
3-amino-1-(1-(3-hydroxyphenyl)-6-isopropyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
-
-
3-amino-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
-
-
3-amino-1-(1-(3-hydroxyphenyl)-6-phenyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
-
-
3-amino-1-(1-(3-methoxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
-
-
3-amino-1-(6-bromo-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
-
-
3-amino-1-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
-
-
3-amino-1-(6-chloro-1-cyclohexyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
-
-
3-amino-1-(6-ethyl-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
-
-
3-amino-1-(6-fluoro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
-
-
3-amino-1-(6-hydroxy-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
-
-
3-amino-1-(6-methyl-1-phenyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
-
-
3-amino-N-methyl-N-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)propane-1-sulfonothioamide
-
-
4'-(trifluoromethyl)biphenyl-4-yl sulfamate
-
-
4-((((2R)-2-ammonio-2-carboxyethyl)sulfanyl)(diphenyl)-methyl)pyridinium tetrafluoroborate
-
-
4-((2R,4aS,5R,10bS)-2-((methylamino)methyl)-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)phenol
-
-
4-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)-2-fluorophenol
-
-
4-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)benzene-1,2-diol
-
-
4-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)phenol
-
-
4-((4aS,5S,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)butan-1-ol
-
-
4-(2-[1-(2,4,6-trifluorophenyl)cyclopropyl]-1,3-thiazol-4-yl)pyridine
-
-
4-(2-[1-(2,4-difluorophenyl)cyclopropyl]-1,3-thiazol-4-yl)pyridine
-
-
4-(2-[1-(2,6-difluorophenyl)cyclopropyl]-1,3-thiazol-4-yl)pyridine
-
-
4-(2-[1-(2-fluorophenyl)cyclopropyl]-1,3-thiazol-4-yl)pyridine
-
-
4-(2-[1-(4-chlorophenyl)cyclopropyl]-1,3-thiazol-4-yl)pyridine
-
-
4-(2-[1-(4-fluorophenyl)cyclopropyl]-1,3-thiazol-4-yl)pyridine
-
treatmebnt of cells results in inhibition of proliferation and induction of caspase 3 activity with EC50 values of 0.0017 and 0.0011 mM, respectively. Compound induces monoastral spindles in A2780 cells when incubated at concentrations above that required to induce a full mitotic arrest
4-(benzenesulfonyl)-1-chloro-2-nitrobenzene
-
-
4-amino-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)butan-1-one
-
-
4-chloro-1-(4-methoxybenzene-1-sulfinyl)-2-nitrobenzene
-
-
4-chloro-1-[(4-chlorophenyl)methanesulfonyl]-2-nitrobenzene
-
-
4-chloro-1-[(4-methoxyphenyl)methanesulfonyl]-2-nitrobenzene
-
-
4-chloro-1-[(4-methylphenyl)methanesulfonyl]-2-nitrobenzene
-
-
4-chloro-2-nitro-1-phenoxybenzene
-
-
4-[2-(1-phenylcyclopropyl)-1,3-thiazol-4-yl]pyridine 1-oxide
-
-
4-[[3-(methoxycarbonyl)-2-methyl-5a,9a-dihydronaphtho[1,2-b]furan-5-yl]sulfamoyl]benzoic acid
-
-
5-(2-(3-aminopropanoyl)-6-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)benzo[d]oxazol-2(3H)-one
-
-
5-(2-fluorophenyl)-2,9-dimethyl-5,6-dihydropyrazolo[1,5-c]quinazoline
-
-
5-[2-(1-phenylcyclopropyl)-1,3-thiazol-4-yl]pyridine-2-carbonitrile
-
-
6-(4-chloro-2-nitrobenzene-1-sulfonyl)-1,4-dihydronaphthalene
-
-
6-[4-(trifluoromethyl)phenyl]-3,4-dihydroquinolin-2(1H)-one
-
-
actin
AK065586
inhibition in the presence of microtubles
adenosine 5'-[beta,gamma-imido]triphosphate
-
nonhydrolyzable analogue of ATP, blocks enzyme by rapid replacement of ATP
adenylylimidodiphosphate
-
AMP-PNP
AMP-PNP
-
binding structure
Calmodulin
-
activated calmodulin inhibits KCBP interaction with microtubules thereby abolishing its motor- and microtubules-dependent ATPase activity
docetaxel
-
-
ethyl 3-acetyl-4-[3-(acetyloxy)phenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
-
no inhibition in vitro, inhibitory in cell-based assay
ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
-
i.e. monastrol
ethyl 4-[3-(acetyloxy)phenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
-
no inhibition in vitro, inhibitory in cell-based assay
furan-2-yl[4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl]methanone
-
-
ispinesib
-
SB-715992, a potent and selective inhibitor of kinesin spindle protein
kinesin spindle protein activator-1
-
inhibits kinesin spindle protein ATP turnover in the presence of microtubules
-
monastrol
N-(((2R,4aS,5R,10bS)-9-bromo-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)-4-(dimethylamino)butanamide
-
-
N-(((2R,4aS,5R,10bS)-9-chloro-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)-2-(dimethylamino)ethanesulfonamide
-
-
N-(2-((((2R,4aS,5R,10bS)-9-bromo-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)amino)ethyl)acetamide
-
-
N-(2-aminoethyl)-4-methyl-N-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)benzamide
-
-
N-(3-(2-(3-aminopropanoyl)-6-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)methanesulfonamide
-
-
N-(3-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-3-oxopropyl)methanesulfonamide
-
-
N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl]-3-fluoro-4-methylbenzamide
-
-
N-(4-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)phenyl)acetamide
-
-
N-(4-fluorophenyl)-2-[1-(4-fluorophenyl)-3-[2-(3-methylthiophen-2-yl)ethyl]-5-oxo-2-thioxoimidazolidin-4-yl]acetamide
-
-
N-(4-methoxyphenyl)-2-[3-[2-(3-methylthiophen-2-yl)ethyl]-5-oxo-1-phenyl-2-thioxoimidazolidin-4-yl]acetamide
-
-
N-ethylmaleimide
-
-
N-[3-amino-4'-(trifluoromethyl)biphenyl-4-yl]sulfuric diamide
-
-
N-[3-chloro-4'-(trifluoromethyl)biphenyl-4-yl]sulfuric diamide
-
-
N-[3-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]sulfuric diamide
-
-
N-[3-methoxy-4'-(trifluoromethyl)biphenyl-4-yl]sulfuric diamide
-
-
N-[4'-(trifluoromethyl)biphenyl-4-yl]methanesulfonamide
-
-
N-[4'-(trifluoromethyl)biphenyl-4-yl]sulfuric diamide
-
-
N1-phenyl-N1-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)ethane-1,2-diamine
-
-
PVZB1194
allosteric inhibitor, biphenyl-type inhibitor, binding structure of the inhibitor in complex with the Eg5 motor domain: inhibitor PVZB1194 binds to the alpha4/alpha6 allosteric pocket 15 A from the ATP-binding pocket, which differs from conventional allosteric inhibitors that bind to the allosteric L5/alpha2/alpha 3 pocket of Eg5. Binding of the inhibitor is involved in the neck-linker conformation and also causes conformational changes around the ATP-binding pocket through Tyr104 to affect the interaction of ATP with the pocket. Folding rearrangement of enzyme Eg5 induced by PVZB1194 in the absence of nucleotides and microtubules. Residue Tyr104 is involved in ATP-competitive inhibition by PVZB1194
S-trityl-L-cysteine
SB-731489
-
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
kinesin spindle protein activator-1
-
accelerates the basal ATP turnover rate circa 10fold in the absence of microtubules
-
microtubule
-
microtubules
-
strong increase in ATPase activity in the presence of microtubules
-
microtubuli
-
ATPase activity of Kip3p is activated by both microtubules and unpolymerized tubulin
-
potassium acetate
-
full-length protein and truncated protein Kif3-592, optimum concentration 200 mM leading to maximum speed of 2 micrometer per s
tubulin heterodimer
-
tubulin-vinblastine assemblies
stimulation of the ATPase activity of the enzyme
-
unpolymerized tubulin
-
ATPase activity of Kip3p is activated by both microtubules and unpolymerized tubulin
-
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.032
Alexa Fluor 647 ATP
-
+/-0.022 mM, Vmax: 247 nmol/s, pH and temperature not specified in the publication. The fluorescent ATP analog can fuel kinesin-1'S processsive motion and is a suitable substrate analog, but it alters the motor's kinetic parameters
0.000047 - 103
ATP
0.0004
methylanthraniloyl-ATP
-
pH 6.9, 25C
additional information
additional information
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
34
ADP
Neurospora crassa
-
in presence of microtubule the ATP hydrolysis is activated 3fold to 4fold compared to kcat, 125 vs. 34 s-1, while phosphate release is approximately equally fast: 29 s-1, pH and temperature not specified in the publication
0.00095 - 144
ATP
0.0009
methylanthraniloyl-ATP
Homo sapiens
-
basal activity, in absence of tubulin or microtubles, pH 6.9, 25C
29
phosphate
Neurospora crassa
-
in presence of microtubule the ATP hydrolysis is activated 3fold to 4fold compared to kcat, 125 vs. 34 s-1, while phosphate release is approximately equally fast: 29 s-1, pH and temperature not specified in the publication
additional information
additional information
Neurospora crassa
-
in presence of microtubule the ATP hydrolysis is activated 3fold to 4fold compared to kcat, 125 vs. 34 s-1, while phosphate release is approximately equally fast: 29 s-1; steady state ATPase parameters, kcat values and gliding velocities of truncated NcKin3 constructs
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000017 - 0.000109
6-[4-(trifluoromethyl)phenyl]-3,4-dihydroquinolin-2(1H)-one
0.00045 - 0.054
ADP
0.000001 - 0.00035
N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl]-3-fluoro-4-methylbenzamide
0.0000035 - 0.000006
N-[3-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]sulfuric diamide
0.00011 - 0.00012
N-[4'-(trifluoromethyl)biphenyl-4-yl]methanesulfonamide
0.0000062 - 0.000007
N-[4'-(trifluoromethyl)biphenyl-4-yl]sulfuric diamide
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00002
((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methanamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0009
(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)(1-methylpiperidin-3-yl)methanone
Homo sapiens
-
pH and temperature not specified in the publication
0.0081
(2R)-2-amino-1-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-3-methylbutan-1-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000138
(2R)-2-amino-3-((1,1,2-triphenylethyl)sulfanyl)propanoic acid
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0002518
(2R)-2-amino-3-((1,1-bis(4-chlorophenyl)-2-phenylethyl)sulfanyl)propanoic acid
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0001782
(2R)-2-amino-3-((1,1-bis(4-fluorophenyl)-2-phenylethyl)sulfanyl)propanoic acid
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0001065
(2R)-2-amino-3-((1,1-bis(4-methylphenyl)-2-phenylethyl)sulfanyl)propanoic acid
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0002168
(2R)-2-amino-3-((1-(2-fluorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0001912
(2R)-2-amino-3-((1-(3,4-dichlorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0001289
(2R)-2-amino-3-((1-(3-chlorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0005675
(2R)-2-amino-3-((1-(3-chlorophenyl)-1-(4-chlorophenyl)-2-phenylethyl)sulfanyl)propanoic acid
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0000676
(2R)-2-amino-3-((1-(3-hydroxyphenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0000586
(2R)-2-amino-3-((1-(4-chlorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0001505
(2R)-2-amino-3-((1-(4-fluorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0001594
(2R)-2-amino-3-((1-(4-hydroxyphenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0001676
(2R)-2-amino-3-((1-(4-methylphenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.005278
(2R)-2-amino-3-((2-(3,4-chlorophenyl)-1,1-diphenylethyl)sulfanyl)propanoic acid
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0002375
(2R)-2-amino-3-((2-(3-chlorophenyl)-1,1-diphenylethyl)sulfanyl)propanoic acid
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0004558
(2R)-2-amino-3-((2-(4-chlorophenyl)-1,1-diphenylethyl)sulfanyl)propanoic acid
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.01584
(2R)-2-amino-3-[(1,1,3-triphenylpropyl)sulfanyl]propanoic acid
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.000006
(2R,4aS,5R,10bS)-2-((1H-1,2,4-triazol-1-yl)methyl)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.00076
(2S)-2-amino-1-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-3-methylbutan-1-one
Homo sapiens
-
pH and temperature not specified in the publication
0.01
(4aS,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
above 0.01 mM, pH and temperature not specified in the publication
0.01
(4aS,10bS)-9-(tert-butyl)-5-(3-chlorophenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
above 0.01 mM, pH and temperature not specified in the publication
0.00087
(4aS,10bS)-9-(tert-butyl)-5-(3-fluorophenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.0003
(4aS,10bS)-9-(tert-butyl)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.01
(4aS,5R,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
above 0.01 mM, pH and temperature not specified in the publication
0.01
(4aS,5R,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-9-carbonitrile
Homo sapiens
-
above 0.01 mM, pH and temperature not specified in the publication
0.01
(4aS,5R,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline-9-carboxylic acid
Homo sapiens
-
above 0.01 mM, pH and temperature not specified in the publication
0.0037
(4aS,5R,10bS)-5-phenyl-9-(trifluoromethoxy)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.00011
(4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.00036
(4aS,5R,10bS)-5-phenyl-9-propyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.01
(4aS,5R,10bS)-7,9-dimethyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
above 0.01 mM, pH and temperature not specified in the publication
0.00009
(4aS,5R,10bS)-7-fluoro-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.01
(4aS,5R,10bS)-8,10-dimethyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
above 0.01 mM, pH and temperature not specified in the publication
0.00125
(4aS,5R,10bS)-8,9-dimethyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.01
(4aS,5R,10bS)-8-(tert-butyl)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
above 0.01 mM, pH and temperature not specified in the publication
0.00054
(4aS,5R,10bS)-8-chloro-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.00091
(4aS,5R,10bS)-9-(pentafluoro-lambda6-sulfanyl)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.01
(4aS,5R,10bS)-9-(tert-butyl)-5-(1H-imidazol-2-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
above 0.01 mM, pH and temperature not specified in the publication
0.00017
(4aS,5R,10bS)-9-(tert-butyl)-5-(2-fluorophenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0068
(4aS,5R,10bS)-9-(tert-butyl)-5-(3-chlorophenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.01
(4aS,5R,10bS)-9-(tert-butyl)-5-(3-fluoro-4-methoxyphenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
above 0.01 mM, pH and temperature not specified in the publication
0.00035
(4aS,5R,10bS)-9-(tert-butyl)-5-(3-fluorophenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.00027
(4aS,5R,10bS)-9-(tert-butyl)-5-(4-fluorophenyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.0011
(4aS,5R,10bS)-9-(tert-butyl)-5-(pyridin-3-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.00053
(4aS,5R,10bS)-9-(tert-butyl)-5-(thiazol-2-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.00012
(4aS,5R,10bS)-9-(tert-butyl)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.00072
(4aS,5R,10bS)-9-chloro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.00013
(4aS,5R,10bS)-9-ethyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.00013
(4aS,5R,10bS)-9-isopropyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.00042
(4aS,5R,10bS)-9-methyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
pH and temperature not specified in the publication
0.0053
(4aS,5R,10bS)-N,N-dimethyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.01
(4aS,5S,10bS)-9-(tert-butyl)-5-cyclohexyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
Homo sapiens
-
above 0.01 mM, pH and temperature not specified in the publication
0.000058
1-((2R,4aS,5R,10bS)-5-(4-fluorophenyl)-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)-N-methylmethanamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000004
1-((2R,4aS,5R,10bS)-9-(tert-butyl)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)-N-methylmethanamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000003
1-((2R,4aS,5R,10bS)-9-bromo-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)-N-methylmethanamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000011
1-((2R,4aS,5R,10bS)-9-cyclopropyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)-N-methylmethanamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0025
1-(1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone
Homo sapiens
-
i.e. tetrahydro-beta-carboline, pH and temperature not specified in the publication
0.0001
1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-3-(piperidin-1-yl)propan-1-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0002
1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone
Homo sapiens
-
pH and temperature not specified in the publication
0.00046
1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000008
1-(2-(dimethylamino)ethyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)urea
Homo sapiens
-
i.e. EMD 534085, pH and temperature not specified in the publication
0.00001
1-(3-hydroxypropyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)urea
Homo sapiens
-
pH and temperature not specified in the publication
0.000054
1-(4'-tert-butylbiphenyl-4-yl)urea
Homo sapiens
-
-
0.000058
1-(4'-[(trifluoromethyl)sulfonyl]biphenyl-4-yl)urea
Homo sapiens
-
-
0.01
1-(4-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)phenyl)ethanone
Homo sapiens
-
above 0.01 mM, pH and temperature not specified in the publication
0.00086
1-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-2-(piperidin-4-yl)ethanone
Homo sapiens
-
pH and temperature not specified in the publication
0.0102
1-(benzenesulfonyl)-2,4-dinitrobenzene
Homo sapiens
-
pH and temperature not specified in the publication
0.0103
1-(benzenesulfonyl)-2-nitro-4-(trifluoromethyl)benzene
Homo sapiens
-
pH and temperature not specified in the publication
0.003
1-(benzenesulfonyl)-2-nitrobenzene
Homo sapiens
-
pH and temperature not specified in the publication
0.0017
1-(benzenesulfonyl)-4-chloro-2-nitrobenzene
Homo sapiens
-
pH and temperature not specified in the publication
0.0048
1-(benzenesulfonyl)-4-fluoro-2-nitrobenzene
Homo sapiens
-
pH and temperature not specified in the publication
0.00152
1-phenethylamino-3-phenothiazin-10-yl-propan-2-ol
Homo sapiens
-
pH 6.8, 30C
0.000015
1-[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]urea
Homo sapiens
-
-
0.000028
1-[3'-nitro-4'-(trifluoromethyl)biphenyl-4-yl]urea
Homo sapiens
-
-
0.000015
1-[3-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]urea
Homo sapiens
-
-
0.000057
1-[4'-(propan-2-yl)biphenyl-4-yl]urea
Homo sapiens
-
-
0.000011
1-[4'-(trifluoromethyl)biphenyl-4-yl]thiourea
Homo sapiens
-
-
0.000039
1-[4'-(trifluoromethyl)biphenyl-4-yl]urea
Homo sapiens
-
-
0.000031
1-[4-(1,3-benzodioxol-5-yl)phenyl]urea
Homo sapiens
-
-
0.000067
1-[4-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]urea
Homo sapiens
-
-
0.000019
2-((((2R,4aS,5R,10bS)-9-(tert-butyl)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)(ethyl)amino)ethanol
Homo sapiens
-
pH and temperature not specified in the publication
0.000007
2-((((2R,4aS,5R,10bS)-9-chloro-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)amino)ethanol
Homo sapiens
-
pH and temperature not specified in the publication
0.0006845
2-((1,1,2-triphenylethyl)sulfanyl)ethanaminium tetrafluoroborate
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0004037
2-((1,1-bis(4-chlororophenyl)-2-phenylethyl)sulfanyl)ethanamine
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0005878
2-((1,1-bis(4-fluorophenyl)-2-phenylethyl)sulfanyl)ethanamine
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.000261
2-((1,1-bis(4-methylphenyl)-2-phenylethyl)sulfanyl)ethanamine
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0007895
2-((1-(2-fluorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0002293
2-((1-(3,4-dichlorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.000519
2-((1-(3-chlorophenyl)-1,2-diphenylethyl)sulfanyl)ethanaminium tetrafluoroborate
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0004367
2-((1-(3-chlorophenyl)-1-(4-chlorophenyl)-2-phenylethyl)sulfanyl)ethanamine
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0002561
2-((1-(3-hydroxyphenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0001409
2-((1-(4-chlorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0005779
2-((1-(4-fluorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0006656
2-((1-(4-hydroxylphenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0001719
2-((1-(4-methylphenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.000005
2-((2R,4aS,5R,10bS)-9-(tert-butyl)-2-((methylamino)methyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)benzenethiol
Homo sapiens
-
pH and temperature not specified in the publication
0.0005
2-((4aS,5R,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-yl)acetonitrile
Homo sapiens
-
pH and temperature not specified in the publication
0.01
2-((4aS,5R,10bS)-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-9-yl)ethanol
Homo sapiens
-
pH and temperature not specified in the publication
0.0003
2-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)-4-chlorobenzenethiol
Homo sapiens
-
pH and temperature not specified in the publication
0.000025
2-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)benzenethiol
Homo sapiens
-
pH and temperature not specified in the publication
0.0009422
2-((diphenyl(pyridin-4-yl)methyl)sulfanyl)ethanamine
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.0415
2-(2,4-difluorophenyl)-9-(3,4-dimethylphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide
Homo sapiens
-
inhibition of basal ATPase activity, pH 6.9, 25C
0.004 - 0.0055
2-(2-sulfanylethoxy)ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
0.0064
2-(4-chloro-2-nitrobenzene-1-sulfonyl)thiophene
Homo sapiens
-
pH and temperature not specified in the publication
0.000014
2-(dimethylamino)ethyl (((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.000004
2-(methylamino)-N-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)ethanesulfonothioamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0002412
2-(tritylthio)ethanamine
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.000049
2-amino-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone
Homo sapiens
-
pH and temperature not specified in the publication
0.001
2-[1-(4-methoxyphenyl)-5-oxo-3-[2-(thiophen-2-yl)ethyl]-2-thioxoimidazolidin-4-yl]-N-phenylacetamide
Homo sapiens
-
inhibition of basal ATPase activity, pH 6.9, 25C
0.0045 - 0.0115
2-[2-(acetylsulfanyl)ethoxy]ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
0.0023
3-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)aniline
Homo sapiens
-
pH and temperature not specified in the publication
0.00012
3-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)benzenethiol
Homo sapiens
-
pH and temperature not specified in the publication
0.00004
3-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)phenol
Homo sapiens
-
pH and temperature not specified in the publication
0.000186
3-(2-((2-aminoethyl)sulfonyl)-6-chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenol
Homo sapiens
-
pH and temperature not specified in the publication
0.000002
3-(dimethylamino)-N-(((2R,4aS,5R,10bS)-9-isopropyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)propane-1-sulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0066
3-amino-1-(1-(2-aminopyridin-4-yl)-6-chloro-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0001
3-amino-1-(1-(3-fluorophenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00063
3-amino-1-(1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0002
3-amino-1-(1-(3-hydroxyphenyl)-6-(trifluoromethoxy)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
Homo sapiens
-
pH and temperature not specified in the publication
0.025
3-amino-1-(1-(3-hydroxyphenyl)-6-isopropyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
Homo sapiens
-
above 0.025 mM, pH and temperature not specified in the publication
0.00002 - 0.000058
3-amino-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
0.0017
3-amino-1-(1-(3-hydroxyphenyl)-6-phenyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
Homo sapiens
-
pH and temperature not specified in the publication
0.011
3-amino-1-(1-(3-methoxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000027
3-amino-1-(6-bromo-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000039
3-amino-1-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00023
3-amino-1-(6-chloro-1-cyclohexyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000011
3-amino-1-(6-ethyl-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00076
3-amino-1-(6-fluoro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0045
3-amino-1-(6-hydroxy-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000175
3-amino-1-(6-methyl-1-phenyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000007
3-amino-N-methyl-N-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)propane-1-sulfonothioamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000064
4'-(trifluoromethyl)biphenyl-4-yl sulfamate
Homo sapiens
-
-
0.0005142
4-((((2R)-2-ammonio-2-carboxyethyl)sulfanyl)(diphenyl)-methyl)pyridinium tetrafluoroborate
Homo sapiens
-
inhibition of basal ATPase activity, pH not specified in the publication, 25C
0.000004
4-((2R,4aS,5R,10bS)-2-((methylamino)methyl)-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)phenol
Homo sapiens
-
pH and temperature not specified in the publication
0.000017
4-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)-2-fluorophenol
Homo sapiens
-
pH and temperature not specified in the publication
0.000095
4-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)benzene-1,2-diol
Homo sapiens
-
pH and temperature not specified in the publication
0.000034
4-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)phenol
Homo sapiens
-
pH and temperature not specified in the publication
0.01
4-((4aS,5S,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)butan-1-ol
Homo sapiens
-
above 0.01 mM, pH and temperature not specified in the publication
0.00023
4-(2-[1-(2,4,6-trifluorophenyl)cyclopropyl]-1,3-thiazol-4-yl)pyridine
Homo sapiens
-
-
0.00033
4-(2-[1-(2,4-difluorophenyl)cyclopropyl]-1,3-thiazol-4-yl)pyridine
Homo sapiens
-
-
0.00028
4-(2-[1-(2,6-difluorophenyl)cyclopropyl]-1,3-thiazol-4-yl)pyridine
Homo sapiens
-
-
0.0003
4-(2-[1-(2-fluorophenyl)cyclopropyl]-1,3-thiazol-4-yl)pyridine
Homo sapiens
-
-
0.00029
4-(2-[1-(4-chlorophenyl)cyclopropyl]-1,3-thiazol-4-yl)pyridine
Homo sapiens
-
-
0.00054
4-(2-[1-(4-fluorophenyl)cyclopropyl]-1,3-thiazol-4-yl)pyridine
Homo sapiens
-
pH 6.8, 22C
0.000086
4-amino-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)butan-1-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00047
4-[2-(1-phenylcyclopropyl)-1,3-thiazol-4-yl]pyridine 1-oxide
Homo sapiens
-
-
0.0791
4-[[3-(methoxycarbonyl)-2-methyl-5a,9a-dihydronaphtho[1,2-b]furan-5-yl]sulfamoyl]benzoic acid
Homo sapiens
-
inhibition of basal ATPase activity, pH 6.9, 25C
0.025
5-(2-(3-aminopropanoyl)-6-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)benzo[d]oxazol-2(3H)-one
Homo sapiens
-
above 0.025 mM, pH and temperature not specified in the publication
0.0063
5-(2-fluorophenyl)-2,9-dimethyl-5,6-dihydropyrazolo[1,5-c]quinazoline
Homo sapiens
-
inhibition of basal ATPase activity, pH 6.9, 25C
0.000532
5-[2-(1-phenylcyclopropyl)-1,3-thiazol-4-yl]pyridine-2-carbonitrile
Homo sapiens
-
-
0.00000045 - 0.000036
6-[4-(trifluoromethyl)phenyl]-3,4-dihydroquinolin-2(1H)-one
0.00000023 - 0.0000003
docetaxel
0.0625
ethyl 3-acetyl-4-[3-(acetyloxy)phenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Homo sapiens
-
cell-based assay on monoastral spindles
0.0061 - 0.0513
ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
0.05
ethyl 4-[3-(acetyloxy)phenyl]-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Homo sapiens
-
cell-based assay on monoastral spindles
0.0015 - 0.0092
furan-2-yl[4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl]methanone
0.0023
kinesin spindle protein activator-1
Homo sapiens
-
-
-
0.000005
N-(((2R,4aS,5R,10bS)-9-bromo-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)-4-(dimethylamino)butanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000002
N-(((2R,4aS,5R,10bS)-9-chloro-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)-2-(dimethylamino)ethanesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000006
N-(2-((((2R,4aS,5R,10bS)-9-bromo-7-fluoro-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)amino)ethyl)acetamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000065
N-(2-aminoethyl)-4-methyl-N-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.025
N-(3-(2-(3-aminopropanoyl)-6-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)methanesulfonamide
Homo sapiens
-
above 0.025 mM, pH and temperature not specified in the publication
0.000155
N-(3-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-3-oxopropyl)methanesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
0.01
N-(4-((4aS,5R,10bS)-9-(tert-butyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)phenyl)acetamide
Homo sapiens
-
above 0.01 mM, pH and temperature not specified in the publication
0.0006
N-(4-fluorophenyl)-2-[1-(4-fluorophenyl)-3-[2-(3-methylthiophen-2-yl)ethyl]-5-oxo-2-thioxoimidazolidin-4-yl]acetamide
Homo sapiens
-
inhibition of basal ATPase activity, pH 6.9, 25C
0.0024
N-(4-methoxyphenyl)-2-[3-[2-(3-methylthiophen-2-yl)ethyl]-5-oxo-1-phenyl-2-thioxoimidazolidin-4-yl]acetamide
Homo sapiens
-
inhibition of basal ATPase activity, pH 6.9, 25C
0.000024
N-[3-amino-4'-(trifluoromethyl)biphenyl-4-yl]sulfuric diamide
Homo sapiens
-
-
0.000067
N-[3-chloro-4'-(trifluoromethyl)biphenyl-4-yl]sulfuric diamide
Homo sapiens
-
-
0.000005
N-[3-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]sulfuric diamide
Homo sapiens
-
-
0.000066
N-[3-methoxy-4'-(trifluoromethyl)biphenyl-4-yl]sulfuric diamide
Homo sapiens
-
-
0.000018
N-[4'-(trifluoromethyl)biphenyl-4-yl]sulfuric diamide
Homo sapiens
-
-
0.000019
N1-phenyl-N1-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)ethane-1,2-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0001859 - 0.0005
S-trityl-L-cysteine
0.00000046 - 0.000903
SB-731489
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.5
AK065586
in the presence of microtubles
6.8
assay at
7.5
-
assay at
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.5 - 9
AK065586
in the presence of microtubles
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20
-
assay at
22
-
assay at room temperature
25
assay at
additional information
-
monomeric and dimeric activation energies (Arrhenius equation) 5.2 kJ/mol and 4.1 kJ/mol, respectively
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.6
-
theoretical isoelectric point of Klp5p
10.6
-
theoretical isoelectric point of Klp6p
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
apex
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
; pancreatic beta-cell
Manually annotated by BRENDA team
-
epididymal
Manually annotated by BRENDA team
-
african green monkey kidney cell line
Manually annotated by BRENDA team
additional information
-
BC12 is mainly expressed in tissues undergoing cell division and secondary wall thickening
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
kinesin KIF16B transports early endosomes to the plus end of microtubules
Manually annotated by BRENDA team
Chlamydomonas sp.
-
the FLA3 KAP subunit is required for localization of kinesin-2 to the site of flagellar assembly and processive anterograde intraflagellar transport
-
Manually annotated by BRENDA team
-
associated
Manually annotated by BRENDA team
-
cytoplasmic kinesin localizes to phagosomes in vivo
-
Manually annotated by BRENDA team
-
KIF1C is enriched at a subset of microtubule plus ends, that contact podosomes
Manually annotated by BRENDA team
additional information
-
KIFC1 is associated with membranous organelles, not associated with the mitotic spindle
-
Manually annotated by BRENDA team