Reference on EC 3.5.4.9 - methenyltetrahydrofolate cyclohydrolase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Paukert, J.L.; Rabinowitz, J.C.
Formyl-methenyl-methylenetetrahydrofolate synthetase (combined): a multifunctional protein in eukaryotic folate metabolism
Methods Enzymol.
66
616-626
1980
Saccharomyces cerevisiae, Ovis aries, Sus scrofa
Cossins, E.A.; Kirk, C.D.; Imeson, H.C.; Zheng, L.l.
Enzymes for synthesis of 10-formyltetrahydrofolate in plants. Characterization of a monofunctional 10-formyltetrahydrofolate synthetase and copurification of 5,10-methylenetetrahydrofolate dehydrogenase and 5,10-methenyltetrahydrofolate cyclohydrolase activities
Adv. Exp. Med. Biol.
338
707-710
1993
Pisum sativum
Kerby, R.; Zeikus, J.G.
Catabolic enzymes of the acetogen Butyribacterium methylotrophicum grown on single-carbon substrates
J. Bacteriol.
169
5605-5609
1987
[Butyribacterium] methylotrophicum
Ljungdahl, L.G.; Clark, J.E.
Purification of 5,10-methenyltetrahydrofolate cyclohydrolase from Clostridium formicoaceticum
Methods Enzymol.
122
385-391
1986
Acetobacterium woodii, Saccharomyces cerevisiae, Clostridium formicaceticum, Moorella thermoacetica, Moorella thermoautotrophica, Escherichia coli
Clark, J.E.; Ragsdale, S.W.; Ljungdahl, L.G.; Wiegel, J.
Levels of enzymes involved in the synthesis of acetate from CO2 in Clostridium thermoautotrophicum
J. Bacteriol.
151
507-509
1982
Acetobacterium woodii, Clostridium aceticum, Clostridium formicaceticum, Moorella thermoacetica, Moorella thermoautotrophica
Clark, J.E.; Ljungdahl, L.G.
Purification and properties of 5,10-methenyltetrahydrofolate cyclohydrolase from Clostridium formicoaceticum
J. Biol. Chem.
257
3833-3836
1982
Acetobacterium woodii, Clostridium formicaceticum, Escherichia coli, Gallus gallus, Gottschalkia acidurici, Moorella thermoacetica, Ovis aries, Saccharomyces cerevisiae, Sus scrofa
Jaffe, J.J.; Chrin, L.R.; Smith, R.B.
5,10-Methenyltetrahydrofolate cyclohydrolase and 5-formyltetrahydrofolate cyclodehydrase in Aedes aegypti
Comp. Biochem. Physiol. B
66
597-600
1980
Aedes aegypti, Bos taurus, Oryctolagus cuniculus, Ovis aries, Sus scrofa, Aedes aegypti black-eye
-
Tan, L.U.L.; MacKenzie, R.E.
Methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase from porcine liver. Location of the activities in two domains of the multifunctional polypeptide
Can. J. Biochem.
57
806-812
1979
Oryctolagus cuniculus, Sus scrofa
Cohen, L.; MacKenzie, R.E.
Methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase from porcine liver. Interaction between the dehydrogenase and cyclohydrolase activities of the multifunctional enzyme
Biochim. Biophys. Acta
522
311-317
1978
Saccharomyces cerevisiae, Ovis aries, Sus scrofa
Tan, L.U.L.; Drury, E.J.; MacKenzie, R.E.
Methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase. A multifunctional protein from porcine liver
J. Biol. Chem.
252
1117-1122
1977
Bos taurus, Clostridium cylindrosporum, Sus scrofa
Suzuki, N.; Iwai, K.
The occurrence and properties of methenyltetrahydrofolate cyclohydrolase in plants
Plant Cell Physiol.
14
319-327
1973
Allium sp., Asparagus officinalis, Bos taurus, Brassica sp., Flammulina velutipes, Oryctolagus cuniculus, Lactuca sativa, Lentinula edodes, Petroselinum sp., Vigna mungo, Pisum sativum, Spinacia oleracea, Trifolium sp.
-
Tabor, H.; Wyngarden, L.
The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid
J. Biol. Chem.
234
1830-1846
1959
Bos taurus, Cavia porcellus, Gottschalkia acidurici, Clostridium cylindrosporum, Oryctolagus cuniculus, Felis sp., Ovis aries, Homo sapiens, Mus musculus, Pseudomonas fluorescens, Rattus norvegicus, Sus scrofa
Schnell, E.; Rochow, E.G.
The enzymatic synthesis of N10-formyltetrahydrofolic acid and its role in ATP formation during formiminoglycine degradation
J. Am. Chem. Soc.
78
4176-4178
1956
Gottschalkia acidurici, Clostridium cylindrosporum
-
D'Ari, L.; Rabinowitz, J.C.
Purification, characterization, cloning, and amino acid sequence of the bifunctional enzyme 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase from Escherichia coli
J. Biol. Chem.
266
23953-23958
1991
Saccharomyces cerevisiae, Gallus gallus, Clostridium cylindrosporum, Moorella thermoacetica, Columba sp., Oryctolagus cuniculus, Escherichia coli, Ovis aries, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa, Escherichia coli BE
Tremblay, G.B.; Mejia, N.R.; MacKenzie, R.E.
The NADP-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase is not expressed in Spodoptera frugiperda cells
J. Biol. Chem.
267
8281-8285
1992
Saccharomyces cerevisiae, Rattus norvegicus, Spodoptera frugiperda, Spodoptera frugiperda Sf9
Xiao-Ming, Y.; MacKenzie, R.E.
Expression of human NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase in Escherichia coli: Purification and partial characterization
Protein Expr. Purif.
3
256-262
1992
Homo sapiens
Pelletier, J.N.; MacKenzie, R.E.
Binding to the 2',5'-ADP subsite stimulates cyclohydrolase activity of human NADP+-dependent methylenetetrahydrofolate dehydrogenase/cyclohydrolase
Biochemistry
33
1900-1906
1994
Saccharomyces cerevisiae, Homo sapiens, Sus scrofa
Kirk, C.D.; Chen, L.; Imeson, H.C.; Cossins, E.A.
A 5,10-methylenetetrahydrofolate dehydrogenase: 5,10-methenyltetrahydrofolate cyclohydrolase protein from Pisum sativum
Phytochemistry
39
1309-1317
1995
Vicia faba, Gottschalkia acidurici, Moorella thermoacetica, Escherichia coli, Hordeum vulgare, Neurospora sp., Pisum sativum, Spinacia oleracea, Triticum aestivum, Zea mays, Escherichia coli BE
-
Pawelek, P.D.; MacKenzie, R.E.
Methylenetetrahydrofolate dehydrogenase-cyclohydrolase from Photobacterium phosphoreum shares properties with a mammalian mitochondrial homologue
Biochim. Biophys. Acta
1296
47-54
1996
Acetobacterium woodii, Saccharomyces cerevisiae, Clostridium formicaceticum, Drosophila melanogaster, Escherichia coli, Homo sapiens, Mus musculus, Photobacterium phosphoreum, Rattus norvegicus, Salmonella enterica subsp. enterica serovar Typhimurium, Spodoptera frugiperda, Spodoptera frugiperda Sf9
Cheung, E.; D'Ari, L.; Rabinowitz, J.C.; Dyer, D.H.; Huang, J.Y.; Stoddard, B.L.
Purification, crystallization, and preliminary X-ray studies of a bifunctional 5,10-methenyl/methylene tetrahydrofolate cyclohydrolase/dehydrogenase from Escherichia coli
Proteins
27
322-324
1997
Saccharomyces cerevisiae, Drosophila melanogaster, Escherichia coli, Homo sapiens, Rattus norvegicus, Escherichia coli BE
Shen, B.W.; Dyer, D.H.; Huang, J.Y.; D'Ari, L.; Rabinowitz, J.; Stoddard, B.L.
The crystal structure of a bacterial, bifunctional 5,10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
Protein Sci.
8
1342-1349
1999
Escherichia coli
Pomper, B.K.; Vorholt, J.A.; Chistoserdova, L.; Lidstrom, M.E.; Thauer, R.K.
A methenyl tetrahydromethanopterin cyclohydrolase and a methenyl tetrahydrofolate cyclohydrolase in Methylobacterium extorquens AM1
Eur. J. Biochem.
261
475-480
1999
Methylorubrum extorquens
Schmidt, A.; Wu, H.; MacKenzie, R.E.; Chen, V.J.; Bewly, J.R.; Ray, J.E.; Toth, J.E; Cygler, M.
Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase
Biochemistry
39
6325-6335
2000
Drosophila melanogaster, Mus musculus, Rattus norvegicus, Homo sapiens (P11586), Homo sapiens
Pawelek, P.D.; MacKenzie, R.E.
Methenyltetrahydrofolate cyclohydrolase is rate limiting for the enzymatic conversion of 10-formyltetrahydrofolate to 5,10-methylenetetrahydrofolate in bifunctional dehydrogenase-cyclohydrolase enzymes
Biochemistry
37
1109-1115
1998
Saccharomyces cerevisiae, Homo sapiens, Mus musculus, Photobacterium phosphoreum, Sus scrofa
Smith, G.K.; Mueller, W.T.; Wasserman, G.F.; Taylor, W.D.; Benkovic, S.J.
Characterization of the enzyme complex involving the folate-requiring enzymes of de novo purine biosynthesis
Biochemistry
19
4313-4321
1980
Gallus gallus
Baggott, J.E.; MacKenzie, R.E.
5,10-methenyltetrahydrofolate cyclohydrolase, rat liver and chemically catalysed formation of 5-formyltetrahydrofolate
Biochem. J.
374
773-778
2003
Rattus norvegicus
Pawelek, P.D.; Allaire, M.; Cygler, M.; MacKenzie, R.E.
Channeling efficiency in the bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase domain: the effects of site-directed mutagenesis of NADP binding residues
Biochim. Biophys. Acta
1479
59-68
2000
Homo sapiens
Sundararajan, S.; MacKenzie, R.E.
Residues involved in the mechanism of the bifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase: The roles of glutamine 100 and aspartate 125
J. Biol. Chem.
277
18703-18709
2002
Homo sapiens (P11586), Homo sapiens
Konrad, C.; Mueller, G.A.; Langer, C.; Kuhlenbaeumer, G.; Berger, K.; Nabavi, D.G.; Dziewas, R.; Stoegbauer, F.; Ringelstein, E.B.; Junker, R.
Plasma homocysteine, MTHFR C677T, CBS 844ins68bp, and MTHFD1 G1958A polymorphisms in spontaneous cervical artery dissections
J. Neurol.
251
1242-1248
2004
Homo sapiens
Parle-McDermott, A.; Pangilinan, F.; Mills, J.L.; Signore, C.C.; Molloy, A.M.; Cotter, A.; Conley, M.; Cox, C.; Kirke, P.N.; Scott, J.M.; Brody, L.C.
A polymorphism in the MTHFD1 gene increases a mothers risk of having an unexplained second trimester pregnancy loss
Mol. Hum. Reprod.
11
477-480
2005
Homo sapiens
Kim, J.H.; Sung, M.W.; Lee, E.H.; Nam, K.H.; Hwang, K.Y.
Crystallization and preliminary X-ray diffraction analysis of 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase from Thermoplasma acidophilum DSM 1728
J. Microbiol. Biotechnol.
18
283-286
2008
Thermoplasma acidophilum DSM 1728
Christensen, K.E.; Rohlicek, C.V.; Andelfinger, G.U.; Michaud, J.; Bigras, J.L.; Richter, A.; Mackenzie, R.E.; Rozen, R.
The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects
Hum. Mutat.
30
212-220
2009
Homo sapiens (P11586)
Murta, S.M.; Vickers, T.J.; Scott, D.A.; Beverley, S.M.
Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major
Mol. Microbiol.
71
1386-1401
2009
Leishmania major
Christensen, K.E.; Mackenzie, R.E.
Mitochondrial methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase, and formyltetrahydrofolate synthetases
Vitam. Horm.
79
393-410
2008
Homo sapiens, Saccharomyces cerevisiae (P07245), Saccharomyces cerevisiae (P09440)
Pike, S.T.; Rajendra, R.; Artzt, K.; Appling, D.R.
Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos
J. Biol. Chem.
285
4612-4620
2010
Mus musculus
Vickers, T.; Murta, S.; Mandell, M.; Beverley, S.
The enzymes of the 10-formyl-tetrahydrofolate synthetic pathway are found exclusively in the cytosol of the trypanosomatid parasite Leishmania major
Mol. Biochem. Parasitol.
166
142-152
2009
Leishmania infantum, Leishmania major, Leishmania donovani (B8Y658), Leishmania donovani (B8Y659)
Kruszyna, L.; Lianeri, M.; Rydzanicz, M.; Gajecka, M.; Szyfter, K.; Jagodzinski, P.P.
Polymorphic variants of folate metabolism genes and the risk of laryngeal cancer
Mol. Biol. Rep.
37
241-247
2010
Homo sapiens
Lee, W.H.; Sung, M.W.; Kim, J.H.; Kim, Y.K.; Han, A.; Hwang, K.Y.
Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase from Thermoplasma acidophilum
Biochem. Biophys. Res. Commun.
406
459-463
2011
Thermoplasma acidophilum (Q05213), Thermoplasma acidophilum
Eadsforth, T.C.; Cameron, S.; Hunter, W.N.
The crystal structure of Leishmania major N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target
Mol. Biochem. Parasitol.
181
178-185
2012
Leishmania major (Q4Q9F9), Leishmania major
Buchenau, B.; Thauer, R.K.
Tetrahydrofolate-specific enzymes in Methanosarcina barkeri and growth dependence of this methanogenic archaeon on folic acid or p-aminobenzoic acid
Arch. Microbiol.
182
313-325
2004
Methanosarcina barkeri (Q46A53), Methanosarcina barkeri DSM 804 (Q46A53)
Shin, M.; Bryant, J.D.; Momb, J.; Appling, D.R.
Mitochondrial MTHFD2L is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase expressed in both adult and embryonic tissues
J. Biol. Chem.
289
15507-15517
2014
Mus musculus
Eadsforth, T.C.; Gardiner, M.; Maluf, F.V.; McElroy, S.; James, D.; Frearson, J.; Gray, D.; Hunter, W.N.
Assessment of Pseudomonas aeruginosa N5,N10-methylenetetrahydrofolate dehydrogenase-cyclohydrolase as a potential antibacterial drug target
PLoS ONE
7
e35973
2012
Pseudomonas aeruginosa (Q9I2U6), Pseudomonas aeruginosa
Aluri, S.; Sah, S.; Miryala, S.; Varshney, U.
Physiological role of FolD (methylenetetrahydrofolate dehydrogenase), FchA (methenyltetrahydrofolate cyclohydrolase) and Fhs (formyltetrahydrofolate synthetase) from Clostridium perfringens in a heterologous model of Escherichia coli
Microbiology
162
145-155
2016
Clostridium perfringens (A0A2X2Y2S3), Clostridium perfringens
Sah, S.; Varshney, U.
Impact of mutating the key residues of a bifunctional 5,10-methylenetetrahydrofolate dehydrogenase-cyclohydrolase from Escherichia coli on its activities
Biochemistry
54
3504-3513
2015
Escherichia coli (P24186), Escherichia coli, Escherichia coli K12 (P24186)
Shin, M.; Momb, J.; Appling, D.R.
Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase
Cancer Metab.
5
11
2017
Homo sapiens (P13995), Homo sapiens (Q9H903), Homo sapiens
Gustafsson, R.; Jemth, A.S.; Gustafsson, N.M.; Faernegardh, K.; Loseva, O.; Wiita, E.; Bonagas, N.; Dahllund, L.; Llona-Minguez, S.; Haeggblad, M.; Henriksson, M.; Andersson, Y.; Homan, E.; Helleday, T.; Stenmark, P.
Crystal structure of the emerging cancer target MTHFD2 in complex with a substrate-based inhibitor
Cancer Res.
77
937-948
2017
Homo sapiens (P13995), Homo sapiens
Hitzel, J.; Lee, E.; Zhang, Y.; Bibli, S.I.; Li, X.; Zukunft, S.; Pflueger, B.; Hu, J.; Schuermann, C.; Vasconez, A.E.; Oo, J.A.; Kratzer, A.; Kumar, S.; Rezende, F.; Josipovic, I.; Thomas, D.; Giral, H.; Schreiber, Y.; Geisslinger, G.; Fork, C.; Yang, X.; Sigala, F.; Romanoski, C.E.; Kroll, J.; Jo, H.; Lan, L.a.n.d.
Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells
Nat. Commun.
9
2292
2018
Homo sapiens (P13995), Homo sapiens
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