Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
dimethyl-L-arginine + H2O
L-citrulline + dimethylamine
L-arginine + H2O
?
-
-
-
?
N,N-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
N-monomethyl-L-arginine + H2O
L-citrulline + methylamine
N5-(methoxycarbamimidoyl)-L-ornithine + H2O
L-citrulline + ?
-
assay at 37°C, 30 min, pH 7.4
-
-
?
N5-(methylcarbamimidoyl)-L-ornithine + H2O
L-citrulline + ?
-
assay at 37°C, 30 min, pH 7.4
-
-
?
N5-[2,5-dihydro-1H-pyrrol-1-yl(imino)methyl]-L-ornithine + H2O
L-citrulline + ?
-
assay at 37°C, 30 min, pH 7.4
-
-
?
NG,NG-dimethyl-L-arginine + H2O
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
NG,NG-dimethyl-L-arginine + H2O
L-citrulline + dimethylamine
NG,NG-dimethyl-L-homoarginine + H2O
?
-
at 2.8% of the activity with NG,NG-dimethyl-L-arginine
-
-
?
NG-amino-L-arginine + H2O
?
-
-
-
?
NG-hydroxy-L-arginine + H2O
?
-
-
-
?
NG-methyl arginine + H2O
L-citrulline + methylamine
-
-
-
-
?
NG-methyl-L-arginine + H2O
?
-
-
-
?
NG-methyl-L-arginine + H2O
L-citrulline + methylamine
NG-monomethyl-L-arginine + H2O
citrulline + methylamine
Ngamma-monomethyl-L-arginine + H2O
L-citrulline + methylamine
Nomega,Nomega'-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
-
-
?
Nomega,Nomega-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
-
-
?
Nomega-monomethyl-L-arginine + H2O
L-citrulline + methylamine
-
-
-
?
S-methyl-L-thiocitrulline + H2O
?
-
-
-
?
S-methyl-L-thiocitrulline + H2O
L-citrulline + methanethiol
S-methyl-L-thiocitrulline + H2O
methanethiol + L-citrulline
additional information
?
-
dimethyl-L-arginine + H2O
L-citrulline + dimethylamine
-
-
-
?
dimethyl-L-arginine + H2O
L-citrulline + dimethylamine
-
-
-
?
dimethyl-L-arginine + H2O
L-citrulline + dimethylamine
-
-
-
?
dimethyl-L-arginine + H2O
L-citrulline + dimethylamine
-
-
-
-
?
dimethyl-L-arginine + H2O
L-citrulline + dimethylamine
-
4 mM, pH 6.5, 37°C, 2 h incubation time
-
-
?
dimethyl-L-arginine + H2O
L-citrulline + dimethylamine
-
-
-
?
N,N-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
-
-
?
N,N-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
-
-
-
?
N,N-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
37°C, 2 h, pH 6.0
-
-
?
N-monomethyl-L-arginine + H2O
L-citrulline + methylamine
-
-
-
-
?
N-monomethyl-L-arginine + H2O
L-citrulline + methylamine
-
-
-
-
?
N-monomethyl-L-arginine + H2O
L-citrulline + methylamine
-
-
-
-
?
NG,NG-dimethyl-L-arginine + H2O
?
-
-
-
-
?
NG,NG-dimethyl-L-arginine + H2O
?
-
-
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
-
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
enzyme is involved in regulation of the levels of the natural occuring free arginine derivatives L-Nomega,Nomega-dimethylarginine and L-Nomega-methylarginine, which are reversible inhibitors of nitric oxide synthase
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
-
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
-
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
the key role of dimethylarginine dimethylaminohydrolase may be to ensure that under normal conditions the levels of methylarginines are kept low throughout the whole cell
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
enzyme plays an integral role in arginine handling
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
the enzyme plays a functional role in the regulation of nitric oxide synthase
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
the enzyme might play a role as a regulator of nitric oxide generation in human tissues
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
-
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
enzyme plays an integral role in arginine handling
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
-
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
-
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
-
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
-
-
ir
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
enzyme plays an integral role in arginine handling
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
enzyme plays a role in metabolism of NG,NG-dimethyl-L-arginine
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
the enzyme plays a functional role in the regulation of nitric oxide synthase
-
-
?
NG,NG-dimethyl-L-arginine + H2O
dimethylamine + L-citrulline
-
-
-
-
?
NG,NG-dimethyl-L-arginine + H2O
L-citrulline + dimethylamine
-
-
-
-
?
NG,NG-dimethyl-L-arginine + H2O
L-citrulline + dimethylamine
-
-
-
-
?
NG,NG-dimethyl-L-arginine + H2O
L-citrulline + dimethylamine
-
-
-
-
?
NG-methyl-L-arginine + H2O
L-citrulline + methylamine
-
-
-
-
?
NG-methyl-L-arginine + H2O
L-citrulline + methylamine
-
-
-
-
?
NG-monomethyl-L-arginine + H2O
citrulline + methylamine
-
-
-
-
?
NG-monomethyl-L-arginine + H2O
citrulline + methylamine
-
-
-
-
?
NG-monomethyl-L-arginine + H2O
citrulline + methylamine
-
-
-
?
NG-monomethyl-L-arginine + H2O
citrulline + methylamine
-
at 61% of the activity with NG,NG-dimethyl-L-arginine
-
-
?
Ngamma-monomethyl-L-arginine + H2O
L-citrulline + methylamine
-
-
-
?
Ngamma-monomethyl-L-arginine + H2O
L-citrulline + methylamine
-
-
-
?
Ngamma-monomethyl-L-arginine + H2O
L-citrulline + methylamine
-
-
-
?
Ngamma-monomethyl-L-arginine + H2O
L-citrulline + methylamine
-
-
-
-
?
Ngamma-monomethyl-L-arginine + H2O
L-citrulline + methylamine
-
-
-
?
S-methyl-L-thiocitrulline + H2O
L-citrulline + methanethiol
-
-
-
?
S-methyl-L-thiocitrulline + H2O
L-citrulline + methanethiol
-
-
-
?
S-methyl-L-thiocitrulline + H2O
L-citrulline + methanethiol
-
-
-
?
S-methyl-L-thiocitrulline + H2O
L-citrulline + methanethiol
-
-
-
?
S-methyl-L-thiocitrulline + H2O
L-citrulline + methanethiol
-
-
-
-
?
S-methyl-L-thiocitrulline + H2O
L-citrulline + methanethiol
-
-
-
?
S-methyl-L-thiocitrulline + H2O
methanethiol + L-citrulline
-
-
-
-
?
S-methyl-L-thiocitrulline + H2O
methanethiol + L-citrulline
-
-
-
-
?
additional information
?
-
no hydrolysis of NG,NG-dimethyl-L-arginine
-
-
?
additional information
?
-
-
no hydrolysis of NG,NG-dimethyl-L-arginine
-
-
?
additional information
?
-
-
incapable of hydrolyzing peptide incorporated methylarginines
-
-
?
additional information
?
-
-
L-arginine is no substrate
-
-
?
additional information
?
-
no substrate: S-ethyl-2-thiopseudourea, S-ethyl-N-phenylisothiourea and phenylene-1,3-bis(ethane-2-isothiourea)
-
-
?
additional information
?
-
-
no substrate: S-ethyl-2-thiopseudourea, S-ethyl-N-phenylisothiourea and phenylene-1,3-bis(ethane-2-isothiourea)
-
-
?
additional information
?
-
-
DDAH1 forms a protein complex with Ras
-
-
?
additional information
?
-
bad substrates are creatine, creatinine, argininosuccinate, guanidinoacetate, L-homoarginine, L-canvanine
-
-
?
additional information
?
-
-
bad substrates are creatine, creatinine, argininosuccinate, guanidinoacetate, L-homoarginine, L-canvanine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2S)-2-amino-5-(ethanimidoylamino)pentanoic acid
-
-
(2S)-2-amino-5-(N'-butylcarbamimidamido)pentanoic acid
-
-
(2S)-2-amino-5-(pent-4-enimidoylamino)pentanoic acid
-
-
(2S)-2-amino-5-(pentanimidoylamino)pentanoic acid
-
-
(2S)-2-amino-5-(propanimidoylamino)pentanoic acid
-
-
(2S)-2-amino-5-[(4E)-hex-4-enimidoylamino]pentanoic acid
-
-
(2S)-2-amino-5-[N'-(3,3,3-trifluoropropyl)carbamimidamido]pentanoic acid
-
-
(2S)-2-amino-5-[N'-(3-methoxypropyl)carbamimidamido]pentanoic acid
-
-
(2S)-2-amino-5-[N'-(4-amino-4-oxobutyl)carbamimidamido]pentanoic acid
-
-
(2S)-2-amino-5-[N'-(but-3-en-1-yl)carbamimidamido]pentanoic acid
-
-
(2S)-2-amino-5-[N'-(but-3-yn-1-yl)carbamimidamido]pentanoic acid
-
-
(2S)-2-amino-5-[N'-(nitromethyl)carbamimidamido]pentanoic acid
-
-
(2S)-2-amino-5-[N'-(pent-4-en-1-yl)carbamimidamido]pentanoic acid
-
-
2,3-dimethoxy-1,4-naphthoquinone
-
1 mM
2-(N,N-diethylamino)-diazenolate-2-oxide
-
1 mM
2-(N,N-dimethylamino)-diazenolate-2-oxide
2-(N,N-dimethylamino)diazenolate-2-oxide
2-amino-4-(NG-methyl-guanidino)butanoic acid
2-chloroacetamidine
irreversible inhibition in a time- and concentration-dependent manner
2-hydroxymethyl-4-chloropyridine
-
solution studies support an inactivation mechanismin in which the active site Asp66 residue stabilizes the pyridinium form of the inactivator, which has enhanced reactivity toward the active site Cys, resulting in covalent bond formation, loss of the halide, and irreversible inactivation
4-hydroxy-2-nonenal
50 microM, 50% relative activity
4-hydroxy-nonenal
-
dose-dependently inhibits DDAH activity with 15% inhibition at 0.01 mM and complete inhibition at 0.5 mM
angiotensin II
1 microM, about 55% relative activity; 1 microM, about 55% relative activity
aprotinin inhibitor
-
NG,NG-dimethyl-L-arginine release from freeze-thaw whole blood 34% inhibited
-
cytokine induced nitric-oxide synthesis
-
-
D-arginine
-
0.1 mM D-arginine reduces DDAH activity to 24.7%
darbepoetin alpha
-
inhibits DDAH in a dose dependent manner, inhibition of DDAH is abolished by incubation with EPO antibody or with antioxidant pyrrolidine dithiocarbamate
-
epoetin beta
-
inhibits DDAH in a dose dependent manner, inhibition of DDAH is abolished by incubation with EPO antibody or with antioxidant pyrrolidine dithiocarbamate
-
erythropoetin
200 units/ml, about 75% relative activity; 200 units/ml, about 75% relative activity
-
glycosylated bovine serum albumin
-
-
H2O2
-
43% inhibition at 1 mM
hydrogen peroxide
100 microM, 50% relative activity
iodoacetamide
-
pH dependent DDAH inactivation, addition of 2.5 mM NG-methyl-L-arginine at pH 8.5 can prevent inactivation by idoacetamide, inactivation may be due to modification at the active site of DDAH, inactivation increases at higher pH values
L-lysine
-
competitive inhibitor; potential competitive inhibitor
leupeptin
-
NG,NG-dimethyl-L-arginine release from freeze-thaw whole blood 55% inhibited
lipopolysaccharide
1 microg/ml, 24 h, about 55% relative activity; 1 microg/ml, about 55% relative activity
low-density-lipoprotein
100 microg/ml
-
methylamine
-
10 mM, 80% of activity
monocrotaline
-
DDAH activity and DDAH1, but not DDAH2, protein expression are significantly reduced after 60mg/kg monocrotaline treatment
N(G)-nitro-L-arginine methyl ester
-
reduced DDAH-2 mRNA level
N-(2-methoxyethyl)-L-arginine
complete inhibition at 100 microM; complete inhibition at 100 microM
N-(2-methoxyethyl)arginine
-
N-(2-methoxyethyl)arginine methyl esther
-
N-(but-3-yn-1-yl)-2-chloroethanimidamide
-
click chemistry mediated in vivo activity probe that labels the active fraction of DDAH-1 in intact mammalian cells and that can be blocked by the presence of competitive reversible and irreversible inhibitors
N-nitro-L-arginine methylester
N5-(1-iminoethyl)-L-ornithine
-
N5-(1-iminohexyl)-L-ornithine
-
N5-(1-iminopentyl)-L-ornithine
-
N5-(1-iminopropyl)-L-ornithine
crystallization data. Reversible competitive inhibition, consistent with a reversible covalent mode of DDAH inhibition by alkylamidine inhibitors
N5-(but-3-en-1-ylcarbamimidoyl)-L-ornithine
-
1 mM, 71% inhibition
N5-(nitrocarbamimidoyl)-L-ornithine
-
1 mM, 6% inhibition
N5-(prop-2-en-1-ylcarbamimidoyl)-L-ornithine
-
1 mM, 70% inhibition
N5-(prop-2-yn-1-ylcarbamimidoyl)-L-ornithine
-
1 mM, 83% inhibition
N5-(propylcarbamimidoyl)-L-ornithine
-
1 mM, 60% inhibition
N5-but-3-enimidoyl-L-ornithine
-
1 mM, 97% inhibition
N5-butanimidoyl-L-ornithine
-
1 mM, 78% inhibition
N5-ethanimidoyl-L-ornithine
-
1 mM, 24% inhibition
N5-propanimidoyl-L-ornithine
-
1 mM, 65% inhibition
N5-[(2,2,2-trifluoroethyl)carbamimidoyl]-L-ornithine
-
1 mM, 41% inhibition
N5-[(2-methoxyethyl)carbamimidoyl]-L-ornithine
-
1 mM, 89% inhibition
N5-[(3-amino-3-oxopropyl)carbamimidoyl]-L-ornithine
-
1 mM, 43% inhibition
N5-[(3E)-pent-3-enimidoyl]-L-ornithine
-
1 mM, 73% inhibition
N5-[imino(morpholin-4-yl)methyl]-L-ornithine
-
1 mM, 23% inhibition
Nicotine
50% decrease in DDAH-2 mRNA
nitroglycerine
10 microM, 16 h, about 55% relative activity; 10 microM, about 55% relative activity
OH radical
-
47% inhibition at 1 mM
oxidized-low density lipoprotein
-
PD 404182
i.e. 6H-6-imino-(2,3,4,5-tetrahydropyrimido)[1,2-c]-[1,3]benzothiazine, potent active-site competitive inhibitor, about 75% inhibition at 0.05 mM
pentafluorophenyl sulfonates
-
between 30-76% DDAH inhibition depending on molecular structure of the pentafluoropenyl sulfonate
-
PMSF
-
NG,NG-dimethyl-L-arginine release from freeze-thaw whole blood 57% inhibited
protease inhibitor
-
NG,NG-dimethyl-L-arginine release from freeze-thaw whole blood 25-85% inhibited
-
S-2-amino-4(3-methylguanidino)butanoic acid
S-2-amino-4-[N-(2-methoxyethyl)guanidino]butanoic acid benzyl ester
-
S-nitroso-L-cysteine
9-15% inhibition of the zinc-free enzyme at 0.5 mM, S-nitrosylation of the active site Cys273 in DDAH-1
sulfurosalicylic acid
-
inactivates DDAH
TNF-alpha
250 U/ml, 63% relative activity
-
2-(N,N-dimethylamino)-diazenolate-2-oxide
-
S-nitrosylation of apo-enzyme, holo-enzyme resists, reaction with two of five Cys-residues
2-(N,N-dimethylamino)-diazenolate-2-oxide
-
i.e. DEANONOate, inhibition by S-nitrosylation, reversed by dithiothreitol
2-(N,N-dimethylamino)-diazenolate-2-oxide
-
i.e. DEANONOate, inhibition by S-nitrosylation, reversed by dithiothreitol
2-(N,N-dimethylamino)diazenolate-2-oxide
1 mM, 50% inhibition of DDAH-1
2-(N,N-dimethylamino)diazenolate-2-oxide
1 mM, 50% inhibition of DDAH-1; 1 mM, 50% inhibition of DDAH-1
2-(N,N-dimethylamino)diazenolate-2-oxide
1 mM, 50% inhibition of DDAH-1
2-amino-4-(NG-methyl-guanidino)butanoic acid
-
incubation of lysed red blood cells, dose dependent inhibition of NG,NG-dimethyl-L-arginine degradation with the highest dose (1 mM) reversing the pattern to a net increase in NG,NG-dimethyl-L-arginine concentration for the 1- and 3h time points
2-amino-4-(NG-methyl-guanidino)butanoic acid
-
a series of analogues designed, reversible DDAH inhibitors
glucose
-
glucose
25.5 mmol/l; 25.5 mmol/l
glucose
25.5 mmol/l; 25.5 mmol/l
homocysteine
-
homocysteine
-
inhibition of the expression of DDAH-2 reduces the NO production induced by IL-1beta
L-arginine
-
0.1 mM L-arginine competitively inhibits DDAH enzyme activity to 5.6%
L-citrulline
-
L-citrulline
-
competitive
L-homocysteine
-
lysophosphatidylcholine
-
-
lysophosphatidylcholine
10 microg/ml, about 35% relative activity
lysophosphatidylcholine
-
activity is significantly decreased in cells treated with lysophosphatidylcholine (0.005 mg/ml) for 48 h, 0.001-0.005 mM probucol or 0.001 mM pyrrolidindithiocarbamate significantly attenuate inhibition of DDAH activity by lysophosphatidylcholine
N-nitro-L-arginine methylester
1 mM, 1 h, 47.1% relative activity; 1mM, 1 h, 47.1% relative activity
N-nitro-L-arginine methylester
1mM, 1 h, 47.1% relative activity
N-nitro-L-arginine methylester
-
N-nitro-L-arginine methylester
-
1 mM, 1 h, 47.1% relative activity
N-nitro-L-arginine methylester
-
nitric oxide
-
nitric oxide
increased NO production nitrosates DDAH
oxidized-low density lipoprotein
-
-
-
oxidized-low density lipoprotein
-
activity is significantly decreased in cells treated with oxidized-low density lipoprotein (0.1 mg/ml) for 48 h, 0.001-0.005 mM probucol or 0.001 mM pyrrolidindithiocarbamat significantly attenuate inhibition of DDAH activity by oxidized-low density lipoprotein
-
peroxynitrite
-
inhibition of 15% after exposure to peroxynitrite at concentrations ranging from 0.01-0.1 mM, 25% inhibition at 1 mM
S-2-amino-4(3-methylguanidino)butanoic acid
-
-
S-2-amino-4(3-methylguanidino)butanoic acid
-
-
S-nitroso-L-homocysteine
-
S-nitroso-L-homocysteine
96% inhibition of the zinc-free enzyme at 0.5 mM, leads to the unique formation of an N-thiosulfoximide
S-nitroso-L-homocysteine
-
-
Zn2+
-
besides the tightly bound zinc, additional Zn2+ inhibit competitively
Zn2+
-
endogenous inhibitor, regulatory role
Zn2+
-
one mol per mol of enzyme, apo-enzyme is active, holoenzyme is activated by removal of Zn2+
Zn2+
20 microM, 40% relative activity; 20 microM, 40% relative activity
Zn2+
-
incubation of lysed red blood cells, diminished hydrolyis of NG,NG-dimethyl-L-arginine by addition of physiologically relevant concentrations (0.02 mM)
additional information
5 mM of L-cysteine, L-homocysteine, glutathione, dithiothreitol, or Tris(2-carboxyethyl)phosphine-HCl for 30 min at 37°C cannot restore inhibited activity, suggesting that the covalent product N-thiosulfoximide will remain stable under the reducing conditions present in the cytosol
-
additional information
-
exposure to pathophysiological levels of reactive oxygen has little to no effect on the activity of the enzyme
-
additional information
-
insensitive to hydrogen peroxide
-
additional information
S-ethyl-2-thiopseudourea, S-ethyl-N-phenylisothiourea and phenylene-1,3-bis(ethane-2-isothiourea) do not inhibit DDAH-1 at concentrations below 1 mM
-
additional information
-
S-ethyl-2-thiopseudourea, S-ethyl-N-phenylisothiourea and phenylene-1,3-bis(ethane-2-isothiourea) do not inhibit DDAH-1 at concentrations below 1 mM
-
additional information
-
tissue-specific decrease of levels of Ddah1 and Ddah2 RNA after feeding a high-methionine/low-folate diet for 5 to 11 month
-
additional information
not inhibited by 2-chloroacetamide
-
additional information
-
not inhibited by 2-chloroacetamide
-
additional information
-
incubation of lysed red blood cells with EDTA or glucose failed to attenuate the degradation of NG,NG-dimethyl-L-arginine, incubation of whole blood cells with arginine methyltransferase inhibitors does not reduce NG,NG-dimethyl-L-arginine release
-
additional information
-
probucol or pyrrolidindithiocarbamate itself have no effect on the activity of DDAH
-
additional information
-
decrease of DDAH-2 mRNA level induced by 10% serum, ionomycin or endothelial growth factors
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Leiper, J.M.; Santa Maria, J.; Chubb, A.; MacAllister, R.J.; Charles, I.G.
Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases
Biochem. J.
343
209-214
1999
Homo sapiens (O95865), Homo sapiens
brenda
Kimoto, M.; Sasakawa, T.; Tsuji, H.; Miyatake, S.; Oka, T.
Cloning and sequencing of cDNA encoding NG,NG-dimethylarginine dimethylaminohydrolase from rat kidnes
Biochim. Biophys. Acta
1337
6-10
1997
Rattus norvegicus
brenda
Santa Maria, J.; Vallance, P.; Charles, I.G.; Leiper, J.M.
Identification of microbial dimethylarginine dimethylaminohydrolase enzymes
Mol. Microbiol.
33
1278-1279
1999
Homo sapiens, Mycobacterium tuberculosis, Mus musculus, Pseudomonas aeruginosa, Rattus norvegicus, Streptomyces coelicolor
brenda
Birdsey, G.M.; Leiper, J.M.; Vallance, P.
Intramolecular localization of dimethylarginine dimethylaminohydrolase overexpressed in an endothelial cell line
Acta Physiol. Scand.
168
73-79
2000
Homo sapiens
brenda
Bogumil, R.; Knipp, M.; Fundel, S.M.; Vasak, M.
Characterization of dimethylargininase from bovine brain: evidence for a zinc binding site
Biochemistry
37
4791-4798
1998
Bos taurus
brenda
MacAllister, R.J.; Parry, H.; Kimoto, M.; Ogawa, T.; Russell, R.J.; Hodson, H.; Whiteley, G.St.J.; Vallance, P.
Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase
Br. J. Pharmacol.
119
1533-1540
1996
Homo sapiens, Rattus norvegicus
brenda
Ogawa, T.; Kimoto, M.; Sasaoka, K.
Purification and properties of a new enzyme, NG,NG-dimethylarginine dimethylaminohydrolase from rat kidney
J. Biol. Chem.
264
10205-10209
1989
Rattus norvegicus
brenda
Kimoto, M.; Whiteley, G.St.J.; Tsuji, H.; Ogawa, T.
Detection of NG,NG-dimethylarginine dimethylaminohydrolase in human tissue using a monoclonal antibody
J. Biochem.
117
237-238
1995
Homo sapiens
brenda
Kimoto, M.; Tsuji, H.; Ogawa, T.; Sasaoka, K.
Detection of NG,NG-dimethylarginine dimethylaminohydrolase in the nitric oxide-generating systems of rats using monoclonal antibody
Arch. Biochem. Biophys.
300
657-662
1993
Rattus norvegicus
brenda
Knipp, M.; Charnock, J.M.; Garner, C.D.; Vasak, M.
Structural and functional characterization of the Zn(II) site in dimethylargininase-1 (DDAH-1) from bovine brain. Zn(II) release activates DDAH-1
J. Biol. Chem.
276
40449-40456
2001
Bos taurus
brenda
Knipp, M.; Braun, O.; Gehrig, P.M.; Sack, R.; Vasak, M.
Zn(II)-free dimethylargininase-1 (DDAH-1) is inhibited upon specific Cys-S-nitrosylation
J. Biol. Chem.
278
3410-3416
2003
Bos taurus
brenda
Plevin, M.J.; Magalhaes, B.S.; Harris, R.; Sankar, A.; Perkins, S.J.; Driscoll, P.C.
Characterization and manipulation of the Pseudomonas aeruginosa dimethylarginine dimethylaminohydrolase monomer--dimer equilibrium
J. Mol. Biol.
341
171-184
2004
Pseudomonas aeruginosa (Q9I4E3), Pseudomonas aeruginosa
brenda
Leiper, J.; Murray-Rust, J.; McDonald, N.; Vallance, P.
S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase
Proc. Natl. Acad. Sci. USA
99
13527-13532
2002
Homo sapiens, Pseudomonas aeruginosa
brenda
Stone, E.M.; Schaller, T.H.; Bianchi, H.; Person, M.D.; Fast, W.
Inactivation of two diverse enzymes in the amidinotransferase superfamily by 2-chloroacetamidine: dimethylargininase and peptidylarginine deiminase
Biochemistry
44
13744-13752
2005
Pseudomonas aeruginosa (Q9I4E3), Pseudomonas aeruginosa
brenda
Chen, Y.; Li, Y.; Zhang, P.; Traverse, J.H.; Hou, M.; Xu, X.; Kimoto, M.; Bache, R.J.
Dimethylarginine dimethylaminohydrolase and endothelial dysfunction in failing hearts
Am. J. Physiol. Heart Circ. Physiol.
289
H2212-2219
2005
Canis lupus familiaris, Homo sapiens
brenda
Billecke, S.S.; Kitzmiller, L.A.; Northrup, J.J.; Whitesall, S.E.; Kimoto, M.; Hinz, A.V.; D'Alecy, L.G.
Contribution of whole blood to the control of plasma asymmetrical dimethylarginine
Am. J. Physiol. Heart Circ. Physiol.
291
H1788-1796
2006
Rattus norvegicus
brenda
Hasegawa, K.; Wakino, S.; Tanaka, T.; Kimoto, M.; Tatematsu, S.; Kanda, T.; Yoshioka, K.; Homma, K.; Sugano, N.; Kurabayashi, M.; Saruta, T.; Hayashi, K.
Dimethylarginine dimethylaminohydrolase 2 increases vascular endothelial growth factor expression through Sp1 transcription factor in endothelial cells
Arterioscler. Thromb. Vasc. Biol.
26
1488-1494
2006
Bos taurus, Homo sapiens
brenda
Yin, Q.; Fu, S.; He, P.; Xiong, Y.
Dimethylarginine dimethylaminohydrolase inhibition and asymmetric dimethylarginine accumulation contribute to endothelial dysfunction in rats exposed to glycosylated protein: Effects of aminoguanidine
Atherosclerosis
190
53-61
2006
Rattus norvegicus
brenda
Stone, E.M.; Person, M.D.; Costello, N.J.; Fast, W.
Characterization of a transient covalent adduct formed during dimethylarginine dimethylaminohydrolase catalysis
Biochemistry
44
7069 - 7078
2005
Pseudomonas aeruginosa (Q9I4E3), Pseudomonas aeruginosa
brenda
Stone, E.M.; Costello, A.L.; Tierney, D.L.; Fast, W.
Substrate-assisted cysteine deprotonation in the mechanism of dimethylargininase (DDAH) from Pseudomonas aeruginosa
Biochemistry
45
5618-5630
2006
Pseudomonas aeruginosa
brenda
Mishima, T.; Hamada, T.; Ui-Tei, K.; Miyata, Y.; Imaki, J.; Suzuki, H.; Yamashita K.
Expression of DDAH1 in chick and rat embryos
Brain Res. Dev. Brain Res.
148
223-232
2004
Gallus gallus, Rattus norvegicus
brenda
Jiang, J.L.; Zhang, X.H.; Li, N.S.; Rang, W.Q; Feng-Ye, W.Q.; Hu, C.P.; Li, Y.J.; Deng, H.W.
Probucol decreases asymmetrical dimethylarginine level by alternation of protein arginine methyltransferase I and dimethylarginine dimethylaminohydrolase activity
Cardiovasc. Drugs Ther.
20
281-294
2006
Homo sapiens, Rattus norvegicus
brenda
Vallance, P.; Bush, H.D.; Mok, B.J.; Hurtado-Guerrero, R.; Gill, H.; Rossiter, S.; Wilden, J.D.; Caddick, S.
Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates
Chem. Commun. (Camb.)
2005
5563-5565
2005
Pseudomonas sp.
brenda
Wakino, S.; Hayashi, K.; Tatematsu, S.; Hasegawa, K.; Takamatsu, I.; Kanda, T.; Homma, K.; Yoshioka, K.; Sugano, N.; Saruta, T.
Pioglitazone lowers systemic asymmetric dimethylarginine by inducing dimethylarginine dimethylaminohydrolase in rats
Hypertens. Res.
28
255-262
2005
Rattus norvegicus
brenda
Scalera, F.; Kielstein, J.T.; Martens-Lobenhoffer, J.; Postel, S.C.; Tager, M.; Bode-Boger, S.M.
Erythropoietin increases asymmetric dimethylarginine in endothelial cells: role of dimethylarginine dimethylaminohydrolase
J. Am. Soc. Nephrol.
16
892-898
2005
Homo sapiens
brenda
Rossiter, S.; Smith, C.L.; Malaki, M.; Nandi, M.; Gill, H.; Leiper, J.M.; Vallance, P.; Selwood, D.L.
Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase
J. Med. Chem.
48
4670-4678
2005
Rattus norvegicus
brenda
Frey, D.; Braun, O.; Briand, C.; Vak, M.; Grtter, M.G.
Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: a basis for the design of specific inhibitors
Structure
14
901-911
2006
Bos taurus (P56965), Bos taurus
brenda
Braun, O.; Knipp, M.; Chesnov, S.; Vasak, M.
Specific reactions of S-nitrosothiols with cysteine hydrolases: A comparative study between dimethylargininase-1 and CTP synthetase
Protein Sci.
16
1522-1534
2007
Bos taurus (P56965)
brenda
Sasaki, A.; Doi, S.; Mizutani, S.; Azuma, H.
Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats
Am. J. Physiol. Lung Cell Mol. Physiol.
292
L1480-L1487
2007
Rattus norvegicus
brenda
Forbes, S.P.; Druhan, L.J.; Guzman, J.E.; Parinandi, N.; Zhang, L.; Green-Church, K.B.; Cardounel, A.J.
Mechanism of 4-HNE mediated inhibition of hDDAH-1: implications in no regulation
Biochemistry
47
1819-1826
2008
Homo sapiens
brenda
Wang, J.; Sim, A.S.; Wang, X.L.; Wilcken, D.E.
L-arginine regulates asymmetric dimethylarginine metabolism by inhibiting dimethylarginine dimethylaminohydrolase activity in hepatic (HepG2) cells
Cell. Mol. Life Sci.
63
2838-2846
2006
Homo sapiens
brenda
Wang, D.; Gill, P.S.; Chabrashvili, T.; Onozato, M.L.; Raggio, J.; Mendonca, M.; Dennehy, K.; Li, M.; Modlinger, P.; Leiper, J.; Vallance, P.; Adler, O.; Leone, A.; Tojo, A.; Welch, W.J.; Wilcox, C.S.
Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO
Circ. Res.
101
627-635
2007
Rattus norvegicus (Q6MG60)
brenda
Siroen, M.P.; Teerlink, T.; Bolte, A.C.; van Elburg, R.M.; Richir, M.C.; Nijveldt, R.J.; van der Hoven, B.; van Leeuwen, P.A.
No compensatory upregulation of placental dimethylarginine dimethylaminohydrolase activity in preeclampsia
Gynecol. Obstet. Invest.
62
7-13
2006
Homo sapiens
brenda
Hong, L.; Fast, W.
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia
J. Biol. Chem.
282
34684-34692
2007
Homo sapiens
brenda
Slaghekke, F.; Dekker, G.; Jeffries, B.
Endogenous inhibitors of nitric oxide and preeclampsia: a review
J. Matern. Fetal. Neonatal. Med.
19
447-452
2006
Homo sapiens (O95865), Homo sapiens
brenda
Tain, Y.L.; Baylis, C.
Determination of dimethylarginine dimethylaminohydrolase activity in the kidney
Kidney Int.
72
886-889
2007
Rattus norvegicus
brenda
Mizuno, Y.; Isotani, E.; Ohno, K.; Nagai, A.; Imamura, M.; Azuma, H.
Involvement of accumulated NOS inhibitors and endothelin-1, enhanced arginase, and impaired DDAH activities in pulmonary dysfunction following subarachnoid hemorrhage in the rabbit
Vascul. Pharmacol.
48
21-31
2008
Oryctolagus cuniculus
brenda
Dayal, S.; Rodionov, R.N.; Arning, E.; Bottiglieri, T.; Kimoto, M.; Murry, D.J.; Cooke, J.P.; Faraci, F.M.; Lentz, S.R.
Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia
Am. J. Physiol. Heart Circ. Physiol.
295
H816-H825
2008
Mus musculus
brenda
Sydow, K.; Mondon, C.E.; Schrader, J.; Konishi, H.; Cooke, J.P.
Dimethylarginine dimethylaminohydrolase overexpression enhances insulin sensitivity
Arterioscler. Thromb. Vasc. Biol.
28
692-697
2008
Homo sapiens
brenda
Kotthaus, J.; Schade, D.; Muschick, N.; Beitz, E.; Clement, B.
Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads
Bioorg. Med. Chem.
16
10205-10209
2008
Homo sapiens
brenda
Xiao, J.; Xiao, Z.J.; Liu, Z.G.; Gong, H.Y.; Yuan, Q.; Wang, S.; Li, Y.J.; Jiang, D.J.
Involvement of dimethylarginine dimethylaminohydrolase-2 in visfatin-enhanced angiogenic function of endothelial cells
Diabetes Metab. Res. Rev.
25
242-249
2009
Homo sapiens
brenda
Ellger, B.; Richir, M.C.; van Leeuwen, P.A.; Debaveye, Y.; Langouche, L.; Vanhorebeek, I.; Teerlink, T.; Van den Berghe, G.
Glycemic control modulates arginine and asymmetrical-dimethylarginine levels during critical illness by preserving dimethylarginine-dimethylaminohydrolase activity
Endocrinology
149
3148-3157
2008
Oryctolagus cuniculus
brenda
Wadham, C.; Mangoni, A.A.
Dimethylarginine dimethylaminohydrolase regulation: a novel therapeutic target in cardiovascular disease
Expert. Opin. Drug Metab. Toxicol.
5
303-319
2009
Bos taurus, Bos taurus (Q3SX44), Oryctolagus cuniculus, Rattus norvegicus (O08557), Rattus norvegicus (Q6MG60), Homo sapiens (O94760), Homo sapiens (O95865), Mus musculus (Q99LD8), Mus musculus (Q9CWS0)
brenda
Sakurada, M.; Shichiri, M.; Imamura, M.; Azuma, H.; Hirata, Y.
Nitric oxide upregulates dimethylarginine dimethylaminohydrolase-2 via cyclic GMP induction in endothelial cells
Hypertension
52
903-909
2008
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Wang, S.; Hu, C.P.; Jiang, D.J.; Peng, J.; Zhou, Z.; Yuan, Q.; Nie, S.D.; Jiang, J.L.; Li, Y.J.; Huang, K.L.
All-trans retinoic acid inhibits cobalt chloride-induced apoptosis in PC12 cells: role of the dimethylarginine dimethylaminohydrolase/asymmetric dimethylarginine pathway
J. Neurosci. Res.
87
1938-1946
2009
Homo sapiens
brenda
Ueda, S.; Yamagishi, S.I.; Matsumoto, Y.; Kaida, Y.; Fujimi-Hayashida, A.; Koike, K.; Tanaka, H.; Fukami, K.; Okuda, S.
Involvement of asymmetric dimethylarginine (ADMA) in glomerular capillary loss and sclerosis in a rat model of chronic kidney disease (CKD)
Life Sci.
84
853-860
2009
Homo sapiens
brenda
Gray, G.A.; Patrizio, M.; Sherry, L.; Miller, A.A.; Malaki, M.; Wallace, A.F.; Leiper, J.M.; Vallance, P.
Immunolocalisation and activity of DDAH I and II in the heart and modification post-myocardial infarction
Acta Histochem.
112
413-423
2010
Rattus norvegicus
brenda
Lee, W.J.; Kim, S.H.; Kim, G.H.; Han, S.M.; Won, J.C.; Jung, C.H.; Park, H.S.; Choi, d.o..S.; Lee, K.U.; Park, J.Y.
Alpha-lipoic acid activates dimethylarginine dimethylaminohydrolase in cultured endothelial cells
Biochem. Biophys. Res. Commun.
398
653-658
2010
Mus musculus
brenda
Wang, Y.; Monzingo, A.F.; Hu, S.; Schaller, T.H.; Robertus, J.D.; Fast, W.
Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide
Biochemistry
48
8624-8635
2009
Homo sapiens (O94760), Homo sapiens
brenda
Rodionov, R.N.; Dayoub, H.; Lynch, C.M.; Wilson, K.M.; Stevens, J.W.; Murry, D.J.; Kimoto, M.; Arning, E.; Bottiglieri, T.; Cooke, J.P.; Baumbach, G.L.; Faraci, F.M.; Lentz, S.R.
Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia
Circ. Res.
106
551-558
2010
Homo sapiens
brenda
Breckenridge, R.A.; Kelly, P.; Nandi, M.; Vallance, P.J.; Ohun, T.J.; Leiper, J.
A role for dimethylarginine dimethylaminohydrolase 1 (DDAH1) in mammalian development
Int. J. Dev. Biol.
54
215-220
2010
Mus musculus
brenda
Wang, Y.; Hu, S.; Fast, W.
A click chemistry mediated in vivo activity probe for dimethylarginine dimethylaminohydrolase
J. Am. Chem. Soc.
131
15096-15097
2009
Homo sapiens
brenda
Pope, A.J.; Karrupiah, K.; Kearns, P.N.; Xia, Y.; Cardounel, A.J.
Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production
J. Biol. Chem.
284
35338-35347
2009
Bos taurus (P56965), Bos taurus (Q3SX44)
brenda
Li, J.; Wilson, A.; Gao, X.; Kuruba, R.; Liu, Y.; Poloyac, S.; Pitt, B.; Xie, W.; Li, S.
Coordinated regulation of dimethylarginine dimethylaminohydrolase-1 and cationic amino acid transporter-1 by farnesoid X receptor in mouse liver and kidney and its implication in the control of blood levels of asymmetric dimethylarginine
J. Pharmacol. Exp. Ther.
331
234-243
2009
Mus musculus
brenda
Hu, X.; Atzler, D.; Xu, X.; Zhang, P.; Guo, H.; Lu, Z.; Fassett, J.; Schwedhelm, E.; Boeger, R.H.; Bache, R.J.; Chen, Y.
Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine
Arterioscler. Thromb. Vasc. Biol.
31
1540-1546
2011
Mus musculus
brenda
Zhang, P.; Hu, X.; Xu, X.; Chen, Y.; Bache, R.J.
Dimethylarginine dimethylaminohydrolase 1 modulates endothelial cell growth through nitric oxide and Akt
Arterioscler. Thromb. Vasc. Biol.
31
890-897
2011
Homo sapiens, Mus musculus
brenda
Cillero-Pastor, B.; Mateos, J.; Fernandez-Lopez, C.; Oreiro, N.; Ruiz-Romero, C.; Blanco, F.J.
Dimethylarginine dimethylaminohydrolase 2, a newly identified mitochondrial protein modulating nitric oxide synthesis in normal human chondrocytes
Arthritis Rheum.
64
204-212
2012
Homo sapiens
brenda
Johnson, C.M.; Linsky, T.W.; Yoon, D.W.; Person, M.D.; Fast, W.
Discovery of halopyridines as quiescent affinity labels: inactivation of dimethylarginine dimethylaminohydrolase
J. Am. Chem. Soc.
133
1553-1562
2011
Pseudomonas aeruginosa
brenda
Kotthaus, J.; Schade, D.; Kotthaus, J.; Clement, B.
Designing modulators of dimethylarginine dimethylaminohydrolase (DDAH): a focus on selectivity over arginase
J. Enzyme Inhib. Med. Chem.
27
24-28
2012
Homo sapiens
brenda
Davids, M.; Richir, M.C.; Visser, M.; Ellger, B.; van den Berghe, G.; van Leeuwen, P.A.; Teerlink, T.
Role of dimethylarginine dimethylaminohydrolase activity in regulation of tissue and plasma concentrations of asymmetric dimethylarginine in an animal model of prolonged critical illness
Metab. Clin. Exp.
61
482-490
2012
Oryctolagus cuniculus
brenda
Ghebremariam, Y.T.; Erlanson, D.A.; Cooke, J.P.
A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide
J. Pharmacol. Exp. Ther.
348
69-76
2014
Homo sapiens (O94760), Homo sapiens
brenda
Sydow, K.; Schmitz, C.; von Leitner, E.C.; von Leitner, R.; Klinke, A.; Atzler, D.; Krebs, C.; Wieboldt, H.; Ehmke, H.; Schwedhelm, E.; Meinertz, T.; Blankenberg, S.; Boeger, R.H.; Magnus, T.; Baldus, S.; Wenzel, U.
Dimethylarginine dimethylaminohydrolase1 is an organ-specific mediator of end organ damage in a murine model of hypertension
PLoS ONE
7
e48150
2012
Homo sapiens (O94760)
brenda
Lambden, S.; Kelly, P.; Ahmetaj-Shala, B.; Wang, Z.; Lee, B.; Nandi, M.; Torondel, B.; Delahaye, M.; Dowsett, L.; Piper, S.; Tomlinson, J.; Caplin, B.; Colman, L.; Boruc, O.; Slaviero, A.; Zhao, L.; Oliver, E.; Khadayate, S.; Singer, M.; Arrigoni, F.; Leiper, J.
Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis
Arterioscler. Thromb. Vasc. Biol.
35
1382-1392
2015
Mus musculus (Q99LD8)
brenda
Yuan, Q.; Hu, C.P.; Gong, Z.C.; Bai, Y.P.; Liu, S.Y.; Li, Y.J.; Jiang, J.L.
Accelerated onset of senescence of endothelial progenitor cells in patients with type 2 diabetes mellitus role of dimethylarginine dimethylaminohydrolase 2 and asymmetric dimethylarginine
Biochem. Biophys. Res. Commun.
458
869-876
2015
Homo sapiens (O95865), Homo sapiens
brenda
Dowsett, L.; Piper, S.; Slaviero, A.; Dufton, N.; Wang, Z.; Boruc, O.; Delahaye, M.; Colman, L.; Kalk, E.; Tomlinson, J.; Birdsey, G.; Randi, A.M.; Leiper, J.
Endothelial dimethylarginine dimethylaminohydrolase 1 is an important regulator of angiogenesis but does not regulate vascular reactivity or hemodynamic homeostasis
Circulation
131
2217-2225
2015
Mus musculus (Q9CWS0), Mus musculus
brenda
Lundgren, B.; Bailey, F.; Moley, G.; Nomura, C.
DdaR (PA1196) regulates expression of dimethylarginine dimethylaminohydrolase for the metabolism of methylarginines in Pseudomonas aeruginosa PAO1
J. Bacteriol.
199
e00001-17
2017
Pseudomonas aeruginosa (Q9I4E3), Pseudomonas aeruginosa
brenda
Chertow, J.H.; Alkaitis, M.S.; Nardone, G.; Ikeda, A.K.; Cunnington, A.J.; Okebe, J.; Ebonyi, A.O.; Njie, M.; Correa, S.; Jayasooriya, S.; Casals-Pascual, C.; Billker, O.; Conway, D.J.; Walther, M.; Ackerman, H.
Plasmodium infection is associated with impaired hepatic dimethylarginine dimethylaminohydrolase activity and disruption of nitric oxide synthase inhibitor/substrate homeostasis
PLoS Pathog.
11
e1005119
2015
Homo sapiens (O94760), Homo sapiens, Mus musculus (Q9CWS0), Mus musculus
brenda
Shiozawa, T.; Iyama, S.; Toshima, S.; Sakata, A.; Usui, S.; Minami, Y.; Sato, Y.; Hizawa, N.; Noguchi, M.
Dimethylarginine dimethylaminohydrolase 2 promotes tumor angiogenesis in lung adenocarcinoma
Virchows Arch.
468
179-190
2016
Homo sapiens (O95865), Homo sapiens
brenda