Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2R)-4-(2'-ethyl[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-(2'-fluoro[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
-
(2R)-4-(3'-chloro[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-(3-fluoro-2-oxo-4-phenylpyridin-1(2H)-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-(4'-cyano[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-(4'-fluoro[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-(4-cyclohexyl-2-oxopyridin-1(2H)-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-(4-tert-butyl-2-oxopyridin-1(2H)-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-(5-fluoro-2-oxo-4-phenylpyridin-1(2H)-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
(2R)-4-[3-(2,3-difluorophenyl)-1,2-oxazol-5-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[3-(2-fluoro-3-methoxyphenyl)-1,2-oxazol-5-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[3-(2-fluoro-4-methoxyphenyl)-1,2-oxazol-5-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4'-(3-aminopropoxy)[1,1'-biphenyl]-4-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4'-(3-carbamimidamidopropoxy)[1,1'-biphenyl]-4-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4'-(aminomethyl)[1,1'-biphenyl]-4-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(2,3-dichlorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(2,5-difluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(2,6-difluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(2-chloro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(2-fluoro-3-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
-
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
(2R)-4-[4-(2-fluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(2H-1,3-benzodioxol-5-yl)phenyl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(3,4-dichlorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(3,4-difluorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(3,5-difluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(3,5-dimethylphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(3-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(3-fluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(4-chloro-2,3-difluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(4-chloro-2-fluorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(4-chloro-2-fluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(4-chloro-3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(4-fluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(benzyloxy)phenyl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(cyclohex-1-en-1-yl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(cyclopentyloxy)phenyl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[5-(2,3-dichlorophenyl)-1,2-oxazol-3-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[5-(2-fluoro-4-methoxyphenyl)-1,2-oxazol-3-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[5-(2-fluorophenyl)-1,2-oxazol-3-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[5-(3-fluorophenyl)-1,2-oxazol-3-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(1-phenyl-1H-1,2,3-triazol-4-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(1-phenyl-1H-pyrazol-4-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2'-oxo[2,4'-bipyridin]-1'(2'H)-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyrimidin-1(2H)-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo[4,4'-bipyridin]-1(2H)-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(3-phenyl-1,2-oxazol-5-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(4-oxo-7-phenylquinazolin-3(4H)-yl)butanamide
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(4-phenyl-1H-1,2,3-triazol-1-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(4-phenyl-1H-pyrazol-1-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(5-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(5-phenyl-1,2-oxazol-3-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(5-phenylpyridin-2-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(6-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(6-oxo-4-phenylpyrimidin-1(6H)-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(6-phenylpyridin-3-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-(2,3,4-trifluorophenyl)pyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-(2-phenylethyl)pyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-(phenylethynyl)pyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[(E)-2-phenylethenyl]pyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[4-(1,3-thiazol-2-yl)phenyl]pyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[4-(2H-1,2,3-triazol-2-yl)phenyl]pyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[4-(pyridin-2-yl)phenyl]pyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[4-(pyridin-4-yl)phenyl]pyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[3'-(1H-pyrazol-1-yl)[1,1'-biphenyl]-4-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[3'-(propan-2-yl)[1,1'-biphenyl]-4-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[3-(4-methylphenyl)-1,2-oxazol-5-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-(4-methylphenyl)-1H-1,2,3-triazol-1-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-(naphthalen-2-yl)-2-oxopyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-(phenylsulfanyl)phenyl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-(pyridin-3-yl)phenyl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-[(pyridin-4-yl)oxy]phenyl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-[4-(1,2-oxazol-3-yl)phenyl]-2-oxopyridin-1(2H)-yl]butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-4-(2'-methoxy[1,1'-biphenyl]-4-yl)-2-methylbutanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-4-(6-methoxy-2'-oxo[3,4'-bipyridin]-1'(2'H)-yl)-2-methylbutanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-(2-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-(3-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-[4-(2-methoxypyrimidin-5-yl)phenyl]-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-[4-(5-methoxypyrimidin-2-yl)phenyl]-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
-
(2R)-N-hydroxy-2-[(naphthalene-2-sulfonyl)methyl]-3-(naphthalen-2-yl)propanamide
-
-
(2R)-N-hydroxy-3-naphthalen-2-yl-2-[(naphthalen-2-ylsulfonyl)amino]propanamide
potent inhibitor, shows antibacterial activity against a wide range of Gram-negative pathogens, binding mode
(2R)-N-hydroxy-4-(2-hydroxy-6-phenylpyridin-3-yl)-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-N-hydroxy-4-[4'-(hydroxyacetyl)[1,1'-biphenyl]-4-yl]-2-(methanesulfonyl)-2-methylbutanamide
-
(2R,3R,4S,5S)-N,3,4-trihydroxy-5-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]oxolane-2-carboxamide
-
-
(2S)-N,3-dihydroxy-2-[(1S)-2-hydroxy-1-[4-(phenylethynyl)phenyl]ethoxy]propanamide
-
(2S)-N,3-dihydroxy-2-[(1S)-2-hydroxy-1-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]ethoxy]propanamide
-
(2S)-N1-hydroxy-2-[4-(phenylethynyl)benzamido]butanediamide
-
(2S,3R)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1,2-oxazol-5-yl)propanamide
-
(2S,3R)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1,3-oxazol-2-yl)propanamide
-
(2S,3R)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylbutanamide
-
(2S,3R)-2-[5-([1,1'-biphenyl]-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]-N,3-dihydroxybutanamide
-
(2S,3R)-2-[5-[([1,1'-biphenyl]-3-yl)ethynyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl]-N,3-dihydroxybutanamide
-
(2S,3R)-2-[5-[([1,1'-biphenyl]-4-yl)ethynyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl]-N,3-dihydroxybutanamide
-
(2S,3R)-N,3-dihydroxy-2-(1-oxo-5-phenyl-1,3-dihydro-2H-isoindol-2-yl)butanamide
-
(2S,3R)-N,3-dihydroxy-2-[1-oxo-5-(phenylethynyl)-1,3-dihydro-2H-isoindol-2-yl]butanamide
-
(2S,3R)-N,3-dihydroxy-2-[1-oxo-5-[4-(phenylethynyl)phenyl]-1,3-dihydro-2H-isoindol-2-yl]butanamide
-
(2S,3R)-N,3-dihydroxy-2-[1-oxo-6-(phenylethynyl)-1,3-dihydro-2H-isoindol-2-yl]butanamide
-
(2S,3R)-N,3-dihydroxy-2-[3-oxo-6-(phenylethynyl)-1,3-dihydro-2H-indazol-2-yl]butanamide
-
(2S,3R,4S,5R)-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-N,3,4-trihydroxyoxolane-2-carboxamide
-
-
(2S,3R,4S,5R)-5-(1-hexyl-1H-1,2,3-triazol-4-yl)-N,3,4-trihydroxyoxolane-2-carboxamide
-
-
(2S,3R,4S,5R)-5-[1-[(4-fluorophenyl)methyl]-1H-1,2,3-triazol-4-yl]-N,3,4-trihydroxyoxolane-2-carboxamide
-
-
(2S,3R,4S,5R)-N,3,4-trihydroxy-5-(1-phenyl-1H-1,2,3-triazol-4-yl)oxolane-2-carboxamide
-
-
(2S,3R,4S,5R)-N,3,4-trihydroxy-5-(1-[[4-(trifluoromethyl)phenyl]methyl]-1H-1,2,3-triazol-4-yl)oxolane-2-carboxamide
-
-
(2S,3R,4S,5R)-N,3,4-trihydroxy-5-(2-(4-[2-(4-methoxyphenyl)ethynyl]phenyl)ethynyl)tetrahydrofuran-2-carboxamide
-
-
(2S,3R,4S,5R)-N,3,4-trihydroxy-5-(octa-1,3-diyn-1-yl)tetrahydrofuran-2-carboxamide
-
-
(2S,3R,4S,5R)-N,3,4-trihydroxy-5-(phenylbuta-1,3-diyn-1-yl)tetrahydrofuran-2-carboxamide
-
-
(2S,3R,4S,5R)-N,3,4-trihydroxy-5-([4-(phenylethynyl)phenyl]ethynyl)tetrahydrofuran-2-carboxamide
-
-
(2S,3R,4S,5R)-N,3,4-trihydroxy-5-[1-(2-phenylethyl)-1H-1,2,3-triazol-4-yl]oxolane-2-carboxamide
-
-
(2S,3R,4S,5R)-N,3,4-trihydroxy-5-[1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl]oxolane-2-carboxamide
-
-
(2S,3R,4S,5R)-N,3,4-trihydroxy-5-[2-(4-(2-[4-(trifluoromethyl)phenyl]ethynyl)phenyl)ethynyl]tetrahydrofuran-2-carboxamide
-
-
(2S,3R,4S,5S)-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-N,3,4-trihydroxytetrahydrofuran-2-carboxamide
-
-
(2S,3R,4S,5S)-5-[1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl]-N,3,4-trihydroxytetrahydrofuran-2-carboxamide
-
-
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-((4-[(4-methoxyphenyl)ethynyl]phenyl)ethynyl)tetrahydrofuran-2-carboxamide
-
-
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-(1-phenethyl-1H-1,2,3-triazol-4-yl)tetrahydrofuran-2-carboxamide
-
-
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-(1-phenyl-1H-1,2,3-triazol-4-yl)tetrahydrofuran-2-carboxamide
-
-
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-(1-[4-(trifluoromethyl)benzyl]-1H-1,2,3-triazol-4-yl)tetrahydrofuran-2-carboxamide
-
-
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-(phenylbuta-1,3-diyn-1-yl)tetrahydrofuran-2-carboxamide
-
-
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-([4-(phenylethynyl)phenyl]ethynyl)tetrahydrofuran-2-carboxamide
-
-
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-[(4-([4-(trifluoromethyl)phenyl]ethynyl)phenyl)ethynyl]tetrahydrofuran-2-carboxamide
-
-
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-[1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl]tetrahydrofuran-2-carboxamide
-
-
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-[4-(4-phenylbuta-1,3-diyn-1-yl)phenyl]oxolane-2-carboxamide
-
-
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]oxolane-2-carboxamide
-
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-5-ethoxy-N,3-dihydroxy-2-methylpentanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2,4-dimethylpentanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1,2-oxazol-3-yl)propanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1-methyl-1H-1,2,3-triazol-5-yl)propanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1-methyl-1H-imidazol-2-yl)propanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1H-pyrazol-5-yl)propanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(5-methyl-1,2-oxazol-3-yl)propanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(pyridin-2-yl)propanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(pyridin-3-yl)propanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-phenylpropanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylbutanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylheptanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylpentanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-3-(1H-imidazol-5-yl)-2-methylpropanamide
-
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-3-[5-(hydroxymethyl)-1,2-oxazol-3-yl]-2-methylpropanamide
-
(2S,4S,5S)-N,4-dihydroxy-5-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]oxolane-2-carboxamide
-
-
(3-(4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)methanethiol
-
-
(3R,5R)-3-hydroxy-5-(2-(hydroxyamino)-2-oxoethyl)-2-(hydroxymethyl)tetrahydro-2H-pyran-4-yl tetradecanoate
(3S,4R)-N,3,4-trihydroxy-1-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzoyl]-L-prolinamide
-
-
(4R)-2-(1-benzothiophen-2-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 10% inhibition
(4R)-2-(1-butyl-1H-indazol-3-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(2,4-dichlorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 32% inhibition
(4R)-2-(2-butyl-2H-indazol-3-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(2H-1,3-benzodioxol-5-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 46% inhibition
(4R)-2-(3,4-dichlorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 68% inhibition
(4R)-2-(3,4-difluorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 60% inhibition
(4R)-2-(3,4-dimethoxy-5-propylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
(4R)-2-(3,5-dichlorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 61% inhibition
(4R)-2-(3,5-difluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 85% inhibition
(4R)-2-(3,5-difluorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 37% inhibition
(4R)-2-(3,5-dimethoxy-4-methylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 37% inhibition
(4R)-2-(3,5-dimethoxyphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 67% inhibition
(4R)-2-(3-bromo-4-fluorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
(4R)-2-(3-bromo-5-fluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(3-chloro-4-fluorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 69% inhibition
(4R)-2-(3-chloro-5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(3-cyanophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 54% inhibition
(4R)-2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(3-fluoro-4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(3-fluoro-4-[[3-(trifluoromethyl)phenyl]methoxy]phenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(4-acetylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(4-bromophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(4-butylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
(4R)-2-(4-chloro-3-nitrophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 70% inhibition
(4R)-2-(4-ethoxy-3-oxobutyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 18% inhibition
(4R)-2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
(4R)-2-(4-fluoro-3-nitrophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 57% inhibition
(4R)-2-(4-fluoro-3-propylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(4-fluorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(4-tert-butylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 58% inhibition
(4R)-2-(5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(adamantan-1-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 71% inhibition
(4R)-2-([1,1'-biphenyl]-4-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 69% inhibition
(4R)-2-benzyl-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 34% inhibition
(4R)-2-cyclopentyl-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 7% inhibition
(4R)-2-dodecyl-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 60% inhibition
(4R)-2-[(4-chlorophenyl)methyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 12% inhibition
(4R)-2-[(E)-2-(2-chlorophenyl)ethenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 36% inhibition
(4R)-2-[(E)-2-(4-fluorophenyl)ethenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 50% inhibition
(4R)-2-[2-(ethylsulfanyl)pyridin-3-yl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 18% inhibition
(4R)-2-[3,5-bis(trifluoromethyl)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 57% inhibition
(4R)-2-[3-(benzyloxy)-4-methoxyphenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 8% inhibition
(4R)-2-[3-chloro-4-(trifluoromethoxy)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-[3-fluoro-4-(trifluoromethyl)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 55% inhibition
(4R)-2-[3-fluoro-4-[(prop-2-en-1-yl)oxy]phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-[3-fluoro-5-(trifluoromethyl)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 12% inhibition
-
(4R)-2-[4-(benzyloxy)-3,5-dimethylphenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 61% inhibition
(4R)-2-[4-(benzyloxy)-3-methoxyphenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 13% inhibition
(4R)-2-[4-(dimethylamino)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-[4-(hexyloxy)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 86% inhibition
(4R)-2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 77% inhibition
(4R)-2-[4-[(3-fluorophenyl)methoxy]-3-(trifluoromethoxy)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-[4-[(but-3-en-1-yl)oxy]-3-(trifluoromethoxy)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-[4-[(but-3-en-1-yl)oxy]phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-[4-[(but-3-en-1-yl)oxy]phenyl]-N-hydroxy-4,5-dihydro-1,3-thiazole-4-carboxamide
-
(4R)-2-[5-fluoro-4-methoxy-2-methyl-3-(prop-2-en-1-yl)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N,4-dihydroxy-1-[4-(phenylethynyl)benzoyl]-L-prolinamide
-
-
(4R)-N,4-dihydroxy-1-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzoyl]-L-prolinamide
-
-
(4R)-N,4-dihydroxy-1-[4-[(4-pentylphenyl)ethynyl]benzoyl]-L-prolinamide
-
-
(4R)-N,4-dihydroxy-1-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]methyl]-L-prolinamide
-
-
(4R)-N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-(2,3,4-trifluorophenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 25% inhibition
(4R)-N-hydroxy-2-(2,3,5-trifluoro-4-methoxyphenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 35% inhibition
(4R)-N-hydroxy-2-(2-phenylcyclopropyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 31% inhibition
(4R)-N-hydroxy-2-(2-phenylethyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 32% inhibition
(4R)-N-hydroxy-2-(3,4,5-triethoxyphenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 86% inhibition
(4R)-N-hydroxy-2-(3,4,5-trifluorophenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 54% inhibition
(4R)-N-hydroxy-2-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 72% inhibition
(4R)-N-hydroxy-2-(3-methoxyphenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 44% inhibition
(4R)-N-hydroxy-2-(4'-propyl[1,1'-biphenyl]-4-yl)-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-(4-iodophenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-(4-methoxy-3,5-dimethylphenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 71% inhibition
(4R)-N-hydroxy-2-(4-methoxy-3-nitrophenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 78% inhibition
(4R)-N-hydroxy-2-(4-methoxyphenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
(4R)-N-hydroxy-2-(4-methyl-3-nitrophenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 79% inhibition
(4R)-N-hydroxy-2-(4-methylphenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-(4-methylphenyl)-4,5-dihydro-1,3-thiazole-4-carboxamide
-
(4R)-N-hydroxy-2-(4-nitrophenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
(4R)-N-hydroxy-2-(9-oxo-9H-fluoren-1-yl)-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 1% inhibition
(4R)-N-hydroxy-2-(naphthalen-1-yl)-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 19% inhibition
(4R)-N-hydroxy-2-(naphthalen-2-yl)-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 35% inhibition
(4R)-N-hydroxy-2-(thiophen-2-yl)-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 19% inhibition
(4R)-N-hydroxy-2-tricyclo[3.3.1.1-3,7]dec-1-yl-4,5-dihydro-1,3-oxazole-4-carboxamide
-
1 microg/ml, high inhibitory activity
(4R)-N-hydroxy-2-[(1S,4R)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptan-1-yl]-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 8% inhibition
(4R)-N-hydroxy-2-[(4-methoxyphenyl)methyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 10% inhibition
(4R)-N-hydroxy-2-[(E)-2-(4-methoxyphenyl)ethenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 48% inhibition
(4R)-N-hydroxy-2-[(E)-2-(4-nitrophenyl)ethenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 1% inhibition
(4R)-N-hydroxy-2-[(E)-2-phenylethenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 39% inhibition
(4R)-N-hydroxy-2-[(E)-2-[3-(trifluoromethyl)phenyl]ethenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 32% inhibition
(4R)-N-hydroxy-2-[(thiophen-2-yl)methyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 17% inhibition
(4R)-N-hydroxy-2-[3-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 64% inhibition
(4R)-N-hydroxy-2-[3-(trifluoromethyl)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 59% inhibition; 0.001 mg/ml, 65% inhibition
(4R)-N-hydroxy-2-[4-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 79% inhibition
(4R)-N-hydroxy-2-[4-(trifluoromethyl)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-[4-methoxy-3,5-bis(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-thiazole-4-carboxamide
-
(4R)-N-hydroxy-2-[4-methoxy-3-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-[4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-[4-[(3-methylbut-2-en-1-yl)oxy]-3-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-[4-[(3-nitrophenoxy)methyl]phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-[4-[(3-nitrophenyl)methoxy]phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-[4-[(E)-phenyldiazenyl]phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 71% inhibition
(4R)-N-hydroxy-2-[4-[(prop-2-en-1-yl)oxy]-3-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-[4-[(prop-2-en-1-yl)oxy]-3-(trifluoromethyl)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-[6-(trifluoromethyl)pyridin-3-yl]-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4S)-1-(4-[[4-(dimethylamino)phenyl]ethynyl]benzoyl)-N,4-dihydroxy-L-prolinamide
-
-
(4S)-4-fluoro-N-hydroxy-1-[4-(phenylethynyl)benzoyl]-L-prolinamide
-
-
(4S)-N,4-dihydroxy-1-[4-([4-[(4-hydroxypiperidin-1-yl)methyl]phenyl]ethynyl)benzoyl]-L-prolinamide
-
-
(4S)-N,4-dihydroxy-1-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzoyl]-L-prolinamide
-
-
(4S)-N,4-dihydroxy-1-[4-([4-[(piperidin-1-yl)methyl]phenyl]ethynyl)benzoyl]-L-prolinamide
-
-
(4S)-N,4-dihydroxy-1-[4-([4-[(thiomorpholin-4-yl)methyl]phenyl]ethynyl)benzoyl]-L-prolinamide
-
-
(R)-(hydroxyamino)((R)-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrothiazol-4-yl)methanol
-
-
(R)-2-(1-butyl-1H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-2-(2-bromophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, nearly complete loss of activity
(R)-2-(2-butyl-2H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-2-(3,4-dichlorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, exellent biological activity
(R)-2-(3,4-difluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, exellent biological activity
(R)-2-(3,4-dimethoxy-5-propylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml
(R)-2-(3,5-dichlorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, moderate activity
(R)-2-(3,5-difluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, good activity
(R)-2-(3,5-difluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, moderate activity
(R)-2-(3,5-dimethoxyphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, 67% inhibition
(R)-2-(3-(dichloromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml
(R)-2-(3-bromo-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, exellent biological activity
(R)-2-(3-chloro-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, exellent biological activity
(R)-2-(3-cyanophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml
(R)-2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-2-(3-fluoro-4-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, slight lower inhibitory activity than (R)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
(R)-2-(3-fluoro-5-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, good activity
(R)-2-(4-(3-fluorobenzyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-2-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-2-(4-(dimethylamino)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-2-(4-(hexyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, 86% inhibition
(R)-2-(4-(hydroxycarbamoyl)-4,5-dihydrooxazol-2-yl)benzyl benzoate
-
1 microg/ml, nearly complete loss of activity
(R)-2-(4-bromophenylsulfonamido)-3-(5,8-dihydronaphthalen-2-yl)-N-hydroxypropanamide
-
-
(R)-2-(4-chloro-3-nitrophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml
(R)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
(R)-2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-2-(4-fluoro-3-nitrophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml
(R)-2-(4-tert-butylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, 58% inhibition
(R)-2-(biphenyl-4-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, 69% inhibition
(R)-2-decyl-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, high inhibitory activity
(R)-3-(5,8-dihydronaphthalen-2-yl)-N-hydroxy-2-(naphthalene-2-sulfonamido)propanamide
(R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-2-isopropyl-4-oxobutanamide
-
-
(R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-2-methyl-4-oxobutanamide
-
-
(R)-N-(1-(2-(3,4-dimethoxy-5-propylphenyl)-4,5-dihydrooxazol-4-yl)vinyl)hydroxylamine
-
-
(R)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-1H-indazole-3-carboxamide
-
-
(R)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methoxy-3-propyl-5-(trifluoromethoxy)benzamide
-
-
(R)-N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-N-hydroxy-2-(2,3,5-trifluoro-4-methoxyphenyl)-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, good activity
(R)-N-hydroxy-2-(2-methylprop-1-enyl)-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, moderate activity
(R)-N-hydroxy-2-(3,4,5-triethoxyphenyl)-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, 72% inhibition
(R)-N-hydroxy-2-(3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, exellent inhibitory activity
(R)-N-hydroxy-2-(3-methoxyphenyl)-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, 44% inhibition
(R)-N-hydroxy-2-(4-((3-nitrophenoxy)methyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-N-hydroxy-2-(4-(3-nitrobenzyloxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-N-hydroxy-2-(4-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml
(R)-N-hydroxy-2-(4-hydroxyphenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-N-hydroxy-2-(4-methoxy-3,5-dimethylphenyl)-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, 71% inhibition
(R)-N-hydroxy-2-(4-methoxy-3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-N-hydroxy-2-(4-methoxy-3-nitrophenyl)-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml
(R)-N-hydroxy-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-N-hydroxy-2-(4-methoxyphenyl)-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml
(R)-N-hydroxy-2-(4-methyl-3-nitrophenyl)-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml
(R)-N-hydroxy-2-(4-nitrophenyl)-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml
(R)-N-hydroxy-2-p-tolyl-4,5-dihydrothiazole-4-carboxamide
-
-
(R,E)-2-(2-chlorostyryl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, moderate activity
(R,E)-N-hydroxy-2-(3-(trifluoromethyl)styryl)-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, moderate activity
(R,E)-N-hydroxy-2-(4-nitrostyryl)-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, moderate activity
(R,E)-N-hydroxy-2-styryl-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, moderate activity
(S)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-4,5-dihydroisoxazole-5-carboxamide
-
-
(S)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-5-methyl-4,5-dihydroisoxazole-5-carboxamide
-
-
(S)-3-(4-methoxyphenyl)-4,5-dihydro-isoxazole-5-carboxylic acid hydroxyamide
-
-
(S)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-2-methyl-4-oxobutanamide
-
-
(S)-N-(1-(2-(3,4-dimethoxy-5-propylphenyl)-4,5-dihydrooxazol-4-yl)vinyl)hydroxylamine
(S)-N-hydroxy-1-(4-[[4-(morpholinomethyl)phenyl]ethynyl]benzyl)pyrrolidine-2-carboxamide
-
highly active antibacterial compound
1,5-anhydro-2,3-dideoxy-2-[2-(hydroxyamino)-2-oxoethyl]-D-ribo-hexitol
-
1,5-anhydro-2,4-dideoxy-2-[2-(hydroxyamino)-2-oxoethyl]-3-O-tetradecanoyl-D-xylo-hexitol
0.001 mg/ml, 18% inhibition
1,5-anhydro-2,6-dideoxy-2-[2-(hydroxyamino)-2-oxoethyl]-3-O-tetradecanoyl-D-glucitol
0.001 mg/ml, 15% inhibition
1,5-anhydro-2-C-(carboxymethyl-N-hydroxyamide)-2-deoxy-3-O-myristoyl-D-glucitol
1,5-anhydro-2-deoxy-2-[(2Z)-2-hydroxy-2-(hydroxyimino)ethyl]-3-O-tetradecanoyl-L-mannitol
-
-
1,5-anhydro-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-3-O-tetradecanoyl-D-glucitol
1,5-anhydro-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-3-O-tetradecyl-D-glucitol
0.001 mg/ml, 13% inhibition
1,5-anhydro-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-3-O-[(3S)-3-hydroxyhexadecanoyl]-D-glucitol
1,5-anhydro-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-4-O-methyl-3-O-tetradecanoyl-D-glucitol
0.001 mg/ml, 30% inhibition
1,5-anhydro-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-6-O-methyl-3-O-tetradecanoyl-D-glucitol
0.001 mg/ml, 3% inhibition
1,5-anhydro-2-deoxy-3-O-hexadecanoyl-2-[2-(hydroxyamino)-2-oxoethyl]-D-glucitol
0.001 mg/ml, 11% inhibition
1,5-anhydro-2-deoxy-3-O-hexanoyl-2-[2-(hydroxyamino)-2-oxoethyl]-D-glucitol
-
1,5-anhydro-2-deoxy-3-O-hexanoyl-2-[[hydroxy(methyl)phosphoryl]methyl]-D-glucitol
1,5-anhydro-3-O-benzoyl-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-D-glucitol
0.001 mg/ml, 53% inhibition
1-benzyl-N-hydroxy-4-[4-(phenylethynyl)benzamido]piperidine-4-carboxamide
-
1-hydroxy-4-[4-[(3R)-4-(hydroxyamino)-3-(methanesulfonyl)-3-methyl-4-oxobutyl]phenoxy]pyridin-1-ium
-
1-[4-([4-[(1,1-dioxo-1lambda6-thiomorpholin-4-yl)methyl]phenyl]ethynyl)benzoyl]-N-hydroxy-L-prolinamide
-
-
2,3-dihydroxy-benzaldehyde O-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-oxime
-
weak inhibitor
2,4-dihydroxy-benzaldehyde O-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-oxime
-
-
2-(1-butyl-1H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(2-butyl-2H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3,4-bis(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)-N-hydroxyacetamide
-
-
2-(3-allyl-5-fluoro-4-methoxy-2-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-bromo-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-bromo-5-fluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-chloro-4-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-chloro-5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-fluoro-4-(2-(trifluoromethyl)benzyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-fluoro-4-(3-(trifluoromethyl)benzyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-fluoro-4-(3-methylbenzyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(3-fluoro-5-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-(3-fluorobenzyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-(allyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-(allyloxy)-3-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-(but-3-enyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrothiazole-4-carboxamide
-
-
2-(4-(dimethylamino)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-(heptyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-acetamidophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-acetylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-bromophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-butylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
-
-
2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-fluoro-3-propylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-fluorophenyl)-N-hydroxy-4,5-dihydro-1,3-thiazole-4-carboxamide
-
2-(4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(4-fluorophenyl)-N-hydroxy-4,5-dihydrothiazole-4-carboxamide
-
-
2-(5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
2-(5-fluoro-1H-indol-2-yl)-N-hydroxy-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
2-mercapto-1-[3-(4-methoxyphenyl)-4,5-dihydro-isoxazol-5-yl]ethanone
-
racemate
2-thioacetyl-1-[3-(4-methoxyphenyl)-4,5-dihydro-isoxazol-5-yl]ethanone
-
racemate
2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylpropanamide
-
2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-hydroxy-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
-
2-[[([1,1'-biphenyl]-4-yl)oxy]methyl]-N,3-dihydroxy-2-methylpropanamide
-
2-[[4-(diethylamino)-2-hydroxyphenyl]carbonyl]benzoic acid
-
compound shows good activity against Escherichia coli and Pseudomonas aeruginosa
3,4,5-trihydroxy-benzaldehyde O-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-oxime
-
weak inhibitor, contains a 5 position hydroxyl and exhibits greatly reduced inhibitory potency
3,4-dihydroxy-benzaldehyde O-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-oxime
-
50 microM, 49% inhibition
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide
-
-
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxylic acid
-
-
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-4,5-dihydroisoxazole-5-carboxamide
-
-
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-5-methyl-4,5-dihydroisoxazole-5-carboxamide
-
-
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-5-propyl-4,5-dihydroisoxazole-5-carboxamide
-
-
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-N-methyl-4,5-dihydroisoxazole-5-carboxamide
-
-
3-(4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl(methyl)phosphinic acid
-
-
3-([1,1'-biphenyl]-4-sulfonyl)-N-hydroxy-2-(methanesulfonyl)-2-methylpropanamide
-
3-ethoxy-4-fluoro-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
-
-
3-ethoxy-4-fluoro-N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]benzamide
-
3-[([1,1'-biphenyl]-4-yl)oxy]-N-hydroxy-2-(methanesulfonyl)-2-methylpropanamide
-
3-[([1,1'-biphenyl]-4-yl)sulfanyl]-N-hydroxy-2-(methanesulfonyl)-2-methylpropanamide
-
4'-ethyl-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl][1,1'-biphenyl]-4-carboxamide
-
4'-[(3R)-4-(hydroxyamino)-3-(methanesulfonyl)-3-methyl-4-oxobutyl][1,1'-biphenyl]-3-carboxamide
-
4'-[(3R)-4-(hydroxyamino)-3-(methanesulfonyl)-3-methyl-4-oxobutyl][1,1'-biphenyl]-4-carboxylic acid
-
4-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-oxobutanoic acid
-
-
4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-4-oxobutanamide
-
-
4-(4-[[4-(cyanomethyl)phenyl]ethynyl]phenyl)-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]piperazine-1-carboxamide
-
4-(allyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-3-(trifluoromethoxy)benzamide
-
-
4-(but-3-enyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
-
-
4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(hydroxymethyl)-2-methylbutanamide
-
4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)butanamide
-
4-([1,1'-biphenyl]-4-yl)-N-[(2S)-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]piperazine-1-carboxamide
-
4-([1,1'-biphenyl]-4-yl)-N-[(2S)-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]piperidine-1-carboxamide
-
4-([1,1'-biphenyl]-4-yl)-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]piperazine-1-carboxamide
-
4-([1,1'-biphenyl]-4-yl)-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]piperidine-1-carboxamide
-
4-([4'-[(3R)-4-(hydroxyamino)-3-(methanesulfonyl)-3-methyl-4-oxobutyl][1,1'-biphenyl]-4-yl]oxy)butanoic acid
-
4-([4-[(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]methyl]phenyl)ethynyl]phenoxy]methyl)-N-hydroxyoxane-4-carboxamide
-
4-([[4-(4-chlorophenoxy)phenyl]sulfanyl]methyl)-N-hydroxyoxane-4-carboxamide
-
4-({4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]phenoxy}methyl)-N-hydroxyoxane-4-carboxamide
4-({4-[(4-{[(2R,6S)-2,6-dimethylmorpholin-4-yl]methyl}phenyl)ethynyl]phenoxy}methyl)-N-hydroxyoxane-4-carboxamide
4-({[4-(4-chlorophenoxy)phenyl]sulfanyl}methyl)-N-hydroxyoxane-4-carboxamide
4-fluoro-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
-
-
4-[(4-[[4-([2-[(dimethylamino)methyl]morpholin-4-yl]methyl)phenyl]ethynyl]phenoxy)methyl]-N-hydroxyoxane-4-carboxamide
-
4-[(4-{2-[(dimethylamino)methyl]morpholin-4-yl}phenoxy)methyl]-N-hydroxyoxane-4-carboxamide
4-[(4-{[4-({2-[(dimethylamino)methyl]morpholin-4-yl}methyl)phenyl]ethynyl}phenoxy)methyl]-N-hydroxyoxane-4-carboxamide
4-[(but-3-en-1-yl)oxy]-N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]benzamide
-
4-[4-[(4-aminophenyl)ethynyl]phenyl]-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]piperazine-1-carboxamide
-
4-[4-[(4-chlorophenyl)ethynyl]phenyl]-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]piperazine-1-carboxamide
-
4-[4-[(4-fluorophenyl)ethynyl]phenyl]-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]piperazine-1-carboxamide
-
4-[[([1,1'-biphenyl]-4-yl)oxy]methyl]-N-hydroxyoxane-4-carboxamide
-
4-[[4-(benzyloxy)phenoxy]methyl]-N-hydroxyoxane-4-carboxamide
-
4-[[4-([4-[(4-acetylpiperazin-1-yl)methyl]phenyl]ethynyl)phenoxy]methyl]-N-hydroxyoxane-4-carboxamide
-
4-{[4-(4-acetylpiperazin-1-yl)phenoxy]methyl}-N-hydroxyoxane-4-carboxamide
4-{[4-({4-[(4-acetylpiperazin-1-yl)methyl]phenyl}ethynyl)phenoxy]methyl}-N-hydroxyoxane-4-carboxamide
5'-deoxy-5'-[2-([(E)-[(2,3,4-trihydroxyphenyl)methylidene]amino]oxy)acetamido]uridine
-
5'-O-[(E)-(2,3,4-trihydroxybenzylidene)amino]uridine
5'-O-[(E)-(3,4-dihydroxybenzylidene)amino]uridine
5'-O-[(E)-[(2,3,4-trihydroxyphenyl)methylidene]amino]uridine
-
5'-O-[(E)-[(3,4-dihydroxyphenyl)methylidene]amino]uridine
-
5-ethyl-5-(2-oxo-2-[4-[4-(phenylethynyl)phenyl]piperidin-1-yl]ethyl)imidazolidine-2,4-dione
-
5-methyl-5-(2-oxo-2-[4-[4-(phenylethynyl)phenyl]piperazin-1-yl]ethyl)imidazolidine-2,4-dione
-
5-methyl-5-(2-oxo-2-[4-[4-(phenylethynyl)phenyl]piperidin-1-yl]ethyl)imidazolidine-2,4-dione
-
6-(1H-benzimidazol-1-yl)-N-hydroxy-5-[4-([6-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl]ethynyl)phenyl]pyridine-3-carboxamide
crystal structure of inhibitor B bound to the enzyme
dipicolinic acid
-
0.02 mM, complete inhibition
N'-formyl-3-(4-methoxyphenyl)-4,5-dihydroisoxazole-5-carbohydrazide
-
-
N,4-dihydroxy-1-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}cyclohexane-1-carboxamide
N-(((2R,3R,4S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)-2-((Z)-2,3,4-trihydroxybenzylideneaminooxy)acetamide
-
-
N-((2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl)-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamide
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-1H-indazole-3-carboxamide
-
-
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-(trifluoromethoxy)benzamide
-
-
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methoxy-3-propyl-5-(trifluoromethoxy)benzamide
-
-
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methylbenzamide
-
-
N-ethylmaleimide
-
1 mM, complete inhibition
N-hydroxy-1,1-dioxo-4-[4-(phenylethynyl)benzamido]-1lambda6-thiane-4-carboxamide
-
N-hydroxy-1-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzoyl]-D-prolinamide
-
-
N-hydroxy-1-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzoyl]-L-prolinamide
-
-
N-hydroxy-1-[4-([4-[(thiomorpholin-4-yl)methyl]phenyl]ethynyl)benzoyl]-L-prolinamide
-
-
N-hydroxy-1-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]methyl]-L-prolinamide
-
-
N-hydroxy-1-[[4-([4-[(thiomorpholin-4-yl)methyl]phenyl]ethynyl)phenyl]methyl]-L-prolinamide
-
-
N-hydroxy-2-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(2-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(3-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(3-propyl-4,5-bis(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4'-propylbiphenyl-4-yl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4-((3-nitrophenoxy)methyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4-(3-methylbut-2-enyloxy)-3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4-(3-nitrobenzyloxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4-(trifluoromethoxy)phenyl)-4,5-dihydrothiazole-4-carboxamide
-
-
N-hydroxy-2-(4-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4-hydroxyphenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4-iodophenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4-methoxy-3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrothiazole-4-carboxamide
-
-
N-hydroxy-2-(4-nitrophenyl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydrothiazole-4-carboxamide
-
-
N-hydroxy-2-(6-(trifluoromethyl)pyridin-3-yl)-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-p-tolyl-4,5-dihydrooxazole-4-carboxamide
-
-
N-hydroxy-2-p-tolyl-4,5-dihydrothiazole-4-carboxamide
-
-
N-hydroxy-2-p-tolyl-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
-
-
N-hydroxy-2-[(1R)-2-hydroxy-1-[4-(phenylethynyl)phenyl]ethoxy]acetamide
-
N-hydroxy-2-[(1R)-2-hydroxy-1-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]ethoxy]acetamide
-
N-hydroxy-2-[(1S)-2-hydroxy-1-[4-(phenylethynyl)phenyl]ethoxy]acetamide
-
N-hydroxy-2-[(1S)-2-hydroxy-1-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]ethoxy]acetamide
-
N-hydroxy-2-[4-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-thiazole-4-carboxamide
-
N-hydroxy-2-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]methoxy]acetamide
-
N-hydroxy-4-([4-[(4-[[4-(propan-2-yl)piperazin-1-yl]methyl]phenyl)ethynyl]phenoxy]methyl)oxane-4-carboxamide
-
N-hydroxy-4-([[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]sulfanyl]methyl)oxane-4-carboxamide
-
N-hydroxy-4-({4-[(4-{[4-(propan-2-yl)piperazin-1-yl]methyl}phenyl)ethynyl]phenoxy}methyl)oxane-4-carboxamide
N-hydroxy-4-({4-[4-(propan-2-yl)piperazin-1-yl]phenoxy}methyl)oxane-4-carboxamide
N-hydroxy-4-({[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenyl]sulfanyl}methyl)oxane-4-carboxamide
N-hydroxy-4-methoxy-1-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenoxy]methyl]cyclohexane-1-carboxamide
-
N-hydroxy-4-methoxy-1-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}cyclohexane-1-carboxamide
N-hydroxy-4-[(4-phenoxyphenoxy)methyl]oxane-4-carboxamide
-
N-hydroxy-4-[(4-[[4-([4-[2-(1H-imidazol-1-yl)ethyl]piperazin-1-yl]methyl)phenyl]ethynyl]phenoxy)methyl]oxane-4-carboxamide
-
N-hydroxy-4-[(4-[[4-([4-[2-(morpholin-4-yl)-2-oxoethyl]piperazin-1-yl]methyl)phenyl]ethynyl]phenoxy)methyl]oxane-4-carboxamide
-
N-hydroxy-4-[(4-[[4-([4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl]methyl)phenyl]ethynyl]phenoxy)methyl]oxane-4-carboxamide
-
N-hydroxy-4-[(4-[[4-([[(4-methoxyphenyl)methyl]amino]methyl)phenyl]ethynyl]phenoxy)methyl]oxane-4-carboxamide
-
N-hydroxy-4-[(4-{4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl}phenoxy)methyl]oxane-4-carboxamide
N-hydroxy-4-[(4-{[4-({4-[2-(1H-imidazol-1-yl)ethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
N-hydroxy-4-[(4-{[4-({4-[2-(morpholin-4-yl)-2-oxoethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
N-hydroxy-4-[(4-{[4-({4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
N-hydroxy-4-[(4-{[4-({[(4-methoxyphenyl)methyl]amino}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
N-hydroxy-4-[4-(phenylethynyl)benzamido]oxane-4-carboxamide
-
N-hydroxy-4-[4-(phenylethynyl)benzamido]piperidine-4-carboxamide
-
N-hydroxy-4-[4-(phenylethynyl)benzamido]thiane-4-carboxamide
-
N-hydroxy-4-[[4-(4-phenylbuta-1,3-diyn-1-yl)phenoxy]methyl]oxane-4-carboxamide
-
N-hydroxy-4-[[4-(5-hydroxy-5-methylhexa-1,3-diyn-1-yl)phenoxy]methyl]oxane-4-carboxamide
-
N-hydroxy-4-[[4-([4-[(4-methylpiperazin-1-yl)methyl]phenyl]ethynyl)phenoxy]methyl]oxane-4-carboxamide
-
N-hydroxy-4-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzene-1-sulfinyl]methyl]oxane-4-carboxamide
-
N-hydroxy-4-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenoxy]methyl]oxane-4-carboxamide
-
N-hydroxy-4-{[4-({4-[(4-methylpiperazin-1-yl)methyl]phenyl}ethynyl)phenoxy]methyl}oxane-4-carboxamide
N-hydroxy-4-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzene-1-sulfinyl]methyl}oxane-4-carboxamide
N-hydroxy-4-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}oxane-4-carboxamide
N-hydroxy-6-(1H-imidazol-1-yl)-5-[4-([6-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl]ethynyl)phenyl]pyridine-3-carboxamide
-
N-hydroxy-N2-([2-[4-(phenylethynyl)phenyl]ethyl]carbamoyl)-L-threoninamide
-
N-hydroxy-N2-([[4-(phenylethynyl)phenyl]methyl]carbamoyl)-L-threoninamide
-
N-hydroxy-Nalpha-[4-(phenylethynyl)benzoyl]-L-histidinamide
-
N-[(1R)-2-(hydroxyamino)-2-oxo-1-phenylethyl]-4-(phenylethynyl)benzamide
-
N-[(1S)-2-(hydroxyamino)-2-oxo-1-phenylethyl]-4-(phenylethynyl)benzamide
-
N-[(2R)-1-(hydroxyamino)-3-(methanesulfonyl)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
-
N-[(2R)-1-(hydroxyamino)-3-(methylsulfanyl)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
-
N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-1H-indazole-3-carboxamide
-
N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
-
N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-4-(trifluoromethoxy)benzamide
-
N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-4-[(prop-2-en-1-yl)oxy]-3-(trifluoromethoxy)benzamide
-
N-[(2S)-3-amino-1-(hydroxyamino)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
-
N-[(2S)-3-amino-1-(hydroxyamino)-1-oxopropan-2-yl]-4-[4-(phenylethynyl)phenyl]piperidine-1-carboxamide
-
N-[(2S)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
-
N-[(2S)-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperazine-1-carboxamide
-
N-[(2S,3R)-3-amino-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperazine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-3-[3-(phenylethynyl)phenyl]pyrrolidine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-3-[4-(phenylethynyl)phenyl]piperidine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-3-[4-(phenylethynyl)phenyl]pyrrolidine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-((4-[(morpholin-4-yl)methyl]phenyl)ethynyl)benzamide
-
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-(4-phenylbuta-1,3-diyn-1-yl)benzamide
-
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-(4-[[4-(hydroxymethyl)phenyl]ethynyl]phenyl)piperazine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-(4-[[4-(morpholin-4-yl)phenyl]ethynyl]phenyl)piperazine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-(4-[[4-(piperazin-1-yl)phenyl]ethynyl]phenyl)piperazine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-(4-[[4-(trifluoromethyl)phenyl]ethynyl]phenyl)piperazine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-(phenylethynyl)benzamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-(phenylethynyl)piperidine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-([6-[(morpholin-4-yl)methyl]pyridin-3-yl]ethynyl)benzamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzamide
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-phenylpiperidine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4'-(morpholin-4-yl)[1,1'-biphenyl]-4-yl]piperazine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-(1,3-thiazol-5-yl)phenyl]piperazine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperazine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperidine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]piperazine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-[(4-hydroxyphenyl)ethynyl]phenyl]piperazine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-[(pyrazin-2-yl)ethynyl]phenyl]piperazine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-[(pyridin-2-yl)ethynyl]phenyl]piperazine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-[(pyridin-3-yl)ethynyl]phenyl]piperazine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-[(pyridin-4-yl)ethynyl]phenyl]piperazine-1-carboxamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-[(thiophen-2-yl)ethynyl]phenyl]piperazine-1-carboxamide
-
N-[1-(hydroxyamino)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
-
N-[1-(hydroxyamino)-2-methyl-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
-
N-[1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-(phenylethynyl)benzamide
-
N-[1-(hydroxycarbamoyl)cyclobutyl]-4-(phenylethynyl)benzamide
-
N-[1-(hydroxycarbamoyl)cyclohexyl]-4-(phenylethynyl)benzamide
-
N-[2-(hydroxyamino)-2-oxoethyl]-4-(phenylethynyl)benzamide
-
N-[3-amino-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperazine-1-carboxamide
-
compound shows good activity against Escherichia coli and Pseudomonas aeruginosa
N-[3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-(phenylethynyl)benzamide
-
compound shows good activity against Escherichia coli and Pseudomonas aeruginosa
N-[3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperidine-1-carboxamide
-
compound shows good activity against Escherichia coli and Pseudomonas aeruginosa
N-[3-hydroxy-1-(hydroxyamino)-2-methyl-1-oxopropan-2-yl][1,1'-biphenyl]-4-carboxamide
-
N-[3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperazine-1-carboxamide
-
compound shows good activity against Escherichia coli and Pseudomonas aeruginosa
N1-hydroxy-N2-[4-(phenylethynyl)benzoyl]-N4-prop-2-yn-1-yl-L-aspartamide
-
N1-hydroxy-N4-(2-methoxyethyl)-N2-[4-(phenylethynyl)benzoyl]-L-aspartamide
-
N1-hydroxy-N4-(3-hydroxypropyl)-N2-[4-(phenylethynyl)benzoyl]-L-aspartamide
-
[2-[(4R)-4-(hydroxycarbamoyl)-4,5-dihydro-1,3-oxazol-2-yl]phenyl]methyl benzoate
0.001 mg/ml, 35% inhibition
[3-(4-methoxyphenyl)-4,5-dihydro-isoxazol-5-yl]phosphonic acid
-
-
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
-
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
-
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
-
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
-
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
-
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
-
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
-
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
-
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
-
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(4-oxo-7-phenylquinazolin-3(4H)-yl)butanamide
-
-
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(4-oxo-7-phenylquinazolin-3(4H)-yl)butanamide
-
(3R,5R)-3-hydroxy-5-(2-(hydroxyamino)-2-oxoethyl)-2-(hydroxymethyl)tetrahydro-2H-pyran-4-yl tetradecanoate
-
substrate-analog LpxC inhibitor, possesses little or no antibacterial activity, because it probably cannot penetrate the Gram-negative cell envelope
(3R,5R)-3-hydroxy-5-(2-(hydroxyamino)-2-oxoethyl)-2-(hydroxymethyl)tetrahydro-2H-pyran-4-yl tetradecanoate
-
substrate-analog LpxC inhibitor, possesses little or no antibacterial activity, because it probably cannot penetrate the Gram-negative cell envelope
(4R)-2-(3,4-dimethoxy-5-propylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
i.e L-161,240
(4R)-2-(3,4-dimethoxy-5-propylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
the inhibitor is active against a Pseudomonas aeruginosa construct in which the endogenous lpxC gene is inactivated and in which LpxC activity is supplied by the lpxC gene from Escherichia coli. An Escherichia coli construct in which growth is dependent on the Pseudomonas aeruginosa lpxC gene is resistant to the compound
(4R)-2-(3,4-dimethoxy-5-propylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 96% inhibition
(4R)-2-(3-bromo-4-fluorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 66% inhibition
(4R)-2-(3-bromo-4-fluorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(4-butylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 56% inhibition
(4R)-2-(4-butylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 59% inhibition
(4R)-2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(4R)-N-hydroxy-2-(4-methoxyphenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
-
i.e. L-159,692
(4R)-N-hydroxy-2-(4-methoxyphenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 61% inhibition
(4R)-N-hydroxy-2-(4-nitrophenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
0.001 mg/ml, 57% inhibition
(4R)-N-hydroxy-2-(4-nitrophenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
-
(R)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
1 microg/ml, most potent compound
(R)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
-
-
(R)-3-(5,8-dihydronaphthalen-2-yl)-N-hydroxy-2-(naphthalene-2-sulfonamido)propanamide
-
-
(R)-3-(5,8-dihydronaphthalen-2-yl)-N-hydroxy-2-(naphthalene-2-sulfonamido)propanamide
-
-
(R)-3-(5,8-dihydronaphthalen-2-yl)-N-hydroxy-2-(naphthalene-2-sulfonamido)propanamide
-
(S)-N-(1-(2-(3,4-dimethoxy-5-propylphenyl)-4,5-dihydrooxazol-4-yl)vinyl)hydroxylamine
-
-
(S)-N-(1-(2-(3,4-dimethoxy-5-propylphenyl)-4,5-dihydrooxazol-4-yl)vinyl)hydroxylamine
-
-
(S)-N-(1-(2-(3,4-dimethoxy-5-propylphenyl)-4,5-dihydrooxazol-4-yl)vinyl)hydroxylamine
-
phenyloxazoline hydroxamic acid, competitive inhibitor in Escherichia coli, not active as an antibiotic against Aquifex aeolicus, Pseudomonas aeruginosa and other clinically important pathogens
(S)-N-(1-(2-(3,4-dimethoxy-5-propylphenyl)-4,5-dihydrooxazol-4-yl)vinyl)hydroxylamine
-
-
(S)-N-(1-(2-(3,4-dimethoxy-5-propylphenyl)-4,5-dihydrooxazol-4-yl)vinyl)hydroxylamine
-
1,5-anhydro-2-C-(carboxymethyl-N-hydroxyamide)-2-deoxy-3-O-myristoyl-D-glucitol
synthesis of the 13C-labeled substrate-analogue inhibitor, and the subsequent refinement of the solution structure of the LpxC-inhibitor complex using residual dipolar couplings. Structural basis for the design of more potent LpxC inhibitors. The best LpxC inhibitors should contain: (1) a zinc-chelating group situated between two hydrophobic molecular moieties and (2) a negatively charged group or polar group capable of forming salt bridges or hydrogen bonds with the basic patch. For the hydrophobic fragment to fit within the hydrophobic passage, a linear chemical group without branches is preferable and the total length from the hydroxamate group (which presumably binds Zn2+) to the terminal end of the linear fragment should be less than 15 A. Any hydrophobic group with a length beyond 15 A might require flexibility to fit the curved surface extending the hydrophobic passage, where the terminal methyl and the last two methylene groups of the 1,5-anhydro-2-C-(carboxymethyl-N-hydroxyamide)-2-deoxy-3-O-myristoyl-D-glucitol acyl chain are located
1,5-anhydro-2-C-(carboxymethyl-N-hydroxyamide)-2-deoxy-3-O-myristoyl-D-glucitol
-
the solution structure of LpxC in complex with the substrate-analog inhibitor 1,5-anhydro-2-C-(carboxymethyl-N-hydroxyamide)-2-deoxy-3-O-myristoyl-D-glucitol, reveals a novel alpha/beta fold, a unique zinc-binding motif and a hydrophobic passage that captures the acyl chain of the inhibitor
1,5-anhydro-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-3-O-tetradecanoyl-D-glucitol
the X-ray crystal structure of LpxC complexed with TU-514 allows for a detailed examination of the coordination geometry of the catalytic zinc ion and other enzyme-inhibitor interactions in the active site. The hydroxamate group of TU-514 forms a bidentate chelate complex with the zinc ion and makes hydrogen bond interactions with conserved active site residues E78, H265, and T191. The inhibitor C-4 hydroxyl group makes direct hydrogen bond interactions with E197 and H58. Finally, the C-3 myristate moiety of the inhibitor binds in the hydrophobic tunnel of the active site
1,5-anhydro-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-3-O-tetradecanoyl-D-glucitol
0.001 mg/ml, 51% inhibition
1,5-anhydro-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-3-O-[(3S)-3-hydroxyhexadecanoyl]-D-glucitol
-
1,5-anhydro-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-3-O-[(3S)-3-hydroxyhexadecanoyl]-D-glucitol
-
1,5-anhydro-2-deoxy-3-O-hexanoyl-2-[[hydroxy(methyl)phosphoryl]methyl]-D-glucitol
-
1,5-anhydro-2-deoxy-3-O-hexanoyl-2-[[hydroxy(methyl)phosphoryl]methyl]-D-glucitol
-
2-(5-fluoro-1H-indol-2-yl)-N-hydroxy-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
-
-
2-(5-fluoro-1H-indol-2-yl)-N-hydroxy-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
-
4-({4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]phenoxy}methyl)-N-hydroxyoxane-4-carboxamide
-
4-({4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]phenoxy}methyl)-N-hydroxyoxane-4-carboxamide
-
-
4-({4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]phenoxy}methyl)-N-hydroxyoxane-4-carboxamide
-
-
4-({4-[(4-{[(2R,6S)-2,6-dimethylmorpholin-4-yl]methyl}phenyl)ethynyl]phenoxy}methyl)-N-hydroxyoxane-4-carboxamide
-
4-({4-[(4-{[(2R,6S)-2,6-dimethylmorpholin-4-yl]methyl}phenyl)ethynyl]phenoxy}methyl)-N-hydroxyoxane-4-carboxamide
-
-
4-({4-[(4-{[(2R,6S)-2,6-dimethylmorpholin-4-yl]methyl}phenyl)ethynyl]phenoxy}methyl)-N-hydroxyoxane-4-carboxamide
-
-
4-({[4-(4-chlorophenoxy)phenyl]sulfanyl}methyl)-N-hydroxyoxane-4-carboxamide
-
4-({[4-(4-chlorophenoxy)phenyl]sulfanyl}methyl)-N-hydroxyoxane-4-carboxamide
-
-
4-({[4-(4-chlorophenoxy)phenyl]sulfanyl}methyl)-N-hydroxyoxane-4-carboxamide
-
-
4-[(4-{2-[(dimethylamino)methyl]morpholin-4-yl}phenoxy)methyl]-N-hydroxyoxane-4-carboxamide
-
4-[(4-{2-[(dimethylamino)methyl]morpholin-4-yl}phenoxy)methyl]-N-hydroxyoxane-4-carboxamide
-
-
4-[(4-{2-[(dimethylamino)methyl]morpholin-4-yl}phenoxy)methyl]-N-hydroxyoxane-4-carboxamide
-
-
4-[(4-{[4-({2-[(dimethylamino)methyl]morpholin-4-yl}methyl)phenyl]ethynyl}phenoxy)methyl]-N-hydroxyoxane-4-carboxamide
-
4-[(4-{[4-({2-[(dimethylamino)methyl]morpholin-4-yl}methyl)phenyl]ethynyl}phenoxy)methyl]-N-hydroxyoxane-4-carboxamide
-
-
4-[(4-{[4-({2-[(dimethylamino)methyl]morpholin-4-yl}methyl)phenyl]ethynyl}phenoxy)methyl]-N-hydroxyoxane-4-carboxamide
-
-
4-{[4-(4-acetylpiperazin-1-yl)phenoxy]methyl}-N-hydroxyoxane-4-carboxamide
-
4-{[4-(4-acetylpiperazin-1-yl)phenoxy]methyl}-N-hydroxyoxane-4-carboxamide
-
-
4-{[4-(4-acetylpiperazin-1-yl)phenoxy]methyl}-N-hydroxyoxane-4-carboxamide
-
-
4-{[4-({4-[(4-acetylpiperazin-1-yl)methyl]phenyl}ethynyl)phenoxy]methyl}-N-hydroxyoxane-4-carboxamide
-
4-{[4-({4-[(4-acetylpiperazin-1-yl)methyl]phenyl}ethynyl)phenoxy]methyl}-N-hydroxyoxane-4-carboxamide
-
-
4-{[4-({4-[(4-acetylpiperazin-1-yl)methyl]phenyl}ethynyl)phenoxy]methyl}-N-hydroxyoxane-4-carboxamide
-
-
5'-O-[(E)-(2,3,4-trihydroxybenzylidene)amino]uridine
-
50 microM, 80% inhibition, pH-dependent, two-step, covalent inhibitor. 2,3,4-trihydroxybenzaldehyde O-((2R,3R,4S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl oxime represents a new class of LpxC inhibitors that exploit the uridine binding site to form a covalent complex. While not antibiotic, it may provide a new scaffold for extension of existing LpxC-inhibiting antibiotics to target the UDP binding pocket
5'-O-[(E)-(2,3,4-trihydroxybenzylidene)amino]uridine
-
50 microM, 21% inhibition, pH-dependent, two-step, covalent inhibitor. 2,3,4-trihydroxybenzaldehyde O-((2R,3R,4S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl oxime represents a new class of LpxC inhibitors that exploit the uridine binding site to form a covalent complex. While not antibiotic, it may provide a new scaffold for extension of existing LpxC-inhibiting antibiotics to target the UDP binding pocket
5'-O-[(E)-(3,4-dihydroxybenzylidene)amino]uridine
-
50 microM, 60% inhibition, inhibitor as potent as (E)-2,3,4-trihydroxybenzaldehyde O-((2R,3R,4S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl oxime
5'-O-[(E)-(3,4-dihydroxybenzylidene)amino]uridine
-
50 microM, 41% inhibition
Ciprofloxacin
-
-
EDTA
-
5 mM, complete loss of activity
EDTA
-
t1/2: 4 min at 0.005 mM EDTA at 1 °C
EDTA
0.002 mM, complete inactivation, reactivated by the addition of excess heavy metal
meropenem
-
-
N,4-dihydroxy-1-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}cyclohexane-1-carboxamide
-
N,4-dihydroxy-1-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}cyclohexane-1-carboxamide
-
-
N,4-dihydroxy-1-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}cyclohexane-1-carboxamide
-
-
N-((2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl)-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamide
-
N-aroyl-L-threonine hydroxamic acid, antibiotic activity comparable to ciprofloxacin, slow, tight-binding LpxC inhibitor
N-((2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl)-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamide
as effectively as ciprofloxacin or tobramycin
N-((2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl)-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamide
-
N-aroyl-L-threonine hydroxamic acid, antibiotic activity comparable to ciprofloxacin, slow, tight-binding LpxC inhibitor
N-((2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl)-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamide
-
-
N-((2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl)-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamide
-
as effectively as ciprofloxacin or tobramycin
N-((2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl)-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamide
wild-type is insensitive to N-((2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl)-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamide
N-hydroxy-4-({4-[(4-{[4-(propan-2-yl)piperazin-1-yl]methyl}phenyl)ethynyl]phenoxy}methyl)oxane-4-carboxamide
-
N-hydroxy-4-({4-[(4-{[4-(propan-2-yl)piperazin-1-yl]methyl}phenyl)ethynyl]phenoxy}methyl)oxane-4-carboxamide
-
-
N-hydroxy-4-({4-[(4-{[4-(propan-2-yl)piperazin-1-yl]methyl}phenyl)ethynyl]phenoxy}methyl)oxane-4-carboxamide
-
-
N-hydroxy-4-({4-[4-(propan-2-yl)piperazin-1-yl]phenoxy}methyl)oxane-4-carboxamide
-
N-hydroxy-4-({4-[4-(propan-2-yl)piperazin-1-yl]phenoxy}methyl)oxane-4-carboxamide
-
-
N-hydroxy-4-({4-[4-(propan-2-yl)piperazin-1-yl]phenoxy}methyl)oxane-4-carboxamide
-
-
N-hydroxy-4-({[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenyl]sulfanyl}methyl)oxane-4-carboxamide
-
N-hydroxy-4-({[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenyl]sulfanyl}methyl)oxane-4-carboxamide
-
-
N-hydroxy-4-({[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenyl]sulfanyl}methyl)oxane-4-carboxamide
-
-
N-hydroxy-4-methoxy-1-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}cyclohexane-1-carboxamide
-
N-hydroxy-4-methoxy-1-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}cyclohexane-1-carboxamide
-
-
N-hydroxy-4-methoxy-1-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}cyclohexane-1-carboxamide
-
-
N-hydroxy-4-[(4-{4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl}phenoxy)methyl]oxane-4-carboxamide
-
N-hydroxy-4-[(4-{4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl}phenoxy)methyl]oxane-4-carboxamide
-
-
N-hydroxy-4-[(4-{4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl}phenoxy)methyl]oxane-4-carboxamide
-
-
N-hydroxy-4-[(4-{[4-({4-[2-(1H-imidazol-1-yl)ethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
-
N-hydroxy-4-[(4-{[4-({4-[2-(1H-imidazol-1-yl)ethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
-
-
N-hydroxy-4-[(4-{[4-({4-[2-(1H-imidazol-1-yl)ethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
-
-
N-hydroxy-4-[(4-{[4-({4-[2-(morpholin-4-yl)-2-oxoethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
-
N-hydroxy-4-[(4-{[4-({4-[2-(morpholin-4-yl)-2-oxoethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
-
-
N-hydroxy-4-[(4-{[4-({4-[2-(morpholin-4-yl)-2-oxoethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
-
-
N-hydroxy-4-[(4-{[4-({4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
-
N-hydroxy-4-[(4-{[4-({4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
-
-
N-hydroxy-4-[(4-{[4-({4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
-
-
N-hydroxy-4-[(4-{[4-({[(4-methoxyphenyl)methyl]amino}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
-
N-hydroxy-4-[(4-{[4-({[(4-methoxyphenyl)methyl]amino}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
-
-
N-hydroxy-4-[(4-{[4-({[(4-methoxyphenyl)methyl]amino}methyl)phenyl]ethynyl}phenoxy)methyl]oxane-4-carboxamide
-
-
N-hydroxy-4-{[4-({4-[(4-methylpiperazin-1-yl)methyl]phenyl}ethynyl)phenoxy]methyl}oxane-4-carboxamide
-
N-hydroxy-4-{[4-({4-[(4-methylpiperazin-1-yl)methyl]phenyl}ethynyl)phenoxy]methyl}oxane-4-carboxamide
-
-
N-hydroxy-4-{[4-({4-[(4-methylpiperazin-1-yl)methyl]phenyl}ethynyl)phenoxy]methyl}oxane-4-carboxamide
-
-
N-hydroxy-4-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzene-1-sulfinyl]methyl}oxane-4-carboxamide
-
N-hydroxy-4-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzene-1-sulfinyl]methyl}oxane-4-carboxamide
-
-
N-hydroxy-4-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzene-1-sulfinyl]methyl}oxane-4-carboxamide
-
-
N-hydroxy-4-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}oxane-4-carboxamide
-
N-hydroxy-4-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}oxane-4-carboxamide
-
-
N-hydroxy-4-{[4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)phenoxy]methyl}oxane-4-carboxamide
-
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzamide
-
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzamide
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzamide
-
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzamide
-
-
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzamide
-
-
RS-130830
-
tobramycin
-
-
Zn2+
-
-
Zn2+
-
0.1 mM, about 65% loss of activity
additional information
-
evaluation of LpxC inhibitors that are potent and rapidly bactericidal against multiple Gram-negative species, overview
-
additional information
-
(S)-N-(1-(2-(3,4-dimethoxy-5-propylphenyl)-4,5-dihydrooxazol-4-yl)vinyl)hydroxylamine, phenyloxazoline hydroxamic acid, competitive inhibitor in Escherichia coli, not active as an antibiotic against Aquifex aeolicus, Pseudomonas aeruginosa and other clinically important pathogens
-
additional information
(S)-N-(1-(2-(3,4-dimethoxy-5-propylphenyl)-4,5-dihydrooxazol-4-yl)vinyl)hydroxylamine and (R)-3-(5,8-dihydronaphthalen-2-yl)-N-hydroxy-2-(naphthalene-2-sulfonamido)propanamide do not inhibit Aquifex aeolicus LpxC
-
additional information
synthesis, structure, structure-activity relationship, and inhibitory potencies of tetrahydropyran-based LpxC inhibitors, overview
-
additional information
-
synthesis, structure, structure-activity relationship, and inhibitory potencies of tetrahydropyran-based LpxC inhibitors, overview
-
additional information
-
(R)-2-(4-bromophenylsulfonamido)-3-(5,8-dihydronaphthalen-2-yl)-N-hydroxypropanamide and (R)-3-(5,8-dihydronaphthalen-2-yl)-N-hydroxy-2-(naphthalene-2-sulfonamido)propanamide show predominantly gram-negative activities, with activities against members of the Enterobacteriaceae, Serratia marcescens, Morganella morganii, Moraxella catarrhalis, Haemophilus influenzae, and Burkholderia cepacia. Neither compound showed activity against Pseudomonas aeruginosa; however, against a leaky Pseudomonas aeruginosa strain, some activity is seen with (R)-3-(5,8-dihydronaphthalen-2-yl)-N-hydroxy-2-(naphthalene-2-sulfonamido)propanamide. (R)-2-(4-bromophenylsulfonamido)-3-(5,8-dihydronaphthalen-2-yl)-N-hydroxypropanamide and (R)-3-(5,8-dihydronaphthalen-2-yl)-N-hydroxy-2-(naphthalene-2-sulfonamido)propanamide have little or no activity against the gram-positive bacteria tested
-
additional information
-
incubation of 10 nM LpxC in buffer without bovine serum albumin for 30 min completely inactivates the enzyme. When this enzyme is diluted further (4fold) into buffer containing 1 mg/ml bovine serum albumin, 100% of the activity is restored when assayed after a 2 h incubation. High concentrations of LpxC in the assays can eliminate the requirement of bovine serum albumin
-
additional information
-
the affinity of LpxC for both product and fatty acids is significantly influenced by changes in the number and identity of metal ions bound to the LpxC active site. Therefore, interactions with these metal ions are critical for molecular recognition of ligands by LpxC and may mimic similar contacts with active site inhibitors. These data indicate that the potency of LpxC inhibitors in vitro can be altered by assay conditions used in screening and/or development of LpxC inhibitors and that the metal ion status of LpxC in vivo will likely influence the effectiveness of LpxC inhibitors as antibiotics
-
additional information
-
dithiothreitol, glutathione and the C207A mutant prevent the formation of a covalent complex by (E)-2,3,4-trihydroxybenzaldehyde O-((2R,3R,4S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl oxime; no inhibitory effect by 2,4-dihydroxy-benzaldehyde O-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-oxime, 3,4-dimethoxy-benzaldehyde O-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-oxime, and 2,3,4-trimethoxy-benzaldehyde O-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-oxime
-
additional information
-
mass spectrometry-based screening is a valuable high-throughput screening tool for detecting inhibitors of enzymatic targets involving difficult to detect reactions
-
additional information
-
study the potentially important structural differences in active sites of both proteins responsible for making the inhibitors selective for Escherichia coli as compared to Pseudomonas aeruginosa LpxC, homology models of the LpxC of both organisms are developed and validated on the basis of a 3D profile and PROCHECK. Subsequently, a molecular electrostatic potential (MEP)-based surface and cavity-depth analysis is performed. Finally, a cross-docking analysis of reported inhibitors is performed to reveal selective binding modes. These studies identify differences between the two active sites and have implications for designing effective strategies to identify LpxC inhibitors that can be developed as novel broad-spectrum antibacterial drugs
-
additional information
-
synthesis, structure, structure-activity relationship, and inhibitory potencies of tetrahydropyran-based LpxC inhibitors, overview
-
additional information
-
structure-guided drug discovery of broad spectrum Gram-negative antibiotics, overview
-
additional information
-
development of novel LpxC inhibitors, chiral-pool synthesis of C-triazolyl glycosides, biological activity against Escherichia coli strains BL21(DE3) and D22, overview
-
additional information
-
C-triazolyl beta-D-furanosides as LpxC inhibitors, stereoselective synthesis and evaluation, biological activity against Escherichia coli strains BL21(DE3) and D22, overview
-
additional information
-
synthesis and biological evaluation of C-ethynyl furanosides as enzyme LpxC inhibitors, biological activity against Escherichia coli strains BL21(DE3) and D22, overview
-
additional information
-
evaluation of LpxC inhibitors that are potent and rapidly bactericidal against multiple Gram-negative species, overview
-
additional information
-
(4R)-2-(3,4-dimethoxy-5-propylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide is active against a Pseudomonas aeruginosa construct in which the endogenous lpxC gene is inactivated and in which LpxC activity is supplied by the lpxC gene from Escherichia coli. An Escherichia coli construct in which growth is dependent on the Pseudomonas aeruginosa lpxC gene is resistant to the compound
-
additional information
study the potentially important structural differences in active sites of both proteins responsible for making the inhibitors selective for Escherichia coli as compared to Pseudomonas aeruginosa LpxC, homology models of the LpxC of both organisms are developed and validated on the basis of a 3D profile and PROCHECK. Subsequently, a molecular electrostatic potential (MEP)-based surface and cavity-depth analysis is performed. Finally, a cross-docking analysis of reported inhibitors is performed to reveal selective binding modes. These studies identify differences between the two active sites and have implications for designing effective strategies to identify LpxC inhibitors that can be developed as novel broad-spectrum antibacterial drugs
-
additional information
-
study the potentially important structural differences in active sites of both proteins responsible for making the inhibitors selective for Escherichia coli as compared to Pseudomonas aeruginosa LpxC, homology models of the LpxC of both organisms are developed and validated on the basis of a 3D profile and PROCHECK. Subsequently, a molecular electrostatic potential (MEP)-based surface and cavity-depth analysis is performed. Finally, a cross-docking analysis of reported inhibitors is performed to reveal selective binding modes. These studies identify differences between the two active sites and have implications for designing effective strategies to identify LpxC inhibitors that can be developed as novel broad-spectrum antibacterial drugs
-
additional information
-
synthesis, structure, structure-activity relationship, and inhibitory potencies of tetrahydropyran-based LpxC inhibitors, overview
-
additional information
-
evaluation of LpxC inhibitors that are potent and rapidly bactericidal against multiple Gram-negative species, overview
-
additional information
structure-based drug design, inhibitor binding structures, overview
-
additional information
-
structure-based drug design, inhibitor binding structures, overview
-
additional information
no evidence of time-dependent inhibition is observed in assays with either the wild-type or mutants
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0000261
(2R)-4-(2'-ethyl[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000136
(2R)-4-(2'-fluoro[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
-
0.00000354
(2R)-4-(3'-chloro[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000049
(2R)-4-(3-fluoro-2-oxo-4-phenylpyridin-1(2H)-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000064
(2R)-4-(4'-cyano[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000174
(2R)-4-(4'-fluoro[1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000011
(2R)-4-(4-cyclohexyl-2-oxopyridin-1(2H)-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000069
(2R)-4-(4-tert-butyl-2-oxopyridin-1(2H)-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000023
(2R)-4-(5-fluoro-2-oxo-4-phenylpyridin-1(2H)-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000001 - 0.000041
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
0.00000681
(2R)-4-[3-(2,3-difluorophenyl)-1,2-oxazol-5-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000532
(2R)-4-[3-(2-fluoro-3-methoxyphenyl)-1,2-oxazol-5-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000044
(2R)-4-[3-(2-fluoro-4-methoxyphenyl)-1,2-oxazol-5-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000127
(2R)-4-[4'-(3-aminopropoxy)[1,1'-biphenyl]-4-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000949
(2R)-4-[4'-(3-carbamimidamidopropoxy)[1,1'-biphenyl]-4-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000129
(2R)-4-[4'-(aminomethyl)[1,1'-biphenyl]-4-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000195
(2R)-4-[4-(2,3-dichlorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000808
(2R)-4-[4-(2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000044
(2R)-4-[4-(2,5-difluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000048
(2R)-4-[4-(2,6-difluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000471
(2R)-4-[4-(2-chloro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000018
(2R)-4-[4-(2-fluoro-3-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000012
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
-
0.000000069 - 0.000183
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
0.0000022
(2R)-4-[4-(2-fluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000012
(2R)-4-[4-(2H-1,3-benzodioxol-5-yl)phenyl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000167
(2R)-4-[4-(3,4-dichlorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000187
(2R)-4-[4-(3,4-difluorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000039
(2R)-4-[4-(3,5-difluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000053
(2R)-4-[4-(3,5-dimethylphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000002
(2R)-4-[4-(3-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000003
(2R)-4-[4-(3-fluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000052
(2R)-4-[4-(4-chloro-2,3-difluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000000657
(2R)-4-[4-(4-chloro-2-fluorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000011
(2R)-4-[4-(4-chloro-2-fluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000000912
(2R)-4-[4-(4-chloro-3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000029
(2R)-4-[4-(4-fluorophenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000516
(2R)-4-[4-(benzyloxy)phenyl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000041
(2R)-4-[4-(cyclohex-1-en-1-yl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000101
(2R)-4-[4-(cyclopentyloxy)phenyl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000266
(2R)-4-[5-(2,3-dichlorophenyl)-1,2-oxazol-3-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000232
(2R)-4-[5-(2-fluoro-4-methoxyphenyl)-1,2-oxazol-3-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000831
(2R)-4-[5-(2-fluorophenyl)-1,2-oxazol-3-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000675
(2R)-4-[5-(3-fluorophenyl)-1,2-oxazol-3-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000003
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(1-phenyl-1H-1,2,3-triazol-4-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000135
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(1-phenyl-1H-pyrazol-4-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00006
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2'-oxo[2,4'-bipyridin]-1'(2'H)-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000068 - 0.00011
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
0.000057
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyrimidin-1(2H)-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000039
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo[4,4'-bipyridin]-1(2H)-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000067
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000302
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(3-phenyl-1,2-oxazol-5-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000023
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(4-oxo-7-phenylquinazolin-3(4H)-yl)butanamide
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.00000085
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(4-phenyl-1H-1,2,3-triazol-1-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000161
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(4-phenyl-1H-pyrazol-1-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00003
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(5-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000000511
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(5-phenyl-1,2-oxazol-3-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000013
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(5-phenylpyridin-2-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000022
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(6-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000085
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(6-oxo-4-phenylpyrimidin-1(6H)-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000049
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(6-phenylpyridin-3-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000015
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-(2,3,4-trifluorophenyl)pyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000006
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-(2-phenylethyl)pyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000018
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-(phenylethynyl)pyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000032
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[(E)-2-phenylethenyl]pyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000011
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[4-(1,3-thiazol-2-yl)phenyl]pyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000053
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[4-(2H-1,2,3-triazol-2-yl)phenyl]pyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000013
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[4-(pyridin-2-yl)phenyl]pyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000012
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[2-oxo-4-[4-(pyridin-4-yl)phenyl]pyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000221
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[3'-(1H-pyrazol-1-yl)[1,1'-biphenyl]-4-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000678
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[3'-(propan-2-yl)[1,1'-biphenyl]-4-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000293
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[3-(4-methylphenyl)-1,2-oxazol-5-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000139
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-(4-methylphenyl)-1H-1,2,3-triazol-1-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000012
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-(naphthalen-2-yl)-2-oxopyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000304
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-(phenylsulfanyl)phenyl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000297
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-(pyridin-3-yl)phenyl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000216
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-[(pyridin-4-yl)oxy]phenyl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000011
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-[4-[4-(1,2-oxazol-3-yl)phenyl]-2-oxopyridin-1(2H)-yl]butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000704
(2R)-N-hydroxy-2-(methanesulfonyl)-4-(2'-methoxy[1,1'-biphenyl]-4-yl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000064
(2R)-N-hydroxy-2-(methanesulfonyl)-4-(6-methoxy-2'-oxo[3,4'-bipyridin]-1'(2'H)-yl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000012
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-(2-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000037
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-(3-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000026
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-(4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000002
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-[4-(2-methoxypyrimidin-5-yl)phenyl]-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000012
(2R)-N-hydroxy-2-(methanesulfonyl)-4-[4-[4-(5-methoxypyrimidin-2-yl)phenyl]-2-oxopyridin-1(2H)-yl]-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000053
(2R)-N-hydroxy-4-(2-hydroxy-6-phenylpyridin-3-yl)-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000185
(2R)-N-hydroxy-4-[4'-(hydroxyacetyl)[1,1'-biphenyl]-4-yl]-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.01
(2R,3R,4S,5S)-N,3,4-trihydroxy-5-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]oxolane-2-carboxamide
Escherichia coli
-
37°C, pH 6.0
200
(2S)-N,3-dihydroxy-2-[(1S)-2-hydroxy-1-[4-(phenylethynyl)phenyl]ethoxy]propanamide
Escherichia coli
pH not specified in the publication, 30°C
2.6
(2S)-N,3-dihydroxy-2-[(1S)-2-hydroxy-1-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]ethoxy]propanamide
Escherichia coli
pH not specified in the publication, 30°C
0.0000044
(2S)-N1-hydroxy-2-[4-(phenylethynyl)benzamido]butanediamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000008
(2S,3R)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1,2-oxazol-5-yl)propanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000003
(2S,3R)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1,3-oxazol-2-yl)propanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000004
(2S,3R)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00005
(2S,3R)-2-[5-([1,1'-biphenyl]-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]-N,3-dihydroxybutanamide
Escherichia coli
pH not specified in the publication, 30°C
0.000971
(2S,3R)-2-[5-[([1,1'-biphenyl]-3-yl)ethynyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl]-N,3-dihydroxybutanamide
Escherichia coli
pH not specified in the publication, 30°C
0.000013
(2S,3R)-2-[5-[([1,1'-biphenyl]-4-yl)ethynyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl]-N,3-dihydroxybutanamide
Escherichia coli
pH not specified in the publication, 30°C
0.041
(2S,3R)-N,3-dihydroxy-2-(1-oxo-5-phenyl-1,3-dihydro-2H-isoindol-2-yl)butanamide
Escherichia coli
pH not specified in the publication, 30°C
0.00013
(2S,3R)-N,3-dihydroxy-2-[1-oxo-5-(phenylethynyl)-1,3-dihydro-2H-isoindol-2-yl]butanamide
Escherichia coli
pH not specified in the publication, 30°C
0.000029
(2S,3R)-N,3-dihydroxy-2-[1-oxo-5-[4-(phenylethynyl)phenyl]-1,3-dihydro-2H-isoindol-2-yl]butanamide
Escherichia coli
pH not specified in the publication, 30°C
0.034
(2S,3R)-N,3-dihydroxy-2-[1-oxo-6-(phenylethynyl)-1,3-dihydro-2H-isoindol-2-yl]butanamide
Escherichia coli
pH not specified in the publication, 30°C
0.0002
(2S,3R)-N,3-dihydroxy-2-[3-oxo-6-(phenylethynyl)-1,3-dihydro-2H-indazol-2-yl]butanamide
Escherichia coli
pH not specified in the publication, 30°C
0.2
(2S,3R,4S,5R)-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-N,3,4-trihydroxyoxolane-2-carboxamide
Escherichia coli
-
pH 6.0, 37°C
0.2
(2S,3R,4S,5R)-5-(1-hexyl-1H-1,2,3-triazol-4-yl)-N,3,4-trihydroxyoxolane-2-carboxamide
Escherichia coli
-
pH 6.0, 37°C
0.2
(2S,3R,4S,5R)-5-[1-[(4-fluorophenyl)methyl]-1H-1,2,3-triazol-4-yl]-N,3,4-trihydroxyoxolane-2-carboxamide
Escherichia coli
-
pH 6.0, 37°C
0.2
(2S,3R,4S,5R)-N,3,4-trihydroxy-5-(1-phenyl-1H-1,2,3-triazol-4-yl)oxolane-2-carboxamide
Escherichia coli
-
pH 6.0, 37°C
0.2
(2S,3R,4S,5R)-N,3,4-trihydroxy-5-(1-[[4-(trifluoromethyl)phenyl]methyl]-1H-1,2,3-triazol-4-yl)oxolane-2-carboxamide
Escherichia coli
-
pH 6.0, 37°C
0.2
(2S,3R,4S,5R)-N,3,4-trihydroxy-5-(2-(4-[2-(4-methoxyphenyl)ethynyl]phenyl)ethynyl)tetrahydrofuran-2-carboxamide
Escherichia coli
-
above, pH 6.0, 37°C
0.2
(2S,3R,4S,5R)-N,3,4-trihydroxy-5-(octa-1,3-diyn-1-yl)tetrahydrofuran-2-carboxamide
Escherichia coli
-
above, pH 6.0, 37°C
0.2
(2S,3R,4S,5R)-N,3,4-trihydroxy-5-(phenylbuta-1,3-diyn-1-yl)tetrahydrofuran-2-carboxamide
Escherichia coli
-
above, pH 6.0, 37°C
0.107
(2S,3R,4S,5R)-N,3,4-trihydroxy-5-([4-(phenylethynyl)phenyl]ethynyl)tetrahydrofuran-2-carboxamide
Escherichia coli
-
above, pH 6.0, 37°C
0.2
(2S,3R,4S,5R)-N,3,4-trihydroxy-5-[1-(2-phenylethyl)-1H-1,2,3-triazol-4-yl]oxolane-2-carboxamide
Escherichia coli
-
pH 6.0, 37°C
0.2
(2S,3R,4S,5R)-N,3,4-trihydroxy-5-[1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl]oxolane-2-carboxamide
Escherichia coli
-
pH 6.0, 37°C
0.2
(2S,3R,4S,5R)-N,3,4-trihydroxy-5-[2-(4-(2-[4-(trifluoromethyl)phenyl]ethynyl)phenyl)ethynyl]tetrahydrofuran-2-carboxamide
Escherichia coli
-
above, pH 6.0, 37°C
0.2
(2S,3R,4S,5S)-5-(1-benzyl-1H-1,2,3-triazol-4-yl)-N,3,4-trihydroxytetrahydrofuran-2-carboxamide
Escherichia coli
-
above, pH 6.0, 37°C
0.2
(2S,3R,4S,5S)-5-[1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl]-N,3,4-trihydroxytetrahydrofuran-2-carboxamide
Escherichia coli
-
above, pH 6.0, 37°C
0.2
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-((4-[(4-methoxyphenyl)ethynyl]phenyl)ethynyl)tetrahydrofuran-2-carboxamide
Escherichia coli
-
above, pH 6.0, 37°C
0.2
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-(1-phenethyl-1H-1,2,3-triazol-4-yl)tetrahydrofuran-2-carboxamide
Escherichia coli
-
above, pH 6.0, 37°C
0.2
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-(1-phenyl-1H-1,2,3-triazol-4-yl)tetrahydrofuran-2-carboxamide
Escherichia coli
-
above, pH 6.0, 37°C
0.2
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-(1-[4-(trifluoromethyl)benzyl]-1H-1,2,3-triazol-4-yl)tetrahydrofuran-2-carboxamide
Escherichia coli
-
above, pH 6.0, 37°C
0.2
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-(phenylbuta-1,3-diyn-1-yl)tetrahydrofuran-2-carboxamide
Escherichia coli
-
above, pH 6.0, 37°C
0.2
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-([4-(phenylethynyl)phenyl]ethynyl)tetrahydrofuran-2-carboxamide
Escherichia coli
-
above, pH 6.0, 37°C
0.2
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-[(4-([4-(trifluoromethyl)phenyl]ethynyl)phenyl)ethynyl]tetrahydrofuran-2-carboxamide
Escherichia coli
-
above, pH 6.0, 37°C
0.2
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-[1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl]tetrahydrofuran-2-carboxamide
Escherichia coli
-
above, pH 6.0, 37°C
0.0305 - 0.032
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-[4-(4-phenylbuta-1,3-diyn-1-yl)phenyl]oxolane-2-carboxamide
0.2
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]oxolane-2-carboxamide
Escherichia coli
-
pH 6.0, 37°C
0.000028
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-5-ethoxy-N,3-dihydroxy-2-methylpentanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000072
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2,4-dimethylpentanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000004
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1,2-oxazol-3-yl)propanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000026
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1-methyl-1H-1,2,3-triazol-5-yl)propanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000025
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1-methyl-1H-imidazol-2-yl)propanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000004
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(1H-pyrazol-5-yl)propanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000004
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(5-methyl-1,2-oxazol-3-yl)propanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000015
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(pyridin-2-yl)propanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000018
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-(pyridin-3-yl)propanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000051
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methyl-3-phenylpropanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000003
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00009
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylheptanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000008 - 0.00016
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylpentanamide
0.0000008
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-3-(1H-imidazol-5-yl)-2-methylpropanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000006
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-3-[5-(hydroxymethyl)-1,2-oxazol-3-yl]-2-methylpropanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.087
(2S,4S,5S)-N,4-dihydroxy-5-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]oxolane-2-carboxamide
Escherichia coli
-
37°C, pH 6.0
0.022
(3-(4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)methanethiol
Escherichia coli
-
pH 6.0, 30°C
0.016
(3S,4R)-N,3,4-trihydroxy-1-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzoyl]-L-prolinamide
Escherichia coli
-
37°C, pH 6.0
0.01
(4R)-2-(1-butyl-1H-indazol-3-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.012
(4R)-2-(2-butyl-2H-indazol-3-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
26 - 75
(4R)-2-(3,4-dimethoxy-5-propylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
0.0049
(4R)-2-(3-bromo-4-fluorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0096
(4R)-2-(3-bromo-5-fluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0003
(4R)-2-(3-chloro-5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0012
(4R)-2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0096
(4R)-2-(3-fluoro-4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00084
(4R)-2-(3-fluoro-4-[[3-(trifluoromethyl)phenyl]methoxy]phenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.018
(4R)-2-(4-acetylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0027
(4R)-2-(4-bromophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0073
(4R)-2-(4-butylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0012
(4R)-2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00096
(4R)-2-(4-fluoro-3-propylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.006
(4R)-2-(4-fluorophenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0016
(4R)-2-(5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0328
(4R)-2-[3-chloro-4-(trifluoromethoxy)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0014
(4R)-2-[3-fluoro-4-[(prop-2-en-1-yl)oxy]phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0049
(4R)-2-[4-(dimethylamino)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00025
(4R)-2-[4-[(3-fluorophenyl)methoxy]-3-(trifluoromethoxy)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00035
(4R)-2-[4-[(but-3-en-1-yl)oxy]-3-(trifluoromethoxy)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0056
(4R)-2-[4-[(but-3-en-1-yl)oxy]phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0587
(4R)-2-[4-[(but-3-en-1-yl)oxy]phenyl]-N-hydroxy-4,5-dihydro-1,3-thiazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0033
(4R)-2-[5-fluoro-4-methoxy-2-methyl-3-(prop-2-en-1-yl)phenyl]-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.103
(4R)-N,4-dihydroxy-1-[4-(phenylethynyl)benzoyl]-L-prolinamide
Escherichia coli
-
37°C, pH 6.0
0.0479
(4R)-N,4-dihydroxy-1-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzoyl]-L-prolinamide
Escherichia coli
-
37°C, pH 6.0
0.0059
(4R)-N,4-dihydroxy-1-[4-[(4-pentylphenyl)ethynyl]benzoyl]-L-prolinamide
Escherichia coli
-
37°C, pH 6.0
0.0621
(4R)-N,4-dihydroxy-1-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]methyl]-L-prolinamide
Escherichia coli
-
37°C, pH 6.0
0.0055
(4R)-N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00028
(4R)-N-hydroxy-2-(4'-propyl[1,1'-biphenyl]-4-yl)-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0055
(4R)-N-hydroxy-2-(4-iodophenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
2500 - 2600
(4R)-N-hydroxy-2-(4-methoxyphenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
0.02
(4R)-N-hydroxy-2-(4-methylphenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0385
(4R)-N-hydroxy-2-(4-methylphenyl)-4,5-dihydro-1,3-thiazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0054
(4R)-N-hydroxy-2-(4-nitrophenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0078
(4R)-N-hydroxy-2-[4-(trifluoromethyl)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0178
(4R)-N-hydroxy-2-[4-methoxy-3,5-bis(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-thiazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00016
(4R)-N-hydroxy-2-[4-methoxy-3-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0005
(4R)-N-hydroxy-2-[4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00019
(4R)-N-hydroxy-2-[4-[(3-methylbut-2-en-1-yl)oxy]-3-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00056
(4R)-N-hydroxy-2-[4-[(3-nitrophenoxy)methyl]phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0013
(4R)-N-hydroxy-2-[4-[(3-nitrophenyl)methoxy]phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00012
(4R)-N-hydroxy-2-[4-[(prop-2-en-1-yl)oxy]-3-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0022
(4R)-N-hydroxy-2-[4-[(prop-2-en-1-yl)oxy]-3-(trifluoromethyl)phenyl]-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.01
(4R)-N-hydroxy-2-[6-(trifluoromethyl)pyridin-3-yl]-4,5-dihydro-1,3-oxazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0167
(4S)-1-(4-[[4-(dimethylamino)phenyl]ethynyl]benzoyl)-N,4-dihydroxy-L-prolinamide
Escherichia coli
-
37°C, pH 6.0
0.0659
(4S)-4-fluoro-N-hydroxy-1-[4-(phenylethynyl)benzoyl]-L-prolinamide
Escherichia coli
-
37°C, pH 6.0
0.044
(4S)-N,4-dihydroxy-1-[4-([4-[(4-hydroxypiperidin-1-yl)methyl]phenyl]ethynyl)benzoyl]-L-prolinamide
Escherichia coli
-
37°C, pH 6.0
0.0295
(4S)-N,4-dihydroxy-1-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzoyl]-L-prolinamide
Escherichia coli
-
37°C, pH 6.0
0.0545
(4S)-N,4-dihydroxy-1-[4-([4-[(piperidin-1-yl)methyl]phenyl]ethynyl)benzoyl]-L-prolinamide
Escherichia coli
-
37°C, pH 6.0
0.0328
(4S)-N,4-dihydroxy-1-[4-([4-[(thiomorpholin-4-yl)methyl]phenyl]ethynyl)benzoyl]-L-prolinamide
Escherichia coli
-
37°C, pH 6.0
0.0178
(R)-(hydroxyamino)((R)-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrothiazol-4-yl)methanol
Pseudomonas aeruginosa
-
-
0.01
(R)-2-(1-butyl-1H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.012
(R)-2-(2-butyl-2H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.000097
(R)-2-(3,4-dimethoxy-5-propylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Escherichia coli
-
-
0.00033
(R)-2-(3,5-difluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Escherichia coli
-
-
0.0068
(R)-2-(3,5-difluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Escherichia coli
-
-
0.001
(R)-2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00025
(R)-2-(4-(3-fluorobenzyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0022
(R)-2-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0049
(R)-2-(4-(dimethylamino)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00075
(R)-2-(4-(hexyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Escherichia coli
-
-
0.0004
(R)-2-(4-bromophenylsulfonamido)-3-(5,8-dihydronaphthalen-2-yl)-N-hydroxypropanamide
Escherichia coli
-
-
0.025
(R)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0012
(R)-2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00016
(R)-3-(5,8-dihydronaphthalen-2-yl)-N-hydroxy-2-(naphthalene-2-sulfonamido)propanamide
Escherichia coli
-
-
0.138
(R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-2-isopropyl-4-oxobutanamide
Pseudomonas aeruginosa
-
-
0.00891
(R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-2-methyl-4-oxobutanamide
Pseudomonas aeruginosa
-
-
0.003
(R)-N-(1-(2-(3,4-dimethoxy-5-propylphenyl)-4,5-dihydrooxazol-4-yl)vinyl)hydroxylamine
Escherichia coli
-
pH 6.0, 30°C
0.013
(R)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-1H-indazole-3-carboxamide
Pseudomonas aeruginosa
-
-
0.0055
(R)-N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0016
(R)-N-hydroxy-2-(2,3,5-trifluoro-4-methoxyphenyl)-4,5-dihydrooxazole-4-carboxamide
Escherichia coli
-
-
0.00056
(R)-N-hydroxy-2-(4-((3-nitrophenoxy)methyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.001
(R)-N-hydroxy-2-(4-(3-nitrobenzyloxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00016
(R)-N-hydroxy-2-(4-methoxy-3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0005
(R)-N-hydroxy-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0385
(R)-N-hydroxy-2-p-tolyl-4,5-dihydrothiazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0162
(S)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-4,5-dihydroisoxazole-5-carboxamide
Pseudomonas aeruginosa
-
-
0.0229
(S)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-5-methyl-4,5-dihydroisoxazole-5-carboxamide
Pseudomonas aeruginosa
-
-
0.00437
(S)-3-(4-methoxyphenyl)-4,5-dihydro-isoxazole-5-carboxylic acid hydroxyamide
Escherichia coli
-
pH 6.0, 30°C
0.00891
(S)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-2-methyl-4-oxobutanamide
Pseudomonas aeruginosa
-
-
0.00044
(S)-N-(1-(2-(3,4-dimethoxy-5-propylphenyl)-4,5-dihydrooxazol-4-yl)vinyl)hydroxylamine
Escherichia coli
-
-
0.0072
1,5-anhydro-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-3-O-tetradecanoyl-D-glucitol
Escherichia coli
pH not specified in the publication, 30°C
0.002 - 0.0181
1,5-anhydro-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-3-O-[(3S)-3-hydroxyhexadecanoyl]-D-glucitol
0.115 - 0.192
1,5-anhydro-2-deoxy-3-O-hexanoyl-2-[[hydroxy(methyl)phosphoryl]methyl]-D-glucitol
0.000208
1-benzyl-N-hydroxy-4-[4-(phenylethynyl)benzamido]piperidine-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000927
1-hydroxy-4-[4-[(3R)-4-(hydroxyamino)-3-(methanesulfonyl)-3-methyl-4-oxobutyl]phenoxy]pyridin-1-ium
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0171
1-[4-([4-[(1,1-dioxo-1lambda6-thiomorpholin-4-yl)methyl]phenyl]ethynyl)benzoyl]-N-hydroxy-L-prolinamide
Escherichia coli
-
37°C, pH 6.0
0.01
2-(1-butyl-1H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.012
2-(2-butyl-2H-indazol-3-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.000162
2-(3,4-bis(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0204
2-(3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)-N-hydroxyacetamide
Pseudomonas aeruginosa
-
-
0.001 - 0.0033
2-(3-allyl-5-fluoro-4-methoxy-2-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0049 - 0.00501
2-(3-bromo-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.009 - 0.00912
2-(3-bromo-5-fluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.03 - 0.0302
2-(3-chloro-4-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0003 - 0.00159
2-(3-chloro-5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.001 - 0.0468
2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0096
2-(3-fluoro-4-(2-(trifluoromethyl)benzyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00084
2-(3-fluoro-4-(3-(trifluoromethyl)benzyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.000851
2-(3-fluoro-4-(3-methylbenzyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.025 - 0.0251
2-(3-fluoro-5-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.00025 - 0.000251
2-(4-(3-fluorobenzyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.00012
2-(4-(allyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0022 - 0.00223
2-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0014
2-(4-(allyloxy)-3-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00035 - 0.000355
2-(4-(but-3-enyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0056 - 0.00562
2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0587 - 0.0589
2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrothiazole-4-carboxamide
0.0049 - 0.00501
2-(4-(dimethylamino)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.018 - 0.0182
2-(4-acetylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0027
2-(4-bromophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0073 - 0.007413
2-(4-butylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0013 - 0.00132
2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0212
2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0012
2-(4-fluoro-3-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.000955 - 0.00096
2-(4-fluoro-3-propylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0625
2-(4-fluorophenyl)-N-hydroxy-4,5-dihydro-1,3-thiazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.006 - 0.00603
2-(4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
0.0625
2-(4-fluorophenyl)-N-hydroxy-4,5-dihydrothiazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0016
2-(5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0312
2-(5-fluoro-1H-indol-2-yl)-N-hydroxy-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
0.027
2-mercapto-1-[3-(4-methoxyphenyl)-4,5-dihydro-isoxazol-5-yl]ethanone
Escherichia coli
-
racemate, pH 6.0, 30°C
0.012
2-thioacetyl-1-[3-(4-methoxyphenyl)-4,5-dihydro-isoxazol-5-yl]ethanone
Escherichia coli
-
racemate, pH 6.0, 30°C
0.000022
2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylpropanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0211
2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-hydroxy-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00039
2-[[([1,1'-biphenyl]-4-yl)oxy]methyl]-N,3-dihydroxy-2-methylpropanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000002
2-[[4-(diethylamino)-2-hydroxyphenyl]carbonyl]benzoic acid
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.03
3,4-dihydroxy-benzaldehyde O-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-oxime
Escherichia coli
-
-
0.0138
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide
Pseudomonas aeruginosa
-
-
0.0162
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxylic acid
Pseudomonas aeruginosa
-
-
0.479
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-4,5-dihydroisoxazole-5-carboxamide
Pseudomonas aeruginosa
-
-
0.0263
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-5-methyl-4,5-dihydroisoxazole-5-carboxamide
Pseudomonas aeruginosa
-
-
0.00661
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-5-propyl-4,5-dihydroisoxazole-5-carboxamide
Pseudomonas aeruginosa
-
-
0.00427
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-N-methyl-4,5-dihydroisoxazole-5-carboxamide
Pseudomonas aeruginosa
-
-
0.17
3-(4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl(methyl)phosphinic acid
Escherichia coli
-
pH 6.0, 30°C
0.0000119
3-([1,1'-biphenyl]-4-sulfonyl)-N-hydroxy-2-(methanesulfonyl)-2-methylpropanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.046
3-ethoxy-4-fluoro-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
Pseudomonas aeruginosa
-
-
0.0476
3-ethoxy-4-fluoro-N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000314
3-[([1,1'-biphenyl]-4-yl)oxy]-N-hydroxy-2-(methanesulfonyl)-2-methylpropanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000904
3-[([1,1'-biphenyl]-4-yl)sulfanyl]-N-hydroxy-2-(methanesulfonyl)-2-methylpropanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000008
4'-ethyl-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl][1,1'-biphenyl]-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000278
4'-[(3R)-4-(hydroxyamino)-3-(methanesulfonyl)-3-methyl-4-oxobutyl][1,1'-biphenyl]-3-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000736
4'-[(3R)-4-(hydroxyamino)-3-(methanesulfonyl)-3-methyl-4-oxobutyl][1,1'-biphenyl]-4-carboxylic acid
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00427
4-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-oxobutanoic acid
Pseudomonas aeruginosa
-
-
0.0148
4-(3-(cyclopentyloxy)-4-methoxyphenyl)-N-hydroxy-4-oxobutanamide
Pseudomonas aeruginosa
-
-
0.000011
4-(4-[[4-(cyanomethyl)phenyl]ethynyl]phenyl)-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.0075 - 0.00759
4-(allyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-3-(trifluoromethoxy)benzamide
0.0039 - 0.00398
4-(but-3-enyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
0.0000033
4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(hydroxymethyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000138
4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000007
4-([1,1'-biphenyl]-4-yl)-N-[(2S)-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.0000025
4-([1,1'-biphenyl]-4-yl)-N-[(2S)-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]piperidine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.0000056
4-([1,1'-biphenyl]-4-yl)-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.0000138
4-([1,1'-biphenyl]-4-yl)-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]piperidine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.0000212
4-([4'-[(3R)-4-(hydroxyamino)-3-(methanesulfonyl)-3-methyl-4-oxobutyl][1,1'-biphenyl]-4-yl]oxy)butanoic acid
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000026
4-([4-[(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]methyl]phenyl)ethynyl]phenoxy]methyl)-N-hydroxyoxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000074
4-([[4-(4-chlorophenoxy)phenyl]sulfanyl]methyl)-N-hydroxyoxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000058
4-[(4-[[4-([2-[(dimethylamino)methyl]morpholin-4-yl]methyl)phenyl]ethynyl]phenoxy)methyl]-N-hydroxyoxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0039
4-[(but-3-en-1-yl)oxy]-N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000026
4-[4-[(4-aminophenyl)ethynyl]phenyl]-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.000005
4-[4-[(4-chlorophenyl)ethynyl]phenyl]-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.000007
4-[4-[(4-fluorophenyl)ethynyl]phenyl]-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.0000087
4-[[([1,1'-biphenyl]-4-yl)oxy]methyl]-N-hydroxyoxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000014
4-[[4-(benzyloxy)phenoxy]methyl]-N-hydroxyoxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000003
4-[[4-([4-[(4-acetylpiperazin-1-yl)methyl]phenyl]ethynyl)phenoxy]methyl]-N-hydroxyoxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.12
5'-deoxy-5'-[2-([(E)-[(2,3,4-trihydroxyphenyl)methylidene]amino]oxy)acetamido]uridine
Escherichia coli
pH not specified in the publication, 30°C
0.027
5'-O-[(E)-(2,3,4-trihydroxybenzylidene)amino]uridine
Escherichia coli
-
-
0.027
5'-O-[(E)-[(2,3,4-trihydroxyphenyl)methylidene]amino]uridine
Escherichia coli
pH not specified in the publication, 30°C
0.03
5'-O-[(E)-[(3,4-dihydroxyphenyl)methylidene]amino]uridine
Escherichia coli
pH not specified in the publication, 30°C
0.0007
5-ethyl-5-(2-oxo-2-[4-[4-(phenylethynyl)phenyl]piperidin-1-yl]ethyl)imidazolidine-2,4-dione
Escherichia coli
pH not specified in the publication, 30°C
0.0005
5-methyl-5-(2-oxo-2-[4-[4-(phenylethynyl)phenyl]piperazin-1-yl]ethyl)imidazolidine-2,4-dione
Escherichia coli
pH not specified in the publication, 30°C
0.0006
5-methyl-5-(2-oxo-2-[4-[4-(phenylethynyl)phenyl]piperidin-1-yl]ethyl)imidazolidine-2,4-dione
Escherichia coli
pH not specified in the publication, 30°C
0.00000048
6-(1H-benzimidazol-1-yl)-N-hydroxy-5-[4-([6-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl]ethynyl)phenyl]pyridine-3-carboxamide
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.4
N'-formyl-3-(4-methoxyphenyl)-4,5-dihydroisoxazole-5-carbohydrazide
Escherichia coli
-
pH 6.0, 30°C
0.12
N-(((2R,3R,4S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)-2-((Z)-2,3,4-trihydroxybenzylideneaminooxy)acetamide
Escherichia coli
-
-
0.0129 - 0.013
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-1H-indazole-3-carboxamide
0.00154
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-(trifluoromethoxy)benzamide
Pseudomonas aeruginosa
-
-
0.000026
N-hydroxy-1,1-dioxo-4-[4-(phenylethynyl)benzamido]-1lambda6-thiane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0634
N-hydroxy-1-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzoyl]-D-prolinamide
Escherichia coli
-
37°C, pH 6.0
0.0456
N-hydroxy-1-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzoyl]-L-prolinamide
Escherichia coli
-
37°C, pH 6.0
0.0452
N-hydroxy-1-[4-([4-[(thiomorpholin-4-yl)methyl]phenyl]ethynyl)benzoyl]-L-prolinamide
Escherichia coli
-
37°C, pH 6.0
0.0105
N-hydroxy-1-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]methyl]-L-prolinamide
Escherichia coli
-
37°C, pH 6.0
0.0081
N-hydroxy-1-[[4-([4-[(thiomorpholin-4-yl)methyl]phenyl]ethynyl)phenyl]methyl]-L-prolinamide
Escherichia coli
-
37°C, pH 6.0
0.0055 - 0.00562
N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydrooxazole-4-carboxamide
0.006 - 0.00603
N-hydroxy-2-(3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
0.0025 - 0.00251
N-hydroxy-2-(3-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
0.0005 - 0.000501
N-hydroxy-2-(3-propyl-4,5-bis(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
0.00028 - 0.000282
N-hydroxy-2-(4'-propylbiphenyl-4-yl)-4,5-dihydrooxazole-4-carboxamide
0.00056 - 0.000562
N-hydroxy-2-(4-((3-nitrophenoxy)methyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
0.00019
N-hydroxy-2-(4-(3-methylbut-2-enyloxy)-3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.001
N-hydroxy-2-(4-(3-nitrobenzyloxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.005 - 0.00501
N-hydroxy-2-(4-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
0.0217
N-hydroxy-2-(4-(trifluoromethoxy)phenyl)-4,5-dihydrothiazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0078 - 0.00794
N-hydroxy-2-(4-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
0.0055
N-hydroxy-2-(4-iodophenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00016
N-hydroxy-2-(4-methoxy-3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0178
N-hydroxy-2-(4-methoxy-3-propyl-5-(trifluoromethoxy)phenyl)-4,5-dihydrothiazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0054
N-hydroxy-2-(4-nitrophenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.01
N-hydroxy-2-(6-(trifluoromethyl)pyridin-3-yl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.02 - 0.0204
N-hydroxy-2-p-tolyl-4,5-dihydrooxazole-4-carboxamide
0.0385 - 0.0389
N-hydroxy-2-p-tolyl-4,5-dihydrothiazole-4-carboxamide
31.6
N-hydroxy-2-[(1R)-2-hydroxy-1-[4-(phenylethynyl)phenyl]ethoxy]acetamide
Escherichia coli
pH not specified in the publication, 30°C
198
N-hydroxy-2-[(1R)-2-hydroxy-1-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]ethoxy]acetamide
Escherichia coli
pH not specified in the publication, 30°C
0.48
N-hydroxy-2-[(1S)-2-hydroxy-1-[4-(phenylethynyl)phenyl]ethoxy]acetamide
Escherichia coli
pH not specified in the publication, 30°C
0.69
N-hydroxy-2-[(1S)-2-hydroxy-1-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]ethoxy]acetamide
Escherichia coli
pH not specified in the publication, 30°C
0.0217
N-hydroxy-2-[4-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-thiazole-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
10.5
N-hydroxy-2-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]methoxy]acetamide
Escherichia coli
pH not specified in the publication, 30°C
0.0000075
N-hydroxy-4-([4-[(4-[[4-(propan-2-yl)piperazin-1-yl]methyl]phenyl)ethynyl]phenoxy]methyl)oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000002
N-hydroxy-4-([[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]sulfanyl]methyl)oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000086
N-hydroxy-4-methoxy-1-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenoxy]methyl]cyclohexane-1-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000092
N-hydroxy-4-[(4-phenoxyphenoxy)methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000002
N-hydroxy-4-[(4-[[4-([4-[2-(1H-imidazol-1-yl)ethyl]piperazin-1-yl]methyl)phenyl]ethynyl]phenoxy)methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000017
N-hydroxy-4-[(4-[[4-([4-[2-(morpholin-4-yl)-2-oxoethyl]piperazin-1-yl]methyl)phenyl]ethynyl]phenoxy)methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000027
N-hydroxy-4-[(4-[[4-([4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl]methyl)phenyl]ethynyl]phenoxy)methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00001
N-hydroxy-4-[(4-[[4-([[(4-methoxyphenyl)methyl]amino]methyl)phenyl]ethynyl]phenoxy)methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000334
N-hydroxy-4-[4-(phenylethynyl)benzamido]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.011
N-hydroxy-4-[4-(phenylethynyl)benzamido]piperidine-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000296
N-hydroxy-4-[4-(phenylethynyl)benzamido]thiane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000033
N-hydroxy-4-[[4-(4-phenylbuta-1,3-diyn-1-yl)phenoxy]methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000139
N-hydroxy-4-[[4-(5-hydroxy-5-methylhexa-1,3-diyn-1-yl)phenoxy]methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000061
N-hydroxy-4-[[4-([4-[(4-methylpiperazin-1-yl)methyl]phenyl]ethynyl)phenoxy]methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000031 - 0.0000825
N-hydroxy-4-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzene-1-sulfinyl]methyl]oxane-4-carboxamide
0.0000044
N-hydroxy-4-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenoxy]methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00000064
N-hydroxy-6-(1H-imidazol-1-yl)-5-[4-([6-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl]ethynyl)phenyl]pyridine-3-carboxamide
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.0012689
N-hydroxy-N2-([2-[4-(phenylethynyl)phenyl]ethyl]carbamoyl)-L-threoninamide
Escherichia coli
pH not specified in the publication, 30°C
0.0002014
N-hydroxy-N2-([[4-(phenylethynyl)phenyl]methyl]carbamoyl)-L-threoninamide
Escherichia coli
pH not specified in the publication, 30°C
0.000035
N-hydroxy-Nalpha-[4-(phenylethynyl)benzoyl]-L-histidinamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00008
N-[(1R)-2-(hydroxyamino)-2-oxo-1-phenylethyl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000074
N-[(1S)-2-(hydroxyamino)-2-oxo-1-phenylethyl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000073
N-[(2R)-1-(hydroxyamino)-3-(methanesulfonyl)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000098
N-[(2R)-1-(hydroxyamino)-3-(methylsulfanyl)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.013
N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-1H-indazole-3-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000187
N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00154
N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-4-(trifluoromethoxy)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0075
N-[(2R)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-4-[(prop-2-en-1-yl)oxy]-3-(trifluoromethoxy)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000028
N-[(2S)-3-amino-1-(hydroxyamino)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0001631
N-[(2S)-3-amino-1-(hydroxyamino)-1-oxopropan-2-yl]-4-[4-(phenylethynyl)phenyl]piperidine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.0000053
N-[(2S)-3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000003
N-[(2S)-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.000006
N-[(2S,3R)-3-amino-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.0001464
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-3-[3-(phenylethynyl)phenyl]pyrrolidine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.0003867
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-3-[4-(phenylethynyl)phenyl]piperidine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.000036
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-3-[4-(phenylethynyl)phenyl]pyrrolidine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.00006
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-((4-[(morpholin-4-yl)methyl]phenyl)ethynyl)benzamide
Escherichia coli
-
pH 6.0, 37°C
0.000012
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-(4-[[4-(hydroxymethyl)phenyl]ethynyl]phenyl)piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.000003
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-(4-[[4-(morpholin-4-yl)phenyl]ethynyl]phenyl)piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.0000233
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-(4-[[4-(piperazin-1-yl)phenyl]ethynyl]phenyl)piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.0000104
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-(4-[[4-(trifluoromethyl)phenyl]ethynyl]phenyl)piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.000002
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000207
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-(phenylethynyl)piperidine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.06
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzamide
Escherichia coli
pH not specified in the publication, 30°C
0.00000063
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-([6-[(morpholin-4-yl)methyl]pyridin-3-yl]ethynyl)benzamide
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.0039445
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-phenylpiperidine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.0000163
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4'-(morpholin-4-yl)[1,1'-biphenyl]-4-yl]piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.000012
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-(1,3-thiazol-5-yl)phenyl]piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.0000024
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.0000021
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperidine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.000014
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)phenyl]piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.000004
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-[(4-hydroxyphenyl)ethynyl]phenyl]piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.000136
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-[(pyrazin-2-yl)ethynyl]phenyl]piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.00001
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-[(pyridin-2-yl)ethynyl]phenyl]piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.000063
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-[(pyridin-3-yl)ethynyl]phenyl]piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.000004
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-[(pyridin-4-yl)ethynyl]phenyl]piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.000021
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-[(thiophen-2-yl)ethynyl]phenyl]piperazine-1-carboxamide
Escherichia coli
pH not specified in the publication, 30°C
0.000128
N-[1-(hydroxyamino)-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.002067
N-[1-(hydroxyamino)-2-methyl-1-oxopropan-2-yl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000071
N-[1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0081
N-[1-(hydroxycarbamoyl)cyclobutyl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0035
N-[1-(hydroxycarbamoyl)cyclohexyl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000516
N-[2-(hydroxyamino)-2-oxoethyl]-4-(phenylethynyl)benzamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000006
N-[3-amino-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperazine-1-carboxamide
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0000024
N-[3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-(phenylethynyl)benzamide
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.0000138
N-[3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperidine-1-carboxamide
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.000286
N-[3-hydroxy-1-(hydroxyamino)-2-methyl-1-oxopropan-2-yl][1,1'-biphenyl]-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000003
N-[3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-[4-(phenylethynyl)phenyl]piperazine-1-carboxamide
Escherichia coli
-
pH not specified in the publication, temperature not specified in the publication
0.000014
N1-hydroxy-N2-[4-(phenylethynyl)benzoyl]-N4-prop-2-yn-1-yl-L-aspartamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.000033
N1-hydroxy-N4-(2-methoxyethyl)-N2-[4-(phenylethynyl)benzoyl]-L-aspartamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000053
N1-hydroxy-N4-(3-hydroxypropyl)-N2-[4-(phenylethynyl)benzoyl]-L-aspartamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.004
[3-(4-methoxyphenyl)-4,5-dihydro-isoxazol-5-yl]phosphonic acid
Escherichia coli
-
pH 6.0, 30°C
additional information
(R)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methoxy-3-propyl-5-(trifluoromethoxy)benzamide
0.000001
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Klebsiella pneumoniae
-
pH 7.4, 37°C
0.00000137
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000014
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
-
wild-type, pH 7.4, 37°C
0.0000079
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
-
mutant M62R, pH 7.4, 37°C
0.000041
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Acinetobacter baumannii
-
pH 7.4, 37°C
0.000000069
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Klebsiella pneumoniae
-
pH 7.4, 37°C
0.0000011
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000011
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
-
wild-type, pH 7.4, 37°C
0.0000021
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Pseudomonas aeruginosa
-
mutant M62R, pH 7.4, 37°C
0.000183
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide
Acinetobacter baumannii
-
pH 7.4, 37°C
0.00000068
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
Klebsiella pneumoniae
-
pH 7.4, 37°C
0.0000028
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
Pseudomonas aeruginosa
-
mutant M62R, pH 7.4, 37°C
0.0000036
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000036
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
Pseudomonas aeruginosa
-
wild-type, pH 7.4, 37°C
0.00011
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide
Acinetobacter baumannii
-
pH 7.4, 37°C
0.0305
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-[4-(4-phenylbuta-1,3-diyn-1-yl)phenyl]oxolane-2-carboxamide
Escherichia coli
-
pH 6.0, 37°C
0.032
(2S,3R,4S,5S)-N,3,4-trihydroxy-5-[4-(4-phenylbuta-1,3-diyn-1-yl)phenyl]oxolane-2-carboxamide
Escherichia coli
-
pH 6.0, 37°C
0.000008
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylpentanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.00016
(2S,3S)-2-[([1,1'-biphenyl]-4-yl)methoxy]-N,3-dihydroxy-2-methylpentanamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
26
(4R)-2-(3,4-dimethoxy-5-propylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Escherichia coli
-
pH 6.0, 30°C, substrate: UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine
75
(4R)-2-(3,4-dimethoxy-5-propylphenyl)-N-hydroxy-4,5-dihydro-1,3-oxazole-4-carboxamide
Escherichia coli
-
pH 6.0, 30°C, substrate: UDP3-O-(N-hexyl-propionamide)-N-acetylglucosamine
2500
(4R)-N-hydroxy-2-(4-methoxyphenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
Escherichia coli
-
pH 6.0, 30°C, substrate: UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine
2600
(4R)-N-hydroxy-2-(4-methoxyphenyl)-4,5-dihydro-1,3-oxazole-4-carboxamide
Escherichia coli
-
pH 6.0, 30°C, substrate: UDP3-O-(N-hexyl-propionamide)-N-acetylglucosamine
0.002
1,5-anhydro-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-3-O-[(3S)-3-hydroxyhexadecanoyl]-D-glucitol
Escherichia coli
pH not specified in the publication, 30°C
0.0181
1,5-anhydro-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-3-O-[(3S)-3-hydroxyhexadecanoyl]-D-glucitol
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.115
1,5-anhydro-2-deoxy-3-O-hexanoyl-2-[[hydroxy(methyl)phosphoryl]methyl]-D-glucitol
Escherichia coli
pH not specified in the publication, 30°C
0.192
1,5-anhydro-2-deoxy-3-O-hexanoyl-2-[[hydroxy(methyl)phosphoryl]methyl]-D-glucitol
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.001
2-(3-allyl-5-fluoro-4-methoxy-2-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0033
2-(3-allyl-5-fluoro-4-methoxy-2-methylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0049
2-(3-bromo-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00501
2-(3-bromo-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.009
2-(3-bromo-5-fluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00912
2-(3-bromo-5-fluoro-4-methoxyphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.03
2-(3-chloro-4-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0302
2-(3-chloro-4-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0003
2-(3-chloro-5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00159
2-(3-chloro-5-fluoro-1H-indol-2-yl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.001
2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00331
2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0468
2-(3-ethoxy-4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.025
2-(3-fluoro-5-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0251
2-(3-fluoro-5-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00025
2-(4-(3-fluorobenzyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.000251
2-(4-(3-fluorobenzyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0022
2-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00223
2-(4-(allyloxy)-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00035
2-(4-(but-3-enyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.000355
2-(4-(but-3-enyloxy)-3-(trifluoromethoxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0056
2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00562
2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0587
2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrothiazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0589
2-(4-(but-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrothiazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0049
2-(4-(dimethylamino)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00501
2-(4-(dimethylamino)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.018
2-(4-acetylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0182
2-(4-acetylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0073
2-(4-butylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.007413
2-(4-butylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0013
2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00132
2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.000955
2-(4-fluoro-3-propylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00096
2-(4-fluoro-3-propylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.006
2-(4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00603
2-(4-fluorophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0312
2-(5-fluoro-1H-indol-2-yl)-N-hydroxy-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0312
2-(5-fluoro-1H-indol-2-yl)-N-hydroxy-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0075
4-(allyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-3-(trifluoromethoxy)benzamide
Pseudomonas aeruginosa
-
-
0.00759
4-(allyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-3-(trifluoromethoxy)benzamide
Pseudomonas aeruginosa
-
-
0.0039
4-(but-3-enyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
Pseudomonas aeruginosa
-
-
0.00398
4-(but-3-enyloxy)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
Pseudomonas aeruginosa
-
-
0.0129
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-1H-indazole-3-carboxamide
Pseudomonas aeruginosa
-
-
0.013
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-1H-indazole-3-carboxamide
Pseudomonas aeruginosa
-
-
0.0055
N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00562
N-hydroxy-2-(1H-indazol-3-yl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.006
N-hydroxy-2-(3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00603
N-hydroxy-2-(3-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0025
N-hydroxy-2-(3-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00251
N-hydroxy-2-(3-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0005
N-hydroxy-2-(3-propyl-4,5-bis(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.000501
N-hydroxy-2-(3-propyl-4,5-bis(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00028
N-hydroxy-2-(4'-propylbiphenyl-4-yl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.000282
N-hydroxy-2-(4'-propylbiphenyl-4-yl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00056
N-hydroxy-2-(4-((3-nitrophenoxy)methyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.000562
N-hydroxy-2-(4-((3-nitrophenoxy)methyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.005
N-hydroxy-2-(4-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00501
N-hydroxy-2-(4-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0078
N-hydroxy-2-(4-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.00794
N-hydroxy-2-(4-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.02
N-hydroxy-2-p-tolyl-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0204
N-hydroxy-2-p-tolyl-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0385
N-hydroxy-2-p-tolyl-4,5-dihydrothiazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0389
N-hydroxy-2-p-tolyl-4,5-dihydrothiazole-4-carboxamide
Pseudomonas aeruginosa
-
-
0.0000031
N-hydroxy-4-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzene-1-sulfinyl]methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.0000825
N-hydroxy-4-[[4-([4-[(morpholin-4-yl)methyl]phenyl]ethynyl)benzene-1-sulfinyl]methyl]oxane-4-carboxamide
Pseudomonas aeruginosa
pH not specified in the publication, 30°C
0.007
Zn2+
Escherichia coli
-
40 mM Bis-Tris, pH 6 at 1°C
0.024
Zn2+
Escherichia coli
-
40 mM Bis-Tris, pH 5.5 at 30°C
additional information
(R)-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methoxy-3-propyl-5-(trifluoromethoxy)benzamide
Pseudomonas aeruginosa
-
above 50 microM
additional information
(R)-N-hydroxy-2-(4-hydroxyphenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
above 30 microM
additional information
2,3-dihydroxy-benzaldehyde O-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-oxime
Escherichia coli
-
above 500 microM
additional information
2,4-dihydroxy-benzaldehyde O-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-oxime
Escherichia coli
-
above 500 microM
additional information
2-(4-(heptyloxy)phenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
IC50 value is above 30 microM
additional information
2-(4-acetamidophenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
IC50 value is above 30 microM
additional information
3,4,5-trihydroxy-benzaldehyde O-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-oxime
Escherichia coli
-
above 500 microM
additional information
4-fluoro-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
Pseudomonas aeruginosa
-
IC50 value is above 50 microM
additional information
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methoxy-3-propyl-5-(trifluoromethoxy)benzamide
Pseudomonas aeruginosa
-
IC50 value is above 50 microM
additional information
N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methylbenzamide
Pseudomonas aeruginosa
-
IC50 value is above 50 microM
additional information
N-hydroxy-2-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
IC50 value is above 30 microM
additional information
N-hydroxy-2-(2-(trifluoromethoxy)phenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
IC50 value is above 10 microM
additional information
N-hydroxy-2-(4-hydroxyphenyl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
IC50 value is above 30 microM
additional information
N-hydroxy-2-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydrooxazole-4-carboxamide
Pseudomonas aeruginosa
-
IC50 value is above 30 microM
additional information
N-hydroxy-2-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydrothiazole-4-carboxamide
Pseudomonas aeruginosa
-
IC50 value is above 60 microM
additional information
N-hydroxy-2-p-tolyl-5,6-dihydro-4H-1,3-oxazine-4-carboxamide
Pseudomonas aeruginosa
-
IC50 value is above 50 microM
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Sorensen, P.G.; Lutkenhaus, J.; Young, K.; Eveland, S.S.; Anderson, M.S.; Raetz, C.R.H.
Regulation of UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase in Escherichia coli. The second enzymic step of lipid A biosynthesis
J. Biol. Chem.
271
25898-25905
1996
Escherichia coli
brenda
Fuehrer, F.; Mueller, A.; Baumann, H.; Langklotz, S.; Kutscher, B.; Narberhaus, F.
Sequence and length recognition of the C-terminal turnover element of LpxC, a soluble substrate of the membrane-bound FtsH protease
J. Mol. Biol.
372
485-496
2007
Escherichia coli
brenda
Fuehrer, F.; Langklotz, S.; Narberhaus, F.
The C-terminal end of LpxC is required for degradation by the FtsH protease
Mol. Microbiol.
59
1025-1036
2006
Escherichia coli
brenda
Buetow, L.; Dawson, A.; Hunter, W.N.
The nucleotide-binding site of Aquifex aeolicus LpxC
Acta Crystallogr. Sect. F
62
1082-1086
2006
Aquifex aeolicus (O67648), Aquifex aeolicus
brenda
Wang, W.; Maniar, M.; Jain, R.; Jacobs, J.; Trias, J.; Yuan, Z.
A fluorescence-based homogeneous assay for measuring activity of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase
Anal. Biochem.
290
338-346
2001
Escherichia coli
brenda
Clements, J.M.; Coignard, F.; Johnson, I.; Chandler, S.; Palan, S.; Waller, A.; Wijkmans, J.; Hunter, M.G.
Antibacterial activities and characterization of novel inhibitors of LpxC
Antimicrob. Agents Chemother.
46
1793-1799
2002
Escherichia coli, Escherichia coli D22
brenda
Mdluli, K.E.; Witte, P.R.; Kline, T.; Barb, A.W.; Erwin, A.L.; Mansfield, B.E.; McClerren, A.L.; Pirrung, M.C.; Tumey, L.N.; Warrener, P.; Raetz, C.R.; Stover, C.K.
Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa
Antimicrob. Agents Chemother.
50
2178-2184
2006
Escherichia coli, Pseudomonas aeruginosa
brenda
Anderson, M.S.; Robertson, A.D.; Macher, I.; Raetz, C.R.
Biosynthesis of lipid A in Escherichia coli: identification of UDP-3-O-[(R)-3-hydroxymyristoyl]-alpha-D-glucosamine as a precursor of UDP-N2,O3-bis[(R)-3-hydroxymyristoyl]-alpha-D-glucosamine
Biochemistry
27
1908-1917
1988
Escherichia coli
brenda
Jackman, J.E.; Raetz, C.R.; Fierke, C.A.
UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme
Biochemistry
38
1902-1911
1999
Escherichia coli
brenda
Jackman, J.E.; Raetz, C.R.; Fierke, C.A.
Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site
Biochemistry
40
514-523
2001
Aquifex aeolicus, Escherichia coli
brenda
Coggins, B.E.; McClerren, A.L.; Jiang, L.; Li, X.; Rudolph, J.; Hindsgaul, O.; Raetz, C.R.; Zhou, P.
Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design
Biochemistry
44
1114-1126
2005
Aquifex aeolicus (O67648), Aquifex aeolicus
brenda
McClerren, A.L.; Endsley, S.; Bowman, J.L.; Andersen, N.H.; Guan, Z.; Rudolph, J.; Raetz, C.R.
A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin
Biochemistry
44
16574-16583
2005
Aquifex aeolicus, Escherichia coli, Escherichia coli R477
brenda
Hernick, M.; Fierke, C.A.
Molecular recognition by Escherichia coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase is modulated by bound metal ions
Biochemistry
45
14573-14581
2006
Escherichia coli
brenda
Hernick, M.; Fierke, C.A.
Catalytic mechanism and molecular recognition of E. coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase probed by mutagenesis
Biochemistry
45
15240-15248
2006
Escherichia coli
brenda
Gennadios, H.A.; Whittington, D.A.; Li, X.; Fierke, C.A.; Christianson, D.W.
Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase
Biochemistry
45
7940-7948
2006
Aquifex aeolicus (O67648)
brenda
Barb, A.W.; Leavy, T.M.; Robins, L.I.; Guan, Z.; Six, D.A.; Zhou, P.; Hangauer, M.J.; Bertozzi, C.R.; Raetz, C.R.
Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC
Biochemistry
48
3068-3077
2009
Escherichia coli, Helicobacter pylori, Rhizobium leguminosarum
brenda
Kadam, R.U.; Roy, N.
Cluster analysis and two-dimensional quantitative structure-activity relationship (2D-QSAR) of Pseudomonas aeruginosa deacetylase LpxC inhibitors
Bioorg. Med. Chem. Lett.
16
5136-5143
2006
Pseudomonas aeruginosa
brenda
Kadam, R.U.; Chavan, A.; Roy, N.
Pharmacophoric features of Pseudomonas aeruginosa deacetylase LpxC inhibitors: an electronic and structural analysis
Bioorg. Med. Chem. Lett.
17
861-868
2007
Pseudomonas aeruginosa
brenda
Shin, H.; Gennadios, H.A.; Whittington, D.A.; Christianson, D.W.
Amphipathic benzoic acid derivatives: synthesis and binding in the hydrophobic tunnel of the zinc deacetylase LpxC
Bioorg. Med. Chem.
15
2617-2623
2007
Aquifex aeolicus (O67648)
brenda
Kadam, R.U.; Garg, D.; Roy, N.
Selective mapping of chemical space for Pseudomonas aeruginosa deacetylase LpxC inhibitory potential
Chem. Biol. Drug Des.
71
45-56
2008
Pseudomonas aeruginosa
brenda
Pirrung, M.C.; Tumey, L.N.; McClerren, A.L.; Raetz, C.R.
High-throughput catch-and-release synthesis of oxazoline hydroxamates. Structure-activity relationships in novel inhibitors of Escherichia coli LpxC: in vitro enzyme inhibition and antibacterial properties
J. Am. Chem. Soc.
125
1575-1586
2003
Escherichia coli
brenda
Hyland, S.A.; Eveland, S.S.; Anderson, M.S.
Cloning, expression, and purification of UDP-3-O-acyl-GlcNAc deacetylase from Pseudomonas aeruginosa: a metalloamidase of the lipid A biosynthesis pathway
J. Bacteriol.
179
2029-2037
1997
Escherichia coli, Pseudomonas aeruginosa (P47205), Pseudomonas aeruginosa
brenda
Young, K.; Silver, L.L.; Bramhill, D.; Cameron, P.; Eveland, S.S.; Raetz, C.R.; Hyland, S.A.; Anderson, M.S.
The envA permeability/cell division gene of Escherichia coli encodes the second enzyme of lipid A biosynthesis. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase
J. Biol. Chem.
270
30384-30391
1995
Escherichia coli
brenda
Hernick, M.; Gennadios, H.A.; Whittington, D.A.; Rusche, K.M.; Christianson, D.W.; Fierke, C.A.
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism
J. Biol. Chem.
280
16969-16978
2005
Escherichia coli, Aquifex aeolicus (O67848), Aquifex aeolicus
brenda
Langsdorf, E.F.; Malikzay, A.; Lamarr, W.A.; Daubaras, D.; Kravec, C.; Zhang, R.; Hart, R.; Monsma, F.; Black, T.; Ozbal, C.C.; Miesel, L.; Lunn, C.A.
Screening for antibacterial inhibitors of the UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) using a high-throughput mass spectrometry assay
J. Biomol. Screen.
15
52-61
2009
Escherichia coli
brenda
Kadam, R.U.; Garg, D.; Chavan, A.; Roy, N.
Evaluation of Pseudomonas aeruginosa deacetylase LpxC inhibitory activity of dual PDE4-TNFr inhibitors: a multiscreening approach
J. Chem. Inf. Model.
47
1188-1195
2007
Pseudomonas aeruginosa
brenda
Kadam, R.U.; Shivange, A.V.; Roy, N.
Escherichia coli versus Pseudomonas aeruginosa deacetylase LpxC inhibitors selectivity: surface and cavity-depth-based analysis
J. Chem. Inf. Model.
47
1215-1224
2007
Escherichia coli, Pseudomonas aeruginosa (P47205), Pseudomonas aeruginosa
brenda
Kline, T.; Andersen, N.H.; Harwood, E.A.; Bowman, J.; Malanda, A.; Endsley, S.; Erwin, A.L.; Doyle, M.; Fong, S.; Harris, A.L.; Mendelsohn, B.; Mdluli, K.; Raetz, C.R.; Stover, C.K.; Witte, P.R.; Yabannavar, A.; Zhu, S.
Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC
J. Med. Chem.
45
3112-3129
2002
Pseudomonas aeruginosa
brenda
Pirrung, M.C.; Tumey, L.N.; Raetz, C.R.; Jackman, J.E.; Snehalatha, K.; McClerren, A.L.; Fierke, C.A.; Gantt, S.L.; Rusche, K.M.
Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups
J. Med. Chem.
45
4359-4370
2002
Escherichia coli
brenda
Robinet, J.J.; Gauld, J.W.
DFT investigation on the mechanism of the deacetylation reaction catalyzed by LpxC
J. Phys. Chem. B
112
3462-3469
2008
Aquifex aeolicus
brenda
Coggins, B.E.; Li, X.; McClerren, A.L.; Hindsgaul, O.; Raetz, C.R.; Zhou, P.
Structure of the LpxC deacetylase with a bound substrate-analog inhibitor
Nat. Struct. Biol.
10
645-651
2003
Aquifex aeolicus
brenda
Whittington, D.A.; Rusche, K.M.; Shin, H.; Fierke, C.A.; Christianson, D.W.
Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis
Proc. Natl. Acad. Sci. USA
100
8146-8150
2003
Aquifex aeolicus (O67648), Aquifex aeolicus
brenda
Barb, A.W.; Jiang, L.; Raetz, C.R.; Zhou, P.
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding
Proc. Natl. Acad. Sci. USA
104
18433-18438
2007
Escherichia coli, Aquifex aeolicus (O67648), Rhizobium leguminosarum (Q1ME43)
brenda
Mochalkin, I.; Knafels, J.D.; Lightle, S.
Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor.
Protein Sci.
17
450-457
2008
Pseudomonas aeruginosa (P47205), Pseudomonas aeruginosa
brenda
Ko, Y.; Chen, C.; Shieh, C.; Liu, Y.
Simultaneous purification and immobilization of D-hydantoinase on the immobilized metal affinity membrane via coordination bonds
Biochem. Eng. J.
61
20-27
2012
Escherichia coli
-
brenda
Hernick, M.; Gattis, S.G.; Penner-Hahn, J.E.; Fierke, C.A.
Activation of Escherichia coli UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase by Fe2+ yields a more efficient enzyme with altered ligand affinity
Biochemistry
49
2246-2255
2010
Escherichia coli
brenda
Mansoor, U.F.; Vitharana, D.; Reddy, P.A.; Daubaras, D.L.; McNicholas, P.; Orth, P.; Black, T.; Siddiqui, M.A.
Design and synthesis of potent Gram-negative specific LpxC inhibitors
Bioorg. Med. Chem. Lett.
21
1155-1161
2011
Escherichia coli
brenda
Gattis, S.G.; Hernick, M.; Fierke, C.A.
Active site metal ion in UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) switches between Fe(II) and Zn(II) depending on cellular conditions
J. Biol. Chem.
285
33788-33796
2010
Escherichia coli
brenda
Murphy-Benenato, K.; Olivier, N.; Choy, A.; Ross, P.; Miller, M.; Thresher, J.; Gao, N.; Hale, M.
Synthesis, structure, and SAR of tetrahydropyran-based LpxC inhibitors
ACS Med. Chem. Lett.
5
1213-1218A
2014
Escherichia coli, Pseudomonas aeruginosa, Aquifex aeolicus (O67648), Aquifex aeolicus, Escherichia coli W3110 / ATCC 27325
brenda
Clayton, G.M.; Klein, D.J.; Rickert, K.W.; Patel, S.B.; Kornienko, M.; Zugay-Murphy, J.; Reid, J.C.; Tummala, S.; Sharma, S.; Singh, S.B.; Miesel, L.; Lumb, K.J.; Soisson, S.M.
Structure of the bacterial deacetylase LpxC bound to the nucleotide reaction product reveals mechanisms of oxyanion stabilization and proton transfer
J. Biol. Chem.
288
34073-34080
2013
Escherichia coli
brenda
Tomaras, A.; McPherson, C.; Kuhn, M.; Carif, A.; Mullins, L.; George, D.; Desbonnet, C.; Eidem, T.; Montgomery, J.; Brown, M.; Reilly, U.; Miller, A.; O'Donnell, J.
LpxC Inhibitors as new antibacterial agents and tools for studying regulation of lipid a biosynthesis in Gram-negative pathogens
mBio
5
e01551-14
2014
Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa
brenda
Gao, N.; McLeod, S.; Hajec, L.; Olivier, N.; Lahiri, S.; Prince, D.; Thresher, J.; Ross, P.; Whiteaker, J.; Doig, P.; Li, A.; Hill, P.; Cornebise, M.; Reck, F.; Hale, M.
Overexpression of Pseudomonas aeruginosa LpxC with its inhibitors in an acrB-deficient Escherichia coli strain
Protein Expr. Purif.
104
57-64
2014
Pseudomonas aeruginosa (P47205), Pseudomonas aeruginosa
brenda
Jana, S.; Loeppenberg, M.; Daniliuc, C.; Jose, J.; Holl, R.
Development of novel LpxC inhibitors: chiral-pool synthesis of C-triazolyl glycosides
Tetrahedron
69
9434-9442
2013
Escherichia coli
-
brenda
Jana, S.; Loeppenberg, M.; Daniliuc, C.; Holl, R.
C-Triazolyl beta-D-furanosides as LpxC inhibitors: stereoselective synthesis and biological valuation
Tetrahedron
70
6569-6577
2014
Escherichia coli
-
brenda
Jana, S.; Loeppenberg, M.; Daniliuc, C.; Holl, R.
Synthesis and biological evaluation of C-ethynyl furanosides as LpxC inhibitors
Tetrahedron
71
956-966
2015
Escherichia coli
-
brenda
Kalinin, D.V.; Agoglitta, O.; Van de Vyver, H.; Melesina, J.; Wagner, S.; Riemann, B.; Schaefers, M.; Sippl, W.; Loeffler, B.; Holl, R.
Proline-based hydroxamates targeting the zinc-dependent deacetylase LpxC Synthesis, antibacterial properties, and docking studies
Bioorg. Med. Chem.
27
1997-2018
2019
Escherichia coli
brenda
Kalinin, D.V.; Holl, R.
Insights into the zinc-dependent deacetylase LpxC biochemical properties and inhibitor design
Curr. Top. Med. Chem.
16
2379-2430
2016
Aquifex aeolicus (O67648), Escherichia coli (P0A727), Pseudomonas aeruginosa (P47205), Pseudomonas aeruginosa ATCC 15692 (P47205)
brenda
Piizzi, G.; Parker, D.T.; Peng, Y.; Dobler, M.; Patnaik, A.; Wattanasin, S.; Liu, E.; Lenoir, F.; Nunez, J.; Kerrigan, J.; McKenney, D.; Osborne, C.; Yu, D.; Lanieri, L.; Bojkovic, J.; Dzink-Fox, J.; Lilly, M.D.; Sprague, E.R.; Lu, Y.; Wang, H.; Ranjitkar, S.; Xie, L.; Wang, B.; Glick, M.; Hamann, L.G.
Design, synthesis, and properties of a potent inhibitor of Pseudomonas aeruginosa deacetylase LpxC
J. Med. Chem.
60
5002-5014
2017
Pseudomonas aeruginosa
brenda
Miller, M.; Gao, N.; Ross, P.; Olivier, N.
Crystal structure of A. aeolicus LpxC with bound product suggests alternate deacetylation mechanism
Proteins
83
1706-1719
2015
Aquifex aeolicus (O67648), Aquifex aeolicus
brenda
Emiola, A.; Andrews, S.; Heller, C.; George, J.
Crosstalk between the lipopolysaccharide and phospholipid pathways during outer membrane biogenesis in Escherichia coli
Proc. Natl. Acad. Sci. USA
113
3108-3113
2016
Escherichia coli (P0A725), Escherichia coli, Escherichia coli K12 (P0A725)
brenda