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IUBMB CommentsThe reaction is involved in the aerobic catabolism of nicotinic acid.
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
n-formylmaleamate deformylase,
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N-formylmaleamic acid + H2O = maleamate + formate
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N-formylmaleamic acid amidohydrolase
The reaction is involved in the aerobic catabolism of nicotinic acid.
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N-formylmaleamic acid + H2O
maleamate + formate
N-formylmaleamic acid + H2O
maleamate + formate
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aerobic catabolism of nicotinic acid
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N-formylmaleamic acid + H2O
maleamate + formate
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S101, D125, and H245 are essential for the enzyme activity, constituting the catalytic triad of the NicD deformylase
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N-formylmaleamic acid + H2O
maleamate + formate
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aerobic catabolism of nicotinic acid
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brenda
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brenda
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29000
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x * 29000, SDS-PAGE
29100
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x * 29100, calculated from sequence
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x * 29000, SDS-PAGE
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x * 29100, calculated from sequence
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x * 29000, SDS-PAGE
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x * 29100, calculated from sequence
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D125A
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mutation leads to a complete loss of the deformylase activity
E221A
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70% of wild-type deformylase acticity
H245A
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mutation leads to a complete loss of the deformylase activity
S101A
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mutation leads to a complete loss of the deformylase activity
D125A
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mutation leads to a complete loss of the deformylase activity
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E221A
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70% of wild-type deformylase acticity
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H245A
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mutation leads to a complete loss of the deformylase activity
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S101A
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mutation leads to a complete loss of the deformylase activity
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expression in Escherichia coli
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Jimenez, J.; Canales, A.; Jimenez-Barbero, J.; Ginalski, K.; Rychlewski, L.; Garcia, J.; Diaz, E.
Deciphering the genetic determinants for aerobic nicotinic acid degradation: The nic cluster from Pseudomonas putida KT2440
Proc. Natl. Acad. Sci. USA
105
11329-11334
2008
Pseudomonas putida, Pseudomonas putida KT 2240
brenda
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