Hydrolysis of O-sialoglycoproteins; cleaves -Arg31-/-Asp- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated
Synonyms
glycoprotease, o-sialoglycoprotein endopeptidase, sialoglycoprotease, glycoproteinase, pg0778, more
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Hydrolysis of O-sialoglycoproteins; cleaves -Arg31-/-Asp- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated
no activity with glycoproteins which contain N-linked glycans but no O-sialo-glycans, leukocyte integrins, transferrin receptor, HLA class I and 8A3 Ag
no activity with glycoproteins which contain N-linked glycans but no O-sialo-glycans, leukocyte integrins, transferrin receptor, HLA class I and 8A3 Ag
increases alpha-CD3-induced Ca2+ responses in CD4+ T cells, and enhances cytokine production by CD4+ T cells, of both young and old mice, treatment with OSGE can enhance the expression of early activation markers in both WT and CD43 KO mice, overview
Gcp is required for growth and is essential for bacteria, the essential Gcp is involved in the modification of substrates of murein hydrolases as well as in the regulation of expression and/or activity of some murein hydrolases, which, in turn, may play important roles in bacterial viability, Gcp may function independently from several key autolysins, e.g. Atl, LytM, and LytN, and regulators, e.g. ArlRS, Mgr/Rat, and CidA, overview
increases alpha-CD3-induced Ca2+ responses in CD4+ T cells, and enhances cytokine production by CD4+ T cells, of both young and old mice, treatment with OSGE can enhance the expression of early activation markers in both WT and CD43 KO mice, overview
Gcp is required for growth and is essential for bacteria, the essential Gcp is involved in the modification of substrates of murein hydrolases as well as in the regulation of expression and/or activity of some murein hydrolases, which, in turn, may play important roles in bacterial viability, Gcp may function independently from several key autolysins, e.g. Atl, LytM, and LytN, and regulators, e.g. ArlRS, Mgr/Rat, and CidA, overview
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Carcinoma
Cleavage of epitectin, a mucin-type sialoglycoprotein, from the surface of human laryngeal carcinoma cells by a glycoprotease from Pasteurella haemolytica.
Cleavage of epitectin, a mucin-type sialoglycoprotein, from the surface of human laryngeal carcinoma cells by a glycoprotease from Pasteurella haemolytica.
Cleavage of epitectin, a mucin-type sialoglycoprotein, from the surface of human laryngeal carcinoma cells by a glycoprotease from Pasteurella haemolytica.
GPIbalpha-clustering activates caspase-9 activation and phosphatidylserine surface expression. This is opposed by O-sialoglycoprotein endopeptidase treatment
construction of a spacp-regulated gcp expression strain and a TetR-regulated gcp antisense expression strain, the down-regulation of gcp expression can effectively inhibit Triton X-100-induced lysis, eliminate penicillin- and vancomycin-caused cell lysis, and dramatically increase tolerance to hydrolases, overview
The detection of the sialoglycoprotease gene and assay for sialoglycoprotease activity among isolates of Pasteurella haemolytica A1 strains, serotypes A13, A14, T15 and A16