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Information on EC 3.4.23.B13 - proteinase P15
for references in articles please use BRENDA:EC3.4.23.B13preliminary BRENDA-supplied EC number
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EC Tree
3.4.23.B13 proteinase P15Specify your search results
Word Map
- 3.4.23.B13
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inflammasome
- caspase-1
- lipopolysaccharide
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pyroptosis
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noncanonical
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casp11
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caspase-11-dependent
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nod-like
- wedelolactone
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guanylate-binding
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endotoxic
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caspase-11-deficient
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gsdmd
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legionella
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rodentium
The expected taxonomic range for this enzyme is: Avian myeloblastosis-associated virus
Reaction Schemes
efficient cleavage of Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala, no cleavage with Ser, Arg or Glu at P1, Gly or Phe at P2, and Pro at P3. Specifically liberates the five major structural proteins from the common gag precursor, as well as reverse transcriptase and integrase from the gag-pol precursor
Synonyms
mav-pr, p15gag proteinase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
15gag proteinase
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MAV-PR
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myeloblastosis associated virus proteinase
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p15gag proteinase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
efficient cleavage of Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala, no cleavage with Ser, Arg or Glu at P1, Gly or Phe at P2, and Pro at P3. Specifically liberates the five major structural proteins from the common gag precursor, as well as reverse transcriptase and integrase from the gag-pol precursor
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
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CAS REGISTRY NUMBER
COMMENTARY
71892-49-4
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Ala-Ser-Ala-Pro-Pro-Pro-Pro-Tyr-Val-Gly-Ser-Gly-Leu-Tyr-Pro-Ser + H2O
Ala-Ser-Ala-Pro-Pro-Pro-Pro-Tyr-Val-Gly + Ser-Gly-Leu-Tyr-Pro-Ser
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50%of the activity with Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
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-
?
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Arg-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Asn-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Asn-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Asp-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Ala-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Ile-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Leu-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Gln-Val-Leu-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Leu + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Val-Met-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Met + Phe(NO2)-Val-Arg-Lys-Ala
75.3% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Val-Met-Pro-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Met + Pro-Val-Arg-Lys-Ala
52% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Phe + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Gln-Val-Ser-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Ser + Phe(NO2)-Val-Arg-Lys-Ala
9.4% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Gln-His-Thr + H2O
Ala-Thr-His-Gln-Val-Tyr + Phe(NO2)-Val-Gln-His-Thr
54.2% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Glu-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Met-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Met-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
71.5% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Tyr-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Val-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Val-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-Phe-Gln-Ala-Phe(NO2)-Pro-Leu-Arg + H2O
Ala-Thr-Phe-Gln-Ala-Phe(NO2) + Pro-Leu-Arg
6% of the activity with Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-Phe-Gln-Ala-Phe(NO2)-Pro-Leu-Arg-Glu + H2O
Ala-Thr-Phe-Gln-Ala-Phe(NO2) + Pro-Leu-Arg-Glu
14% of the activity with Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-Phe-Gln-Ala-Phe(NO2)-Pro-Leu-Arg-Glu-Ala + H2O
Ala-Thr-Phe-Gln-Ala-Phe(NO2) + Pro-Leu-Arg-Glu-Ala
6.3% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-Phe-Gln-Ala-Tyr-Phe(NO2)-Ala-Gln-Phe-Thr + H2O
Ala-Thr-Phe-Gln-Ala-Tyr + Phe(NO2)-Ala-Gln-Phe-Thr
12.9% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-Phe-Gln-Ala-Tyr-Pro-Ala-Gln-Phe-Thr + H2O
Ala-Thr-Phe-Gln-Ala-Tyr + Pro-Ala-Gln-Phe-Thr
88.5% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-Pro-Cys-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-Pro-Cys-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-Pro-Gln-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Cys-Glu-Val-Thr-Gly-Val-Arg-Ala-Asp-Val-His-Leu-Leu-Glu-Gln-Pro + H2O
Cys-Glu-Val-Thr-Gly-Val-Arg-Ala + Asp-Val-His-Leu-Leu-Glu-Gln-Pro
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35% of the activity with Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
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?
Gly-Pro-Glu-Pro-Pro-Ala-Val-Ser-Leu-Ala-Met-Thr-Met-Glu-His-Lys + H2O
Gly-Pro-Glu-Pro-Pro-Ala-Val-Ser + Leu-Ala-Met-Thr-Met-Glu-His-Lys
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80%of the activity with Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
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?
Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro + H2O
Gly-Pro-Val-Val-Phe(NO2) + Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
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?
HIV-1 polyprotein + H2O
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cleavage of the HIV-1 polyprotein only at concentrations above 0.001 mM. Cleavage products are very similar or identical to that of HIV-1 protease
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?
Leu-Glu-Lys-Ser-His-Cys-Ile-Ala-Glu-Val-Glu-Lys-Asp-Ala-Ile-Pro + H2O
Leu-Glu-Lys-Ser-His-Cys-Ile-Ala + Glu-Val-Glu-Lys-Asp-Ala-Ile-Pro
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50%of the activity with Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
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?
Phe-Gln-Ala-Phe(NO2)-Pro-Leu-Arg-Glu-Ala-Val + H2O
Phe-Gln-Ala-Phe(NO2) + Pro-Leu-Arg-Glu-Ala-Val
20% of the activity with Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ser-Gln-Ala-Thr-Phe-Gln-Ala-Tyr-Pro-Leu-Arg-Glu-Ala-Val-Ile-Leu + H2O
Ser-Gln-Ala-Thr-Phe-Gln-Ala-Tyr + Pro-Leu-Arg-Glu-Ala-Val-Ile-Leu
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90%of the activity with Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
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?
Ser-Gln-Ala-Thr-Phe-Gln-Ala-Tyr-Pro-Leu-Arg-Glu-Ala-Val-Ile-Leu-Lys + H2O
Ser-Gln-Ala-Thr-Phe-Gln-Ala-Tyr + Pro-Leu-Arg-Glu-Ala-Val-Ile-Leu-Lys
6% of the activity with Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Thr-Gly-Pro-Pro-Val-Val-Ala-Met-Pro-Val-val-Ile-Lys-Thr-Glu-Gly + H2O
Thr-Gly-Pro-Pro-Val-Val-Ala-Met + Pro-Val-Val-Ile-Lys-Thr-Glu-Gly
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10%of the activity with Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
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?
Thr-Phe-Gln-Ala-Phe(NO2)-Pro-Leu-Arg-Glu-Ala-Val + H2O
Thr-Phe-Gln-Ala-Phe(NO2) + Pro-Leu-Arg-Glu-Ala-Val
Thr-Phe-Gln-Ala-Tyr-Pro-Leu-Arg-Glu-Ala + H2O
Thr-Phe-Gln-Ala-Tyr + Pro-Leu-Arg-Glu-Ala
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?
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Arg-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Arg-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Arg-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
53.7% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Asn-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Asn-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Asn-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Asn-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
30.3% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Asp-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Asp-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Asp-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
32.2% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Ala-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Ala-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Ala-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
12.1% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Ile-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Ile-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Ile-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
36.3% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Leu-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Leu-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Leu-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
2.5% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Phe + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Phe + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Phe + Phe(NO2)-Val-Arg-Lys-Ala
48.1% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Glu-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Glu-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Glu-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
50% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Tyr-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Tyr-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Tyr-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
45% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Val-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Val-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Val-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Val-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
3% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-Pro-Gln-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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-
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?
Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-Pro-Gln-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Thr-Phe-Gln-Ala-Phe(NO2)-Pro-Leu-Arg-Glu-Ala-Val + H2O
Thr-Phe-Gln-Ala-Phe(NO2) + Pro-Leu-Arg-Glu-Ala-Val
33% of the activity with Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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-
?
Thr-Phe-Gln-Ala-Phe(NO2)-Pro-Leu-Arg-Glu-Ala-Val + H2O
Thr-Phe-Gln-Ala-Phe(NO2) + Pro-Leu-Arg-Glu-Ala-Val
42% of the activity with Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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-
?
additional information
?
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the enzyme prefers hydrophobic residues with bulky side chains (Met, Tyr, Phe) in P3, although Arg and Gln can also be accepted. Small hydrophobic residues are required in P2 and P2', and large hydrophobic residues (Tyr, Met, Phe, Phe(NO2)) are preferred in both P1 and P1'
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?
additional information
?
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hydrophobic or aromatic residues are preferable in P1 position, a broad variety of residues are acceptable in P3, the residues occupying P2 plays the decisive role in substrate cleavage, Glu is the preferred amino acid at this position. No cleavage: Ala-Thr-His-Gln-Val-Ser-Phe(NO2)-Val-Arg-Lys-Ala, Ala-Thr-His-Gln-Val-Arg-Phe(NO2)-Val-Arg-Lys-Ala, Ala-Thr-His-Gln-Val-Glu-Phe(NO2)-Val-Arg-Lys-Ala, Ala-Thr-His-Gln-Gly-Tyr-Phe(NO2)-Val-Arg-Lys-Ala, Ala-Thr-His-Gln-Phe-Tyr-Phe(NO2)-Val-Arg-Lys-Ala , Ala-Thr-His-Pro-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
cleavage of ALV PR76Gag and HIV-1 polyprotein is stimulated by high salt concentrations
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Ala-Thr-His-Gln-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Gln-His-Thr-Ala
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Ala-Thr-His-Gln-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Arg-Lys-Ala
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Arg-Arg-Arg-Met-Val-((3S,4S)-4-amino-3-hydroxy-6-methylthiohexanoic acid)-Val-Met-Pro
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Arg-Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-mercaptopentanoic acid)-Val-Met-Pro
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Arg-Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Met-Pro
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butyloxycarbonyl-Tyr-Val-statine-Ala-statine methyl ester
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-
Cys-Thr-Asn-Leu-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ile-Ser-Pro-Ile
-
-
Cys-Thr-Asn-Leu-PhePSI[CH2NH]-Pro-Ile-Ser-Pro-Ile
-
-
Gly-Pro-Val-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Ser-Thr-Ala
-
-
Pro-Ala-Val-statine-Ala-Met-Thr-Met
-
IC50 above 1.5 mM, Ki-value above 0.16 mM
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-mercaptopentanoic acid)-Val-Arg-Pro
-
-
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Pro
-
IC50 is above 0.06 mM
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr
-
IC50: 0.04 mM
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Arg-Pro
-
-
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-6-methylthiohexanoic acid)-Val-Arg-Pro
-
-
Pro-Cys-Val-((3S,4S)-4-amino-7-guanidino-3-hydroxyheptanoic acid)-Val-Arg-Pro
-
-
Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Arg-Pro
-
-
Pro-Phe-Gln-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Gln-Phe-Pro
-
-
Pro-Pro-Ala-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Ala-Met-Thr-Met
-
IC50: 0.037 mM
Pro-Pro-Ala-Val-D-Ser-Leu-Ala-Met-Thr-Met
-
IC50: above 1.5 mM, Ki-value: above 0.05 mM
Pro-Pro-Ala-Val-Ser-D-Leu-Ala-Met-Thr-Met
-
IC50: above 1.5 mM, Ki-value: above 0.06 mM
Pro-Pro-Ala-Val-statine-Ala-Met-Thr-Met
-
IC50: above 1.5 mM, Ki-value: above 0.1 mM
Pro-Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
-
IC50: 0.009 mM
Pro-Pro-Gln-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Gln-Pro-Pro
-
-
Pro-Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Pro-Pro
-
-
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-(4-nitrophenyl)pentanoic acid)-Ala-Met-Thr-Met
-
IC50: 0.0125 mM
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Gly-Leu-Tyr-Pro
-
-
Pro-Pro-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
-
IC50: 0.003 mM
Pro-Thr-Phe-Gln-Ala-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Leu-Arg-Glu-Ala-Pro
-
-
Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Arg-Pro
-
-
Thr-Phe-Cys-Ala-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Leu-Arg-Glu-Ala
-
-
Thr-Phe-Gln-Ala-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Gln-Phe-Thr
-
-
Thr-Phe-Gln-Ala-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Leu-Arg-Glu-Ala
-
-
Thr-Phe-Gln-Ala-Phe[CH2-NH]Pro-Leu-Arg-Glu-Ala
-
IC50: 1.1 mM
Thr-Phe-[(S-methylcysteine)-Ala-(3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid]-Leu-Arg-Glu-Ala
-
-
Thr-Thr-Phe-Gln-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Gln-Phe-Thr
-
-
Pro-Cys-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Val-Arg-Pro
-
-
Pro-Cys-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Val-Arg-Pro
-
IC50: 0.06 mM
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
-
IC50: 0.0125 mM
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
-
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Sarcoma, Avian
Isolation, biochemical characterization and crystallization of the p15gag proteinase of myeloblastosis associated virus expressed in E. coli.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.017
Ala-Thr-His-Asn-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.052
Ala-Thr-His-Gln-Val-Leu-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.014
Ala-Thr-His-Val-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.008
Ala-Thr-Pro-Cys-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.009
Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.004
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.024
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.024
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.007
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.025
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.025
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.007
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.009
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.009
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.007
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.042
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.042
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.025
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.12
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.12
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.013
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.031
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.031
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.007
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.075
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.082
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.003
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.0033
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.006
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.006
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.0062
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.0016
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.002
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.026
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.026
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2
Ala-Thr-His-Asn-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
4
Ala-Thr-His-Gln-Val-Leu-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
6
Ala-Thr-His-Val-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
3
Ala-Thr-Pro-Cys-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
5
Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
3
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
3
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
3.1
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
4
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
4.3
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
11
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
1
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
1
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
1.4
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
11
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.5
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.5
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
2.5
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
2.6
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
2
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
2
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
3.9
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
4
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.2
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.2
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
1.5
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
3
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
3
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
3.2
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
7
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
7.1
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
4.9
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
5
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
5
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
9
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
4.7
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
5
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
5
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
5
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
6.8
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
7
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
11
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
11
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00013
Ala-Thr-His-Gln-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Gln-His-Thr-Ala
-
pH 6.0, 37°C
0.00016
Ala-Thr-His-Gln-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Arg-Lys-Ala
-
pH 6.0, 37°C
0.000172
Arg-Arg-Arg-Met-Val-((3S,4S)-4-amino-3-hydroxy-6-methylthiohexanoic acid)-Val-Met-Pro
-
pH 6.0, 37°C
0.0059
Arg-Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-mercaptopentanoic acid)-Val-Met-Pro
-
pH 6.0, 37°C
0.0026
Arg-Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Met-Pro
-
pH 6.0, 37°C
0.00028
butyloxycarbonyl-Tyr-Val-statine-Ala-statine methyl ester
-
pH 6.0, 37°C
0.00518
Cys-Thr-Asn-Leu-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ile-Ser-Pro-Ile
-
-
0.00436
Cys-Thr-Asn-Leu-PhePSI[CH2NH]-Pro-Ile-Ser-Pro-Ile
-
pH 6.0, 37°C
0.00024
Gly-Pro-Val-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Ser-Thr-Ala
-
pH 6.0, 37°C
0.016
His-Pro-His-Leu-Ser-PhePSI[CH2NH]-Met-Ala-Tyr
-
pH 6.0, 37°C
0.09
His-Ser-Leu-Arg-PhePSI[CH2NH]Phe-Arg-Leu-Pro
-
pH 6.0, 37°C
0.02
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Pro
-
pH 6.0, 37°C
0.00003
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr
-
pH 6, 37°C
0.0011
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-6-methylthiohexanoic acid)-Val-Arg-Pro
-
pH 6.0, 37°C
0.00004
Pro-Cys-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Val-Arg-Pro
-
pH 6.0, 37°C
0.00039
Pro-Cys-Val--((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Arg-Pro
-
pH 6.0, 37°C
0.00016
Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Arg-Pro
-
pH 6.0, 37°C
0.00025
Pro-Pro-Ala-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Ala-Met-Thr-Met
-
pH 6, 37°C
0.0052
Pro-Pro-Gln-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Gln-Pro-Pro
-
pH 6.0, 37°C
0.00312
Pro-Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Pro-Pro
-
pH 6.0, 37°C
0.0002
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-(4-nitrophenyl)pentanoic acid)-Ala-Met-Thr-Met
-
pH 6.0, 37°C
0.000005 - 0.00001
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
0.019
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Gly-Leu-Tyr-Pro
-
pH 6.0, 37°C
0.00095
Pro-Pro-Tyr-Val-statine-Gly-Leu-Tyr-Pro
-
pH 6.0, 37°C
0.00001
Pro-Pro-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
-
pH 6.0, 37°C
0.000065
Pro-Thr-Phe-Gln-Ala-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Leu-Arg-Glu-Ala-Pro
-
pH 6, 37°C
0.00043
Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Arg-Pro
-
pH 6.0, 37°C
0.00157
Thr-Phe-(S-methylcysteine)-Ala-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Leu-Arg-Glu-Ala
-
pH 6, 37°C
0.00032
Thr-Phe-Cys-Ala-[(3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid]-Leu-Arg-Glu-Ala
-
pH 6, 37°C
0.00013
Thr-Phe-Gln-Ala-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Gln-Phe-Thr
-
pH 6.0, 37°C
0.00087
Thr-Phe-Gln-Ala-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Leu-Arg-Glu-Ala
-
pH 6, 37°C
0.0158
Thr-Phe-Gln-Ala-PhePSI[CH2-NH]Pro-Leu-Arg-Glu-Ala
-
pH 6.0, 37°C
0.000026
Thr-Thr-Phe-Gln-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Gln-Phe-Thr
-
pH 6.0, 37°C
additional information
additional information
-
Ki-value for Pro-Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met is below 0.01 mM. The Ki-value for Pro-Phe-Gln-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Gln-Phe-Pro, Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-mercaptopentanoic acid)-Val-Arg-Pro and Pro-Cys-Val-((3S,4S)-4-amino-7-guanidino-3-hydroxyheptanoic acid)-Val-Arg-Pro are above 0.1 mM: The Ki-value for Met-Ser-Leu-Asn-statine-Val-Ala-Lys-Val is above 0.08 mM
-
0.000005
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
pH 6.0, 40°C
0.00001
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
-
pH 6.0, 37°C
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
1.5
Pro-Ala-Val-statine-Ala-Met-Thr-Met
Avian myeloblastosis-associated virus
-
IC50 above 1.5 mM, Ki-value above 0.16 mM
0.06
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Pro
Avian myeloblastosis-associated virus
-
IC50 is above 0.06 mM
0.04
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr
Avian myeloblastosis-associated virus
-
IC50: 0.04 mM
0.06
Pro-Cys-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Val-Arg-Pro
Avian myeloblastosis-associated virus
-
IC50: 0.06 mM
0.037
Pro-Pro-Ala-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Ala-Met-Thr-Met
Avian myeloblastosis-associated virus
-
IC50: 0.037 mM
1.5
Pro-Pro-Ala-Val-D-Ser-Leu-Ala-Met-Thr-Met
Avian myeloblastosis-associated virus
-
IC50: above 1.5 mM, Ki-value: above 0.05 mM
1.5
Pro-Pro-Ala-Val-Ser-D-Leu-Ala-Met-Thr-Met
Avian myeloblastosis-associated virus
-
IC50: above 1.5 mM, Ki-value: above 0.06 mM
1.5
Pro-Pro-Ala-Val-statine-Ala-Met-Thr-Met
Avian myeloblastosis-associated virus
-
IC50: above 1.5 mM, Ki-value: above 0.1 mM
0.009
Pro-Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
Avian myeloblastosis-associated virus
-
IC50: 0.009 mM
0.0125
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-(4-nitrophenyl)pentanoic acid)-Ala-Met-Thr-Met
Avian myeloblastosis-associated virus
-
IC50: 0.0125 mM
0.0125
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
Avian myeloblastosis-associated virus
-
IC50: 0.0125 mM
0.003
Pro-Pro-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
Avian myeloblastosis-associated virus
-
IC50: 0.003 mM
1.1
Thr-Phe-Gln-Ala-Phe[CH2-NH]Pro-Leu-Arg-Glu-Ala
Avian myeloblastosis-associated virus
-
IC50: 1.1 mM
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5.5
6.5
6.5
reaction with Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). GAG_AVIMA
124
0
13596
Swiss-Prot
-
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
14000
14000
x * 14000, in contrast to gel filtration, ultracentrifugation data show that the enzyme is present in dimeric and multimeric forms, SDS-PAGE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
?
x * 14000, in contrast to gel filtration, ultracentrifugation data show that the enzyme is present in dimeric and multimeric forms, SDS-PAGE
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
A100L/V104T/R105P/G106V/S107N
A100L/V104T/R105P/G106V/S107N
-
5 key residues predicted to form part of the enzyme subsites S1, S2, and S3 are changed to the residues occupying a similar or identical position in the HIV-1 enzyme. At pH 6.0, the mutated enzyme exhibits more than one order of magnitude higher activity than the wild-type, for all peptide substrates tested. Catalytic efficiency (ratio of turnover number: Km-value) is much closer to that of HIV-1 protease than to the wild-type enzyme, regardless of the amino acid residue occuring in P1, P2 or p3 of the substrate series
A100L/V104T/R105P/G106V/S107N
-
proteolytic activity of the mutant enzyme is higher than that of the wild-type enzyme. For Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala the parameter turnover-number/Km-value shows a 23fold increase, alteration of the specificity of the mutant enzyme towards that of HIV-1 protease
A100L/V104T/R105P/G106V/S107N
-
the mutant with marked preference for HIC-derived peptide substrates does not cleave the HIV-1 polyprotein
A100L/V104T/R105P/G106V/S107N
-
mutant enzyme shows increased proteolytic activity in vitro, mutant plasmid-transfected turkey fibroblasts display an unimpaired virus production in cell cultures. The mutant progeny virus is infectious and ist pattern of gag processing products appears identical to that of wild-type virus. The predominant morphology of mutant viral particles is altered
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of the truncated precursor (Pr25lac-DELTAgag) in Escherichia coli, structurally correct processing
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Konvalinka, J.; Blaha, I.; Skrabana, R.; Sedlacek, J.; Pichova, I.; Kapralek, F.; Kostka, V.; Strop, P.
Subsite specificity of the proteinase from myeloblastosis associated virus
FEBS Lett.
282
73-76
1991
Avian myeloblastosis-associated virus (P26315)
brenda
Ohlendorf, D.H.; Foundling, S.I.; Wendoloski, J.J.; Sedlacek, J.; Strop, P.; Salemme, F.R.
Structural studies of the retroviral proteinase from avian myeloblastosis associated virus
Proteins
14
382-391
1992
Avian myeloblastosis-associated virus (P26315)
brenda
Pavlickova, L.; Stys, D.; Soucek, M.; Urban, J.; Hruskova, O.; Sedlacek, J.; Strop, P.
15gag proteinase of myeloblastosis-associated virus: specificity studies with substrate-based inhibitors
Arch. Biochem. Biophys.
298
753-756
1992
Avian myeloblastosis-associated virus
brenda
Sedlacek, J.; Fabry, M.; Coward, J.E.; Horejsi, M.; Strop, P.; Luftig, R.B.
Myeloblastosis associated virus (MAV) proteinase site-mutated to be HIV-like has a higher activity and allows production of infectious but morphologically altered virus
Virology
192
667-672
1993
Avian myeloblastosis-associated virus
brenda
Strop, P.; Konvalinka, J.; Stys, D.; Pavlickova, L.; Blaha, I.; Velek, J.; Travnicek, M.; Kostka, V.; Sedlacek, J.
Specificity studies on retroviral proteinase from myeloblastosis-associated virus
Biochemistry
30
3437-3443
1991
Avian myeloblastosis-associated virus (P26315)
brenda
Pichova, I.; Strop, P.; Sedlacek, J.; Kapralek, F.; Benes, V.; Travnicek, M.; Pavlickova, L.; Soucek, M.; Kostka, V.; Foundling, S.
Isolation, biochemical characterization and crystallization of the p15gag proteinase of myeloblastosis associated virus expressed in E. coli
Int. J. Biochem.
24
235-242
1992
Avian myeloblastosis-associated virus (P26315), Avian myeloblastosis-associated virus
brenda
Konvalinka, J.; Horejsi, M.; Andreansky, M.; Novek, P.; Pichova, I.; Blaha, I.; Fabry, M.; Sedlacek, J.; Foundling, S.; Strop, P.
An engineered retroviral proteinase from myeloblastosis associated virus acquires pH dependence and substrate specificity of the HIV-1 proteinase
EMBO J.
11
1141-1144
1992
Avian myeloblastosis-associated virus
brenda
Strop, P.; Horejsi, M.; Konvalinka, J.; Skrabana, R.; Velek, J.; Blaha, I.; Cerna, V.; Pichova, I.; Pavlickova, L.; et al.
Protein-engineered proteinase of myeloblastosis associated virus, an enzyme of high activity and HIV-1 proteinase-like specificity
Adv. Exp. Med. Biol.
306
515-518
1991
Avian myeloblastosis-associated virus
brenda
Strop, P.; Pavlickova, L.; Stys, D.; Soucek, M.; Urban, J.; Hruskova, O.; Kapralek, F.; Jecmen, P.; Sedlacek, J.; Kostka, V.
p15gag proteinase of myeloblastosis associated virus: specificity studies with substrate based inhibitors
Adv. Exp. Med. Biol.
306
519-523
1991
Avian myeloblastosis-associated virus
brenda
Konvalinka, J.; Heuser, A.M.; Hruskova-Heidingsfeldova, O.; Vogt, V.M.; Sedlacek, J.; Strop, P.; Krausslich, H.G.
Proteolytic processing of particle-associated retroviral polyproteins by homologous and heterologous viral proteinases
Eur. J. Biochem.
228
191-198
1995
Avian myeloblastosis-associated virus
brenda
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