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(S)-benzyl 2-(2-(4-hydroxynaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)-2-oxoethylcarbamate + H2O
?
18 kD protein of photosystem II + H2O
?
-
-
-
-
?
2-aminobenzoyl-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-Arg-Pro-Pro-Gly-Phe-Ser-Pro + Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
the fluorescence resonance energy transfer peptide sequence corresponds to bradykinin from human kininogen
-
-
?
2-aminobenzoyl-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-Arg-Pro-Pro-Gly-Phe-Ser-Pro + Phe-Arg-Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
the fluorescence resonance energy transfer peptide sequence corresponds to bradykinin from human kininogen
-
-
?
2-aminobenzoyl-EGPQGLLGA-3-nitrotyrosyl-NH2 + H2O
?
-
-
-
-
?
2-aminobenzoyl-FFQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
?
-
-
-
?
2-aminobenzoyl-FPQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
2-aminobenzoyl-FP + Q-(N-(2,4-dinitrophenyl)ethylenediamine)
-
-
-
?
2-aminobenzoyl-FSQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
?
-
-
-
?
2-aminobenzoyl-Glu-Gly-L-Phe-Gly-L-Pro-L-Phe-Gly-L-4-nitrophenylalanine-L-Ala + H2O
2-aminobenzoyl-Glu-Gly-L-Phe-Gly-L-Pro + L-Phe-Gly-L-4-nitrophenylalanine-L-Ala
-
-
-
-
?
2-aminobenzoyl-Glu-Gly-Phe-Ser-Pro-Phe(NO2)-Arg-Ala + H2O
2-aminobenzoyl-Glu-Gly-Phe-Ser-Pro + Phe(NO2)-Arg-Ala
-
-
?
2-aminobenzoyl-Glu-Phe-Ser-Pro-Phe(NO2)-Arg-Ala + H2O
2-aminobenzoyl-Glu-Phe-Ser-Pro + Phe(NO2)-Arg-Ala
-
-
?
2-aminobenzoyl-Gly-Glu-Ser-Pro-Phe(NO2)-Arg-Ala + H2O
2-aminobenzoyl-Gly-Glu-Ser-Pro + Phe(NO2)-Arg-Ala
-
-
?
2-aminobenzoyl-Gly-L-Phe-Gly-L-Pro-L-Phe-Gly-L-4-nitrophenylalanine-L-Ala + H2O
2-aminobenzoyl-Gly-L-Phe-Gly-L-Pro + L-Phe-Gly-L-4-nitrophenylalanine-L-Ala
-
-
-
-
?
2-aminobenzoyl-Gly-L-Phe-L-Arg-L-Pro-L-4-nitrophenylalanine-L-Arg-L-Ala + H2O
2-aminobenzoyl-Gly-L-Phe-L-Arg-L-Pro + L-4-nitrophenylalanine-L-Arg-L-Ala
-
-
-
-
?
2-aminobenzoyl-Gly-Phe-Arg-Pro-Phe(NO2)-Arg-Ala + H2O
2-aminobenzoyl-Gly-Phe-Arg-Pro + Phe(NO2)-Arg-Ala
-
-
?
2-aminobenzoyl-Gly-Phe-Glu-Pro-Phe(NO2)-Arg-Ala + H2O
2-aminobenzoyl-Gly-Phe-Glu-Pro + Phe(NO2)-Arg-Ala
-
-
?
2-aminobenzoyl-Gly-Phe-Gly-Pro-Phe-Gly-Phe(NO2)-Ala + H2O
?
-
-
-
-
?
2-aminobenzoyl-Gly-Phe-Gly-Pro-Phe-Gly-Phe(NO2)-Ala-NH2 + H2O
2-aminobenzoyl-Gly-Phe-Gly-Pro + Phe-Gly-Phe(NO2)-Ala-NH2
2-aminobenzoyl-Gly-Phe-Ser-Pro-Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-Gly-Phe-Ser-Pro + Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
a fluorescence resonance energy transfer peptide
-
-
?
2-aminobenzoyl-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-Gly-Phe-Ser-Pro + Phe-Arg-Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
the fluorescence resonance energy transfer peptide sequence corresponds to bradykinin from human kininogen
-
-
?
2-aminobenzoyl-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Ile-Gly-GLu-Ile-Lys-Glu-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-Gly-Phe-Ser-Pro + Phe-Arg-Ser-Ser-Arg-Ile-Gly-GLu-Ile-Lys-Glu-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
the fluorescence resonance energy transfer peptide sequence corresponds to bradykinin from human kininogen
-
-
?
2-aminobenzoyl-Gly-Pro-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-Gly-Pro + Gln-N-(2,4-dinitrophenyl)ethylenediamine
2-aminobenzoyl-Gly-Pro-Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-Gly-Pro + Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
a fluorescence resonance energy transfer peptide
-
-
?
2-aminobenzoyl-Gly-Pro-Phe-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-Gly-Pro + Phe-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
a fluorescence resonance energy transfer peptide
-
-
?
2-aminobenzoyl-Gly-Ser-Pro-Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-Gly-Ser-Pro + Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
a fluorescence resonance energy transfer peptide
-
-
?
2-aminobenzoyl-L-Ser-L-Pro-L-4-nitrophenylalanine-L-Ala + H2O
2-aminobenzoyl-L-Ser-L-Pro + 4-nitrophenylalanine-L-Ala
-
-
-
-
?
2-aminobenzoyl-RPPGFQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
?
-
-
-
?
2-aminobenzoyl-RPPGFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
2-aminobenzoyl-RPP + GFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)
-
-
-
?
2-aminobenzoyl-SPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
?
-
-
-
?
4-((4-(dimethylamino)phenyl)azo)benzoyl-GPQGLLGA-L-glutamyl-gamma-(2-(1-sulfonyl-5-naphthyl)-aminoethylamide)-NH2 + H2O
?
-
-
-
-
?
Abz-Ala-Ala-Pro-4-nitrophenylalanine + H2O
Abz-Ala-Ala-Pro + 4-nitrophenylalanine
Abz-Ala-Pro-Ala-4-nitrophenylalanine + H2O
Abz-Ala-Pro + L-Ala-4-nitrophenylalanine
Abz-Ala-Pro-Gly-4-nitrophenylalanine + H2O
Abz-Ala-Pro + Gly-4-nitrophenylalanine
Abz-Gly-Gly-Pro-4-nitrophenylalanine + H2O
Abz-Gly-Gly-Pro + 4-nitrophenylalanine
Abz-Gly-L-Phe-L-Arg-L-Pro-L-Phe(NO2)-L-Arg-L-Ala + H2O
Abz-Gly-L-Phe-L-Arg-L-Pro + L-Phe(NO2)-L-Arg-L-Ala
-
-
-
-
?
Abz-Gly-L-Phe-L-Ser-L-Pro-L-Phe-L-Arg-L-Ser-L-Ser-L-Arg-L-Ile-Gly-L-Glu-L-Ile-L-Lys-L-Glu-L-Glu-L-Gln-N-(2,4-dinitrophenyl)-ethylenediamine + H2O
Abz-Gly-L-Phe-L-Ser-L-Pro + L-Phe-L-Arg-L-Ser-L-Ser-L-Arg-L-Ile-Gly-L-Glu-L-Ile-L-Lys-L-Glu-L-Glu-L-Gln-N-(2,4-dinitrophenyl)-ethylenediamine
-
-
-
-
?
Abz-Gly-Pro-4-nitrophenylalanine + H2O
Abz-Gly-Pro + 4-nitrophenylalanine
Abz-Lys-Pro-4-nitrophenylalanine + H2O
Abz-Lys-Pro + 4-nitrophenylalanine
AbzGFGPFGF(p-NO2)A-NH2 + H2O
AbzGFGP + FGF(p-NO2)A-NH2
-
assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min
-
-
?
Ac-CDPGYIGSR-NH2 + H2O
?
-
substrate specificity studies on membrane PE as compared with POP. ZPP-sensitive cleavage of both occurred
-
-
?
Ala-Ala-Pro-4-nitroanilide + H2O
Ala-Ala-Pro + 4-nitroaniline
-
-
-
-
?
Ala-Gly-Pro-beta-naphthylamide + H2O
Ala-Gly-Pro + 2-naphthylamine
Lyophyllum cinerascens
-
-
-
?
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
-
-
-
-
?
Ala-Pro-p-nitroanilide + H2O
Ala-Pro + p-nitroaniline
-
-
-
?
alpa2-antiplasmin + H2O
?
-
not a robust substrate in vitro, the enzyme cleaves after Pro12 in the T9S10G11P12-N13 Q14E15Q16E17 sequence
-
-
?
alpha-melanocyte-stimulating hormone + H2O
?
alpha-melanocyte-stimulating hormone + H2O
acetyl-SYSMEHFRWGKP + L-Val
acetyl-SYSMEHFRWGKPV
-
-
?
alpha-MSH(1-13) + H2O
alpha-MSH(1-12) + Pro
-
increased ratio between substrate and product in pituitaries of prolyl endopeptidase deficient mice compared to wild type mice
-
-
?
alpha-synuclein + H2O
?
-
-
-
-
?
alpha-synulein + H2O
?
-
the enzyme binds to alpha-synuclein and enhances its dimerization
-
-
?
alpha2-gliadin 33-mer + H2O
?
-
the enzyme is able to break down 63% of the 33-mer after 8 h of incubation and it is almost completely degraded after 12 h
-
-
?
angiotensin I + H2O
DRVYIHP + FHL
DRVYIHPFHL
-
-
?
angiotensin II + H2O
DRVYIHP + L-Phe
DRVYIHPF
-
-
?
Arg-Pro-4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
-
-
-
-
?
Arg-Pro-Lys-His-Pro-Ile-Lys-His-Gln + H2O
Arg-Pro-Lys-His-Pro + Ile-Lys-His-Gln
Arg-Pro-p-nitroanilide + H2O
Arg-Pro + p-nitroaniline
-
-
-
?
arginine-vasopressin + H2O
?
Asp-Pro-4-nitroanilide + H2O
Asp-Pro + 4-nitroaniline
-
-
-
-
?
Asp-Pro-p-nitroanilide + H2O
Asp-Pro + p-nitroaniline
-
-
-
?
benzyloxycarbonyl-Ala-Ala-4-nitroanilide + H2O
benzyloxycarbonyl-Ala-Ala + 4-nitroaniline
-
-
-
-
?
benzyloxycarbonyl-Ala-Ala-beta-naphthylamide + H2O
benzyloxycarbonyl-Ala-Ala + beta-naphthylamine
-
-
-
?
benzyloxycarbonyl-Ala-Ala-p-nitroanilide + H2O
benzyloxycarbonyl-Ala-Ala + p-nitroaniline
-
-
-
?
benzyloxycarbonyl-Ala-Ala-p-nitrophenol + H2O
benzyloxycarbonyl-Ala-Ala + p-nitrophenol
-
-
-
?
benzyloxycarbonyl-Ala-Gly-Pro-beta-naphthylamide + H2O
benzyloxycarbonyl-Ala-Gly-Pro + beta-naphthylamine
benzyloxycarbonyl-Ala-Gly-Pro-p-nitrophenol + H2O
benzyloxycarbonyl-Ala-Gly-Pro + p-nitrophenol
-
enzyme from kidney
-
?
benzyloxycarbonyl-Ala-Pro-2-naphthylamide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-Ala-Pro-4-nitroanilide + H2O
benzyloxycarbonyl-Ala-Pro + 4-nitroaniline
-
-
-
-
?
benzyloxycarbonyl-Ala-Pro-beta-naphthylamide + H2O
benzyloxycarbonyl-Ala-Pro + beta-naphthylamine
-
-
-
?
benzyloxycarbonyl-Ala-Pro-p-nitroanilide + H2O
benzyloxycarbonyl-Ala-Pro + p-nitroaniline
benzyloxycarbonyl-Ala-Pro-p-nitrophenol + H2O
benzyloxycarbonyl-Ala-Pro + p-nitrophenol
-
enzyme from kidney
-
?
benzyloxycarbonyl-D-Ala-Gly-Pro-beta-naphthylamide + H2O
benzyloxycarbonyl-D-Ala-Gly-Pro + beta-naphthylamine
benzyloxycarbonyl-D-Ala-Gly-Pro-p-nitrophenol + H2O
benzyloxycarbonyl-D-Ala-Gly-Pro + p-nitrophenol
-
enzyme from kidney
-
?
benzyloxycarbonyl-D-Ala-Pro-beta-naphthylamide + H2O
benzyloxycarbonyl-D-Ala-Pro + beta-naphthylamine
-
-
-
?
benzyloxycarbonyl-Gly-Gly-Pro-p-nitrophenol + H2O
benzyloxycarbonyl-Gly-Gly-Pro + p-nitrophenol
benzyloxycarbonyl-Gly-L-Pro-2-naphthylamide + H2O
benzyloxycarbonyl-Gly-L-Pro + 2-naphthylamine
-
-
-
-
?
benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O
?
benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O
benzyloxycarbonyl-Gly-L-Pro + 4-nitroaniline
benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
?
-
-
-
-
?
benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Gly-L-Pro + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Gly-L-Pro-beta-naphthylamide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-Gly-L-Pro-doxorubicin + H2O
benzyloxycarbonyl-Gly-L-Pro + doxorubicin
-
-
-
-
?
benzyloxycarbonyl-Gly-L-Pro-melphalan + H2O
benzyloxycarbonyl-Gly-L-Pro + melphalan
-
-
-
-
?
benzyloxycarbonyl-Gly-Pro-2-beta-naphthylamide + H2O
?
benzyloxycarbonyl-Gly-Pro-2-naphthylamide + H2O
benzyloxycarbonyl-Gly-Pro + 2-naphthylamine
benzyloxycarbonyl-Gly-Pro-4-methylcoumarin 7-amide + H2O
?
benzyloxycarbonyl-Gly-Pro-4-methylcoumaryl-7-amide + H2O
benzyloxycarbonyl-Gly-Pro + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Gly-Pro-4-nitroanilide + H2O
benzyloxycarbonyl-Gly-Pro + 4-nitroaniline
benzyloxycarbonyl-Gly-Pro-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Gly-Pro + 4-nitrophenol
-
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Ala + H2O
benzyloxycarbonyl-Gly-Pro + Ala
benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O
benzyloxycarbonyl-Gly-Pro + 2-naphthylamine
benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O
benzyloxycarbonyl-Gly-Pro + beta-naphthylamine
benzyloxycarbonyl-Gly-Pro-D-Ala + H2O
benzyloxycarbonyl-Gly-Pro + D-Ala
-
enzyme from kidney
-
?
benzyloxycarbonyl-Gly-Pro-D-Leu + H2O
benzyloxycarbonyl-Gly-Pro + D-Leu
-
enzyme from kidney
-
?
benzyloxycarbonyl-Gly-Pro-Leu + H2O
benzyloxycarbonyl-Gly-Pro + Leu
benzyloxycarbonyl-Gly-Pro-Leu-Ala + H2O
benzyloxycarbonyl-Gly-Pro + Leu-Ala
benzyloxycarbonyl-Gly-Pro-Leu-D-Ala + H2O
benzyloxycarbonyl-Gly-Pro + Leu-D-Ala
benzyloxycarbonyl-Gly-Pro-Leu-Gly + H2O
benzyloxycarbonyl-Gly-Pro + Leu-Gly
benzyloxycarbonyl-Gly-Pro-Leu-Gly-Ala + H2O
benzyloxycarbonyl-Gly-Pro + Leu-Gly-Ala
benzyloxycarbonyl-Gly-Pro-Leu-Gly-D-Ala + H2O
benzyloxycarbonyl-Gly-Pro + Leu-Gly-D-Ala
-
enzyme from kidney
-
?
benzyloxycarbonyl-Gly-Pro-Leu-Gly-Gly + H2O
benzyloxycarbonyl-Gly-Pro + Leu-Gly-Gly
Benzyloxycarbonyl-Gly-Pro-Leu-Gly-Pro + H2O
Benzyloxycarbonyl-Gly-Pro + Leu-Gly-Pro
benzyloxycarbonyl-Gly-Pro-p-nitroanilide + H2O
benzyloxycarbonyl-Gly-Pro + p-nitroaniline
benzyloxycarbonyl-Gly-Pro-p-nitrophenol + H2O
benzyloxycarbonyl-Gly-Pro + p-nitrophenol
benzyloxycarbonyl-Gly-Pro-Phe + H2O
benzyloxycarbonyl-Gly-Pro + Phe
benzyloxycarbonyl-Gly-Pro-SBzl + H2O
benzyloxycarbonyl-Gly-Pro + phenyl-methanethiol
-
-
?
benzyloxycarbonyl-Gly-Pro-thiobenzyl ester + H2O
benzyloxycarbonyl-Gly-Pro + phenylmethanethiol
-
-
-
-
?
benzyloxycarbonyl-glycyl-l-prolyl-4-nitroanilide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-glycyl-proline-p-nitroanilide + H2O
?
benzyloxycarbonyl-L-Ala-L-Ala-L-Pro p-nitroanilide + H2O
?
benzyloxycarbonyl-Pro-p-nitrophenol + H2O
benzyloxycarbonyl-Pro + p-nitrophenol
-
enzyme from kidney
-
?
beta-amyloid + H2O
?
-
-
-
-
?
beta-endorphin + h2O
Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro + Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala + Ile-Ile-Lys-Asn-Ala + Tyr-Lys-Lys-Gly-Glu
-
-
-
?
bradykinin + H2O
Arg-Pro-Pro + Gly-Phe-Ser-Pro + Phe-Arg
-
-
-
?
bradykinin + H2O
RPP + GFSP + L-Phe-L-Arg
RPPGFSPFR
-
-
?
bradykinin potentiating peptide + H2O
?
calcitonin gene-related peptide + H2O
?
-
assay at pH 7.0, 37°C
-
-
?
collagen + H2O
N-acetyl-Pro-Gly-Pro + ?
-
after enzyme activation with LPS
-
-
?
collagen + H2O
Pro-Gly-Pro + ?
-
after enzyme activation with LPS
-
-
?
collagen I + H2O
?
assay at pH 8.0, 37°C
-
-
?
DRVYIHPF + H2O
DRVYIHP + L-Phe
-
-
-
?
EYYDPNYLRT + H2O
EYDP + NYLRT
-
-
-
?
fish muscle collagen + H2O
?
-
the enzyme hydrolysis site is at the carboxyl terminus of prolyl residues
-
-
?
furylacryloyl-Ala-Pro + H2O
?
-
-
-
-
?
FVNEHLCGSHLVQALTLVCGQRGFFYTPLA + H2O
FVNEHLCGSHLVQALTLVCGQRGFFYTP + LA
-
-
-
?
GEPGPPGPA + H2O
GEP + GPPGP + L-Ala
-
-
-
-
?
GFSPFRQED + H2O
GFSP + FRQED
-
-
-
-
?
Gliadin + H2O
?
-
digestion of the gliadin peptide in short peptides with both enzymes S28A and S28B, occur from its N terminus
-
-
?
Gly-L-Pro-4-nitroanilide + H2O
Gly-L-Pro + 4-nitroaniline
Gly-L-Pro-7-amido-4-methylcoumarin + H2O
Gly-L-Pro + 7-amino-4-methylcoumarin
-
-
-
-
?
Gly-Pro-4-methoxy-beta-naphthylamide + H2O
Gly-Pro + 4-methoxy-beta-naphthylamine
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
-
-
-
-
?
Gly-Pro-4-nitrophenyl ester + H2O
Gly-Pro + 4-nitrophenol
Gly-Pro-p-nitroanilide + H2O
Gly-Pro + p-nitroaniline
-
-
-
?
GnRH + H2O
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro + Gly-NH2
-
-
-
?
gonadotropin releasing hormone + H2O
?
GTAGPNQEQE + H2O
GTAGP + NQEQE
-
-
-
-
?
GTSGPNQEQE + H2O
GTSGP + NQEQE
-
-
-
-
?
H-(O2Oc)2-K(Abz)GFGPFGF(p-NO2)A-NH2 + H2O
?
-
assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min
-
-
?
H-Abz-GFGP-OH + H2O
?
-
assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min
-
-
?
H-Abz-GFGPFGF(p-NO2)A-NH2 + H2O
?
-
assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min
-
-
?
H-F(p-NO2)GFGP-OH + H2O
?
-
assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min
-
-
?
H-F(p-NO2)GFGPFGK(Abz)A-(O2Oc)-HMBA-PEGA + H2O
H-F(p-NO2)GFGP + FGK(Abz)A-(O2Oc)-HMBA-PEGA
-
assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min
-
-
?
H-F(p-NO2)GFGPFGK(Abz)A-(O2Oc)-NH2 + H2O
H-F(p-NO2)GFGP + FGK(Abz)A-(O2Oc)-NH2
-
assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min
-
-
?
H-F(p-NO2)GFGPFGK(Abz)A-(O2Oc)2-HMBA-PEGA + H2O
H-F(p-NO2)GFGP + FGK(Abz)A-(O2Oc)2-HMBA-PEGA
-
assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min
-
-
?
H-F(p-NO2)GFGPFGK(Abz)A-(O2Oc)2-NH2 + H2O
H-F(p-NO2)GFGP + FGK(Abz)A-(O2Oc)2-NH2
-
assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min
-
-
?
H-F(p-NO2)GFGPFGK(Abz)A-HMBA-PEGA + H2O
H-F(p-NO2)GFGP + FGK(Abz)A-HMBA-PEGA
-
assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min
-
-
?
H-F(p-NO2)GFGPFGK(Abz)A-NH2 + H2O
H-F(p-NO2)GFGP + FGK(Abz)A-NH2
-
assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min
-
-
?
H-FGF(p-NO2)A-NH2 + H2O
?
-
assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min
-
-
?
H-K(Abz)-GFGPFGF(p-NO2)A-NH2 + H2O
?
-
assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min
-
-
?
H-MDPVDPNIE-OH + H2O
?
-
substrate specificity studies on membrane PE as compared with POP. ZPP-sensitive cleavage of both occurred
-
-
?
H-O2Oc-K(Abz)-GFGPFGF(p-NO2)A-NH2 + H2O
?
-
assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min
-
-
?
H2N-QLQPFPQPQLPY-OH + H2O
?
-
substrate specificity studies on membrane PE as compared with POP. ZPP-sensitive cleavage of both occurred
-
-
?
hemoglobin beta-chain + H2O
?
-
-
-
-
?
ISRPPGFSPFR + H2O
ISRPP + GFSPFR
-
-
-
?
IWGIGCNPWTAEHVDQTLASGNDIC + H2O
cyclic IWGIGCNP + WTAEHVDQTLASGNDIC
-
a peptide with 25 amino acids (25mer, sequence IWGIGCNPWTAEHVDQTLASGNDIC) is utilized by the enzyme as a substrate for the macrocyclization reaction. During the macrocyclase reaction, the enzyme generates an eight-amino acid cyclic peptide from the N-terminal residues (the core, sequence IWGIGCNP), cleaving off the 17-C-terminal amino acid recognition sequence (peptide tail, sequence WTAEHVDQTLASGNDIC)
-
-
?
L-Ala-4-nitroanilide + H2O
L-Ala + 4-nitroaniline
-
-
-
-
?
L-Ala-L-Ala-L-Ala-L-Pro-4-nitroanilide + H2O
L-Ala-L-Ala-L-Ala-L-Pro + 4-nitroaniline
-
-
-
-
?
L-Ala-L-Ala-L-Pro-4-nitroanilide + H2O
L-Ala-L-Ala-L-Pro + 4-nitroaniline
L-Ala-L-Pro-L-Pro-4-nitroanilide + H2O
L-Ala-L-Pro-L-Pro + 4-nitroaniline
-
-
-
-
?
L-His-4-nitroanilide + H2O
L-His + 4-nitroaniline
-
worst substrate
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
-
-
-
?
L-Lys-L-Pro-7-amido-4-methylcoumarin + H2O
L-Lys-L-Pro + 7-amino-4-methylcoumarin
L-Met-4-nitroanilide + H2O
L-Met + 4-nitroaniline
-
-
-
-
?
L-Phe-4-nitroanilide + H2O
L-Phe + 4-nitroaniline
-
best substrate
-
-
?
L-Pro-4-nitroanilide + H2O
L-Pro + 4-nitroaniline
-
-
-
-
?
L-Tyr-4-nitroanilide + H2O
L-Tyr + 4-nitroaniline
-
second best substrate
-
-
?
LQLQPFPQPQLPYPQPQLPYPQPQLPYPQPQPF + H2O
?
-
-
-
-
?
luteinizing-hormone-releasing hormone + H2O
pEHWSYGLRP + Gly
pEHWSYGLRPG
-
-
?
LVVYPWTQRF + H2O
LVVYP + WTQRF
Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
Lys-Arg-Pro-Pro + Gly-Phe-Ser-Pro-Phe-Arg
-
as active as potentiator B
-
?
Me-O-succinyl-Ala-Ala-Val p-nitroanilide + H2O
Me-O-succinyl-Ala-Ala + Val p-nitroanilide
-
-
-
?
membrane-associated glycoprotein neural cell adhesion molecule + H2O
?
-
-
-
-
?
Met-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
Met-Lys-Arg-Pro-Pro + Gly-Phe-Ser-Pro-Phe-Arg
-
as active as potentiator B
-
?
N-benzoyl-L-Phe-L-Val-L-Arg-4-nitroanilide + H2O
?
-
-
-
-
?
N-benzyloxycarbonyl-Ala-Ala-p-nitrophenyl ester + H2O
?
-
-
-
-
?
N-benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
?
-
-
-
-
?
N-benzyloxycarbonyl-Gly-Pro-4-nitrophenyl ester + H2O
N-benzyloxycarbonyl-Gly-Pro + 4-nitrophenol
N-benzyloxycarbonyl-Gly-Pro-Ala + H2O
?
-
-
-
-
?
N-benzyloxycarbonyl-Gly-Pro-p-nitrophenyl ester + H2O
?
-
-
-
-
?
N-carbobenzoxy-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
N-carbobenzoxy-Gly-L-Pro + 7-amino-4-methylcoumarin
-
-
-
-
?
N-carbobenzoxy-Gly-Pro-7-amido-4-methyl-coumarin + H2O
?
-
-
-
-
?
N-carbobenzyloxy-Ala-Pro-2-naphthylamide + H2O
N-carbobenzyloxy-Ala-Pro + 2-naphthylamine
N-carbobenzyloxy-glycyl-proline-4-methyloumarin-7-amide + H2O
N-carbobenzyloxy-glycyl-proline + 7-amino-4-methylcoumarin
-
-
-
-
?
N-Suc-Ala-Ala-Ala-7-amido-4-methylcoumarin + H2O
N-Suc-Ala-Ala-Ala + 7-amino-4-methylcoumarin
assay at pH 7.5, 25°C
-
-
?
N-Suc-Gly-Pro-7-amido-4-methylcoumarin + H2O
N-Suc-Gly-Pro + 7-amino-4-methylcoumarin
assay at pH 7.5, 25°C
-
-
?
N-Suc-Gly-Pro-Leu-Gly-Pro-7-amido-4-methylcoumarin + H2O
N-Suc-Gly-Pro-Leu-Gly-Pro + 7-amino-4-methylcoumarin
assay at pH 7.5, 25°C
-
-
?
N-succinyl-Ala-Ala-Ala-4-nitroanilide
N-succinyl-Ala-Ala-Ala + 4-nitroaniline
-
-
-
-
?
N-succinyl-Ala-Pro-4-nitroanilide + H2O
N-succinyl-Ala-Pro + 4-nitroaniline
-
-
-
?
N-succinyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
?
24% of the activity with N-succinyl-Gly-L-Pro-L-Leu-Gly-L-Pro-7-amido-4-methylcoumarin
-
-
?
N-succinyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
N-succinyl-Gly-L-Pro + 7-amino-4-methylcoumarin
-
-
-
-
?
N-succinyl-Gly-L-Pro-L-Leu-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
?
-
-
-
?
N-succinyl-Gly-Pro-7-amido-4-methylcoumarin + H2O
N-succinyl-Gly-Pro + 7-amino-4-methylcoumarin
N-succinyl-Gly-Pro-OH + H2O
?
-
-
-
-
?
N-succinyl-glycyl-proline-4-methylcoumarin-7-amide + H2O
N-succinyl-glycyl-proline + 7-amino-4-methylcoumarin
N-succinyl-glycyl-prolyl-7-amido-4-methylcoumarin + H2O
N-succinyl-glycyl-prolyl + 7-amino-4-methylcoumarin
N-succinyl-L-Ala-L-Ala-L-Ala-7-amido-4-methylcoumarin + H2O
?
13% of the activity with N-succinyl-Gly-L-Pro-L-Leu-Gly-L-Pro-7-amido-4-methylcoumarin
-
-
?
Nalpha-benzyl-Gly-Pro-Leu-Gly + H2O
?
-
-
-
-
?
Nalpha-benzyloxycarbonyl-Gly-Pro-Leu-Gly + H2O
?
neurotensin + H2O
pELYENKP + RRP + YIL
pELYENKPRRPYIL
-
-
?
neurotensin + H2O
pGlu-Leu-Tyr-Glu-Asn-Lys-Pro + Arg-Arg-Pro + Tyr-Ile-Leu
-
-
-
?
oxytocin + H2O
CYIQNCP + L-Leu-Gly
PEGA(O2Oc)2-K(Abz)GFGPFGF(p-NO2)A-NH2 + H2O
?
-
assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min
-
-
?
PEGA-K(ABz)-GFGPFGF(p-NO2)A-NH2 + H2O
?
-
assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min
-
-
?
PEGA-O2Oc-K(Abz)GFGPFGF(p-NO2)A-NH2 + H2O
?
-
assay at pH 8.0, 37°C, reaction stopped by heating at 95°C for 5 min
-
-
?
peptide QATVGDVNTDRPGLLDLK + H2O
TVGDVNTDRPGLLDLK + GDVNTDRPGLLDLK + QA + QATV
-
i.e. octadecaneuropeptide ODN, the biologically active fragment of diazepam-binding inhibitor, the Ala2 residue is preferred by the enzyme for cleavage, while the Pro-Gly bind is not cleaved, overview
-
-
?
pGlu-Gly-Leu-Pro-Pro-Arg-Pro + H2O
pGlu-Gly-Leu-Pro-Pro + Arg-Pro
-
i.e. potentiator B
-
?
pGlu-Gly-Leu-Pro-Pro-Gly-Pro + H2O
pGlu-Gly-Leu-Pro-Pro + Gly-Pro
-
i.e. potentiator C, as active as potentiator B
-
?
polysialylated membrane-associated glycoprotein neural cell adhesion molecule + H2O
?
-
-
-
-
?
RPKPQQFFGLM + H2O
L-Arg-L-Pro + L-Lys-L-Pro + QQFFGLM
-
-
-
-
?
RPPGFSPFR + H2O
?
-
i.e. bradykinin, 90% of the activity with potentiator B, i.e. pGlu-Gly-Leu-Pro-Pro-Arg-Pro
-
?
RPPGFSPFR-amide + H2O
RPP + GFSPFR-amide
-
i.e. bradykinin, 70% of the activity with potentiator B, i.e. pGlu-Gly-Leu-Pro-Pro-Arg-Pro
-
?
somatostatin-28 (1-12) + H2O
?
-
-
-
-
?
SPRY2 + H2O
?
-
not an in vivo substrate of fibroblast activation protein
-
-
?
substance P + H2O
RPKP + QQFFGLM
RPKPQQFFGLM
-
-
?
Suc-Gly-Pro-7-amido-4-methylcoumarin + H2O
?
-
-
-
-
?
succinyl-Ala-Pro-4-nitrophenyl ester + H2O
succinyl-Ala-Pro + 4-nitrophenol
succinyl-Ala-Pro-p-nitroanilide + H2O
?
-
-
-
?
succinyl-D-Ala-Pro-4-nitroanilide + H2O
benzyloxycarbonyl-D-Ala-Pro + 4-nitroaniline
-
-
-
-
?
succinyl-Gly-L-Pro-4-nitroanilide + H2O
succinyl-Gly-L-Pro + 4-nitroaniline
-
-
-
-
?
succinyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
succinyl-Gly-L-Pro + 7-amino-4-methylcoumarin
succinyl-Gly-L-Pro-L-Leu-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
succinyl-Gly-L-Pro-L-Leu-Gly-L-Pro + 7-amino-4-methylcoumarin
-
-
-
-
?
succinyl-Gly-Pro-4-methylcoumarin 7-amide + H2O
?
succinyl-Gly-Pro-4-methylcoumaryl-7-amide + H2O
succinyl-Gly-Pro + 7-amino-4-methylcoumarin
succinyl-Gly-Pro-7-amido-4-methylcoumarin + H2O
succinyl-Gly-Pro + 7-amino-4-methylcoumarin
-
-
-
-
?
succinyl-Gly-Pro-Leu-Gly-Pro-4-methylcoumaryl-7-amide
?
-
-
-
-
?
succinyl-Gly-Pro-Leu-Gly-Pro-7-amido-4-methylcoumarin + H2O
succinyl-Gly-Pro-Leu-Gly-Pro + 7-amino-4-methylcoumarin
succinyl-Gly-Pro-Leu-Gly-Pro-methylcoumaryl-7-amide + H2O
?
-
-
-
-
?
succinyl-L-Ala-L-Ala-L-Ala-L-Pro-4-nitroanilide + H2O
succinyl-L-Ala-L-Ala-L-Ala-L-Pro + 4-nitroaniline
-
-
-
-
?
succinyl-L-Ala-L-Pro-4-nitroanilide + H2O
succinyl-L-Ala-L-Pro + 4-nitroaniline
-
-
-
-
?
succinyl-L-Arg-L-Pro-4-nitroanilide + H2O
succinyl-L-Arg-L-Pro + 4-nitroaniline
-
-
-
-
?
tasidotin + H2O
tert-butylamine + ?
-
assay at pH 6.8, 37°C
-
-
?
tau protein + H2O
?
-
-
-
-
?
tert-butyloxycarbonyl-Ala-Ala p-nitroanilide + H2O
?
-
-
-
-
?
tert-butyloxycarbonyl-Ala-Ala-Pro-Ala p-nitroanilide + H2O
tert-butyloxycarbonyl-Ala-Ala-Pro + Ala + p-nitoaniline
-
-
-
?
thymosin beta4 + H2O
acetyl-N-L-Ser-L-Asp-L-Lys-L-Pro + ?
-
-
-
-
?
thymosin beta4 + H2O
acetyl-N-Ser-Asp-Lys-Pro + ?
-
prolyl oligopeptidase is a second-step enzyme in the release of acetyl-N-Ser-Asp-Lys-Pro from thymosin beta4 and has autoregulatory effect in the first step
-
-
?
thyrotropin releasing hormone + H2O
?
thyrotropin-releasing hormone + H2O
?
-
-
-
-
?
TRH + H2O
L-pyroglutamyl-L-histidyl-L-proline + NH3
-
-
-
?
Tyr-Gln-Glu-Pro-Val-Leu-Gly-Pro-Val-Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val-p-nitroanilide + H2O
?
urotensin II + H2O
?
-
human substrate, cleavage at the canonical post-proline site
-
-
?
vasopressin + H2O
inactivated vasopressin + dipeptide
-
-
-
?
vassopresin + H2O
CYFQNCP + L-Arg-Gly
CYFQNCPRG
-
-
?
VHLTPVGL + H2O
VHLTP + VGL
-
-
-
?
Z-Ala-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Ala-Pro + 7-amino-4-carbamoylmethylcoumarin
Z-Arg-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Arg-Pro + 7-amino-4-carbamoylmethylcoumarin
Z-Asn-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Asn-Pro + 7-amino-4-carbamoylmethylcoumarin
Z-Asp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Asp-Pro + 7-amino-4-carbamoylmethylcoumarin
Z-Gln-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Gln-Pro + 7-amino-4-carbamoylmethylcoumarin
Z-Glu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Glu-Pro + 7-amino-4-carbamoylmethylcoumarin
Z-Gly-L-Pro-4-nitroanilide + H2O
Z-Gly-L-Pro + 4-nitroaniline
Z-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
Z-Gly-L-Pro + 7-amino-4-methylcoumarin
Z-Gly-Pro-2-naphthylamide + H2O
Z-Gly-Pro + 2-naphthylamine
Z-Gly-Pro-4-nitroanilide + H2O
4-nitroaniline + Z-Gly-Pro
-
pH 7.0, room temperature
-
-
?
Z-Gly-Pro-4-nitroanilide + H2O
Z-Gly-Pro + 4-nitroaniline
-
-
-
-
?
Z-Gly-Pro-4-nitroanilide + H2O
Z-Gly-Pro + p-nitroaniline
Z-Gly-Pro-4-nitroanilide + H2O
Z-glycyl-L-proline + 4-nitroaniline
-
assay at pH 7.0, 30°C
-
-
?
Z-Gly-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Gly-Pro + 7-amino-4-carbamoylmethylcoumarin
Z-Gly-Pro-7-amido-4-methylcoumarin
Z-Gly-Pro + 7-amino-4-methylcoumarin
Z-Gly-Pro-7-amido-4-methylcoumarin + H2O
?
-
-
-
-
?
Z-Gly-Pro-7-amido-4-methylcoumarin + H2O
z-Gly-Pro + 7-amino-4-methylcoumarin
Z-Gly-Pro-p-nitroanilide + H2O
Z-Gly-Pro + p-nitroaniline
-
-
-
-
?
Z-His-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-His-Pro + 7-amino-4-carbamoylmethylcoumarin
Z-Ile-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Ile-Pro + 7-amino-4-carbamoylmethylcoumarin
Z-L-Ala-L-Ala-L-Ala-L-Pro-4-nitroanilide + H2O
Z-L-Ala-L-Ala-L-Ala-L-Pro + 4-nitroaniline
Z-Leu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Leu-Pro + 7-amino-4-carbamoylmethylcoumarin
Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Lys-Pro + 7-amino-4-carbamoylmethylcoumarin
Z-Met-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Met-Pro + 7-amino-4-carbamoylmethylcoumarin
Z-Phe-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Phe-Pro + 7-amino-4-carbamoylmethylcoumarin
Z-Pro-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Pro-Pro + 7-amino-4-carbamoylmethylcoumarin
Z-Ser-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Ser-Pro + 7-amino-4-carbamoylmethylcoumarin
Z-Thr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Thr-Pro + 7-amino-4-carbamoylmethylcoumarin
Z-Trp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Trp-Pro + 7-amino-4-carbamoylmethylcoumarin
Z-Tyr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Tyr-Pro + 7-amino-4-carbamoylmethylcoumarin
Z-Val-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Val-Pro + 7-amino-4-carbamoylmethylcoumarin
additional information
?
-
(S)-benzyl 2-(2-(4-hydroxynaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)-2-oxoethylcarbamate + H2O
?
-
specific substrate, UAMC-00682
-
-
?
(S)-benzyl 2-(2-(4-hydroxynaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)-2-oxoethylcarbamate + H2O
?
-
specific substrate, UAMC-00682
-
-
?
2-aminobenzoyl-Gly-Phe-Gly-Pro-Phe-Gly-Phe(NO2)-Ala-NH2 + H2O
2-aminobenzoyl-Gly-Phe-Gly-Pro + Phe-Gly-Phe(NO2)-Ala-NH2
-
-
?
2-aminobenzoyl-Gly-Phe-Gly-Pro-Phe-Gly-Phe(NO2)-Ala-NH2 + H2O
2-aminobenzoyl-Gly-Phe-Gly-Pro + Phe-Gly-Phe(NO2)-Ala-NH2
-
-
?
2-aminobenzoyl-Gly-Phe-Gly-Pro-Phe-Gly-Phe(NO2)-Ala-NH2 + H2O
2-aminobenzoyl-Gly-Phe-Gly-Pro + Phe-Gly-Phe(NO2)-Ala-NH2
the enzyme binds no more than six residues, P4-P2' even from a longer substrate
-
?
2-aminobenzoyl-Gly-Pro-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-Gly-Pro + Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
a fluorescence resonance energy transfer peptide
-
-
?
2-aminobenzoyl-Gly-Pro-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-Gly-Pro + Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
the fluorescence resonance energy transfer peptide sequence corresponds to bradykinin from human kininogen
-
-
?
Abz-Ala-Ala-Pro-4-nitrophenylalanine + H2O
Abz-Ala-Ala-Pro + 4-nitrophenylalanine
-
about 10% activity compared to Abz-Lys-Pro-4-nitrophenylalanine
-
-
?
Abz-Ala-Ala-Pro-4-nitrophenylalanine + H2O
Abz-Ala-Ala-Pro + 4-nitrophenylalanine
about 50% activity compared to Abz-Lys-Pro-4-nitrophenylalanine
-
-
?
Abz-Ala-Pro-Ala-4-nitrophenylalanine + H2O
Abz-Ala-Pro + L-Ala-4-nitrophenylalanine
-
about 10% activity compared to Abz-Lys-Pro-4-nitrophenylalanine
-
-
?
Abz-Ala-Pro-Ala-4-nitrophenylalanine + H2O
Abz-Ala-Pro + L-Ala-4-nitrophenylalanine
about 27% activity compared to Abz-Lys-Pro-4-nitrophenylalanine
-
-
?
Abz-Ala-Pro-Gly-4-nitrophenylalanine + H2O
Abz-Ala-Pro + Gly-4-nitrophenylalanine
-
about 20% activity compared to Abz-Lys-Pro-4-nitrophenylalanine
-
-
?
Abz-Ala-Pro-Gly-4-nitrophenylalanine + H2O
Abz-Ala-Pro + Gly-4-nitrophenylalanine
about 40% activity compared to Abz-Lys-Pro-4-nitrophenylalanine
-
-
?
Abz-Gly-Gly-Pro-4-nitrophenylalanine + H2O
Abz-Gly-Gly-Pro + 4-nitrophenylalanine
-
about 2% activity compared to Abz-Lys-Pro-4-nitrophenylalanine
-
-
?
Abz-Gly-Gly-Pro-4-nitrophenylalanine + H2O
Abz-Gly-Gly-Pro + 4-nitrophenylalanine
about 20% activity compared to Abz-Lys-Pro-4-nitrophenylalanine
-
-
?
Abz-Gly-Pro-4-nitrophenylalanine + H2O
Abz-Gly-Pro + 4-nitrophenylalanine
-
about 7% activity compared to Abz-Lys-Pro-4-nitrophenylalanine
-
-
?
Abz-Gly-Pro-4-nitrophenylalanine + H2O
Abz-Gly-Pro + 4-nitrophenylalanine
about 20% activity compared to Abz-Lys-Pro-4-nitrophenylalanine
-
-
?
Abz-Lys-Pro-4-nitrophenylalanine + H2O
Abz-Lys-Pro + 4-nitrophenylalanine
-
100% activity
-
-
?
Abz-Lys-Pro-4-nitrophenylalanine + H2O
Abz-Lys-Pro + 4-nitrophenylalanine
100% activity
-
-
?
alpha-gliadin + H2O
?
i.e. PQPQLPYPQPQLPY
-
-
?
alpha-gliadin + H2O
?
i.e. PQPQLPYPQPQLPY
-
-
?
alpha-gliadin + H2O
?
i.e. PQPQLPYPQPQLPY
-
-
?
alpha-melanocyte-stimulating hormone + H2O
?
-
-
-
-
?
alpha-melanocyte-stimulating hormone + H2O
?
-
-
-
-
?
alpha-melanocyte-stimulating hormone + H2O
?
-
-
-
-
?
alpha-melanocyte-stimulating hormone + H2O
?
-
-
-
?
angiotensin I + H2O
?
-
-
-
-
?
angiotensin I + H2O
?
-
-
-
-
?
angiotensin I + H2O
?
-
-
-
?
angiotensin I + H2O
?
-
-
-
-
?
angiotensin I + H2O
?
-
-
-
-
?
angiotensin I + H2O
?
-
-
-
-
?
angiotensin I + H2O
?
-
-
-
-
?
angiotensin I + H2O
?
-
-
-
-
?
angiotensin I + H2O
?
-
-
-
?
angiotensin II + H2O
?
-
-
-
-
?
angiotensin II + H2O
?
-
-
-
-
?
angiotensin II + H2O
?
-
-
-
-
?
angiotensin II + H2O
?
-
-
-
-
?
angiotensin II + H2O
?
-
-
-
?
Arg-Pro-Lys-His-Pro-Ile-Lys-His-Gln + H2O
Arg-Pro-Lys-His-Pro + Ile-Lys-His-Gln
i.e. alphaS1-casein(1-9), cleavage at Pro5-Ile6
-
?
Arg-Pro-Lys-His-Pro-Ile-Lys-His-Gln + H2O
Arg-Pro-Lys-His-Pro + Ile-Lys-His-Gln
i.e. alphaS1-casein(1-9), cleavage at Pro5-Ile6
-
?
arginine-vasopressin + H2O
?
-
-
-
-
?
arginine-vasopressin + H2O
?
-
-
-
-
?
arginine-vasopressin + H2O
?
-
-
-
-
?
arginine-vasopressin + H2O
?
-
-
-
-
?
arginine-vasopressin + H2O
?
-
-
-
?
azocasein + H2O
?
-
-
-
-
?
azocasein + H2O
?
-
poor substrate
-
-
?
barley malt + H2O
?
-
-
-
?
barley malt + H2O
?
-
-
-
?
barley malt + H2O
?
-
-
-
?
benzyloxycarbonyl-Ala-Gly-Pro-beta-naphthylamide + H2O
benzyloxycarbonyl-Ala-Gly-Pro + beta-naphthylamine
-
-
-
?
benzyloxycarbonyl-Ala-Gly-Pro-beta-naphthylamide + H2O
benzyloxycarbonyl-Ala-Gly-Pro + beta-naphthylamine
Lyophyllum cinerascens
-
-
-
?
benzyloxycarbonyl-Ala-Pro-p-nitroanilide + H2O
benzyloxycarbonyl-Ala-Pro + p-nitroaniline
Lyophyllum cinerascens
-
-
-
?
benzyloxycarbonyl-Ala-Pro-p-nitroanilide + H2O
benzyloxycarbonyl-Ala-Pro + p-nitroaniline
-
-
-
?
benzyloxycarbonyl-D-Ala-Gly-Pro-beta-naphthylamide + H2O
benzyloxycarbonyl-D-Ala-Gly-Pro + beta-naphthylamine
-
-
-
?
benzyloxycarbonyl-D-Ala-Gly-Pro-beta-naphthylamide + H2O
benzyloxycarbonyl-D-Ala-Gly-Pro + beta-naphthylamine
Lyophyllum cinerascens
-
-
-
?
benzyloxycarbonyl-Gly-Gly-Pro-p-nitrophenol + H2O
benzyloxycarbonyl-Gly-Gly-Pro + p-nitrophenol
-
-
-
?
benzyloxycarbonyl-Gly-Gly-Pro-p-nitrophenol + H2O
benzyloxycarbonyl-Gly-Gly-Pro + p-nitrophenol
-
enzyme from kidney
-
?
benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O
benzyloxycarbonyl-Gly-L-Pro + 4-nitroaniline
-
-
-
-
?
benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O
benzyloxycarbonyl-Gly-L-Pro + 4-nitroaniline
-
-
-
-
?
benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O
benzyloxycarbonyl-Gly-L-Pro + 4-nitroaniline
-
-
-
-
?
benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O
benzyloxycarbonyl-Gly-L-Pro + 4-nitroaniline
-
-
-
?
benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O
benzyloxycarbonyl-Gly-L-Pro + 4-nitroaniline
-
-
-
?
benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O
benzyloxycarbonyl-Gly-L-Pro + 4-nitroaniline
-
-
-
?
benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Gly-L-Pro + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Gly-L-Pro + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Gly-Pro-2-beta-naphthylamide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-Gly-Pro-2-beta-naphthylamide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-Gly-Pro-2-beta-naphthylamide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-Gly-Pro-2-beta-naphthylamide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-Gly-Pro-2-naphthylamide + H2O
benzyloxycarbonyl-Gly-Pro + 2-naphthylamine
-
-
-
-
?
benzyloxycarbonyl-Gly-Pro-2-naphthylamide + H2O
benzyloxycarbonyl-Gly-Pro + 2-naphthylamine
-
-
-
?
benzyloxycarbonyl-Gly-Pro-4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-Gly-Pro-4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-Gly-Pro-4-methylcoumaryl-7-amide + H2O
benzyloxycarbonyl-Gly-Pro + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Gly-Pro-4-methylcoumaryl-7-amide + H2O
benzyloxycarbonyl-Gly-Pro + 7-amino-4-methylcoumarin
Lyophyllum cinerascens
-
-
-
?
benzyloxycarbonyl-Gly-Pro-4-nitroanilide + H2O
benzyloxycarbonyl-Gly-Pro + 4-nitroaniline
-
-
-
-
?
benzyloxycarbonyl-Gly-Pro-4-nitroanilide + H2O
benzyloxycarbonyl-Gly-Pro + 4-nitroaniline
-
-
-
-
?
benzyloxycarbonyl-Gly-Pro-4-nitroanilide + H2O
benzyloxycarbonyl-Gly-Pro + 4-nitroaniline
-
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Ala + H2O
benzyloxycarbonyl-Gly-Pro + Ala
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Ala + H2O
benzyloxycarbonyl-Gly-Pro + Ala
Lyophyllum cinerascens
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Ala + H2O
benzyloxycarbonyl-Gly-Pro + Ala
-
enzyme from kidney
-
?
benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O
benzyloxycarbonyl-Gly-Pro + 2-naphthylamine
-
-
-
-
?
benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O
benzyloxycarbonyl-Gly-Pro + 2-naphthylamine
-
-
?
benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O
benzyloxycarbonyl-Gly-Pro + beta-naphthylamine
-
-
-
?
benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O
benzyloxycarbonyl-Gly-Pro + beta-naphthylamine
-
-
-
?
benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O
benzyloxycarbonyl-Gly-Pro + beta-naphthylamine
Lyophyllum cinerascens
-
-
-
?
benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O
benzyloxycarbonyl-Gly-Pro + beta-naphthylamine
-
-
?
benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O
benzyloxycarbonyl-Gly-Pro + beta-naphthylamine
-
-
?
benzyloxycarbonyl-Gly-Pro-Leu + H2O
benzyloxycarbonyl-Gly-Pro + Leu
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Leu + H2O
benzyloxycarbonyl-Gly-Pro + Leu
Lyophyllum cinerascens
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Leu + H2O
benzyloxycarbonyl-Gly-Pro + Leu
-
enzyme from kidney
-
?
benzyloxycarbonyl-Gly-Pro-Leu-Ala + H2O
benzyloxycarbonyl-Gly-Pro + Leu-Ala
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Leu-Ala + H2O
benzyloxycarbonyl-Gly-Pro + Leu-Ala
Lyophyllum cinerascens
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Leu-Ala + H2O
benzyloxycarbonyl-Gly-Pro + Leu-Ala
-
enzyme from kidney
-
?
benzyloxycarbonyl-Gly-Pro-Leu-D-Ala + H2O
benzyloxycarbonyl-Gly-Pro + Leu-D-Ala
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Leu-D-Ala + H2O
benzyloxycarbonyl-Gly-Pro + Leu-D-Ala
Lyophyllum cinerascens
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Leu-D-Ala + H2O
benzyloxycarbonyl-Gly-Pro + Leu-D-Ala
-
enzyme from kidney
-
?
benzyloxycarbonyl-Gly-Pro-Leu-Gly + H2O
benzyloxycarbonyl-Gly-Pro + Leu-Gly
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Leu-Gly + H2O
benzyloxycarbonyl-Gly-Pro + Leu-Gly
Lyophyllum cinerascens
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Leu-Gly + H2O
benzyloxycarbonyl-Gly-Pro + Leu-Gly
-
enzyme from kidney
-
?
benzyloxycarbonyl-Gly-Pro-Leu-Gly-Ala + H2O
benzyloxycarbonyl-Gly-Pro + Leu-Gly-Ala
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Leu-Gly-Ala + H2O
benzyloxycarbonyl-Gly-Pro + Leu-Gly-Ala
-
enzyme from kidney
-
?
benzyloxycarbonyl-Gly-Pro-Leu-Gly-Gly + H2O
benzyloxycarbonyl-Gly-Pro + Leu-Gly-Gly
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Leu-Gly-Gly + H2O
benzyloxycarbonyl-Gly-Pro + Leu-Gly-Gly
-
enzyme from kidney
-
?
Benzyloxycarbonyl-Gly-Pro-Leu-Gly-Pro + H2O
Benzyloxycarbonyl-Gly-Pro + Leu-Gly-Pro
Lyophyllum cinerascens
-
-
-
?
Benzyloxycarbonyl-Gly-Pro-Leu-Gly-Pro + H2O
Benzyloxycarbonyl-Gly-Pro + Leu-Gly-Pro
-
enzyme from kidney
-
?
benzyloxycarbonyl-Gly-Pro-p-nitroanilide + H2O
benzyloxycarbonyl-Gly-Pro + p-nitroaniline
-
-
-
?
benzyloxycarbonyl-Gly-Pro-p-nitroanilide + H2O
benzyloxycarbonyl-Gly-Pro + p-nitroaniline
Lyophyllum cinerascens
-
-
-
?
benzyloxycarbonyl-Gly-Pro-p-nitroanilide + H2O
benzyloxycarbonyl-Gly-Pro + p-nitroaniline
-
-
-
?
benzyloxycarbonyl-Gly-Pro-p-nitrophenol + H2O
benzyloxycarbonyl-Gly-Pro + p-nitrophenol
-
-
-
?
benzyloxycarbonyl-Gly-Pro-p-nitrophenol + H2O
benzyloxycarbonyl-Gly-Pro + p-nitrophenol
-
enzyme from kidney
-
?
benzyloxycarbonyl-Gly-Pro-p-nitrophenol + H2O
benzyloxycarbonyl-Gly-Pro + p-nitrophenol
-
-
?
benzyloxycarbonyl-Gly-Pro-Phe + H2O
benzyloxycarbonyl-Gly-Pro + Phe
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Phe + H2O
benzyloxycarbonyl-Gly-Pro + Phe
Lyophyllum cinerascens
-
-
-
?
benzyloxycarbonyl-Gly-Pro-Phe + H2O
benzyloxycarbonyl-Gly-Pro + Phe
-
enzyme from kidney
-
?
benzyloxycarbonyl-glycyl-proline-p-nitroanilide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-glycyl-proline-p-nitroanilide + H2O
?
-
-
-
?
benzyloxycarbonyl-glycyl-proline-p-nitroanilide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-glycyl-proline-p-nitroanilide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-glycyl-proline-p-nitroanilide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-glycyl-proline-p-nitroanilide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-L-Ala-L-Ala-L-Pro p-nitroanilide + H2O
?
-
-
-
-
?
benzyloxycarbonyl-L-Ala-L-Ala-L-Pro p-nitroanilide + H2O
?
-
-
-
-
?
beta-endorphin + H2O
?
-
-
-
-
?
beta-endorphin + H2O
?
-
-
-
-
?
beta-endorphin + H2O
?
-
-
-
-
?
beta-endorphin + H2O
?
-
-
-
?
bradykinin + H2O
?
-
-
-
-
?
bradykinin + H2O
?
-
-
-
-
?
bradykinin + H2O
?
-
-
-
-
?
bradykinin + H2O
?
-
-
-
-
?
bradykinin + H2O
?
-
-
-
?
bradykinin + H2O
?
-
-
-
-
?
bradykinin + H2O
?
-
-
-
-
?
bradykinin + H2O
?
-
-
-
-
?
bradykinin + H2O
?
-
-
-
-
?
bradykinin + H2O
?
-
-
-
?
bradykinin + H2O
?
-
-
-
-
?
bradykinin potentiating peptide + H2O
?
-
-
-
-
?
bradykinin potentiating peptide + H2O
?
-
-
-
-
?
bradykinin potentiating peptide + H2O
?
-
-
-
-
?
bradykinin potentiating peptide + H2O
?
-
-
-
-
?
bradykinin potentiating peptide + H2O
?
-
-
-
-
?
bradykinin potentiating peptide + H2O
?
-
-
-
-
?
bradykinin potentiating peptide + H2O
?
-
-
-
-
?
bradykinin potentiating peptide + H2O
?
-
-
-
?
Collagen + H2O
?
-
-
-
-
?
Collagen + H2O
?
-
-
-
-
?
Collagen + H2O
?
-
the pathogen POP degrades host collagen and fibronectin, facilitating cell invasion, selective inhibitors for trypanosome POP block parasite entry into cells
-
-
?
Collagen + H2O
?
-
host-derived substrate
-
-
?
collagens + H2O
?
-
in host extracellular matrix
-
-
?
collagens + H2O
?
-
mammalian substrate
-
-
?
Fibronectin + H2O
?
-
in host extracellular matrix
-
-
?
Fibronectin + H2O
?
-
the pathogen POP degrades host collagen and fibronectin, facilitating cell invasion, selective inhibitors for trypanosome POP block parasite entry into cells
-
-
?
Fibronectin + H2O
?
-
host-derived substrate
-
-
?
Fibronectin + H2O
?
-
mammalian substrate
-
-
?
gamma-hordein + H2O
?
i.e. SQQQFPQPQQPFPQQP
-
-
?
gamma-hordein + H2O
?
i.e. SQQQFPQPQQPFPQQP
-
-
?
gamma-hordein + H2O
?
i.e. SQQQFPQPQQPFPQQP
-
-
?
gliadins + H2O
?
-
in host gut
-
-
?
gliadins + H2O
?
-
mammalian substrate
-
-
?
gluten + H2O
?
-
-
-
-
?
gluten + H2O
?
-
activity in the human host gastrointestinal tract, overview
-
-
?
gluten + H2O
?
-
degradation of gluten in the human host's intestinal tract, i.e. stomach, duodenum, jejunum, and ileum
-
-
?
gluten + H2O
?
-
determination of activity in a dynamic system that closely mimics the human gastrointestinal tract, overview
-
-
?
gluten peptide + H2O
?
-
-
-
-
?
gluten peptide + H2O
?
-
-
-
-
?
gluten peptide + H2O
?
-
-
-
-
?
gluten peptide + H2O
?
-
-
-
-
?
gluten peptides + H2O
?
-
-
-
-
?
gluten peptides + H2O
?
-
activity in the human host gastrointestinal tract, overview
-
-
?
gluten peptides + H2O
?
-
degradation of gluten peptides in the human host's intestinal tract, i.e. stomach, duodenum, jejunum, and ileum
-
-
?
gluten peptides + H2O
?
-
determination of activity in a dynamic system that closely mimics the human gastrointestinal tract, overview
-
-
?
Gly-L-Pro-4-nitroanilide + H2O
Gly-L-Pro + 4-nitroaniline
-
-
-
?
Gly-L-Pro-4-nitroanilide + H2O
Gly-L-Pro + 4-nitroaniline
-
-
-
-
?
Gly-L-Pro-4-nitroanilide + H2O
Gly-L-Pro + 4-nitroaniline
-
-
-
-
?
Gly-Pro-4-nitrophenyl ester + H2O
Gly-Pro + 4-nitrophenol
-
-
-
?
Gly-Pro-4-nitrophenyl ester + H2O
Gly-Pro + 4-nitrophenol
-
-
-
?
gonadotropin releasing hormone + H2O
?
-
-
-
-
?
gonadotropin releasing hormone + H2O
?
-
-
-
-
?
gonadotropin releasing hormone + H2O
?
-
-
-
-
?
gonadotropin releasing hormone + H2O
?
-
-
-
?
IGF-1 + H2O
?
-
H-Gly-Pro-Glu-OH
-
-
?
IGF-1 + H2O
?
-
H-Gly-Pro-Glu-OH
-
-
?
insulin + H2O
?
-
-
-
?
insulin + H2O
?
-
-
-
-
?
L-Ala-L-Ala-L-Pro-4-nitroanilide + H2O
L-Ala-L-Ala-L-Pro + 4-nitroaniline
-
-
-
-
?
L-Ala-L-Ala-L-Pro-4-nitroanilide + H2O
L-Ala-L-Ala-L-Pro + 4-nitroaniline
-
-
-
-
?
L-Lys-L-Pro-7-amido-4-methylcoumarin + H2O
L-Lys-L-Pro + 7-amino-4-methylcoumarin
-
about 5% activity compared to Z-Gly-L-Pro-7-amido-4-methylcoumarin
-
-
?
L-Lys-L-Pro-7-amido-4-methylcoumarin + H2O
L-Lys-L-Pro + 7-amino-4-methylcoumarin
about 3% activity compared to Z-Gly-L-Pro-7-amido-4-methylcoumarin
-
-
?
Luliberin + H2O
?
-
-
-
-
?
Luliberin + H2O
?
-
-
-
-
?
Luliberin + H2O
?
-
-
-
-
?
Luliberin + H2O
?
-
-
-
-
?
Luliberin + H2O
?
-
-
-
-
?
Luliberin + H2O
?
-
-
-
-
?
Luliberin + H2O
?
-
-
-
-
?
Luliberin + H2O
?
-
-
-
?
LVVYPWTQRF + H2O
LVVYP + WTQRF
-
-
-
?
LVVYPWTQRF + H2O
LVVYP + WTQRF
-
prolyl endopeptidase activity could be the first step of the degradation of LVV-hemorphin-7
-
?
melanotropin + H2O
?
-
-
-
-
?
melanotropin + H2O
?
-
-
-
-
?
melanotropin + H2O
?
-
-
-
-
?
melanotropin + H2O
?
-
-
-
-
?
melanotropin + H2O
?
-
-
-
-
?
melanotropin + H2O
?
-
-
-
-
?
melanotropin + H2O
?
-
-
-
-
?
melanotropin + H2O
?
-
-
-
?
N-benzyloxycarbonyl-Gly-Pro-4-nitrophenyl ester + H2O
N-benzyloxycarbonyl-Gly-Pro + 4-nitrophenol
-
-
-
?
N-benzyloxycarbonyl-Gly-Pro-4-nitrophenyl ester + H2O
N-benzyloxycarbonyl-Gly-Pro + 4-nitrophenol
-
-
-
?
N-carbobenzyloxy-Ala-Pro-2-naphthylamide + H2O
N-carbobenzyloxy-Ala-Pro + 2-naphthylamine
-
-
-
-
?
N-carbobenzyloxy-Ala-Pro-2-naphthylamide + H2O
N-carbobenzyloxy-Ala-Pro + 2-naphthylamine
-
-
-
-
?
N-carbobenzyloxy-Ala-Pro-2-naphthylamide + H2O
N-carbobenzyloxy-Ala-Pro + 2-naphthylamine
-
-
-
-
?
N-succinyl-Gly-Pro-7-amido-4-methylcoumarin + H2O
N-succinyl-Gly-Pro + 7-amino-4-methylcoumarin
-
-
-
-
?
N-succinyl-Gly-Pro-7-amido-4-methylcoumarin + H2O
N-succinyl-Gly-Pro + 7-amino-4-methylcoumarin
-
-
-
-
?
N-succinyl-glycyl-proline-4-methylcoumarin-7-amide + H2O
N-succinyl-glycyl-proline + 7-amino-4-methylcoumarin
-
-
-
-
?
N-succinyl-glycyl-proline-4-methylcoumarin-7-amide + H2O
N-succinyl-glycyl-proline + 7-amino-4-methylcoumarin
-
-
-
-
?
N-succinyl-glycyl-proline-4-methylcoumarin-7-amide + H2O
N-succinyl-glycyl-proline + 7-amino-4-methylcoumarin
-
-
-
-
?
N-succinyl-glycyl-prolyl-7-amido-4-methylcoumarin + H2O
N-succinyl-glycyl-prolyl + 7-amino-4-methylcoumarin
-
-
-
-
?
N-succinyl-glycyl-prolyl-7-amido-4-methylcoumarin + H2O
N-succinyl-glycyl-prolyl + 7-amino-4-methylcoumarin
-
-
-
-
?
Nalpha-benzyloxycarbonyl-Gly-Pro-Leu-Gly + H2O
?
-
-
-
-
?
Nalpha-benzyloxycarbonyl-Gly-Pro-Leu-Gly + H2O
?
-
-
-
-
?
neurotensin + H2O
?
-
-
-
-
?
neurotensin + H2O
?
-
-
-
-
?
neurotensin + H2O
?
-
-
-
?
neurotensin + H2O
?
-
-
-
-
?
neurotensin + H2O
?
-
-
-
-
?
neurotensin + H2O
?
-
-
-
-
?
neurotensin + H2O
?
-
-
-
-
?
neurotensin + H2O
?
-
-
-
-
?
neurotensin + H2O
?
-
-
-
-
?
neurotensin + H2O
?
-
-
-
?
oxytocin + H2O
?
-
-
-
-
?
oxytocin + H2O
?
-
-
-
-
?
oxytocin + H2O
?
-
-
-
-
?
oxytocin + H2O
?
-
-
-
-
?
oxytocin + H2O
?
-
-
-
-
?
oxytocin + H2O
?
-
-
-
-
?
oxytocin + H2O
?
-
-
-
-
?
oxytocin + H2O
CYIQNCP + L-Leu-Gly
-
-
-
?
oxytocin + H2O
CYIQNCP + L-Leu-Gly
CYIQNCPLG
-
-
?
oxytoxin + H2O
?
-
-
-
-
?
oxytoxin + H2O
?
-
-
-
-
?
oxytoxin + H2O
?
-
-
-
-
?
Peptides + H2O
?
-
involved in process of fertilization, between chorion elevation and cell cleavage
-
-
?
Peptides + H2O
?
-
metabolism of peptides containing altered aspartyl residues
-
-
?
Substance P + H2O
?
-
-
-
-
?
Substance P + H2O
?
-
-
-
-
?
Substance P + H2O
?
-
-
-
-
?
Substance P + H2O
?
-
-
-
-
?
Substance P + H2O
?
-
-
-
-
?
Substance P + H2O
?
-
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
-
-
?
Substance P + H2O
?
-
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
-
-
?
Substance P + H2O
?
-
-
-
-
?
Substance P + H2O
?
-
-
-
-
?
Substance P + H2O
?
-
-
-
-
?
Substance P + H2O
?
-
-
-
?
succinyl-Ala-Pro-4-nitrophenyl ester + H2O
succinyl-Ala-Pro + 4-nitrophenol
-
-
-
?
succinyl-Ala-Pro-4-nitrophenyl ester + H2O
succinyl-Ala-Pro + 4-nitrophenol
-
-
-
?
succinyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
succinyl-Gly-L-Pro + 7-amino-4-methylcoumarin
-
-
-
-
?
succinyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
succinyl-Gly-L-Pro + 7-amino-4-methylcoumarin
-
-
-
-
?
succinyl-Gly-Pro-4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
succinyl-Gly-Pro-4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
succinyl-Gly-Pro-4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
succinyl-Gly-Pro-4-methylcoumaryl-7-amide + H2O
succinyl-Gly-Pro + 7-amino-4-methylcoumarin
-
-
-
?
succinyl-Gly-Pro-4-methylcoumaryl-7-amide + H2O
succinyl-Gly-Pro + 7-amino-4-methylcoumarin
-
-
-
?
succinyl-Gly-Pro-4-methylcoumaryl-7-amide + H2O
succinyl-Gly-Pro + 7-amino-4-methylcoumarin
-
-
-
?
succinyl-Gly-Pro-4-methylcoumaryl-7-amide + H2O
succinyl-Gly-Pro + 7-amino-4-methylcoumarin
-
-
-
?
succinyl-Gly-Pro-Leu-Gly-Pro-7-amido-4-methylcoumarin + H2O
succinyl-Gly-Pro-Leu-Gly-Pro + 7-amino-4-methylcoumarin
-
about 58% activity compared to Z-Gly-L-Pro-7-amido-4-methylcoumarin
-
-
?
succinyl-Gly-Pro-Leu-Gly-Pro-7-amido-4-methylcoumarin + H2O
succinyl-Gly-Pro-Leu-Gly-Pro + 7-amino-4-methylcoumarin
about 65% activity compared to Z-Gly-L-Pro-7-amido-4-methylcoumarin
-
-
?
thyroliberin + H2O
?
-
-
-
-
?
thyroliberin + H2O
?
-
-
-
-
?
thyroliberin + H2O
?
-
-
-
?
thyroliberin + H2O
?
-
-
-
-
?
thyroliberin + H2O
?
-
-
-
-
?
thyroliberin + H2O
?
-
-
-
-
?
thyroliberin + H2O
?
-
-
-
-
?
thyroliberin + H2O
?
-
-
-
-
?
thyroliberin + H2O
?
-
-
-
?
thyrotropin releasing hormone + H2O
?
-
-
-
-
?
thyrotropin releasing hormone + H2O
?
-
-
-
-
?
thyrotropin releasing hormone + H2O
?
-
-
-
-
?
thyrotropin releasing hormone + H2O
?
-
-
-
?
tuftsin + H2O
?
-
-
-
-
?
tuftsin + H2O
?
-
-
-
-
?
tuftsin + H2O
?
-
-
-
-
?
tuftsin + H2O
?
-
-
-
-
?
tuftsin + H2O
?
-
-
-
-
?
tuftsin + H2O
?
-
-
-
-
?
tuftsin + H2O
?
-
-
-
-
?
Tyr-Gln-Glu-Pro-Val-Leu-Gly-Pro-Val-Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val-p-nitroanilide + H2O
?
i.e. N-acetyl-beta-casein-(f203-209)-p-nitroanilide, cleavage at: Pro196-Val197, Pro200-Val201 and Pro206-Ile207
-
?
Tyr-Gln-Glu-Pro-Val-Leu-Gly-Pro-Val-Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val-p-nitroanilide + H2O
?
i.e. N-acetyl-beta-casein-(f203-209)-p-nitroanilide, cleavage at: Pro196-Val197, Pro200-Val201 and Pro206-Ile207
-
?
Vasopressin + H2O
?
-
-
-
-
?
Vasopressin + H2O
?
-
-
-
-
?
Vasopressin + H2O
?
-
-
-
?
Vasopressin + H2O
?
-
-
-
-
?
Vasopressin + H2O
?
-
-
-
-
?
Vasopressin + H2O
?
-
-
-
-
?
Vasopressin + H2O
?
-
-
-
-
?
Vasopressin + H2O
?
-
-
-
-
?
Vasopressin + H2O
?
-
-
-
?
wheat gluten + H2O
?
-
-
-
-
?
wheat gluten + H2O
?
-
-
-
-
?
Z-Ala-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Ala-Pro + 7-amino-4-carbamoylmethylcoumarin
-
about 90% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Ala-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Ala-Pro + 7-amino-4-carbamoylmethylcoumarin
about 60% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Arg-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Arg-Pro + 7-amino-4-carbamoylmethylcoumarin
-
about 87% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Arg-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Arg-Pro + 7-amino-4-carbamoylmethylcoumarin
about 90% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Asn-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Asn-Pro + 7-amino-4-carbamoylmethylcoumarin
-
about 30% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Asn-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Asn-Pro + 7-amino-4-carbamoylmethylcoumarin
about 40% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Asp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Asp-Pro + 7-amino-4-carbamoylmethylcoumarin
-
about 5% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Asp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Asp-Pro + 7-amino-4-carbamoylmethylcoumarin
about 10% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Gln-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Gln-Pro + 7-amino-4-carbamoylmethylcoumarin
-
about 38% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Gln-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Gln-Pro + 7-amino-4-carbamoylmethylcoumarin
about 38% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Glu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Glu-Pro + 7-amino-4-carbamoylmethylcoumarin
-
about 18% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Glu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Glu-Pro + 7-amino-4-carbamoylmethylcoumarin
about 20% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Gly-L-Pro-4-nitroanilide + H2O
Z-Gly-L-Pro + 4-nitroaniline
-
-
-
-
?
Z-Gly-L-Pro-4-nitroanilide + H2O
Z-Gly-L-Pro + 4-nitroaniline
-
-
-
-
?
Z-Gly-L-Pro-4-nitroanilide + H2O
Z-Gly-L-Pro + 4-nitroaniline
-
-
-
-
?
Z-Gly-L-Pro-4-nitroanilide + H2O
Z-Gly-L-Pro + 4-nitroaniline
-
-
-
?
Z-Gly-L-Pro-4-nitroanilide + H2O
Z-Gly-L-Pro + 4-nitroaniline
-
highest activity
-
-
?
Z-Gly-L-Pro-4-nitroanilide + H2O
Z-Gly-L-Pro + 4-nitroaniline
-
highest activity
-
-
?
Z-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
Z-Gly-L-Pro + 7-amino-4-methylcoumarin
-
-
-
-
?
Z-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
Z-Gly-L-Pro + 7-amino-4-methylcoumarin
100% activity
-
-
?
Z-Gly-Pro-2-naphthylamide + H2O
Z-Gly-Pro + 2-naphthylamine
-
-
-
-
?
Z-Gly-Pro-2-naphthylamide + H2O
Z-Gly-Pro + 2-naphthylamine
-
-
-
?
Z-Gly-Pro-4-nitroanilide + H2O
Z-Gly-Pro + p-nitroaniline
assay at pH 8.0, 34°C
-
-
?
Z-Gly-Pro-4-nitroanilide + H2O
Z-Gly-Pro + p-nitroaniline
assay at pH 5.0, 37°C
-
-
?
Z-Gly-Pro-4-nitroanilide + H2O
Z-Gly-Pro + p-nitroaniline
assay at 37°C
-
-
?
Z-Gly-Pro-4-nitroanilide + H2O
Z-Gly-Pro + p-nitroaniline
-
chromogenic assay, assay at pH 7.0, 37°C, reaction stopped by addition of sodium acetate
-
-
?
Z-Gly-Pro-4-nitroanilide + H2O
Z-Gly-Pro + p-nitroaniline
-
assay at 37°C
-
-
?
Z-Gly-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Gly-Pro + 7-amino-4-carbamoylmethylcoumarin
-
about 22% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Gly-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Gly-Pro + 7-amino-4-carbamoylmethylcoumarin
about 70% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Gly-Pro-7-amido-4-methylcoumarin
Z-Gly-Pro + 7-amino-4-methylcoumarin
-
fluorogenic assay, assay at pH 6.8, 37°C, reaction stopped by addition of acetic acid
-
-
?
Z-Gly-Pro-7-amido-4-methylcoumarin
Z-Gly-Pro + 7-amino-4-methylcoumarin
-
assay at pH 8.0, 37°C, reaction stopped with sodium acetate
-
-
?
Z-Gly-Pro-7-amido-4-methylcoumarin
Z-Gly-Pro + 7-amino-4-methylcoumarin
-
assay at pH 7.0, 30°C
-
-
?
Z-Gly-Pro-7-amido-4-methylcoumarin + H2O
z-Gly-Pro + 7-amino-4-methylcoumarin
-
-
-
-
?
Z-Gly-Pro-7-amido-4-methylcoumarin + H2O
z-Gly-Pro + 7-amino-4-methylcoumarin
-
assay at pH 7.0, 30°C
-
-
?
Z-Gly-Pro-7-amido-4-methylcoumarin + H2O
z-Gly-Pro + 7-amino-4-methylcoumarin
-
assay at pH 7.0, 37°C
-
-
?
Z-His-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-His-Pro + 7-amino-4-carbamoylmethylcoumarin
-
about 58% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-His-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-His-Pro + 7-amino-4-carbamoylmethylcoumarin
about 65% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Ile-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Ile-Pro + 7-amino-4-carbamoylmethylcoumarin
-
about 92% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Ile-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Ile-Pro + 7-amino-4-carbamoylmethylcoumarin
about 60% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-L-Ala-L-Ala-L-Ala-L-Pro-4-nitroanilide + H2O
Z-L-Ala-L-Ala-L-Ala-L-Pro + 4-nitroaniline
-
-
-
-
?
Z-L-Ala-L-Ala-L-Ala-L-Pro-4-nitroanilide + H2O
Z-L-Ala-L-Ala-L-Ala-L-Pro + 4-nitroaniline
-
-
-
-
?
Z-Leu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Leu-Pro + 7-amino-4-carbamoylmethylcoumarin
-
about 70% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Leu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Leu-Pro + 7-amino-4-carbamoylmethylcoumarin
about 50% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Lys-Pro + 7-amino-4-carbamoylmethylcoumarin
-
100% activity
-
-
?
Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Lys-Pro + 7-amino-4-carbamoylmethylcoumarin
100% activity
-
-
?
Z-Met-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Met-Pro + 7-amino-4-carbamoylmethylcoumarin
-
about 68% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Met-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Met-Pro + 7-amino-4-carbamoylmethylcoumarin
about 67% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Phe-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Phe-Pro + 7-amino-4-carbamoylmethylcoumarin
-
about 48% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Phe-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Phe-Pro + 7-amino-4-carbamoylmethylcoumarin
about 65% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Pro-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Pro-Pro + 7-amino-4-carbamoylmethylcoumarin
-
about 3% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Pro-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Pro-Pro + 7-amino-4-carbamoylmethylcoumarin
about 3% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Ser-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Ser-Pro + 7-amino-4-carbamoylmethylcoumarin
-
about 30% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Ser-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Ser-Pro + 7-amino-4-carbamoylmethylcoumarin
about 60% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Thr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Thr-Pro + 7-amino-4-carbamoylmethylcoumarin
-
about 75% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Thr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Thr-Pro + 7-amino-4-carbamoylmethylcoumarin
about 50% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Trp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Trp-Pro + 7-amino-4-carbamoylmethylcoumarin
-
about 23% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Trp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Trp-Pro + 7-amino-4-carbamoylmethylcoumarin
about 30% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Tyr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Tyr-Pro + 7-amino-4-carbamoylmethylcoumarin
-
about 60% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Tyr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Tyr-Pro + 7-amino-4-carbamoylmethylcoumarin
about 70% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Val-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Val-Pro + 7-amino-4-carbamoylmethylcoumarin
-
about 20% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Val-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Val-Pro + 7-amino-4-carbamoylmethylcoumarin
about 38% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
leginsulin appears to be a possible candidate for the POP substrate
-
-
?
additional information
?
-
-
no activity with L-Ala-L-Pro-4-nitroanilide and L-Ala-L-Pro-L-Phe-4-nitroanilide
-
-
?
additional information
?
-
-
no activity toward L-Pro-4-nitroanilide, Gly-L-Pro-4-nitroanilide, Z-Pro-nitrophenyl ester, Z-Gly-Gly-nitrophenyl ester, Z-Phe-Arg-7-amido-4-methylcoumarin, Z-Leu-Leu-Glu-7-amido-4-methylcoumarin, Z-Val-Lys-Met-7-amido-4-methylcoumarin, Z-Leu-Leu-Leu-7-amido-4-methylcoumarin, and Z-Tyr-Val-Ala-Asp-4-nitroanilide
-
-
?
additional information
?
-
-
cellular functions, overview, POP may regulate phosphoinositide signaling, overview
-
-
?
additional information
?
-
-
enzyme inhibition leads to inhibition of lithium effects, the loss of enzyme activity evokes a 4fold increase in the inositol-3-phosphate concentration counteracting the Li+ ions, enzyme regulation, overview
-
-
?
additional information
?
-
-
substrate specificity with exclusion of peptides with more than 30 amino acids, overview
-
-
?
additional information
?
-
-
the enzyme hydrolyzes the peptide bond on the carboxyl side of internal proline residues of oligopeptide substrates with up to 30 amino acids, substrate specificity, overview
-
-
?
additional information
?
-
-
requirement for a trans peptide bond immediately preceding the active bond
-
-
?
additional information
?
-
-
cleavage of Pro-X bond
-
-
?
additional information
?
-
-
and more slowly Ala-X bond
-
-
?
additional information
?
-
-
not: (7-D-Pro)oxytocin and high molecular weight proteins even after denaturation
-
-
?
additional information
?
-
-
no hydrolysis of Pro-beta-naphthylamide, benzyloxycarbonyl-Pro-beta-naphthylamide, benzyloxycarbonyl-Ala-p-nitrophenol, Gly-Prp-beta-naphthylamide, Ala-Ala-beta-naphthylamide, benzyloxycarbonyl-Gly-Pro-D-Ala
-
?
additional information
?
-
-
the enzyme plays a role in the metabolism of proline-containing neuropeptides which have been suggested to be involved in learning and memory processes
-
?
additional information
?
-
-
cellular functions, overview
-
-
?
additional information
?
-
-
the enzyme induces cleavage of gluten-derived peptides predigested by pepsin and pancreatic enzymes an exhibiting a detoxifying effect in the host's gut
-
-
?
additional information
?
-
-
the enzyme is a proline-specific endopeptidase with a serine-type mechanism
-
-
?
additional information
?
-
-
substrate specificity with exclusion of peptides with more than 30 amino acids, overview
-
-
?
additional information
?
-
-
substrate specificity, overview, the enzyme hydrolyzes the peptide bond on the carboxyl side of internal proline residues of oligopeptide substrates with up to 30 amino acids, the S2' subsite had the highest specificity of the S1'-S3' subsites, this subsite prefers Pro residues, followed by Leu, Met, Phe, and Ala residues, the S1' subsite has lower specificity than the S2', with the strongest preference for hydrophobic, e.g. Leu, and aromatic, e.g. Phe, residues, and the greatest discrimination against Pro residues
-
-
?
additional information
?
-
-
the enzyme removes most of the gut-digestion-resistant gliadin peptides in the host gut luman of coeliac disease patients, overview, enzyme regulation, overview
-
-
?
additional information
?
-
-
the enzyme cleaves at the C-terminal side of proline residues, the bacterial enzyme is also capable of cleaving Ala-Xaa and Val-Xaa bonds, no activity with large proteins with over 30 amino acids
-
-
?
additional information
?
-
-
succinyl and isoaspartyl containing
-
-
?
additional information
?
-
-
no activity with Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr and pGly-His-Trp-Ser-tyr-Gly-leu-Arg-Pro-Gly-NH2
-
?
additional information
?
-
splice variant PRPL A, no cleavage of peptide substrates containing a P1 basic residue, very slow reaction with activated ester substrate 4-methylumbelliferyl-p-guanidinobenzoate
-
-
?
additional information
?
-
-
cellular functions, overview, POP may regulate phosphoinositide signaling, overview, the enzyme is involved in neuronal degeneration and Alzheimer's disease with enzyme inhibition leading to a reduction of beta-amyloid peptide, overview
-
-
?
additional information
?
-
-
POP activity levels are lowered in different stages of depression, whereas activity is increased in patients with mania and schizophrenia, the antidepressant fluoxetine and the antimanic drug valproic acid both restore POP activity to normal levels
-
-
?
additional information
?
-
-
the enzyme is a serine protease, that digests small peptide-like hormones, neuroactive peptides, and various cellular factors, it is implicated in several biological processes and diseases, e.g. in some psychiatric disorders, most probably through interference in the inositol cycle, it is important in the metabolism of substance P, arginine vasopressin, thyroliberin, and gonadoliberin, enzyme regulation probably involving gluten, prep expression is downregulated in coelic disease patients in complete remission, overview
-
-
?
additional information
?
-
-
the enzyme is involved in the phosphoinositide pathway, in formation and processing of amyloid beta-peptide, protein secretion, and in neuronal differentiation and maturation, overview, the enzyme is involved in several diseases, e.g. celiac disease, Alzheimer's diease, Parkinsons's disease, affective disorders, eating disorders, cancer, inflammation, hypertension, and neurodegenarative disorders, overview, enzyme inhibition positively affects neurodiseases, overview
-
-
?
additional information
?
-
-
the enzyme is involved with the inactivation of regulatory neuropeptides, enzyme activity is correlated to an increase in protein secretion, suggesting that the enzyme may be involved in regulating secretory processes
-
-
?
additional information
?
-
-
the enzyme plays a role in inositol 1,4,5-triphosphate signaling and in the actions of antidepressants, POP inhibitors have antiamnesic and neuroprotective properties, overview
-
-
?
additional information
?
-
-
no activity with gluten in celiac sprue patients, substrate specificity with exclusion of peptides with more than 30 amino acids, overview
-
-
?
additional information
?
-
-
substrate specificity, overview, the enzyme cleaves at the C-terminal side of proline residues and more slowly of alanine residues, no activity with large proteins with over 30 amino acids
-
-
?
additional information
?
-
-
the enzyme cleaves the peptide bond on the C-terminal side of proline in peptides up to approx 30 residues, and hydrolyse several peptide hormones and neuropeptides in vitro
-
-
?
additional information
?
-
-
the enzyme hydrolyzes the peptide bond on the carboxyl side of internal proline residues of oligopeptide substrates with up to 30 amino acids, substrate specificity, overview
-
-
?
additional information
?
-
-
the enzyme shows endopeptidase activity with peptides no longer than 30 amino acids
-
-
?
additional information
?
-
-
cleaves short proline-containing neuropeptides, and is involved in memory and learning
-
-
?
additional information
?
-
-
fibroblast activation protein prefers uncharged residues, including small or bulky hydrophobic amino acids, but not charged amino acids, especially acidic residue at P1, P3 and P4 sites. Fibroblast activation protein cannot cleave interleukins
-
-
?
additional information
?
-
-
prolyl oligopeptidase colocalizes with alpha-synuclein, beta-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinsons and Alzheimers diseases
-
-
?
additional information
?
-
-
does not cleave GASGPAGPA
-
-
?
additional information
?
-
-
no activity with Abz-L-Pro-L-Pro-4-nitrophenylalanine, Abz-L-Pro-L-Pro-L-Ala-4-nitrophenylalanine, Gly-L-Pro-7-amido-4-methylcoumarin, and L-Pro-7-amido-4-methylcoumarin
-
-
?
additional information
?
-
the specificity for post-proline bonds suggests that the enzyme may play a central role in the hydrolysis of casein-derived bitter peptides, such as beta-casein(f193-209)
-
?
additional information
?
-
-
the specificity for post-proline bonds suggests that the enzyme may play a central role in the hydrolysis of casein-derived bitter peptides, such as beta-casein(f193-209)
-
?
additional information
?
-
the specificity for post-proline bonds suggests that the enzyme may play a central role in the hydrolysis of casein-derived bitter peptides, such as beta-casein(f193-209)
-
?
additional information
?
-
-
the specificity for post-proline bonds suggests that the enzyme may play a central role in the hydrolysis of casein-derived bitter peptides, such as beta-casein(f193-209)
-
?
additional information
?
-
-
leginsulin appears to be a possible candidate for the POP substrate
-
-
?
additional information
?
-
Lyophyllum cinerascens
-
no hydrolysis of Pro-beta-naphthylamide, benzyloxycarbonyl-Pro-beta-naphthylamide, Gly-Pro-beta-naphthylamide, benzyloxycarbonyl-Gly-D-Pro-p-nitroanilide, benzyloxycarbonyl-D-Ala-Pro-beta-naphthylamide and benzyloxycarbonyl-Gly-Pro-D-Ala
-
?
additional information
?
-
-
cellular functions, overview, POP may regulate phosphoinositide signaling, overview, the enzyme is involved in Alzheimer's disease with enzyme inhibition leading to a reduction of beta-amyloid peptide, overview
-
-
?
additional information
?
-
-
the enzyme is a serine protease, that digests small peptide-like hormones, neuroactive peptides, and various cellular factors, it is implicated in several biological processes and diseases, e.g. in some psychiatric disorders, most probably through interference in the inositol cycle, it is important in the metabolism of substance P, arginine vasopressin, thyroliberin, and gonadoliberin, enzyme regulation, overview
-
-
?
additional information
?
-
-
the enzyme is involved in the phosphoinositide pathway, in formation and processing of amyloid beta-peptide, protein secretion, and in neuronal differentiation and maturation, overview, the enzyme is involved in several diseases, e.g. celiac disease, Alzheimer's diease, Parkinsons's disease, affective disorders, eating disorders, cancer, inflammation, hypertension, and neurodegenarative disorders, overview, enzyme inhibition can improve the retention time when administered before either the acquisition or the retential trial in scopolamine-induced amnesia, enzyme inhibition positively affects neurodiseases, overview
-
-
?
additional information
?
-
-
substrate specificity with exclusion of peptides with more than 30 amino acids, overview
-
-
?
additional information
?
-
-
substrate specificity, overview, the enzyme cleaves at the C-terminal side of proline residues and more slowly of alanine residues, no activity with large proteins with over 30 amino acids
-
-
?
additional information
?
-
-
the enzyme hydrolyzes the peptide bond on the carboxyl side of internal proline residues of oligopeptide substrates with up to 30 amino acids, substrate specificity, overview
-
-
?
additional information
?
-
-
the enzyme shows endopeptidase activity with peptides no longer than 3 amino acids
-
-
?
additional information
?
-
-
cellular functions, overview
-
-
?
additional information
?
-
-
substrate specificity with exclusion of peptides with more than 30 amino acids, overview
-
-
?
additional information
?
-
-
the enzyme cleaves the peptide bond on the C-terminal side of proline in peptides up to approx 30 residues, substrate entry into the active site cavity, substrate-binding structure and mechanism, overview
-
-
?
additional information
?
-
-
the enzyme hydrolyzes the peptide bond on the carboxyl side of internal proline residues of oligopeptide substrates with up to 30 amino acids, substrate specificity, overview
-
-
?
additional information
?
-
-
no activity with Ala-Pro-4-nitroanilide, Arg-Pro-4-nitroanilide, Val-Ala-4-nitroanilide, Gly-Pro-4-nitroanilide, Leu-4-nitroanilide, Pro-4-nitroanilide, Glu-4-nitroanilide, and Glu-Ala-4-nitroanilide
-
-
?
additional information
?
-
-
no activity with Ala-Pro-4-nitroanilide, Arg-Pro-4-nitroanilide, Val-Ala-4-nitroanilide, Gly-Pro-4-nitroanilide, Leu-4-nitroanilide, Pro-4-nitroanilide, Glu-4-nitroanilide, and Glu-Ala-4-nitroanilide
-
-
?
additional information
?
-
-
enzyme regulation, overview
-
-
?
additional information
?
-
-
cellular functions, overview
-
-
?
additional information
?
-
-
substrate specificity with exclusion of peptides with more than 30 amino acids, overview
-
-
?
additional information
?
-
-
the enzyme cleaves at the C-terminal side of proline residues, the bacterial enzyme is also capable of cleaving Ala-Xaa and Val-Xaa bonds, no activity with large proteins with over 30 amino acids
-
-
?
additional information
?
-
the enzyme cleaves the peptide bond on the C-terminal side of proline in peptides up to approx 30 residues, substrate entry into the active site cavity, substrate-binding structure and mechanism, the loops connecting the peptidase and propeller domains act like a hinge, holding the structure together as the domains move apart, creating a large opening, overview
-
-
?
additional information
?
-
-
the enzyme hydrolyzes the peptide bond on the carboxyl side of internal proline residues of oligopeptide substrates with up to 30 amino acids, substrate specificity, overview
-
-
?
additional information
?
-
ability to cleave immunotoxic gluten peptides endoproteolytically, attractive oral therapeutic candidates for protecting celiac sprue patients from the toxic effects of dietary gluten
-
-
?
additional information
?
-
-
cleavage of Pro-X bond
-
-
?
additional information
?
-
-
no hydrolysis of benzyloxycarbonyl-D-Pro-p-nitrophenol, negligibly small hydrolysis rate with benzyloxycarbonyl-D-Ala-Pro-p-nitrophenol
-
?
additional information
?
-
-
cellular functions, overview, POP may regulate phosphoinositide signaling, overview
-
-
?
additional information
?
-
-
substrate specificity with exclusion of peptides with more than 30 amino acids, overview
-
-
?
additional information
?
-
-
cellular functions, overview
-
-
?
additional information
?
-
-
substrate specificity with exclusion of peptides with more than 30 amino acids, overview
-
-
?
additional information
?
-
-
the enzyme cleaves the peptide bond on the C-terminal side of proline in peptides up to approx 30 residues, substrate entry into the active site cavity, substrate-binding structure and mechanism, general acid/base catalysis is the rate-limiting step, overview
-
-
?
additional information
?
-
-
the enzyme hydrolyzes the peptide bond on the carboxyl side of internal proline residues of oligopeptide substrates with up to 30 amino acids, substrate specificity, overview
-
-
?
additional information
?
-
-
tissue-dependent peptide hydrolysis evoked by prolyl endopeptidase activity is involved in the water-electrolyte homeostasis
-
?
additional information
?
-
-
cellular functions, overview, POP may regulate phosphoinositide signaling, overview
-
-
?
additional information
?
-
-
the enzyme in the brain dopaminergix system is involved in the pathogenesis of doamine deficiency-dependent depressive states, and is activated in association with development of MPTP-induced depressive syndrome in the brain frontal cortex, overview
-
-
?
additional information
?
-
-
the enzyme is a serine protease, that digests small peptide-like hormones, neuroactive peptides, and various cellular factors, it is implicated in several biological processes and diseases, e.g. in some psychiatric disorders, most probably through interference in the inositol cycle, it is important in the metabolism of substance P, arginine vasopressin, thyroliberin, and gonadoliberin, enzyme regulation, overview
-
-
?
additional information
?
-
-
the enzyme is associated with cognitive functions and inositol 1,4,5-triphosphate signaling, and plays a role in modifying neuropeptide levels, overview
-
-
?
additional information
?
-
-
the enzyme is involved in the phosphoinositide pathway, in formation and processing of amyloid beta-peptide, protein secretion, and in neuronal differentiation and maturation, overview, the enzyme is involved in several diseases, e.g. celiac disease, Alzheimer's diease, Parkinsons's disease, affective disorders, eating disorders, cancer, inflammation, hypertension, and neurodegenarative disorders, overview, enzyme inhibition can improve the retention time when administered before either the acquisition or the retential trial in scopolamine-induced amnesia, enzyme inhibition also positively affects neurodiseases, overview
-
-
?
additional information
?
-
-
the enzyme is involved with the inactivation of regulatory neuropeptides
-
-
?
additional information
?
-
-
the enzyme plays a role in inositol 1,4,5-triphosphate signaling and in the actions of antidepressants, POP inhibitors have antiamnesic and neuroprotective properties, overview
-
-
?
additional information
?
-
-
no activity with gluten in celiac sprue rats, substrate specificity with exclusion of peptides with more than 30 amino acids, overview
-
-
?
additional information
?
-
-
substrate specificity, overview, the enzyme cleaves at the C-terminal side of proline residues and more slowly of alanine residues, no activity with large proteins with over 30 amino acids
-
-
?
additional information
?
-
-
the enzyme hydrolyzes the peptide bond on the carboxyl side of internal proline residues of oligopeptide substrates with up to 30 amino acids, substrate specificity, overview
-
-
?
additional information
?
-
-
the enzyme shows endopeptidase activity with peptides no longer than 3 amino acids
-
-
?
additional information
?
-
-
the serine protease cleaves at the C-terminal side of proline residues and more slowly of alanine residues of peptides with no more than 30 amino acids
-
-
?
additional information
?
-
-
hydrolyzes proline-containing peptides shorter than 30 amino acids
-
-
?
additional information
?
-
-
is involved in thalamocortical and corticothalamic signal processing
-
-
?
additional information
?
-
prolyl oligopeptidase binds to the growth-38 associated protein GAP-43, which is a key regulator of synaptic plasticity
-
-
?
additional information
?
-
-
the recombinant prolyl oligopeptidase is not able to cleave whole 43-mer thymosin beta4, while it is effective at hydrolyzing somatostatin-28 (1-12)
-
-
?
additional information
?
-
no activity with Abz-L-Pro-L-Pro-4-nitrophenylalanine, Abz-L-Pro-L-Pro-L-Ala-4-nitrophenylalanine, Gly-L-Pro-7-amido-4-methylcoumarin, and L-Pro-7-amido-4-methylcoumarin
-
-
?
additional information
?
-
-
no activity with Abz-L-Pro-L-Pro-4-nitrophenylalanine, Abz-L-Pro-L-Pro-L-Ala-4-nitrophenylalanine, Gly-L-Pro-7-amido-4-methylcoumarin, and L-Pro-7-amido-4-methylcoumarin
-
-
?
additional information
?
-
no activity with human hemoglobin, human serum albumin, human collagen type I, and human collagen type IV
-
-
?
additional information
?
-
-
no activity with human hemoglobin, human serum albumin, human collagen type I, and human collagen type IV
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
substrate specificity, overview
-
-
?
additional information
?
-
-
cellular functions, overview, POP may regulate phosphoinositide signaling, overview
-
-
?
additional information
?
-
the enzyme is a serine protease, that digests small peptide-like hormones, neuroactive peptides, and various cellular factors, it is implicated in several biological processes and diseases, e.g. in some psychiatric disorders, most probably through interference in the inositol cycle, it is important in the metabolism of substance P, arginine vasopressin, thyroliberin, and gonadoliberin, enzyme regulation, overview
-
-
?
additional information
?
-
-
no activity with gluten in celiac sprue patients, substrate specificity with exclusion of peptides with more than 30 amino acids, overview
-
-
?
additional information
?
-
-
POP is a proline-specific peptidase that hydrolyzes oligopeptides after prolyl residues, the S1 binding site of POP has evolved to fit the pyrrolidine ring of an L-prolyl residue
-
-
?
additional information
?
-
substrate specificity, overview, the enzyme cleaves at the C-terminal side of proline residues and more slowly of alanine residues, no activity with large proteins with over 30 amino acids
-
-
?
additional information
?
-
-
the enzyme hydrolyzes the peptide bond on the carboxyl side of internal proline residues of oligopeptide substrates with up to 30 amino acids, substrate specificity, overview
-
-
?
additional information
?
-
-
stimulates the aggregation of alpha-synuclein
-
-
?
additional information
?
-
-
substance P, arginine-vasopressin, thyroliberin and gonadoliberin are proposed physiological substrates of this protease. No ZPP-sensitive cleavage occurred with the 33-mer, PEP-3, PEP-26, PEP-48_2, and PEP-50
-
-
?
additional information
?
-
substrates require a proline in position P1, with the exception of N-succinyl-L-Ala-L-Ala-L-Ala-7-amino-4-methylcoumarin
-
-
?
additional information
?
-
-
substrates require a proline in position P1, with the exception of N-succinyl-L-Ala-L-Ala-L-Ala-7-amino-4-methylcoumarin
-
-
?
additional information
?
-
-
enzyme inhibitors are able to prevent the in vitro invasion of rodent muscle cells by trypomastigotes
-
-
?
additional information
?
-
-
the enzyme cleaves the peptide bond on the C-terminal side of proline in peptides up to approx 30 residues, substrate entry into the active site cavity, substrate-binding structure and mechanism, overview
-
-
?
additional information
?
-
-
specifically hydrolyzes Pro-Xaa bonds, exerts a low specificity towards residues in position P1', except for Glu and P2 and does not cleave the proline bonds in long substrates such as ribonuclease
-
?
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((8'Z)-pentadecenyl)-salicylic acid
-
a noncompetitive inhibitor isolated from Gingko biloba leaves
(+)-gallocatechin
-
IC50: 0.000109 mM, expected to be useful for preventing and curing of Alzheimers disease
(-)-epicatechin
-
IC50: 0.0281 mM, noncompetitive inhibition
(-)-epicatechin 3-O-gallate
-
0.000052 mM, noncompetitive inhibition
(-)-epicatechin gallate
-
IC50: 10.2 mM, expected to be useful for preventing and curing of Alzheimers disease
(-)-epigallocatechin gallate
-
IC50: 0.000142 mM, expected to be useful for preventing and curing of Alzheimers disease
(1R,3S,4S,5S)-1,3,4-tris(acetyloxy)-5-([(2E)-3-[3,4-bis(acetyloxy)phenyl]prop-2-enoyl]oxy)cyclohexanecarboxylic acid
-
81.9% inhibition at 0.5 mM
(1R,3S,4S,5S)-3-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylic acid
-
88% inhibition at 0.5 mM
(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
-
93.8% inhibition at 0.5 mM
(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoic acid
-
29.4% inhibition at 0.5 mM
(2E)-3-(4-methoxyphenyl)prop-2-enoic acid
-
less than 10% inhibition at 0.5 mM
(2E)-3-phenylprop-2-enoic acid
-
16.1% inhibition at 0.5 mM
(2E)-3-[3,4-bis(acetyloxy)phenyl]prop-2-enoic acid
-
72.9% inhibition at 0.5 mM
(2R)-1-(1-[[3-(azepan-1-ylcarbonyl)phenyl]carbonyl]-L-prolyl)pyrrolidine-2-carbonitrile
50% inhibition at 4.6 nM
(2R)-1-(1-[[4-(pyrrolidin-1-ylcarbonyl)phenyl]carbonyl]-L-prolyl)pyrrolidine-2-carbonitrile
50% inhibition at 1.6 nM
(2R)-1-[1-(4-azepan-1-yl-4-oxobutanoyl)-L-prolyl]pyrrolidine-2-carbonitrile
50% inhibition at 0.76 nM
(2R)-1-[1-(4-oxo-4-pyrrolidin-1-ylbutanoyl)-L-prolyl]pyrrolidine-2-carbonitrile
50% inhibition at 2.9 nM
(2R)-1-[1-(5-azepan-1-yl-3,3-dimethyl-5-oxopentanoyl)-L-prolyl]pyrrolidine-2-carbonitrile
50% inhibition at 0.39 nM
(2R)-1-[1-(5-azepan-1-yl-5-oxopentanoyl)-L-prolyl]pyrrolidine-2-carbonitrile
50% inhibition at 1.2 nM
(2S)-1-(4-phenylbutanoyl)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidine
-
(2S)-1-({(2S,4S)-4-[2-(1,3-Dihydro-2H-isoindol-2-yl)-2-oxo- ethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4,4-difluoropyrrolidine-2- carbonitrile
-
potent and selective inhibitor of FAP, 0.01 mM used in assay conditions
(2S)-1-octanoyl-2-(pyrrolidin-1-ylcarbonyl)pyrrolidine
-
(2S)-1-[1-(2,3-dihydro-1H-inden-2-ylacetyl)-L-prolyl]pyrrolidine-2-carbaldehyde
-
-
(2S)-1-[1-(2,3-dihydro-1H-inden-2-ylacetyl)-L-prolyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[1-(3-[[(2S)-2-(cyclopentylcarbonyl)pyrrolidin-1-yl]carbonyl]benzoyl)-L-prolyl]pyrrolidine-2-carbonitrile
-
(2S)-1-[1-(4-phenylbutanoyl)-L-prolyl]pyrrolidine-2-carbaldehyde
-
(2S)-1-[1-(4-phenylbutanoyl)-L-prolyl]pyrrolidine-2-carbonitrile
-
(2S)-1-[1-[(3-[[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]carbonyl]phenyl)carbonyl]-D-prolyl]pyrrolidine-2-carbaldehyde
-
functional CHO group is the principal factor determining the inhibition kinetics
(2S)-1-[1-[(3-[[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]carbonyl]phenyl)carbonyl]-L-prolyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S)-1-(1-oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile
(2S,2'S)-1,1'-(benzene-1,3-diyldicarbonyl)bis[2-(pyrrolidin-1-ylcarbonyl)pyrrolidine]
-
-
(2S,3aS,7aS)-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]-2-(1,3-thiazolidin-3-ylcarbonyl)octahydro-1H-indole
-
S-17092
(3S)-3-(pyrrolidin-1-ylcarbonyl)-6-[[4-(trifluoromethyl)benzyl]oxy]-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-6-[(2,4-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-6-[(2,5-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-6-[(3,4-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-6-[(3,5-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-6-[(3,5-difluorobenzyl)oxy]-8-(phenylsulfonyl)-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-6-[(4-fluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-6-[(4-tert-butylbenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-6-[(4-tert-butylbenzyl)oxy]-8-(phenylsulfonyl)-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-(phenylsulfonyl)-3-(pyrrolidin-1-ylcarbonyl)-6-[[4-(trifluoromethyl)benzyl]oxy]-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-3-(pyrrolidin-1-ylcarbonyl)-6-(2,2,2-trifluoroethoxy)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-3-(pyrrolidin-1-ylcarbonyl)-6-[[4-(trifluoromethyl)benzyl]oxy]-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-(2-phenylethyl)-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-[(3,4-dichlorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-[(3,4-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-[(3,5-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-[(3-chloro-4-fluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-[(4-chlorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-[(4-fluorobenzyl)oxy]-3-(1H-pyrazol-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-[(4-fluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-[(4-methoxybenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-[2-(4-fluorophenyl)ethyl]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-N-benzyl-3-[[(2S)-2-(chloroacetyl)pyrrolidin-1-yl]carbonyl]-3,4-dihydroisoquinoline-2(1H)-carboxamide
-
(4R)-3-octanoyl-4-(pyrrolidin-1-ylcarbonyl)-1,3-thiazolidine
-
(5R,7S,8S,9S)-8,9-dihydroxy-2,2-dimethyl-4-oxo-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
-
88.3% inhibition at 0.5 mM
(6S)-1,3-dichloro-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-1-chloro-3-(cyclohexylmethoxy)-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-1-chloro-3-(naphthalen-2-ylmethoxy)-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-1-chloro-3-(pyridin-4-ylmethoxy)-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-1-chloro-3-phenoxy-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-1-chloro-3-[(2-phenylethyl)amino]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-1-chloro-3-[(3,4-dichlorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-1-chloro-3-[(3,4-difluorobenzyl)amino]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-1-chloro-3-[(3,4-difluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-1-chloro-3-[(3-chloro-4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-1-chloro-3-[(3-chlorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-1-chloro-3-[(4-fluorobenzyl)amino]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
(6S)-1-chloro-3-[2-(3,4-dichlorophenyl)ethoxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-1-chloro-3-[2-(4-fluorophenyl)ethoxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-1-chloro-6-(pyrrolidin-1-ylcarbonyl)-3-[(2,3,5-trifluorobenzyl)oxy]-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-1-chloro-6-(pyrrolidin-1-ylcarbonyl)-3-[[4-(trifluoromethyl)benzyl]oxy]-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-3-(benzylamino)-1-chloro-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(E)-1-(3-(4-methoxyphenyl)acryloyl)pyrrolidine-2-carboxylic acid
-
less than 10% inhibition at 0.5 mM
(E)-4-(3-(2-(methoxycarbonyl)pyrrolidin-1-yl)-3-oxoprop-1-enyl)-1,2-phenylene-diacetate
-
98.3% inhibition at 0.5 mM
(E)-methyl 1-(3-(3,4-dihydroxyphenyl)acryloyl)pyrrolidine-2-carboxylate
-
96.3% inhibition at 0.5 mM
(E)-methyl 1-(3-(3-(3,4-dihydroxyphenyl)acryloyloxy)-1,4,5-trihydroxycyclohexanecarbonyl)pyrrolidine-2-carboxylate
-
75.5% inhibition at 0.5 mM
(E)-methyl 1-(3-(4-methoxyphenyl)acryloyl)pyrrolidine-2-carboxylate
-
42.8% inhibition at 0.5 mM
(S)-1-((S)-1-(4-phenylbutanoyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
(S)-valinyl-(R)-boroproline
-
-
1,2,3,4,6-penta-O-galloyl-beta-D-glucose
-
IC50: 170 nM
1,2,3,4,6-pentagalloyl glucopyranoside
-
specific, noncompetitive, and strong inhibition
1,2,3,6-tetra-O-galloyl-beta-D-glucose
-
IC50: 25 nM
1,2,3,6-tetragalloyl alloside
-
specific, noncompetitive, and strong inhibition
1,2,3-trigalloyl glucopyranoside
-
specific, noncompetitive, and strong inhibition
1,2,6-tri-O-galloylglucose
-
IC50: 0.00044 mM, noncompetitive inhibition
1,2,6-trigalloyl alloside
-
specific, noncompetitive, and strong inhibition
1,2,6-trigalloyl glucopyranoside
-
from Euphorbia helioscopia, specific, noncompetitive, and strong inhibition
1,2-oxazolidin-2-yl[(2S,3aS,7aS)-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]octahydro-1H-indol-2-yl]methanone
-
-
1,3,6-trigalloyl alloside
-
specific, noncompetitive, and strong inhibition
1,3-dibenzyl-4-(benzylamino)-5-(methoxycarbonyl)-1H-3,1-benzimidazol-3-ium iodide
-
-
1,3-dicyclohexyl-4-(cyclohexylamino)-5-(methoxycarbonyl)-1H-3,1-benzimidazol-3-ium iodide
-
-
1-(2-(1-oxoisoindolin-2-acetyl))-(R)-boroproline
-
-
1-(3-oxo-3-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]propyl)-3-phenylquinoxalin-2(1H)-one
-
1-(4-oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]butyl)-3-phenylquinoxalin-2(1H)-one
-
1-(4-phenylbutanoyl)-2(S)-(pyridine-2-carbonyl)pyrrolidine
-
-
1-(4-phenylbutanoyl)-2(S)-(thiophene-2-carbonyl)pyrrolidin
-
-
1-(cyclopent-1-en-1-ylcarbonyl)-N-(2-phenylethyl)-L-prolinamide
-
1-(cyclopent-1-enecarbonyl)-D-proline benzylamide
-
-
1-(cyclopent-1-enecarbonyl)-L-proline benzylamide
-
-
1-(cyclopent-1-enecarbonyl)-L-proline phenethylamide
-
-
1-benzyl-3-cyclohexyl-4-(cyclohexylamino)-5-(methoxycarbonyl)-1H-3,1-benzimidazol-3-ium iodide
-
-
1-benzyl-3-cyclohexyl-4-(cyclohexylamino)-5-(methoxymethyl)-1H-3,1-benzimidazol-3-ium iodide
-
-
1-cinnamoylpyrrolidine-2-carboxylic acid
-
14.6% inhibition at 0.5 mM
1-[(2R,5S)-2-(propan-2-yl)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-4-(pyridin-3-yl)butan-1-one
-
1-[(2R,5S)-2-tert-butyl-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one
-
1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-2-[(2R)-1,2,3,4-tetrahydronaphthalen-2-yl]ethanone
-
-
1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-2-[(2S)-1,2,3,4-tetrahydronaphthalen-2-yl]ethanone
-
-
1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-4-(thiophen-2-yl)butan-1-one
-
-
1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]octan-1-one
-
-
1-[2-oxo-2-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]ethyl]-3-phenylquinoxalin-2(1H)-one
-
-
1-[[(2S)-1-(4-phenylbutanoyl)pyrrolidin-2-yl]carbonyl]pyrrolidin-2-one
-
-
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone
-
50% inhibition at 0.15 mM
2',4'-dihydroxy-6'-methoxy-3',5'-dimethyldihydrochalcone
-
50% inhibition at 0.098 mM
2',4'-dihydroxy-6'-methoxy-3'-methylchalcone
-
50% inhibition at 0.0375 mM
2',4'-dihydroxy-6'-methoxy-3'-methyldihydrochalcone
-
50% inhibition at 0.0125 mM
2'-hydroxy-4',6'-dimethoxy-3'-methylchalcone
-
50% inhibition above 0.2 mM
2'-hydroxy-4',6'-dimethoxy-3'-methyldihydrochalcone
-
50% inhibition at 0.158 mM
2(S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines
-
-
-
2(S)-(cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines
-
-
-
2(S)-(cyclohex-1-enecarbonyl)-1-(4-phenylbutanoyl)pyrrolidine
-
-
2(S)-(cyclopent-1-enecarbonyl)-1-(4-phenylbutanoyl)pyrrolidine
-
-
2(S)-(furan-2-carbonyl)-1-(4-phenylbutanoyl)pyrrolidine
-
-
2,3-dihydro-1H-inden-2-yl[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]methanone
-
-
2,3-dihydro-1H-pyrrol-1-yl[(2S,3aS,7aS)-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]octahydro-1H-indol-2-yl]methanone
-
-
2,5-dihydro-1H-pyrrol-1-yl[(2S,3aS,7aS)-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]octahydro-1H-indol-2-yl]methanone
-
-
2-(2,3-dihydro-1H-inden-2-yl)-1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]ethanone
-
-
2-(3-[(2S)-4,4-difluoro-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]-3-oxopropyl) isoindole-1,3(2H)-dione
-
2-(4-oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]butyl)-1H-isoindole-1,3(2H)-dione
-
2-hydroxy-1-[(2S)-1-[1-[(3-[[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]carbonyl]phenyl)carbonyl]-D-prolyl]pyrrolidin-2-yl]ethanone
-
functional CHO group is the principal factor determining the inhibition kinetics
2-oxo-kolavenic acid
-
terpenoid from the bark of Xylopia aethiopia, 34% inhibition at 1mM
2-[2-oxo-2-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]ethyl]-1H-isoindole-1,3(2H)-dione
-
-
2-[2-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
-
-
2-[3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl]-1H-isoindole-1,3(2H)-dione
-
3,3-dimethyl glutaric acid bis(L-prolyl-pyrrolidine) amide
-
IC50: 13 nM
3,5,4'-trihydroxystilbene 4'-O-beta-D-(2-O-galloyl)glucopyranoside
-
IC50: 0.003 mM, noncompetitive inhibition
3,5,4'-trihydroxystilbene 4'-O-beta-D-(6-O-galloyl)glucopyranoside
-
IC50: 0.0149 mM, noncompetitive inhibition
3,5,4'-trihydroxystilbene 4'-O-beta-D-glucopyranoside
-
IC50: 0.0229 mM, noncompetitive inhibition
3-(2(S)-benzoyl-pyrrolidine-1-carbonyl)-benzoyl-5(R)-tert-butyl-L-Pro-pyrrolidine
-
IC50: 460 nM
3-(2(S)-benzoyl-pyrrolidine-1-carbonyl)-benzoyl-L-Pro-pyrrolidine
-
IC50: 18 nM
3-(2,3-dihydro-1H-inden-2-yl)-1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propan-1-one
-
-
3-(3-oxo-3-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]propyl)-5,5-diphenylimidazolidine-2,4-dione
-
3-(4-oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]butyl)-5,5-diphenylimidazolidine-2,4-dione
-
3-({4-[2-(E)-styrylphenoxy]butanoyl}-L-4-hydroxyprolyl)-thiazolidine
-
SUAM-14746, selective prolyl oligopeptidase inhibitor
3-benzyl-4-(benzylamino)-5-(methoxycarbonyl)-1-methyl-1H-3,1-benzimidazol-3-ium iodide
-
-
3-cyclohexyl-4-(cyclohexylamino)-1-ethyl-5-[(prop-2-en-1-yloxy)carbonyl]-1H-3,1-benzimidazol-3-ium iodide
-
-
3-cyclohexyl-4-(cyclohexylamino)-1-methyl-5-[(prop-2-en-1-yloxy)carbonyl]-1H-3,1-benzimidazol-3-ium iodide
-
-
3-cyclohexyl-4-(cyclohexylamino)-5-(methoxycarbonyl)-1-(4-methylphenyl)-1H-3,1-benzimidazol-3-ium iodide
-
-
3-cyclohexyl-4-(cyclohexylamino)-5-(methoxycarbonyl)-1-methyl-1H-3,1-benzimidazol-3-ium iodide
-
-
3-cyclohexyl-4-(cyclohexylamino)-5-(methoxycarbonyl)-1-[(1S)-1-phenylethyl]-1H-3,1-benzimidazol-3-ium iodide
-
-
3-cyclohexyl-N-[(2S)-1-oxo-3-phenyl-1-[(2S)-2-(piperidin-1-ylcarbonyl)pyrrolidin-1-yl]propan-2-yl]propanamide
-
3-O-galloylepigallocatechin-(4-8)-epigallocetechin 3-O-gallate
-
IC50: 440 nM
3-[3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl]-5,5-diphenylimidazolidine-2,4-dione
-
-
33mer of gluten-derived peptide
-
-
4-(2,3-dihydro-1H-inden-2-yl)-1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]butan-1-one
-
-
4-(2-aminoethyl)-benzenesulfonyl fluoride
-
-
4-(2-aminoethyl)benzenesulfonyl fluoride
-
inhibition of extracellular isozyme
4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride
-
complete inhibition at 10 mM
4-(4-chlorophenyl)-8-(ethoxycarbonyl)-5-methyl-2,3-dihydrofuro[3,2-c]quinolin-5-ium iodide
-
-
4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(2,6-di-O-galloyl)glucopyranoside
-
IC50: 0.0105 mM, noncompetitive inhibition
4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside
-
IC50: 690 nM, noncompetitive inhibition
4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(6-O-galloyl-2-O-cinnamoyl)glucopyranoside
-
IC50: 0.082 mM, noncompetitive inhibition
4-(4-iodophenyl)butanoyl-L-prolyl-pyrrolidine
-
-
4-(4-[123I]iodophenyl)butanoyl-L-prolyl-2(S)-cyanopyrrolidine
-
-
4-([[(3S)-8-acetyl-5-oxo-3-(pyrrolidin-1-ylcarbonyl)-1,2,3,5-tetrahydroindolizin-6-yl]oxy]methyl)benzonitrile
-
-
4-chloromercuribenzoate
-
14% residual activity at 0.2 mM
4-Chloromercuriphenylsulfonate
4-hydroxymercuriphenylsulfonate
-
-
4-phenyl-1-[(2S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]butan-1-one
-
-
4-phenyl-1-[(2S)-2-[[(2S)-2-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-1-yl]carbonyl]pyrrolidin-1-yl]butan-1-one
-
4-phenyl-1-[(3S)-3-(pyrrolidin-1-ylcarbonyl)-3,4-dihydroisoquinolin-2(1H)-yl]butan-1-one
-
-
4-phenyl-1-[(4R)-4-(1,3-thiazolidin-3-ylcarbonyl)-1,3-thiazolidin-3-yl]butan-1-one
-
-
4-phenyl-1-[(4S)-4-(1,3-thiazolidin-3-ylcarbonyl)-1,3-thiazolidin-3-yl]butan-1-one
-
-
4-phenyl-1-[2-(pyrrolidin-1-ylcarbonyl)cyclopent-1-en-1-yl]butan-1-one
-
4-phenyl-1-[5-(pyrrolidin-1-ylcarbonyl)cyclopent-1-en-1-yl]butan-1-one
-
4-phenyl-butanoyl-L-prolyl-2(S)-cyanopyrrolidine
4-phenylbutanoyl-2(S)-(2-oxocyclopentanecarbonyl)-pyrrolidine
-
IC50: 260 nM
4-phenylbutanoyl-2(S)-(3-phenylpropionyl)pyrrolidine
-
IC50: 0.024 mM
4-phenylbutanoyl-2(S)-(cyclohexanecarbonyl)pyrrolidine
-
IC50: 1100 nM
4-phenylbutanoyl-2(S)-(cyclopentanecarbonyl)pyrrolidine
-
IC50: 30 nM
4-phenylbutanoyl-2(S)-(phenylacetyl)pyrrolidine
-
IC50: 3600 nM
4-phenylbutanoyl-2(S)-benzylpyrrolidine
-
IC50: 23 nM
4-phenylbutanoyl-2(S)-isobutanoylpyrrolidine
-
IC50: 620 nM
4-phenylbutanoyl-5(R)-methyl-L-Pro-2(S)-(hydroxyacetyl)pyrrolidine
-
IC50: 0.15 nM
4-phenylbutanoyl-5(R)-methyl-L-Pro-pyrrolidine
-
IC50: 0.71 nM
4-phenylbutanoyl-5(R)-t-butyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine
-
-
4-phenylbutanoyl-5(R)-t-butyl-L-prolyl-pyrrolidine
-
-
4-phenylbutanoyl-5(R)-tert-butyl-L-Pro-2(S)-(hydroxyacetyl)-pyrrolidine
-
IC50: 0.26 nM
4-phenylbutanoyl-5(R)-tert-butyl-L-Pro-pyrrolidine
-
IC50: 1.2 nM
4-phenylbutanoyl-5(R)-tert-butyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine
-
4-phenylbutanoyl-5(S)-methyl-L-Pro-pyrrolidine
-
IC50: 1.4 nM
4-phenylbutanoyl-L-Pro-2(S)-(hydroxyacetyl)-pyrrolidine
-
IC50: 0.24 nM
4-phenylbutanoyl-L-Pro-pyrrolidine
-
IC50: 2.2 nM
4-phenylbutanoyl-L-prolyl-2(S)-(cyclopentanecarbonyl)-pyrrolidine
-
IC%0: 1010 nM
4-phenylbutanoyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine
-
IC50: 0.2 nM
4-phenylbutanoyl-L-prolyl-2(S)-acetylpyrrolidine
-
IC50: 170 nM
4-phenylbutanoyl-L-prolyl-2(S)-benzoylpyrrolidine
-
IC50: 210 nM
4-phenylbutanoyl-L-prolyl-2(S)-cyanopyrrolidine
-
4-phenylbutanoyl-L-prolyl-2(S)cyanopyrrolidine
-
-
4-phenylbutanoyl-L-prolyl-pyrrolidine
-
i.e. SUAM-1221
4-toluenesulfonamide
-
98% residual activity at 0.2 mM
5,5'-dithio-bis(2-nitrobenzoic acid)
-
enzyme from brain
5,5'-dithio-bis-(2-nitrobenzoic acid)
-
complete inhibition at 5 mM
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5-(4-chlorophenyl)-9-(ethoxycarbonyl)-6-methyl-3,4-dihydro-2H-pyrano[3,2-c]quinolin-6-ium iodide
-
-
5-(methoxycarbonyl)-3-(4-methoxyphenyl)-4-[(4-methoxyphenyl)amino]-1-methyl-1H-3,1-benzimidazol-3-ium iodide
-
-
5-cyano-3-cyclohexyl-4-(cyclohexylamino)-1-methyl-1H-3,1-benzimidazol-3-ium iodide
-
-
6-((10'Z)-heptadecenyl)salicylic acid
-
a noncompetitive inhibitor isolated from Gingko biloba leaves
6-(10Z-heptadecenyl)salicylic acid
-
isolated from leaves of Ginkgo biloba, noncompetitive, 50% inhibition at 0.00062 mM
6-(8Z-pentadecenyl)salicylic acid
-
isolated from leaves of Ginkgo biloba, noncompetitive, 50% inhibition at 0.00086 mM
7-hydroxy-5-methoxy-6,8-dimethylflavanone
-
14% inhibition at 0.5 mM
8-(ethoxycarbonyl)-5-methyl-4-naphthalen-1-yl-2,3-dihydrofuro[3,2-c]quinolin-5-ium iodide
-
-
9-(ethoxycarbonyl)-6-methyl-5-phenyl-3,4-dihydro-2H-pyrano[3,2-c]quinolin-6-ium iodide
-
-
9H-fluoren-9-ylmethyl [(2S)-5-carbamimidamido-1-[(2S)-2-cyanopyrrolidin-1-yl]-1-oxopentan-2-yl]carbamate
-
-
acetonyl geraniin
-
specific, noncompetitive, and strong inhibition
acetyl-5(R)-tert-butyl-L-Pro-pyrrolidine
-
IC50: 7100 nM
adipic acid bis(L-prolyl-pyrrolidine) amide
-
IC50: 68 nM
AEBSF
1 mM, 12% inhibition
alpha-/beta-carotene
-
mixture of alpha- and beta-form, 64.4% inhibition at 0.5 mM
alpha-ketobenzothiazol
-
enzyme from serum
alpha2-gliadin 33-mer peptide
-
POP inhibitor
-
amastatin
-
0.1 mM, 97% inhibition
arachidonic acid
-
50% inhibition at 0.0534 mM
ARI-3099
-
i.e. N-(pyridine-4-carbonyl)-D-Ala-boro-L-Pro
ARI-3531
-
selective inhibitor, i.e. N-(pyridine-3-carbonyl)-L-Val-boroproline
Ba2+
-
48% residual activity at 10 mM
benzoyl-L-Pro-pyrrolidine
-
IC50: 66 nM
benzyl (1S,2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]cyclohexanecarboxylate
-
-
benzyl (2S)-2-(1,3-oxazolidin-3-ylcarbonyl)pyrrolidine-1-carboxylate
-
-
benzyl (2S)-2-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidine-1-carboxylate
-
-
benzyl (2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidine-1-carboxylate
-
-
benzyl (2S)-2-([(2S)-2-[(5-phenyl-4,5-dihydro-1,2-oxazol-3-yl)carbonyl]pyrrolidin-1-yl]carbonyl)pyrrolidine-1-carboxylate
-
benzyl (2S)-2-[(1-oxido-1,3-thiazolidin-3-yl)carbonyl]pyrrolidine-1-carboxylate
-
-
benzyl (2S)-2-[(2S)-2-formylpyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
-
-
benzyl (2S)-2-[[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate
benzyl (2S)-2-[[(2S)-2-([5-[(benzyloxy)methyl]-1,2-oxazol-3-yl]carbonyl)pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate
-
benzyl (2S)-2-[[(2S)-2-([5-[(benzyloxy)methyl]-4,5-dihydro-1,2-oxazol-3-yl]carbonyl)pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate
-
benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]-2,3-dihydro-1H-indole-1-carboxylate
-
-
benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]-5-oxopyrrolidine-1-carboxylate
-
-
benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate
benzyl trachyloban-19-oic acid
-
terpenoid from the bark of Xylopia aethiopia, 50% inhibition at 0.037 mM
benzyl [(2R)-1-[(2S)-2-cyanopyrrolidin-1-yl]-1-oxopropan-2-yl]carbamate
-
0.02 mM, more than 90% inhibition in extracts from brain-derived endothelial cells, extracts from astrocyte-derived cells and extracts from fibroblasts
benzyl [(2R,3R,7aS)-3-cyano-2-methyl-5-oxohexahydropyrrolo[2,1-b][1,3]oxazol-6-yl]carbamate
-
0.1 mM, 10-50% inhibition in extracts from astrocyte-derived cells and extracts from brain-derived endothelial cells, more than 50% inhibition in extracts from brain-derived endothelial cells
benzyl [(2S)-1-[(2S)-2-cyanopyrrolidin-1-yl]-1-oxopropan-2-yl]carbamate
-
0.02 mM, more than 90% inhibition in extracts from brain-derived endothelial cells, extracts from astrocyte-derived cells and extracts from fibroblasts
benzyl [(3R,6R,7aS)-3-cyano-5-oxohexahydropyrrolo[2,1-b][1,3]thiazol-6-yl]carbamate
benzyl [(3R,6R,8aS)-3-cyano-5-oxohexahydro-5H-[1,3]thiazolo[3,2-a]pyridin-6-yl]carbamate
-
0.1 mM, more than 50% inhibition in extracts from astrocyte-derived cells, extracts from brain-derived endothelial cells and extracts from fibroblasts
benzyl [(3R,6S,7aS)-3-cyano-5-oxohexahydropyrrolo[2,1-b][1,3]thiazol-6-yl]carbamate
-
0.1 mM, 10-50% inhibition in extracts from astrocyte-derived cells and extracts from brain-derived endothelial cells, more than 50% inhibition in extracts from brain-derived endothelial cells
benzyl [(3R,6S,8aS)-3-cyano-5-oxohexahydro-5H-[1,3]thiazolo[3,2-a]pyridin-6-yl]carbamate
-
0.1 mM, more than 50% inhibition in extracts from astrocyte-derived cells, extracts from brain-derived endothelial cells and extracts from fibroblasts
benzyl [(3R,7aS)-3-cyano-5-oxohexahydropyrrolo[2,1-b][1,3]oxazol-6-yl]carbamate
-
0.1 mM, 10-50% inhibition in extracts from fibroblasts
benzyl [(3S,6R,7aR)-3-cyano-5-oxohexahydropyrrolo[2,1-b][1,3]thiazol-6-yl]carbamate
-
0.1 mM, 10-50% inhibition in extracts from astrocyte-derived cells and extracts from brain-derived endothelial cells, more than 50% inhibition in extracts from brain-derived endothelial cells
benzyl [(3S,6S,7aR)-3-cyano-5-oxohexahydropyrrolo[2,1-b][1,3]thiazol-6-yl]carbamate
-
0.1 mM, 10-50% inhibition in extracts from astrocyte-derived cells and brain-derived endothelial cells
benzyl [(4S,7S,8aS)-4-cyano-6-oxohexahydro-2H-pyrrolo[2,1-b][1,3]thiazin-7-yl]carbamate
-
0.1 mM, 10-50% inhibition in extracts from fibroblasts
benzyl [2-(2-cyanopiperidin-1-yl)-2-oxoethyl]carbamate
-
0.1 mM, 10-50% inhibition in extracts from brain-derived endothelial cells and extracts from fibroblasts, more than 50% inhibition in extracts from astrocyte-derived cells
benzyl [2-[(2R)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]carbamate
-
0.02 mM, more than 90% inhibition in extracts from brain-derived endothelial cells, extracts from astrocyte-derived cells and extracts from fibroblasts
benzyl [2-[(2S)-2-(chloroacetyl)pyrrolidin-1-yl]-2-oxoethyl]carbamate
-
-
benzyl [2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]carbamate
-
0.02 mM, more than 90% inhibition in extracts from brain-derived endothelial cells, extracts from astrocyte-derived cells and extracts from fibroblasts
benzylcarbamoyl-5(R)-tert-butyl-L-prolyl-pyrrolidine
-
IC50: 2.0 nM
benzylcarbamoyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine
-
Benzyloxycarbonyl-Ala-Ala-Pro diazomethyl ketone
-
-
benzyloxycarbonyl-Gly-Gly-Pro-CH2Cl
-
enzyme from kidney
benzyloxycarbonyl-Gly-Pro-beta-naphthylamide
-
benzyloxycarbonyl-Gly-Pro-CH2Cl
benzyloxycarbonyl-L-methionyl-2(S)-cyanopyrrolidine
-
-
benzyloxycarbonyl-L-Pro-L-prolinal
-
IC50: 0.4 nM
benzyloxycarbonyl-Pro-L-prolinal
-
IC50: 0.33 nM
benzyloxycarbonyl-Pro-Pro-OH
-
-
benzyloxycarbonyl-Pro-prolinal
benzyloxycarbonyl-Pro-pyrrolidine
-
-
benzyloxycarbonyl-Pro-thiazolidine
-
-
benzyloxycarbonyl-proline-prolinal
benzyloxycarbonyl-prolyl-prolinal
-
-
benzyloxycarbonyl-thioPro-thiazolidine
-
-
benzyloxycarbonyl-thioPro-thioprolinal
-
-
benzyloxycarbonyl-thioprolyl-thioprolinal
-
specific inhibitor of prolyl oligopeptidase
benzyloxycarbonyl-thioprolylthiazolidine
-
-
benzyloxycarbonyl-thioprolylthioprolinal
-
enzyme from lymphocyte
betulin
-
50% inhibition at 0.101 mM
bixanin
-
specific and noncompetitive inhibition
Boc-5(R)-tert-butyl-L-Pro-pyrrolidine
-
IC50: 2.2 nM
Boc-5(S)-tert-butyl-L-Pro-pyrrolidine
-
IC50: 9.2 nM
Boc-L-Pro-pyrrolidine
-
IC50: 29 nM
buspirone
-
25% inhibition at 0.01 mM
calcitonin gene-related peptide
-
-
-
caproyl-L-Pro-((2S)-hydroxyacetyl)pyrrolidine
-
-
carbamazepine
-
mechanism, reverses the effect of drugs
Cbz-Pro-CN
-
0.1 mM, 10-50% inhibition in extracts from brain-derived endothelial cells
Cbz-Pro-NH2
-
0.1 mM, 10-50% inhibition in extracts from astrocyte-derived cells and extracts from fibroblasts
Chloromethylketone derivatives
chlorpromazine
-
55% inhibition at 0.01 mM
cis-3,5,4'-trihydroxystilbene 4'-O-beta-D-(6-O-galloyl)glucopyranoside
-
IC50: 0.0028 mM, noncompetitive inhibition
citalopram
-
27% inhibition at 0.01 mM
clozapine
-
40% inhibition at 0.01 mM
corilagin
-
specific, noncompetitive, and strong inhibition
cyclopent-2-ene-1,2-dicarboxylic acid 2-benzylamide 1-[2(S)-(hydroxyacetyl)-H-pyrrolidine]amide
-
cyclosporine A
-
the activating effect of methotrexate dominates the inhibitory effect of cyclosporine A
desipramine
-
20% inhibition at 0.01 mM
DFP
0.1 mM, 100% inhibition
diethyl dicarbonate
-
enzyme from brain
diisopropyl fluorophosphate
diisopropylfluorophosphate
diprotin
-
0.1 mM, complete inhibition
docosahexaenoic acid
-
50% inhibition at 0.0462 mM
duloxetine
-
21% inhibition at 0.01 mM
E-64
Lyophyllum cinerascens
-
-
eicosapentaenoic acid
-
50% inhibition at 0.0994 mM
elaeocarpusin
-
specific, noncompetitive, and strong inhibition
ent-kaur-16-en-19-oic acid
-
terpenoid from the bark of Xylopia aethiopia, 50% inhibition at 0.060 mM
epi-betulinic acid
-
50% inhibition at 0.015 mM
escitalopram
-
39% inhibition at 0.01 mM
euphorscopin
-
specific, noncompetitive, and strong inhibition
fluoxetine
-
an antidepressant
flupenthixol
-
56% inhibition at 0.01 mM
gallic acid 4-O-beta-D-(6-O-galloyl)glucopyranoside
-
IC50: 0.00939 mM, noncompetitive inhibition
geraniin
-
specific, noncompetitive, and strong inhibition
glutaric acid bis(L-prolyl-pyrrolidine) amide
-
IC50: 48 nM
glycinyl-(R)-boroproline
-
-
helioscopin B
-
specific, noncompetitive, and strong inhibition
helioscopinin A
-
specific, noncompetitive, and strong inhibition
helioscopinin B
-
specific, noncompetitive, and strong inhibition
hetero-chitooligosaccharides
-
hetero-chitooligosaccharides with different degrees of sulfatization, or deacetylation, preparation and inhibitory potency, competitive enzyme inhibition, overview
-
hispidulin
-
0.1 mM, 43% enzyme inhibition
imipramine
-
29% inhibition at 0.01 mM
interferon-alpha
-
IFN-alpha
-
isophthalic acid (L-proline methyl ester) L-prolyl-pyrrolidine amide
-
IC50: 54 nM
isophthalic acid 2(S)-(cyclopentanecarbonyl)pyrrolidine (L-proline methyl ester) amide
-
IC50: 640 nM
isophthalic acid 2(S)-(cyclopentanecarbonyl)pyrrolidine L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine amide
-
IC50: 0.61 nM, log P: 0.2, the log P value is a first prediction of the blood-brain barrier penetrability
isophthalic acid 2(S)-(cyclopentanecarbonyl)pyrrolidine-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine amide
-
-
isophthalic acid 2(S)-(cyclopentanecarbonyl)pyrrolidine-L-prolyl-2(S)-cyanopyrrolidine amide
-
-
isophthalic acid 2(S)-(cyclopentylcarbonyl)pyrrolidine L-prolyl-pyrrolidine amide
-
IC50: 14 nM, log P: 1.1, the log P value is a first prediction of the blood-brain barrier penetrability
isophthalic acid 2(S)-(cylcohexanecarbonyl)pyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide
-
IC50: 0.72 nM
isophthalic acid 2(S)-(cylcopentanecarbonyl)pyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide
-
IC50: 1.1 nM, log P: 0.8, the log P value is a first prediction of the blood-brain barrier penetrability
isophthalic acid 2(S)-acetylpyrrolidine L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine amide
-
IC50: 1.2 nM
isophthalic acid 2(S)-acetylpyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide
-
IC50: 4.2 nM, log P: -0.6, the log P value is a first prediction of the blood-brain barrier penetrability
isophthalic acid 2(S)-acetylpyrrolidine L-prolyl-pyrrolidine amide
-
IC50: 65 nM
isophthalic acid 2(S)-benzoylpyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide
-
IC50: 1.3 nM, log P: 1.1, the log P value is a first prediction of the blood-brain barrier penetrability
isophthalic acid 2(S)-benzoylpyrrolidine L-prolyl-pyrrolidine amide
-
IC50: 18 nM
isophthalic acid 2(S)-isobutanoylpyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide
-
IC50: 1.6 nM, log P: 0.3, the log P value is a first prediction of the blood-brain barrier penetrability
isophthalic acid bis(L-prolyl-pyrrolidine) amide
isophthalic acid bis-2(S)-(cyclopentanecarbonyl)pyrrolidine amide
-
IC50: 78 nM, log P: 2.7, the log P value is a first prediction of the blood-brain barrier penetrability
isophthalic acid bis-2(S)-acetylpyrrolidine amide
-
54% inhibition at 0.1 nM
isophthalic acid L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine L-prolyl-pyrrolidine amide
isophthalic acid L-prolyl-2(S)-cyanopyrrolidine L-prolyl-pyrrolidine amide
-
IC50: 1.5 nM
isophthalic acid L-prolyl-pyrrolidine L-prolyl-L-prolinal amide
-
IC50: 1.3 nM
isophthalic acid L-prolylbenzylamine L-prolyl-pyrrolidine amide
-
IC50: 31 nM
jolkinin
-
specific, noncompetitive, and strong inhibition
ketanserin
-
mixed type inhibitor, 49% inhibition at 0.01 mM
kolavenic acid
-
terpenoid from the bark of Xylopia aethiopia, 50% inhibition at 0.099 mM
L-1-tosylamido-2-phenylethylchloromethyl ketone
-
-
lamotrigine
-
22% inhibition at 0.01 mM
levomepromazine
-
32% inhibition at 0.01 mM
licuroside
-
IC50: 0.0265 mM, noncompetitive inhibition
linoleic acid
-
50% inhibition at 0.0438 mM
macranganin
-
from Euphorbia fisheriana, specific, noncompetitive, and strong inhibition
methyl (1R,3S,4S,5S)-3-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylate
-
92.6% inhibition at 0.5 mM
methyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
-
90.5% inhibition at 0.5 mM
methyl (2E)-3-(4-methoxyphenyl)prop-2-enoate
-
22% inhibition at 0.5 mM
methyl (2E)-3-phenylprop-2-enoate
-
20% inhibition at 0.5 mM
methyl (3R,6R,7aS)-6-[[(benzyloxy)carbonyl]amino]-5-oxohexahydropyrrolo[2,1-b][1,3]thiazole-3-carboxylate
-
0.1 mM, 10-50% inhibition in extracts from fibroblasts
methyl (3R,6S,7aS)-6-[[(benzyloxy)carbonyl]amino]-5-oxohexahydropyrrolo[2,1-b][1,3]thiazole-3-carboxylate
-
0.1 mM, 10-50% inhibition in extracts from astrocyte-derived cells and extracts from fibroblasts
methyl 1-cinnamoylpyrrolidine-2-carboxylate
-
less than 10% inhibition at 0.5 mM
methyl 2-(cyclohexylamino)-3-[cyclohexyl(formyl)amino]-4-(methylamino)benzoate
-
-
methyl 3-cyclohexyl-4-(cyclohexylamino)-1-methyl-2,3-dihydro-1H-benzimidazole-5-carboxylate
-
-
methyl trachyloban-19-oic acid
-
terpenoid from the bark of Xylopia aethiopia, 50% inhibition at 0.045 mM
mianserin
-
15% inhibition at 0.01 mM
N-(1-naphthalenecarbonyl)glycinyl-(R)-boroproline
-
-
N-(benzoyl)-(R)-alaninyl-(R)-boroproline
-
-
N-(pyridine-2-chloro-4-carbonyl)-(R)-alaninyl-(R)-boroproline
-
-
N-(pyridine-2-fluoro-4-carbonyl)-(R)-alaninyl-(R)-boroproline
-
-
N-(pyridine-3-carbonyl)-(R)-alaninyl-(R)-boroproline
-
-
N-(pyridine-3-carbonyl)glycinyl-(R)-boroproline
-
-
N-(pyridine-3-chloro-4-carbonyl)-(R)-alaninyl-(R)-boroproline
-
-
N-(pyridine-3-fluoro-4-carbonyl)-(R)-alaninyl-(R)-boroproline
-
-
N-(pyridine-4-carbonyl)glycinyl-(R)-boroproline
-
-
N-(quinoline-4-carbonyl)-(R)-alaninyl-(R)-boroproline
-
-
N-(quinoline-4-carbonyl)-(R)-butyl(glycinyl)-(R)-boroproline
-
-
N-(quinoline-4-carbonyl)-(R)-ethyl(glycinyl)-(R)-boroproline
-
-
N-(quinoline-4-carbonyl)-(R)-methioninyl-(R)-boroproline
-
-
N-(quinoline-4-carbonyl)-(R)-phenyl(glycinyl)-(R)-boroproline
-
-
N-(quinoline-4-carbonyl)-(R)-propyl(glycinyl)-(R)-boroproline
-
-
N-(quinoline-4-carbonyl)-(R)-serinyl-(R)-boroproline
-
-
N-acetyl-(R)-alaninyl-(R)-boroproline
-
-
N-Alpha-benzyloxycarbonyl-Ala-Pro
-
-
N-benzyloxycarbonyl-L-prolyl-L-prolinal
-
i.e. Z-Pro-prolinal
N-benzyloxycarbonyl-thioprolyl-thioprolinaldimethylacetal
-
-
N-Benzyloxycarbonyl-valyl-prolinal
-
-
N-carbobenzoxy-Leu-Leu-Leu-COH
-
the proteasome inhibitor
N-carbobenzoxy-prolyl-prolinal
-
ZPP
N-methyllaurotetanine
-
-
N-p-tosyl-L-phenylalanine chloromethylketone
67.2% inhibition at 0.001 mM
N-p-tosyl-L-phenylalanine-chloromethylketone
-
-
N-[(2S)-1-[(2S)-2-formylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-4-phenylbutanamide
-
-
N-[(2S)-3-methyl-1-oxo-1-[(2S)-2-(piperidin-1-ylcarbonyl)pyrrolidin-1-yl]butan-2-yl]-3-phenoxybenzamide
-
Nalpha-tosyl-L-lysine chloromethylketone
38.3% inhibition at 0.001 mM
Nalpha-tosyl-L-lysine-chloromethylketone
-
-
orinithine decarboxylase
-
-
-
oroxylin A
-
0.1 mM, 20% enzyme inhibition
oroxyloside
-
0.1 mM, 34% enzyme inhibition
p-hydroxymercuribenzoate
-
-
Pancreatic basic trypsin inhibitor
-
-
-
PCMBS
-
enzyme from kidney
phenyl (2S)-2-(((2S)-2-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-1-yl)carbonyl)pyrrolidine-1-carboxylate
-
phenyl (2S)-2-(((2S)-2-(isoxazol-3-ylcarbonyl)pyrrolidin-yl)carbonyl)pyrrolidine-1-carboxylate
-
phenyl (2S)-2-([(2S)-2-[(5-phenylisoxazol-3-yl)carbonyl]pyrrolidin-1-yl]carbonyl)pyrrolidine-1-carboxylate
-
phenyl (2S)-2-[[(2S)-2-([5-[(2E)-3-phenylprop-2-en-1-yl]isoxazol-3-yl]carbonyl)pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate
50% inhibition at 0.01 mM, inhibition of parasite invasion into host cells
phenyl (2S)-2-[[(2S)-2-[[5-(trimethylsilyl)isoxazol-3-yl]carbonyl]pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate
-
phenylmethanesulfonyl fluoride
-
PE and POP are partially resistant to phenylmethanesulfonyl fluoride, a generic serine protease inhibitor that has a low efficiency in inhibiting POP
phenylmethylsulfonyl fluoride
phthalic acid bis(L-prolyl-pyrrolidine) amide
-
IC50: 0.021 mM
pimozide
-
11% inhibition at 0.01 mM
prazosin
-
91% inhibition at 0.01 mM
prochlorperazine
-
77% inhibition at 0.01 mM
promazine
-
64% inhibition at 0.01 mM
propeptin
-
a netural inhibitor of POP isolated from Microbispora sp. strain SNA-115
puromycin
-
0.1 mM, 97% inhibition
reboxetine
-
13% inhibition at 0.01 mM
reserpine
-
18% inhibition at 0.01 mM
rhodionin
-
IC50: 0.022 mM
rhodiosin
-
IC50: 0.041 mM
risperidone
-
56% inhibition at 0.01 mM
ritanserin
-
33% inhibition at 0.01 mM
rugosin E
-
from Euphorbia supina, specific, noncompetitive, and strong inhibition
salicylic acid
-
50% inhibition at 1.65 mM
Sn2+
-
87% residual activity at 0.2 mM
Soybean trypsin inhibitor
-
succinic acid bis(L-prolyl-pyrrolidine) amide
-
IC50: 77 nM
supinanin
-
specific, noncompetitive, and strong inhibition
teracatain
-
specific, noncompetitive, and strong inhibition
terephthalic acid bis(L-prolyl-pyrrolidine) amide
-
IC50: 81 nM
tert-butyl (2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidine-1-carboxylate
-
tert-butyl [(2S)-3-methyl-1-(1,3-thiazolidin-3-yl)-1-thioxobutan-2-yl]carbamate
-
-
thioridazine
-
non-competitive inhibitor, 91% inhibition at 0.01 mM
TLCK
0.1 mM, 73.2% inhibition
tosyllysylchloromethane
-
enzyme from brain
tosylphenylalanylchloromethane
-
enzyme from brain, partly
TPCK
0.1 mM, 91.1% inhibition
trachyloban-19-oic acid
-
terpenoid from the bark of Xylopia aethiopia, 50% inhibition at 0.164 mM
Tyr-Pro-Ile-Pro-Phe
-
inhibitory peptide isolated from grapes of Cabernet Sauvignon
Val-Glu-Ile-Pro-Glu
-
inhibitory peptide isolated from grapes of Cabernet Sauvignon
Valproate
-
competitive inhibitor, 56% inhibition at 0.5 mM
Z-Ala-Pro-chloromethylketone
Z-Arg-Pro-chloromethylketone
Z-L-Pro-prolinal
-
50% inhibition at 0.0000022 mM
Z-L-prolyl-L-prolinal
-
-
Z-Pro-Pro-aldehyde-dimethyl acetal
-
Z-Pro-Pro-aldehyde-dimethylacetal
Z-Pro-Pro-dimethyl acetal aldehyde
-
irreversible inhibitor
Z-thioprolyl-thioprolinal-dimethylacetal
-
physiological effects, overview
[(1R,2R)-2-phenylcyclopropyl][(2S,3aS,7aS)-2-(1,3-thiazolidin-3-ylcarbonyl)octahydro-1H-indol-1-yl]methanone
-
-
[(1R,2R)-2-phenylcyclopropyl][(2S,3aS,7aS)-2-(1H-pyrrol-1-ylcarbonyl)octahydro-1H-indol-1-yl]methanone
-
-
[(1R,2R)-2-phenylcyclopropyl][(2S,3aS,7aS)-2-(pyrrolidin-1-ylcarbonyl)octahydro-1H-indol-1-yl]methanone
-
-
[(1R,2R)-2-phenylcyclopropyl][(3S)-3-(pyrrolidin-1-ylcarbonyl)-2-azabicyclo[2.2.2]oct-2-yl]methanone
-
-
[(2R)-1-[N-(2,5-dichlorobenzoyl)glycyl]pyrrolidin-2-yl]boronic acid
-
-
(2S)-1-[[(2S)-1-(1-oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile
i.e. KYP-2047, hyperbolic kinetics of KYP-2047 binding to human PREP with pseudo-firstorder rate constant, Van't Hoff plot for binding of KYP-2047 to human PREP, a covalent bond is formed between the nitrile group of KYP-2047 and the active site serine
(2S)-1-[[(2S)-1-(1-oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile
i.e. KYP-2047
(6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
is co-crystallized within the catalytic site of a human chimeric POP protein which provides a more detailed understanding of how these inhibitors interact with the key residues within the catalytic pocket
(6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(S)-1-((S)-1-(4-phenylbutanoyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
-
KYP-2047, most potent inhibitor
(S)-1-((S)-1-(4-phenylbutanoyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
-
KYP-2047, most potent inhibitor
1,10-phenanthroline
Lyophyllum cinerascens
-
-
1,10-phenanthroline
-
about 59% inhibition at 10 mM
3,4-dichloroisocoumarin
-
enzyme from lymphocyte
3,4-dichloroisocoumarin
-
-
3,4-dichloroisocoumarin
77.3% inhibition at 0.1 mM
4-Chloromercuriphenylsulfonate
-
not
4-Chloromercuriphenylsulfonate
-
-
4-Chloromercuriphenylsulfonate
-
-
4-Chloromercuriphenylsulfonate
-
weak
4-Chloromercuriphenylsulfonate
-
-
4-phenyl-butanoyl-L-prolyl-2(S)-cyanopyrrolidine
-
KYP-2047
4-phenyl-butanoyl-L-prolyl-2(S)-cyanopyrrolidine
-
KYP-204, 0.1 mM and 0.5 mM concentrations significantly inhibit enzyme activity in tissue homogenate
aesculitannin B
-
noncompetitive
aesculitannin B
-
noncompetitive
Al3+
-
65% residual activity at 10 mM
Al3+
-
34.5% residual activity at 1 mM
antipain
-
-
antipain
32.4% inhibition at 0.02 mM
Aprotinin
-
89% residual activity at 1 mM
Aprotinin
-
inhibition of extracellular isozyme
Aprotinin
1.4% inhibition at 0.05 mM
bacitracin
-
-
bacitracin
-
50% inhibition at 0.129 mM
bacitracin
-
50% inhibition at 0.130 mM
benzamidine
-
-
benzamidine
3.7% inhibition at 0.01 mM
benzamidine
1 mM, 7.2% inhibition
benzyl (2S)-2-[[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate
-
-
benzyl (2S)-2-[[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate
-
-
benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate
-
-
benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate
-
-
benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate
-
-
benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate
-
-
benzyl [(3R,6R,7aS)-3-cyano-5-oxohexahydropyrrolo[2,1-b][1,3]thiazol-6-yl]carbamate
-
0.02 mM, more than 90% inhibition in extracts from brain-derived endothelial cells, extracts from astrocyte-derived cells and extracts from fibroblasts
benzyl [(3R,6R,7aS)-3-cyano-5-oxohexahydropyrrolo[2,1-b][1,3]thiazol-6-yl]carbamate
-
-
benzyloxycarbonyl-Gly-Pro-CH2Cl
-
-
benzyloxycarbonyl-Gly-Pro-CH2Cl
Ascidia sp.
-
-
benzyloxycarbonyl-Gly-Pro-CH2Cl
-
-
benzyloxycarbonyl-Gly-Pro-CH2Cl
Lyophyllum cinerascens
-
-
benzyloxycarbonyl-Gly-Pro-CH2Cl
-
enzyme from kidney and brain
benzyloxycarbonyl-Gly-Pro-CH2Cl
-
benzyloxycarbonyl-Pro-prolinal
-
-
benzyloxycarbonyl-Pro-prolinal
-
benzyloxycarbonyl-Pro-prolinal
-
i.e. Z-Pro-prolinal
benzyloxycarbonyl-Pro-prolinal
-
i.e. Z-Pro-prolinal
benzyloxycarbonyl-Pro-prolinal
-
-
benzyloxycarbonyl-Pro-prolinal
-
i.e. Z-Pro-Prolinal, inhibition of cytsolic isozyme, but no inhibition of the extracellular isozyme in serum
benzyloxycarbonyl-Pro-prolinal
-
-
benzyloxycarbonyl-Pro-prolinal
Lyophyllum cinerascens
-
-
benzyloxycarbonyl-Pro-prolinal
-
-
benzyloxycarbonyl-Pro-prolinal
-
i.e. Z-Pro-prolinal
benzyloxycarbonyl-Pro-prolinal
-
-
benzyloxycarbonyl-Pro-prolinal
-
i.e. Z-Pro-prolinal
benzyloxycarbonyl-Pro-prolinal
-
-
benzyloxycarbonyl-Pro-prolinal
-
-
benzyloxycarbonyl-Pro-prolinal
-
i.e. Z-Pro-prolinal
benzyloxycarbonyl-Pro-prolinal
i.e. Z-Pro-prolinal
benzyloxycarbonyl-Pro-prolinal
-
benzyloxycarbonyl-proline-prolinal
-
specific inhibition
benzyloxycarbonyl-proline-prolinal
-
specific inhibition
benzyloxycarbonyl-proline-prolinal
specific inhibition
benzyloxycarbonyl-proline-prolinal
-
specific inhibition
benzyloxycarbonyl-proline-prolinal
-
specific inhibition
bestatin
-
-
bestatin
-
0.5 mM, 97% inhibition
bestatin
2.3% inhibition at 0.001 mM
Boc-Asn-Phe-Pro-aldehyde
-
Boc-Asn-Phe-Pro-aldehyde
-
-
Boc-Asn-Phe-Pro-aldehyde
-
-
Ca2+
-
-
Ca2+
83.9% residual activity at 1 mM
Cd2+
-
enzyme from lymphocyte
Cd2+
-
complete inhibition at 0.05 mM
Chloromethylketone derivatives
-
-
Chloromethylketone derivatives
-
-
Chloromethylketone derivatives
-
-
Chloromethylketone derivatives
-
-
Co2+
-
48% residual activity at 0.2 mM
Co2+
-
enzyme from lymphocyte
Cu2+
-
12% residual activity at 1 mM
Cu2+
-
14.1% residual activity at 1 mM
Cu2+
-
13% residual activity at 0.2 mM
Cu2+
-
enzyme from lymphocyte
Cu2+
-
57% residual activity at 1 mM
Cu2+
91.2% residual activity at 1 mM
diisopropyl fluorophosphate
-
-
diisopropyl fluorophosphate
Ascidia sp.
-
-
diisopropyl fluorophosphate
-
enzyme from hypophysis, eye-lens and brain
diisopropyl fluorophosphate
-
-
diisopropyl fluorophosphate
-
13% residual activity at 0.2 mM
diisopropyl fluorophosphate
-
-
diisopropyl fluorophosphate
-
enzyme from brain, lymphocyte and serum
diisopropyl fluorophosphate
-
-
diisopropyl fluorophosphate
Lyophyllum cinerascens
-
-
diisopropyl fluorophosphate
-
-
diisopropyl fluorophosphate
-
-
diisopropyl fluorophosphate
-
enzyme from kidney and brain
diisopropyl fluorophosphate
-
enzyme from brain and skin
diisopropyl fluorophosphate
complete inhibition at 0.1 mM
diisopropyl fluorophosphate
-
enzyme from brain and muscle
diisopropyl fluorophosphate
-
-
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
-
dithiothreitol
-
-
dithiothreitol
-
86% residual activity at 5 mM
E64
-
-
E64
6.5% inhibition at 0.01 mM
EDTA
-
37.3% residual activity at 10 mM
EDTA
-
93% residual activity at 0.2 mM
EDTA
Lyophyllum cinerascens
-
-
EDTA
-
94% residual activity at 1 mM
EDTA
3.8% inhibition at 1 mM
EDTA
91.2% residual activity at 30 mM
epicatechin
-
noncompetitive
epicatechin
-
noncompetitive
Fe2+
-
55% residual activity at 10 mM
Fe2+
-
80.6% residual activity at 1 mM
Hg2+
-
enzyme from hypophysis and brain
Hg2+
-
complete inhibition at 0.2 mM
Hg2+
-
enzyme from lymphocyte
Hg2+
Lyophyllum cinerascens
-
-
Hg2+
-
complete inhibition at 0.05 mM
iodoacetamide
-
enzyme from brain
iodoacetamide
-
87% residual activity at 0.2 mM
iodoacetamide
-
enzyme from kidney
iodoacetamide
-
enzyme from brain
iodoacetamide
-
23.61% residual activity at 10 mM
iodoacetate
Lyophyllum cinerascens
-
-
iodoacetate
-
enzyme from brain
iodoacetate
98.3% residual activity at 1 mM
isolinderalactone
-
competitive
isolinderalactone
-
competitive
isophthalic acid bis(L-prolyl-pyrrolidine) amide
-
IC50: 26 nM
isophthalic acid bis(L-prolyl-pyrrolidine) amide
-
IC50: 26 nM, log O = -0.2, the log P value is a first prediction of the blood-brain barrier penetrability
isophthalic acid L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine L-prolyl-pyrrolidine amide
-
0.00039 nM
isophthalic acid L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine L-prolyl-pyrrolidine amide
-
IC50: 0.39 nM
JTP-4819
-
-
JTP-4819
-
i.e. (S)-2-[[(S)-2-(hydroxyacetyl)-1-yrrolidinyl]carbonyl]-N-(phenylmethyl)-1-pyrrolidinecarboxamide
JTP-4819
-
a selective POP inhibitor, physiological effects, overview
JTP-4819
-
used the tight-binding inhibitor JTP-4819 covalently coupled with fluorescein (FJTP) as a tool to study the changes on expression and localization of POP protein
JTP-4819
-
i.e. (S)-2-[[(S)-2-(hydroxyacetyl)-1-pyrrolidinyl]carbonyl]-N(phenylmethyl)-1-pyrrolidinecarboxamide
JTP-4819
-
i.e. (S)-2-[[(S)-2-(hydroxyacetyl)-1-yrrolidinyl]carbonyl]-N-(phenylmethyl)-1-pyrrolidinecarboxamide
JTP-4819
-
a selective POP inhibitor, physiological effects, overview
JTP-4819
-
a selective POP inhibitor, physiological effects, overview
JTP-4819
-
i.e. (S)-2-[[(S)-2-(hydroxyacetyl)-1-yrrolidinyl]carbonyl]-N-(phenylmethyl)-1-pyrrolidinecarboxamide, improves learning deficits in rats with dorsal hippocampal lesions
JTP-4819
-
a selective POP inhibitor, physiological effects, overview
JTP-4819
-
a selective POP inhibitor, physiological effects, overview
K+
-
92.2% residual activity at 1 mM
K+
-
63% residual activity at 1 mM
K+
88.8% residual activity at 1 mM
KYP-2047
-
i.e. 4-phenylbutanoyl-L-prolyl-2(S)cyanopyrrolidine
KYP-2047
-
i.e. 4-phenylbutanoyl-l-prolyl-2(S)-cyanopyrrolidine, highly potent covalent reversible competitive inhibitor
KYP-2047
-
i.e. 4-phenylbutanoyl-L-prolyl-(2S)-cyanopyrrolidine
KYP-2047
-
selective inhibitor, i.e (2S)-1[(2S)-1-(1-oxo-4-phenylbutyl)-2-pyrrolidinylcarbonyl]-2-pyrrolidinecarbonitrile
KYP-2047
-
specific inhibitor, complete inhibition at 0.06 mM
KYP-2047
-
i.e. 4-phenylbutanoyl-l-prolyl-2(S)-cyanopyrrolidine
leupeptin
-
86% residual activity at 1 mM
leupeptin
2.3% inhibition at 0.02 mM
leupeptin
0.1 mM, 46.2% inhibition
linderalactone
-
competitive
linderalactone
-
competitive
linderene
-
competitive
linderene acetate
-
competitive
linderene acetate
-
competitive
lithium
-
reverses the effect of the drugs
lithium
-
mechanism, reverses the effect of drugs
lupeol
-
50% inhibition at 0.065 mM
lupeol
-
0.1 mM, 5% enzyme inhibition
Mg2+
-
97% residual activity at 10 mM
Mg2+
-
87.3% residual activity at 1 mM
Mg2+
-
87% residual activity at 1 mM
Mg2+
90.1 % residual activity at 1 mM
Mn2+
-
30% residual activity at 10 mM
Mn2+
-
24.3% residual activity at 1 mM
Mn2+
-
93% residual activity at 0.2 mM
Mn2+
-
87% residual activity at 1 mM
Mn2+
90.4% residual activity at 1 mM
N-ethylmaleimide
-
-
N-ethylmaleimide
-
50% residual activity at 0.2 mM
N-ethylmaleimide
-
complete inhibition at 10 mM
Na+
-
93.1% residual activity at 1 mM
Na+
92.3% residual activity at 1 mM
NEM
-
enzyme from hypophysis and eye-lens
NEM
-
enzyme from brain and skin
Ni2+
-
86% residual activity at 0.2 mM
Ni2+
-
58% residual activity at 0.05 mM
o-phenanthroline
-
79% residual activity at 0.2 mM
oleic acid
-
50% inhibition at 0.031 mM
oleic acid
-
50% inhibition at 0.0236 mM
ONO-1603
-
-
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
PCMB
-
-
PCMB
-
enzyme from lymphocyte
PCMB
Lyophyllum cinerascens
-
-
PCMB
-
enzyme from kidney and brain
PCMB
-
enzyme from brain and skin
PCMB
0.1 mM, 98% inhibition
Pefabloc SC
-
-
Pefabloc SC
12% inhibition at 1 mM
pepstatin A
-
-
pepstatin A
7.3% inhibition at 0.001 mM
phenylmethylsulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
-
97% residual activity at 1 mM
phenylmethylsulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
-
18% residual activity at 1 mM
phenylmethylsulfonyl fluoride
-
-
phenylmethylsulfonyl fluoride
47.6% inhibition at 1 mM
phenylmethylsulfonyl fluoride
96% residual activity at 1 mM
PMSF
Ascidia sp.
-
-
PMSF
-
enzyme from lymphocyte
PMSF
Lyophyllum cinerascens
-
-
PMSF
-
enzyme from brain and partly enzyme from skin
PMSF
1 mM, 18% inhibition
rosmarinic acid
-
non-competitive inhibitor
S 17092
-
selective enzyme inhibitor, pharmacodynamics and pharmacokinetics, overview
S 17092
-
physiological effects, overview
S 17092
-
selective enzyme inhibitor, pharmacodynamics and pharmacokinetics, overview
S 17092
-
physiological effects, overview
S 17092
-
physiological effects, overview
S 17092
-
selective enzyme inhibitor, pharmacodynamics and pharmacokinetics, overview
S 17092
-
physiological effects, overview
S 17092
-
physiological effects, overview
S-17092
-
-
S-17092
-
i.e. (2S,3aS,7aS)-1-[(R,R)-2-phenylcyclopropyl]-2-[(thiazolidin-3-yl)carbonyl]octahydro-1H-indole, specific enzyme inhibitor
S-17092
-
i.e. (2S,3aS,7aS)-1-[[(R,R)-2-phenylcyclopropyl]carbonyl]-2-[(thiazolidin-3-yl)carbonyl] octahydro-1H-indole
S-17092
-
i.e. (2S,3aS,7aS)-1-[[(R,R)-2-phenylcyclopropyl]carbonyl]-2-[(thiazolidin-3-yl)carbonyl] octahydro-1H-indole
S-17092
-
i.e. (2S,3aS,7aS)-1-[[(R,R)-2-phenylcyclopropyl]carbonyl]-2-[(thiazolidin-3-yl)carbonyl] octahydro-1H-indole
Soybean trypsin inhibitor
-
-
-
Soybean trypsin inhibitor
12.3% inhibition at 0.01 mM
-
SUAM 14746
-
i.e. 3-([4-[2-(E)-styrylphenoxy]butanoyl]-L-4-hydroxyprolyl)thiazolidine
SUAM 14746
i.e. 3-([4-[2-(E)-styrylphenoxy]butanoyl]-L-4-hydroxyprolyl)thiazolidine
SUAM-1221
-
-
SUAM-14746
-
-
SUAM-14746
-
specific inhibitor, complete inhibition at 0.03 mM
UAMC-00021
-
-
Valproic acid
-
reverses the effect of the drugs
Valproic acid
-
mechanism, reverses the effect of drugs
Valproic acid
-
an antimanic drug
Y-29794 oxalate
-
-
Z-Ala-Pro-aldehyde
-
-
Z-Ala-Pro-chloromethylketone
-
-
Z-Ala-Pro-chloromethylketone
complete inhibition at 0.001 mM
Z-Arg-Pro-aldehyde
-
-
Z-Arg-Pro-chloromethylketone
-
-
Z-Arg-Pro-chloromethylketone
-
Z-Gly-Pro-aldehyde
-
-
Z-Lys-Pro-aldehyde
-
-
Z-Pro
-
-
Z-Pro
41.1% inhibition at 0.1 mM
Z-Pro-Pro
-
-
Z-Pro-Pro
37.6% inhibition at 0.1 mM
Z-Pro-Pro-aldehyde
-
-
Z-Pro-Pro-aldehyde
complete inhibition at 0.001 mM
Z-Pro-Pro-aldehyde-dimethylacetal
-
-
Z-Pro-Pro-aldehyde-dimethylacetal
-
-
Z-Pro-prolinal
-
-
Z-Pro-prolinal
-
a transition state analog inhibitor, binding structure
Z-Pro-prolinal
-
30% residual activity at 0.1 mM
Z-Pro-prolinal
-
a transition state analog inhibitor, binding structure
Z-Pro-prolinal
-
physiological effects, overview
Z-Pro-prolinal
-
specific inhibitor
Z-Pro-prolinal
-
with high potency but relatively poor stability
Z-Tyr-Pro-aldehyde
-
-
Zn2+
-
91% residual activity at 10 mM
Zn2+
-
31.2% residual activity at 1 mM
Zn2+
-
61% residual activity at 0.2 mM
Zn2+
-
enzyme from lymphocyte
Zn2+
91.3% residual activity at 1 mM
ZTTA
-
i.e. N-benzyloxycarbonyl-thioprolyl-thioprolinal-dimethylacetal
ZTTA
-
i.e. N-benzyloxycarbonyl-thioprolyl-thioprolinal-dimethylacetal
ZTTA
-
i.e. N-benzyloxycarbonyl-thioprolyl-thioprolinal-dimethylacetal
additional information
-
the enzyme is completely resistant to digestion with pepsin
-
additional information
-
-
-
additional information
-
different N-blocked L-proline-containing compounds and derivatives
-
additional information
-
-
-
additional information
-
structure-function relationship of inhibitors, specificity at the P2 and S3 position, overview
-
additional information
-
comparison of inhibitory effects of methylchalcones on enzyme, trypsin and thrombin
-
additional information
-
-
-
additional information
-
structure-function relationship of inhibitors, specificity at the P2 and S3 position, overview
-
additional information
-
endogenous inhibitor
-
additional information
-
resistant to: PMSF, thyorphan, E64 and phosphoramidon
-
additional information
-
at least 3 galloyl groups are required for strong inhibition activity by Euphorbiaceae plants, poor inhibition by 1-galloyl glucopyranoside, 1,6-digalloyl glucopyranoside, 2,6-digalloyl glucopyranoside, 2-galloyl galactose, 6-galloyl-1-O-(4-gallate)-glucopyranoside, 6-galloyl-1-O-(phloroglucinol)-glucopyranoside, gallic acid, furosin, anthricin, gomisin A, tigloyl gomisin, 8-C-(glucopyranosyl)-kaempferol, 3-O-galloyl shikimate, 4-O-galloyl shikimate, 3-O-(2-galloyl-glucopyranosyl)-quercetin, quercetin-3-O-glucopyranoside, alpha-viniferin, 5-O-galloylquininc acid, and shizarin, overview
-
additional information
-
no inhibition by lithium, carbamazepime, desipramine, fluoxetine, and olanzapine
-
additional information
-
structure-function relationship of inhibitors, specificity at the P2 and S3 position, overview
-
additional information
-
not inhibited by cyclosporine A
-
additional information
-
not inhibited by huperzine A
-
additional information
-
-
-
additional information
-
no inhibition by lithium, carbamazepime, desipramine, fluoxetine, and olanzapine
-
additional information
-
structure-function relationship of inhibitors, specificity at the P2 and S3 position, overview
-
additional information
-
inhibitor binding structure
-
additional information
-
not inhibited by p-aminobenzamidine, 1,10-phenanthroline and 2-mercaptoethanol
-
additional information
-
no effect by SH-reagents and metal chelators
-
additional information
-
structure-function relationship of inhibitors, specificity at the P2 and S3 position, overview
-
additional information
-
-
-
additional information
-
no inhibition by lithium, carbamazepime, desipramine, fluoxetine, and olanzapine
-
additional information
-
structure-function relationship of inhibitors, specificity at the P2 and S3 position, overview
-
additional information
-
not inhibited by carbamazepine, bupropion, diazepam, fluoxetine, haloperidol, lithium, maprotiline, mirtazapine, moclobemide, pargyline, pinoline, scopolamine, selegiline, sulpiride, venlafaxine, and valpraote at 0.01 mM concentration
-
additional information
-
not diisopropyl fluorophosphate, p-chloromercuriphenylsulfonic acid
-
additional information
-
inhibitor synthesis, overview
-
additional information
structure-function relationship of inhibitors, specificity at the P2 and S3 position, overview
-
additional information
-
specific dipeptidyl peptidase IV inhibitor HIV-1 tat (1-9) fragment with sequence H-Met-Asp-Pro-Val-Asp-Pro-Asn-Ile-Glu-OH
-
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0.000109
(+)-gallocatechin
Elizabethkingia meningoseptica
-
IC50: 0.000109 mM, expected to be useful for preventing and curing of Alzheimers disease
0.0281
(-)-epicatechin
Elizabethkingia meningoseptica
-
IC50: 0.0281 mM, noncompetitive inhibition
10.2
(-)-epicatechin gallate
Elizabethkingia meningoseptica
-
IC50: 10.2 mM, expected to be useful for preventing and curing of Alzheimers disease
0.000142
(-)-epigallocatechin gallate
Elizabethkingia meningoseptica
-
IC50: 0.000142 mM, expected to be useful for preventing and curing of Alzheimers disease
0.0989
(1R,3S,4S,5S)-1,3,4-tris(acetyloxy)-5-([(2E)-3-[3,4-bis(acetyloxy)phenyl]prop-2-enoyl]oxy)cyclohexanecarboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.023
(1R,3S,4S,5S)-3-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.0125
(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.198
(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.028
(2E)-3-[3,4-bis(acetyloxy)phenyl]prop-2-enoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.00003
(2S)-1-(4-phenylbutanoyl)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidine
Sus scrofa
-
0.000048
(2S)-1-octanoyl-2-(pyrrolidin-1-ylcarbonyl)pyrrolidine
Sus scrofa
-
0.00000045
(2S)-1-[1-(2,3-dihydro-1H-inden-2-ylacetyl)-L-prolyl]pyrrolidine-2-carbaldehyde
Canis lupus familiaris
-
brain
0.0000012
(2S)-1-[1-(2,3-dihydro-1H-inden-2-ylacetyl)-L-prolyl]pyrrolidine-2-carbonitrile
Canis lupus familiaris
-
brain
0.0000087
(2S)-1-[1-(4-phenylbutanoyl)-L-prolyl]pyrrolidine-2-carbaldehyde
Sus scrofa
kidney
0.000000023
(2S)-1-[1-(4-phenylbutanoyl)-L-prolyl]pyrrolidine-2-carbonitrile
Sus scrofa
-
0.000002
(2S,3aS,7aS)-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]-2-(1,3-thiazolidin-3-ylcarbonyl)octahydro-1H-indole
Homo sapiens
-
-
0.000034
(3S)-3-(pyrrolidin-1-ylcarbonyl)-6-[[4-(trifluoromethyl)benzyl]oxy]-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.000031
(3S)-6-[(2,4-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.000064
(3S)-6-[(2,5-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.000018
(3S)-6-[(3,4-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.000022
(3S)-6-[(3,5-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.000004
(3S)-6-[(3,5-difluorobenzyl)oxy]-8-(phenylsulfonyl)-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.000022
(3S)-6-[(4-fluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.00006
(3S)-6-[(4-tert-butylbenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.00027
(3S)-6-[(4-tert-butylbenzyl)oxy]-8-(phenylsulfonyl)-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.000011
(3S)-8-(phenylsulfonyl)-3-(pyrrolidin-1-ylcarbonyl)-6-[[4-(trifluoromethyl)benzyl]oxy]-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.000584
(3S)-8-acetyl-3-(pyrrolidin-1-ylcarbonyl)-6-(2,2,2-trifluoroethoxy)-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.000028
(3S)-8-acetyl-3-(pyrrolidin-1-ylcarbonyl)-6-[[4-(trifluoromethyl)benzyl]oxy]-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.000002
(3S)-8-acetyl-6-(2-phenylethyl)-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.000028
(3S)-8-acetyl-6-[(3,4-dichlorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.000007
(3S)-8-acetyl-6-[(3,4-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.000022
(3S)-8-acetyl-6-[(3,5-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.000008
(3S)-8-acetyl-6-[(3-chloro-4-fluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.000048
(3S)-8-acetyl-6-[(4-chlorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.000343
(3S)-8-acetyl-6-[(4-fluorobenzyl)oxy]-3-(1H-pyrazol-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.000053
(3S)-8-acetyl-6-[(4-fluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.00014
(3S)-8-acetyl-6-[(4-methoxybenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.00003
(3S)-8-acetyl-6-[2-(4-fluorophenyl)ethyl]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
Homo sapiens
-
-
0.000002
(3S)-N-benzyl-3-[[(2S)-2-(chloroacetyl)pyrrolidin-1-yl]carbonyl]-3,4-dihydroisoquinoline-2(1H)-carboxamide
Trypanosoma brucei brucei
-
0.000011
(4R)-3-octanoyl-4-(pyrrolidin-1-ylcarbonyl)-1,3-thiazolidine
Sus scrofa
-
0.0143
(5R,7S,8S,9S)-8,9-dihydroxy-2,2-dimethyl-4-oxo-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
Homo sapiens
-
pH and temperature not specified in the publication
0.0031
(6S)-1,3-dichloro-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
Homo sapiens
-
-
0.000007
(6S)-1-chloro-3-(cyclohexylmethoxy)-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
Homo sapiens
-
-
0.004
(6S)-1-chloro-3-(naphthalen-2-ylmethoxy)-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
Homo sapiens
-
-
0.0008
(6S)-1-chloro-3-(pyridin-4-ylmethoxy)-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
Homo sapiens
-
-
0.001
(6S)-1-chloro-3-phenoxy-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
Homo sapiens
-
-
0.00008
(6S)-1-chloro-3-[(2-phenylethyl)amino]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
Homo sapiens
-
-
0.000034
(6S)-1-chloro-3-[(3,4-dichlorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
Homo sapiens
-
-
0.000015
(6S)-1-chloro-3-[(3,4-difluorobenzyl)amino]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
Homo sapiens
-
-
0.000055
(6S)-1-chloro-3-[(3,4-difluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
Homo sapiens
-
-
0.000043
(6S)-1-chloro-3-[(3-chloro-4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
Homo sapiens
-
-
0.00003
(6S)-1-chloro-3-[(3-chlorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
Homo sapiens
-
-
0.000017
(6S)-1-chloro-3-[(4-fluorobenzyl)amino]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
Homo sapiens
-
-
0.000012 - 0.00004
(6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
0.0022
(6S)-1-chloro-3-[2-(3,4-dichlorophenyl)ethoxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
Homo sapiens
-
-
0.0009
(6S)-1-chloro-3-[2-(4-fluorophenyl)ethoxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
Homo sapiens
-
-
0.00004
(6S)-1-chloro-6-(pyrrolidin-1-ylcarbonyl)-3-[(2,3,5-trifluorobenzyl)oxy]-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
Homo sapiens
-
-
0.00025
(6S)-1-chloro-6-(pyrrolidin-1-ylcarbonyl)-3-[[4-(trifluoromethyl)benzyl]oxy]-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
Homo sapiens
-
-
0.000012
(6S)-3-(benzylamino)-1-chloro-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
Homo sapiens
-
-
0.12
(E)-4-(3-(2-(methoxycarbonyl)pyrrolidin-1-yl)-3-oxoprop-1-enyl)-1,2-phenylene-diacetate
Homo sapiens
-
pH and temperature not specified in the publication
0.1057
(E)-methyl 1-(3-(3,4-dihydroxyphenyl)acryloyl)pyrrolidine-2-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.21
(E)-methyl 1-(3-(3-(3,4-dihydroxyphenyl)acryloyloxy)-1,4,5-trihydroxycyclohexanecarbonyl)pyrrolidine-2-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.00000029 - 0.00001
(S)-1-((S)-1-(4-phenylbutanoyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
0.00017
1,2,3,4,6-penta-O-galloyl-beta-D-glucose
Flavobacterium sp.
-
IC50: 170 nM
0.000025
1,2,3,6-tetra-O-galloyl-beta-D-glucose
Flavobacterium sp.
-
IC50: 25 nM
0.00044
1,2,6-tri-O-galloylglucose
Elizabethkingia meningoseptica
-
IC50: 0.00044 mM, noncompetitive inhibition
0.0000314
1,2,6-trigalloyl glucopyranoside
Homo sapiens
-
-
0.000002
1,2-oxazolidin-2-yl[(2S,3aS,7aS)-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]octahydro-1H-indol-2-yl]methanone
Rattus norvegicus
-
rat cortex
0.051
1,3-dibenzyl-4-(benzylamino)-5-(methoxycarbonyl)-1H-3,1-benzimidazol-3-ium iodide
Homo sapiens
-
-
0.214
1,3-dicyclohexyl-4-(cyclohexylamino)-5-(methoxycarbonyl)-1H-3,1-benzimidazol-3-ium iodide
Homo sapiens
-
-
0.00000088
1-(3-oxo-3-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]propyl)-3-phenylquinoxalin-2(1H)-one
Sus scrofa
-
0.000059
1-(4-oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]butyl)-3-phenylquinoxalin-2(1H)-one
Sus scrofa
-
0.00051
1-(4-phenylbutanoyl)-2(S)-(pyridine-2-carbonyl)pyrrolidine
Sus scrofa
-
pH 7.0, 30°C
0.000003
1-(4-phenylbutanoyl)-2(S)-(thiophene-2-carbonyl)pyrrolidin
Sus scrofa
-
pH 7.0, 30°C
0.00011
1-(cyclopent-1-en-1-ylcarbonyl)-N-(2-phenylethyl)-L-prolinamide
Sus scrofa
brain
0.044
1-(cyclopent-1-enecarbonyl)-D-proline benzylamide
Sus scrofa
-
pH 7.0, 30°C
0.00021
1-(cyclopent-1-enecarbonyl)-L-proline benzylamide
Sus scrofa
-
pH 7.0, 30°C
0.0001
1-(cyclopent-1-enecarbonyl)-L-proline phenethylamide
Sus scrofa
-
pH 7.0, 30°C
0.122
1-benzyl-3-cyclohexyl-4-(cyclohexylamino)-5-(methoxycarbonyl)-1H-3,1-benzimidazol-3-ium iodide
Homo sapiens
-
-
0.037
1-benzyl-3-cyclohexyl-4-(cyclohexylamino)-5-(methoxymethyl)-1H-3,1-benzimidazol-3-ium iodide
Homo sapiens
-
-
0.0000021
1-[(2R,5S)-2-(propan-2-yl)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-4-(pyridin-3-yl)butan-1-one
Sus scrofa
brain
0.0000012
1-[(2R,5S)-2-tert-butyl-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one
Sus scrofa
brain
0.000054
1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-2-[(2R)-1,2,3,4-tetrahydronaphthalen-2-yl]ethanone
Canis lupus familiaris
-
brain
0.0000054
1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-2-[(2S)-1,2,3,4-tetrahydronaphthalen-2-yl]ethanone
Canis lupus familiaris
-
brain
0.000034
1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-4-(thiophen-2-yl)butan-1-one
Canis lupus familiaris
-
brain
0.00002
1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]octan-1-one
Rattus norvegicus
-
rat brain
0.00000088
1-[2-oxo-2-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]ethyl]-3-phenylquinoxalin-2(1H)-one
Rattus norvegicus
-
rat brain
0.0571
1-[[(2S)-1-(4-phenylbutanoyl)pyrrolidin-2-yl]carbonyl]pyrrolidin-2-one
Canis lupus familiaris
-
brain
0.000059
2(S)-(cyclohex-1-enecarbonyl)-1-(4-phenylbutanoyl)pyrrolidine
Sus scrofa
-
pH 7.0, 30°C
0.000003
2(S)-(cyclopent-1-enecarbonyl)-1-(4-phenylbutanoyl)pyrrolidine
Sus scrofa
-
pH 7.0, 30°C
0.0000052
2(S)-(furan-2-carbonyl)-1-(4-phenylbutanoyl)pyrrolidine
Sus scrofa
-
pH 7.0, 30°C
0.00052
2,3-dihydro-1H-inden-2-yl[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]methanone
Canis lupus familiaris
-
brain
0.0000027
2,3-dihydro-1H-pyrrol-1-yl[(2S,3aS,7aS)-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]octahydro-1H-indol-2-yl]methanone
Rattus norvegicus
-
rat cortex
0.0000024
2,5-dihydro-1H-pyrrol-1-yl[(2S,3aS,7aS)-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]octahydro-1H-indol-2-yl]methanone
Rattus norvegicus
-
rat cortex
0.00001
2-(2,3-dihydro-1H-inden-2-yl)-1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]ethanone
Canis lupus familiaris
-
brain
0.00000081
2-(3-[(2S)-4,4-difluoro-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]-3-oxopropyl) isoindole-1,3(2H)-dione
Sus scrofa
-
0.00004
2-(4-oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]butyl)-1H-isoindole-1,3(2H)-dione
Sus scrofa
-
0.000003
2-[2-oxo-2-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]ethyl]-1H-isoindole-1,3(2H)-dione
Rattus norvegicus
-
rat brain
0.00000081
2-[2-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
Rattus norvegicus
-
rat brain
0.000003
2-[3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl]-1H-isoindole-1,3(2H)-dione
Sus scrofa
-
0.000013
3,3-dimethyl glutaric acid bis(L-prolyl-pyrrolidine) amide
Sus scrofa
-
IC50: 13 nM
0.003
3,5,4'-trihydroxystilbene 4'-O-beta-D-(2-O-galloyl)glucopyranoside
Elizabethkingia meningoseptica
-
IC50: 0.003 mM, noncompetitive inhibition
0.0149
3,5,4'-trihydroxystilbene 4'-O-beta-D-(6-O-galloyl)glucopyranoside
Elizabethkingia meningoseptica
-
IC50: 0.0149 mM, noncompetitive inhibition
0.0229
3,5,4'-trihydroxystilbene 4'-O-beta-D-glucopyranoside
Elizabethkingia meningoseptica
-
IC50: 0.0229 mM, noncompetitive inhibition
0.00046
3-(2(S)-benzoyl-pyrrolidine-1-carbonyl)-benzoyl-5(R)-tert-butyl-L-Pro-pyrrolidine
Sus scrofa
-
IC50: 460 nM
0.000018
3-(2(S)-benzoyl-pyrrolidine-1-carbonyl)-benzoyl-L-Pro-pyrrolidine
Sus scrofa
-
IC50: 18 nM
0.000036
3-(2,3-dihydro-1H-inden-2-yl)-1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propan-1-one
Canis lupus familiaris
-
brain
0.000041
3-(4-oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]butyl)-5,5-diphenylimidazolidine-2,4-dione
Sus scrofa
-
0.147
3-benzyl-4-(benzylamino)-5-(methoxycarbonyl)-1-methyl-1H-3,1-benzimidazol-3-ium iodide
Homo sapiens
-
-
0.129
3-cyclohexyl-4-(cyclohexylamino)-1-ethyl-5-[(prop-2-en-1-yloxy)carbonyl]-1H-3,1-benzimidazol-3-ium iodide
Homo sapiens
-
-
0.14
3-cyclohexyl-4-(cyclohexylamino)-1-methyl-5-[(prop-2-en-1-yloxy)carbonyl]-1H-3,1-benzimidazol-3-ium iodide
Homo sapiens
-
-
0.194
3-cyclohexyl-4-(cyclohexylamino)-5-(methoxycarbonyl)-1-(4-methylphenyl)-1H-3,1-benzimidazol-3-ium iodide
Homo sapiens
-
-
0.072
3-cyclohexyl-4-(cyclohexylamino)-5-(methoxycarbonyl)-1-methyl-1H-3,1-benzimidazol-3-ium iodide
Homo sapiens
-
-
0.169
3-cyclohexyl-4-(cyclohexylamino)-5-(methoxycarbonyl)-1-[(1S)-1-phenylethyl]-1H-3,1-benzimidazol-3-ium iodide
Homo sapiens
-
-
0.00000107
3-cyclohexyl-N-[(2S)-1-oxo-3-phenyl-1-[(2S)-2-(piperidin-1-ylcarbonyl)pyrrolidin-1-yl]propan-2-yl]propanamide
Sus scrofa
kidney
0.00044
3-O-galloylepigallocatechin-(4-8)-epigallocetechin 3-O-gallate
Flavobacterium sp.
-
IC50: 440 nM
0.000041
3-[3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl]-5,5-diphenylimidazolidine-2,4-dione
Rattus norvegicus
-
rat brain
0.00006
4-(2,3-dihydro-1H-inden-2-yl)-1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]butan-1-one
Canis lupus familiaris
-
brain
0.065 - 0.133
4-(4-chlorophenyl)-8-(ethoxycarbonyl)-5-methyl-2,3-dihydrofuro[3,2-c]quinolin-5-ium iodide
0.0105
4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(2,6-di-O-galloyl)glucopyranoside
Elizabethkingia meningoseptica
-
IC50: 0.0105 mM, noncompetitive inhibition
0.00069
4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside
Elizabethkingia meningoseptica
-
IC50: 690 nM, noncompetitive inhibition
0.082
4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(6-O-galloyl-2-O-cinnamoyl)glucopyranoside
Elizabethkingia meningoseptica
-
IC50: 0.082 mM, noncompetitive inhibition
0.000783
4-([[(3S)-8-acetyl-5-oxo-3-(pyrrolidin-1-ylcarbonyl)-1,2,3,5-tetrahydroindolizin-6-yl]oxy]methyl)benzonitrile
Homo sapiens
-
-
1
4-phenyl-1-[(2S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]butan-1-one
Bos taurus
-
brain, value above
0.000005
4-phenyl-1-[(2S)-2-[[(2S)-2-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-1-yl]carbonyl]pyrrolidin-1-yl]butan-1-one
Sus scrofa
kidney
0.00055
4-phenyl-1-[(3S)-3-(pyrrolidin-1-ylcarbonyl)-3,4-dihydroisoquinolin-2(1H)-yl]butan-1-one
Homo sapiens
-
-
0.000021
4-phenyl-1-[(4R)-4-(1,3-thiazolidin-3-ylcarbonyl)-1,3-thiazolidin-3-yl]butan-1-one
Canis lupus familiaris
-
brain
0.102
4-phenyl-1-[(4S)-4-(1,3-thiazolidin-3-ylcarbonyl)-1,3-thiazolidin-3-yl]butan-1-one
Canis lupus familiaris
-
brain
0.00023
4-phenyl-1-[2-(pyrrolidin-1-ylcarbonyl)cyclopent-1-en-1-yl]butan-1-one
Sus scrofa
brain
0.0000013
4-phenyl-1-[5-(pyrrolidin-1-ylcarbonyl)cyclopent-1-en-1-yl]butan-1-one
Sus scrofa
brain
0.00026
4-phenylbutanoyl-2(S)-(2-oxocyclopentanecarbonyl)-pyrrolidine
Sus scrofa
-
IC50: 260 nM
0.024
4-phenylbutanoyl-2(S)-(3-phenylpropionyl)pyrrolidine
Sus scrofa
-
IC50: 0.024 mM
0.0011
4-phenylbutanoyl-2(S)-(cyclohexanecarbonyl)pyrrolidine
Sus scrofa
-
IC50: 1100 nM
0.00003
4-phenylbutanoyl-2(S)-(cyclopentanecarbonyl)pyrrolidine
Sus scrofa
-
IC50: 30 nM
0.0036
4-phenylbutanoyl-2(S)-(phenylacetyl)pyrrolidine
Sus scrofa
-
IC50: 3600 nM
0.000023
4-phenylbutanoyl-2(S)-benzylpyrrolidine
Sus scrofa
-
IC50: 23 nM
0.00062
4-phenylbutanoyl-2(S)-isobutanoylpyrrolidine
Sus scrofa
-
IC50: 620 nM
0.00000015
4-phenylbutanoyl-5(R)-methyl-L-Pro-2(S)-(hydroxyacetyl)pyrrolidine
Sus scrofa
-
IC50: 0.15 nM
0.00000071
4-phenylbutanoyl-5(R)-methyl-L-Pro-pyrrolidine
Sus scrofa
-
IC50: 0.71 nM
0.00000026
4-phenylbutanoyl-5(R)-tert-butyl-L-Pro-2(S)-(hydroxyacetyl)-pyrrolidine
Sus scrofa
-
IC50: 0.26 nM
0.0000012
4-phenylbutanoyl-5(R)-tert-butyl-L-Pro-pyrrolidine
Sus scrofa
-
IC50: 1.2 nM
0.00000026
4-phenylbutanoyl-5(R)-tert-butyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine
Sus scrofa
at 25°C between pH 5.5 and 9.5
0.0000014
4-phenylbutanoyl-5(S)-methyl-L-Pro-pyrrolidine
Sus scrofa
-
IC50: 1.4 nM
0.00000024
4-phenylbutanoyl-L-Pro-2(S)-(hydroxyacetyl)-pyrrolidine
Sus scrofa
-
IC50: 0.24 nM
0.0000022
4-phenylbutanoyl-L-Pro-pyrrolidine
Sus scrofa
-
IC50: 2.2 nM
0.0000002
4-phenylbutanoyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine
Sus scrofa
-
IC50: 0.2 nM
0.00017
4-phenylbutanoyl-L-prolyl-2(S)-acetylpyrrolidine
Sus scrofa
-
IC50: 170 nM
0.00021
4-phenylbutanoyl-L-prolyl-2(S)-benzoylpyrrolidine
Sus scrofa
-
IC50: 210 nM
0.0000002
4-phenylbutanoyl-L-prolyl-2(S)-cyanopyrrolidine
Sus scrofa
at 25°C between pH 5.5 and 9.5
0.124
5-(4-chlorophenyl)-9-(ethoxycarbonyl)-6-methyl-3,4-dihydro-2H-pyrano[3,2-c]quinolin-6-ium iodide
Homo sapiens
-
-
0.099
5-(methoxycarbonyl)-3-(4-methoxyphenyl)-4-[(4-methoxyphenyl)amino]-1-methyl-1H-3,1-benzimidazol-3-ium iodide
Homo sapiens
-
-
0.201
5-cyano-3-cyclohexyl-4-(cyclohexylamino)-1-methyl-1H-3,1-benzimidazol-3-ium iodide
Homo sapiens
-
-
0.075
8-(ethoxycarbonyl)-5-methyl-4-naphthalen-1-yl-2,3-dihydrofuro[3,2-c]quinolin-5-ium iodide
Homo sapiens
-
-
0.135
9-(ethoxycarbonyl)-6-methyl-5-phenyl-3,4-dihydro-2H-pyrano[3,2-c]quinolin-6-ium iodide
Homo sapiens
-
-
0.0071
acetyl-5(R)-tert-butyl-L-Pro-pyrrolidine
Sus scrofa
-
IC50: 7100 nM
0.000068
adipic acid bis(L-prolyl-pyrrolidine) amide
Sus scrofa
-
IC50: 68 nM
0.337
argemonine
Homo sapiens
-
at pH 7.4 and 37°C
0.013
ARI-3099
Homo sapiens
-
at 25°C, pH not specified in the publication
0.0000013
ARI-3531
Homo sapiens
-
at 25°C, pH not specified in the publication
0.0123
Baicalin
Homo sapiens
-
-
0.000066
benzoyl-L-Pro-pyrrolidine
Sus scrofa
-
IC50: 66 nM
0.00000034
benzyl (2S)-2-([(2S)-2-[(5-phenyl-4,5-dihydro-1,2-oxazol-3-yl)carbonyl]pyrrolidin-1-yl]carbonyl)pyrrolidine-1-carboxylate
Trypanosoma brucei brucei
-
4.9
benzyl (2S)-2-[(2S)-2-formylpyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.014
benzyl (2S)-2-[[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate
Homo sapiens
-
human peripheral blood mononuclear cells
0.0000021
benzyl (2S)-2-[[(2S)-2-([5-[(benzyloxy)methyl]-1,2-oxazol-3-yl]carbonyl)pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate
Trypanosoma brucei brucei
-
0.0000014
benzyl (2S)-2-[[(2S)-2-([5-[(benzyloxy)methyl]-4,5-dihydro-1,2-oxazol-3-yl]carbonyl)pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate
Trypanosoma brucei brucei
-
0.000002
benzylcarbamoyl-5(R)-tert-butyl-L-prolyl-pyrrolidine
Sus scrofa
-
IC50: 2.0 nM
0.00000083
benzylcarbamoyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine
Sus scrofa
at 25°C between pH 5.5 and 9.5
0.0000004
benzyloxycarbonyl-L-Pro-L-prolinal
Sus scrofa
-
IC50: 0.4 nM
0.00000033
benzyloxycarbonyl-Pro-L-prolinal
Sus scrofa
-
IC50: 0.33 nM
0.128
berberine chloride
Setaria cervi
-
at pH 8.0 and 37°C
0.0231
bixanin
Homo sapiens
-
-
0.0000022
Boc-5(R)-tert-butyl-L-Pro-pyrrolidine
Sus scrofa
-
IC50: 2.2 nM
0.0000092
Boc-5(S)-tert-butyl-L-Pro-pyrrolidine
Sus scrofa
-
IC50: 9.2 nM
0.00204 - 0.00294
Boc-Asn-Phe-Pro-aldehyde
0.000029
Boc-L-Pro-pyrrolidine
Sus scrofa
-
IC50: 29 nM
0.6028
boldine
Homo sapiens
-
pH and temperature not specified in the publication
0.002
calcitonin gene-related peptide
Mus musculus
-
-
-
0.056
californidine
Homo sapiens
-
at pH 7.4 and 37°C
0.152
canadine
Homo sapiens
-
at pH 7.4 and 37°C
0.00000083
caproyl-L-Pro-((2S)-hydroxyacetyl)pyrrolidine
Homo sapiens
-
-
0.0028
cis-3,5,4'-trihydroxystilbene 4'-O-beta-D-(6-O-galloyl)glucopyranoside
Elizabethkingia meningoseptica
-
IC50: 0.0028 mM, noncompetitive inhibition
0.289
corynoline
Homo sapiens
-
at pH 7.4 and 37°C
0.128
corypalmine
Homo sapiens
-
at pH 7.4 and 37°C
0.0000003
cyclopent-2-ene-1,2-dicarboxylic acid 2-benzylamide 1-[2(S)-(hydroxyacetyl)-H-pyrrolidine]amide
Sus scrofa
at 25°C between pH 5.5 and 9.5
0.099
dihydrosanquinarine
Homo sapiens
-
at pH 7.4 and 37°C
1
galanthamine
Homo sapiens
-
IC50 above 1.0 mM, pH and temperature not specified in the publication
0.00939
gallic acid 4-O-beta-D-(6-O-galloyl)glucopyranoside
Elizabethkingia meningoseptica
-
IC50: 0.00939 mM, noncompetitive inhibition
0.00062
ginkgolic acid
Homo sapiens
-
-
0.000048
glutaric acid bis(L-prolyl-pyrrolidine) amide
Sus scrofa
-
IC50: 48 nM
1
isocorydine
Homo sapiens
-
IC50 above 1.0 mM, pH and temperature not specified in the publication
0.000054
isophthalic acid (L-proline methyl ester) L-prolyl-pyrrolidine amide
Sus scrofa
-
IC50: 54 nM
0.00064
isophthalic acid 2(S)-(cyclopentanecarbonyl)pyrrolidine (L-proline methyl ester) amide
Sus scrofa
-
IC50: 640 nM
0.00000061
isophthalic acid 2(S)-(cyclopentanecarbonyl)pyrrolidine L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine amide
Sus scrofa
-
IC50: 0.61 nM, log P: 0.2, the log P value is a first prediction of the blood-brain barrier penetrability
0.000014
isophthalic acid 2(S)-(cyclopentylcarbonyl)pyrrolidine L-prolyl-pyrrolidine amide
Sus scrofa
-
IC50: 14 nM, log P: 1.1, the log P value is a first prediction of the blood-brain barrier penetrability
0.00000072
isophthalic acid 2(S)-(cylcohexanecarbonyl)pyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide
Sus scrofa
-
IC50: 0.72 nM
0.0000011
isophthalic acid 2(S)-(cylcopentanecarbonyl)pyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide
Sus scrofa
-
IC50: 1.1 nM, log P: 0.8, the log P value is a first prediction of the blood-brain barrier penetrability
0.0000012
isophthalic acid 2(S)-acetylpyrrolidine L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine amide
Sus scrofa
-
IC50: 1.2 nM
0.0000042
isophthalic acid 2(S)-acetylpyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide
Sus scrofa
-
IC50: 4.2 nM, log P: -0.6, the log P value is a first prediction of the blood-brain barrier penetrability
0.000065
isophthalic acid 2(S)-acetylpyrrolidine L-prolyl-pyrrolidine amide
Sus scrofa
-
IC50: 65 nM
0.0000013
isophthalic acid 2(S)-benzoylpyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide
Sus scrofa
-
IC50: 1.3 nM, log P: 1.1, the log P value is a first prediction of the blood-brain barrier penetrability
0.000018
isophthalic acid 2(S)-benzoylpyrrolidine L-prolyl-pyrrolidine amide
Sus scrofa
-
IC50: 18 nM
0.0000016
isophthalic acid 2(S)-isobutanoylpyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide
Sus scrofa
-
IC50: 1.6 nM, log P: 0.3, the log P value is a first prediction of the blood-brain barrier penetrability
0.000026
isophthalic acid bis(L-prolyl-pyrrolidine) amide
0.000078
isophthalic acid bis-2(S)-(cyclopentanecarbonyl)pyrrolidine amide
Sus scrofa
-
IC50: 78 nM, log P: 2.7, the log P value is a first prediction of the blood-brain barrier penetrability
0.00000039
isophthalic acid L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine L-prolyl-pyrrolidine amide
Sus scrofa
-
IC50: 0.39 nM
0.0000015
isophthalic acid L-prolyl-2(S)-cyanopyrrolidine L-prolyl-pyrrolidine amide
Sus scrofa
-
IC50: 1.5 nM
0.0000013
isophthalic acid L-prolyl-pyrrolidine L-prolyl-L-prolinal amide
Sus scrofa
-
IC50: 1.3 nM
0.000031
isophthalic acid L-prolylbenzylamine L-prolyl-pyrrolidine amide
Sus scrofa
-
IC50: 31 nM
0.0000002 - 0.00000083
JTP-4819
0.00114
kinapsin-24
Homo sapiens
-
-
0.00000015
KYP-2047
Homo sapiens
-
wild type enzyme, at pH 8.0 and 25°C
0.5224
laurotetanine
Homo sapiens
-
pH and temperature not specified in the publication
0.0265
licuroside
Elizabethkingia meningoseptica
-
IC50: 0.0265 mM, noncompetitive inhibition
0.0000426
macranganin
Homo sapiens
-
-
0.003
methyl (1R,3S,4S,5S)-3-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.005
methyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
Homo sapiens
-
pH and temperature not specified in the publication
0.2
N-ethylmaleimide
Coprinopsis clastophylla
-
at pH 8.0 and 37°C
0.135 - 0.1354
N-methyllaurotetanine
0.0000042
N-[(2S)-1-[(2S)-2-formylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-4-phenylbutanamide
Bos taurus
-
brain
0.00000105
N-[(2S)-3-methyl-1-oxo-1-[(2S)-2-(piperidin-1-ylcarbonyl)pyrrolidin-1-yl]butan-2-yl]-3-phenoxybenzamide
Sus scrofa
kidney
0.3204
norisocorydine
Homo sapiens
-
pH and temperature not specified in the publication
0.5897
pallidine
Homo sapiens
-
pH and temperature not specified in the publication
0.021
phthalic acid bis(L-prolyl-pyrrolidine) amide
Sus scrofa
-
IC50: 0.021 mM
0.687
platycerine
Homo sapiens
-
at pH 7.4 and 37°C
0.392 - 0.3923
reticuline
0.022
rhodionin
Flavobacterium sp.
-
IC50: 0.022 mM
0.041
rhodiosin
Flavobacterium sp.
-
IC50: 0.041 mM
0.00084
rosiridin
Flavobacterium sp.
-
IC50: 840 nM
0.0524 - 0.0637
rosmarinic acid
0.0000267
rugosin E
Homo sapiens
-
-
0.1431
sinoacutine
Homo sapiens
-
pH and temperature not specified in the publication
0.00077
staurosporine
Homo sapiens
-
-
0.000083 - 0.000092
SUAM 14746
0.000002 - 0.0021
SUAM-1221
0.000077
succinic acid bis(L-prolyl-pyrrolidine) amide
Sus scrofa
-
IC50: 77 nM
0.000081
terephthalic acid bis(L-prolyl-pyrrolidine) amide
Sus scrofa
-
IC50: 81 nM
0.000029
tert-butyl (2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidine-1-carboxylate
Sus scrofa
brain
0.0878
Tyr-Pro-Ile-Pro-Phe
Elizabethkingia meningoseptica
-
-
0.017
Val-Glu-Ile-Pro-Glu
Elizabethkingia meningoseptica
-
-
0.0034
verbascoside
Homo sapiens
-
pH and temperature not specified in the publication
0.00049 - 0.0086
Y-29794 oxalate
0.0031 - 0.0061
Z-Ala-Pro-aldehyde
0.0000032 - 0.0000168
Z-Ala-Pro-chloromethylketone
0.0013 - 0.0024
Z-Arg-Pro-aldehyde
0.0000029 - 0.0000048
Z-Arg-Pro-chloromethylketone
0.0061 - 0.0076
Z-Gly-Pro-aldehyde
0.0000014
Z-L-prolyl-L-prolinal
Homo sapiens
-
-
0.003 - 0.0072
Z-Lys-Pro-aldehyde
0.000012 - 0.00016
Z-Pro-Pro-aldehyde
0.000733 - 0.005111
Z-Pro-Pro-aldehyde-dimethylacetal
0.0000004 - 0.0000516
Z-Pro-prolinal
2.75 - 2.8
Z-prolyl-prolinal
0.0044 - 0.011
Z-Tyr-Pro-aldehyde
0.0000023
[(1R,2R)-2-phenylcyclopropyl][(2S,3aS,7aS)-2-(1H-pyrrol-1-ylcarbonyl)octahydro-1H-indol-1-yl]methanone
Rattus norvegicus
-
rat cortex
0.0000012
[(1R,2R)-2-phenylcyclopropyl][(2S,3aS,7aS)-2-(pyrrolidin-1-ylcarbonyl)octahydro-1H-indol-1-yl]methanone
Rattus norvegicus
-
rat cortex
0.000005
[(1R,2R)-2-phenylcyclopropyl][(3S)-3-(pyrrolidin-1-ylcarbonyl)-2-azabicyclo[2.2.2]oct-2-yl]methanone
Rattus norvegicus
-
rat cortex
additional information
additional information
Elizabethkingia meningoseptica
-
-
-
0.000012
(6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
Homo sapiens
-
-
0.00004
(6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
Homo sapiens
-
-
0.00000029
(S)-1-((S)-1-(4-phenylbutanoyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
Rattus norvegicus
-
cell free assay, pH and temperature not specified in the publication
0.00001
(S)-1-((S)-1-(4-phenylbutanoyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
in situ assay, pH and temperature not specified in the publication
0.065
4-(4-chlorophenyl)-8-(ethoxycarbonyl)-5-methyl-2,3-dihydrofuro[3,2-c]quinolin-5-ium iodide
Homo sapiens
-
-
0.133
4-(4-chlorophenyl)-8-(ethoxycarbonyl)-5-methyl-2,3-dihydrofuro[3,2-c]quinolin-5-ium iodide
Homo sapiens
-
-
0.142
Berberine
Homo sapiens
-
at pH 7.4 and 37°C
0.1423
Berberine
Homo sapiens
-
pH and temperature not specified in the publication
0.145
Berberine
Homo sapiens
-
-
0.00204
Boc-Asn-Phe-Pro-aldehyde
Rattus norvegicus
-
cell free assay, pH and temperature not specified in the publication
0.00294
Boc-Asn-Phe-Pro-aldehyde
Homo sapiens
-
in situ assay, pH and temperature not specified in the publication
0.000026
isophthalic acid bis(L-prolyl-pyrrolidine) amide
Sus scrofa
-
IC50: 26 nM
0.000026
isophthalic acid bis(L-prolyl-pyrrolidine) amide
Sus scrofa
-
IC50: 26 nM, log O = -0.2, the log P value is a first prediction of the blood-brain barrier penetrability
0.0000002
JTP-4819
Sus scrofa
-
IC50: 0.2 nM
0.00000083
JTP-4819
Rattus norvegicus
-
rat brain
0.135
N-methyllaurotetanine
Homo sapiens
-
at pH 7.4 and 37°C
0.1354
N-methyllaurotetanine
Homo sapiens
-
pH and temperature not specified in the publication
0.392
reticuline
Homo sapiens
-
at pH 7.4 and 37°C
0.3923
reticuline
Homo sapiens
-
pH and temperature not specified in the publication
0.0524
rosmarinic acid
Setaria cervi
-
at pH 8.0 and 37°C
0.0637
rosmarinic acid
Mus musculus
-
-
0.000083
SUAM 14746
Homo sapiens
-
at pH 8.0 and 37°C
0.000092
SUAM 14746
Schistosoma mansoni
at pH 8.0 and 37°C
0.000002
SUAM-1221
Sus scrofa
-
IC50: 2 nM
0.0000022
SUAM-1221
Sus scrofa
-
IC50: 2.2 nM
0.0000022
SUAM-1221
Sus scrofa
brain
0.0000047
SUAM-1221
Mus musculus
-
brain
0.0000072
SUAM-1221
Rattus norvegicus
-
rat brain
0.000076
SUAM-1221
Canis lupus familiaris
-
brain
0.0021
SUAM-1221
Bos taurus
-
brain
0.0000016
UAMC-00021
Sus scrofa
-
-
0.0000016
UAMC-00021
Sus scrofa
-
0.00049
Y-29794 oxalate
Homo sapiens
-
at pH 8.0 and 37°C
0.0086
Y-29794 oxalate
Schistosoma mansoni
at pH 8.0 and 37°C
0.0031
Z-Ala-Pro-aldehyde
Schistosoma mansoni
at pH 8.0 and 37°C
0.0061
Z-Ala-Pro-aldehyde
Homo sapiens
-
at pH 8.0 and 37°C
0.0000032
Z-Ala-Pro-chloromethylketone
Schistosoma mansoni
at pH 8.0 and 37°C
0.0000168
Z-Ala-Pro-chloromethylketone
Homo sapiens
-
at pH 8.0 and 37°C
0.0013
Z-Arg-Pro-aldehyde
Schistosoma mansoni
at pH 8.0 and 37°C
0.0024
Z-Arg-Pro-aldehyde
Homo sapiens
-
at pH 8.0 and 37°C
0.0000029
Z-Arg-Pro-chloromethylketone
Schistosoma mansoni
at pH 8.0 and 37°C
0.0000048
Z-Arg-Pro-chloromethylketone
Homo sapiens
-
at pH 8.0 and 37°C
0.0061
Z-Gly-Pro-aldehyde
Schistosoma mansoni
at pH 8.0 and 37°C
0.0076
Z-Gly-Pro-aldehyde
Homo sapiens
-
at pH 8.0 and 37°C
0.003
Z-Lys-Pro-aldehyde
Schistosoma mansoni
at pH 8.0 and 37°C
0.0072
Z-Lys-Pro-aldehyde
Homo sapiens
-
at pH 8.0 and 37°C
0.000012
Z-Pro-Pro-aldehyde
Homo sapiens
-
at pH 8.0 and 37°C
0.00016
Z-Pro-Pro-aldehyde
Schistosoma mansoni
at pH 8.0 and 37°C
0.000733
Z-Pro-Pro-aldehyde-dimethylacetal
Rattus norvegicus
-
cell free assay, pH and temperature not specified in the publication
0.005111
Z-Pro-Pro-aldehyde-dimethylacetal
Homo sapiens
-
in situ assay, pH and temperature not specified in the publication
0.0000004
Z-Pro-prolinal
Sus scrofa
at 25°C between pH 5.5 and 9.5
0.00000287
Z-Pro-prolinal
Setaria cervi
-
at pH and °C
0.0000516
Z-Pro-prolinal
Homo sapiens
-
-
2.75
Z-prolyl-prolinal
Homo sapiens
-
at pH 7.4 and 37°C
2.8
Z-prolyl-prolinal
Homo sapiens
-
pH and temperature not specified in the publication
0.0044
Z-Tyr-Pro-aldehyde
Schistosoma mansoni
at pH 8.0 and 37°C
0.011
Z-Tyr-Pro-aldehyde
Homo sapiens
-
at pH 8.0 and 37°C
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.