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(35S) Met-labeled proteolytically inactive S306 form of full length HtrA2 + H2O
?
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?
(7-methoxycoumarin-4-yl)acetyl-IRRVSYSF(Dnp)KK + H2O
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best substrate
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?
(7-methoxycoumarin-4-yl)acetyl-VTLCAVPS(Dnp)KK + H2O
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cleavage occurs between cysteine and alanine
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?
(7-methoxycoumarin-4-yl)AIRRVSYSF-(5-amino-2-nitro)benzamide + H2O
?
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?
2-aminobenzoic acid-Ile-Met-Thr-Abu-Tyr-Met-His-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoic acid-Ile-Met-Thr + Abu-Tyr-Met-His-Tyr(3-NO2)-NH2
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?
2-aminobenzoic acid-Ile-Met-Thr-Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoic acid-Ile-Met-Thr + Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2
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?
2-aminobenzoic acid-Ile-Met-Thr-Abu-Tyr-Met-Trp-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoic acid-Ile-Met-Thr + Abu-Tyr-Met-Trp-Tyr(3-NO2)-NH2
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?
2-aminobenzoic acid-Ile-Met-Thr-Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoic acid-Ile-Met-Thr + Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2
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?
2-aminobenzoic acid-Ile-Met-Val-Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoic acid-Ile-Met-Val + Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2
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?
2-aminobenzoic acid-Ile-Met-Val-Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoic acid-Ile-Met-Val + Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2
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?
2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-His-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoyl-Ile-Met-Thr + Abu-Tyr-Met-His-Tyr(3-NO2)-NH2
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-
?
2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoyl-Ile-Met-Thr + Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2
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-
?
2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-Trp-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoyl-Ile-Met-Thr + Abu-Tyr-Met-Trp-Tyr(3-NO2)-NH2
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-
?
2-aminobenzoyl-Ile-Met-Val-Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoyl-Ile-Met-Val + Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2
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?
2-aminobenzoyl-Ile-Met-Val-Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoyl-Ile-Met-Val + Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2
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?
35S-beta-casein + H2O
?
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C-terminus of presenilin-1 interacts the PDZ domain of with Omi/HtrA2, increasing its activity
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?
A beta 40
?
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HtrA2/Omi binds preferentially to the short form of A beta peptides, the enzyme does not perform degradation by direct hydrolysis
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?
A beta 42
?
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HtrA2/Omi binds poorly to A beta 42, the enzyme does not perform degradation by direct hydrolysis
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?
Ala(7-methoxycoumarin-4-acetic acid)-IRRVSYSF-(5-amido-2-nitrobenzamide) + H2O
?
alpha-secretase peptide
?
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HtrA2/Omi does not perform degradation by direct hydrolysis
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?
amyloid precursor protein + H2O
?
amyloid precursor protein-like protein 1 + H2O
?
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processed into two major fragments of 65 and 67 kDa
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?
amyloid precursor protein-like protein 2 + H2O
?
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processed into cleaved fragments of 103 and 109 kDa
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?
beta-casein
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protease activity is activated by the binding of the PDZ domain of the mature form of Omi to the C-terminal region of the reduced form of Pag
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?
beta-secretase peptide
?
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HtrA2/Omi does not perform degradation by direct hydrolysis
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?
c-inhibitor of apoptosis protein1 + H2O
?
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C-terminus of presenilin-1 interacts with the PDZ domain of Omi/HtrA2, increasing its activity
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?
c-inhibitor of apoptosis protein2 + H2O
?
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C-terminus of presenilin-1 interacts with the PDZ domain of Omi/HtrA2, increasing its activity
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?
dephosphorylated casein + H2O
?
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?
Fas-Fas L + H2O
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FLIP + H2O
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Fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein
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?
gamma-secretase peptide
?
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HtrA2/Omi binds less strongly to gamma-secretase substrate peptide as compared to alpha-secretase substrate peptide and beta-secretase substrate peptide, the enzyme does not perform degradation by direct hydrolysis
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?
glycoprotein alpha1 + H2O
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?
glycprotein alpha1 acid + H2O
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HS1-associated protein X-1 + H2O
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HtrA2/Omi-mediated degradation of HS1-associated protein X-1 correlates with extensive cell death in response to etoposide, cisplatin and H2O2
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?
HS1-associated protein X1 + H2O
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HAX-1
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inhibitor of apoptosis + H2O
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Livin alpha + H2O
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?
PDZ-interacting peptides + H2O
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PED-PEA 15 + H2O
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death effector domain-containing protein
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ped/pea-15
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HtrA2 is a specific interactor of the ped/pea-15 death effector domain and leads to its degradation
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?
protein cIAP1 + H2O
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best substrate, preferred cleavage sites are after Thr4, Asn133 and Leu161
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?
protein cIAP2 + H2O
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protein DIAP1 + H2O
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protein XIAP + H2O
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receptor-interacting protein 1 + H2O
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the HtrA2/Omi cleavage site receptor-interacting protein 1 is mapped to the intermediate domain and the corresponding N- and C-terminal fragments are impaired in their ability to activate nuclear factor-kappaB, c-Jun N-terminal kinase and p38 mitogen-activated protein kinase
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?
reduced bovine serum albumin
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HtrA2-Opt peptides stimulate the delta N-HtrA1 protease activity more than 3fold
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?
SPMFKGV-p-nitroanilide + H2O
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?
thanatos-associated protein 5 (THAP5) + H2O
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in a yeast two-hybrid assay it is shown that Omi/HtrA2 protease interacts with thanatos-associated protein 5. Degradation assays show that thanatos-associated protein 5 is cleaved by Omi/HtrA2
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?
ubiquitin carboxyl-terminal hydrolase L1 + H2O
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natural substrate for HtrA2 in the apoptotic pathway. HtrA2 directly cleaves UCH-L1 and inhibits its hydrolase activity
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?
unidentified substrate + H2O
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its cleavage by Omi/HtrA2 leads to permeabilization of the mitochondria outer membrane and release of chytochrome c followed by enhanced caspase activation
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?
WARTS kinase + H2O
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WARTS, WTS, large tumor-suppressor 1 mitotic kinase
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?
Wilms' tumor suppressor 1 + H2O
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Wilms' tumor suppressor protein WT1 + H2O
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X-linked inhibitor of apoptosis protein
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HtrA2 promotes degradation of the X-linked inhibitor of apoptosis protein followed by subsequent caspase activation
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?
X-linked inhibitor of apoptosis protein + H2O
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additional information
?
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Ala(7-methoxycoumarin-4-acetic acid)-IRRVSYSF-(5-amido-2-nitrobenzamide) + H2O
?
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?
Ala(7-methoxycoumarin-4-acetic acid)-IRRVSYSF-(5-amido-2-nitrobenzamide) + H2O
?
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?
alpha-casein + H2O
?
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?
alpha-casein + H2O
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?
alpha-casein + H2O
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?
alpha-casein + H2O
?
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?
alpha-casein + H2O
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?
amyloid precursor protein + H2O
?
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?
amyloid precursor protein + H2O
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APP
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?
amyloid precursor protein + H2O
?
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efficient cleavage by HtrA2 in the normal physiological condition. HtrA2-mediated cleavage product is the C161 fragment encompassing amino acids 535695 of amyloid precursor protein 695. Mature HtrA2 and full-length HtrA2 can process amyloid precursor protein into C161
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?
amyloid precursor protein + H2O
?
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?
Apollon + H2O
?
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HtrA2 cleaves Apollon, a huge inhibitor of apoptosis protein, with its serine protease activity, conversely, Apollon ubiquitylates and facilitates proteasomal degradation of HtrA2, thus both downregulate each other
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?
Apollon + H2O
?
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BRUCE-apollon
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?
beta-casein + H2O
?
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?
beta-casein + H2O
?
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?
beta-casein + H2O
?
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?
beta-casein + H2O
?
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?
beta-casein + H2O
?
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?
beta-casein + H2O
?
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?
beta-casein + H2O
?
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?
beta-casein + H2O
?
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?
beta-casein + H2O
?
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?
beta-casein + H2O
?
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?
beta-casein + H2O
?
preferred substrate
-
?
beta-casein + H2O
?
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main selectivity at position P1 is for non-polar aliphatic amino acids, in particular valine, isoleucine and methionine. At the P2 and P3 positions arginine is selected most strongly with a secondary selection for other hydrophilic residues
-
?
beta-casein + H2O
?
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?
beta-casein + H2O
?
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?
beta-casein + H2O
?
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?
beta-casein + H2O
?
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?
beta-casein + H2O
?
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?
beta-casein + H2O
?
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?
beta-casein + H2O
?
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?
beta-casein + H2O
?
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?
beta-casein + H2O
?
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cleaved to approximately 50% by GST-HtrA2 after a cleavage reaction for 1 h
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-
?
Bir1p
?
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?
Bir1p + H2O
?
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inhibitor of apoptosis proteins (IAP) Bir1p is a substrate for Nma11p, which is the yeast homologue of the human OMI/HtrA2, Bir1p physically interacts with the N-terminal HtrA-like repeat of Nma11p
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?
Bir1p + H2O
?
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inhibitor of apoptosis proteins (IAP) Bir1p is a substrate for Nma11p, which is the yeast homologue of the human OMI/HtrA2, Bir1p physically interacts with the N-terminal HtrA-like repeat of Nma11p
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?
casein + H2O
?
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?
casein + H2O
?
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strong hydrolytic activity
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?
hyaluronidase + H2O
?
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?
hyaluronidase + H2O
?
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?
inhibitor of apoptosis + H2O
?
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IAP
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?
inhibitor of apoptosis + H2O
?
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enzyme cleaves various IAPs
-
?
parkin + H2O
?
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using cleavage and binding assays, it is demonstrated that HtrA2 specifically binds to and directly cleaves the E3 ubiquitin ligase Parkin
-
-
?
parkin + H2O
?
-
HtrA2/Omi cleaves E3 ubiquitin ligase Parkin
-
-
?
Wilms' tumor suppressor 1 + H2O
?
-
bona fide substrate for HtrA2-mediated proteolysis, cleavage sites are in the C terminus at Val286 and Leu320, resulting in fragments of 20000 and 35000 Da, respectively, while another cleavage site is in the N terminus at Leu91 adjacent to suppression domain
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-
?
Wilms' tumor suppressor 1 + H2O
?
-
HtrA2 cleaves at, at least, two specific sites. Wilms' tumor suppressor 1 degradation by HtrA2 reveals two major proteolytic products of 20000 Da and 15000 Da, but the same samples immunoblotted with N-Ter antibody reveals major fragment sizes of 35000 Da and 30000 Da. The potential cleavage site that produces the 20000 Da fragment is at Val286, and the potential cleavage site producing the 15000 Da fragment is at Leu320
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-
?
Wilms' tumor suppressor protein WT1 + H2O
?
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-
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-
?
Wilms' tumor suppressor protein WT1 + H2O
?
-
using a yeat two-hybrid assay WT1 is identified as a binding partner of HtrA2/Omi. HtrA2/Omi cleaves WT1 at multiple binding sites following the treatment of cells with cytotoxic drugs
-
-
?
Wilms' tumor suppressor protein WT1 + H2O
?
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?
WTS + H2O
?
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-
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-
?
WTS + H2O
?
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is a non-apoptotic substrate of Omi
-
-
?
X-linked inhibitor of apoptosis protein + H2O
?
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-
?
X-linked inhibitor of apoptosis protein + H2O
?
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autocatalytically processing of HtrA2 to the 36-kDa protein fragment, which is required for the cytochrome c-dependent caspase activation, promoting apoptotic cell death
-
-
?
X-linked inhibitor of apoptosis protein + H2O
?
-
BIR2
-
-
?
X-linked inhibitor of apoptosis protein + H2O
?
-
C-terminus of presenilin-1 interacts with the PDZ domain of Omi/HtrA2, increasing its activity
-
-
?
X-linked inhibitor of apoptosis protein + H2O
?
-
homotrimeric structure of enzyme is required for executing its activity
-
-
?
X-linked inhibitor of apoptosis protein + H2O
?
-
Omi/HtrA2 cleaves as well as directly binds and inactivates X-linked inhibitor of apoptosis protein to promote caspase activation
-
-
?
X-linked inhibitor of apoptosis protein + H2O
?
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-
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-
?
X-linked inhibitor of apoptosis protein + H2O
?
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?
X-linked inhibitor of apoptosis protein + H2O
?
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-
-
-
?
additional information
?
-
-
no cleavage of STDGGV-para-nitroaniline and SKAKGGEEPLPEGV-para-nitroaniline
-
-
?
additional information
?
-
cleavage of DIAP1 between the BIR1 and BIR2 domain and further degradation of BIR1
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-
?
additional information
?
-
-
Omi can degrade inhibitor of apoptosis proteins
-
?
additional information
?
-
-
can promote caspase activation and cell death apoptosis
-
?
additional information
?
-
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induces atypical cell death. Inhibits the caspase-inhibitory activity of XIAP by direct binding to it. Only mature form but not its precursor binds to IAPs
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?
additional information
?
-
role in apoptosis
-
?
additional information
?
-
role in apoptosis
-
?
additional information
?
-
-
role in apoptosis, amino-terminal IAP interaction motif displaces IAPs from caspases, leading to enhanced caspase activity
-
?
additional information
?
-
-
role in apoptosis, binds to XIAP-binding protein
-
?
additional information
?
-
role in apoptosis, degradation of aberrantly folded proteins during conditions of cellular stress
-
?
additional information
?
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-
role in apoptosis, degradation of aberrantly folded proteins during conditions of cellular stress
-
?
additional information
?
-
-
role in apoptosis, enzyme can induce apoptosis in a caspase-independent manner through its protease activity and in a caspase-dependent manner via its ability to disrupt caspase-IAP interaction
-
?
additional information
?
-
-
does not bind the reversed control peptide A beta 41-1 and peptide H2-Opt
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-
?
additional information
?
-
-
beta-synuclein is not cleaved by HtrA2
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-
?
additional information
?
-
-
degradation of inhibitor of apoptosis proteins, IAPs
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-
?
additional information
?
-
-
HtrA2 cleaves p73alpha in the C-terminal portion
-
-
?
additional information
?
-
-
co-immunoprecipitation show direct interaction of Omi/HtrA2 with optic atrophy protein 1 (OPA1)
-
-
?
additional information
?
-
-
HtrA2 fails to cleave the Wilms' tumor suppressor 1 cofactors Par-4 and BASP1
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-
?
additional information
?
-
allostery does regulate HtrA2 activity using a non-canonical selective binding pocket in HtrA2 which initiates signal propagation to the distal active site through a complex allosteric mechanism
-
-
?
additional information
?
-
-
induces cell death in a caspase-dependent manner
-
?
additional information
?
-
-
promotes apoptosis
-
?
additional information
?
-
-
role in apoptosis
-
?
additional information
?
-
-
role in apoptosis, mice with mutant HtrA2/Omi suffer from neurodegenerative disease due to progressive mitochondrial damage, mutant enzyme is proteolytically inactive but can bind to IAPs
-
?
additional information
?
-
loss of enzyme activity causes neuromuscular disorder
-
?
additional information
?
-
-
loss of enzyme activity causes neuromuscular disorder
-
?
additional information
?
-
role in apoptosis
-
?
additional information
?
-
-
role in apoptosis, mice with mutant HtrA2/Omi suffer from neurodegenerative disease due to progressive mitochondrial damage, mutant enzyme is proteolytically inactive but can bind to IAPs
-
?
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Vaux, D.L.; Silke, J.
Mammalian mitochondrial IAP binding proteins
Biochem. Biophys. Res. Commun.
304
499-504
2003
Mus musculus
brenda
Gray, C.W.; Ward, R.V.; Karran, E.; Turconi, S.; Rowles, A.; Viglienghi, D.; Southan, C.; Barton, A.; Fantom, K.G.; West, A.; Savopoulos, J.; Hassan, N.J.; Clinkenbeard, H.; Hanning, C.; Amegadzie, B.; Davis, J.B.; Dingwall, C.; Livi, G.P.; Creasy, C.L.
Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response
Eur. J. Biochem.
267
5699-5710
2000
Homo sapiens (O43464), Mus musculus (Q9JIY5)
brenda
Yang, Q.H.; Church-Hajduk, R.; Ren, J.; Newton, M.L.; Du, C.
Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis
Genes Dev.
17
1487-1496
2003
Mammalia
brenda
Faccio, L.; Fusco, C.; Chen, A.; Martinotti, S.; Bonventre, J.V.; Zervos, A.S.
Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia
J. Biol. Chem.
275
2581-2588
2000
Homo sapiens (O43464)
brenda
Hegde, R.; Srinivasula, S.M.; Zhang, Z.; Wassell, R.; Mukattash, R.; Cilenti, L.; DuBois, G.; Lazebnik, Y.; Zervos, A.S.; Fernandes-Alnemri, T.; Alnemri, E.S.
Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction
J. Biol. Chem.
277
432-438
2002
Homo sapiens
brenda
Martins, L.M.; Iaccarino, I.; Tenev, T.; Gschmeissner, S.; Totty, N.F.; Lemoine, N.R.; Savopoulos, J.; Gray, C.W.; Creasy, C.L.; Dingwall, C.; Downward, J.
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif
J. Biol. Chem.
277
439-444
2002
Homo sapiens
brenda
Verhagen, A.M.; Silke, J.; Ekert, P.G.; Pakusch, M.; Kaufmann, H.; Connolly, L.M.; Day, C.L.; Tikoo, A.; Burke, R.; Wrobel, C.; Moritz, R.L.; Simpson, R.J.; Vaux, D.L.
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
J. Biol. Chem.
277
445-454
2002
Mammalia
brenda
Cilenti, L.; Lee, Y.; Hess, S.; Srinivasula, S.; Park, K.M.; Junqueira, D.; Davis, H.; Bonventre, J.V.; Alnemri, E.S.; Zervos, A.S.
Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2
J. Biol. Chem.
278
11489-11494
2003
Mammalia
brenda
Srinivasula, S.M.; Gupta, S.; Datta, P.; Zhang, Z.; Hegde, R.; Cheong, N.; Fernandes-Alnemri, T.; Alnemri, E.S.
Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2
J. Biol. Chem.
278
31469-31472
2003
Homo sapiens
brenda
Martins, L.M.; Turk, B.E.; Cowling, V.; Borg, A.; Jarrell, E.T.; Cantley, L.C.; Downward, J.
Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi
J. Biol. Chem.
278
49417-49427
2003
Homo sapiens
brenda
Suzuki, Y.; Imai, Y.; Nakayama, H.; Takahashi, K.; Takio, K.; Takahashi, R.
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
Mol. Cell
8
613-621
2001
Homo sapiens
brenda
Li, W.; Srinivasula, S.M.; Chai, J.; Li, P.; Wu, J.W.; Zhang, Z.; Alnemri, E.S.; Shi, Y.
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi
Nat. Struct. Biol.
9
436-441
2002
Mammalia
brenda
Jones, J.M.; Datta, P.; Srinivasula, S.M.; Ji, W.; Gupta, S.; Zhang, Z.; Davies, E.; Hajnoczky, G.; Saunders, T.L.; Van Keuren, M.L.; Fernandes-Alnemri, T.; Meisler, M.H.; Alnemri, E.S.
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice
Nature
425
721-727
2003
Mus musculus (Q9JIY5), Mus musculus
brenda
Savopoulos, J.W.; Carter, P.S.; Turconi, S.; Pettman, G.R.; Karran, E.H.; Gray, C.W.; Ward, R.V.; Jenkins, O.; Creasy, C.L.
Expression, purification, and functional analysis of the human serine protease HtrA2
Protein Expr. Purif.
19
227-234
2000
Homo sapiens (O43464), Homo sapiens
brenda
Cilenti, L.; Kyrizis, G.A.; Soundarapandian, M.M.; Stratico, V.; Yerkes, A.; Park, K.M.; Sheridan, A.M.; Alnemri, E.S.; Bonventre, J.V.; Zervos, A.S.
Omi/HtrA2 protease mediates cisplatin-induced cell death in renal cells
Am. J. Physiol. Renal Physiol.
288
F371-F379
2005
Homo sapiens, Mus musculus, Mus musculus C57BL6
brenda
Sekine, K.; Hao, Y.; Suzuki, Y.; Takahashi, R.; Tsuruo, T.; Naito, M.
HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells
Biochem. Biophys. Res. Commun.
330
279-285
2005
Homo sapiens
brenda
Murwantoko, C.; Yano, M.; Ueta, Y.; Murasaki, A.; Kanda, H.; Oka, C.; Kawaichi, M.
Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease
Biochem. J.
381
895-904
2004
Homo sapiens
brenda
Zhang, X.; Chang, Z
Temperature dependent protease activity and structural properties of human HtrA2 protease
Biochemistry (Moscow)
69
687-692
2004
Homo sapiens
brenda
Suzuki, Y.; Takahashi-Niki, K.; Akagi, T.; Hashikawa, T.; Takahashi, R.
Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways
Cell Death Differ.
11
208-216
2004
Homo sapiens
brenda
Blink, E.; Maianski, N.A.; Alnemri, E.S.; Zervos, A.S.; Roos, D.; Kuijpers, T.W.
Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils
Cell Death Differ.
11
937-939
2004
Homo sapiens
brenda
Liu, H.R.; Gao, E.; Hu, A.; Tao, L.; Qu, Y.; Most, P.; Koch, W.J.; Christopher, T.A.; Lopez, B.L.; Alnemri, E.S.; Zervos, A.S.; Ma, X.L.
Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion
Circulation
111
90-96
2005
Mus musculus, Rattus norvegicus
brenda
Nam, M.K.; Seong, Y.M.; Park, H.J.; Choi, J.Y.; Kang, S.; Rhim, H.
The homotrimeric structure of HtrA2 is indispensable for executing its serine protease activity
Exp. Mol. Med.
38
26-43
2006
Homo sapiens
brenda
Hong, S.K.; Cha, M.K.; Kim, I.H.
Specific protein interaction of human Pag with Omi/HtrA2 and the activation of the protease activity of Omi/HtrA2
Free Radic. Biol. Med.
40
275-284
2006
Homo sapiens
brenda
Strauss, K.M.; Martins, L.M.; Plun-Favreau, H.; Marx, F.P.; Kautzmann, S.; Berg, D.; Gasser, T.; Wszolek, Z.; Mueller, T.; Bornemann, A.; Wolburg, H.; Downward, J.; Riess, O.; Schulz, J.B.; Krueger, R.
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
Hum. Mol. Genet.
14
2099-2111
2005
Homo sapiens
brenda
Seong, Y.M.; Choi, J.Y.; Park, H.J.; Kim, K.J.; Ahn, S.G.; Seong, G.H.; Kim, I.K.; Kang, S.; Rhim, H.
Autocatalytic processing of HtrA2/Omi is essential for induction of caspase-dependent cell death through antagonizing XIAP
J. Biol. Chem.
279
37588-37596
2004
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Gupta, S.; Singh, R.; Datta, P.; Zhang, Z.; Orr, C.; Lu, Z.; Dubois, G.; Zervos, A.S.; Meisler, M.H.; Srinivasula, S.M.; Fernandes-Alnemri, T.; Alnemri, E.S.
The C-terminal tail of presenelin regulates Omi/HtrA2 protease activity
J. Biol. Chem.
279
45844-45854
2004
Homo sapiens
brenda
Trencia, A.; Fiory, F.; Maitan, M.A.; Vito, P.; Barbagallo, A.P.; Perfetti, A.; Miele, C.; Ungaro, P.; Oriente, F.; Cilenti, L.; Zervos, A.S.; Formisano, P.; Beguinot, F.
Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15
J. Biol. Chem.
279
46566-46572
2004
Homo sapiens
brenda
Walter, D.; Wissing, S.; Madeo, F.; Fahrenkrog, B.
The inhibitor-of-apoptosis protein Bir1p protects against apoptosis in S. cerevisiae and is a substrate for the yeast homologue of Omi/HtrA2
J. Cell Sci.
119
1843-1851
2006
Saccharomyces cerevisiae, Saccharomyces cerevisiae BYa
brenda
Liu, M.L.; Liu, M.J.; Kim, J.M.; Kim, H.J.; Kim, J.H.; Hong, S.T.
HtrA2 interacts with A beta peptide but does not directly alter its production or degradation
Mol. Cell
20
83-89
2005
Homo sapiens
brenda
Martins, L.M.; Morrison, A.; Klupsch, K.; Fedele, V.; Moisoi, N.; Teismann, P.; Abuin, A.; Grau, E.; Geppert, M.; Livi, G.P.; Creasy, C.L.; Martin, A.; Hargreaves, I.; Heales, S.J.; Okada, H.; Brandner, S.; Schulz, J.B.; Mak, T.; Downward, J.
Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice
Mol. Cell. Biol.
24
9848-9862
2004
Mus musculus
brenda
Park, H.J.; Seong, Y.M.; Choi, J.Y.; Kang, S.; Rhim, H.
Alzheimer's disease-associated amyloid beta interacts with the human serine protease HtrA2/Omi
Neurosci. Lett.
357
63-67
2004
Homo sapiens (Q92743), Homo sapiens
brenda
Seong, Y.M.; Park, H.J.; Seong, G.H.; Choi, J.Y.; Yoon, S.J.; Min, B.R.; Kang, S.; Rhim, H.
N-terminal truncation circumvents proteolytic degradation of the human HtrA2/Omi serine protease in Escherichia coli: rapid purification of a proteolytically active HtrA2/Omi
Protein Expr. Purif.
33
200-208
2004
Mus musculus, Homo sapiens (O43464), Homo sapiens
brenda
Meltzer, M.; Hasenbein, S.; Hauske, P.; Kucz, N.; Merdanovic, M.; Grau, S.; Beil, A.; Jones, D.; Krojer, T.; Clausen, T.; Ehrmann, M.; Kaiser, M.
Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control
Angew. Chem. Int. Ed. Engl.
47
1332-1334
2008
Bacteria
brenda
Kim, G.Y.; Nam, M.K.; Kim, S.S.; Kim, H.Y.; Lee, S.K.; Rhim, H.
A simple and rapid strategy for the molecular cloning and monitoring of mouse HtrA2 serine protease
Biotechnol. Lett.
30
397-403
2008
Mus musculus
brenda
Vande Walle, L.; Lamkanfi, M.; Vandenabeele, P.
The mitochondrial serine protease HtrA2/Omi: an overview
Cell Death Differ.
15
453-460
2008
Bacillus sp. (in: Bacteria), Bos taurus, Canis lupus familiaris, Clostridium sp., Drosophila melanogaster, Escherichia coli, Homo sapiens, Macaca mulatta, Mesorhizobium loti, Mus musculus, no activity in Caenorhabditis elegans, no activity in Mycoplasma genitalium, no activity in Mycoplasma pneumoniae, Rattus norvegicus
brenda
Park, H.J.; Kim, S.S.; Seong, Y.M.; Kim, K.H.; Goo, H.G.; Yoon, E.J.; Min, d.o..S.; Kang, S.; Rhim, H.
Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications for the physiological function of HtrA2 in the mitochondria
J. Biol. Chem.
281
34277-34287
2006
Homo sapiens, Mus musculus
brenda
Yang, L.; Sun, M.; Sun, X.M.; Cheng, G.Z.; Nicosia, S.V.; Cheng, J.Q.
Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212
J. Biol. Chem.
282
10981-10987
2007
Homo sapiens
brenda
Plun-Favreau, H.; Klupsch, K.; Moisoi, N.; Gandhi, S.; Kjaer, S.; Frith, D.; Harvey, K.; Deas, E.; Harvey, R.J.; McDonald, N.; Wood, N.W.; Martins, L.M.; Downward, J.
The mitochondrial protease HtrA2 is regulated by Parkinsons disease-associated kinase PINK1
Nat. Cell Biol.
9
1243-1252
2007
Homo sapiens, Mus musculus
brenda
Althaus, J.; Siegelin, M.D.; Dehghani, F.; Cilenti, L.; Zervos, A.S.; Rami, A.
The serine protease Omi/HtrA2 is involved in XIAP cleavage and in neuronal cell death following focal cerebral ischemia/reperfusion
Neurochem. Int.
50
172-180
2007
Rattus norvegicus
brenda
Kuninaka, S.; Iida, S.I.; Hara, T.; Nomura, M.; Naoe, H.; Morisaki, T.; Nitta, M.; Arima, Y.; Mimori, T.; Yonehara, S.; Saya, H.
Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation
Oncogene
26
2395-2406
2007
Homo sapiens, Mus musculus, synthetic construct
brenda
Ma, X.; Kalakonda, S.; Srinivasula, S.M.; Reddy, S.P.; Platanias, L.C.; Kalvakolanu, D.V.
GRIM-19 associates with the serine protease HtrA2 for promoting cell death
Oncogene
26
4842-4849
2007
Homo sapiens
brenda
Zurawa-Janicka, D.; Kobiela, J.; Stefaniak, T.; Wozniak, A.; Narkiewicz, J.; Wozniak, M.; Limon, J.; Lipinska, B.
Changes in expression of serine proteases HtrA1 and HtrA2 during estrogen-induced oxidative stress and nephrocarcinogenesis in male Syrian hamster
Acta Biochim. Pol.
55
9-19
2008
Mesocricetus auratus (A9XDF4)
brenda
Plun-Favreau, H.; Gandhi, S.; Wood-Kaczmar, A.; Deas, E.; Yao, Z.; Wood, N.W.
What have PINK1 and HtrA2 genes told us about the role of mitochondria in Parkinsons disease?
Ann. N. Y. Acad. Sci.
1147
30-36
2008
Homo sapiens
brenda
Bhuiyan, M.S.; Fukunaga, K.
Activation of HtrA2, a mitochondrial serine protease mediates apoptosis: current knowledge on HtrA2 mediated myocardial ischemia/reperfusion injury
Cardiovasc. ther.
26
224-232
2008
Homo sapiens
brenda
Khan, F.S.; Fujioka, M.; Datta, P.; Fernandes-Alnemri, T.; Jaynes, J.B.; Alnemri, E.S.
The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila
Cell Death Differ.
15
1073-1083
2008
Drosophila melanogaster (Q9VFJ3)
brenda
Marabese, M.; Mazzoletti, M.; Vikhanskaya, F.; Broggini, M.
HtrA2 enhances the apoptotic functions of p73 on bax
Cell Death Differ.
15
849-858
2008
Homo sapiens
brenda
Tain, L.S.; Chowdhury, R.B.; Tao, R.N.; Plun-Favreau, H.; Moisoi, N.; Martins, L.M.; Downward, J.; Whitworth, A.J.; Tapon, N.
Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin
Cell Death Differ.
16
1118-1125
2009
Drosophila melanogaster (Q9VFJ3)
brenda
Moisoi, N.; Klupsch, K.; Fedele, V.; East, P.; Sharma, S.; Renton, A.; Plun-Favreau, H.; Edwards, R.E.; Teismann, P.; Esposti, M.D.; Morrison, A.D.; Wood, N.W.; Downward, J.; Martins, L.M.
Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response
Cell Death Differ.
16
449-464
2009
Mus musculus (Q8BHC7)
brenda
Narkiewicz, J.; Klasa-Mazurkiewicz, D.; Zurawa-Janicka, D.; Skorko-Glonek, J.; Emerich, J.; Lipinska, B.
Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer
Clin. Biochem.
41
561-569
2008
Homo sapiens
brenda
Bhuiyan, M.S.; Fukunaga, K.
Mitochondrial serine protease HtrA2/Omi as a potential therapeutic target
Curr. Drug Targets
10
372-383
2009
Homo sapiens
brenda
Inagaki, R.; Tagawa, K.; Qi, M.L.; Enokido, Y.; Ito, H.; Tamura, T.; Shimizu, S.; Oyanagi, K.; Arai, N.; Kanazawa, I.; Wanker, E.E.; Okazawa, H.
Omi /HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntingtons disease
Eur. J. Neurosci.
28
30-40
2008
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Simon-Sanchez, J.; Singleton, A.B.
Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls
Hum. Mol. Genet.
17
1988-1993
2008
Homo sapiens (O43464)
brenda
Bogaerts, V.; Nuytemans, K.; Reumers, J.; Pals, P.; Engelborghs, S.; Pickut, B.; Corsmit, E.; Peeters, K.; Schymkowitz, J.; De Deyn, P.P.; Cras, P.; Rousseau, F.; Theuns, J.; Van Broeckhoven, C.
Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease
Hum. Mutat.
29
832-840
2008
Homo sapiens (O43464), Homo sapiens
brenda
Han, C.; Nam, M.K.; Park, H.J.; Seong, Y.M.; Kang, S.; Rhim, H.
Tunicamycin-induced ER stress upregulates the expression of mitochondrial HtrA2 and promotes apoptosis through the cytosolic release of HtrA2
J. Microbiol. Biotechnol.
18
1197-1202
2008
Homo sapiens
brenda
Yun, J.; Cao, J.H.; Dodson, M.W.; Clark, I.E.; Kapahi, P.; Chowdhury, R.B.; Guo, M.
Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo
J. Neurosci.
28
14500-14510
2008
Drosophila melanogaster (Q9VFJ3)
brenda
Chao, J.R.; Parganas, E.; Boyd, K.; Hong, C.Y.; Opferman, J.T.; Ihle, J.N.
Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons
Nature
452
98-102
2008
Mus musculus
brenda
Ross, O.A.; Soto, A.I.; Vilarino-Gueell, C.; Heckman, M.G.; Diehl, N.N.; Hulihan, M.M.; Aasly, J.O.; Sando, S.; Gibson, J.M.; Lynch, T.; Krygowska-Wajs, A.; Opala, G.; Barcikowska, M.; Czyzewski, K.; Uitti, R.J.; Wszolek, Z.K.; Farrer, M.J.
Genetic variation of Omi/HtrA2 and Parkinsons disease
Parkinsonism Relat. Disord.
14
539-543
2008
Homo sapiens
brenda
McCormick, A.L.; Roback, L.; Mocarski, E.S.
HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA)
PLoS Pathog.
4
e1000063
2008
Homo sapiens (O43464)
brenda
Krick, S.; Shi, S.; Ju, W.; Faul, C.; Tsai, S.Y.; Mundel, P.; Boettinger, E.P.
Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease
Proc. Natl. Acad. Sci. USA
105
14106-14111
2008
Chlorocebus aethiops, Homo sapiens, Mus musculus
brenda
Balakrishnan, M.P.; Cilenti, L.; Mashak, Z.; Popat, P.; Alnemri, E.S.; Zervos, A.S.
THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death
Am. J. Physiol. Heart Circ. Physiol.
297
H643-H653
2009
Homo sapiens
brenda
Su, D.; Su, Z.; Wang, J.; Yang, S.; Ma, J.
UCF-101, a novel Omi/HtrA2 inhibitor, protects against cerebral ischemia/reperfusion injury in rats
Anat. Rec. (Hoboken)
292
854-861
2009
Rattus norvegicus
brenda
Park, H.M.; Kim, G.Y.; Nam, M.K.; Seong, G.H.; Han, C.; Chung, K.C.; Kang, S.; Rhim, H.
The serine protease HtrA2/Omi cleaves Parkin and irreversibly inactivates its E3 ubiquitin ligase activity
Biochem. Biophys. Res. Commun.
387
537-542
2009
Homo sapiens, Mus musculus
brenda
Kieper, N.; Holmstroem, K.M.; Ciceri, D.; Fiesel, F.C.; Wolburg, H.; Ziviani, E.; Whitworth, A.J.; Martins, L.M.; Kahle, P.J.; Krueger, R.
Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1
Exp. Cell Res.
316
1213-1224
2010
Drosophila melanogaster, Homo sapiens, Mus musculus
brenda
Ding, X.; Patel, M.; Shen, D.; Herzlich, A.A.; Cao, X.; Villasmil, R.; Klupsch, K.; Tuo, J.; Downward, J.; Chan, C.C.
Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration
Invest. Ophthalmol. Vis. Sci.
50
4957-4966
2009
Mus musculus
brenda
Kooistra, J.; Milojevic, J.; Melacini, G.; Ortega, J.
A new function of human HtrA2 as an amyloid-beta oligomerization inhibitor
J. Alzheimers Dis.
17
281-294
2009
Homo sapiens
brenda
Wang, C.Y.; Lin, Y.S.; Su, W.C.; Chen, C.L.; Lin, C.F.
Glycogen synthase kinase-3 and Omi/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis
Mol. Biol. Cell
20
4153-4161
2009
Homo sapiens
brenda
Hartkamp, J.; Carpenter, B.; Roberts, S.G.
The Wilms tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi
Mol. Cell
37
159-171
2010
Homo sapiens, Mus musculus
brenda
Kawamoto, Y.; Ito, H.; Kobayashi, Y.; Suzuki, Y.; Akiguchi, I.; Fujimura, H.; Sakoda, S.; Kusaka, H.; Hirano, A.; Takahashi, R.
HtrA2/Omi-immunoreactive intraneuronal inclusions in the anterior horn of patients with sporadic and SOD1 mutant amyotrophic lateral sclerosis
Neuropathol. Appl. Neurobiol.
36
331-344
2010
Homo sapiens
brenda
Narkiewicz, J.; Lapinska-Szumczyk, S.; Zurawa-Janicka, D.; Skorko-Glonek, J.; Emerich, J.; Lipinska, B.
Expression of human HtrA1, HtrA2, HtrA3 and TGF-beta1 genes in primary endometrial cancer
Oncol. Rep.
21
1529-1537
2009
Homo sapiens
brenda
Li, B.; Hu, Q.; Wang, H.; Man, N.; Ren, H.; Wen, L.; Nukina, N.; Fei, E.; Wang, G.
Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases
Cell Death Differ.
17
1773-1784
2010
Mus musculus
brenda
Essafi, A.; Hastie, N.D.
WT1 the oncogene: a tale of death and HtrA
Mol. Cell
37
153-155
2010
Homo sapiens
brenda
Liu, Q.B.; Liu, L.L.; Lu, Y.M.; Tao, R.R.; Huang, J.Y.; Shioda, N.; Moriguchi, S.; Fukunaga, K.; Han, F.; Lou, Y.J.
The induction of reactive oxygen species and loss of mitochondrial Omi/HtrA2 is associated with S-nitrosoglutathione-induced apoptosis in human endothelial cells
Toxicol. Appl. Pharmacol.
244
374-384
2010
Homo sapiens
brenda
Park, D.W.; Nam, M.K.; Rhim, H.
The serine protease HtrA2 cleaves UCH-L1 and inhibits its hydrolase activity: Implication in the UCH-L1-mediated cell death
Biochem. Biophys. Res. Commun.
415
24-29
2011
Mus musculus
brenda
Vande Walle, L.; Wirawan, E.; Lamkanfi, M.; Festjens, N.; Verspurten, J.; Saelens, X.; Vanden Berghe, T.; Vandenabeele, P.
The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal
Cell Res.
20
421-433
2010
Mus musculus
brenda
Chien, J.
WT1 as a substrate of HtrA2: A potential pathway for therapeutic targeting by HtrA proteases
Future Oncol.
6
1233-1235
2010
Homo sapiens
brenda
Wysocka, M.; Wojtysiak, A.; Okonska, M.; Gruba, N.; Jarzab, M.; Wenta, T.; Lipinska, B.; Grzywa, R.; Sienczyk, M.; Rolka, K.; Lesner, A.
Design and synthesis of new substrates of HtrA2 protease
Anal. Biochem.
475
44-52
2015
Homo sapiens (O43464)
brenda
Sosna, J.; Voigt, S.; Mathieu, S.; Kabelitz, D.; Trad, A.; Janssen, O.; Meyer-Schwesinger, C.; Schuetze, S.; Adam, D.
The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis
Cell Commun. Signal.
11
76
2013
Mus musculus (Q9JIY5)
brenda
Zurawa-Janicka, D.; Jarzab, M.; Polit, A.; Skorko-Glonek, J.; Lesner, A.; Gitlin, A.; Gieldon, A.; Ciarkowski, J.; Glaza, P.; Lubomska, A.; Lipinska, B.
Temperature-induced changes of HtrA2(Omi) protease activity and structure
Cell Stress Chaperones
18
35-51
2013
Homo sapiens (O43464)
brenda
Singh, N.; DSouza, A.; Cholleti, A.; Sastry, G.M.; Bose, K.
Dual regulatory switch confers tighter control on HtrA2 proteolytic activity
FEBS J.
281
2456-2470
2014
Homo sapiens (O43464)
brenda
Luo, F.; Wei, L.; Sun, C.; Chen, X.; Wang, T.; Li, Y.; Liu, Z.; Chen, Z.; Xu, P.
HtrA2/Omi is involved in 6-OHDA-induced endoplasmic reticulum stress in SH-SY5Y cells
J. Mol. Neurosci.
47
120-127
2012
Homo sapiens (O43464), Homo sapiens
brenda
Bejugam, P.; Kuppili, R.; Singh, N.; Gadewal, N.; Chaganti, L.; Sastry, G.; Bose, K.
Allosteric regulation of serine protease HtrA2 through novel non-canonical substrate binding pocket
PLoS ONE
8
e55416
2013
Homo sapiens (O43464)
brenda
Suwannaboon, R.; Phiwsaiya, K.; Senapin, S.; Khunrae, P.; Rattanarojpong, T.
The identification and expression of the full-length HtrA2 gene from Penaeus monodon (black tiger shrimp)
Protein Expr. Purif.
92
183-189
2013
Penaeus monodon (U3N4T1)
brenda
Winkler, J.; Rand, M.L.; Schmugge, M.; Speer, O.
Omi/HtrA2 and XIAP are components of platelet apoptosis signalling
Thromb. Haemost.
109
532-539
2013
Homo sapiens (O43464)
brenda
Wysocka, M.; Wojtysiak, A.; Okonska, M.; Gruba, N.; Jarzab, M.; Wenta, T.; Lipinska, B.; Grzywa, R.; Sienczyk, M.; Rolka, K.; Lesner, A.
Design and synthesis of new substrates of HtrA2 protease
Anal. Biochem.
475
44-52
2015
Homo sapiens (O43464)
brenda
Jarzab, M.; Wenta, T.; Zurawa-Janicka, D.; Polit, A.; Gieldon, A.J.; Wysocka, M.; Glaza, P.; Skorko-Glonek, J.; Ciarkowski, J.; Lesner, A.; Lipinska, B.
Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer
Biochim. Biophys. Acta
1864
283-296
2016
Homo sapiens (O43464)
brenda
Wagh, A.R.; Bose, K.
Structural basis of inactivation of human counterpart of mouse motor neuron degeneration 2 mutant in serine protease HtrA2
Biosci. Rep.
38
BSR20181072
2018
Homo sapiens (O43464), Homo sapiens
brenda
Merski, M.; Moreira, C.; Abreu, R.M.; Ramos, M.J.; Fernandes, P.A.; Martins, L.M.; Pereira, P.J.B.; Macedo-Ribeiro, S.
Molecular motion regulates the activity of the mitochondrial serine protease HtrA2
Cell Death Dis.
8
e3119
2017
Homo sapiens (O43464), Homo sapiens
brenda
Hu, Y.; Bi, Y.; Yao, D.; Wang, P.; Li, Y.
Omi/HtrA2 protease associated cell apoptosis participates in blood-brain barrier dysfunction
Front. Mol. Neurosci.
12
48
2019
Homo sapiens (O43464), Homo sapiens
brenda
Sun, M.L.; Sun, L.M.; Wang, Y.Q.
Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes
J. Mol. Recognit.
31
e2698
2018
Homo sapiens (O43464)
brenda
Lucotte, B.; Tajhizi, M.; Alkhatib, D.; Samuelsson, E.; Wiehager, B.; Schedin-Weiss, S.; Sundstrom, E.; Winblad, B.; Tjernberg, L.; Behbahani, H.
Stress conditions increase vimentin cleavage by Omi/HtrA2 protease in human primary neurons and differentiated neuroblastoma cells
Mol. Neurobiol.
52
1077-1092
2015
Homo sapiens (O43464), Homo sapiens
brenda
Glaza, P.; Osipiuk, J.; Wenta, T.; Zurawa-Janicka, D.; Jarzab, M.; Lesner, A.; Banecki, B.; Skorko-Glonek, J.; Joachimiak, A.; Lipinska, B.
Structural and functional analysis of human HtrA3 protease and its subdomains
PLoS ONE
10
e0131142
2015
Homo sapiens (P83110)
brenda
Gieldon, A.; Zurawa-Janicka, D.; Jarzab, M.; Wenta, T.; Golik, P.; Dubin, G.; Lipinska, B.; Ciarkowski, J.
Distinct 3D architecture and dynamics of the human HtrA2(Omi) protease and its mutated variants
PLoS ONE
11
e0161526
2016
Homo sapiens (O43464), Homo sapiens
brenda
Rodrigue-Gervais, I.G.; Doiron, K.; Champagne, C.; Mayes, L.; Leiva-Torres, G.A.; Vanie, P.; Douglas, T.; Vidal, S.M.; Alnemri, E.S.; Saleh, M.
The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes
Sci. Rep.
8
8446
2018
Mus musculus (Q9JIY5)
brenda