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(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid + H2O
(10R,11R,12S)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoic acid
(11S,12S)-epoxy-5,14-cis-7,9-trans-eicosatetraenoic acid + H2O
(11R,12S)-dihydroxy-5,14-cis-7,9-trans-eicosatetraenoic acid + H2O
-
i.e. 11,12-leukotriene A4
-
?
(12Z)-9,10-epoxyoctadec-12-enoic acid
(12Z)-9,10-dihydroxyoctadec-12-enoic acid
-
-
-
?
(1S,2S)-beta-methylstyrene oxide + H2O
?
enzyme attacks almost exclusively at the benzylic position
-
-
?
(1S,2S)-trans-methylstyrene oxide + H2O
?
a hydrogen bond from Tyr465 to the substrate oxygen is essential for controlling the regioselectivity of the reaction
-
-
r
(3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester + H2O
6-methoxy-2-naphthaldehyde + ?
-
substrate for high-throughput screen
product is fluorescent
-
?
(3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester + H2O
?
-
-
-
-
?
(3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxynaphthalen-2-yl)-methyl ester + H2O
6-methoxy-2-naphthaldehyde + ?
-
-
-
-
?
(5Z,11Z,14Z)-8,9-epoxyeicosa-5,11,14-trienoic acid + H2O
(5Z,11Z,14Z)-8,9-dihydroxyeicosa-5,11,14-trienoic acid
(5Z,11Z,14Z)-8,9-epoxyeicosa-8,11,14-trienoic acid + H2O
(5Z,11Z,14Z)-8,9-dihydroxyeicosa-5,11,14-trienoic acid
-
-
-
?
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O
(5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
(5Z,8Z)-N-((2-methoxy-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)sulfonyl)-10-(3-((Z)-oct-2-en-1-yl)oxiran-2-yl)deca-5,8-dienamide + H2O
?
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
(5Z,8Z,11Z)-N-((2-methoxy-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl) sulfonyl)-13-(3-pentyloxiran-2-yl)trideca-5,8,11-trienamide + H2O
?
-
-
-
?
(5Z,8Z,11Z,14R,15S)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O
(5Z,8Z,11Z,14R,15R)-14,15-dihydroxyeicosa-5,8,11-trienoic acid + (5Z,8Z,11Z,14S,15S)-14,15-dihydroxyeicosa-5,8,11-trienoic acid
-
-
-
-
?
(5Z,8Z,11Z,14S,15R)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O
(5Z,8Z,11Z,14R,15R)-14,15-dihydroxyeicosa-5,8,11-trienoic acid + (5Z,8Z,11Z,14S,15S)-14,15-dihydroxyeicosa-5,8,11-trienoic acid
-
-
-
-
?
(5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O
(5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid + H2O
(8R,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoic acid
(8Z,11Z,14Z)-5,6-epoxyeicosa-8,11,14-trienoic acid + H2O
(8Z,11Z,14Z)-5,6-dihydroxyeicosa-8,11,14-trienoic acid
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O
(8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
(9Z)-12,13-epoxyoctadec-9-enoic acid + H2O
(9Z)-12,13-dihydroxyoctadec-9-enoic acid
-
-
-
?
(9Z)-12,13-epoxyoctadecenoic acid + H2O
(9Z)-12,13-dihydroxyoctadecenoic acid
(R)-1-chloro-2-(2,4-difluorophenyl)-2,3-epoxypropane + H2O
(R)-3-chloro-2-(2,4-difluoro-phenyl)-propane-1,2-diol
-
in a racemic mixture only the (R)-enantiomeric epoxide is converted to the (R)-enantiomeric diol
-
-
?
(R)-4-nitrostyrene oxide + H2O
?
(R)-glycidyl phenyl ether + H2O
?
(R)-p-nitrostyrene oxide + H2O
1-(4-nitrophenyl)ethane-1,2-diol
(R)-styrene oxide + H2O
(R)-styrene glycol
(R)-styrene oxide + H2O
1-phenylethane-1,2-diol
(R,S)-4-nitrostyrene oxide + H2O
1-(4-nitrophenyl)ethane-1,2-diol
-
-
-
-
?
(S)-4-nitrostyrene oxide
1-(4-nitrophenyl)ethane-1,2-diol
-
-
-
-
?
(S)-p-nitrostyrene oxide + H2O
1-(4-nitrophenyl)ethane-1,2-diol
(S)-styrene oxide + H2O
(S)-phenyl-1,2-ethanediol
wild-type and mutant enzymes prefer the S-enantiomer, enantioselective hydrolytic activity of sEH
-
-
?
(S)-styrene oxide + H2O
(S)-styrene glycol
(S)-styrene oxide + H2O
1-phenylethane-1,2-diol
preferred attack at the benzylic position
-
-
?
(S)-styrene oxide + H2O
?
1,2,3,4,9,9-hexachloro-6,7-epoxy-1,4,41,5,6,7,8,8a-octahydro-1,4-methanonaphthalene + H2O
?
1,3-trans-diphenylpropene oxide + H2O
1,3-diphenylpropane-1,2-diol
1-myristoyl-sn-glycerol 3-phosphate + H2O
?
-
-
-
?
11,12-epoxy-eicosatrienoic acid + H2O
11,12-dihydroxy-eicosatrienoic acid
-
-
-
?
11,12-epoxyeicosatrienoic acid + H2O
11,12-dihydroxyeicosatrienoic acid
11,12-leukotriene A4 + H2O
?
-
-
-
-
?
11R,12S-epoxyeicosatrienoic acid + H2O
11R,12S-dihydroxyeicosatrienoic acid
-
-
-
?
11S,12R-epoxyeicosatrienoic acid + H2O
11S,12R-hydroxyeicosatrienoic acid
-
-
-
?
12,13-cis-epoxy-octadeca-9E-enoic acid + H2O
?
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
?
12,13-trans-epoxy-octadeca-9E-enoic acid + H2O
?
-
-
-
?
12-phosphonooxyoctadec-9E-enoic acid + H2O
(9E)-octadecenoic acid + phosphate
-
-
-
-
?
12-phosphonooxyoctadec-9Z-enoic acid + H2O
(9Z)-octadecenoic acid + phosphate
-
-
-
-
?
12-phosphonooxyoctadecanoic acid + H2O
octadecanoic acid + phosphate
-
-
-
-
?
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoic acid + H2O
14,15-dihydroxyeicosatrienoic acid
-
-
-
?
14,15-epoxyeicosatrienoic acid + H2O
14,15-dihydroxyeicosatrienoic acid
14,15-leukotriene A4 + H2O
?
-
-
-
-
?
14R,15S-epoxyeicosatrienoic acid + H2O
14R,15S-dihydroxyeicosatrienoic acid
-
-
-
?
14S,15R-epoxy-eicosatrienoic acid + H2O
14S,15R-dihydroxy-eicosatrienoic acid
-
-
-
?
14S,15R-epoxyeicosatrienoic acid + H2O
14S,15R-dihydroxyeicosatrienoic acid
-
-
-
?
14S,15S-trans-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoic acid + H2O
14S,15R-dihydroxy-(5Z,8Z,10E,12E)-eicosatetraenoic acid
-
-
-
?
2,2-dimethylstyrene oxide + H2O
?
-
-
-
-
?
2,3-epoxy-1,3-diphenyl-propane + H2O
?
2,3-squalene oxide + H2O
?
2-acetylaminofluorene + H2O
?
2-methyl styrene oxide + H2O
(2R)-2-phenylpropane-1,2-diol
-
-
highly enantioselective in ionic liquid [bmim][PF6]in presence of 10% water
-
?
2-methylphenyl glycidyl ether + H2O
?
3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester 2-oxiraneacetic acid + H2O
6-methoxy-2-naphthaldehyde + ?
-
-
-
-
?
3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester-2-oxiraneacetic acid + H2O
6-methoxy-2-naphtaldehyde + ?
-
-
-
?
3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester-2-oxiraneacetic acid + H2O
6-methoxy-2-naphthaldehyde + ?
fluorometric activity assay substrate
-
-
?
3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester-2-oxiraneacetic acid + H2O
6-methoxynaphthaldehyde + ?
-
-
-
-
?
3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester-2-oxiraneacetic acid + H2O
?
-
-
-
?
3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methylester-2-oxirane-acetic acid + H2O
6-methoxynaphtaldehyde + ?
the non-fluorescent substrate can be hydrolyzed by enzyme sEH to the fluorescent 6-methoxynaphtaldehyde
-
-
?
3-phenyl-oxiranyl-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester + H2O
?
-
-
-
-
?
3-phenylcyano-(6-methoxy-2-naphthalenyl)methyl ester 2-oxiraneacetic acid + H2O
?
-
-
-
?
4-chlorostyrene oxide + H2O
(1R)-1-(4-chlorophenyl)ethane-1,2-diol
-
-
conversion of racemic substrate via attack of the benzylic position to R-diol with 96% enantiomeric excess
-
?
4-methylphenylglycidyl ether + H2O
?
4-nitrophenyl (2R,3R)-2,3-epoxy-3-(4-nitrophenyl)propyl carbonate + H2O
?
-
-
-
-
?
4-nitrophenyl (2R,3R)-2,3-epoxy-3-phenylpropyl carbonate + H2O
?
4-nitrophenyl (2S,3S)-2,3-epoxy-3-(4-nitrophenyl)propyl carbonate + H2O
?
-
preferred phenylpropyl carbonate substrate
-
-
?
4-nitrophenyl (2S,3S)-2,3-epoxy-3-phenylpropyl carbonate + H2O
?
-
-
-
-
?
4-nitrophenyl [(2R,3R)-3-phenyloxiran-2-yl]methyl carbonate + H2O
?
-
15.2% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
4-nitrophenyl [(2S,3S)-3-phenyloxiran-2-yl]methyl carbonate + H2O
?
-
38% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
4-nitrophenyl-trans-2,3-epoxy-3-phenylpropyl carbonate + H2O
?
4-nitrostyrene 7,8-oxide + H2O
?
4-nitrostyrene oxide + H2O
(1R)-1-(4-nitrophenyl)ethane-1,2-diol
-
-
conversion of racemic substrate via attack of the benzylic position to R-diol with 80% enantiomeric excess
-
?
4-nitrostyrene oxide + H2O
?
4-t-butylstyrene oxide + H2O
(1R)-1-(4-t-butylphenyl)ethane-1,2-diol
-
-
highly enantioselective in ionic liquid [bmim][PF6]in presence of 10% water
-
?
5,6-epoxyeicosatrienoic acid + H2O
5,6-dihydroxyeicosatrienoic acid
5,6-epoxyeicosatrienoic acid + H2O
5,6-hydroxyeicosatrienoic acid
5,6-leukotriene A4 + H2O
?
-
-
-
-
?
5alpha-cholest-2-ene beta-oxide + H2O
?
-
-
-
-
?
6,8-difluoro-4-methylumbelliferyl trans-2,3-epoxy-3-phenylpropylcarbonate + H2O
?
-
-
-
?
8,9-epoxyeicosatrienoic acid + H2O
8,9-dihydroxyeicosatrienoic acid
8,9-epoxyeicosatrienoic acid + H2O
8,9-hydroxyeicosatrienoic acid
-
-
-
-
?
8R,9S-epoxyeicosatrienoic acid + H2O
8R,9S-dihydroxyeicosatrienoic acid
-
-
-
?
8S,9R-epoxyeicosatrienoic acid + H2O
8S,9R-dihydroxyeicosatrienoic acid
-
-
-
?
9(10),12(13)-diepoxyoctadecanoic acid + H2O
9,10,12,13-tetrahydroxyoctadecanoic acid
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
?
9R,10R-trans-epoxy-13R-hydroxy-11E-octadecenoic acid + H2O
(9R,10S,13R)-trihydroxy-11E-octadecenoic acid
9R,10S-cis-epoxy-13R-hydroxy-11E-octadecenoic acid
(9R,10R,13R)-trihydroxy-11E-octadecenoic acid
-
-
-
?
9R,10S-cis-epoxy-13R-hydroxy-11E-octadecenoic acid + H2O
(9R,10R,13R)-trihydroxy-11E-octadecenoic acid
-
-
-
?
alpha-cyanocarbonate epoxide + H2O
?
arachidonic acid 11,12-oxide + H2O
11,12-dihydroxyarachidonic acid
-
-
-
-
?
arachidonic acid 14,15-oxide + H2O
14,15-dihydroxyarachidonic acid
-
-
-
-
?
arachidonic acid 5,6-oxide + H2O
5,6-dihydroxyarachidonic acid
-
-
-
-
?
arachidonic acid 8,9-oxide + H2O
8,9-dihydroxyarachidonic acid
-
-
-
-
?
benzopyrene 4,5-oxide + H2O
(-)benzopyrene 4,5-dihydrodiol
cholesterol 5,6-alpha-oxide + H2O
?
-
very weak activity
-
-
?
cis-(9R,10S)-epoxystearic acid + H2O
threo-(9R,10R)-dihydroxystearic acid + threo-(9S,10S)-dihydroxystearic acid
-
-
enantioselective, low production rate of the (9R,10R)-diol by wild-type and E404D mutant
-
?
cis-(9S,10R)-epoxystearic acid + H2O
threo-(9R,10R)-dihydroxystearic acid + threo-(9S,10S)-dihydroxystearic acid
-
-
enantioselective, low production rate of the (9R,10R)-diol by wild-type and E404D mutant
-
?
cis-1,2-dimethylstyrene oxide + H2O
?
-
-
-
-
?
cis-1,3-diphenylpropene oxide + H2O
1,3-diphenylpropane-1,2-diol
cis-1,3-diphenylpropene oxide + H2O
?
cis-11,12-epoxyeicosatrienoic acid + H2O
?
-
-
-
-
?
cis-11,12-epoxyeicosatrienoic acid + H2O
cis-11,12-dihydroxyeicosatrienoic acid
-
-
-
?
cis-14,15-epoxyeicosatrienoic acid + H2O
?
cis-14,15-epoxyeicosatrienoic acid + H2O
cis-14,15-dihydroxyeicosatrienoic acid
cis-2-methylstyrene oxide + H2O
?
-
-
-
-
?
cis-8,9-epoxyeicosatrienoic acid + H2O
?
-
-
-
-
?
cis-8,9-epoxyeicosatrienoic acid + H2O
cis-8,9-dihydroxyeicosatrienoic acid
-
-
-
?
cis-8-ethylstyrene 7,8-oxide + H2O
?
cis-9,10-epoxy-12-octadecenoate methyl ester + H2O
9,10-dihydroxystearic acid methyl ester
cis-9,10-epoxy-12-octadecenoate methyl ester + H2O
?
-
5.2% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
cis-9,10-epoxystearate + H2O
threo-9,10-dihydroxystearate
-
-
-
?
cis-9,10-epoxystearic acid + H2O
9,10-dihydroxystearic acid
cis-9,10-epoxystearic acid + H2O
?
-
7.9% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
cis-stilbene oxide + H2O
(1R,2R)-1,2-diphenylethane-1,2-diol
cis-stilbene oxide + H2O
1,2-diphenylethane-1,2-diol
cis-stilbene oxide + H2O
?
cyano(2-methoxy-naphthalen-6-yl)methyl trans-2-(3-propyloxiran-2-yl) acetate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxiran-2-yl)methyl carbonate + H2O
?
a fluorogenic substrate
-
-
?
cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyloxiran-2-yl)methylcarbonate + H2O
?
-
-
-
-
?
cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl)methyl carbonate + H2O
?
-
-
-
-
?
cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl)methylcarbonate + H2O
6-methoxy-2-naphthaldehyde + ?
fluorometric activity assay substrate
-
-
?
cyano(2-methoxynaphthalen-6-yl)methyl(3-phenyloxiran-2-yl)methyl carbonate + H2O
?
-
-
-
-
?
cyano(6-methoxy-2-naphthyl)methyl (3,3-dimethyloxiran-2-yl)methyl carbonate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
cyano(6-methoxy-2-naphthyl)methyl (3-ethyloxiran-2-yl)methyl carbonate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)acetate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)methyl carbonate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
cyano(6-methoxy-2-naphthyl)methyl (3-propyloxiran-2-yl)methyl carbonate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
cyano(6-methoxy-2-naphthyl)methyl [3-(4-nitrophenyl)oxiran-2-yl]methyl carbonate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate + H2O
?
cyano(6-methoxynaphthalen-2-yl)methyl (3-phenyloxiran-2-yl)acetate + H2O
[1,2-dihydroxy-2-(3-phenyloxiran-2-yl)ethoxy](6-methoxynaphthalen-2-yl)acetonitrile
cyano-(2-methoxynaphthalen-6-yl)-methyl trans-(3-phenyl-oxiran-2-yl)-methyl carbonate + H2O
?
cyclohexene oxide + H2O
?
di(2-ethylhexyl)phthalate + H2O
?
dihydronaphthalene oxide + H2O
(1S,2S)-1,2,3,4-tetrahydronaphthalene-1,2-diol
-
-
highly enantioselective in ionic liquid [bmim][PF6]in presence of 10% water
-
?
Epoxy Fluor 7 + H2O
?
i.e. cyano(6-methoxy-2-naphthalenyl)methyl[(2,3)-3-phenyloxiranyl]methyl ester
-
-
?
epoxy stearic acid + H2O
?
epoxyeicosatrienoic acid + H2O
dihydroxyeicosatrienoic acid
erythro-10-hydroxy-9-phosphonooxy-octadecanoic acid + H2O
10-hydroxy-octadecanoic acid + phosphate
-
-
-
-
?
glycidyl phenyl ether + H2O
?
-
the selectivity factor E reflecting the relative rate of the reaction of the two enantiomers is only 4.6 for the wild-type enzyme, in slight favor of the (S)-product, a value of 10.8 is observed with the natural EH variant IS002B1 with the three amino acid exchanges A217V, K332E and A390E. A value of 7.4 is observed with the natural variant IR003B1 with the amino acid exchange R219G, a value of 6.6 is observed with the natural variant IB001C2 with the amino acid exchange F340Y, a value of 6.4 is observed with the natural variant IE001H6 with the amino acid exchange A327V, a value of 6.2 is observed with the natural variant IS001H8 with the amino acid exchange A327V and a value of 5.5 is observed with the natural variant IL001D4 with the amino acid exchange P222S
-
-
?
juvenile hormone III + H2O
?
lanosterol + H2O
?
-
-
-
-
?
leukotoxin + H2O
leukotoxin diol
leukotoxin + H2O
leukotoxin-1,2-diol
-
-
-
?
leukotriene A4 + H2O
5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid
-
-
i.e. compound D, product identification by GC-MS
-
?
naphthalene 1,2-oxide + H2O
?
p-nitrophenyl phosphate + H2O
?
-
-
-
-
?
p-nitrostyrene oxide + H2O
?
-
-
-
-
?
phenanthrene-9,10-oxide + H2O
?
rac trans-1,3-diphenylpropene oxide + H2O
?
racemic 4-nitrophenyl-trans-2,3-epoxy-3-phenylpropyl carbonate + H2O
?
racemic ethyl 3-phenylglycidate + H2O
?
racemic trans-1,3-diphenylpropene oxide + H2O
?
-
-
-
-
?
squalene 2,3-23,24-dioxide + H2O
?
-
-
-
-
?
squalene diepoxide + H2O
?
-
-
-
?
squalene oxide + H2O
?
-
weak substrate
-
-
?
squalene-2,3-epoxide + H2O
?
-
-
-
?
stearic acid epoxide + H2O
?
-
-
-
-
?
styrene 7,8-oxide + H2O
?
styrene 7,8-oxide + H2O
styrene glycol
styrene oxide + H2O
(1R)-1-phenylethane-1,2-diol
-
-
conversion of racemic substrate via attack of the benzylic position to R-diol with 90% enantiomeric excess
-
?
styrene oxide + H2O
styrene glycol
threo-10-hydroxy-9-phosphonooxy-octadecanoic acid + H2O
10-hydroxy-octadecanoic acid + phosphate
-
-
-
-
?
trans-1,2-dimethylstyrene oxide + H2O
?
-
hydration by microsomal enzyme, no activity with cytosolic enzyme
-
-
?
trans-1,3-diphenylpropene oxide + H2O
1,3-diphenylpropane-1,2-diol
trans-1,3-diphenylpropene oxide + H2O
?
trans-1,3-diphenylpropene oxide + H2O
trans-1,3-diphenylpropane-1,2-diol
-
-
-
?
trans-2-methylstyrene oxide + H2O
?
trans-8-ethylstyrene 7,8-oxide + H2O
?
trans-9,10-epoxystearate + H2O
?
trans-9,10-epoxystearate + H2O
threo-9,10-dihydroxystearate
-
-
-
?
trans-beta-methyl-styrene oxide + H2O
?
trans-beta-methylstyrene oxide + H2O
?
-
-
-
-
?
trans-beta-propylstyrene oxide + H2O
?
-
-
-
-
?
trans-diphenyl propene oxide + H2O
?
-
-
-
-
?
trans-diphenyl-propene oxide + H2O
?
-
-
-
?
trans-diphenyl-propene oxide + H2O
trans-diphenyl-propene diol
trans-diphenylpropene oxide + H2O
?
trans-ethyl styrene oxide + H2O
?
trans-stilbene oxide + H2O
1,2-diphenylethane-1,2-diol
trans-stilbene oxide + H2O
?
[3-(4-chlorophenyl)oxiran-2-yl]methyl cyano(6-methoxy-2-naphthyl)methyl carbonate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
additional information
?
-
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid + H2O
(10R,11R,12S)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoic acid
-
i.e. hepoxilin B3
-
-
?
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid + H2O
(10R,11R,12S)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoic acid
-
i.e. hepoxilin B3
-
-
?
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid + H2O
(10R,11R,12S)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoic acid
-
i.e. hepoxilin B3
-
-
?
(5Z,11Z,14Z)-8,9-epoxyeicosa-5,11,14-trienoic acid + H2O
(5Z,11Z,14Z)-8,9-dihydroxyeicosa-5,11,14-trienoic acid
-
i.e. 8,9-EET
i.e. 8,9-DHET
-
?
(5Z,11Z,14Z)-8,9-epoxyeicosa-5,11,14-trienoic acid + H2O
(5Z,11Z,14Z)-8,9-dihydroxyeicosa-5,11,14-trienoic acid
-
i.e. 8,9-EET
i.e. 8,9-DHET
-
?
(5Z,11Z,14Z)-8,9-epoxyeicosa-5,11,14-trienoic acid + H2O
(5Z,11Z,14Z)-8,9-dihydroxyeicosa-5,11,14-trienoic acid
i.e. 8,9-EET
i.e. 8,9-DHET
-
?
(5Z,11Z,14Z)-8,9-epoxyeicosa-5,11,14-trienoic acid + H2O
(5Z,11Z,14Z)-8,9-dihydroxyeicosa-5,11,14-trienoic acid
-
i.e. 8,9-EET
i.e. 8,9-DHET
-
?
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O
(5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O
(5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
-
-
-
?
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O
(5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O
(5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O
(5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
-
-
-
?
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O
(5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O
(5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid
-
i.e. 14,15-EET
i.e. 14,15-DHET
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid
binding structure in the active site, docking analysis and molecular dynamics simulations
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid
-
i.e. 14,15-EET
i.e. 14,15-DHET
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid
i.e. 14,15-EET
i.e. 14,15-DHET
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid
-
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid
-
i.e. 14,15-EET
i.e. 14,15-DHET
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
enzyme-substrate binding, overview
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
preferred substrate
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
i.e. EETs, showing endothelium-derived hyperpolarizing factor effects dominating in microvessels independent of nitric oxide and prostacyclin. sEH reduces the beneficial effects of EETs
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
enzyme-substrate binding, overview
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
14,15-epoxyeicosatrienoic acid, i.e. 14,15-EET, is cytoprotective in vivo, which is in part mediated by STAT3, overview
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
i.e. 14,15-EET, EETs have antiinflammatory effects and are required for normal endothelial function
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
i.e. EETs, showing endothelium-derived hyperpolarizing factor effects dominating in microvessels independent of nitric oxide and prostacyclin. sEH reduces the beneficial effects of EETs
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
EETs exhibit a wide array of potentially beneficial actions in stroke, including vasodilation, neuroprotection, promotion of angiogenesis and suppression of platelet aggregation, oxidative stress and postischemic inflammation
-
-
?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
i.e. EETs, showing endothelium-derived hyperpolarizing factor effects dominating in microvessels independent of nitric oxide and prostacyclin. sEH reduces the beneficial effects of EETs
-
-
?
(5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O
(5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid
-
i.e. 11,12-EET
i.e. 11,12-DHET
-
?
(5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O
(5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid
-
i.e. 11,12-EET
i.e. 11,12-DHET
-
?
(5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O
(5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid
i.e. 11,12-EET
i.e. 11,12-DHET
-
?
(5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O
(5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid
-
i.e. 11,12-EET
i.e. 11,12-DHET
-
?
(5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O
(5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid
-
-
-
?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
-
-
-
?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
preferred substrate
-
-
?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
-
-
-
?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
-
-
?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
-
-
?
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid + H2O
(8R,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoic acid
-
i.e. hepoxilin A3, hydrolysis in liver is mainly catalyzed by soluble epoxide hydrolase
-
-
?
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid + H2O
(8R,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoic acid
-
i.e. hepoxilin A3, hydrolysis in liver is mainly catalyzed by soluble epoxide hydrolase
-
-
?
(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoic acid + H2O
(8R,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoic acid
-
i.e. hepoxilin A3, hydrolysis in liver is mainly catalyzed by soluble epoxide hydrolase
-
-
?
(8Z,11Z,14Z)-5,6-epoxyeicosa-8,11,14-trienoic acid + H2O
(8Z,11Z,14Z)-5,6-dihydroxyeicosa-8,11,14-trienoic acid
-
i.e. 5,6-EET
i.e. 5,6-DHET
-
?
(8Z,11Z,14Z)-5,6-epoxyeicosa-8,11,14-trienoic acid + H2O
(8Z,11Z,14Z)-5,6-dihydroxyeicosa-8,11,14-trienoic acid
-
i.e. 5,6-EET
i.e. 5,6-DHET
-
?
(8Z,11Z,14Z)-5,6-epoxyeicosa-8,11,14-trienoic acid + H2O
(8Z,11Z,14Z)-5,6-dihydroxyeicosa-8,11,14-trienoic acid
i.e. 5,6-EET
i.e. 5,6-DHET
-
?
(8Z,11Z,14Z)-5,6-epoxyeicosa-8,11,14-trienoic acid + H2O
(8Z,11Z,14Z)-5,6-dihydroxyeicosa-8,11,14-trienoic acid
-
i.e. 5,6-EET
i.e. 5,6-DHET
-
?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O
(8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
-
-
?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O
(8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
-
-
-
?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O
(8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
-
-
?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O
(8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
-
-
?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O
(8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
-
-
-
?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O
(8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
-
-
?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O
(8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
-
-
?
(9Z)-12,13-epoxyoctadecenoic acid + H2O
(9Z)-12,13-dihydroxyoctadecenoic acid
-
-
-
?
(9Z)-12,13-epoxyoctadecenoic acid + H2O
(9Z)-12,13-dihydroxyoctadecenoic acid
-
-
-
?
(R)-4-nitrostyrene oxide + H2O
?
-
-
-
?
(R)-4-nitrostyrene oxide + H2O
?
-
-
-
?
(R)-glycidyl phenyl ether + H2O
?
-
the hydrolysis of (R)-epoxide in the presence of Tween-80 is 25.6 times faster than that of the (S)-epoxide
-
-
?
(R)-glycidyl phenyl ether + H2O
?
-
the hydrolysis of (R)-epoxide in the presence of Tween-80 is 25.6 times faster than that of the (S)-epoxide
-
-
?
(R)-p-nitrostyrene oxide + H2O
1-(4-nitrophenyl)ethane-1,2-diol
-
-
-
-
?
(R)-p-nitrostyrene oxide + H2O
1-(4-nitrophenyl)ethane-1,2-diol
-
-
-
-
?
(R)-p-nitrostyrene oxide + H2O
1-(4-nitrophenyl)ethane-1,2-diol
-
-
-
-
?
(R)-styrene oxide + H2O
(R)-styrene glycol
-
-
-
?
(R)-styrene oxide + H2O
(R)-styrene glycol
low activity, the enzyme enantioselective and preferentially hydrolyzes (S)-styrene oxide
-
-
?
(R)-styrene oxide + H2O
(R)-styrene glycol
low activity, the enzyme enantioselective and preferentially hydrolyzes (S)-styrene oxide
-
-
?
(R)-styrene oxide + H2O
1-phenylethane-1,2-diol
-
-
-
-
?
(R)-styrene oxide + H2O
1-phenylethane-1,2-diol
-
-
-
-
?
(S)-p-nitrostyrene oxide + H2O
1-(4-nitrophenyl)ethane-1,2-diol
-
-
-
-
?
(S)-p-nitrostyrene oxide + H2O
1-(4-nitrophenyl)ethane-1,2-diol
-
-
-
-
?
(S)-styrene oxide + H2O
(S)-styrene glycol
-
-
-
?
(S)-styrene oxide + H2O
(S)-styrene glycol
the enzyme possesses (S)-styrene oxide-preferred hydrolytic activity
-
-
?
(S)-styrene oxide + H2O
(S)-styrene glycol
the enzyme enantioselective and preferentially hydrolyzes (S)-styrene oxide
-
-
?
(S)-styrene oxide + H2O
(S)-styrene glycol
the enzyme enantioselective and preferentially hydrolyzes (S)-styrene oxide
-
-
?
(S)-styrene oxide + H2O
?
-
-
-
-
?
(S)-styrene oxide + H2O
?
-
-
-
-
?
1,2,3,4,9,9-hexachloro-6,7-epoxy-1,4,41,5,6,7,8,8a-octahydro-1,4-methanonaphthalene + H2O
?
-
i.e. HEOM
-
-
?
1,2,3,4,9,9-hexachloro-6,7-epoxy-1,4,41,5,6,7,8,8a-octahydro-1,4-methanonaphthalene + H2O
?
-
i.e. HEOM
-
-
?
1,2,3,4,9,9-hexachloro-6,7-epoxy-1,4,41,5,6,7,8,8a-octahydro-1,4-methanonaphthalene + H2O
?
-
i.e. HEOM
-
-
?
1,2,3,4,9,9-hexachloro-6,7-epoxy-1,4,41,5,6,7,8,8a-octahydro-1,4-methanonaphthalene + H2O
?
-
i.e. HEOM
-
-
?
1,2,3,4,9,9-hexachloro-6,7-epoxy-1,4,41,5,6,7,8,8a-octahydro-1,4-methanonaphthalene + H2O
?
-
i.e. HEOM
-
-
?
1,3-trans-diphenylpropene oxide + H2O
1,3-diphenylpropane-1,2-diol
-
little to no selectivity for cis-isomer or trans-isomer
-
-
?
1,3-trans-diphenylpropene oxide + H2O
1,3-diphenylpropane-1,2-diol
-
sEH-selective substrate
-
-
?
11,12-epoxyeicosatrienoic acid + H2O
11,12-dihydroxyeicosatrienoic acid
-
-
-
-
?
11,12-epoxyeicosatrienoic acid + H2O
11,12-dihydroxyeicosatrienoic acid
-
-
-
-
?
11,12-epoxyeicosatrienoic acid + H2O
11,12-dihydroxyeicosatrienoic acid
-
-
-
?
11,12-epoxyeicosatrienoic acid + H2O
11,12-dihydroxyeicosatrienoic acid
-
-
-
-
?
11,12-epoxyeicosatrienoic acid + H2O
11,12-dihydroxyeicosatrienoic acid
-
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
?
-
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
?
-
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
?
-
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
?
-
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
?
-
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
?
-
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
?
-
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
?
-
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
?
-
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
?
-
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
?
-
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
?
-
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
?
-
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
?
-
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
?
-
-
-
-
?
12,13-epoxy octadeca-(9Z)-eneoic acid + H2O
?
-
-
-
-
?
14,15-epoxyeicosatrienoic acid + H2O
14,15-dihydroxyeicosatrienoic acid
-
-
-
-
?
14,15-epoxyeicosatrienoic acid + H2O
14,15-dihydroxyeicosatrienoic acid
-
-
-
-
?
14,15-epoxyeicosatrienoic acid + H2O
14,15-dihydroxyeicosatrienoic acid
-
-
-
?
14,15-epoxyeicosatrienoic acid + H2O
14,15-dihydroxyeicosatrienoic acid
-
-
-
?
14,15-epoxyeicosatrienoic acid + H2O
14,15-dihydroxyeicosatrienoic acid
-
-
-
-
?
14,15-epoxyeicosatrienoic acid + H2O
14,15-dihydroxyeicosatrienoic acid
-
-
-
-
?
2,3-epoxy-1,3-diphenyl-propane + H2O
?
-
-
-
-
?
2,3-epoxy-1,3-diphenyl-propane + H2O
?
-
-
-
-
?
2,3-epoxy-1,3-diphenyl-propane + H2O
?
-
-
-
-
?
2,3-epoxy-1,3-diphenyl-propane + H2O
?
-
-
-
-
?
2,3-epoxy-1,3-diphenyl-propane + H2O
?
-
-
-
-
?
2,3-squalene oxide + H2O
?
-
-
-
-
?
2,3-squalene oxide + H2O
?
-
-
-
-
?
2,3-squalene oxide + H2O
?
-
-
-
-
?
2,3-squalene oxide + H2O
?
-
-
-
-
?
2,3-squalene oxide + H2O
?
-
-
-
-
?
2-acetylaminofluorene + H2O
?
-
-
-
-
?
2-acetylaminofluorene + H2O
?
-
-
-
-
?
2-acetylaminofluorene + H2O
?
-
-
-
-
?
2-acetylaminofluorene + H2O
?
-
-
-
-
?
2-acetylaminofluorene + H2O
?
-
-
-
-
?
2-methylphenyl glycidyl ether + H2O
?
-
-
-
-
?
2-methylphenyl glycidyl ether + H2O
?
-
-
-
-
?
4-methylphenylglycidyl ether + H2O
?
-
-
-
-
?
4-methylphenylglycidyl ether + H2O
?
-
-
-
-
?
4-nitrophenyl (2R,3R)-2,3-epoxy-3-phenylpropyl carbonate + H2O
?
-
14.6% of the activity with 2,3-epoxy-1,3-diphenyl-propane, no activity with the 2S,3S-enantiomer
-
-
?
4-nitrophenyl (2R,3R)-2,3-epoxy-3-phenylpropyl carbonate + H2O
?
-
-
-
-
?
4-nitrophenyl (2R,3R)-2,3-epoxy-3-phenylpropyl carbonate + H2O
?
-
5.1% of the activity with 2,3-epoxy-1,3-diphenyl-propane, no activity with the 2S,3S-enantiomer
-
-
?
4-nitrophenyl-trans-2,3-epoxy-3-phenylpropyl carbonate + H2O
?
-
-
-
-
?
4-nitrophenyl-trans-2,3-epoxy-3-phenylpropyl carbonate + H2O
?
-
-
-
?
4-nitrophenyl-trans-2,3-epoxy-3-phenylpropyl carbonate + H2O
?
-
-
-
-
?
4-nitrostyrene 7,8-oxide + H2O
?
-
i.e. PNSO
-
-
?
4-nitrostyrene 7,8-oxide + H2O
?
-
i.e. PNSO
-
-
?
4-nitrostyrene oxide + H2O
?
-
-
-
-
?
4-nitrostyrene oxide + H2O
?
-
-
-
-
?
4-nitrostyrene oxide + H2O
?
-
-
-
-
?
4-nitrostyrene oxide + H2O
?
-
-
-
-
?
4-nitrostyrene oxide + H2O
?
-
-
-
-
?
5,6-epoxyeicosatrienoic acid + H2O
5,6-dihydroxyeicosatrienoic acid
-
-
-
?
5,6-epoxyeicosatrienoic acid + H2O
5,6-dihydroxyeicosatrienoic acid
-
-
-
-
?
5,6-epoxyeicosatrienoic acid + H2O
5,6-hydroxyeicosatrienoic acid
-
-
-
-
?
5,6-epoxyeicosatrienoic acid + H2O
5,6-hydroxyeicosatrienoic acid
-
-
-
-
?
8,9-epoxyeicosatrienoic acid + H2O
8,9-dihydroxyeicosatrienoic acid
-
-
-
?
8,9-epoxyeicosatrienoic acid + H2O
8,9-dihydroxyeicosatrienoic acid
-
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
the enzyme prefers the (9R,10S)-enantiomer
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
the enzyme strongly prefers the (9R,10S)-enantiomer, conversion of the (S)-carbon to the corresponding threo-(R,R)-diol in over 85%
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
no enantioselectivity of infection-induced isozymes, conversion of the (S)-carbon to the corresponding threo-(R,R)-diol in over 85%
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
no enantioselectivity
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
the enzyme prefers the (9R,10S)-enantiomer, conversion of the (S)-carbon to the corresponding threo-(R,R)-diol in over 85%
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
no enantioselectivity
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
no enantioselectivity
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
?
-
step in cutin biosynthesis
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9,10-epoxy-18-hydroxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9-hydroxy-10,11-epoxy octadeca-(12Z)-eneoic acid + H2O
?
-
-
-
-
?
9R,10R-trans-epoxy-13R-hydroxy-11E-octadecenoic acid + H2O
(9R,10S,13R)-trihydroxy-11E-octadecenoic acid
-
-
-
?
9R,10R-trans-epoxy-13R-hydroxy-11E-octadecenoic acid + H2O
(9R,10S,13R)-trihydroxy-11E-octadecenoic acid
-
-
-
?
allylbenzene + H2O
?
-
-
-
-
?
allylbenzene + H2O
?
-
-
-
-
?
allylbenzene + H2O
?
-
-
-
-
?
alpha-cyanocarbonate epoxide + H2O
?
-
-
-
-
?
alpha-cyanocarbonate epoxide + H2O
?
-
-
-
-
?
arochlor 1254 + H2O
?
-
-
-
-
?
arochlor 1254 + H2O
?
-
-
-
-
?
arochlor 1254 + H2O
?
-
-
-
-
?
arochlor 1254 + H2O
?
-
-
-
-
?
arochlor 1254 + H2O
?
-
-
-
-
?
benzopyrene 4,5-oxide + H2O
(-)benzopyrene 4,5-dihydrodiol
-
-
-
-
?
benzopyrene 4,5-oxide + H2O
(-)benzopyrene 4,5-dihydrodiol
-
-
-
-
?
benzopyrene 4,5-oxide + H2O
(-)benzopyrene 4,5-dihydrodiol
-
-
-
-
?
benzopyrene 4,5-oxide + H2O
(-)benzopyrene 4,5-dihydrodiol
-
-
-
-
?
benzopyrene 4,5-oxide + H2O
(-)benzopyrene 4,5-dihydrodiol
-
-
-
-
?
chalcone oxides + H2O
?
-
-
-
-
?
chalcone oxides + H2O
?
-
-
-
-
?
chalcone oxides + H2O
?
-
-
-
-
?
cis-1,3-diphenylpropene oxide + H2O
1,3-diphenylpropane-1,2-diol
-
little to no selectivity for cis-isomer or trans-isomer, 99% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
cis-1,3-diphenylpropene oxide + H2O
1,3-diphenylpropane-1,2-diol
-
2.1% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
cis-1,3-diphenylpropene oxide + H2O
1,3-diphenylpropane-1,2-diol
-
little to no selectivity for cis-isomer or trans-isomer, 44% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
cis-1,3-diphenylpropene oxide + H2O
?
-
18.1% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
cis-1,3-diphenylpropene oxide + H2O
?
-
3.0% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
cis-14,15-epoxyeicosatrienoic acid + H2O
?
simulation of substrate binding, modeling
-
-
?
cis-14,15-epoxyeicosatrienoic acid + H2O
?
-
-
-
-
?
cis-14,15-epoxyeicosatrienoic acid + H2O
cis-14,15-dihydroxyeicosatrienoic acid
preferred eicosatrienoic acid-substrate
-
-
?
cis-14,15-epoxyeicosatrienoic acid + H2O
cis-14,15-dihydroxyeicosatrienoic acid
-
-
-
?
cis-14,15-epoxyeicosatrienoic acid + H2O
cis-14,15-dihydroxyeicosatrienoic acid
-
-
-
?
cis-14,15-epoxyeicosatrienoic acid + H2O
cis-14,15-dihydroxyeicosatrienoic acid
-
-
-
?
cis-14,15-epoxyeicosatrienoic acid + H2O
cis-14,15-dihydroxyeicosatrienoic acid
-
-
-
?
cis-8-ethylstyrene 7,8-oxide + H2O
?
-
-
-
-
?
cis-8-ethylstyrene 7,8-oxide + H2O
?
-
-
-
-
?
cis-9,10-epoxy-12-octadecenoate methyl ester + H2O
9,10-dihydroxystearic acid methyl ester
-
59% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
cis-9,10-epoxy-12-octadecenoate methyl ester + H2O
9,10-dihydroxystearic acid methyl ester
-
6.5% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
cis-9,10-epoxy-12-octadecenoate methyl ester + H2O
9,10-dihydroxystearic acid methyl ester
-
3.5% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
cis-9,10-epoxy-12-octadecenoate methyl ester + H2O
9,10-dihydroxystearic acid methyl ester
-
12% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
cis-9,10-epoxystearic acid + H2O
9,10-dihydroxystearic acid
-
30% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
cis-9,10-epoxystearic acid + H2O
9,10-dihydroxystearic acid
-
6.7% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
cis-9,10-epoxystearic acid + H2O
9,10-dihydroxystearic acid
-
4.1% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
cis-9,10-epoxystearic acid + H2O
9,10-dihydroxystearic acid
-
13.4% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
cis-stilbene oxide + H2O
(1R,2R)-1,2-diphenylethane-1,2-diol
-
-
-
-
?
cis-stilbene oxide + H2O
(1R,2R)-1,2-diphenylethane-1,2-diol
-
-
-
-
?
cis-stilbene oxide + H2O
1,2-diphenylethane-1,2-diol
-
activity is 50fold lower than with trans-stilbene oxide
-
-
?
cis-stilbene oxide + H2O
1,2-diphenylethane-1,2-diol
-
far greater selectivity for trans-stilbene oxide versus cis-stilbene oxide. 0.2% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
cis-stilbene oxide + H2O
1,2-diphenylethane-1,2-diol
-
low activity
-
-
?
cis-stilbene oxide + H2O
1,2-diphenylethane-1,2-diol
-
0.4% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
cis-stilbene oxide + H2O
1,2-diphenylethane-1,2-diol
-
far greater selectivity for trans-stilbene oxide versus cis-stilbene oxide. 0.06% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
cis-stilbene oxide + H2O
?
-
-
-
-
?
cis-stilbene oxide + H2O
?
cress
-
greater selectivity for trans-stilbene oxide versus cis-stilbene oxide
-
-
?
cis-stilbene oxide + H2O
?
-
-
-
-
?
cis-stilbene oxide + H2O
?
-
-
-
-
?
cis-stilbene oxide + H2O
?
-
-
-
-
?
cis-stilbene oxide + H2O
?
-
-
-
-
?
cis-stilbene oxide + H2O
?
-
-
-
-
?
cis-stilbene oxide + H2O
?
-
greater selectivity for trans-stilbene oxide versus cis-stilbene oxide
-
-
?
clofibrate + H2O
?
-
-
-
-
?
clofibrate + H2O
?
-
-
-
-
?
clofibrate + H2O
?
-
-
-
-
?
clofibrate + H2O
?
-
-
-
-
?
clofibrate + H2O
?
-
-
-
-
?
cyano(2-methoxy-naphthalen-6-yl)methyl trans-2-(3-propyloxiran-2-yl) acetate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
-
-
-
-
?
cyano(2-methoxy-naphthalen-6-yl)methyl trans-2-(3-propyloxiran-2-yl) acetate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
-
-
-
-
?
cyano(6-methoxy-2-naphthyl)methyl (3,3-dimethyloxiran-2-yl)methyl carbonate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
-
-
-
-
?
cyano(6-methoxy-2-naphthyl)methyl (3,3-dimethyloxiran-2-yl)methyl carbonate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
-
-
-
-
?
cyano(6-methoxy-2-naphthyl)methyl (3-ethyloxiran-2-yl)methyl carbonate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
-
-
-
-
?
cyano(6-methoxy-2-naphthyl)methyl (3-ethyloxiran-2-yl)methyl carbonate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
-
-
-
-
?
cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)acetate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
-
-
-
-
?
cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)acetate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
-
-
-
-
?
cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)methyl carbonate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
-
preferred fluorogenic substrate
-
-
?
cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)methyl carbonate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
-
-
-
-
?
cyano(6-methoxy-2-naphthyl)methyl (3-propyloxiran-2-yl)methyl carbonate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
-
-
-
-
?
cyano(6-methoxy-2-naphthyl)methyl (3-propyloxiran-2-yl)methyl carbonate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
-
-
-
-
?
cyano(6-methoxy-2-naphthyl)methyl [3-(4-nitrophenyl)oxiran-2-yl]methyl carbonate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
-
-
-
-
?
cyano(6-methoxy-2-naphthyl)methyl [3-(4-nitrophenyl)oxiran-2-yl]methyl carbonate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
-
-
-
-
?
cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate + H2O
?
-
i.e. CMNPC, a fluorescent substrate
-
-
?
cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate + H2O
?
i.e. CMNPC, a fluorescent substrate
-
-
?
cyano(6-methoxynaphthalen-2-yl)methyl (3-phenyloxiran-2-yl)acetate + H2O
[1,2-dihydroxy-2-(3-phenyloxiran-2-yl)ethoxy](6-methoxynaphthalen-2-yl)acetonitrile
-
-
-
-
?
cyano(6-methoxynaphthalen-2-yl)methyl (3-phenyloxiran-2-yl)acetate + H2O
[1,2-dihydroxy-2-(3-phenyloxiran-2-yl)ethoxy](6-methoxynaphthalen-2-yl)acetonitrile
-
-
-
-
?
cyano-(2-methoxynaphthalen-6-yl)-methyl trans-(3-phenyl-oxiran-2-yl)-methyl carbonate + H2O
?
-
-
-
?
cyano-(2-methoxynaphthalen-6-yl)-methyl trans-(3-phenyl-oxiran-2-yl)-methyl carbonate + H2O
?
CMNPC, a fluorescent substrate with an epoxide group, which releases a strong fluorophore 6-methoxy-2-naphthaldehyde after hydrolysis of the epoxide
-
-
?
cyclohexene oxide + H2O
?
-
-
-
-
?
cyclohexene oxide + H2O
?
-
-
-
-
?
cyclohexene oxide + H2O
?
-
-
-
-
?
di(2-ethylhexyl)phthalate + H2O
?
-
-
-
-
?
di(2-ethylhexyl)phthalate + H2O
?
-
-
-
-
?
di(2-ethylhexyl)phthalate + H2O
?
-
-
-
-
?
di(2-ethylhexyl)phthalate + H2O
?
-
-
-
-
?
di(2-ethylhexyl)phthalate + H2O
?
-
-
-
-
?
epoxy stearic acid + H2O
?
-
-
-
-
?
epoxy stearic acid + H2O
?
-
-
-
-
?
epoxyeicosatrienoic acid + H2O
dihydroxyeicosatrienoic acid
-
-
-
-
?
epoxyeicosatrienoic acid + H2O
dihydroxyeicosatrienoic acid
-
-
-
?
epoxyeicosatrienoic acid + H2O
dihydroxyeicosatrienoic acid
-
elimination of the biological effects of the substrate, involved in regulation of renal eicosanoid levels and blood pressure, mechanism
-
-
?
epoxyeicosatrienoic acid + H2O
dihydroxyeicosatrienoic acid
-
-
-
?
epoxyeicosatrienoic acid + H2O
dihydroxyeicosatrienoic acid
-
-
-
-
?
epoxyeicosatrienoic acid + H2O
dihydroxyeicosatrienoic acid
-
-
-
?
epoxyeicosatrienoic acid + H2O
dihydroxyeicosatrienoic acid
-
-
-
?
epoxyeicosatrienoic acid + H2O
dihydroxyeicosatrienoic acid
-
-
-
-
?
epoxyeicosatrienoic acid + H2O
dihydroxyeicosatrienoic acid
-
-
-
?
epoxyeicosatrienoic acid + H2O
dihydroxyeicosatrienoic acid
-
physiological function and regulation of the reaction, overview
-
-
?
epoxyeicosatrienoic acid + H2O
dihydroxyeicosatrienoic acid
-
-
-
?
hepoxilin A3 + H2O
?
-
excellent substrate for sEH
-
-
?
hepoxilin A3 + H2O
?
excellent substrate for sEH
-
-
?
hepoxilin B3 + H2O
?
-
excellent substrate for sEH
-
-
?
hepoxilin B3 + H2O
?
excellent substrate for sEH
-
-
?
juvenile hormone III + H2O
?
-
11.9% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
juvenile hormone III + H2O
?
-
6.3% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
juvenile hormone III + H2O
?
-
6.3% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
juvenile hormone III + H2O
?
-
3.5% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
juvenile hormone III + H2O
?
-
7.1% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
leukotoxin + H2O
leukotoxin diol
-
-
-
-
?
leukotoxin + H2O
leukotoxin diol
-
-
-
?
leukotriene A4 + H2O
?
-
-
-
-
?
leukotriene A4 + H2O
?
-
-
-
-
?
naphthalene 1,2-oxide + H2O
?
-
-
-
-
?
naphthalene 1,2-oxide + H2O
?
-
-
-
-
?
phenanthrene-9,10-oxide + H2O
?
-
-
-
-
?
phenanthrene-9,10-oxide + H2O
?
-
-
-
-
?
phenanthrene-9,10-oxide + H2O
?
-
-
-
-
?
phenanthrene-9,10-oxide + H2O
?
-
-
-
-
?
phenanthrene-9,10-oxide + H2O
?
-
-
-
-
?
phenobarbital + H2O
?
-
-
-
-
?
phenobarbital + H2O
?
-
-
-
-
?
phenobarbital + H2O
?
-
-
-
-
?
phenobarbital + H2O
?
-
-
-
-
?
phenobarbital + H2O
?
-
-
-
-
?
rac trans-1,3-diphenylpropene oxide + H2O
?
-
-
-
-
?
rac trans-1,3-diphenylpropene oxide + H2O
?
-
-
-
?
racemic 4-nitrophenyl-trans-2,3-epoxy-3-phenylpropyl carbonate + H2O
?
-
-
-
-
?
racemic 4-nitrophenyl-trans-2,3-epoxy-3-phenylpropyl carbonate + H2O
?
-
-
-
-
?
racemic ethyl 3-phenylglycidate + H2O
?
-
production of (2R,3S)-ethyl 3-phenylglycidate with 95% enantiomeric excess and 26% yield in 12 h from 0.2% (w/v) of the racemat
-
-
?
racemic ethyl 3-phenylglycidate + H2O
?
-
production of (2R,3S)-ethyl 3-phenylglycidate with 95% enantiomeric excess and 26% yield in 12 h from 0.2% (w/v) of the racemat
-
-
?
styrene 7,8-oxide + H2O
?
-
-
-
-
?
styrene 7,8-oxide + H2O
?
-
-
-
-
?
styrene 7,8-oxide + H2O
styrene glycol
-
-
-
-
?
styrene 7,8-oxide + H2O
styrene glycol
-
-
-
-
?
styrene oxide + H2O
?
-
-
-
?
styrene oxide + H2O
?
-
-
-
-
?
styrene oxide + H2O
?
-
very poor substrate for sEH
-
-
?
styrene oxide + H2O
?
-
-
-
-
?
styrene oxide + H2O
?
-
-
-
-
?
styrene oxide + H2O
?
-
-
-
-
?
styrene oxide + H2O
?
-
-
-
-
?
styrene oxide + H2O
styrene glycol
-
-
-
-
?
styrene oxide + H2O
styrene glycol
-
-
-
-
?
styrene oxide + H2O
styrene glycol
-
-
-
-
?
styrene oxide + H2O
styrene glycol
-
-
-
-
?
styrene oxide + H2O
styrene glycol
-
-
-
?
styrene oxide + H2O
styrene glycol
-
-
-
-
?
styrene oxide + H2O
styrene glycol
-
-
-
-
?
trans-1,3-diphenylpropene oxide + H2O
1,3-diphenylpropane-1,2-diol
-
-
-
-
?
trans-1,3-diphenylpropene oxide + H2O
1,3-diphenylpropane-1,2-diol
-
-
-
-
?
trans-1,3-diphenylpropene oxide + H2O
1,3-diphenylpropane-1,2-diol
-
little to no selectivity for cis-isomer or trans-isomer
-
-
?
trans-1,3-diphenylpropene oxide + H2O
1,3-diphenylpropane-1,2-diol
tritium labeled for radiometric assay
-
-
?
trans-1,3-diphenylpropene oxide + H2O
?
cress
-
-
-
-
?
trans-1,3-diphenylpropene oxide + H2O
?
the His-tag of the recombinant enzyme probably interfers with the enzyme activity
-
-
?
trans-1,3-diphenylpropene oxide + H2O
?
-
-
-
?
trans-1,3-diphenylpropene oxide + H2O
?
-
-
-
-
?
trans-1,3-diphenylpropene oxide + H2O
?
-
-
-
-
?
trans-1,3-diphenylpropene oxide + H2O
?
-
-
-
-
?
trans-2-methylstyrene oxide + H2O
?
-
-
-
-
?
trans-2-methylstyrene oxide + H2O
?
-
-
-
-
?
trans-8-ethylstyrene 7,8-oxide + H2O
?
-
i.e. TESO
-
-
?
trans-8-ethylstyrene 7,8-oxide + H2O
?
-
i.e. TESO
-
-
?
trans-9,10-epoxystearate + H2O
?
-
-
-
?
trans-9,10-epoxystearate + H2O
?
-
-
-
-
?
trans-9,10-epoxystearate + H2O
?
-
-
-
-
?
trans-9,10-epoxystearate + H2O
?
-
-
-
-
?
trans-9,10-epoxystearate + H2O
?
-
-
-
-
?
trans-9,10-epoxystearate + H2O
?
-
-
-
-
?
trans-beta-methyl-styrene oxide + H2O
?
-
-
-
-
?
trans-beta-methyl-styrene oxide + H2O
?
-
-
-
-
?
trans-beta-methyl-styrene oxide + H2O
?
-
-
-
-
?
trans-diphenyl-propene oxide + H2O
trans-diphenyl-propene diol
-
-
-
?
trans-diphenyl-propene oxide + H2O
trans-diphenyl-propene diol
-
-
-
?
trans-diphenyl-propene oxide + H2O
trans-diphenyl-propene diol
-
-
-
?
trans-diphenylpropene oxide + H2O
?
-
-
-
-
?
trans-diphenylpropene oxide + H2O
?
-
-
-
-
?
trans-diphenylpropene oxide + H2O
?
-
-
-
?
trans-diphenylpropene oxide + H2O
?
-
recombinant enzyme
-
-
?
trans-diphenylpropene oxide + H2O
?
-
-
-
-
?
trans-diphenylpropene oxide + H2O
?
-
recombinant enzyme
-
-
?
trans-ethyl styrene oxide + H2O
?
-
-
-
-
?
trans-ethyl styrene oxide + H2O
?
-
-
-
-
?
trans-ethyl styrene oxide + H2O
?
-
-
-
-
?
trans-ethyl styrene oxide + H2O
?
-
-
-
-
?
trans-ethyl styrene oxide + H2O
?
-
-
-
-
?
trans-ethyl styrene oxide + H2O
?
-
-
-
-
?
trans-ethyl styrene oxide + H2O
?
-
trans-beta-ethyl styrene oxide
-
-
?
trans-stilbene oxide + H2O
1,2-diphenylethane-1,2-diol
-
-
-
-
?
trans-stilbene oxide + H2O
1,2-diphenylethane-1,2-diol
-
far greater selectivity for trans-stilbene oxide versus cis-stilbene oxide. 84% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
trans-stilbene oxide + H2O
1,2-diphenylethane-1,2-diol
-
-
-
-
?
trans-stilbene oxide + H2O
1,2-diphenylethane-1,2-diol
-
2.8% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
trans-stilbene oxide + H2O
1,2-diphenylethane-1,2-diol
-
highly selective for the trans-enantiomer. 1% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
trans-stilbene oxide + H2O
1,2-diphenylethane-1,2-diol
-
-
-
-
?
trans-stilbene oxide + H2O
1,2-diphenylethane-1,2-diol
-
far greater selectivity for trans-stilbene oxide versus cis-stilbene oxide. 5.6% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
trans-stilbene oxide + H2O
?
-
-
-
-
?
trans-stilbene oxide + H2O
?
cress
-
greater selectivity for trans-stilbene oxide versus cis-stilbene oxide
-
-
?
trans-stilbene oxide + H2O
?
-
-
-
-
?
trans-stilbene oxide + H2O
?
-
highly selective for the trans-enantiomer. 1.2% of the activity with 2,3-epoxy-1,3-diphenyl-propane
-
-
?
trans-stilbene oxide + H2O
?
-
-
-
-
?
trans-stilbene oxide + H2O
?
-
-
-
-
?
trans-stilbene oxide + H2O
?
-
-
-
?
trans-stilbene oxide + H2O
?
-
-
-
-
?
trans-stilbene oxide + H2O
?
-
-
-
-
?
trans-stilbene oxide + H2O
?
-
greater selectivity for trans-stilbene oxide versus cis-stilbene oxide
-
-
?
[3-(4-chlorophenyl)oxiran-2-yl]methyl cyano(6-methoxy-2-naphthyl)methyl carbonate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
-
-
-
-
?
[3-(4-chlorophenyl)oxiran-2-yl]methyl cyano(6-methoxy-2-naphthyl)methyl carbonate + H2O
6-methoxy-2-naphthaldehyde + CN- + ?
-
-
-
-
?
additional information
?
-
-
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
-
-
?
additional information
?
-
-
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
-
-
?
additional information
?
-
-
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
-
-
?
additional information
?
-
-
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
-
-
?
additional information
?
-
-
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
-
-
?
additional information
?
-
-
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
-
-
?
additional information
?
-
-
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
-
-
?
additional information
?
-
-
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
-
-
?
additional information
?
-
-
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
-
-
?
additional information
?
-
-
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
-
-
?
additional information
?
-
-
the enzyme is involved in host-defense and cutin biosynthesis, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
-
-
?
additional information
?
-
-
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
-
-
?
additional information
?
-
degradation kinetics of styrene oxide, overview. At 10°C, the enantiopurity of (R)-styrene oxide reaches 99% with 34.8% yield and 80 min reaction time. On the contrary, a 20.5% yield is obtained at 40°C. At 50°C, the enantiopurity more than 98% cannot be obtained for 30 min-reaction. As a conclusion, the yield increased 1.7fold at 10°C, compared to 30°C
-
-
?
additional information
?
-
-
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
-
-
?
additional information
?
-
-
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
-
-
?
additional information
?
-
-
plays an important role during germination of seeds
-
-
?
additional information
?
-
-
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
-
-
?
additional information
?
-
-
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
-
-
?
additional information
?
-
-
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
-
-
?
additional information
?
-
the soluble-type epoxide hydrolase may play a crucial role in the self-defense system of the plant
-
-
?
additional information
?
-
-
the soluble-type epoxide hydrolase may play a crucial role in the self-defense system of the plant
-
-
?
additional information
?
-
-
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
microsomal enzyme shows highest activity with trans-2-methylstyrane oxide, followed by styrene 7,8-oxide, cis-2-methylstyrene oxide, cis-1,2-dimethylstyrene oxide, trans-1,2-dimethylstyrene oxide and 2,2-dimethylstyrene oxide. With the cytosolic enzyme the same order is obtained for the first three substrates, whereas activity with 2,2-dimethylstyrene oxide is higher than with cis-1,2-dimethylstyrene oxide and no hydration occurs with trans-1,2-dimethylstyrene oxide
-
-
?
additional information
?
-
-
the N-terminal domain of the enzyme is a functional phosphatase unaffected by a number of classic phosphatase inhibitors. The phosphatase domain has high specificity for lipophilic phosphates
-
-
?
additional information
?
-
-
enzyme regulation, overview
-
-
?
additional information
?
-
-
the enzyme is involved in regulation of blood pressure and inflammation
-
-
?
additional information
?
-
-
reaction mechanism with flurogenic substrates
-
-
?
additional information
?
-
-
substrate specificity, 2 enzymes with different specificities termed cytosolic TESO hydrolase and cytosolic PNSO hydrolase, no activity with benz[a]pyrene 4,5-oxide
-
-
?
additional information
?
-
-
substrate specificity, the microsomal enzyme rapidly hydrolyzes epoxides on cyclic systems as well as mono, 1,1-di and cis-1,2-disubstituted epoxides
-
-
?
additional information
?
-
-
the enzyme also shows phosphatase activity, EC 3.1.3.76, sEH prefers gem-di-, trans-di-, cis-di-, tri-, and tetra-substituted epoxides
-
-
?
additional information
?
-
-
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates, overview
-
-
?
additional information
?
-
-
differential localization of the enzyme in the brain indicates an essential role in the central nervous system
-
-
?
additional information
?
-
-
kinetic analysis of the effects of human enzyme polymorphisms on the N-terminal phosphatase activity of soluble epoxide hydrolase activity
-
-
?
additional information
?
-
activity of the sEH can be regulated by the tyrosine nitration of the protein
-
-
?
additional information
?
-
-
activity of the sEH can be regulated by the tyrosine nitration of the protein
-
-
?
additional information
?
-
contribution of hydrolase and phosphatase domains in soluble epoxide hydrolase to vascular endothelial growth factor expression and cell growth, overview
-
-
?
additional information
?
-
-
contribution of hydrolase and phosphatase domains in soluble epoxide hydrolase to vascular endothelial growth factor expression and cell growth, overview
-
-
?
additional information
?
-
EETs are important regulators of cardiovascular function, of cerebral blood flow, and exhibit a wide array of potentially beneficial actions in stroke, including vasodilation, neuroprotection, promotion of angiogenesis and suppression of platelet aggregation, oxidative stress and postischemic inflammation, detailed overview
-
-
?
additional information
?
-
-
epoxyeicosatrienoic acids are substrates of sEH, enzyme regulation, overview
-
-
?
additional information
?
-
sEH rapidly hydrolyzes eicosatrienoic acids to their corresponding dihydroxyeicosatrienoic acid, DHET, metabolites, which, in general, are much less biologically active than eicosatrienoic acids. Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation, overview. functional impact of CYP epoxygenase-derived eicosatrienoic acids biosynthesis and sEH-mediated xyeicosatrienoic acids hydrolysis on key inflammatory process in the cardiovascular system
-
-
?
additional information
?
-
-
soluble epoxide hydrolase is an enzyme that catalyzes the hydrolysis of epoxyeicosatrienoic acids, EETs, which are lipid mediators derived from arachidonic acid through the cytochrome P450 epoxygenase pathway. EETs can activate multiple antiapoptotic targets through PI3K/Akt survival signaling and protect cardiomyocytes from hypoxia/anoxia
-
-
?
additional information
?
-
Vascular actions and antiinflammatory actions of epoxyeicosatrienoic acids, overview
-
-
?
additional information
?
-
development of a high throughput cell-based assay for soluble epoxide hydrolase using BacMam technology, determination of Cy3B-fluorescence labeled product Cy3B-DAE-14,15-DHET, i.e. 14-(2-[(2-([(5Z,8Z,11Z)-14,15-dihydroxy-5,8,11-icosatrienoyl]amino)ethyl)amino]-2-oxoethyl)-16,16,18,18-tetramethyl-6,7,7a,8a,9,10,16,18-octahydrobenzo[2'',3''] indolizino[8'',7'':5',6']pyrano[3',2':3,4]pyrido[1,2-a]indol-5-ium-2-sulfonate, overview
-
-
?
additional information
?
-
-
each monomer is comprised of two distinct structural domains, linked by a proline-rich segment, the 35 kDa C-terminal domain displays epoxide hydrolase activity, while the N-terminal domain exhibits phosphatase activity
-
-
?
additional information
?
-
sEH has phosphatase activity as well as epoxide hydrolase activity
-
-
?
additional information
?
-
-
sEH has phosphatase activity as well as epoxide hydrolase activity
-
-
?
additional information
?
-
the C-terminal domain of the soluble epoxide hydrolase metabolizes epoxyeicosatrienoic acids, EETs, to their less active diols, while the N-terminal domain demonstrates lipid phosphatase activity
-
-
?
additional information
?
-
-
the C-terminal domain of the soluble epoxide hydrolase metabolizes epoxyeicosatrienoic acids, EETs, to their less active diols, while the N-terminal domain demonstrates lipid phosphatase activity
-
-
?
additional information
?
-
the enzyme converts epoxyalcohols into linoleate triols
-
-
?
additional information
?
-
the enzyme converts epoxyalcohols into linoleate triols
-
-
?
additional information
?
-
-
the enzyme converts epoxyalcohols into linoleate triols
-
-
?
additional information
?
-
human soluble EH (sEH or EPHX2) and human or murine epoxide hydrolase-3 (EH3 or EPHX3) hydrolyze cis or trans allylic epoxides to single diastereomers, identical to the major isomers detected in epidermis. Microsomal EH (mEH or EPHX1, EC 3.3.2.9) is inactive with these substrates. 12,13-trans-Epoxy-octadeca-9E-enoic acid is completely hydrolyzed by human sEH, human EH3, and N-truncated murine EH3 and mostly hydrolyzed using the N-truncated+7aa-insert murine EH3. 12,13-cis-Epoxy-octadeca-9E-enoic acid is hardly hydrolyzed by human EH3, N-truncated murine EH3, and the N-truncated+7aa-insert murine EH3, and 30% hydrolysis is observed using human sEH. At low substrate concentrations, EPHX2 hydrolyzes 14,15-epoxyeicosatrienoic acid (EET) at twice the rate of the epidermal epoxyalcohol, 9R,10R-trans-epoxy-11E-13R-hydroxy-octadecenoic acid, whereas human or murine EPHX3 hydrolyze the allylic epoxyalcohol at 31fold and 39fold higher rates, respectively
-
-
?
additional information
?
-
human soluble EH (sEH or EPHX2) and human or murine epoxide hydrolase-3 (EH3 or EPHX3) hydrolyze cis or trans allylic epoxides to single diastereomers, identical to the major isomers detected in epidermis. Microsomal EH (mEH or EPHX1, EC 3.3.2.9) is inactive with these substrates. 12,13-trans-Epoxy-octadeca-9E-enoic acid is completely hydrolyzed by human sEH, human EH3, and N-truncated murine EH3 and mostly hydrolyzed using the N-truncated+7aa-insert murine EH3. 12,13-cis-Epoxy-octadeca-9E-enoic acid is hardly hydrolyzed by human EH3, N-truncated murine EH3, and the N-truncated+7aa-insert murine EH3, and 30% hydrolysis is observed using human sEH. At low substrate concentrations, EPHX2 hydrolyzes 14,15-epoxyeicosatrienoic acid (EET) at twice the rate of the epidermal epoxyalcohol, 9R,10R-trans-epoxy-11E-13R-hydroxy-octadecenoic acid, whereas human or murine EPHX3 hydrolyze the allylic epoxyalcohol at 31fold and 39fold higher rates, respectively
-
-
?
additional information
?
-
-
human soluble EH (sEH or EPHX2) and human or murine epoxide hydrolase-3 (EH3 or EPHX3) hydrolyze cis or trans allylic epoxides to single diastereomers, identical to the major isomers detected in epidermis. Microsomal EH (mEH or EPHX1, EC 3.3.2.9) is inactive with these substrates. 12,13-trans-Epoxy-octadeca-9E-enoic acid is completely hydrolyzed by human sEH, human EH3, and N-truncated murine EH3 and mostly hydrolyzed using the N-truncated+7aa-insert murine EH3. 12,13-cis-Epoxy-octadeca-9E-enoic acid is hardly hydrolyzed by human EH3, N-truncated murine EH3, and the N-truncated+7aa-insert murine EH3, and 30% hydrolysis is observed using human sEH. At low substrate concentrations, EPHX2 hydrolyzes 14,15-epoxyeicosatrienoic acid (EET) at twice the rate of the epidermal epoxyalcohol, 9R,10R-trans-epoxy-11E-13R-hydroxy-octadecenoic acid, whereas human or murine EPHX3 hydrolyze the allylic epoxyalcohol at 31fold and 39fold higher rates, respectively
-
-
?
additional information
?
-
-
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
-
-
?
additional information
?
-
-
substrate specificity, the microsomal enzyme rapidly hydrolyzes epoxides on cyclic systems as well as mono, 1,1-di and cis-1,2-disubstituted epoxides
-
-
?
additional information
?
-
-
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
-
-
?
additional information
?
-
-
synthesis of anti-fungal substances in fruits, the enzyme is involved in host-defense and cutin biosynthesis, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
-
-
?
additional information
?
-
-
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
-
-
?
additional information
?
-
-
the enzyme possesses an epoxide hydrolyzing as well as a lipid phosphatase activity. Favored sEH substrates are trans-substituted over cis-substituted epoxides
-
-
?
additional information
?
-
-
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
-
-
?
additional information
?
-
-
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
-
-
?
additional information
?
-
-
involvement of the Asp333-His523 pair in the catalytic mechanism
-
-
?
additional information
?
-
-
induced by parental exposure to N-ethyl-N-nitrosourea
-
-
?
additional information
?
-
-
inducers
-
-
?
additional information
?
-
-
oxygenated lipids may be endogenous substrates for the cytosolic epoxide hydrolase
-
-
?
additional information
?
-
-
enzyme inhibition decreases plasma levels of proinflammatory cytokines and nitric oxide metabolites while promoting the formation of lipoxins, thus supporting inflammatory resolution
-
-
?
additional information
?
-
-
the enzyme is involved in regulation of blood pressure and inflammation
-
-
?
additional information
?
-
the enzyme is involved in synthesis of tetrahydrofuran diol and trihydroxy furanyl lipids, enzyme regulation, overview
-
-
?
additional information
?
-
-
reaction mechanism with flurogenic substrates
-
-
?
additional information
?
-
-
sEH prefers gem-di-, trans-di-, cis-di-, tri-, and tetra-substituted epoxides
-
-
?
additional information
?
-
substrate specificity, the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates, except for the isozyme EPXH2B, overview
-
-
?
additional information
?
-
-
substrate specificity, the microsomal enzyme rapidly hydrolyzes epoxides on cyclic systems as well as mono, 1,1-di and cis-1,2-disubstituted epoxides
-
-
?
additional information
?
-
activity of the sEH can be regulated by the tyrosine nitration of the protein
-
-
?
additional information
?
-
-
activity of the sEH can be regulated by the tyrosine nitration of the protein
-
-
?
additional information
?
-
EETs are important regulators of cardiovascular function, of cerebral blood flow, and exhibit a wide array of potentially beneficial actions in stroke, including vasodilation, neuroprotection, promotion of angiogenesis and suppression of platelet aggregation, oxidative stress and postischemic inflammation, detailed overview
-
-
?
additional information
?
-
epoxyeicosatrienoic acids are substrates of sEH, enzyme regulation, overview
-
-
?
additional information
?
-
sEH catalyzes the conversion of epoxyeicosatrienoic acids, EETs, to form the corresponding dihydroxyeicosatrienoic acids, DHETs
-
-
?
additional information
?
-
-
sEH catalyzes the conversion of epoxyeicosatrienoic acids, EETs, to form the corresponding dihydroxyeicosatrienoic acids, DHETs
-
-
?
additional information
?
-
sEH rapidly hydrolyzes eicosatrienoic acids to their corresponding dihydroxyeicosatrienoic acid, DHET, metabolites, which, in general, are much less biologically active than eicosatrienoic acids. Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation, overview. functional impact of CYP epoxygenase-derived eicosatrienoic acids biosynthesis and sEH-mediated xyeicosatrienoic acids hydrolysis on key inflammatory process in the cardiovascular system
-
-
?
additional information
?
-
soluble epoxide hydrolase is an enzyme that catalyzes the hydrolysis of epoxyeicosatrienoic acids, EETs, which are lipid mediators derived from arachidonic acid through the cytochrome P450 epoxygenase pathway. EETs can activate multiple antiapoptotic targets through PI3K/Akt survival signaling and protect cardiomyocytes from hypoxia/anoxia
-
-
?
additional information
?
-
each monomer is comprised of two distinct structural domains, linked by a proline-rich segment, the 35 kDa C-terminal domain displays epoxide hydrolase activity, while the N-terminal domain exhibits phosphatase activity
-
-
?
additional information
?
-
sEH is bifunctional enzyme with C-terminal hydrolase and N-terminal phosphatase activities
-
-
?
additional information
?
-
-
sEH is bifunctional enzyme with C-terminal hydrolase and N-terminal phosphatase activities
-
-
?
additional information
?
-
the C-terminal domain of the soluble epoxide hydrolase metabolizes epoxyeicosatrienoic acids, EETs, to their less active diols, while the N-terminal domain demonstrates lipid phosphatase activity
-
-
?
additional information
?
-
the enzyme has a broad substrate range and shows high regio- and enantioselectivity for nucleophilic ring opening by Asp333
-
-
?
additional information
?
-
the enzyme converts epoxyalcohols into linoleate triols
-
-
?
additional information
?
-
-
the enzyme converts epoxyalcohols into linoleate triols
-
-
?
additional information
?
-
human soluble EH (sEH or EPHX2) and human or murine epoxide hydrolase-3 (EH3 or EPHX3) hydrolyze cis or trans allylic epoxides to single diastereomers, identical to the major isomers detected in epidermis. Microsomal EH (mEH or EPHX1, EC 3.3.2.9) is inactive with these substrates. 12,13-trans-Epoxy-octadeca-9E-enoic acid is completely hydrolyzed by human sEH, human EH3, and N-truncated murine EH3 and mostly hydrolyzed using the N-truncated+7aa-insert murine EH3. 12,13-cis-Epoxy-octadeca-9E-enoic acid is hardly hydrolyzed by human EH3, N-truncated murine EH3, and the N-truncated+7aa-insert murine EH3, and 30% hydrolysis is observed using human sEH. At low substrate concentrations, EPHX2 hydrolyzes 14,15-epoxyeicosatrienoic acid (EET) at twice the rate of the epidermal epoxyalcohol, 9R,10R-trans-epoxy-11E-13R-hydroxy-octadecenoic acid, whereas human or murine EPHX3 hydrolyze the allylic epoxyalcohol at 31fold and 39fold higher rates, respectively
-
-
?
additional information
?
-
-
human soluble EH (sEH or EPHX2) and human or murine epoxide hydrolase-3 (EH3 or EPHX3) hydrolyze cis or trans allylic epoxides to single diastereomers, identical to the major isomers detected in epidermis. Microsomal EH (mEH or EPHX1, EC 3.3.2.9) is inactive with these substrates. 12,13-trans-Epoxy-octadeca-9E-enoic acid is completely hydrolyzed by human sEH, human EH3, and N-truncated murine EH3 and mostly hydrolyzed using the N-truncated+7aa-insert murine EH3. 12,13-cis-Epoxy-octadeca-9E-enoic acid is hardly hydrolyzed by human EH3, N-truncated murine EH3, and the N-truncated+7aa-insert murine EH3, and 30% hydrolysis is observed using human sEH. At low substrate concentrations, EPHX2 hydrolyzes 14,15-epoxyeicosatrienoic acid (EET) at twice the rate of the epidermal epoxyalcohol, 9R,10R-trans-epoxy-11E-13R-hydroxy-octadecenoic acid, whereas human or murine EPHX3 hydrolyze the allylic epoxyalcohol at 31fold and 39fold higher rates, respectively
-
-
?
additional information
?
-
the sEH is a dual function enzyme that generates dihydroxy-fatty acids via its C-terminal hydrolase domain, while the N-terminal phosphatase domain has been proposed to have lipid phosphatase activity, bifunctional epoxide hydrolase 2 includes cytosolic epoxide hydrolase 2, sEH, EC 3.3.2.10, and lipid-phosphate phosphatase, EC 3.1.3.76
-
-
?
additional information
?
-
the sEH is a dual function enzyme that generates dihydroxy-fatty acids via its C-terminal hydrolase domain, while the N-terminal phosphatase domain has been proposed to have lipid phosphatase activity, bifunctional epoxide hydrolase 2 includes cytosolic epoxide hydrolase 2, sEH, EC 3.3.2.10, and lipid-phosphate phosphatase, EC 3.1.3.76
-
-
?
additional information
?
-
the C-terminal domain of the soluble epoxide hydrolase metabolizes epoxyeicosatrienoic acids, EETs, to their less active diols, while the N-terminal domain demonstrates lipid phosphatase activity
-
-
?
additional information
?
-
activity of the sEH can be regulated by the tyrosine nitration of the protein
-
-
?
additional information
?
-
-
induced by parental exposure to N-ethyl-N-nitrosourea
-
-
?
additional information
?
-
-
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
-
-
?
additional information
?
-
-
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
-
-
?
additional information
?
-
-
enzyme regulation, overview
-
-
?
additional information
?
-
-
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
-
-
?
additional information
?
-
-
substrate specificity, the microsomal enzyme rapidly hydrolyzes epoxides on cyclic systems as well as mono, 1,1-di and cis-1,2-disubstituted epoxides
-
-
?
additional information
?
-
-
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
-
-
?
additional information
?
-
-
stereoselective hydrolysis of epoxyeicosatrienoic acids (EETs) by sEH
-
-
?
additional information
?
-
-
stereoselective hydrolysis of epoxides by enzyme sEH, overview
-
-
?
additional information
?
-
-
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
-
-
?
additional information
?
-
-
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
-
-
?
additional information
?
-
-
enzyme regulation, overview
-
-
?
additional information
?
-
-
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lipid/carbohydrate metabolism, enzyme regulation, overview
-
-
?
additional information
?
-
-
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
-
-
?
additional information
?
-
-
enzyme regulation, overview
-
-
?
additional information
?
-
-
Asp333, Asp495 and His523 form the catalytic triad
-
-
?
additional information
?
-
-
induced by xenobiotics
-
-
?
additional information
?
-
-
enzyme inhibition in vivo leads to increased blood pressure and heart rate due to an increase in epoxyeicosatrienoic acid-mediated generation of reactive oxygen species
-
-
?
additional information
?
-
-
the activity for epoxyeicosatrienoic acids is elevated 5 to 54fold in renal cortical S9 fraction from the spontaneously hypertensive rats compared to normotensive Wistar-Kyoto rats, the enzyme is involved in regulation of blood pressure
-
-
?
additional information
?
-
-
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
-
-
?
additional information
?
-
-
the enzyme is involved in regulation of blood pressure and inflammation
-
-
?
additional information
?
-
-
the enzyme is involved in the arachidonic acid metabolic pathway
-
-
?
additional information
?
-
-
enantioselectivity with fatty acid epoxide substrates
-
-
?
additional information
?
-
-
sEH prefers gem-di-, trans-di-, cis-di-, tri-, and tetra-substituted epoxides
-
-
?
additional information
?
-
-
substrate specificity, no activity with benz[a]pyrene 4,5-oxide
-
-
?
additional information
?
-
-
substrate specificity, the microsomal enzyme rapidly hydrolyzes epoxides on cyclic systems as well as mono, 1,1-di and cis-1,2-disubstituted epoxides
-
-
?
additional information
?
-
-
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates, overview
-
-
?
additional information
?
-
SEH converts cardiovascular protective epoxyeicosatrienoic acids into less active diols attenuating the protective properties, overview
-
-
?
additional information
?
-
-
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
-
-
?
additional information
?
-
-
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
-
-
?
additional information
?
-
-
the enzyme is involved in host-defense and cutin biosynthesis, synthesis of (9S,10S,11R)-trihydroxy-12(Z)-octadecenoic and (9S,12S,13S)-trihydroxy-10(E)-octadecenoic acids with potent anti-fungal properties, preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
-
-
?
additional information
?
-
-
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
-
-
?
additional information
?
-
-
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
-
-
?
additional information
?
-
-
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
-
-
?
additional information
?
-
-
enzyme regulation, overview
-
-
?
additional information
?
-
-
the enzyme is involved in metabolism of epoxide lipids in blood pressure, inflammation, reproduction and in lidpi/carbohydrate metabolism, enzyme regulation, overview
-
-
?
additional information
?
-
-
the enzyme prefers trans- over cis-epoxides of sterically hindered substrates like stilbene oxides, the C-terminal domain catalyzes epoxy fatty acid hydrolysis, the N-terminal catalytic domain has also phosphatase activity with specificity for fatty acid diol phosphates
-
-
?
additional information
?
-
-
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
-
-
?
additional information
?
-
-
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
-
-
?
additional information
?
-
-
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
-
-
?
additional information
?
-
-
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
-
-
?
additional information
?
-
-
the enzyme does not show phosphatase activity toward 4-methylumbelliferyl phosphate or several lysophosphatidic acids
-
-
?
additional information
?
-
-
preferred endogenous substrates are epoxides containing fatty acids, e.g. epoxides of stearic and linoleic acids, and hepoxilins
-
-
?
additional information
?
-
-
plant enzymes prefer trans- over cis-epoxides of sterically hindered substrates like stilbene oxides
-
-
?
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(1R,2R)-1,2-epoxy-1-phenyl-1-propane
-
weak inhibition, IC50 is 1.1 mM
(1R,2R,4R,5S,6R,7S)-4-[(benzyloxy)methyl]-3,8-dioxatricyclo[5.1.0.02,4]octane-5,6-diyl diacetate
5.87% inhibition
(1R,3S)-N-(4-cyano-2-(trifluoromethyl)benzyl)-3-((4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)amino)cyclohexanecarboxamide
GSK2256294
(1S,2S)-1,2-epoxy-1-phenyl-1-propane
-
weak inhibition, IC50 is 2.4 mM, preincubation of enzyme with inhibitor does not influence the inhibitory effect
(1S,3R)-N-[[4-cyano-2-(trifluoromethyl)phenyl]methyl]-3-[[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]amino]cyclohexane-1-carboxamide
GSK2256294
(1S,6S,9R)-1-(4-hydroxy-3-methoxyphenyl)-6-methoxy-9-methyl-4-(prop-2-en-1-yl)-7-oxabicyclo[4.2.1]non-4-ene-3,8-dione
75.56% inhibition
(1Z)-1-[(4aS,8aR)-2-(3-[[(2S)-2-(5-methylfuran-2-yl)-2-(pyrrolidin-1-yl)ethyl]carbamoyl]phenyl)-4-oxooctahydrophthalazin-1(2H)-ylidene]dioxidan-1-ium
-
(2E)-4-[(2-methylpropyl)amino]-4-oxobut-2-enoic acid
25.86% inhibition
(2E)-5-(2H-1,3-benzodioxol-5-yl)-N-(2-methylpropyl)pent-2-enamide
93.12% inhibition, uncompetitive inhibition
(2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-N-(2-methylpropyl)penta-2,4-dienamide
86.54% inhibition, uncompetitive inhibition
(2E,4E)-N-(2-methylpropyl)deca-2,4-dienamide
52.12% inhibition
(2E,6E)-7-(2H-1,3-benzodioxol-5-yl)-N-(2-methylpropyl)hepta-2,6-dienamide
88.58% inhibition, uncompetitive inhibition
(2R,3R)-1-acetoxy-2,3-epoxy-3-(4-nitrophenyl)propane
-
IC50 is 0.069 mM
(2R,3R)-1-benzyloxy-2,3-epoxy-3-(4-nitrophenyl)propane
-
IC50 is 0.024 mM
(2R,3R)-1-ethoxy-2,3-epoxy-3-(4-nitrophenyl)propane
-
IC50 is 0.069 mM
(2R,3R)-2,3-epoxy-3-(4-nitrophenyl)glycidol
-
IC50 is 1.2 mM, the S-enantiomer is a 750fold better inhibitor compared to the R-isomer
(2R,3R)-2-(2,6-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-1-benzopyran-4-one
15.47% inhibition
(2R,3R)-3-(4-bromophenyl)glycidol
-
preincubation of enzyme with inhibitor increases the inhibitory effect
(2R,3R)-3-(4-nitrophenyl)glycidol
-
-
(2R,3R,3aS)-2-(4-hydroperoxy-3-methoxyphenyl)-3a-methoxy-3-methyl-5-(prop-2-en-1-yl)-3,3a-dihydro-1-benzofuran-6(2H)-one
86.57% inhibition
(2R,3R,4S,5S)-2,5-bis(3,4-dimethoxyphenyl)-3,4-dimethyloxolane
15.21% inhibition
(2R,3S,4S,5S)-2,5-bis(3,4-dimethoxyphenyl)-3,4-dimethyloxolane
7.12% inhibition
(2S)-5,7-dihydroxy-6-methoxy-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one
68.98% inhibition
(2S,3R,3aR)-2-(4-hydroperoxy-3-methoxyphenyl)-3a-methoxy-3-methyl-5-(prop-2-en-1-yl)-3,3a-dihydro-1-benzofuran-6(2H)-one
76.89% inhibition
(2S,3S)-1-acetoxy-2,3-epoxy-3-(4-nitrophenyl)propane
-
IC50 is 0.012 mM, preincubation of enzyme with inhibitor decreases the inhibitory effect
(2S,3S)-1-benzyloxy-2,3-epoxy-3-(4-nitrophenyl)propane
-
IC50 is 0.039 mM
(2S,3S)-1-ethoxy-2,3-epoxy-3-(4-nitrophenyl)propane
-
IC50 is 0.012 mM, preincubation of enzyme with inhibitor decreases the inhibitory effect
(2S,3S)-2,3-epoxy-3-(4-nitrophenyl)glycidol
-
IC50 is 0.0016 mM, the S-enantiomer is a 750fold better inhibitor compared to the R-isomer
(2S,3S)-3-(4-bromophenyl)glycidol
-
-
(2S,3S)-3-(4-nitrophenyl)glycidol
-
preincubation of enzyme with inhibitor increases the inhibitory effect
(3-[4-(allyloxy)phenyl]oxiran-2-yl)(phenyl)methanone
(3-[4-(benzyloxy)phenyl]oxiran-2-yl)(phenyl)methanone
(3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(4-fluorobenzene-1-sulfonyl)amino]piperidine-1-carboxamide
(3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(methanesulfonyl)amino]piperidine-1-carboxamide
(4-bromo-3-cyclopropyl-1H-pyrazol-1-yl)acetic acid
-
(4-bromophenyl)(3-phenyloxiran-2-yl)methanone
(4-bromophenyl)[3-(2-naphthyl)oxiran-2-yl]methanone
(4-fluorophenyl)(3-phenyloxiran-2-yl)methanone
(4-iodophenyl)(3-phenyloxiran-2-yl)methanone
(4-methoxyphenyl)(3-phenyloxiran-2-yl)methanone
(4-methylphenyl)(3-phenyloxiran-2-yl)methanone
(4-methylphenyl)[3-(2-naphthyl)oxiran-2-yl]methanol
(4-methylphenyl)[3-(2-naphthyl)oxiran-2-yl]methanone
(4-nitrophenyl)(3-phenyloxiran-2-yl)methanone
(4Z)-9-[(pentylcarbamoyl)amino]non-4-enoic acid
(5Z)-13-[(pentylcarbamoyl)amino]tridec-5-enoic acid
(8E)-13-[(pentylcarbamoyl)amino]tridec-8-enoic acid
(8Z)-12-[(hexylcarbamoyl)amino]dodec-8-enoic acid
(8Z)-12-[[(pentylcarbamoyl)amino]oxy]dodec-8-enoic acid
(8Z)-13-(4-pentyl-1H-1,2,3-triazol-1-yl)tridec-8-enoic acid
(8Z)-13-(5-pentyl-4,5-dihydro-1,3-oxazol-2-yl)tridec-8-enoic acid
(8Z)-13-(5-pentylfuran-2-yl)tridec-8-enoic acid
(8Z)-13-(heptanoylamino)tridec-8-enoic acid
(8Z)-13-[(pentylcarbamothioyl)amino]tridec-8-enoic acid
(8Z)-13-[(pentylcarbamoyl)amino]tridec-8-enoic acid
(8Z)-13-[(pentylcarbamoyl)oxy]tridec-8-enoic acid
(8Z)-13-[heptanoyl(methyl)amino]tridec-8-enoic acid
(8Z)-13-[heptanoyl(propan-2-yl)amino]tridec-8-enoic acid
(8Z)-13-[methyl(pentylcarbamoyl)amino]tridec-8-enoic acid
(8Z)-13-[methyl[methyl(pentyl)carbamoyl]amino]tridec-8-enoic acid
(8Z)-13-[[(butylamino)(oxo)acetyl]amino]tridec-8-enoic acid
(8Z)-13-[[(pentyloxy)carbonyl]amino]tridec-8-enoic acid
(8Z)-13-[[methyl(pentyl)carbamoyl]amino]tridec-8-enoic acid
(8Z)-13-[[[butyl(methyl)amino](oxo)acetyl](methyl)amino]tridec-8-enoic acid
(8Z)-14-(hexylamino)-14-oxotetradec-8-enoic acid
(8Z)-14-[(butylcarbamoyl)amino]tetradec-8-enoic acid
(8Z)-14-[hexyl(methyl)amino]-14-oxotetradec-8-enoic acid
(8Z,11Z)-16-[(ethylcarbamoyl)amino]hexadeca-8,11-dienoic acid
(E)-4-[N-((2-trifluoromethyl)benzyl)benzamide]-alpha-ethylcinnamic acid
-
(E)-N-methoxy-N-methyl 3-[4-(N-((2-trifluoromethyl)benzyl)-benzamide)]but-2-enamide
-
(E)-phenyl(3-phenyloxiran-2-yl)methanone oxime
(E)-[3-(2-naphthyl)oxiran-2-yl](phenyl)methanone oxime
(R)-1-((3,5-difluoropyridin-2-yl)methyl)-2-methyl-N-(1-phenylpropyl)-1H-benzo[d]imidazole-5-carboxamide
GSK1997132B
(R)-1-(1-cyclohexylethyl)-3-(3-phenylpropyl)urea
-
-
-
(R)-1-(1-phenylethyl)-3-(3-phenylpropyl)urea
-
-
(R)-1-(1-phenylpropyl)-3-(3-phenylpropyl)urea
-
-
(R)-1-(2,3-dihydro-1H-inden-1-yl)-3-(3-phenylpropyl)urea
-
-
(R)-1-(2-hydroxy-1-phenylethyl)-3-(3-phenylpropyl)urea
-
-
(R)-1-(3-phenylpropyl)-3-(1,2,3,4-tetrahydronaphthalen-1-yl)urea
-
-
(R)-1-(naphthalen-1-yl)ethyl)-3-(3-phenylpropyl)urea
-
-
(R)-2-phenyl-N-(3-phenylpropyl)pyrrolidine-1-carboxamide
-
-
(R)-4-(3-(3-(1-phenylethyl)ureido)propyl)benzenesulfonamide
-
-
(R)-4-cyano-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-benzamide
(R)-N-(2-(diphenylamino)ethyl)-3-(3-(1-hydroxyureido)but-1-yn-1-yl)benzamide
-
dual 5-LOX/soluble epoxide hydrolase inhibitor
-
(R)-N-(3,3-bis(4-fluorophenyl)propyl)-3-(3-(1-hydroxyureido)but-1-yn-1-yl)benzamide
-
dual 5-LOX/soluble epoxide hydrolase inhibitor
-
(R)-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-hydroxy-nicotinamide
(S)-1-(1-cyclohexylethyl)-3-(3-phenylpropyl)urea
-
-
(S)-1-(1-phenylethyl)-3-(3-phenylpropyl)urea
-
-
(S)-1-(1-phenylpropyl)-3-(3-phenylpropyl)urea
-
-
(S)-1-(2,3-dihydro-1H-inden-1-yl)-3-(3-phenylpropyl)urea
-
-
(S)-1-(2-hydroxy-1-phenylethyl)-3-(3-phenylpropyl)urea
-
-
(S)-1-(3-phenylpropyl)-3-(1,2,3,4-tetrahydronaphthalen-1-yl)urea
-
-
(S)-1-(naphthalen-1-yl)ethyl)-3-(3-phenylpropyl)urea
-
-
(S)-1-sec-butyl-3-(3-phenylpropyl)urea
-
-
(S)-2-phenyl-N-(3-phenylpropyl)pyrrolidine-1-carboxamide
-
-
(S)-4-(3-(3-(1-phenylethyl)ureido)propyl)benzenesulfonamide
-
-
(S)-4-cyano-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-benzamide
(S)-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-hydroxy-nicotinamide
1,1'-(benzene-1,3-diyldicarbonyl)bis[N-(2,4-dichlorobenzyl)piperidine-4-carboxamide]
-
55% inhibition at 200 nM
1,1'-(benzene-1,3-diyldisulfonyl)bis[N-(2,4-dichlorobenzyl)piperidine-4-carboxamide]
-
45% inhibition at 200 nM
1,1'-(butane-1,4-diyl)bis(3-[1-(adamantan-1-yl) butane-2-yl]urea)
-
1,1'-(butane-1,4-diyl)bis(3-[1-(adamantan-1-yl)ethyl]urea)
-
1,1'-(hexane-1,6-diyl)bis(3-[1-(adamantan-1-yl) butane 2 yl]urea)
-
1,1'-(hexane-1,6-diyl)bis(3-[1-(adamantan-1-yl)ethyl]urea)
-
1,1'-(octane-1,8-diyl)bis(3-[1-(adamantan-1-yl)butan 2 yl]urea)
-
1,1'-(octane-1,8-diyl)bis(3-[1-(adamantan-1-yl)ethyl]urea)
-
1,1'-(phenylene 1,4)bis(3-[3,5-dimethyl(adamantan-1-yl)]urea)
-
1,1'-(phenylene-1,4)bis(3-[1-(adamantan-1-yl)butan-2-yl]urea)
-
1,1'-(phenylene-1,4)bis(3-[1-(adamantan-1-yl)ethyl]urea)
-
1,1'-(phenylene-1,4)bis[3-([adamantan-1-yl)urea]
-
1,1,1-Trichloropropene 2,3-oxide
1,2-(ethylene)bis[[(adamant-1-yl)methyl]urea]
-
-
1,3-disubstituted carbamate derivatives
1,3-disubstituted urea derivatives
1,4-(phenylene)bis[(adamant-2-yl)urea]
-
-
1,4-(phenylene)bis[[(adamant-1-yl)ethyl-1]urea]
-
-
1,4-(phenylene)bis[[(adamant-1-yl)methyl]urea]
-
-
1,4-(tetramethylene)bis[(adamant-1-yl)methyl]urea
-
-
1,4-(tetramethylene)bis[(adamant-1-yl)urea]
-
-
1,4-(tetramethylene)bis[[(adamant-1-yl)ethyl-1]urea]
-
-
1,4-(tetramethylene)bis[[(adamant-1-yl)sec-butyl-1]urea]
-
-
1,4-(tetramthylene)bis[(adamant-2-yl)urea]
-
-
1,6-(hexamethylene)bis[[(adamant-1-yl)methyl]urea]
-
-
1,8-(octamethylene)bis[(adamant-1-yl)urea]
-
-
1,8-(octamethylene)bis[(adamant-1-ylethyl)urea]
-
potent inhibitor
1,8-(octamethylene)bis[(adamant-2-yl)urea]
-
-
1,8-(octamethylene)bis[[(adamant-1-yl)ethyl-1]urea]
-
-
1,8-(octamethylene)bis[[(adamant-1-yl)methyl]urea]
-
-
1,8-(octamethylene)bis[[(adamant-1-yl)sec-butyl-1]urea]
-
-
1-(1-acetylpiperidin-4-yl)-3-adamantan-1-yl-urea
AR9281
1-(1-acetylpiperidin-4-yl)-3-cycloheptylurea
1-(1-acetylpiperidin-4-yl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
1-(1-acetylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea
1-(1-acetylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea
1-(1-acetypiperidin-4-yl)-3-adamantanylurea
1-(1-adamantyl)-3-(1-propionyl-piperidin-4-yl)urea
-
1-(1-butanoylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea
1-(1-cyclopropylethyl)-3-phenylurea
-
1-(1-isobutyrylpiperidin-4-yl)-3-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)urea
binding structure at the enzyme's active site, docking analysis and molecular dynamics simulations using the PDB ID 4JNC structure as template
-
1-(1-methanesulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)-urea
1-(1-methylsulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)-urea
1-(1-methylsulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxyphenyl)-urea
1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy) phenyl) urea
1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)-urea
1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea
1-(2-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylic acid
-
-
1-(2-hydroxyphenyl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
1-(3,4-dichlorophenyl)-3-(4-phenoxyphenyl)urea
-
-
1-(3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)-3-phenylpropan-1-one
1-(3,5-dimethyladamant-1-yl)-3-(1-propionylpiperidin-4-yl)urea
-
1-(3-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylic acid
-
-
1-(3-(5-(hydroxyureido)methyl-2-methoxyphenoxy)propyl)-3-[4-(trifluoromethoxy)phenyl]urea
i.e. KM55, a dual inhibitor of 5-lipoxygenase (5-LO) and soluble epoxide hydrolase (sEH), synthesis and evaluation, overview. Applied to leukocytes, it strongly inhibits the lipopolysaccharide (LPS)-induced adhesion of the leukocytes to endothelial cells. KM55 is a designed multi-target ligand which inhibits the enzymatic activity of 5-LO and sEH
1-(3-ethyladamant-1-yl)-3-(1-propionylpiperidin-4-yl)urea
-
1-(3-ethyladamant-1-ylmethyl)-3-(1-propionylpiperidin-4-yl)urea
-
1-(3-hydroxypropyl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
1-(3-[[3-(morpholin-4-yl)propyl]sulfonyl]phenyl)-3-[4-(trifluoromethyl)phenyl]urea
-
1-(4-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylic acid
-
-
1-(4-(N1-methyl-N2-methyl-N2-(methyloxy)oxalamido)-benzyl)-3-adamantylurea
-
1-(4-(N2-(tetrahydro-2H-pyran-2-yloxy)oxalamido)benzyl)-3-adamantylurea
-
1-(4-(N2-methyl-N2-(methyloxy)oxalamido)benzyl)-3-adamantylurea
-
1-(4-(N2-methyloxyoxalamido)benzyl)-3-adamantylurea
-
1-(4-(N2-tert-butyloxyoxalamido)benzyl)-3-adamantylurea
-
1-(4-acetylphenyl)-N-(5-chloro-1,3-benzoxazol-2-yl)piperidine-4-carboxamide
IC50 value in COS-7 cell assay 4.7 nM, 45% remiaining stability in human microsomes
1-(4-acetylphenyl)-N-(5-methyl-1,3-benzoxazol-2-yl)piperidine-4-carboxamide
IC50 value in COS-7 cell assay 5.8 nM, 53% remiaining stability in human microsomes
1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea
1-(4-chlorophenyl)-3-[4-[4-(morpholin-4-yl)benzoyl]cyclohex-2-yn-1-yl]urea
-
1-(4-tert-butylphenyl)-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea
1-(4-trifluoro-methoxy-phenyl)-3-(1-propionylpiperidin-4-yl)urea
1-(4-[[4-(2-methoxyethyl)piperazin-1-yl]carbonyl]phenyl)-3-[4-(trifluoromethyl)phenyl]urea
-
1-(5-hydroxypentyl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
1-(adamant-1-ylmethyl)-3-(1-propionylpiperidin-4-yl)urea
-
1-(adamantan-1-yl)-3-(1-propionylpiperidin-4-yl)urea
1-(cis-4-ethylcyclohexyl)-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea
1-(cis-4-methoxycyclohexyl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
1-(cyclohexylsulfonyl)-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide
-
27% inhibition at 200 nM
1-(trifluoromethoxyphenyl-3-(1-methylsulfonyl)piperidin-4-yl)urea
-
-
1-adamantan-1-yl-3-(5-(2-(2-ethoxyethoxy)ethoxy)-pentyl)urea
-
-
1-adamantan-1-yl-3-(5-(2-(2-ethoxyethoxy)ethoxy)pentyl)urea
1-adamantan-1-yl-3-(5-(2-[2-(2,2,2-trifluoroethoxy)ethoxy]-ethoxy)pentyl)urea
-
-
1-adamantan-1-yl-3-(5-(2-[2-(4-ethylphenoxy)ethoxy]-ethoxy)pentyl)urea
-
-
1-adamantan-1-yl-3-(5-butoxypentyl)urea
-
-
1-adamantan-1-yl-3-(5-hexoxypropyl)urea
-
-
1-adamantan-1-yl-3-(5-pentoxybutyl)urea
-
-
1-adamantan-1-yl-3-(5-propyloxyhexyl)urea
-
-
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
1-adamantan-1-yl-3-(5-[4-propyloxy]butyl)-urea
-
-
1-adamantan-1-yl-3-(5-[4-propyloxy]propyl)-urea
-
-
1-adamantan-1-yl-3-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]urea
-
IK-950
1-adamantan-1-yl-3-{5-[2-(2-ethoxy-ethoxy)-ethoxy]-pentyl}-urea
i.e. AEPU, shows beneficial effects in cardiac hypertrophy, evaluation in a clinically relevant murine model of myocardial infarction, overview
1-adamantan-3-(5-(2-(2-ethylethoxy) ethoxy)pentyl) urea
1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea
1-adamantanyl-3-(5-(2-(2-ethoxyethoxy)ethoxy)pentyl)urea
1-adamantyl-3-(1-acetylpiperidin-4-yl)-urea
-
-
1-adamantyl-3-(5-[2-(2-ethylethoxy)ethoxy]pentyl)urea
-
i.e. compound 950
1-adamantyl-3-cyclohexylurea
1-benzyl-3-(3-phenylpropyl)urea
-
-
1-benzyl-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
1-Benzylimidazole
-
microsomal activity with cis-stilbene oxide as substrate
1-cycloheptyl-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea
1-cyclohexyl-3-dodecyl urea
1-cyclohexyl-3-dodecylurea
1-cyclohexyl-3-ethyl urea
1-cyclohexyl-3-hexyl urea
1-cyclohexyl-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea
1-cyclohexyl-3-[3-(3-morpholin-4-ylpropoxy)phenyl]urea
-
-
1-sec-butyl-3-(3-phenylpropyl)urea
-
-
1-trichloropropene oxide
-
-
1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl) urea
1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl)-urea
1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl)urea
1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea
1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)-urea
1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)urea
-
1-[(1-chloroisoquinolin-5-yl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide
-
30% inhibition at 200 nM
1-[(2,4-dichlorobenzyl)carbamoyl]piperidine-4-carboxylic acid
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-(2-fluorophenyl)piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-(2-hydroxyphenyl)piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-(2-methylphenyl)piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-(2-methylpropyl)piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-fluorophenyl)piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-hydroxyphenyl)piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-methoxyphenyl)piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-nitrophenyl)piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-phenoxyphenyl)piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-(6-methoxy-1,3-benzodioxol-5-yl)piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-(isoquinolin-5-yl)piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-(naphthalen-2-yl)piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-(quinolin-3-yl)piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-(quinolin-6-yl)piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-(quinolin-8-yl)piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-(tricyclo[3.3.1.13,7]dec-1-yl)piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-phenylpiperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-[(1R,2S)-2-phenylcyclopropyl]piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(morpholin-4-yl)phenyl]piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(piperidin-1-yl)phenyl]piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(propan-2-yl)phenyl]piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(trifluoromethoxy)phenyl]piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(trifluoromethyl)phenyl]piperidine-4-carboxamide
-
-
1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-[(trifluoromethyl)sulfonyl]phenyl]piperidine-4-carboxamide
-
-
1-[(2-bromophenyl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide
-
63% inhibition at 200 nM
1-[(2-chloroethyl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide
-
31% inhibition at 200 nM
1-[(4-bromoisoquinolin-5-yl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide
-
37% inhibition at 200 nM
1-[(4-bromophenyl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide
-
32% inhibition at 200 nM
1-[(4-chloro-2,5-dimethylphenyl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide
-
97% inhibition at 200 nM
1-[(4-tert-butylphenyl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide
-
85% inhibition at 200 nM
1-[(5-bromothiophen-2-yl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide
-
43% inhibition at 200 nM
1-[(5-chlorothiophen-2-yl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide
-
52% inhibition at 200 nM
1-[1-(2-methylbutanoyl)piperidin-4-yl]-3-[4-(propan-2-yl)phenyl]urea
1-[1-(2-methylbutanoyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
1-[1-(2-methylbutanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
1-[1-(3-methylbutanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
1-[1-(4,4,4-trifluorobutanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
1-[1-(butylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
1-[1-(butylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
1-[1-(cyclopropylcarbonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
1-[1-(cyclopropylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
1-[1-(ethylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
1-[1-(methylsulfonyl)piperidin-4-yl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
1-[1-(methylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
1-[1-(methylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
1-[1-(propan-2-ylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
1-[1-(propylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
1-[1-[(2,2,2-trifluoroethyl)sulfonyl]piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
1-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
1-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
1-[2-methyl-6-(methylamino)pyridin-4-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
-
1-[2-methyl-6-(methylamino)pyrimidin-4-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
-
1-[2-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylic acid
-
-
1-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]thiourea
-
-
1-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]urea
-
-
1-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[4-(trifluoromethoxy)phenyl]urea
-
-
1-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[4-(trifluoromethyl)phenyl]urea
-
-
1-[3-(4-nitrophenyl)oxiran-2-yl]ethanol
1-[3-(4-nitrophenyl)oxiran-2-yl]ethanone
1-[3-(morpholin-4-ylcarbonyl)phenyl]-3-[4-(trifluoromethyl)phenyl]urea
-
1-[3-(trifluoromethyl)pyridin-2-yl]piperazine
-
1-[3-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)benzyl]-1H-pyrrole-2-carboxylic acid
-
-
1-[3-methyl-5-(methylamino)phenyl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
-
1-[3-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylic acid
-
-
1-[4,6-bis(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
-
1-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea
1-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]-3-[1-(3,3,3-trifluoropropanoyl)piperidin-4-yl]urea
1-[4-(dimethylamino)-6-methyl-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
-
1-[4-(methylamino)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
-
1-[4-(methylamino)-6-phenyl-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
-
1-[4-(trifluoromethyl)phenyl]-3-[1-(3,3,3-trifluoropropanoyl)piperidin-4-yl]urea
1-[4-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-4-ol
-
1-[4-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)benzyl]-1H-pyrrole-2-carboxylic acid
-
-
1-[4-cyclohexyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
-
1-[4-ethyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
-
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethoxy)benzyl]piperidine-4-carboxamide
-
-
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[3-(trifluoromethoxy)benzyl]piperidine-4-carboxamide
-
-
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[[[4-bromo-2-(trifluoromethoxy)]-phenyl]methyl]-4-piperidinecarboxamide
-
-
1-[4-methyl-6-(methylamino)pyridin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
-
1-[4-methyl-6-(methylamino)pyrimidin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
-
1-[4-methyl-6-(morpholin-4-yl)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
-
1-[4-methyl-6-(propan-2-ylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
-
1-[4-[(2-methoxyethyl)amino]-6-methyl-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
-
1-[4-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylic acid
-
-
1-[4-[2-(2-ethoxyethoxy)ethoxy]cyclohexyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
1-[4-[2-(2-ethoxyethoxy)ethoxy]phenyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
1-[4-[2-(morpholin-4-yl)ethoxy]cyclohexyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
1-[4-[4-(hydroxymethyl)phenoxy]cyclohexyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
-
1-[4-[[2-(dimethylamino)ethyl](methyl)amino]-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
-
1-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
1-[5-[3-(morpholin-4-yl)propoxy]pentyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
1-[6-methyl-2-(methylamino)pyrimidin-4-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
-
1-[6-methyl-4-(methylamino)pyridin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
-
1-[cis-4-(4-fluorophenoxy)cyclohexyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
1-[cis-4-(4-methoxyphenoxy)cyclohexyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
1-[cis-4-(benzyloxy)cyclohexyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
1-[cis-4-(cyclohexylmethoxy)cyclohexyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
1-[cis-4-[(2-methylbenzyl)oxy]cyclohexyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
1-[cis-4-[(4-bromobenzyl)oxy]cyclohexyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
1-[[1-((adamant-1-yl)methylcarbamoyl)piperidin-4-yl]methyl]-3-[(adamant-1-yl)methyl]urea
-
-
1-[[4-(acetylamino)phenyl]sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide
-
53% inhibition at 200 nM
1-[[4-(trifluoromethoxy)phenyl]carbamoyl]piperidine-4-carboxylic acid
-
10-(sulfooxy)octadecanoic acid
-
IC50 is 0.028 mM
11-nonyloxy-undec-8-enoic acid
-
i.e. 11-nonyloxy-undec-8-enoic acid
12,13-epoxyoctadecenoic acid
-
12,13-dihydroxyoctadecenoic acid reverses the effects of enzyme inhibition
12-(3-adamantan-1-yl-ureido) 2-chlorobenzyl dodecanoate
-
-
12-(3-adamantan-1-yl-ureido) 2-methylpropyl dodecanoate
-
-
12-(3-adamantan-1-yl-ureido) butan-2-yl dodecanoate
-
-
12-(3-adamantan-1-yl-ureido) butyl dodecanoate
-
-
12-(3-adamantan-1-yl-ureido) ethyl dodecanoate
-
-
12-(3-adamantan-1-yl-ureido) N-(methylsulfonyl)dodecanylamide
-
-
12-(3-adamantan-1-yl-ureido) N-(phenylsulfonyl)dodecanylamide
-
-
12-(3-adamantan-1-yl-ureido) prop-2-en-1-yl dodecanoate
-
-
12-(3-adamantan-1-yl-ureido) prop-2-yn-1-yl dodecanoate
-
-
12-(3-adamantan-1-yl-ureido) propan-2-yl dodecanoate
-
-
12-(3-adamantan-1-yl-ureido) propyl dodecanoate
-
-
12-(3-adamantan-1-yl-ureido) tert-butyl dodecanoate
-
-
12-(3-adamantan-1-yl-ureido)-dodecanoic acid
12-(3-adamantan-1-yl-ureido)-dodecanoic acid butyl ester
12-(3-adamantan-1-yl-ureido)-dodecanoic acid butylester
12-(3-adamantan-1-yl-ureido)dodecanoic acid
12-(3-adamantan-1-yl-ureido)dodecanoic acid butyl ester
12-(3-adamantan-1-ylureido)-dodecanoic acid
12-(3-adamantan-1-ylureido)-dodecanoic acid polyethylene glycol ester
-
-
-
12-(3-adamantan-1-ylureido)dodecanoic acid
12-(3-adamantan-1-ylureido)dodecanoic acid butyl ester
12-(3-adamantane-1-yl-ureido)-dodecanoic acid
12-(3-adamantane-1-yl-ureido)dodecanoic acid
-
shows an IC50 of 0.00013 mg/ml
12-(3-adamantyl-ureido)-dodecanoic acid
12-(3-adamantylureido)-dodecanoic acid
-
-
12-sulfonoxy-cis-9-octadecenoic acid
-
IC50 is above 0.1 mM
12-sulfonoxy-trans-9-octadecenoic acid
-
IC50 is 0.016 mM
12-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]dodecanoic acid
12-[[(cyclohexylamino)carbonyl]amino]-dodecanoic acid
i.e. CUDA
12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid
12[3-adamantane-1-yl-ureido]-dodecanoic acid
i.e. AUDA
13-(heptanoylamino)tridec-5-ynoic acid
13-[(pentylcarbamoyl)amino]tridec-8-ynoic acid
13-[methyl[methyl(pentyl)carbamoyl]amino]tridec-5-ynoic acid
2,3-epoxy-1,3-diphenyl-propan-1-one
2,3-epoxy-1-(4-bromophenyl)-3-phenyl-propan-1-one
2,3-epoxy-1-(4-ethylphenyl)-3-phenyl-propan-1-one
2,3-epoxy-1-(4-fluorophenyl)-3-phenyl-propan-1-one
2,3-epoxy-1-(4-methoxyphenyl)-3-phenyl-propan-1-one
2,3-epoxy-1-(4-nitroxyphenyl)-3-phenyl-propan-1-one
2,3-epoxy-1-(4-phenylphenyl)-3-phenyl-propan-1-one
2,3-epoxy-3-(4-bromophenyl)-1-phenyl-propan-1-one
2,3-epoxy-3-(4-ethylphenyl)-1-phenyl-propan-1-one
2,3-epoxy-3-(4-fluorophenyl)-1-phenyl-propan-1-one
2,3-epoxy-3-(4-methoxyphenyl)-1-phenyl-propan-1-one
2,3-epoxy-3-(4-n-butylphenyl)-1-phenyl-propan-1-one
2,3-epoxy-3-(4-nitrophenyl)-1-phenyl-propan-1-one
2,3-epoxy-3-(4-phenylphenyl)-1-phenyl-propan-1-one
-
IC50: 0.00014 mM
2,4-dichloro-N-[4-[3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]benzamide
-
2-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazole
-
2-(2,4-dichlorophenyl)-1-[6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl]ethanone
2-(2,6-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
12.34% inhibition
2-(2-fluorophenyl)-N-[(5-methylthiophen-2-yl)methyl]ethan-1-amine
-
2-(2-naphthyl)-3-(phenylsulfinyl)oxirane
2-(3,4-dihydroxy-5-methoxyphenyl)-5,7-dihydroxy-1-benzopyran-1-ium-3-yl beta-D-glucopyranoside
mixed-type inhibition
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-1-benzopyran-1-ium
noncompetitive inhibition
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-1-benzopyran-1-ium-3-yl beta-D-glucopyranoside
noncompetitive inhibition
2-(benzylamino)-N-[4-[3-(pyridin-3-yl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]pyridine-3-carboxamide
-
2-(hydroxymethyl)-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
-
2-(piperazin-1-yl)pyridine-3-carbonitrile
-
2-(tricyclo[3.3.1.13,7]dec-1-yl)-N-[1-(trifluoroacetyl)piperidin-4-yl]acetamide
2-([[2-(adamantan-1-yl)ethyl]amino]methyl)phenol
2-Bromo-4'-nitroacetophenone
2-cyclohexa-1,5-dien-1-yl-3-(phenylsulfinyl)oxirane
2-cyclohexa-1,5-dien-1-yl-3-[methoxy(phenyl)methyl]oxirane
2-cyclohexyl-N-[3-(3-morpholin-4-ylpropoxy)phenyl]acetamide
-
-
2-cyclopentyl-N-(1,3-thiazol-2-yl)acetamide
-
2-ethyl 3-[4-(N-(4-fluoro(2-trifluoromethyl)benzyl)-benzamide)]propionic acid
-
2-ethyl-3-[3-(N-((2-trifluoromethyl)benzyl)benzamide)]-propionic acid
-
2-ethyl-3-[4-(N-((2-bromo)benzyl)benzamide)]propionic acid
34% inhibition at 0.01 mM, pH 7.0, 22°C
2-ethyl-3-[4-(N-((2-chloro)benzyl)benzamide)]propionic acid
20% inhibition at 0.01 mM, pH 7.0, 22°C
2-ethyl-3-[4-(N-((2-methyl)benzyl)benzamide)]propionic acid
25% inhibition at 0.01 mM, pH 7.0, 22°C
2-ethyl-3-[4-(N-((2-trifluoromethoxy)benzyl)benzamide)]-propionic acid
23% inhibition at 0.01 mM, pH 7.0, 22°C
2-ethyl-3-[4-(N-((2-trifluoromethyl)benzyl)benzamide)]-propionic acid
-
2-ethyl-3-[4-(N-((4-chloro)benzyl)benzamide)]propionic acid
-
2-ethyl-3-[4-(N-((4-fluoro)benzyl)benzamide)]propionic acid
28% inhibition at 0.01 mM, pH 7.0, 22°C
2-ethyl-3-[4-(N-((4-methoxy)benzyl)benzamide)]propionic acid
34% inhibition at 0.01 mM, pH 7.0, 22°C
2-ethyl-3-[4-(N-((4-phenoxy)benzyl)benzamide)]propionic acid
-
2-ethyl-3-[4-(N-((4-trifluoromethoxy)benzyl)benzamide)]-propionic acid
-
2-ethyl-3-[4-(N-((4-trifluoromethyl)benzyl)benzamide)]-propionic acid
-
2-ethyl-3-[4-(N-(4-methoxy(2-trifluoromethyl)benzyl)-benzamide)]propionic acid
-
2-ethyl-3-[4-(N-benzylbenzamide)]propionic acid
4% inhibition at 0.01 mM, pH 7.0, 22°C
2-hydroxy-N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]acetamide
-
-
2-hydroxy-N-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
-
-
2-hydroxy-N-[3-(3-morpholin-4-ylpropoxy)phenyl]-4-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]butanamide
-
-
2-methoxy-4-[7-methoxy-3-methyl-5-[(1E)-prop-1-en-1-yl]-1-benzofuran-2-yl]phenol
82.46% inhibition
2-methyl 3-[4-(N-((2-Trifluoromethyl)benzyl)benzamide)]-propionic acid
-
2-methyl-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
-
2-methylglycidyl 4-nitrobenzoate
-
IC50 for the S-enantiomer is 0.717 mM, the R-enantiomer shows 25% inhibition at 0.2 mM
2-naphthyl(3-phenyloxiran-2-yl)methanone
2-oxo-2,3-dihydro-1,3-benzoxazol-4-yl 4-methylbenzoate
-
-
2-phenyl-3-[4-(N-((2-trifluoromethyl)benzyl)benzamide)]-propionic acid
-
2-propyl-3-[4-(N-((2-trifluoromethyl)benzyl)benzamide)]-propionic acid
-
2-[(4-[3-[3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl]propanoyl]piperazin-1-yl)methyl]-4H-pyrido[1,2-a]pyrimidin-4-one
-
2-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-N-[4-(trifluoromethoxy)phenyl]acetamide
2-[2-(adamantan-1-yl)ethyl]-N-(3,5-dimethyladamantan-1-yl)hydrazine-1-carboxamide
2-[2-(adamantan-1-yl)ethyl]-N-[(adamantan-1-yl)methyl]hydrazine-1-carboxamide
2-[3-(adamantan-1-yl)propyl]-N-(3,5-dimethyladamantan-1-yl)hydrazine-1-carboxamide
2-[4-(N-((2-trifluoromethyl)benzyl )benzamide)]-cyclopropanecarboxylic acid
-
2-[methoxy(phenyl)methyl]-3-(2-naphthyl)oxirane
3,3-dimethylglycidyl 4-nitrobenzoate
-
IC50 for the S-enantiomer is 0.012 mM, 23% inhibition at 5 mM of the R-enantiomer
3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl[4-(trifluoromethyl)phenyl]methanone
3-(2-amino-1,3-thiazol-4-yl)-5-methyl-1-(tetrahydrofuran-2-ylmethyl)-1H-pyrrol-2-ol
-
3-(3-(1-hydroxyureido)but-1-yn-1-yl)-N-(2-(trifluoromethyl)-benzyl)benzamide
-
dual 5-LOX/soluble epoxide hydrolase inhibitor
-
3-(3-(1-hydroxyureido)but-1-yn-1-yl)-N-(3-phenyl-3-(4-(trifluoromethoxy)phenyl)propyl)benzamide
-
dual 5-LOX/soluble epoxide hydrolase inhibitor
-
3-(3-(1-hydroxyureido)but-1-yn-1-yl)-N-(4-methoxy-2-(trifluoromethyl)benzyl)-benzamide
-
dual 5-LOX/soluble epoxide hydrolase inhibitor
-
3-(3-(1-hydroxyureido)hex-1-yn-1-yl)-N-(2-(trifluoromethyl)-benzyl)benzamide
-
dual 5-LOX/soluble epoxide hydrolase inhibitor
-
3-(3-amino-3-oxopropyl)-N-(4-chlorophenyl)-3-phenylpiperidine-1-carboxamide
3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propylamine
3-(hydroxymethyl)-N-(1-phenylethyl)piperidine-1-carboxamide
-
3-(hydroxymethyl)-N-(2-methylbenzyl)piperidine-1-carboxamide
-
3-(hydroxymethyl)-N-(3-methylbenzyl)piperidine-1-carboxamide
-
3-(hydroxymethyl)-N-(4-methylbenzyl)piperidine-1-carboxamide
-
3-(hydroxymethyl)-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
-
3-([cis-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]cyclohexyl]oxy)benzoic acid
3-([[(adamantan-1-yl)methyl]carbamoyl]amino)adamantan-1-yl trifluoroacetate
3-methyl-3-phenyl-N-(4-(pyridin-3-yl)benzyl)piperidine-1-carboxamide
3-methyl-3-phenyl-N-(pyridin-4-yl)piperidine-1-carboxamide
3-methyl-3-phenyl-N-[3-(pyridin-3-yl)propyl]piperidine-1-carboxamide
3-methyl-3-phenyl-N-[3-[(1S,2S)-2-phenylcyclopropyl]benzyl]piperidine-1-carboxamide
3-methyl-3-phenyl-N-[3-[2-(quinoxalin-6-yl)ethyl]benzyl]piperidine-1-carboxamide
3-methyl-3-phenyl-N-[[2'-(trifluoromethyl)biphenyl-4-yl]methyl]piperidine-1-carboxamide
3-methyl-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
-
3-[1-[(4-chlorophenyl)carbamoyl]-3-(pyridin-2-yl)piperidin-3-yl]propanoic acid
3-[1-[(4-chlorophenyl)carbamoyl]-3-(pyridin-3-yl)piperidin-3-yl]propanoic acid
3-[1-[(4-chlorophenyl)carbamoyl]-3-(pyridin-4-yl)piperidin-3-yl]propanoic acid
3-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]propanoic acid
3-[1-[(4-chlorophenyl)carbamoyl]-3-[3-(trifluoromethyl)phenyl]piperidin-3-yl]propanoic acid
3-[1-[(4-chlorophenyl)carbamoyl]-3-[4-(trifluoromethyl)phenyl]piperidin-3-yl]propanoic acid
3-[3-(biphenyl-4-yl)-1-[(4-chlorophenyl)carbamoyl]piperidin-3-yl]propanoic acid
3-[4-(benzyloxy)phenyl]propan-1-ol
-
3-[4-(N-((2-trifluoromethyl)benzyl)benzamide)]propionic acid
-
3-[4-[(1-[[(1R,3S)-2,2-dimethyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
3-[4-[(1-[[(1S,2R)-2-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
3-[4-[(1-[[(1S,2R,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
3-[4-[(1-[[(1s,2R,3S)-2,3-bis(4-fluorophenyl)cyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
3-[4-[(1-[[(1s,2R,3S)-2,3-diphenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
3-[4-[(1-[[(1S,2S,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
4'-(methylsulfonyl)-N-[4-[3-(pyridin-3-yl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]biphenyl-3-carboxamide
-
4'-azidochalcone oxide
-
-
4'-fluorochalcone oxide
-
-
4'-hydroxy-N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide
4'-methylchalcone oxide
-
-
4'-phenylchalcone oxide
-
-
4'-[([2-(trifluoromethyl)phenyl]methyl)carbamoyl][1,1'-biphenyl]-3-carboxylic acid
-
4'-[([2-(trifluoromethyl)phenyl]methyl)carbamoyl][1,1'-biphenyl]-4-carboxylic acid
-
4,4-diphenyl-N-(pyridin-3-yl)-butyramide
4,5-dimethoxy-2-nitrophenyl 4-[(2,4-dichlorobenzyl)carbamoyl]piperidine-1-carboxylate
-
71% inhibition at 200 nM
4-((4-(3-(adamantan-1-yl)ureido)trans-cyclohexyl)oxy)benzoic acid
4-((4-[3-(2-oxo-1-adamantyl)-ureido]cyclohexyl)oxy)benzoic acid
-
4-((4-[3-(2-oxoadamant-1-yl)ureido]cyclohexyl)oxy)benzoic acid
-
4-((4-[3-(3,5,7-trimethyladamant-1-yl)ureido]cyclohexyl)oxy)benzoic acid
-
4-((4-[3-(3,5-dimethyladamant-1-yl)ureido]cyclohexyl)oxy)benzoic acid
-
4-((4-[3-(3-chloroadamant-1-yl)ureido]cyclohexyl)oxy)benzoic acid
-
4-((4-[3-(3-ethyladamant-1-yl)ureido]cyclohexyl)oxy)benzoic acid
-
4-((4-[3-(3-ethyladamant-1-ylmethyl)ureido]cyclohexyl)oxy)benzoic acid
-
4-((4-[3-(3-methyladamant-1-yl)ureido]cyclohexyl)oxy)benzoic acid
-
4-((4-[3-(adamant-!-ylmethyl)ureido]cyclohexyl)oxy)benzoic acid
-
4-(1,2,4-oxadiazol-3-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
4-(1,3,4-oxadiazol-2-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
4-(1,3-benzoxazol-2-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
4-(1-methyl-1H-1,2,3-triazol-4-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
4-(1H-pyrrol-1-yl)-N-[4-(trifluoromethoxy)phenyl]-piperidinecarboxamide
-
4-(1H-pyrrol-1-yl)-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
-
4-(2,3-dihydro-1H-1,2,3-triazol-1-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
4-(2-cyanophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide
-
4-(3-(1-hydroxyureido)but-1-yn-1-yl)-N-(2-(trifluoromethyl)-benzyl)benzamide
-
dual 5-LOX/soluble epoxide hydrolase inhibitor, displays cellular activity in human polymorphonuclear leukocytes, oral bioavailability, and target engagement in vivo and demonstrates anti-inflammatory and anti-fibrotic efficiency in a kidney injury model caused by unilateral ureteral obstruction in mice
-
4-(3-adamantan-1-yl-ureido) butyric acid
-
4-(3-adamantan-1-yl-ureido) butyric acid methyl ester
-
4-(3-benzoyloxiran-2-yl)benzoic acid
4-(3-cyanophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide
4-(3-cyclohexylureido)-butyric acid
binding structure analysis
4-(3-cyclohexylureido)-butyric acid methyl ester
-
4-(3-cyclohexylureido)-heptanoic acid
binding structure analysis
4-(3-cyclohexylureido)-hexanoic acid
binding structure analysis
4-(3-cyclohexylureido)-hexanoic acid methyl ester
-
4-(3-hydroxy-4-methyl-1,2-oxazol-5-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
4-(3-methyl-1,2,4-oxadiazol-5-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
4-(4-chlorophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide
-
4-(4-cyanophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide
-
4-(4-methyl-4H-1,2,4-triazol-3-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
4-(5-phenyl-3-[3-[3-(3-trifluoromethyl-phenyl)-ureido]-propyl]-pyrazol-1-yl)-benzenesulfonamide
dual inhibitor of cyclooxygenase-2 and soluble epoxide hydrolase
4-(5-phenyl-3-[3-[3-(4-trifluoromethoxy-phenyl)-ureido]-propyl]-pyrazol-1-yl)-benzenesulfonamide
dual inhibitor of cyclooxygenase-2 and soluble epoxide hydrolase
4-(5-phenyl-3-[3-[3-(4-trifluoromethyl-phenyl)-ureido]-propyl]-pyrazol-1-yl)-benzenesulfonamide
4-(5-[1-[(2-phenylcyclopropyl)carbamoyl]piperidin-4-yl]-1,2,4-oxadiazol-3-yl)benzoic acid
-
4-(hydroxymethyl)-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
-
4-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
-
4-([1-[(2,4-dichlorobenzyl)carbamoyl]piperidin-4-yl]oxy)benzoic acid
-
4-([3-(2-naphthyl)oxiran-2-yl]carbonyl)benzoic acid
4-([3-(4-fluorophenyl)oxiran-2-yl]carbonyl)benzoic acid
4-([cis-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]cyclohexyl]oxy)benzoic acid
-
4-([trans-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]cyclohexyl]oxy)benzoic acid
4-azidochalcone oxide
-
-
4-benzyl-3,4-dihydroquinoxalin-2(1H)-one
-
4-benzyl-N-(2,4-dichlorobenzyl)-4-hydroxypiperidine-1-carboxamide
-
4-benzyloxychalcone oxide
-
-
4-bromo-4'-methoxychalcone
4-cyano-N-(2-(trifluoromethyl)benzyl)benzamide
-
4-cyano-N-[(3S)-3-(4-fluorophenyl)-3-[4-(methanesulfonyl)phenyl]propyl]benzamide
-
4-cyano-N-[3,3-bis-(4-fluorophenyl)-propyl]-benzamide
4-fluoro-chalcone oxide
-
0.1 mM, 87% inhibition of epoxide hydrolase activity, 8% inhibition of phosphatase activity
4-hydroxy-3,5-dimethoxybenzaldehyde
13.48% inhibition
4-hydroxy-3-methoxybenzaldehyde
19.25% inhibition
4-hydroxymercuribenzoate
-
-
4-iodo-N-(2-(trifluoromethyl)-benzyl)benzamide
-
4-methyl-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
-
4-methylchalcone oxide
-
-
4-nitrobenzenesulfonyl fluoride
4-nitrophenyl 4-[(2,4-dichlorobenzyl)carbamoyl]piperidine-1-carboxylate
-
41% inhibition at 200 nM
4-nitrophenyl sulfate
-
IC50 is above 0.1 mM
4-oxo-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
4-oxo-N-(2-phenylcyclopropyl)-6-(pyridin-4-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
4-oxo-N-(3-phenylcyclopentyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
4-oxo-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
4-oxo-N-[(1S,2R)-2-phenylcyclopropyl]-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
4-phenyl-chalcone oxide
-
0.1 mM, complete inhibition of epoxide hydrolase activity, 11% inhibition of phosphatase activity
4-[(3-phenyloxiran-2-yl)carbonyl]benzoic acid
4-[(4-[[(3-methyladamantan-1-yl)carbamoyl]amino]cyclohexyl)oxy]benzoic acid
-
4-[(4-[[(adamantan-1-yl)carbamoyl]amino]cyclohexyl)oxy]benzoic acid
-
-
4-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]benzoic acid
-
-
4-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]butanoic acid
4-[3-(4-fluorobenzoyl)oxiran-2-yl]benzoic acid
4-[3-(isoquinolin-1-yl)-1,2,4-oxadiazol-5-yl]-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]-N-(1,2,3,4-tetrahydronaphthalen-2-yl)piperidine-1-carboxamide
-
4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)piperidine-1-carboxamide
-
4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]-N-[4-(trifluoromethyl)phenyl]piperidine-1-carboxamide
-
4-[3-[4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
-
4-[5-(cyclohexylamino)-2-(4-ethylpiperazin-1-yl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl]-2,6-dimethoxyphenol
-
4-[[(1r,4r)-4-([[(adamantan-1-yl)methyl]carbamoyl]amino)cyclohexyl]oxy]benzoic acid
4-[[(1r,4r)-4-[[(3,5,7-trimethyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
4-[[(1r,4r)-4-[[(3,5-dimethyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
4-[[(1r,4r)-4-[[(3-chloroadamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
4-[[(1r,4r)-4-[[(3-ethyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
4-[[(1r,4r)-4-[[(3-methyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
4-[[(2R,5R)-5-[[(2-oxoadamantan-1-yl)carbamoyl]amino]piperidin-2-yl]oxy]benzoic acid
4-[[([4-[(4-[(2-phenylethyl)amino]-6-[[(2R)-2-phenylpropyl]amino]-1,3,5-triazin-2-yl)amino]cyclohexyl]carbonyl)amino]methyl]benzoic acid
-
4-[[4-(azepan-1-yl)-6-(methylamino)-1,3,5-triazin-2-yl]amino]-N-[2-(trifluoromethoxy)benzyl]cyclohexanecarboxamide
-
4-[[4-([[4-(trifluoromethyl)phenyl]carbamoyl]amino)cyclohexyl]sulfonyl]benzoic acid
-
4-[[cis-4-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)cyclohexyl]oxy]benzoic acid
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
36.86% inhibition
5,6,7-trihydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one
35.58% inhibition
5,6-dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl D-threo-hexopyranosiduronic acid
75.86% inhibition
5,7,8-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
15.96% inhibition
5,7-dihydroxy-2-(2-hydroxy-6-methoxyphenyl)-4H-1-benzopyran-4-one
65.12% inhibition; 76.33% inhibition
5,7-dihydroxy-2-(2-hydroxyphenyl)-4H-1-benzopyran-4-one
34.96% inhibition
5,7-dihydroxy-2-(2-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
34.82% inhibition
5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-1-benzopyran-1-ium-3-yl beta-D-galactopyranoside
mixed-type inhibition
5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-1-benzopyran-1-ium-3-yl beta-D-glucopyranoside
noncompetitive inhibition
5,7-dihydroxy-2-phenyl-4H-1-benzopyran-4-one
24.33% inhibition
5,7-dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one
75.88% inhibition
5,7-dihydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one
20.88% inhibition
5-(4-bromobenzyl)-1,3-thiazol-2-amine
-
5-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
-
5-benzyl-N-phenyl-1,3,4-oxadiazol-2-amine
-
5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxy-4H-1-benzopyran-4-one
20.83% inhibition
5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
25.64% inhibition
5-methyl-N-(2-phenylethyl)-4,5-dihydro-1,3-thiazol-2-amine
-
5-phenyl-N-[4-(trifluoromethyl)benzyl]-1,2-oxazol-3-amine
-
5-phenyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazol-3-amine
-
5-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]pentanoic acid
5-[[(adamantan-1-yl)carbamoyl]amino]pentanoic acid
6'-(methylsulfonyl)-N-(2-phenylcyclopropyl)-1H,4'H-spiro[azepane-4,3'-chromene]-1-carboxamide
6-(1-methyl-1H-pyrazol-5-yl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
6-(1H-indol-5-yl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
-
6-(2-fluorophenyl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
-
6-(3-methylpyridin-2-yl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
-
6-(isoquinolin-5-yl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
-
6-(methylsulfonyl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
6-(pyridin-3-yl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
-
6-(pyridin-4-yl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
-
6-(trifluoromethyl)-1,3-benzothiazol-2-amine
-
6-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
-
6-amino-1-methyl-5-(piperidin-1-yl)pyrimidine-2,4(1H,3H)-dione
-
6-amino-N-(2,4-dichlorobenzyl)pyridine-3-carboxamide
6-amino-N-(3,3-diphenylpropyl)pyridine-3-carboxamide
6-cyano-N-[3-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl]-1,6-dihydropyridine-3-carboxamide
-
6-fluoro-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
6-phenyl-N-[3-(trifluoromethyl)benzyl]pyrimidin-4-amine
-
6-[(1-methyl-1H-pyrazol-5-yl)amino]-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
6-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]naphthalene-2-carboxylic acid
-
-
6-[3-(trifluoromethyl)phenyl]-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
-
7-(1H-indol-5-yl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
-
7-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
7-(trifluoromethyl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
-
7-(trifluoromethyl)-N-[5-(trifluoromethyl)pyridin-2-yl][1,2]oxazolo[5,4-c]pyridin-3-amine
-
7-(trifluoromethyl)-N-[6-(trifluoromethyl)pyridin-3-yl]-1,2-benzoxazol-3-amine
-
7-butyl-N-(2,3-dimethoxybenzyl)-6-(3,4,5-trimethoxyphenyl)-7H-cyclopenta[b]pyridine-3-carboxamide
-
7-[2-(trifluoromethyl)phenyl]-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
-
7-[3-(trifluoromethyl)phenyl]-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
-
9-hydroxy-10-(sulfooxy)octadecanoic acid
-
IC50 is 0.09 mM
9-[(pentylcarbamoyl)amino]non-4-ynoic acid
acetaldehyde/borohydride
-
13% inhibition at 1 mM at pH 7.4
Ag+
-
5 mM, more than 90% inhibition
alpha-hydroxyfarnesyl phosphonic acid
-
IC50 is 0.073 mM
alpha-sulfostearic acid
-
IC50 is above 0.1 mM
AR9276
a potent, orally bioavailable, ans selective sEH inhibitor, pharmacokinetics and clearance, overview. Lowers the cholesterol levels a nd attenuates abdominal aortic aneurysm formation. It also reduces lesions in thew aortic arch and nonliganted right carotid artery, but has no effect on ligation-induced vascular remodeling in the carotid artery, overview
benzaldehyde/borohydride
-
16% inhibition at 1 mM at pH 7.4
benzil
-
inhibition of microsomal enzyme with cis-stilbene oxide, and of cytosolic enzyme forms cEHTSO and cEHCSO
benzo(a)pyrene
-
intratracheal instillation of benzo(a)pyrene significantly suppresses NF-kappaB translocation, sEH, thioredoxin reductase and catalase activities in lung tissue. Glycyrrhizic acid oral administration at 50 and 100 mg/kg body weight significantly shows protection of lung epithelium by suppression of caspases activities in lung tissue and reduction of total protein, total cells, elastase activity. Results indicate a strong correlation between amelioration of sEH and thioredoxin reductase activities, and NF-kappaB activation
benzyl phenylmetanethiosulfonate
-
complete inhibition at 1 mM at pH 7.4
benzyl phenylmethanethiosulfonate
-
94% inhibition at 1 mM at pH 7.4
butyl 12-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]dodecanoate
-
butyl 12-[[(adamantan-1-yl)carbamoyl]amino]dodecanoate
-
carbodiimide/glycine methyl ester
Ce3+
-
inhibition of Mg2+-dependent acrtivity
cis-1-adamantan-1-yl-3-(4-benzyloxycyclohexyl)urea
-
cis-1-adamantan-1-yl-3-[4-(2,6-dichlorobenzyloxy)cyclohexyl]-urea
-
cis-1-adamantan-1-yl-3-[4-(2,6-difluorobenzyloxy)cyclohexyl]-urea
-
cis-1-adamantan-1-yl-3-[4-(4-bromophenoxy)cyclohexyl]urea
-
cis-1-adamantan-1-yl-3-[4-(4-fluorophenoxy)cyclohexyl]-urea
-
cis-1-adamantan-1-yl-3-[4-(4-methoxyphenoxy)cyclohexyl]-urea
-
cis-1-adamantan-1-yl-3-[4-(4-nitrophenoxy)cyclohexyl]urea
-
cis-3-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
cis-4-(4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy)-benzoic acid
-
cis-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]benzoic acid
-
-
cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
cis-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]-benzoic acid
cis-limonene epoxide
-
weak
Cu+
-
inhibition of phosphatase activity and epoxide hydrolase activity
D-galactose 6-sulfate
-
IC50 is above 0.1 mM
dibenzyl phosphonate
-
IC50 is above 0.1 mM
diethyl 2,2,2-trifluoro-1-hydroxyethyl phosphonate
-
IC50 is above 0.1 mM
diethyl 4-methylbenzyl phosphonate
-
IC50 is above 0.1 mM
diethyl allyl phosphonate
-
IC50 is above 0.1 mM
diethyl benzoylphosphonate
-
IC50 is above 0.1 mM
diethyl cyclopropyl methylphosphonate
-
IC50 is above 0.1 mM
diethyl ethylthiomethyl phosphonate
-
IC50 is above 0.1 mM
diethyl trans-cinnamyl phosphonate
-
IC50 is above 0.1 mM
diethyl vinylphosphonate
-
IC50 is above 0.1 mM
diisopropyl fluorophosphate
-
16% inhibition at 1 mM at pH 7.4
dimethyl 2-oxoheptyl phosphonate
-
IC50 is above 0.1 mM
dioctyl phenyl phosphonate
-
IC50 is 0.092 mM
dodecyl phosphonic acid
-
IC50 is 0.040 mM
Estrone 3-sulfate
-
IC50 is above 0.1 mM
ethyl (E)-3-[N-((2-trifluoromethyl)benzyl)benzamide]-alpha-ethylcinnamate
-
ethyl (E)-3-[N-((2-trifluoromethyl)benzyl)benzamide]-alpha-ethylcinnamic acid
-
ethyl (E)-4-[N-((2-(trifluoromethyl)-benzyl)benzamide]-alpha-ethylcinnamate
-
ethyl 1-(2-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylate
-
-
ethyl 1-(3-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylate
-
-
ethyl 1-(4-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylate
-
-
ethyl 1-[2-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)benzyl]-1H-pyrrole-2-carboxylate
-
-
ethyl 1-[2-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylate
-
-
ethyl 1-[3-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylate
-
-
ethyl 1-[4-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)benzyl]-1H-pyrrole-2-carboxylate
-
-
ethyl 1-[4-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylate
-
-
ethyl 2-ethyl 3-[3-(N-((2-trifluoromethyl)benzyl)benzamide)]-propanoate
-
ethyl 2-ethyl 3-[4-(N-((2-trifluoromethyl)benzyl)benzamide)]propanoate
-
ethyl 2-ethyl 3-[4-(N-((4-chloro)benzyl)benzamide)]-propanoate
-
ethyl 2-ethyl 3-[4-(N-((4-fluoro)benzyl)benzamide)]-propanoate
-
ethyl 2-ethyl 3-[4-(N-((4-methoxy)benzyl)benzamide)]-propanoate
-
ethyl 2-ethyl 3-[4-(N-((4-phenoxy)benzyl)benzamide)]-propanoate
-
ethyl 2-ethyl 3-[4-(N-((4-trifluoromethoxy)benzyl)-benzamide)]propanoate
-
ethyl 2-ethyl 3-[4-(N-((4-trifluoromethyl)benzyl)benzamide)]-propanoate
-
ethyl 2-ethyl 3-[4-(N-(4-fluoro(2-trifluoromethyl)benzyl)-benzamide)]propanoate
-
ethyl 2-ethyl 3-[4-(N-(4-methoxy(2-trifluoromethyl)benzyl)-benzamide)]propanoate
-
ethyl 2-ethyl-3-[4-(N-((2-bromo)benzyl)benzamide)]-propanoate
-
ethyl 2-ethyl-3-[4-(N-((2-chloro)benzyl)benzamide)]-propanoate
-
ethyl 2-ethyl-3-[4-(N-((2-methyl)benzyl)benzamide)]-propanoate
-
ethyl 2-ethyl-3-[4-(N-((2-trifluoromethoxy)benzyl)-benzamide)]prop
-
ethyl 2-ethyl-3-[4-(N-benzylbenzamide)]propanoate
-
ethyl 2-methyl 3-[4-(N-((2-trifluoromethyl)benzyl)benzamide)]-propanoate
-
ethyl 2-phenyl 3-[4-(N-((2-trifluoromethyl)benzyl)benzamide)]-propanoate
-
ethyl 2-propyl 3-[4-(N-((2-trifluoromethyl)benzyl)benzamide)]-propanoate
-
ethyl 3-[4-(N-((2-trifluoromethyl)benzyl)benzamide)]-propanoate
-
geraniol derivatives
-
weak
-
glycidyl 4-nitrobenzoate
-
IC50 for the S-enantiomer is 0.14 mM, and for the R-enantiomer 0.51 mM
Isopropanol
-
hydration of trans-stilbene oxide
L-ascorbic acid 2-sulfate
-
IC50 is above 0.1 mM
methanol
-
hydration of trans-stilbene oxide
methyl 2-([4-[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]piperidin-1-yl]carbonyl)benzoate
-
methyl 2-hydroxy-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]benzoate
methyl 2-[(4-[[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]methyl]piperidin-1-yl)carbonyl]benzoate
-
methyl 3-([4-[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]piperidin-1-yl]carbonyl)benzoate
-
methyl 3-chloro-4-[([[6-(3,3,3-trifluoropropoxy)pyridin-3-yl]carbonyl]amino)methyl]benzenesulfinate
-
-
methyl 3-[(4-[[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]methyl]piperidin-1-yl)carbonyl]benzoate
-
methyl 3-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]propanoate
methyl 4-((1,2,3,4-tetrahydronaphthalene-2-carboxamido)methyl)benzoic acid
-
-
methyl 4-([4-[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]piperidin-1-yl]carbonyl)benzoate
-
methyl 4-([[(6-hydroxynaphthalen-2-yl)carbonyl]amino]methyl)benzoate
-
-
methyl 4-([[(6-methoxynaphthalen-2-yl)carbonyl]amino]methyl)benzoate
-
-
methyl 4-[(4-[[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]methyl]piperidin-1-yl)carbonyl]benzoate
-
methyl 4-[(6R,12aS)-2-[3-(1H-imidazol-1-yl)propyl]-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-6-yl]benzoate
-
methyl 4-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]benzoate
-
-
methyl 4-[([[1-butyl-2-(3,4,5-trimethoxyphenyl)-1H-benzimidazol-5-yl]carbonyl]amino)methyl]-3-methoxybenzenesulfinate
-
-
methyl 4-[[(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)amino]methyl]benzoate
-
methyl 4-[[4-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)piperidin-1-yl]carbonyl]benzoate
-
-
methyl 5-oxo-5-(4-[[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]methyl]piperidin-1-yl)pentanoate
-
methyl 5-oxo-5-[4-[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]piperidin-1-yl]pentanoate
-
methyl 6-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]naphthalene-2-carboxylate
-
-
methyl methanethiosulfonate
methyl N-(cyclohexylcarbamoyl)glycinate
-
N'-(2-chlorophenyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carbohydrazide
-
62% inhibition at 200 nM
N'-(4-fluorophenyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carbohydrazide
-
9% inhibition at 200 nM
N'-phenyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carbohydrazide
-
16% inhibition at 200 nM
N'-[2-(3-chlorophenyl)ethyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carbohydrazide
-
65% inhibition at 200 nM
N,5-dibenzyl-1,3,4-oxadiazol-2-amine
-
N,N'-(butane-1,4-diyl)bis[4-(adamantan-2-yl)piperazine-1-carboxamide]
N,N'-1,2-phenylenebis[N'-(3-chloroadamantan-1-yl)urea]
N,N'-1,2-phenylenebis[N'-[(adamantan-1-yl)methyl]urea]
N,N'-1,4-phenylenebis[N'-[(adamantan-1-yl)methyl]urea]
N,N'-bis(3,5,7-trimethyladamantan-1-yl)urea
N,N'-bis(3,5-dimethyladamantan-1-yl)urea
N,N'-bis(3-chloroadamantan-1-yl)urea
N,N'-bis(3-ethyladamantan-1-yl)urea
N,N'-bis(3-methyladamantan-1-yl)urea
N,N'-bis-(3,4-dichlorophenyl)urea
N,N'-bis[(adamantan-1-yl)methyl]urea
N,N'-butane-1,4-diylbis[N'-(3,5-dimethyladamantan-1-yl)urea]
N,N'-butane-1,4-diylbis[N'-(3-chloroadamantan-1-yl)urea]
N,N'-butane-1,4-diylbis[N'-(3-ethyladamantan-1-yl)urea]
N,N'-butane-1,4-diylbis[N'-[(3,5-dimethyladamantan-1-yl)methyl]urea]
N,N'-butane-1,4-diylbis[N'-[(adamantan-1-yl)methyl]urea]
N,N'-butane-1,4-diylbis[N'-[1-(adamantan-1-yl)-2-methylpropan-2-yl]urea]
N,N'-butane-1,4-diylbis[N'-[2-(adamantan-1-yl)-2-phenylethyl]urea]
N,N'-butane-1,4-diylbis[N'-[2-(adamantan-1-yl)ethyl]urea]
N,N'-butane-1,4-diylbis[N'-[2-(adamantan-1-yl)pentyl]urea]
N,N'-butane-1,4-diylbis[N'-[4-(adamantan-1-yl)phenyl]urea]
N,N'-decane-1,10-diylbis[N'-(3-chloroadamantan-1-yl)urea]
N,N'-dicyclohexyl urea
i.e. DCU
N,N'-dicyclohexylcarbodiimide
-
0.01 mM, complete inhibition
N,N'-ethane-1,2-diylbis[N'-(3-chloroadamantan-1-yl)urea]
N,N'-ethane-1,2-diylbis[N'-[(adamantan-1-yl)methyl]urea]
N,N'-heptane-1,7-diylbis[N'-(3-chloroadamantan-1-yl)urea]
N,N'-heptane-1,7-diylbis[N'-[(adamantan-1-yl)methyl]urea]
N,N'-hexane-1,6-diylbis(N'-[3-[(adamantan-1-yl)oxy]propyl]urea)
N,N'-hexane-1,6-diylbis[N'-(3-chloroadamantan-1-yl)urea]
N,N'-hexane-1,6-diylbis[N'-(3-ethyladamantan-1-yl)urea]
N,N'-hexane-1,6-diylbis[N'-[(3,5-dimethyladamantan-1-yl)methyl]urea]
N,N'-hexane-1,6-diylbis[N'-[1-(adamantan-1-yl)ethyl]urea]
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)-2-methylpropyl]urea]
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)-2-phenylethyl]urea]
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)butyl]urea]
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)ethyl]urea]
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)pentyl]urea]
N,N'-hexane-1,6-diylbis[N'-[4-(adamantan-1-yl)phenyl]urea]
N,N'-octane-1,8-diylbis(N'-[3-[(adamantan-1-yl)oxy]propyl]urea)
N,N'-octane-1,8-diylbis[N'-(3,5-dimethyladamantan-1-yl)urea]
N,N'-octane-1,8-diylbis[N'-(3-chloroadamantan-1-yl)urea]
N,N'-octane-1,8-diylbis[N'-[(3,5-dimethyladamantan-1-yl)methyl]urea]
N,N'-octane-1,8-diylbis[N'-[(adamantan-1-yl)methyl]urea]
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)-2-methylpropyl]urea]
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)-2-phenylethyl]urea]
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)ethyl]urea]
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)pentyl]urea]
N,N'-octane-1,8-diylbis[N'-[4-(adamantan-1-yl)phenyl]urea]
N,N'-pentane-1,5-diylbis[N'-(3-chloroadamantan-1-yl)urea]
N,N'-pentane-1,5-diylbis[N'-(3-ethyladamantan-1-yl)urea]
N,N'-pentane-1,5-diylbis[N'-[(adamantan-1-yl)methyl]urea]
N,N'-propane-1,3-diylbis[N'-(3-chloroadamantan-1-yl)urea]
N,N'-propane-1,3-diylbis[N'-(3-ethyladamantan-1-yl)urea]
N,N'-propane-1,3-diylbis[N'-[(adamantan-1-yl)methyl]urea]
N,N'-undecane-1,11-diylbis[N'-[(adamantan-1-yl)methyl]urea]
N,N'-[1,4-phenylenebis(methylene)]bis[N'-(3,5-dimethyladamantan-1-yl)urea]
N,N-Dimethyl formamide
-
hydration of trans-stilbene oxide
N-((1-acetylpiperidin-4-yl)methyl)-N'-(adamant-1-yl)urea
-
-
N-((4-bromo-2-[(trifluoromethyl)oxy]phenyl)-methyl)-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-4-piperidinecarboxamide
GSK2188931B
N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
79% inhibition at 200 nM
N-(1,2-benzoxazol-3-yl)-3-methyl-3-phenylpiperidine-1-carboxamide
N-(1,3-benzodioxol-5-yl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
-
N-(1-(2,2,2-trifluoroethanoyl)piperidin-4-yl)-N'-(adamant-1-yl)urea
-
-
N-(1-acetylpiperidin-4-yl)-2-(tricyclo[3.3.1.13,7]dec-1-yl)acetamide
N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl) urea
-
N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
N-(1-acetylpiperidin-4-yl)-N'-adamantan-1-ylurea
-
N-(1-tert-butoxyethenyl)-1,2,3,4-tetrahydroquinolin-3-amine
-
N-(1-tert-butoxypiperidin-4-yl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
88% inhibition at 200 nM
N-(1-trifluoroacetylpiperidin-4-yl)-N'-(adamant-1-yl) urea
-
N-(2,2-diphenyl-ethyl)-nicotinamide
N-(2,3-dihydro-1H-inden-1-yl)-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
N-(2,3-dihydro-1H-inden-1-yl)-4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
-
N-(2,3-dihydro-1H-inden-2-yl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
62% inhibition at 200 nM
N-(2,4-dichloro-6-methylbenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
95% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
N-(2,4-dichlorobenzyl)-1-(diphenylphosphanyl)piperidine-4-carboxamide
-
3% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-(methylsulfonyl)piperidine-4-carboxamide
-
45% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-(quinolin-5-ylsulfonyl)piperidine-4-carboxamide
-
34% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-(thiophen-2-ylcarbonyl)piperidine-4-carboxamide
-
16% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-([1-[(2,4,6-trimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)piperidine-4-carboxamide
-
31% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-[(1-methylethyl)sulfonyl]piperidine-4-carboxamide
-
13% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-[(2,4,6-tri-tert-butylphenyl)sulfonyl]piperidine-4-carboxamide
-
88% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-[(2,4,6-trimethylphenyl)carbonyl]piperidine-4-carboxamide
-
34% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
N-(2,4-dichlorobenzyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
97% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-[(2-fluorophenyl)sulfonyl]piperidine-4-carboxamide
-
66% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-[(2-nitrophenyl)carbonyl]piperidine-4-carboxamide
-
44% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-[(2-nitrophenyl)sulfonyl]piperidine-4-carboxamide
-
47% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-[(3-nitrophenyl)carbonyl]piperidine-4-carboxamide
-
18% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-[(3-nitrophenyl)sulfonyl]piperidine-4-carboxamide
-
21% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-[(4-fluoro-2-nitrophenyl)sulfonyl]piperidine-4-carboxamide
-
63% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
98% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-[(4-methyl-2-nitrophenyl)sulfonyl]piperidine-4-carboxamide
-
28% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-[(4-methylphenyl)sulfonyl]piperidine-4-carboxamide
-
15% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-[[2-(trifluoromethyl)phenyl]sulfonyl]piperidine-4-carboxamide
-
39% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-[[2-nitro-4-(trifluoromethyl)phenyl]sulfonyl]piperidine-4-carboxamide
-
37% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-[[3-([4-[(2,4-dichlorobenzyl)carbamoyl]piperidin-1-yl]carbonyl)phenyl]sulfonyl]piperidine-4-carboxamide
-
45% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-3-(hydroxymethyl)piperidine-1-carboxamide
-
N-(2,4-dichlorobenzyl)-3-methyl-3-phenylpiperidine-1-carboxamide
N-(2,4-dichlorobenzyl)-4-(4-fluorophenoxy)piperidine-1-carboxamide
N-(2,4-dichlorobenzyl)-4-(pyridin-2-yl)piperazine-1-carboxamide
-
N-(2,4-dichlorobenzyl)-4-(pyridin-2-ylmethyl)piperidine-1-carboxamide
-
N-(2,4-dichlorobenzyl)-4-(pyrimidin-2-yloxy)piperidine-1-carboxamide
-
N-(2,4-dichlorobenzyl)-4-hydroxy-4-phenylpiperidine-1-carboxamide
-
N-(2,4-dichlorobenzyl)-4-phenoxypiperidine-1-carboxamide
-
N-(2,4-dichlorobenzyl)-4-[(4-fluorophenyl)sulfonyl]piperidine-1-carboxamide
-
N-(2,4-dichlorobenzyl)-4-[2-(methylsulfonyl)phenoxy]piperidine-1-carboxamide
-
N-(2,4-dichlorobenzyl)-4-[3-(methylsulfonyl)phenoxy]piperidine-1-carboxamide
-
N-(2,4-dichlorobenzyl)-4-[4-(methylcarbamoyl)phenoxy]piperidine-1-carboxamide
-
N-(2,4-dichlorobenzyl)-4-[4-(methylsulfamoyl)phenoxy]piperidine-1-carboxamide
-
N-(2,4-dichlorobenzyl)-4-[4-(methylsulfonyl)phenoxy]piperidine-1-carboxamide
-
N-(2,4-dichlorobenzyl)-4-[4-(trifluoromethoxy)phenoxy]piperidine-1-carboxamide
-
N-(2,4-dichlorobenzyl)-4-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
-
N-(2,4-dichlorobenzyl)-4-[[(4-fluorophenyl)sulfonyl]amino]piperidine-1-carboxamide
-
N-(2,4-dichlorobenzyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
N-(2,4-dichlorobenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
N-(2,4-dichlorobenzyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
N-(2,4-difluorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
97% inhibition at 200 nM
N-(2,5-dichlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
98% inhibition at 200 nM
N-(2-bromophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
-
N-(2-chloro-4-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
N-(2-chloro-4-fluorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
98% inhibition at 200 nM
N-(2-chloro-6-fluorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
97% inhibition at 200 nM
N-(2-chlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
90% inhibition at 200 nM
N-(2-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
N-(2-chlorophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
-
N-(2-cyanobenzyl)-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
-
-
N-(2-methoxybenzyl)-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
-
-
N-(2-methylbenzyl)-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
-
-
N-(2-methylcyclohexyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
77% inhibition at 200 nM
N-(2-oxoadamantan-1-yl)-N'-1,3,5-triazatricyclo[3.3.1.13,7]decan-7-ylurea
N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide
N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
N-(2-phenylcyclopropyl)-4-(1H-1,2,4-triazol-1-yl)piperidine-1-carboxamide
-
N-(2-phenylcyclopropyl)-4-(1H-pyrazol-1-yl)piperidine-1-carboxamide
-
N-(2-phenylcyclopropyl)-4-[3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
-
N-(2-phenylcyclopropyl)-4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
-
N-(2-phenylcyclopropyl)-4-[3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
-
N-(2-phenylcyclopropyl)-4-[3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
-
N-(2-phenylcyclopropyl)-4-[3-(pyrimidin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
-
N-(2-phenylcyclopropyl)-4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
-
N-(2-phenylcyclopropyl)-4-[3-[2-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
-
N-(2-phenylethyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
67% inhibition at 200 nM
N-(3,3-diphenyl-propyl)-2-pyridine-3-ylacetamide
N-(3,3-diphenyl-propyl)-isonicotinamide
N-(3,3-diphenyl-propyl)-nicotinamide
N-(3,3-diphenylpropyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
N-(3,3-diphenylpropyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
78% inhibition at 200 nM
N-(3,3-diphenylpropyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
N-(3,3-diphenylpropyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
N-(3,3-diphenylpropyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
N-(3,4-dichlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
97% inhibition at 200 nM
N-(3,4-dichlorobenzyl)-3-(hydroxymethyl)piperidine-1-carboxamide
-
N-(3,4-dichlorophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
-
N-(3,5,7-trimethyladamantan-1-yl)-4-([[(3,5,7-trimethyladamantan-1-yl)carbamoyl]amino]methyl)piperidine-1-carboxamide
N-(3,5-dichlorophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
-
N-(3,5-dimethyladamantan-1-yl)-N'-(1-propanoylpiperidin-4-yl)urea
N-(3,5-dimethyladamantan-1-yl)-N'-(3,5,7-trimethyladamantan-1-yl)urea
N-(3,5-dimethyladamantan-1-yl)-N'-1,3,5-triazatricyclo[3.3.1.13,7]decan-7-ylurea
N-(3,5-dimethyladamantan-1-yl)-N'-[(3-ethyladamantan-1-yl)methyl]urea
N-(3,5-dimethyladamantan-1-yl)-N'-[4-([[(3,5-dimethyladamantan-1-yl)carbamoyl]amino]methyl)phenyl]urea
N-(3-(4-chlorophenyl)-3-phenylpropyl)-3-(3-(1-hydroxyureido)-but-1-yn-1-yl)benzamide
-
dual 5-LOX/soluble epoxide hydrolase inhibitor
-
N-(3-ethyladamantan-1-yl)-N'-(1-propanoylpiperidin-4-yl)urea
N-(3-ethyladamantan-1-yl)-N'-1,3,5-triazatricyclo[3.3.1.13,7]decan-7-ylurea
-
N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-2-(tricyclo[3.3.1.13,7]dec-1-yl)acetamide
N-(3-methylbutyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
87% inhibition at 200 nM
N-(3-methylphenyl)-4-[[1-methyl-5-(pyrrolidine-1-carbonyl)-1H-benzimidazol-2-yl]methyl]piperazine-1-carboxamide
-
N-(3-phenyl-propyl)-nicotinamide
N-(4,4-diphenyl-butyl)-nicotinamide
N-(4-(N1-methyl-N2-methyl-N2-(methyloxy)oxalamido)-benzyl)adamantanecarboxamide
-
N-(4-(N2-(tetrahydro-2H-pyran-2-yloxy)oxalamido)benzyl)adamantanecarboxamide
-
N-(4-(N2-methyl-N2-(methyloxy)oxalamido)benzyl)adamantanecarboxamide
-
N-(4-(N2-methyloxyoxalamido)benzyl)adamantanecarboxamide
-
N-(4-(N2-tert-butyloxyoxalamido)benzyl)adamantanecarboxamide
-
N-(4-bromo-2-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
N-(4-bromophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
-
N-(4-chlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
97% inhibition at 200 nM
N-(4-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
N-(4-chloronaphthalen-1-yl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
44% inhibition at 200 nM
N-(4-chlorophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
-
N-(4-chlorophenyl)-3-(2-cyanoethyl)-3-phenylpiperidine-1-carboxamide
N-(4-chlorophenyl)-3-(2-hydroxyethyl)-3-phenylpiperidine-1-carboxamide
N-(4-chlorophenyl)-3-(3-hydroxypropyl)-3-phenylpiperidine-1-carboxamide
N-(4-chlorophenyl)-3-methyl-3-phenylpiperidine-1-carboxamide
N-(4-chlorophenyl)-3-phenyl-3-[2-(1H-tetrazol-5-yl)ethyl]piperidine-1-carboxamide
N-(4-chlorophenyl)-3-[2-(dimethylamino)ethyl]-3-phenylpiperidine-1-carboxamide
N-(4-chlorophenyl)-3-[2-oxo-2-(1H-tetrazol-5-ylamino)ethyl]-3-phenylpiperidine-1-carboxamide
N-(4-chlorophenyl)-3-[3-(diethylamino)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide
N-(4-chlorophenyl)-3-[3-(methylamino)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide
N-(4-chlorophenyl)-3-[3-(morpholin-4-yl)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide
N-(4-chlorophenyl)-3-[3-oxo-3-(1H-tetrazol-5-ylamino)propyl]-3-phenylpiperidine-1-carboxamide
N-(4-chlorophenyl)-5-(methylsulfonyl)-2,3-dihydro-1H-indole-1-carboxamide
-
N-(4-chlorophenyl)piperidine-1-carboxamide
-
N-(4-methylcyclohexyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
86% inhibition at 200 nM
N-(4-[(3-phenyloxiran-2-yl)carbonyl]phenyl)acetamide
N-(4-[[(adamantan-1-yl)carbamoyl]amino]butyl)-N'-(3,5-dimethyladamantan-1-yl)urea
-
N-(5-chloro-1,3-benzoxazol-2-yl)-2-cyclopentylacetamide
-
N-(6-[[(adamantan-1-yl)carbamoyl]amino]hexyl)-N'-(3,5-dimethyladamantan-1-yl)urea
-
N-(8-[[(adamantan-1-yl)carbamoyl]amino]octyl)-N'-(3,5-dimethyladamantan-1-yl)urea
-
N-(benzyloxy)-2-(adamant-2-ylamino)acetamide
-
N-(biphenyl-3-yl)-1,2-benzoxazol-3-amine
-
N-(biphenyl-3-yl)-3-methyl-3-phenylpiperidine-1-carboxamide
N-(biphenyl-4-yl)-1,2-benzoxazol-3-amine
-
N-(cyclohexylcarbamoyl)glycine
binding structure analysis
N-(cyclohexylmethyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
92% inhibition at 200 nM
N-(cyclohexylmethyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
-
N-(naphthalen-1-yl)-1,2-benzoxazol-3-amine
-
N-(naphthalen-1-ylmethyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
55% inhibition at 200 nM
N-(naphthalen-2-yl)-1,2-benzoxazol-3-amine
-
N-(pyridin-3-ylmethyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
23% inhibition at 200 nM
N-(pyridin-4-ylmethyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
49% inhibition at 200 nM
N-([1-(phenylcarbonyl)piperidin-4-yl]methyl)-N'-(adamant-1-yl) urea
-
N-([1-(trifluoroacetyl)piperidin-4-yl]methyl)-N'-(adamant-1-yl) urea
-
N-acetyl imidazole
-
12% inhibition at 1 mM at pH 7.4
N-acetyl-D-galactosamine 4-sulfate
-
IC50 is above 0.1 mM
N-adamantan-1-yl-N'-(3,5,7-trimethyladamantan-1-yl)urea
N-adamantan-1-yl-N'-(3,5-dimethyladamantan-1-yl)urea
N-adamantan-1-yl-N'-(5-hydroxypentyl)urea
N-adamantan-1-yl-N'-(5-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]pentyl)urea
N-adamantan-1-yl-N'-[(3-ethyladamantan-1-yl)methyl]urea
N-adamantan-1-yl-N'-[5-(2-hydroxyethoxy)pentyl]urea
N-adamantan-1-yl-N'-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]urea
N-adamantan-1-yl-N'-[5-[2-(2-hydroxyethoxy)ethoxy]pentyl]urea
N-adamantanyl-N'-dodecanoic acid urea
-
N-adamantyl-N'-cyclohexylurea
N-benzyl-1,3-benzothiazol-2-amine
-
N-benzyl-1,3-benzoxazol-2-amine
-
N-benzyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
65% inhibition at 200 nM
N-benzyl-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
-
-
N-benzyl-3-(hydroxymethyl)piperidine-1-carboxamide
-
N-benzyl-4-phenylpyridin-2-amine
-
N-benzyl-5-phenyl-1,3,4-oxadiazol-2-amine
-
N-benzyl-5-phenylpyrazin-2-amine
-
N-benzyl-5-phenylpyridin-2-amine
-
N-benzyl-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
N-benzylquinoxalin-2-amine
-
N-benzyltricyclo[3.3.1.13,7]decane-1-carboxamide
-
N-bromosuccimide
-
98% inhibition at 1 mM at pH 7.4
N-cyclobutyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
-
N-cycloheptyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
N-cycloheptyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
-
N-cyclohexyl(dodecylamino)carboxamide
-
N-cyclohexyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
87% inhibition at 200 nM
N-cyclohexyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
-
N-cyclohexyl-N'-(3-phenyl)propyl urea
-
N-cyclohexyl-N'-(3-phenyl)propylurea
-
N-cyclohexyl-N'-(4-iodophenyl)urea
CIU
N-cyclohexyl-N'-(iodophenyl)urea
binding structure at the C-terminus
N-cyclohexyl-N'-4-chlorophenylurea
N-cyclohexyl-N'-decylurea
N-cyclohexyl-N'-dodecylurea
-
weak inhibition
N-cyclohexyl-N'-ethylurea
-
N-cyclohexyl-N'-iodophenyl urea
binding structure analysis
N-cyclooctyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
-
N-cyclopentyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
75% inhibition at 200 nM
N-cyclopentyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
-
N-cyclopentyl-N'-dodecylurea
N-cyclopropyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
-
N-methoxy-N-methyl 3-[4-(N-((2-trifluoromethyl)benzyl)-benzamide)]cyclopropanecarboxamide
-
N-methyl-1-[3-(pyridin-3-yl)phenyl]methanamine
-
N-methyl-4-([4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]cyclohexyl]oxy)benzamide
-
-
N-methyl-4-[[4-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)cyclohexyl]oxy]benzamide
-
-
N-morpholin-4-yl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
14% inhibition at 200 nM
N-naphthalen-1-yl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
50% inhibition at 200 nM
N-phenyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
48% inhibition at 200 nM
N-phenyl-5-(trifluoromethyl)-1,3,4-oxadiazol-2-amine
-
N-piperidin-1-yl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
55% inhibition at 200 nM
N-piperidin-4-yl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
15% inhibition at 200 nM
N-tert-butyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
3% inhibition at 200 nM
N-[(1-methyl-1H-pyrazol-3-yl)methyl]-2-phenylethan-1-amine
-
N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-4-methylpiperazine-1-carboxamide
N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]piperidine-1-carboxamide
N-[(3'-chlorobiphenyl-4-yl)methyl]-3-methyl-3-phenylpiperidine-1-carboxamide
N-[(3,5-dimethyladamantan-1-yl)methyl]-N'-(3,5,7-trimethyladamantan-1-yl)urea
N-[(3-chloro-4'-fluorobiphenyl-4-yl)methyl]-6-[3-(trifluoromethoxy)phenoxy]pyridine-3-carboxamide
-
N-[(3-ethyladamantan-1-yl)methyl]-N'-(1-propanoylpiperidin-4-yl)urea
N-[(3-ethyladamantan-1-yl)methyl]-N'-1,3,5-triazatricyclo[3.3.1.13,7]decan-7-ylurea
N-[(4-chlorophenyl)(phenyl)methyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
7% inhibition at 200 nM
N-[(adamantan-1-yl)carbamoyl]-beta-alanine
N-[(adamantan-1-yl)methyl]-2-[3-(adamantan-1-yl)propyl]hydrazine-1-carboxamide
N-[(adamantan-1-yl)methyl]-4-[([[(adamantan-1-yl)methyl]carbamoyl]amino)methyl]piperidine-1-carboxamide
N-[(adamantan-1-yl)methyl]-N'-(1-propanoylpiperidin-4-yl)urea
N-[(adamantan-1-yl)methyl]-N'-[2-(adamantan-1-yl)pentyl]urea
N-[(adamantan-1-yl)methyl]-N'-[4-(adamantan-1-yl)phenyl]urea
N-[1-(1-oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]-urea
-
-
N-[1-(1-oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]urea
-
N-[1-(1-oxopropyl)-4-piperidinyl]-N0-[4-(trifluoromethoxy)phenyl]-urea
TPPU
N-[1-(4-chlorophenyl)ethyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
94% inhibition at 200 nM
N-[1-(adamantan-1-yl)ethyl]-N'-(3,5,7-trimethyladamantan-1-yl)urea
N-[1-(adamantan-1-yl)ethyl]-N'-[(3-ethyladamantan-1-yl)methyl]urea
N-[1-(phenylcarbonyl)piperidin-4-yl]-N'-(adamant-1-yl) urea
-
N-[1-(pyridin-2-ylcarbonyl)piperidin-4-yl]-N'-(adamant-1-yl) urea
-
N-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-2-[4-(trifluoromethoxy)phenyl]acetamide
N-[2-(4-methoxyphenyl)ethyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
44% inhibition at 200 nM
N-[2-(adamantan-1-yl)butyl]-N'-(3,5,7-trimethyladamantan-1-yl)urea
N-[2-(adamantan-1-yl)butyl]-N'-(3,5-dimethyladamantan-1-yl)urea
N-[2-(adamantan-1-yl)ethyl]-N'-[(adamantan-1-yl)methyl]urea
N-[2-(adamantan-1-yl)pentyl]-N'-(3-chloroadamantan-1-yl)urea
N-[2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
N-[2-(morpholin-4-yl)phenyl]thiophene-3-carboxamide
-
N-[2-(trifluoromethoxy)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
N-[2-(trifluoromethoxy)phenyl]-1,2-benzoxazol-3-amine
-
N-[2-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
-
N-[2-chloro-4-(1H-tetrazol-5-yl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
N-[2-chloro-4-(methylsulfamoyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
N-[2-chloro-4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
N-[2-chloro-5-(trifluoromethyl)benzyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
94% inhibition at 200 nM
N-[2-[4-(benzyloxy)phenyl]ethyl]-2-hydroxy-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
-
-
N-[2-[4-(benzyloxy)phenyl]ethyl]-2-hydroxy-4-(tricyclo[3.3.1.13,7]dec-1-yl)butanamide
-
N-[2-[4-(benzyloxy)phenyl]ethyl]-2-hydroxy-4-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]butanamide
-
-
N-[2-[4-(benzyloxy)phenyl]ethyl]-2-oxo-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
-
-
N-[2-[4-(benzyloxy)phenyl]ethyl]-2-oxo-4-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]butanamide
-
-
N-[3,3-bis-(4-fluorophenyl)-propyl]-2-(2,2,2-trifluoro-ethoxy)-isonicotinamide
N-[3,3-bis-(4-fluorophenyl)-propyl]-4-methanesulfonyl-benzamide
N-[3,3-bis-(4-fluorophenyl)-propyl]-6-(2,2,2-trifluoro-ethoxy)-nicotinamide
N-[3,3-bis-(4-fluorophenyl)-propyl]-6-hydroxy-nicotinamide
N-[3,3-bis-(4-fluorophenyl)-propyl]-benzamide
N-[3,3-bis-(4-fluorophenyl)-propyl]-nicotinamide
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-oxo-2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]acetamide
-
-
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-oxo-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
-
-
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-oxo-4-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]butanamide
-
-
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-[4-(trifluoromethyl)phenyl]acetamide
-
-
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-4-(trifluoromethyl)benzamide
-
-
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-4-(trifluoromethyl)benzenesulfonamide
-
-
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-N'-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]sulfamide
-
-
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-N-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-ylmethyl]formamide
-
-
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-N-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]formamide
-
-
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-N2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]glycinamide
-
-
N-[3-(3-morpholin-4-ylpropoxy)phenyl]cyclohexanecarboxamide
-
-
N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-4-methanesulfonyl-benzamide
N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-(2,2,2-trifluoro-ethoxy)-nicotinamide
N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-nicotinamide
N-[3-(trifluoromethoxy)phenyl]-1,2-benzoxazol-3-amine
-
N-[3-carbamoyl-4-(piperidin-1-yl)phenyl]-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
-
N-[3-[(2',4'-difluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide
-
N-[3-[2-(4-chlorophenyl)ethyl]benzyl]-3-methyl-3-phenylpiperidine-1-carboxamide
N-[4-(1H-indol-5-yl)benzyl]-3-methyl-3-phenylpiperidine-1-carboxamide
N-[4-(2-methylpropanoyl)cyclohexyl]-N'-[4-(trifluoromethyl)phenyl]urea
i.e. UC2389
N-[4-(3-benzoyloxiran-2-yl)phenyl]acetamide
N-[4-(4-methoxyphenoxy)cyclohexyl]-N'-(tricyclo[3.3.1.13,7]dec-1-yl)methanediamine
-
-
N-[4-(benzyloxy)phenyl]-2-hydroxy-2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]acetamide
-
-
N-[4-(benzyloxy)phenyl]-2-hydroxy-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
-
-
N-[4-(benzyloxy)phenyl]-2-oxo-2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]acetamide
-
-
N-[4-(benzyloxy)phenyl]-2-oxo-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
-
-
N-[4-(butan-2-yl)phenyl]-3H-indole-3-carboxamide
-
N-[4-(butan-2-yl)phenyl]-5-methyl-1,2-oxazole-4-carboxamide
-
N-[4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
N-[4-(trifluoromethoxy)phenyl]-1,2-benzoxazol-3-amine
-
N-[4-(trifluoromethoxy)phenyl]-1,4'-bipiperidine-1'-carboxamide
-
N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
-
N-[4-(trifluoromethyl)benzyl]-1,2-benzoxazol-3-amine
-
N-[4-(trifluoromethyl)phenyl]-1,2-benzothiazol-3-amine
-
N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
-
N-[4-(trifluoromethyl)phenyl]-1H-indazol-3-amine
-
N-[4-(trifluoromethyl)phenyl][1,2]oxazolo[4,5-b]pyridin-3-amine
-
N-[4-(trifluoromethyl)phenyl][1,2]oxazolo[5,4-b]pyridin-3-amine
-
N-[4-(trifluoromethyl)phenyl][1,2]oxazolo[5,4-c]pyridin-3-amine
-
N-[4-([[(adamantan-1-yl)methyl]carbamoyl]amino)butyl]-N'-[(3,5-dimethyladamantan-1-yl)methyl]urea
-
N-[4-([[(adamantan-1-yl)methyl]carbamoyl]amino)phenyl]-N'-[(3,5-dimethyladamantan-1-yl)methyl]urea
-
N-[4-bromo-2-(trifluoromethoxy)benzyl]-6-(4-fluorophenyl)pyridine-3-carboxamide
-
N-[4-chloro-2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
N-[4-chloro-3-(trifluoromethyl)benzyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
96% inhibition at 200 nM
N-[4-chloro-3-(trifluoromethyl)phenyl]-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
-
N-[4-fluoro-2-(trifluoromethyl)benzyl]-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
-
-
N-[4-[(4-chlorophenyl)sulfonyl]cyclohexyl]-2-hydroxy-2-(tricyclo[3.3.1.13,7]dec-1-yl)acetamide
-
N-[4-[3-(morpholin-4-yl)propoxy]phenyl]-N'-[4-(trifluoromethyl)phenyl]urea
-
-
N-[4-[3-(pyridin-3-yl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]benzyl]pyridine-3-carboxamide
-
N-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-N'-(4-hydroxyadamantan-1-yl)urea
N-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-N'-(4-oxoadamantan-1-yl)urea
N-[6-([[(adamantan-1-yl)methyl]carbamoyl]amino)hexyl]-N'-[(3,5-dimethyladamantan-1-yl)methyl]urea
-
N-[8-([[(adamantan-1-yl)methyl]carbamoyl]amino)octyl]-N'-[(3,5-dimethyladamantan-1-yl)methyl]urea
-
N-[[2-chloro-4-(methanesulfonyl)phenyl]methyl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
-
-
N-[[4'-(methylsulfonyl)biphenyl-4-yl]methyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
N-[[4-([[4-(trifluoromethyl)phenyl]carbamoyl]amino)phenyl]sulfonyl]-b-alanine
-
N1,N4-bis[(adamantan-1-yl)methyl]piperazine-1,4-dicarboxamide
N1-(2,4-dichlorobenzyl)-N4-(2-methoxyethyl)piperidine-1,4-dicarboxamide
N1-(2,4-dichlorobenzyl)-N4-(tetrahydro-2H-pyran-4-yl)piperidine-1,4-dicarboxamide
-
N1-(2,4-dichlorobenzyl)-N4-[2-(methylsulfonyl)ethyl]piperidine-1,4-dicarboxamide
-
N1-(2,4-dichlorobenzyl)-N4-[2-(pyrrolidin-1-yl)ethyl]piperidine-1,4-dicarboxamide
-
N1-(2,4-dichlorobenzyl)-N4-[2-(tetrahydro-2H-pyran-4-yl)ethyl]piperidine-1,4-dicarboxamide
-
N1-(2,4-dichlorobenzyl)piperidine-1,4-dicarboxamide
-
N1-(4-((2-adamantylacetamido)methyl)phenyl)-N1-methyl-N2-methyl-N2-methyloxyoxalamide
-
N1-(4-((2-adamantylacetamido)methyl)phenyl)-N2-methyl-N2-methyloxyoxalamide
-
N1-(4-(2-adamantylacetamido)phenyl)-N1-methyl-N2-methyl-N2-(methyloxy)oxalamide
-
N1-(4-(2-adamantylacetamido)phenyl)-N2-methyl-N2-(methyloxy)oxalamide
-
N1-(adamant-1-yl)-N2-(benzyloxy)oxalamide
-
N1-(adamant-1-ylmethyl)-N2-(benzyloxy)oxalamide
-
N1-(adamant-2-yl)-N2-(2-phenylethyloxy)oxalamide
-
N1-(adamant-2-yl)-N2-(3-phenylpropyloxy)oxalamide
-
N1-(adamant-2-yl)-N2-(4-chlorobenzyloxy)oxalamide
-
N1-(adamant-2-yl)-N2-(4-methoxycarbonylbenzyloxy)oxalamide
-
N1-(adamant-2-yl)-N2-(4-nitrobenzyloxy)oxalamide
-
N1-(adamant-2-yl)-N2-(benzyloxy)-N2-methyloxalamide
-
N1-(adamant-2-yl)-N2-(benzyloxy)oxalamide
-
N1-(adamant-2-yl)-N2-(phenyloxy)oxalamide
-
N1-(adamant-2-yl)-N2-(tetrahydro-2H-pyran-2-yloxy)oxalamide
-
N1-(adamant-2-yl)-N2-methyl-N2-(methyloxy)oxalamide
-
N1-(adamantan-1-yl)-N2-(benzyloxy)ethanediamide
-
-
N1-(benzyloxy)-N2-(3-phenylpropyl)oxalamide
-
octadecan-9-yl sulfate
-
IC50 is 0.021 mM
okadaic acid
-
12% inhibition at 0.1 mM
omega-bromo-4-nitroacetophenone
-
-
omega-bromo-nitro-acetophenone
-
-
p-hydroxymercuribenzoate
-
-
p-Hydroxymercuriphenylsulfonate
phenyl(3-phenyloxiran-2-yl)methanol
phenyl(3-phenyloxiran-2-yl)methanone
phenyl-1,2-ethanediol
product inhibition, 50% inhibition at 50 mM
PMSF
-
27% inhibition at 1 mM at pH 7.4
pyridine-2-carboxylic acid (3,3-diphenyl-propyl)-amide
pyridine-3-sulfonic acid 3,3-(diphenylpropyl)-amide
quercetin
-
1 mM, 75% inhibition
racemic 2,3-epoxy-1,3-diphenyl-1-propanol
-
IC50 is 0.029 mM
racemic 2,3-epoxy-3-(4-fluorophenyl)-1-phenyl-1-propanol
-
IC50 is 0.032 mM
racemic 2,3-epoxy-3-(4-nitrophenyl)-1-phenyl-1-propanol
-
IC50 is 0.0017 mM
racemic 3,4-epoxy-4-(4-nitrophenyl)-1-butanol
-
IC50 is 0.012 mM
racemic 3-(4-nitrophenyl)glycidol
-
IC50 is 0.005 mM
Sodium dodecyl sulfate
-
IC50 is above 0.1 mM
sodium dodecyl sulfonate
-
IC50 is 0.05 mM
sodium orthovanadate
-
9% inhibition at 0.1 mM
sorafenib
-
a vascular endothelial growth factor receptor, inhibits sEH, effects in vivo, causes a shift in oxylipid profile and reduces the acute inflammatory response, overview. Reverses lipopolysaccharide-induced hypotension
substituted chalcone oxides
-
t-butyl 4-[2-[(5-chloro-1,3-benzoxazol-2-yl)amino]-2-oxoethyl]piperidine-1-carboxylate
IC50 value in COS-7 cell assay 1.5 nM, 43% remiaining stability in human microsomes
taurocholic acid
-
IC50 is 0.09 mM
taurolithocholic acid 3-sulfate
-
IC50 is above 0.1 mM
tert-butyl 4-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]piperidine-1-carboxylate
-
-
tetraisopropyl methylenediphosphonate
-
IC50 is above 0.1 mM
trans-(2R,3R)-3-phenylglycidol
trans-(2S,3S)-3-phenylglycidol
trans-1-adamantan-1-yl-3-(4-benzyloxycyclohexyl)urea
-
trans-1-adamantan-1-yl-3-[4-(2,6-dichlorobenzyloxy)cyclohexyl]-urea
-
trans-1-adamantan-1-yl-3-[4-(2,6-difluorobenzyloxy)cyclohexyl]-urea
-
trans-1-adamantan-1-yl-3-[4-(2-methylbenzyloxy)cyclohexyl]-urea
-
trans-1-adamantan-1-yl-3-[4-(3,5-difluorophenoxy)cyclohexyl]-urea
-
trans-1-adamantan-1-yl-3-[4-(4-bromobenzyloxy)cyclohexyl]-urea
-
trans-1-phenylpropylene oxide
-
IC50 for the S-enantiomer is 3.47 mM, and for the R-enantiomer 2.98 mM
trans-2-methyl-3-phenylglycidol
-
IC50 for the S-enantiomer is 1.52 mM, and for the R-enantiomer 2.0 mM
trans-3-(4-bromophenyl)glycidol
-
IC50 for the S-enantiomer is 0.12 mM, and for the R-enantiomer 0.77 mM
trans-3-(4-nitrophenyl)glycidol
-
IC50 for the S-enantiomer is 0.013 mM, and for the R-enantiomer 4.24 mM
trans-3-(4-nitrophenyl)glycidyl acetate
-
IC50 for the S-enantiomer is 0.232 mM, and for the R-enantiomer 0.39 mM
trans-3-(4-nitrophenyl)glycidyl benzoate
-
IC50 for the S-enantiomer is 0.229 mM, and for the R-enantiomer 0.10 mM
trans-3-methylglycidyl 4-nitrobenzoate
-
the S-enantiomer shows 20% inhibition at 0.8 mM, the R-enantiomer 16.5% inhibition at 0.8 mM
trans-4-((4-(3-adamantylureido)-cyclohexyl)oxy)-benzoic acid
-
-
trans-4-(4-(3-adamantan-1-yl-ureido)-cyclohexyloxy)-benzoic acid
trans-4-(4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy)benzoic acid
-
trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid
trans-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]-benzoic acid
-
-
trans-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
trans-4-[4-(3-adamantan-1-ylureido)-cyclohexyloxy]-benzoic acid
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]-benzoic acid
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
trans-4-[4-[3-(4-trifluoromethoxyphenyl)-ureido]-cyclohexyloxy]benzoic acid
trans-4-{4-[3-(4-trifluoromethoxyphenyl)-ureido]cyclohexyloxy}benzoic acid
-
-
trans-4[4-(3-adamantanyl-1-yl-ureido)cyclohexyloxy]-benzoic acid
i.e.tAUCB
trans-9,10-epoxystearate
-
1 mM, 20% inhibition of hydration of 0.025 mM cis-9,10-epoxystearate
trans-limonene epoxide
-
weak
trans-stilbene oxide
-
inhibits hydration of trans-9,10-epoxystearate
trichloropropylene oxide
-
-
[(5-[[(adamantan-1-yl)carbamoyl]amino]pentyl)oxy]acetic acid
[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]acetic acid
[2-[(5-[[(adamantan-1-yl)carbamoyl]amino]pentyl)oxy]ethoxy]acetic acid
[3-(2-naphthyl)oxiran-2-yl](4-nitrophenyl)methanone
[3-(2-naphthyl)oxiran-2-yl](phenyl)methanol
[3-(2-naphthyl)oxiran-2-yl](phenyl)methanone
[3-(4-bromophenyl)oxiran-2-yl](phenyl)methanone
[3-(4-butylphenyl)oxiran-2-yl](phenyl)methanone
[3-(4-fluorophenyl)oxiran-2-yl](phenyl)methanol
[3-(4-fluorophenyl)oxiran-2-yl](phenyl)methanone
[3-(4-heptylphenyl)oxiran-2-yl](phenyl)methanone
[3-(4-isopropylphenyl)oxiran-2-yl](phenyl)methanone
[3-(4-methoxyphenyl)oxiran-2-yl](phenyl)methanone
[3-(4-methylphenyl)oxiran-2-yl](phenyl)methanone
[3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanol
[3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanone
[3-(4-phenoxycyclohexa-1,5-dien-1-yl)oxiran-2-yl](phenyl)methanone
[4-(allyloxy)phenyl](3-phenyloxiran-2-yl)methanone
[4-(bromomethyl)phenyl][3-(2-naphthyl)oxiran-2-yl]methanone
[6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl][4-(trifluoromethyl)phenyl]methanone
[N-(2-(trifluoromethyl)benzyl)benzamide]-4-(1H-tetrazole)
-
(3-[4-(allyloxy)phenyl]oxiran-2-yl)(phenyl)methanone
-
IC50 is 0.00029 mM
(3-[4-(allyloxy)phenyl]oxiran-2-yl)(phenyl)methanone
-
IC50 is 0.0021 mM
(3-[4-(benzyloxy)phenyl]oxiran-2-yl)(phenyl)methanone
-
IC50 is 0.00023 mM
(3-[4-(benzyloxy)phenyl]oxiran-2-yl)(phenyl)methanone
-
IC50 is 0.00028 mM
(3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(4-fluorobenzene-1-sulfonyl)amino]piperidine-1-carboxamide
-
(3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(4-fluorobenzene-1-sulfonyl)amino]piperidine-1-carboxamide
-
(3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(methanesulfonyl)amino]piperidine-1-carboxamide
-
(3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(methanesulfonyl)amino]piperidine-1-carboxamide
-
(4-bromophenyl)(3-phenyloxiran-2-yl)methanone
-
IC50 is 0.00022 mM
(4-bromophenyl)(3-phenyloxiran-2-yl)methanone
-
IC50 is 0.0006 mM
(4-bromophenyl)[3-(2-naphthyl)oxiran-2-yl]methanone
-
IC50 is 0.00018 mM
(4-bromophenyl)[3-(2-naphthyl)oxiran-2-yl]methanone
-
IC50 is 0.00014 mM
(4-fluorophenyl)(3-phenyloxiran-2-yl)methanone
-
IC50 is 0.00039 mM
(4-fluorophenyl)(3-phenyloxiran-2-yl)methanone
-
IC50 is 0.0018 mM
(4-iodophenyl)(3-phenyloxiran-2-yl)methanone
-
IC50 is 0.00042 mM
(4-iodophenyl)(3-phenyloxiran-2-yl)methanone
-
IC50 is 0.0014 mM
(4-methoxyphenyl)(3-phenyloxiran-2-yl)methanone
-
IC50 is 0.00020 mM
(4-methoxyphenyl)(3-phenyloxiran-2-yl)methanone
-
IC50 is 0.00032 mM
(4-methylphenyl)(3-phenyloxiran-2-yl)methanone
-
IC50 is 0.00023 mM
(4-methylphenyl)(3-phenyloxiran-2-yl)methanone
-
IC50 is 0.0017 mM
(4-methylphenyl)[3-(2-naphthyl)oxiran-2-yl]methanol
-
IC50 is 0.00015 mM
(4-methylphenyl)[3-(2-naphthyl)oxiran-2-yl]methanol
-
IC50 is 0.00009 mM
(4-methylphenyl)[3-(2-naphthyl)oxiran-2-yl]methanone
-
IC50 is 0.00019 mM
(4-methylphenyl)[3-(2-naphthyl)oxiran-2-yl]methanone
-
IC50 is 0.00010 mM
(4-nitrophenyl)(3-phenyloxiran-2-yl)methanone
-
IC50 is 0.00025 mM
(4-nitrophenyl)(3-phenyloxiran-2-yl)methanone
-
IC50 is 0.0015 mM
(4Z)-9-[(pentylcarbamoyl)amino]non-4-enoic acid
-
-
(4Z)-9-[(pentylcarbamoyl)amino]non-4-enoic acid
-
(5Z)-13-[(pentylcarbamoyl)amino]tridec-5-enoic acid
-
-
(5Z)-13-[(pentylcarbamoyl)amino]tridec-5-enoic acid
-
(8E)-13-[(pentylcarbamoyl)amino]tridec-8-enoic acid
-
-
(8E)-13-[(pentylcarbamoyl)amino]tridec-8-enoic acid
-
(8Z)-12-[(hexylcarbamoyl)amino]dodec-8-enoic acid
-
-
(8Z)-12-[(hexylcarbamoyl)amino]dodec-8-enoic acid
-
(8Z)-12-[[(pentylcarbamoyl)amino]oxy]dodec-8-enoic acid
-
-
(8Z)-12-[[(pentylcarbamoyl)amino]oxy]dodec-8-enoic acid
-
(8Z)-13-(4-pentyl-1H-1,2,3-triazol-1-yl)tridec-8-enoic acid
-
-
(8Z)-13-(4-pentyl-1H-1,2,3-triazol-1-yl)tridec-8-enoic acid
-
(8Z)-13-(5-pentyl-4,5-dihydro-1,3-oxazol-2-yl)tridec-8-enoic acid
-
-
(8Z)-13-(5-pentyl-4,5-dihydro-1,3-oxazol-2-yl)tridec-8-enoic acid
-
(8Z)-13-(5-pentylfuran-2-yl)tridec-8-enoic acid
-
-
(8Z)-13-(5-pentylfuran-2-yl)tridec-8-enoic acid
-
(8Z)-13-(heptanoylamino)tridec-8-enoic acid
-
-
(8Z)-13-(heptanoylamino)tridec-8-enoic acid
-
(8Z)-13-[(pentylcarbamothioyl)amino]tridec-8-enoic acid
-
-
(8Z)-13-[(pentylcarbamothioyl)amino]tridec-8-enoic acid
-
(8Z)-13-[(pentylcarbamoyl)amino]tridec-8-enoic acid
-
-
(8Z)-13-[(pentylcarbamoyl)amino]tridec-8-enoic acid
-
(8Z)-13-[(pentylcarbamoyl)oxy]tridec-8-enoic acid
-
-
(8Z)-13-[(pentylcarbamoyl)oxy]tridec-8-enoic acid
-
(8Z)-13-[heptanoyl(methyl)amino]tridec-8-enoic acid
-
-
(8Z)-13-[heptanoyl(methyl)amino]tridec-8-enoic acid
-
(8Z)-13-[heptanoyl(propan-2-yl)amino]tridec-8-enoic acid
-
-
(8Z)-13-[heptanoyl(propan-2-yl)amino]tridec-8-enoic acid
-
(8Z)-13-[methyl(pentylcarbamoyl)amino]tridec-8-enoic acid
-
-
(8Z)-13-[methyl(pentylcarbamoyl)amino]tridec-8-enoic acid
-
(8Z)-13-[methyl[methyl(pentyl)carbamoyl]amino]tridec-8-enoic acid
-
-
(8Z)-13-[methyl[methyl(pentyl)carbamoyl]amino]tridec-8-enoic acid
-
(8Z)-13-[[(butylamino)(oxo)acetyl]amino]tridec-8-enoic acid
-
-
(8Z)-13-[[(butylamino)(oxo)acetyl]amino]tridec-8-enoic acid
-
(8Z)-13-[[(pentyloxy)carbonyl]amino]tridec-8-enoic acid
-
-
(8Z)-13-[[(pentyloxy)carbonyl]amino]tridec-8-enoic acid
-
(8Z)-13-[[methyl(pentyl)carbamoyl]amino]tridec-8-enoic acid
-
-
(8Z)-13-[[methyl(pentyl)carbamoyl]amino]tridec-8-enoic acid
-
(8Z)-13-[[[butyl(methyl)amino](oxo)acetyl](methyl)amino]tridec-8-enoic acid
-
-
(8Z)-13-[[[butyl(methyl)amino](oxo)acetyl](methyl)amino]tridec-8-enoic acid
-
(8Z)-14-(hexylamino)-14-oxotetradec-8-enoic acid
-
-
(8Z)-14-(hexylamino)-14-oxotetradec-8-enoic acid
-
(8Z)-14-[(butylcarbamoyl)amino]tetradec-8-enoic acid
-
-
(8Z)-14-[(butylcarbamoyl)amino]tetradec-8-enoic acid
-
(8Z)-14-[hexyl(methyl)amino]-14-oxotetradec-8-enoic acid
-
-
(8Z)-14-[hexyl(methyl)amino]-14-oxotetradec-8-enoic acid
-
(8Z,11Z)-16-[(ethylcarbamoyl)amino]hexadeca-8,11-dienoic acid
-
-
(8Z,11Z)-16-[(ethylcarbamoyl)amino]hexadeca-8,11-dienoic acid
-
(E)-phenyl(3-phenyloxiran-2-yl)methanone oxime
-
IC50 is 0.00029 mM
(E)-phenyl(3-phenyloxiran-2-yl)methanone oxime
-
IC50 is 0.0035 mM
(E)-[3-(2-naphthyl)oxiran-2-yl](phenyl)methanone oxime
-
IC50 is 0.035 mM
(E)-[3-(2-naphthyl)oxiran-2-yl](phenyl)methanone oxime
-
IC50 is 0.042 mM
(R)-4-cyano-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-benzamide
-
(R)-4-cyano-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-benzamide
-
(R)-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-hydroxy-nicotinamide
-
(R)-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-hydroxy-nicotinamide
-
(S)-4-cyano-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-benzamide
-
(S)-4-cyano-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-benzamide
-
(S)-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-hydroxy-nicotinamide
-
(S)-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-hydroxy-nicotinamide
-
1,1,1-Trichloropropene 2,3-oxide
-
-
1,1,1-Trichloropropene 2,3-oxide
-
-
1,1,1-Trichloropropene 2,3-oxide
-
-
1,1,1-Trichloropropene 2,3-oxide
-
-
1,1,1-Trichloropropene 2,3-oxide
-
-
1,3-dicyclohexyl urea
-
0.1 mM, complete inhibition of epoxide hydrolase activity, no inhibition of phosphatase activity; complete inhibition at 0.1 mM
1,3-dicyclohexyl urea
-
-
1,3-disubstituted amides
-
potent and stable inhibition, Ki in the nanomolar range, mechanism
1,3-disubstituted amides
-
potent and stable inhibition, Ki in the nanomolar range, mechanism
1,3-disubstituted amides
-
potent and stable inhibition, Ki in the nanomolar range, mechanism
1,3-disubstituted carbamate derivatives
-
potent and stable inhibition, Ki in the nanomolar range, mechanism
1,3-disubstituted carbamate derivatives
-
potent and stable inhibition, Ki in the nanomolar range, mechanism
1,3-disubstituted carbamate derivatives
-
potent and stable inhibition, Ki in the nanomolar range, mechanism
1,3-disubstituted urea derivatives
-
potent and stable inhibition, Ki in the nanomolar range, mechanism
1,3-disubstituted urea derivatives
-
potent and stable inhibition, Ki in the nanomolar range, mechanism
1,3-disubstituted urea derivatives
-
potent and stable inhibition, Ki in the nanomolar range, mechanism
1-(1-acetylpiperidin-4-yl)-3-cycloheptylurea
-
-
1-(1-acetylpiperidin-4-yl)-3-cycloheptylurea
-
1-(1-acetylpiperidin-4-yl)-3-cycloheptylurea
-
1-(1-acetylpiperidin-4-yl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
-
1-(1-acetylpiperidin-4-yl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
1-(1-acetylpiperidin-4-yl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
1-(1-acetylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea
-
-
1-(1-acetylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea
-
1-(1-acetylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea
-
1-(1-acetylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea
-
1-(1-acetylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea
-
-
1-(1-acetypiperidin-4-yl)-3-adamantanylurea
-
1-(1-acetypiperidin-4-yl)-3-adamantanylurea
APAU, a tight binding inhibitor of enzyme sEH
1-(1-acetypiperidin-4-yl)-3-adamantanylurea
APAU, a tight binding inhibitor of enzyme sEH
1-(1-acetypiperidin-4-yl)-3-adamantanylurea
-
-
1-(1-acetypiperidin-4-yl)-3-adamantanylurea
APAU, a tight binding inhibitor of enzyme sEH
1-(1-butanoylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea
-
1-(1-butanoylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea
-
-
1-(1-methanesulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)-urea
-
1-(1-methanesulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)-urea
-
i.e. TUPS
1-(1-methanesulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)-urea
-
0.001 mM markedly inhibits the basal and angiotensin II-induced sEH activity
1-(1-methanesulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)-urea
i.e. TUPS
1-(1-methanesulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)-urea
-
0.001 mM markedly inhibits the basal and angiotensin II-induced sEH activity
1-(1-methylsulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)-urea
-
potent inhibitor of sEH
1-(1-methylsulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)-urea
-
potent inhibitor of sEH
1-(1-methylsulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxyphenyl)-urea
-
1-(1-methylsulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxyphenyl)-urea
-
-
1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy) phenyl) urea
i.e. AR9276, reduces atherosclerotic lesions in the aorta and carotid artery and attenuates abdominal aortic aneurysm formation in apolipoprotein E-deficient mice
1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy) phenyl) urea
i.e. AR9276
1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)-urea
-
1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)-urea
-
i.e. AR9276
1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)-urea
i.e. AR9276
1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea
-
1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethyl)phenyl]urea
-
-
1-(3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)-3-phenylpropan-1-one
-
1-(3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)-3-phenylpropan-1-one
-
1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea
-
-
1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea
-
1-(4-tert-butylphenyl)-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea
-
1-(4-tert-butylphenyl)-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea
-
-
1-(4-trifluoro-methoxy-phenyl)-3-(1-propionylpiperidin-4-yl)urea
TPPU, a tight binding inhibitor of enzyme sEH
1-(4-trifluoro-methoxy-phenyl)-3-(1-propionylpiperidin-4-yl)urea
TPPU, a tight binding inhibitor of enzyme sEH
1-(4-trifluoro-methoxy-phenyl)-3-(1-propionylpiperidin-4-yl)urea
TPPU, a tight binding inhibitor of enzyme sEH
1-(adamantan-1-yl)-3-(1-propionylpiperidin-4-yl)urea
-
1-(adamantan-1-yl)-3-(1-propionylpiperidin-4-yl)urea
-
1-(adamantan-1-yl)-3-(1-propionylpiperidin-4-yl)urea
-
1-(cis-4-ethylcyclohexyl)-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea
-
1-(cis-4-ethylcyclohexyl)-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea
-
-
1-adamantan-1-yl-3-(5-(2-(2-ethoxyethoxy)ethoxy)pentyl)urea
-
-
1-adamantan-1-yl-3-(5-(2-(2-ethoxyethoxy)ethoxy)pentyl)urea
-
-
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
-
i.e. 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
-
i.e. 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
i.e. 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
-
i.e. 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
-
i.e. 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
-
i.e. 1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
1-adamantan-3-(5-(2-(2-ethylethoxy) ethoxy)pentyl) urea
-
1-adamantan-3-(5-(2-(2-ethylethoxy) ethoxy)pentyl) urea
-
1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea
-
highly potent and selective sEH inhibitor
1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea
-
highly potent and selective sEH inhibitor
1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea
-
1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea
-
-
1-adamantanyl-3-(5-(2-(2-ethoxyethoxy)ethoxy)pentyl)urea
-
1-adamantanyl-3-(5-(2-(2-ethoxyethoxy)ethoxy)pentyl)urea
-
i.e. AEPU
1-adamantanyl-3-(5-(2-(2-ethoxyethoxy)ethoxy)pentyl)urea
i.e. AEPU
1-adamantyl-3-cyclohexylurea
-
1-adamantyl-3-cyclohexylurea
-
-
1-adamantyl-3-cyclohexylurea
-
1-adamantyl-3-cyclohexylurea
a sEH-selective inhibitor
1-cycloheptyl-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea
-
1-cycloheptyl-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea
-
-
1-cyclohexyl-3-dodecyl urea
-
0.1 mM, complete inhibition of epoxide hydrolase activity, no inhibition of phosphatase activity; complete inhibition at 0.1 mM
1-cyclohexyl-3-dodecyl urea
-
-
1-cyclohexyl-3-dodecyl urea
-
1-cyclohexyl-3-dodecyl urea
-
i.e. CDU
1-cyclohexyl-3-dodecyl urea
i.e. CDU
1-cyclohexyl-3-dodecylurea
i.e. 1-cyclohexyl-3-dodecyl-urea, strong inhibition
1-cyclohexyl-3-dodecylurea
-
i.e. 1-cyclohexyl-3-dodecyl-urea
1-cyclohexyl-3-dodecylurea
-
i.e. 1-cyclohexyl-3-dodecyl-urea
1-cyclohexyl-3-dodecylurea
i.e. CDU
1-cyclohexyl-3-ethyl urea
-
0.1 mM, 54% inhibition of epoxide hydrolase activity, no inhibition of phosphatase activity; 54% inhibition at 0.1 mM
1-cyclohexyl-3-ethyl urea
-
-
1-cyclohexyl-3-ethyl urea
i.e. CEU
1-cyclohexyl-3-ethylurea
i.e. N-cyclohexyl-N'-ethylurea
1-cyclohexyl-3-ethylurea
-
i.e. N-cyclohexyl-N'-ethylurea
1-cyclohexyl-3-ethylurea
-
i.e. N-cyclohexyl-N'-ethylurea
1-cyclohexyl-3-hexyl urea
-
0.1 mM, complete inhibition of epoxide hydrolase activity, 4% inhibition of phosphatase activity; complete inhibition at 0.1 mM
1-cyclohexyl-3-hexyl urea
-
-
1-cyclohexyl-3-hexylurea
-
i.e. N-cyclohexyl-N'-hexylurea
1-cyclohexyl-3-hexylurea
-
i.e. N-cyclohexyl-N'-hexylurea
1-cyclohexyl-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea
-
1-cyclohexyl-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea
-
-
1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl) urea
-
i.e. TPAU
1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl) urea
i.e. TPAU
1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl)-urea
-
1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl)-urea
-
-
1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl)urea
-
-
1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl)urea
-
-
1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl)urea
-
-
1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea
-
1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea
-
1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)-urea
-
1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)-urea
-
-
1-[1-(2-methylbutanoyl)piperidin-4-yl]-3-[4-(propan-2-yl)phenyl]urea
-
1-[1-(2-methylbutanoyl)piperidin-4-yl]-3-[4-(propan-2-yl)phenyl]urea
-
-
1-[1-(2-methylbutanoyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
-
1-[1-(2-methylbutanoyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
-
-
1-[1-(2-methylbutanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
1-[1-(2-methylbutanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
-
1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
-
1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
-
-
1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
-
1-[1-(3-methylbutanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
1-[1-(3-methylbutanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
-
1-[1-(4,4,4-trifluorobutanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
1-[1-(4,4,4-trifluorobutanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
-
1-[1-(butylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
-
1-[1-(butylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
-
-
1-[1-(butylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
1-[1-(butylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
-
1-[1-(cyclopropylcarbonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
1-[1-(cyclopropylcarbonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
-
1-[1-(cyclopropylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
1-[1-(cyclopropylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
-
1-[1-(ethylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
1-[1-(ethylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
-
1-[1-(methylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
-
-
1-[1-(methylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
-
1-[1-(methylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
1-[1-(methylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
-
1-[1-(propan-2-ylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
1-[1-(propan-2-ylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
-
1-[1-(propylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
1-[1-(propylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
-
1-[1-[(2,2,2-trifluoroethyl)sulfonyl]piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
1-[1-[(2,2,2-trifluoroethyl)sulfonyl]piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
-
1-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
-
1-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
-
-
1-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
1-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
-
-
1-[3-(4-nitrophenyl)oxiran-2-yl]ethanol
-
IC50 is 0.0187 mM
1-[3-(4-nitrophenyl)oxiran-2-yl]ethanol
-
IC50 is 0.0023 mM
1-[3-(4-nitrophenyl)oxiran-2-yl]ethanone
-
IC50 is 0.269 mM
1-[3-(4-nitrophenyl)oxiran-2-yl]ethanone
-
IC50 is 0.163 mM
1-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea
-
1-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]-3-[1-(2-methylbutanoyl)piperidin-4-yl]urea
-
-
1-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]-3-[1-(3,3,3-trifluoropropanoyl)piperidin-4-yl]urea
-
1-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]-3-[1-(3,3,3-trifluoropropanoyl)piperidin-4-yl]urea
-
-
1-[4-(trifluoromethyl)phenyl]-3-[1-(3,3,3-trifluoropropanoyl)piperidin-4-yl]urea
-
1-[4-(trifluoromethyl)phenyl]-3-[1-(3,3,3-trifluoropropanoyl)piperidin-4-yl]urea
-
-
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
analysis of the crystal structure of enzyme-inhibitor complex
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
-
-
1-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
-
1-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
1-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
-
-
12-(3-adamantan-1-yl-ureido)-dodecanoic acid
-
-
12-(3-adamantan-1-yl-ureido)-dodecanoic acid
-
12-(3-adamantan-1-yl-ureido)-dodecanoic acid
-
i.e. AUDA
12-(3-adamantan-1-yl-ureido)-dodecanoic acid
AUDA
12-(3-adamantan-1-yl-ureido)-dodecanoic acid
-
-
12-(3-adamantan-1-yl-ureido)-dodecanoic acid
i.e. AUDA, binding structure, overview
12-(3-adamantan-1-yl-ureido)-dodecanoic acid
-
-
12-(3-adamantan-1-yl-ureido)-dodecanoic acid
AUDA
12-(3-adamantan-1-yl-ureido)-dodecanoic acid
-
-
12-(3-adamantan-1-yl-ureido)-dodecanoic acid
-
orally active inhibitor. Inhibition of soluble epoxide hydrolase is effective in persistently reducing blood pressure in female spontaneously hypertensive rats when 12-(3-adamantan-1-yl-ureido)-dodecanoic acid is applied during the perinatal phase
12-(3-adamantan-1-yl-ureido)-dodecanoic acid butyl ester
-
i.e. AUDA-BE
12-(3-adamantan-1-yl-ureido)-dodecanoic acid butyl ester
-
i.e. AUDA-BE, physiologic consequences of enzyme inhibition in vivo
12-(3-adamantan-1-yl-ureido)-dodecanoic acid butyl ester
-
selective sEH inhibitor
12-(3-adamantan-1-yl-ureido)-dodecanoic acid butyl ester
-
selective soluble epoxide hydrolase inhibitor
12-(3-adamantan-1-yl-ureido)-dodecanoic acid butyl ester
i.e. AUDA-BE
12-(3-adamantan-1-yl-ureido)-dodecanoic acid butyl ester
-
selective soluble epoxide hydrolase inhibitor
12-(3-adamantan-1-yl-ureido)-dodecanoic acid butylester
-
12-(3-adamantan-1-yl-ureido)-dodecanoic acid butylester
i.e. AUDA-BE
12-(3-adamantan-1-yl-ureido)dodecanoic acid
-
potent transition state inhibitor of sEH
12-(3-adamantan-1-yl-ureido)dodecanoic acid
AUDA
12-(3-adamantan-1-yl-ureido)dodecanoic acid
-
12-(3-adamantan-1-yl-ureido)dodecanoic acid
-
-
12-(3-adamantan-1-yl-ureido)dodecanoic acid
-
highly potent sEH inhibitor
12-(3-adamantan-1-yl-ureido)dodecanoic acid
-
selective soluble epoxide hydrolase inhibitor
12-(3-adamantan-1-yl-ureido)dodecanoic acid
-
potent transition state inhibitor of sEH
12-(3-adamantan-1-yl-ureido)dodecanoic acid
i.e. AUDA
12-(3-adamantan-1-yl-ureido)dodecanoic acid
AUDA
12-(3-adamantan-1-yl-ureido)dodecanoic acid
-
-
12-(3-adamantan-1-yl-ureido)dodecanoic acid
-
selective soluble epoxide hydrolase inhibitor
12-(3-adamantan-1-yl-ureido)dodecanoic acid
-
-
12-(3-adamantan-1-yl-ureido)dodecanoic acid
i.e. AUDA
12-(3-adamantan-1-yl-ureido)dodecanoic acid
AUDA
12-(3-adamantan-1-yl-ureido)dodecanoic acid butyl ester
AUDA-BE, displays improved bioavailability compared to AUDA
12-(3-adamantan-1-yl-ureido)dodecanoic acid butyl ester
-
highly potent sEH inhibitor
12-(3-adamantan-1-yl-ureido)dodecanoic acid butyl ester
AUDA-BE, displays improved bioavailability compared to AUDA, can be administered ip to improve stroke outcome in a mouse model of ischemia/reperfusion injury
12-(3-adamantan-1-yl-ureido)dodecanoic acid butyl ester
AUDA-BE
12-(3-adamantan-1-ylureido)-dodecanoic acid
-
very potent sEH inhibitor, sEH inhibitor treatment was not associated with an attenuation of lipopolysaccharide-induced inflammatory gene expression in the liver, and 12-(3-adamantan-1-ylureido)-dodecanoic acid does not protect from lipopolysaccharide-induced neutrophil infiltration
12-(3-adamantan-1-ylureido)-dodecanoic acid
-
-
12-(3-adamantan-1-ylureido)dodecanoic acid
-
-
12-(3-adamantan-1-ylureido)dodecanoic acid
-
-
12-(3-adamantan-1-ylureido)dodecanoic acid
-
-
12-(3-adamantan-1-ylureido)dodecanoic acid butyl ester
-
-
12-(3-adamantan-1-ylureido)dodecanoic acid butyl ester
-
-
12-(3-adamantan-1-ylureido)dodecanoic acid butyl ester
-
-
12-(3-adamantane-1-yl-ureido)-dodecanoic acid
-
-
12-(3-adamantane-1-yl-ureido)-dodecanoic acid
-
12-(3-adamantyl-ureido)-dodecanoic acid
AUDA, a tight binding inhibitor of enzyme sEH
12-(3-adamantyl-ureido)-dodecanoic acid
AUDA, a tight binding inhibitor of enzyme sEH
12-(3-adamantyl-ureido)-dodecanoic acid
AUDA, a tight binding inhibitor of enzyme sEH
12-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]dodecanoic acid
-
-
12-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]dodecanoic acid
-
12-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]dodecanoic acid
-
-
12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid
-
-
12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid
i.e. AUDA
12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid
AUDA
12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid
-
AUDA
13-(heptanoylamino)tridec-5-ynoic acid
-
-
13-(heptanoylamino)tridec-5-ynoic acid
-
13-[(pentylcarbamoyl)amino]tridec-8-ynoic acid
-
-
13-[(pentylcarbamoyl)amino]tridec-8-ynoic acid
-
13-[methyl[methyl(pentyl)carbamoyl]amino]tridec-5-ynoic acid
-
-
13-[methyl[methyl(pentyl)carbamoyl]amino]tridec-5-ynoic acid
-
2,2'-Dithiopyridine
-
73% inhibition at 1 mM at pH 7.4
2,2'-Dithiopyridine
-
66% inhibition at 1 mM at pH 7.4
2,3-epoxy-1,3-diphenyl-propan-1-one
-
IC50: 0.023 mM
2,3-epoxy-1,3-diphenyl-propan-1-one
-
IC50: 0.0029 mM
2,3-epoxy-1,3-diphenyl-propan-1-one
-
IC50: 0.0034 mM
2,3-epoxy-1-(4-bromophenyl)-3-phenyl-propan-1-one
-
IC50: 0.013 mM
2,3-epoxy-1-(4-bromophenyl)-3-phenyl-propan-1-one
-
IC50: 0.0006 mM
2,3-epoxy-1-(4-bromophenyl)-3-phenyl-propan-1-one
-
IC50: 0.00089 mM
2,3-epoxy-1-(4-ethylphenyl)-3-phenyl-propan-1-one
-
IC50: 0.03 mM
2,3-epoxy-1-(4-ethylphenyl)-3-phenyl-propan-1-one
-
IC50: 0.0017 mM
2,3-epoxy-1-(4-ethylphenyl)-3-phenyl-propan-1-one
-
IC50: 0.0014 mM
2,3-epoxy-1-(4-fluorophenyl)-3-phenyl-propan-1-one
-
IC50: 0.022 mM
2,3-epoxy-1-(4-fluorophenyl)-3-phenyl-propan-1-one
-
IC50: 0.0018 mM
2,3-epoxy-1-(4-fluorophenyl)-3-phenyl-propan-1-one
-
IC50: 0.0012 mM
2,3-epoxy-1-(4-methoxyphenyl)-3-phenyl-propan-1-one
-
IC50: 0.0054 mM
2,3-epoxy-1-(4-methoxyphenyl)-3-phenyl-propan-1-one
-
IC50: 0.00032 mM
2,3-epoxy-1-(4-methoxyphenyl)-3-phenyl-propan-1-one
-
IC50: 0.00021 mM
2,3-epoxy-1-(4-nitroxyphenyl)-3-phenyl-propan-1-one
-
IC50: 0.016 mM
2,3-epoxy-1-(4-nitroxyphenyl)-3-phenyl-propan-1-one
-
IC50: 0.0015 mM
2,3-epoxy-1-(4-nitroxyphenyl)-3-phenyl-propan-1-one
-
IC50: 0.019 mM
2,3-epoxy-1-(4-phenylphenyl)-3-phenyl-propan-1-one
-
IC50: 0.00137 mM
2,3-epoxy-1-(4-phenylphenyl)-3-phenyl-propan-1-one
-
IC50: 0.0025 mM
2,3-epoxy-3-(4-bromophenyl)-1-phenyl-propan-1-one
-
IC50: 0.0022 mM
2,3-epoxy-3-(4-bromophenyl)-1-phenyl-propan-1-one
-
IC50: 0.0007 mM
2,3-epoxy-3-(4-bromophenyl)-1-phenyl-propan-1-one
-
IC50: 0.00012 mM
2,3-epoxy-3-(4-ethylphenyl)-1-phenyl-propan-1-one
-
IC50: 0.0056 mM
2,3-epoxy-3-(4-ethylphenyl)-1-phenyl-propan-1-one
-
IC50: 0.0019 mM
2,3-epoxy-3-(4-ethylphenyl)-1-phenyl-propan-1-one
-
IC50: 0.00016 mM
2,3-epoxy-3-(4-fluorophenyl)-1-phenyl-propan-1-one
-
IC50: 0.0047 mM
2,3-epoxy-3-(4-fluorophenyl)-1-phenyl-propan-1-one
-
IC50: 0.0013 mM
2,3-epoxy-3-(4-fluorophenyl)-1-phenyl-propan-1-one
-
IC50: 0.00048 mM
2,3-epoxy-3-(4-methoxyphenyl)-1-phenyl-propan-1-one
-
IC50: 0.0028 mM
2,3-epoxy-3-(4-methoxyphenyl)-1-phenyl-propan-1-one
-
IC50: 0.0002 mM
2,3-epoxy-3-(4-methoxyphenyl)-1-phenyl-propan-1-one
-
IC50: 0.00019 mM
2,3-epoxy-3-(4-n-butylphenyl)-1-phenyl-propan-1-one
-
IC50: 0.0017 mM
2,3-epoxy-3-(4-n-butylphenyl)-1-phenyl-propan-1-one
-
IC50: 0.00015 mM
2,3-epoxy-3-(4-nitrophenyl)-1-phenyl-propan-1-one
-
IC50: 0.011 mM
2,3-epoxy-3-(4-nitrophenyl)-1-phenyl-propan-1-one
-
IC50: 0.00018 mM
2,3-epoxy-3-(4-nitrophenyl)-1-phenyl-propan-1-one
-
IC50: 0.00038 mM
2-(2,4-dichlorophenyl)-1-[6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl]ethanone
-
2-(2,4-dichlorophenyl)-1-[6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl]ethanone
-
2-(2-naphthyl)-3-(phenylsulfinyl)oxirane
-
IC50 is 0.070 mM
2-(2-naphthyl)-3-(phenylsulfinyl)oxirane
-
IC50 is 0.073 mM
2-(tricyclo[3.3.1.13,7]dec-1-yl)-N-[1-(trifluoroacetyl)piperidin-4-yl]acetamide
-
-
2-(tricyclo[3.3.1.13,7]dec-1-yl)-N-[1-(trifluoroacetyl)piperidin-4-yl]acetamide
-
2-([[2-(adamantan-1-yl)ethyl]amino]methyl)phenol
-
2-([[2-(adamantan-1-yl)ethyl]amino]methyl)phenol
-
-
2-Bromo-4'-nitroacetophenone
-
-
2-Bromo-4'-nitroacetophenone
-
complete inhibition at 1 mM at pH 7.4
2-Bromo-4'-nitroacetophenone
-
-
2-Bromo-4'-nitroacetophenone
-
-
2-Bromo-4'-nitroacetophenone
-
81% inhibition at 1 mM at pH 7.4
2-Bromo-4'-nitroacetophenone
-
-
2-Bromo-4'-nitroacetophenone
-
-
2-cyclohexa-1,5-dien-1-yl-3-(phenylsulfinyl)oxirane
-
IC50 is 0.00031 mM
2-cyclohexa-1,5-dien-1-yl-3-(phenylsulfinyl)oxirane
-
IC50 is 0.0023 mM
2-cyclohexa-1,5-dien-1-yl-3-[methoxy(phenyl)methyl]oxirane
-
IC50 is 0.034 mM
2-cyclohexa-1,5-dien-1-yl-3-[methoxy(phenyl)methyl]oxirane
-
IC50 is 0.103 mM
2-naphthyl(3-phenyloxiran-2-yl)methanone
-
IC50 is 0.00028 mM
2-naphthyl(3-phenyloxiran-2-yl)methanone
-
IC50 is 0.0014 mM
2-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-N-[4-(trifluoromethoxy)phenyl]acetamide
-
2-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-N-[4-(trifluoromethoxy)phenyl]acetamide
-
-
2-[2-(adamantan-1-yl)ethyl]-N-(3,5-dimethyladamantan-1-yl)hydrazine-1-carboxamide
-
2-[2-(adamantan-1-yl)ethyl]-N-(3,5-dimethyladamantan-1-yl)hydrazine-1-carboxamide
-
2-[2-(adamantan-1-yl)ethyl]-N-(3,5-dimethyladamantan-1-yl)hydrazine-1-carboxamide
-
2-[2-(adamantan-1-yl)ethyl]-N-[(adamantan-1-yl)methyl]hydrazine-1-carboxamide
-
2-[2-(adamantan-1-yl)ethyl]-N-[(adamantan-1-yl)methyl]hydrazine-1-carboxamide
-
2-[2-(adamantan-1-yl)ethyl]-N-[(adamantan-1-yl)methyl]hydrazine-1-carboxamide
-
2-[3-(adamantan-1-yl)propyl]-N-(3,5-dimethyladamantan-1-yl)hydrazine-1-carboxamide
-
2-[3-(adamantan-1-yl)propyl]-N-(3,5-dimethyladamantan-1-yl)hydrazine-1-carboxamide
-
2-[3-(adamantan-1-yl)propyl]-N-(3,5-dimethyladamantan-1-yl)hydrazine-1-carboxamide
-
2-[methoxy(phenyl)methyl]-3-(2-naphthyl)oxirane
-
IC50 is 0.00134 mM
2-[methoxy(phenyl)methyl]-3-(2-naphthyl)oxirane
-
IC50 is 0.00048 mM
3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl[4-(trifluoromethyl)phenyl]methanone
-
3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl[4-(trifluoromethyl)phenyl]methanone
-
3-(3-amino-3-oxopropyl)-N-(4-chlorophenyl)-3-phenylpiperidine-1-carboxamide
-
3-(3-amino-3-oxopropyl)-N-(4-chlorophenyl)-3-phenylpiperidine-1-carboxamide
-
3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propylamine
-
3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propylamine
-
3-([cis-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]cyclohexyl]oxy)benzoic acid
-
-
3-([cis-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]cyclohexyl]oxy)benzoic acid
-
3-([[(adamantan-1-yl)methyl]carbamoyl]amino)adamantan-1-yl trifluoroacetate
-
3-([[(adamantan-1-yl)methyl]carbamoyl]amino)adamantan-1-yl trifluoroacetate
-
3-([[(adamantan-1-yl)methyl]carbamoyl]amino)adamantan-1-yl trifluoroacetate
-
3-methyl-3-phenyl-N-(4-(pyridin-3-yl)benzyl)piperidine-1-carboxamide
-
3-methyl-3-phenyl-N-(4-(pyridin-3-yl)benzyl)piperidine-1-carboxamide
-
3-methyl-3-phenyl-N-(pyridin-4-yl)piperidine-1-carboxamide
-
3-methyl-3-phenyl-N-(pyridin-4-yl)piperidine-1-carboxamide
-
3-methyl-3-phenyl-N-[3-(pyridin-3-yl)propyl]piperidine-1-carboxamide
-
3-methyl-3-phenyl-N-[3-(pyridin-3-yl)propyl]piperidine-1-carboxamide
-
3-methyl-3-phenyl-N-[3-[(1S,2S)-2-phenylcyclopropyl]benzyl]piperidine-1-carboxamide
-
3-methyl-3-phenyl-N-[3-[(1S,2S)-2-phenylcyclopropyl]benzyl]piperidine-1-carboxamide
-
3-methyl-3-phenyl-N-[3-[2-(quinoxalin-6-yl)ethyl]benzyl]piperidine-1-carboxamide
-
3-methyl-3-phenyl-N-[3-[2-(quinoxalin-6-yl)ethyl]benzyl]piperidine-1-carboxamide
-
3-methyl-3-phenyl-N-[[2'-(trifluoromethyl)biphenyl-4-yl]methyl]piperidine-1-carboxamide
-
3-methyl-3-phenyl-N-[[2'-(trifluoromethyl)biphenyl-4-yl]methyl]piperidine-1-carboxamide
-
3-morpholinosydnonimine
i.e. SIN-1, a peroxonitrite generator, causes nitration on several tyrosine residues including Tyr383 and Tyr466. 1-adamantyl-3-cyclohexylurea in vitro decreases sensitivity to SIN-1
3-morpholinosydnonimine
i.e. SIN-1, a peroxonitrite generator, causes nitration on several tyrosine residues including Tyr383 and Tyr466. 1-adamantyl-3-cyclohexylurea in vitro decreases sensitivity to SIN-1
3-[1-[(4-chlorophenyl)carbamoyl]-3-(pyridin-2-yl)piperidin-3-yl]propanoic acid
-
3-[1-[(4-chlorophenyl)carbamoyl]-3-(pyridin-2-yl)piperidin-3-yl]propanoic acid
-
3-[1-[(4-chlorophenyl)carbamoyl]-3-(pyridin-3-yl)piperidin-3-yl]propanoic acid
-
3-[1-[(4-chlorophenyl)carbamoyl]-3-(pyridin-3-yl)piperidin-3-yl]propanoic acid
-
3-[1-[(4-chlorophenyl)carbamoyl]-3-(pyridin-4-yl)piperidin-3-yl]propanoic acid
-
3-[1-[(4-chlorophenyl)carbamoyl]-3-(pyridin-4-yl)piperidin-3-yl]propanoic acid
-
3-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]propanoic acid
-
3-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]propanoic acid
-
3-[1-[(4-chlorophenyl)carbamoyl]-3-[3-(trifluoromethyl)phenyl]piperidin-3-yl]propanoic acid
-
3-[1-[(4-chlorophenyl)carbamoyl]-3-[3-(trifluoromethyl)phenyl]piperidin-3-yl]propanoic acid
-
3-[1-[(4-chlorophenyl)carbamoyl]-3-[4-(trifluoromethyl)phenyl]piperidin-3-yl]propanoic acid
-
3-[1-[(4-chlorophenyl)carbamoyl]-3-[4-(trifluoromethyl)phenyl]piperidin-3-yl]propanoic acid
-
3-[3-(biphenyl-4-yl)-1-[(4-chlorophenyl)carbamoyl]piperidin-3-yl]propanoic acid
-
3-[3-(biphenyl-4-yl)-1-[(4-chlorophenyl)carbamoyl]piperidin-3-yl]propanoic acid
-
3-[4-[(1-[[(1R,3S)-2,2-dimethyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
-
3-[4-[(1-[[(1R,3S)-2,2-dimethyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
-
3-[4-[(1-[[(1S,2R)-2-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
-
3-[4-[(1-[[(1S,2R)-2-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
-
3-[4-[(1-[[(1S,2R,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
-
3-[4-[(1-[[(1S,2R,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
-
3-[4-[(1-[[(1s,2R,3S)-2,3-bis(4-fluorophenyl)cyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
-
3-[4-[(1-[[(1s,2R,3S)-2,3-bis(4-fluorophenyl)cyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
-
3-[4-[(1-[[(1s,2R,3S)-2,3-diphenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
-
3-[4-[(1-[[(1s,2R,3S)-2,3-diphenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
-
3-[4-[(1-[[(1S,2S,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
-
3-[4-[(1-[[(1S,2S,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
-
4'-hydroxy-N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide
-
4'-hydroxy-N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide
-
4,4-diphenyl-N-(pyridin-3-yl)-butyramide
-
4,4-diphenyl-N-(pyridin-3-yl)-butyramide
-
4-((4-(3-(adamantan-1-yl)ureido)trans-cyclohexyl)oxy)benzoic acid
-
4-((4-(3-(adamantan-1-yl)ureido)trans-cyclohexyl)oxy)benzoic acid
-
4-((4-(3-(adamantan-1-yl)ureido)trans-cyclohexyl)oxy)benzoic acid
-
4-(3-benzoyloxiran-2-yl)benzoic acid
-
IC50 is above 0.5 mM
4-(3-benzoyloxiran-2-yl)benzoic acid
-
IC50 is above 0.5 mM
4-(3-cyanophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide
-
4-(3-cyanophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide
-
4-(5-phenyl-3-[3-[3-(4-trifluoromethyl-phenyl)-ureido]-propyl]-pyrazol-1-yl)-benzenesulfonamide
dual inhibitor of cyclooxygenase-2 and soluble epoxide hydrolase
4-(5-phenyl-3-[3-[3-(4-trifluoromethyl-phenyl)-ureido]-propyl]-pyrazol-1-yl)-benzenesulfonamide
-
dual inhibitor of cyclooxygenase-2 and soluble epoxide hydrolase. Inhibitor shows the best pharmacokinetic profiles in both mice and rats. Following subcutaneous administration at 10 mg/kg, compound exhibits antiallodynic activity that is more effective than the same dose of either COX-2 inhibitor celecoxib or sEH inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid alone, as well as coadministration of both inhibitors
4-([3-(2-naphthyl)oxiran-2-yl]carbonyl)benzoic acid
-
IC50 is 0.00016 mM
4-([3-(2-naphthyl)oxiran-2-yl]carbonyl)benzoic acid
-
IC50 is 0.00008 mM
4-([3-(4-fluorophenyl)oxiran-2-yl]carbonyl)benzoic acid
-
IC50 is 0.113 mM
4-([3-(4-fluorophenyl)oxiran-2-yl]carbonyl)benzoic acid
-
IC50 is 0.103 mM
4-([trans-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]cyclohexyl]oxy)benzoic acid
-
-
4-([trans-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]cyclohexyl]oxy)benzoic acid
-
4-bromo-4'-methoxychalcone
-
IC50: 0.0048 mM
4-bromo-4'-methoxychalcone
-
IC50: 0.00027 mM
4-bromo-4'-methoxychalcone
-
IC50: 0.00021 mM
4-cyano-N-[3,3-bis-(4-fluorophenyl)-propyl]-benzamide
-
4-cyano-N-[3,3-bis-(4-fluorophenyl)-propyl]-benzamide
-
4-fluorochalcone oxide
-
87% inhibition at 0.1 mM, competitive substrate
4-fluorochalcone oxide
-
-
4-fluorochalcone oxide
-
IC50 is 0.026 mM
4-fluorochalcone oxide
-
-
4-fluorochalcone oxide
-
inhibition of the epoxide hydrolase activity
4-fluorochalcone oxide
-
complete inhibition of recombinant and native enzyme at 0.057 mM
4-nitrobenzenesulfonyl fluoride
-
94% inhibition at 1 mM at pH 7.4
4-nitrobenzenesulfonyl fluoride
-
47% inhibition at 1 mM at pH 7.4
4-oxo-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
4-oxo-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
4-oxo-N-(2-phenylcyclopropyl)-6-(pyridin-4-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
4-oxo-N-(2-phenylcyclopropyl)-6-(pyridin-4-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
4-oxo-N-(3-phenylcyclopentyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
4-oxo-N-(3-phenylcyclopentyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
4-oxo-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
4-oxo-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
4-oxo-N-[(1S,2R)-2-phenylcyclopropyl]-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
4-oxo-N-[(1S,2R)-2-phenylcyclopropyl]-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
4-Phenylchalcone oxide
-
complete inhibition at 0.1 mM, competitive substrate
4-Phenylchalcone oxide
-
-
4-Phenylchalcone oxide
-
-
4-[(3-phenyloxiran-2-yl)carbonyl]benzoic acid
-
IC50 is 0.144 mM
4-[(3-phenyloxiran-2-yl)carbonyl]benzoic acid
-
IC50 is 0.073 mM
4-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]butanoic acid
-
4-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]butanoic acid
-
4-[3-(4-fluorobenzoyl)oxiran-2-yl]benzoic acid
-
IC50 is above 0.5 mM
4-[3-(4-fluorobenzoyl)oxiran-2-yl]benzoic acid
-
IC50 is above 0.5 mM
4-[[(1r,4r)-4-([[(adamantan-1-yl)methyl]carbamoyl]amino)cyclohexyl]oxy]benzoic acid
-
4-[[(1r,4r)-4-([[(adamantan-1-yl)methyl]carbamoyl]amino)cyclohexyl]oxy]benzoic acid
-
4-[[(1r,4r)-4-([[(adamantan-1-yl)methyl]carbamoyl]amino)cyclohexyl]oxy]benzoic acid
-
4-[[(1r,4r)-4-[[(3,5,7-trimethyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
-
4-[[(1r,4r)-4-[[(3,5,7-trimethyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
-
4-[[(1r,4r)-4-[[(3,5,7-trimethyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
-
4-[[(1r,4r)-4-[[(3,5-dimethyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
-
4-[[(1r,4r)-4-[[(3,5-dimethyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
-
4-[[(1r,4r)-4-[[(3,5-dimethyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
-
4-[[(1r,4r)-4-[[(3-chloroadamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
-
4-[[(1r,4r)-4-[[(3-chloroadamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
-
4-[[(1r,4r)-4-[[(3-chloroadamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
-
4-[[(1r,4r)-4-[[(3-ethyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
-
4-[[(1r,4r)-4-[[(3-ethyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
-
4-[[(1r,4r)-4-[[(3-ethyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
-
4-[[(1r,4r)-4-[[(3-methyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
-
4-[[(1r,4r)-4-[[(3-methyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
-
4-[[(1r,4r)-4-[[(3-methyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
-
4-[[(2R,5R)-5-[[(2-oxoadamantan-1-yl)carbamoyl]amino]piperidin-2-yl]oxy]benzoic acid
-
4-[[(2R,5R)-5-[[(2-oxoadamantan-1-yl)carbamoyl]amino]piperidin-2-yl]oxy]benzoic acid
-
4-[[(2R,5R)-5-[[(2-oxoadamantan-1-yl)carbamoyl]amino]piperidin-2-yl]oxy]benzoic acid
-
4-[[cis-4-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)cyclohexyl]oxy]benzoic acid
-
-
4-[[cis-4-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)cyclohexyl]oxy]benzoic acid
-
5-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]pentanoic acid
-
5-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]pentanoic acid
-
5-[[(adamantan-1-yl)carbamoyl]amino]pentanoic acid
-
5-[[(adamantan-1-yl)carbamoyl]amino]pentanoic acid
-
5-[[(adamantan-1-yl)carbamoyl]amino]pentanoic acid
-
6'-(methylsulfonyl)-N-(2-phenylcyclopropyl)-1H,4'H-spiro[azepane-4,3'-chromene]-1-carboxamide
-
6'-(methylsulfonyl)-N-(2-phenylcyclopropyl)-1H,4'H-spiro[azepane-4,3'-chromene]-1-carboxamide
-
6-(1-methyl-1H-pyrazol-5-yl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
6-(1-methyl-1H-pyrazol-5-yl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
6-(methylsulfonyl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
6-(methylsulfonyl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
6-amino-N-(2,4-dichlorobenzyl)pyridine-3-carboxamide
-
6-amino-N-(2,4-dichlorobenzyl)pyridine-3-carboxamide
-
6-amino-N-(3,3-diphenylpropyl)pyridine-3-carboxamide
-
6-amino-N-(3,3-diphenylpropyl)pyridine-3-carboxamide
-
6-fluoro-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
6-fluoro-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
6-[(1-methyl-1H-pyrazol-5-yl)amino]-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
6-[(1-methyl-1H-pyrazol-5-yl)amino]-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
7-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
-
7-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
-
-
9-[(pentylcarbamoyl)amino]non-4-ynoic acid
-
-
9-[(pentylcarbamoyl)amino]non-4-ynoic acid
-
acetone
-
-
acetone
-
hydration of trans-stilbene oxide
acetonitrile
-
89% loss of activity at 5% acetonitrile
acetonitrile
-
hydration of trans-stilbene oxide
Al3+
-
20% inhibition at 1 mM
Al3+
-
10% inhibition at 1 mM
Al3+
-
5 mM, more than 90% inhibition
Al3+
-
20% inhibition at 1 mM
APAU
-
i.e. N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
APAU
-
i.e. N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
APAU
i.e. N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
APAU
-
i.e. N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
APAU
-
i.e. N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
APAU
-
i.e. N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
AUDA
-
i.e. 12-(3-adamantan-1-ylureido)dodecanoic acid
AUDA
-
i.e. 12-(3-adamantan-1-ylureido)dodecanoic acid
AUDA
i.e. 12-(3-adamantan-1-yl-ureido) dodecanoic acid, strong inhibition
AUDA
-
i.e. 12-(3-adamantan-1-yl-ureido)-dodecanoic acid
AUDA
-
i.e. 12-(3-adamantan-1-yl-ureido) dodecanoic acid
AUDA
i.e. 12-(3-adamantan-1-ylureido)dodecanoic acid
AUDA
-
i.e. 12-(3-adamantan-1-ylureido)dodecanoic acid
AUDA
-
i.e. 12-(3-adamantan-1-yl-ureido) dodecanoic acid
AUDA
-
i.e. 12-(3-adamantan-1-ylureido)dodecanoic acid
AUDA
-
i.e. 12-(3-adamantan-1-yl-ureido) dodecanoic acid, inhibition in vivo by intracerebroventricular delivery
AUDA
-
i.e. 12-(3-adamantan-1-ylureido)dodecanoic acid
Ba2+
-
20% inhibition at 1 mM
Ba2+
-
40% inhibition at 1 mM
Ba2+
-
30% inhibition at 1 mM
beta-naphthoflavone
-
1 mM, 50% inhibition
Ca2+
-
inhibition of Mg2+-dependent acrtivity
Ca2+
-
25% inhibition at 1 mM
Ca2+
-
20% inhibition at 1 mM
Ca2+
-
30% inhibition at 1 mM
carbodiimide/glycine methyl ester
-
48% inhibition at 1 mM at pH 5.2, no inhibition at pH 7.4
carbodiimide/glycine methyl ester
-
65% inhibition at 1 mM at pH 5.2, 17% at pH 7.4
Cd2+
-
inhibition of phosphatase activity and epoxide hydrolase activity
Cd2+
-
complete inhibition at 1 mM
Cd2+
-
complete inhibition at 1 mM
Cd2+
-
nearly complete inhibition at 1 mM
Cd2+
-
60% inhibition at 1 mM
chalcone
-
microsomal activity with cis-stilbene oxide as substrate, cytosolic enzyme form cEHCSO and cEHTSO
Chalcone oxide
-
1 mM, 98% inhibition
Chalcone oxide
-
inhibits hydration of (11S,12S)-epoxy-5,14-cis-7,9-trans-eicosatetraenoic acid
Chalcone oxide
-
0.1 mM, 80% inhibition of epoxide hydrolase activity, no inhibition of phosphatase activity; 80% inhibition at 0.1 mM, competitive substrate
Chalcone oxide
-
IC50 is 0.055 mM
cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
-
-
cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
-
-
cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
-
-
cis-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]-benzoic acid
-
cis-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]-benzoic acid
-
Clofibrate
-
slight inhibition of enzyme from untreated mice, slight activation of the enzyme from clofibrate-treated mice
Clofibrate
-
2 mM, 70-100% inhibition
Co2+
-
inhibition of Mg2+-dependent acrtivity
Co2+
-
30% inhibition at 1 mM
Co2+
-
45% inhibition at 1 mM
Co2+
-
15% inhibition at 1 mM
Co2+
-
30% inhibition at 1 mM
Cu2+
-
inhibition of phosphatase activity and epoxide hydrolase activity
Cu2+
-
nearly complete inhibition at 1 mM
Cu2+
-
complete inhibition at 1 mM
Cu2+
-
5 mM, more than 90% inhibition
Cu2+
-
over 95% inhibition at 1 mM
Cu2+
-
30% inhibition at 1 mM
cyclohexane 1,2-oxide
-
-
cyclohexane 1,2-oxide
-
-
cyclohexane 1,2-oxide
-
-
cyclohexane 1,2-oxide
-
-
cyclohexane 1,2-oxide
-
-
Cyclohexene oxide
-
-
Cyclohexene oxide
-
weak inhibitor
dicyclohexylurea
-
dicyclohexylurea
-
inhibition of the epoxide hydrolase activity
diethyldicarbonate
-
72% inhibition at 1 mM at pH 7.4
diethyldicarbonate
-
80% inhibition at 1 mM at pH 7.4
Dimethylsulfoxide
-
-
DTNB
-
86% inhibition at 1 mM at pH 7.4
DTNB
-
59% inhibition at 1 mM at pH 7.4
ethanol
-
3% inhibition at 3% ethanol
ethanol
-
hydration of trans-stilbene oxide
Fe2+
-
inhibition of Mg2+-dependent acrtivity
Fe2+
-
20% inhibition at 1 mM
Fe2+
-
5 mM, more than 90% inhibition
Fe2+
-
10% inhibition at 1 mM
Fe3+
-
inhibition of Mg2+-dependent acrtivity
Fe3+
-
15% inhibition at 1 mM
Fe3+
-
5 mM, more than 90% inhibition
Fe3+
-
20% inhibition at 1 mM
Hg2+
-
inhibition of phosphatase activity and epoxide hydrolase activity
Hg2+
-
complete inhibition at 1 mM
Hg2+
-
complete inhibition at 1 mM
Hg2+
-
complete inhibition at 1 mM
Hg2+
-
70% inhibition at 1 mM
m-chloroperbenzoic acid
-
-
m-chloroperbenzoic acid
-
-
methyl 2-hydroxy-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]benzoate
-
-
methyl 2-hydroxy-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]benzoate
-
methyl 3-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]propanoate
-
methyl 3-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]propanoate
-
methyl methanethiosulfonate
-
89% inhibition at 1 mM at pH 7.4
methyl methanethiosulfonate
-
89% inhibition at 1 mM at pH 7.4
Mg2+
-
20% inhibition at 1 mM
Mg2+
-
30% inhibition at 1 mM
Mg2+
-
40% inhibition at 1 mM
Mn2+
-
inhibition of Mg2+-dependent acrtivity
Mn2+
-
30% inhibition at 1 mM
Mn2+
-
20% inhibition at 1 mM
Mn2+
-
20% inhibition at 1 mM
N,N'-(butane-1,4-diyl)bis[4-(adamantan-2-yl)piperazine-1-carboxamide]
-
N,N'-(butane-1,4-diyl)bis[4-(adamantan-2-yl)piperazine-1-carboxamide]
-
N,N'-(butane-1,4-diyl)bis[4-(adamantan-2-yl)piperazine-1-carboxamide]
-
N,N'-1,2-phenylenebis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-1,2-phenylenebis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-1,2-phenylenebis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-1,2-phenylenebis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-1,2-phenylenebis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-1,2-phenylenebis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-1,4-phenylenebis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-1,4-phenylenebis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-1,4-phenylenebis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-bis(3,5,7-trimethyladamantan-1-yl)urea
-
N,N'-bis(3,5,7-trimethyladamantan-1-yl)urea
-
N,N'-bis(3,5,7-trimethyladamantan-1-yl)urea
-
N,N'-bis(3,5-dimethyladamantan-1-yl)urea
-
N,N'-bis(3,5-dimethyladamantan-1-yl)urea
-
N,N'-bis(3,5-dimethyladamantan-1-yl)urea
-
N,N'-bis(3-chloroadamantan-1-yl)urea
-
N,N'-bis(3-chloroadamantan-1-yl)urea
-
N,N'-bis(3-chloroadamantan-1-yl)urea
-
N,N'-bis(3-ethyladamantan-1-yl)urea
-
N,N'-bis(3-ethyladamantan-1-yl)urea
-
N,N'-bis(3-ethyladamantan-1-yl)urea
-
N,N'-bis(3-methyladamantan-1-yl)urea
-
N,N'-bis(3-methyladamantan-1-yl)urea
-
N,N'-bis(3-methyladamantan-1-yl)urea
-
N,N'-bis-(3,4-dichlorophenyl)urea
-
-
N,N'-bis-(3,4-dichlorophenyl)urea
-
-
N,N'-bis[(adamantan-1-yl)methyl]urea
-
N,N'-bis[(adamantan-1-yl)methyl]urea
-
N,N'-bis[(adamantan-1-yl)methyl]urea
-
N,N'-butane-1,4-diylbis[N'-(3,5-dimethyladamantan-1-yl)urea]
-
N,N'-butane-1,4-diylbis[N'-(3,5-dimethyladamantan-1-yl)urea]
-
N,N'-butane-1,4-diylbis[N'-(3,5-dimethyladamantan-1-yl)urea]
-
N,N'-butane-1,4-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-butane-1,4-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-butane-1,4-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-butane-1,4-diylbis[N'-(3-ethyladamantan-1-yl)urea]
-
N,N'-butane-1,4-diylbis[N'-(3-ethyladamantan-1-yl)urea]
-
N,N'-butane-1,4-diylbis[N'-(3-ethyladamantan-1-yl)urea]
-
N,N'-butane-1,4-diylbis[N'-[(3,5-dimethyladamantan-1-yl)methyl]urea]
-
N,N'-butane-1,4-diylbis[N'-[(3,5-dimethyladamantan-1-yl)methyl]urea]
-
N,N'-butane-1,4-diylbis[N'-[(3,5-dimethyladamantan-1-yl)methyl]urea]
-
N,N'-butane-1,4-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-butane-1,4-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-butane-1,4-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-butane-1,4-diylbis[N'-[1-(adamantan-1-yl)-2-methylpropan-2-yl]urea]
-
N,N'-butane-1,4-diylbis[N'-[1-(adamantan-1-yl)-2-methylpropan-2-yl]urea]
-
N,N'-butane-1,4-diylbis[N'-[1-(adamantan-1-yl)-2-methylpropan-2-yl]urea]
-
N,N'-butane-1,4-diylbis[N'-[2-(adamantan-1-yl)-2-phenylethyl]urea]
-
N,N'-butane-1,4-diylbis[N'-[2-(adamantan-1-yl)-2-phenylethyl]urea]
-
N,N'-butane-1,4-diylbis[N'-[2-(adamantan-1-yl)-2-phenylethyl]urea]
-
N,N'-butane-1,4-diylbis[N'-[2-(adamantan-1-yl)ethyl]urea]
-
N,N'-butane-1,4-diylbis[N'-[2-(adamantan-1-yl)ethyl]urea]
-
N,N'-butane-1,4-diylbis[N'-[2-(adamantan-1-yl)ethyl]urea]
-
N,N'-butane-1,4-diylbis[N'-[2-(adamantan-1-yl)pentyl]urea]
-
N,N'-butane-1,4-diylbis[N'-[2-(adamantan-1-yl)pentyl]urea]
-
N,N'-butane-1,4-diylbis[N'-[2-(adamantan-1-yl)pentyl]urea]
-
N,N'-butane-1,4-diylbis[N'-[4-(adamantan-1-yl)phenyl]urea]
-
N,N'-butane-1,4-diylbis[N'-[4-(adamantan-1-yl)phenyl]urea]
-
N,N'-butane-1,4-diylbis[N'-[4-(adamantan-1-yl)phenyl]urea]
-
N,N'-decane-1,10-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-decane-1,10-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-decane-1,10-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-dicyclohexylurea
-
0.01 mM, 30% inhibition
N,N'-dicyclohexylurea
DCU
N,N'-dicyclohexylurea
-
specific inhibitor, decreases the enzyme activity and blood pressure in spontaneously hypertensive rats, IC50 with different substrates, overview
N,N'-ethane-1,2-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-ethane-1,2-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-ethane-1,2-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-ethane-1,2-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-ethane-1,2-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-ethane-1,2-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-heptane-1,7-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-heptane-1,7-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-heptane-1,7-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-heptane-1,7-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-heptane-1,7-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-heptane-1,7-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-hexane-1,6-diylbis(N'-[3-[(adamantan-1-yl)oxy]propyl]urea)
-
N,N'-hexane-1,6-diylbis(N'-[3-[(adamantan-1-yl)oxy]propyl]urea)
-
N,N'-hexane-1,6-diylbis(N'-[3-[(adamantan-1-yl)oxy]propyl]urea)
-
N,N'-hexane-1,6-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-hexane-1,6-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-hexane-1,6-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-hexane-1,6-diylbis[N'-(3-ethyladamantan-1-yl)urea]
-
N,N'-hexane-1,6-diylbis[N'-(3-ethyladamantan-1-yl)urea]
-
N,N'-hexane-1,6-diylbis[N'-(3-ethyladamantan-1-yl)urea]
-
N,N'-hexane-1,6-diylbis[N'-[(3,5-dimethyladamantan-1-yl)methyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[(3,5-dimethyladamantan-1-yl)methyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[(3,5-dimethyladamantan-1-yl)methyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[1-(adamantan-1-yl)ethyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[1-(adamantan-1-yl)ethyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[1-(adamantan-1-yl)ethyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)-2-methylpropyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)-2-methylpropyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)-2-methylpropyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)-2-phenylethyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)-2-phenylethyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)-2-phenylethyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)butyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)butyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)butyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)ethyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)ethyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)ethyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)pentyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)pentyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)pentyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[4-(adamantan-1-yl)phenyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[4-(adamantan-1-yl)phenyl]urea]
-
N,N'-hexane-1,6-diylbis[N'-[4-(adamantan-1-yl)phenyl]urea]
-
N,N'-octane-1,8-diylbis(N'-[3-[(adamantan-1-yl)oxy]propyl]urea)
-
N,N'-octane-1,8-diylbis(N'-[3-[(adamantan-1-yl)oxy]propyl]urea)
-
N,N'-octane-1,8-diylbis(N'-[3-[(adamantan-1-yl)oxy]propyl]urea)
-
N,N'-octane-1,8-diylbis[N'-(3,5-dimethyladamantan-1-yl)urea]
-
N,N'-octane-1,8-diylbis[N'-(3,5-dimethyladamantan-1-yl)urea]
-
N,N'-octane-1,8-diylbis[N'-(3,5-dimethyladamantan-1-yl)urea]
-
N,N'-octane-1,8-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-octane-1,8-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-octane-1,8-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-octane-1,8-diylbis[N'-[(3,5-dimethyladamantan-1-yl)methyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[(3,5-dimethyladamantan-1-yl)methyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[(3,5-dimethyladamantan-1-yl)methyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)-2-methylpropyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)-2-methylpropyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)-2-methylpropyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)-2-phenylethyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)-2-phenylethyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)-2-phenylethyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)ethyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)ethyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)ethyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)pentyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)pentyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)pentyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[4-(adamantan-1-yl)phenyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[4-(adamantan-1-yl)phenyl]urea]
-
N,N'-octane-1,8-diylbis[N'-[4-(adamantan-1-yl)phenyl]urea]
-
N,N'-pentane-1,5-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-pentane-1,5-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-pentane-1,5-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-pentane-1,5-diylbis[N'-(3-ethyladamantan-1-yl)urea]
-
N,N'-pentane-1,5-diylbis[N'-(3-ethyladamantan-1-yl)urea]
-
N,N'-pentane-1,5-diylbis[N'-(3-ethyladamantan-1-yl)urea]
-
N,N'-pentane-1,5-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-pentane-1,5-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-pentane-1,5-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-propane-1,3-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-propane-1,3-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-propane-1,3-diylbis[N'-(3-chloroadamantan-1-yl)urea]
-
N,N'-propane-1,3-diylbis[N'-(3-ethyladamantan-1-yl)urea]
-
N,N'-propane-1,3-diylbis[N'-(3-ethyladamantan-1-yl)urea]
-
N,N'-propane-1,3-diylbis[N'-(3-ethyladamantan-1-yl)urea]
-
N,N'-propane-1,3-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-propane-1,3-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-propane-1,3-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-undecane-1,11-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-undecane-1,11-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-undecane-1,11-diylbis[N'-[(adamantan-1-yl)methyl]urea]
-
N,N'-[1,4-phenylenebis(methylene)]bis[N'-(3,5-dimethyladamantan-1-yl)urea]
-
N,N'-[1,4-phenylenebis(methylene)]bis[N'-(3,5-dimethyladamantan-1-yl)urea]
-
N,N'-[1,4-phenylenebis(methylene)]bis[N'-(3,5-dimethyladamantan-1-yl)urea]
-
N,N-dicyclohexylurea
i.e. N,N-dicyclohexylurea
N,N-dicyclohexylurea
-
i.e. N,N-dicyclohexylurea
N,N-dicyclohexylurea
-
i.e. N,N-dicyclohexylurea
N-(1,2-benzoxazol-3-yl)-3-methyl-3-phenylpiperidine-1-carboxamide
-
N-(1,2-benzoxazol-3-yl)-3-methyl-3-phenylpiperidine-1-carboxamide
-
N-(1-acetylpiperidin-4-yl)-2-(tricyclo[3.3.1.13,7]dec-1-yl)acetamide
-
-
N-(1-acetylpiperidin-4-yl)-2-(tricyclo[3.3.1.13,7]dec-1-yl)acetamide
-
N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
-
-
N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
-
-
N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
-
-
N-(2,2-diphenyl-ethyl)-nicotinamide
-
N-(2,2-diphenyl-ethyl)-nicotinamide
-
N-(2,3-dihydro-1H-inden-1-yl)-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
N-(2,3-dihydro-1H-inden-1-yl)-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
N-(2,4-dichlorobenzyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
-
N-(2,4-dichlorobenzyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
-
N-(2,4-dichlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
97% inhibition at 200 nM
N-(2,4-dichlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
N-(2,4-dichlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
-
N-(2,4-dichlorobenzyl)-3-methyl-3-phenylpiperidine-1-carboxamide
-
N-(2,4-dichlorobenzyl)-3-methyl-3-phenylpiperidine-1-carboxamide
-
N-(2,4-dichlorobenzyl)-4-(4-fluorophenoxy)piperidine-1-carboxamide
-
N-(2,4-dichlorobenzyl)-4-(4-fluorophenoxy)piperidine-1-carboxamide
-
N-(2,4-dichlorobenzyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
-
N-(2,4-dichlorobenzyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
-
N-(2,4-dichlorobenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
-
N-(2,4-dichlorobenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
-
N-(2,4-dichlorobenzyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
-
N-(2,4-dichlorobenzyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
-
N-(2-chloro-4-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-(2-chloro-4-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-(2-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-(2-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-(2-oxoadamantan-1-yl)-N'-1,3,5-triazatricyclo[3.3.1.13,7]decan-7-ylurea
-
N-(2-oxoadamantan-1-yl)-N'-1,3,5-triazatricyclo[3.3.1.13,7]decan-7-ylurea
-
N-(2-oxoadamantan-1-yl)-N'-1,3,5-triazatricyclo[3.3.1.13,7]decan-7-ylurea
-
N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide
-
N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide
-
N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
-
N-(3,3-diphenyl-propyl)-2-pyridine-3-ylacetamide
-
N-(3,3-diphenyl-propyl)-2-pyridine-3-ylacetamide
-
N-(3,3-diphenyl-propyl)-isonicotinamide
-
N-(3,3-diphenyl-propyl)-isonicotinamide
-
N-(3,3-diphenyl-propyl)-nicotinamide
-
N-(3,3-diphenyl-propyl)-nicotinamide
-
N-(3,3-diphenylpropyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
-
N-(3,3-diphenylpropyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
-
N-(3,3-diphenylpropyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
-
N-(3,3-diphenylpropyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
-
N-(3,3-diphenylpropyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
-
N-(3,3-diphenylpropyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
-
N-(3,3-diphenylpropyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
-
N-(3,3-diphenylpropyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
-
N-(3,3-diphenylpropyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
-
N-(3,5,7-trimethyladamantan-1-yl)-4-([[(3,5,7-trimethyladamantan-1-yl)carbamoyl]amino]methyl)piperidine-1-carboxamide
-
N-(3,5,7-trimethyladamantan-1-yl)-4-([[(3,5,7-trimethyladamantan-1-yl)carbamoyl]amino]methyl)piperidine-1-carboxamide
-
N-(3,5,7-trimethyladamantan-1-yl)-4-([[(3,5,7-trimethyladamantan-1-yl)carbamoyl]amino]methyl)piperidine-1-carboxamide
-
N-(3,5-dimethyladamantan-1-yl)-N'-(1-propanoylpiperidin-4-yl)urea
-
N-(3,5-dimethyladamantan-1-yl)-N'-(1-propanoylpiperidin-4-yl)urea
-
N-(3,5-dimethyladamantan-1-yl)-N'-(1-propanoylpiperidin-4-yl)urea
-
N-(3,5-dimethyladamantan-1-yl)-N'-(3,5,7-trimethyladamantan-1-yl)urea
-
N-(3,5-dimethyladamantan-1-yl)-N'-(3,5,7-trimethyladamantan-1-yl)urea
-
N-(3,5-dimethyladamantan-1-yl)-N'-(3,5,7-trimethyladamantan-1-yl)urea
-
N-(3,5-dimethyladamantan-1-yl)-N'-1,3,5-triazatricyclo[3.3.1.13,7]decan-7-ylurea
-
N-(3,5-dimethyladamantan-1-yl)-N'-1,3,5-triazatricyclo[3.3.1.13,7]decan-7-ylurea
-
N-(3,5-dimethyladamantan-1-yl)-N'-1,3,5-triazatricyclo[3.3.1.13,7]decan-7-ylurea
-
N-(3,5-dimethyladamantan-1-yl)-N'-[(3-ethyladamantan-1-yl)methyl]urea
-
N-(3,5-dimethyladamantan-1-yl)-N'-[(3-ethyladamantan-1-yl)methyl]urea
-
N-(3,5-dimethyladamantan-1-yl)-N'-[(3-ethyladamantan-1-yl)methyl]urea
-
N-(3,5-dimethyladamantan-1-yl)-N'-[4-([[(3,5-dimethyladamantan-1-yl)carbamoyl]amino]methyl)phenyl]urea
-
N-(3,5-dimethyladamantan-1-yl)-N'-[4-([[(3,5-dimethyladamantan-1-yl)carbamoyl]amino]methyl)phenyl]urea
-
N-(3,5-dimethyladamantan-1-yl)-N'-[4-([[(3,5-dimethyladamantan-1-yl)carbamoyl]amino]methyl)phenyl]urea
-
N-(3-ethyladamantan-1-yl)-N'-(1-propanoylpiperidin-4-yl)urea
-
N-(3-ethyladamantan-1-yl)-N'-(1-propanoylpiperidin-4-yl)urea
-
N-(3-ethyladamantan-1-yl)-N'-(1-propanoylpiperidin-4-yl)urea
-
N-(3-ethyladamantan-1-yl)-N'-1,3,5-triazatricyclo[3.3.1.13,7]decan-7-ylurea
-
-
N-(3-ethyladamantan-1-yl)-N'-1,3,5-triazatricyclo[3.3.1.13,7]decan-7-ylurea
-
-
N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-2-(tricyclo[3.3.1.13,7]dec-1-yl)acetamide
-
-
N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-2-(tricyclo[3.3.1.13,7]dec-1-yl)acetamide
-
N-(3-phenyl-propyl)-nicotinamide
-
N-(3-phenyl-propyl)-nicotinamide
-
N-(4,4-diphenyl-butyl)-nicotinamide
-
N-(4,4-diphenyl-butyl)-nicotinamide
-
N-(4-bromo-2-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-(4-bromo-2-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-(4-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-(4-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-(4-chlorophenyl)-3-(2-cyanoethyl)-3-phenylpiperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-(2-cyanoethyl)-3-phenylpiperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-(2-hydroxyethyl)-3-phenylpiperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-(2-hydroxyethyl)-3-phenylpiperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-(3-hydroxypropyl)-3-phenylpiperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-(3-hydroxypropyl)-3-phenylpiperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-methyl-3-phenylpiperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-methyl-3-phenylpiperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-phenyl-3-[2-(1H-tetrazol-5-yl)ethyl]piperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-phenyl-3-[2-(1H-tetrazol-5-yl)ethyl]piperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-[2-(dimethylamino)ethyl]-3-phenylpiperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-[2-(dimethylamino)ethyl]-3-phenylpiperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-[2-oxo-2-(1H-tetrazol-5-ylamino)ethyl]-3-phenylpiperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-[2-oxo-2-(1H-tetrazol-5-ylamino)ethyl]-3-phenylpiperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-[3-(diethylamino)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-[3-(diethylamino)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-[3-(methylamino)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-[3-(methylamino)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-[3-(morpholin-4-yl)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-[3-(morpholin-4-yl)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-[3-oxo-3-(1H-tetrazol-5-ylamino)propyl]-3-phenylpiperidine-1-carboxamide
-
N-(4-chlorophenyl)-3-[3-oxo-3-(1H-tetrazol-5-ylamino)propyl]-3-phenylpiperidine-1-carboxamide
-
N-(4-[(3-phenyloxiran-2-yl)carbonyl]phenyl)acetamide
-
IC50 is 0.00014 mM
N-(4-[(3-phenyloxiran-2-yl)carbonyl]phenyl)acetamide
-
IC50 is 0.0017 mM
N-(biphenyl-3-yl)-3-methyl-3-phenylpiperidine-1-carboxamide
-
N-(biphenyl-3-yl)-3-methyl-3-phenylpiperidine-1-carboxamide
-
N-adamantan-1-yl-N'-(3,5,7-trimethyladamantan-1-yl)urea
-
N-adamantan-1-yl-N'-(3,5,7-trimethyladamantan-1-yl)urea
-
N-adamantan-1-yl-N'-(3,5,7-trimethyladamantan-1-yl)urea
-
N-adamantan-1-yl-N'-(3,5-dimethyladamantan-1-yl)urea
-
N-adamantan-1-yl-N'-(3,5-dimethyladamantan-1-yl)urea
-
N-adamantan-1-yl-N'-(3,5-dimethyladamantan-1-yl)urea
-
N-adamantan-1-yl-N'-(5-hydroxypentyl)urea
-
N-adamantan-1-yl-N'-(5-hydroxypentyl)urea
-
N-adamantan-1-yl-N'-(5-hydroxypentyl)urea
-
N-adamantan-1-yl-N'-(5-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]pentyl)urea
-
N-adamantan-1-yl-N'-(5-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]pentyl)urea
-
N-adamantan-1-yl-N'-(5-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]pentyl)urea
-
N-adamantan-1-yl-N'-[(3-ethyladamantan-1-yl)methyl]urea
-
N-adamantan-1-yl-N'-[(3-ethyladamantan-1-yl)methyl]urea
-
N-adamantan-1-yl-N'-[(3-ethyladamantan-1-yl)methyl]urea
-
N-adamantan-1-yl-N'-[5-(2-hydroxyethoxy)pentyl]urea
-
N-adamantan-1-yl-N'-[5-(2-hydroxyethoxy)pentyl]urea
-
N-adamantan-1-yl-N'-[5-(2-hydroxyethoxy)pentyl]urea
-
N-adamantan-1-yl-N'-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]urea
AEPU, a tight binding inhibitor of enzyme sEH
N-adamantan-1-yl-N'-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]urea
AEPU, a tight binding inhibitor of enzyme sEH
N-adamantan-1-yl-N'-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]urea
AEPU, a tight binding inhibitor of enzyme sEH
N-adamantan-1-yl-N'-[5-[2-(2-hydroxyethoxy)ethoxy]pentyl]urea
-
N-adamantan-1-yl-N'-[5-[2-(2-hydroxyethoxy)ethoxy]pentyl]urea
-
N-adamantan-1-yl-N'-[5-[2-(2-hydroxyethoxy)ethoxy]pentyl]urea
-
N-adamantyl-N'-cyclohexylurea
i.e. N-adamantyl-N'-cyclohexylurea, strong inhibition
N-adamantyl-N'-cyclohexylurea
-
N-adamantyl-N'-cyclohexylurea
-
N-benzyl-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-benzyl-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-cycloheptyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
90% inhibition at 200 nM
N-cycloheptyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
-
N-cycloheptyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
-
N-cyclohexyl-N'-4-chlorophenylurea
-
-
N-cyclohexyl-N'-4-chlorophenylurea
-
-
N-cyclohexyl-N'-decylurea
-
-
N-cyclohexyl-N'-decylurea
i.e. CDU, binding structure, overview
N-cyclopentyl-N'-dodecylurea
-
-
N-cyclopentyl-N'-dodecylurea
-
-
N-ethylmaleimide
-
98% inhibition at 1 mM at pH 7.4
N-ethylmaleimide
-
21% inhibition at 1 mM at pH 7.4
N-Phenylmaleimide
-
97% inhibition at 1 mM at pH 7.4
N-Phenylmaleimide
-
60% inhibition at 1 mM at pH 7.4
N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-4-methylpiperazine-1-carboxamide
-
N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-4-methylpiperazine-1-carboxamide
-
N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]piperidine-1-carboxamide
-
N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]piperidine-1-carboxamide
-
N-[(3'-chlorobiphenyl-4-yl)methyl]-3-methyl-3-phenylpiperidine-1-carboxamide
-
N-[(3'-chlorobiphenyl-4-yl)methyl]-3-methyl-3-phenylpiperidine-1-carboxamide
-
N-[(3,5-dimethyladamantan-1-yl)methyl]-N'-(3,5,7-trimethyladamantan-1-yl)urea
-
N-[(3,5-dimethyladamantan-1-yl)methyl]-N'-(3,5,7-trimethyladamantan-1-yl)urea
-
N-[(3,5-dimethyladamantan-1-yl)methyl]-N'-(3,5,7-trimethyladamantan-1-yl)urea
-
N-[(3-ethyladamantan-1-yl)methyl]-N'-(1-propanoylpiperidin-4-yl)urea
-
N-[(3-ethyladamantan-1-yl)methyl]-N'-(1-propanoylpiperidin-4-yl)urea
-
N-[(3-ethyladamantan-1-yl)methyl]-N'-(1-propanoylpiperidin-4-yl)urea
-
N-[(3-ethyladamantan-1-yl)methyl]-N'-1,3,5-triazatricyclo[3.3.1.13,7]decan-7-ylurea
-
N-[(3-ethyladamantan-1-yl)methyl]-N'-1,3,5-triazatricyclo[3.3.1.13,7]decan-7-ylurea
-
N-[(3-ethyladamantan-1-yl)methyl]-N'-1,3,5-triazatricyclo[3.3.1.13,7]decan-7-ylurea
-
N-[(adamantan-1-yl)carbamoyl]-beta-alanine
-
N-[(adamantan-1-yl)carbamoyl]-beta-alanine
-
N-[(adamantan-1-yl)carbamoyl]-beta-alanine
-
N-[(adamantan-1-yl)methyl]-2-[3-(adamantan-1-yl)propyl]hydrazine-1-carboxamide
-
N-[(adamantan-1-yl)methyl]-2-[3-(adamantan-1-yl)propyl]hydrazine-1-carboxamide
-
N-[(adamantan-1-yl)methyl]-2-[3-(adamantan-1-yl)propyl]hydrazine-1-carboxamide
-
N-[(adamantan-1-yl)methyl]-4-[([[(adamantan-1-yl)methyl]carbamoyl]amino)methyl]piperidine-1-carboxamide
-
N-[(adamantan-1-yl)methyl]-4-[([[(adamantan-1-yl)methyl]carbamoyl]amino)methyl]piperidine-1-carboxamide
-
N-[(adamantan-1-yl)methyl]-4-[([[(adamantan-1-yl)methyl]carbamoyl]amino)methyl]piperidine-1-carboxamide
-
N-[(adamantan-1-yl)methyl]-N'-(1-propanoylpiperidin-4-yl)urea
-
N-[(adamantan-1-yl)methyl]-N'-(1-propanoylpiperidin-4-yl)urea
-
N-[(adamantan-1-yl)methyl]-N'-(1-propanoylpiperidin-4-yl)urea
-
N-[(adamantan-1-yl)methyl]-N'-[2-(adamantan-1-yl)pentyl]urea
-
N-[(adamantan-1-yl)methyl]-N'-[2-(adamantan-1-yl)pentyl]urea
-
N-[(adamantan-1-yl)methyl]-N'-[2-(adamantan-1-yl)pentyl]urea
-
N-[(adamantan-1-yl)methyl]-N'-[4-(adamantan-1-yl)phenyl]urea
-
N-[(adamantan-1-yl)methyl]-N'-[4-(adamantan-1-yl)phenyl]urea
-
N-[(adamantan-1-yl)methyl]-N'-[4-(adamantan-1-yl)phenyl]urea
-
N-[1-(adamantan-1-yl)ethyl]-N'-(3,5,7-trimethyladamantan-1-yl)urea
-
N-[1-(adamantan-1-yl)ethyl]-N'-(3,5,7-trimethyladamantan-1-yl)urea
-
N-[1-(adamantan-1-yl)ethyl]-N'-(3,5,7-trimethyladamantan-1-yl)urea
-
N-[1-(adamantan-1-yl)ethyl]-N'-[(3-ethyladamantan-1-yl)methyl]urea
-
N-[1-(adamantan-1-yl)ethyl]-N'-[(3-ethyladamantan-1-yl)methyl]urea
-
N-[1-(adamantan-1-yl)ethyl]-N'-[(3-ethyladamantan-1-yl)methyl]urea
-
N-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-2-[4-(trifluoromethoxy)phenyl]acetamide
-
N-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-2-[4-(trifluoromethoxy)phenyl]acetamide
-
-
N-[2-(adamantan-1-yl)butyl]-N'-(3,5,7-trimethyladamantan-1-yl)urea
-
N-[2-(adamantan-1-yl)butyl]-N'-(3,5,7-trimethyladamantan-1-yl)urea
-
N-[2-(adamantan-1-yl)butyl]-N'-(3,5,7-trimethyladamantan-1-yl)urea
-
N-[2-(adamantan-1-yl)butyl]-N'-(3,5-dimethyladamantan-1-yl)urea
-
N-[2-(adamantan-1-yl)butyl]-N'-(3,5-dimethyladamantan-1-yl)urea
-
N-[2-(adamantan-1-yl)butyl]-N'-(3,5-dimethyladamantan-1-yl)urea
-
N-[2-(adamantan-1-yl)ethyl]-N'-[(adamantan-1-yl)methyl]urea
-
N-[2-(adamantan-1-yl)ethyl]-N'-[(adamantan-1-yl)methyl]urea
-
N-[2-(adamantan-1-yl)ethyl]-N'-[(adamantan-1-yl)methyl]urea
-
N-[2-(adamantan-1-yl)pentyl]-N'-(3-chloroadamantan-1-yl)urea
-
N-[2-(adamantan-1-yl)pentyl]-N'-(3-chloroadamantan-1-yl)urea
-
N-[2-(adamantan-1-yl)pentyl]-N'-(3-chloroadamantan-1-yl)urea
-
N-[2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-[2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-[2-(trifluoromethoxy)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-[2-(trifluoromethoxy)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-[2-chloro-4-(1H-tetrazol-5-yl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-[2-chloro-4-(1H-tetrazol-5-yl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-[2-chloro-4-(methylsulfamoyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-[2-chloro-4-(methylsulfamoyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-[2-chloro-4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-[2-chloro-4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-[3,3-bis-(4-fluorophenyl)-propyl]-2-(2,2,2-trifluoro-ethoxy)-isonicotinamide
-
N-[3,3-bis-(4-fluorophenyl)-propyl]-2-(2,2,2-trifluoro-ethoxy)-isonicotinamide
-
N-[3,3-bis-(4-fluorophenyl)-propyl]-4-methanesulfonyl-benzamide
-
N-[3,3-bis-(4-fluorophenyl)-propyl]-4-methanesulfonyl-benzamide
-
N-[3,3-bis-(4-fluorophenyl)-propyl]-6-(2,2,2-trifluoro-ethoxy)-nicotinamide
-
N-[3,3-bis-(4-fluorophenyl)-propyl]-6-(2,2,2-trifluoro-ethoxy)-nicotinamide
-
N-[3,3-bis-(4-fluorophenyl)-propyl]-6-hydroxy-nicotinamide
-
N-[3,3-bis-(4-fluorophenyl)-propyl]-6-hydroxy-nicotinamide
-
N-[3,3-bis-(4-fluorophenyl)-propyl]-benzamide
-
N-[3,3-bis-(4-fluorophenyl)-propyl]-benzamide
-
N-[3,3-bis-(4-fluorophenyl)-propyl]-nicotinamide
-
N-[3,3-bis-(4-fluorophenyl)-propyl]-nicotinamide
-
N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-4-methanesulfonyl-benzamide
-
N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-4-methanesulfonyl-benzamide
-
N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-(2,2,2-trifluoro-ethoxy)-nicotinamide
-
N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-(2,2,2-trifluoro-ethoxy)-nicotinamide
-
N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-nicotinamide
-
N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-nicotinamide
-
N-[3-[2-(4-chlorophenyl)ethyl]benzyl]-3-methyl-3-phenylpiperidine-1-carboxamide
-
N-[3-[2-(4-chlorophenyl)ethyl]benzyl]-3-methyl-3-phenylpiperidine-1-carboxamide
-
N-[4-(1H-indol-5-yl)benzyl]-3-methyl-3-phenylpiperidine-1-carboxamide
-
N-[4-(1H-indol-5-yl)benzyl]-3-methyl-3-phenylpiperidine-1-carboxamide
-
N-[4-(3-benzoyloxiran-2-yl)phenyl]acetamide
-
IC50 is 0.00027 mM
N-[4-(3-benzoyloxiran-2-yl)phenyl]acetamide
-
IC50 is 0.00022 mM
N-[4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-[4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-[4-chloro-2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-[4-chloro-2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-N'-(4-hydroxyadamantan-1-yl)urea
-
N-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-N'-(4-hydroxyadamantan-1-yl)urea
-
N-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-N'-(4-hydroxyadamantan-1-yl)urea
-
N-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-N'-(4-oxoadamantan-1-yl)urea
-
N-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-N'-(4-oxoadamantan-1-yl)urea
-
N-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-N'-(4-oxoadamantan-1-yl)urea
-
N-[[4'-(methylsulfonyl)biphenyl-4-yl]methyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N-[[4'-(methylsulfonyl)biphenyl-4-yl]methyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
N1,N4-bis[(adamantan-1-yl)methyl]piperazine-1,4-dicarboxamide
-
N1,N4-bis[(adamantan-1-yl)methyl]piperazine-1,4-dicarboxamide
-
N1,N4-bis[(adamantan-1-yl)methyl]piperazine-1,4-dicarboxamide
-
N1-(2,4-dichlorobenzyl)-N4-(2-methoxyethyl)piperidine-1,4-dicarboxamide
-
N1-(2,4-dichlorobenzyl)-N4-(2-methoxyethyl)piperidine-1,4-dicarboxamide
-
Ni2+
-
25% inhibition at 1 mM
Ni2+
-
40% inhibition at 1 mM
Ni2+
-
5 mM, more than 90% inhibition
Ni2+
-
20% inhibition at 1 mM
Ni2+
-
30% inhibition at 1 mM
ninhydrin
-
13% inhibition at 1 mM at pH 7.4
ninhydrin
-
12% inhibition at 1 mM at pH 7.4
p-Hydroxymercuriphenylsulfonate
-
-
p-Hydroxymercuriphenylsulfonate
-
-
p-Hydroxymercuriphenylsulfonate
-
-
p-Hydroxymercuriphenylsulfonate
-
-
p-Hydroxymercuriphenylsulfonate
-
-
Pb2+
-
inhibition of Mg2+-dependent acrtivity
Pb2+
-
20% inhibition at 1 mM
Pb2+
-
30% inhibition at 1 mM
Pb2+
-
25% inhibition at 1 mM
Pb2+
-
60% inhibition at 1 mM
peroxynitrite
causes nitration on several tyrosine residues including Tyr383 and Tyr466
peroxynitrite
causes nitration on several tyrosine residues including Tyr383 and Tyr466
phenyl(3-phenyloxiran-2-yl)methanol
-
IC50 is 0.022 mM
phenyl(3-phenyloxiran-2-yl)methanol
-
IC50 is 0.0126 mM
phenyl(3-phenyloxiran-2-yl)methanone
-
IC50 is 0.0003 mM
phenyl(3-phenyloxiran-2-yl)methanone
-
IC50 is 0.0029 mM
Phenylglyoxal
-
19% inhibition at 1 mM at pH 7.4
Phenylglyoxal
-
22% inhibition at 1 mM at pH 7.4
phenylthioisocyanate
-
54% inhibition at 1 mM at pH 7.4
phenylthioisocyanate
-
34% inhibition at 1 mM at pH 7.4
pyridine-2-carboxylic acid (3,3-diphenyl-propyl)-amide
-
pyridine-2-carboxylic acid (3,3-diphenyl-propyl)-amide
-
pyridine-3-sulfonic acid 3,3-(diphenylpropyl)-amide
-
pyridine-3-sulfonic acid 3,3-(diphenylpropyl)-amide
-
styrene oxide
-
inhibits hydration of trans-9,10-epoxystearate
substituted chalcone oxides
-
-
-
substituted chalcone oxides
-
-
-
substituted chalcone oxides
-
-
-
substituted chalcone oxides
-
-
-
substituted chalcone oxides
-
-
-
tetrahydrofuran
-
-
tetrahydrofuran
-
73% loss of activity with 1% tetrahydrofuran, 98% loss of activity with 5% tetrahydrofuran
tetrahydrofuran
-
hydration of trans-stilbene oxide
trans-(2R,3R)-3-phenylglycidol
-
IC50 for the R-enantiomer is about 3.9 mM
trans-(2R,3R)-3-phenylglycidol
-
23% inhibition of recombinant and of native enzyme at 0.057 mM
trans-(2S,3S)-3-phenylglycidol
-
IC50 for the S-enantiomer is about 2.2 mM
trans-(2S,3S)-3-phenylglycidol
-
98% inhibition of recombinant and 85% inhibition of native enzyme at 0.057 mM
trans-4-(4-(3-adamantan-1-yl-ureido)-cyclohexyloxy)-benzoic acid
-
trans-4-(4-(3-adamantan-1-yl-ureido)-cyclohexyloxy)-benzoic acid
-
i.e. t-AUCB
trans-4-(4-(3-adamantan-1-yl-ureido)-cyclohexyloxy)-benzoic acid
i.e. t-AUCB
trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid
-
i.e. t-AUCB
trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid
-
-
trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid
i.e. t-AUCB
trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid
-
trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid
i.e. t-AUCB, causes enzyme inhibition that is protective against ischemia-reperfusion injury, reversible by 14,15-epoxyeicosatrienoic acid, mechanisms, overview
trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid
i.e. tAUCB, shows beneficial effects in cardiac hypertrophy, evaluation in a clinically relevant murine model of myocardial infarction, overview
trans-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
-
potent sEH inhibitor
trans-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
-
potent sEH inhibitor
trans-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
-
potent sEH inhibitor
trans-4-[4-(3-adamantan-1-ylureido)-cyclohexyloxy]-benzoic acid
t-AUCB, a tight binding inhibitor of enzyme sEH
trans-4-[4-(3-adamantan-1-ylureido)-cyclohexyloxy]-benzoic acid
t-AUCB
trans-4-[4-(3-adamantan-1-ylureido)-cyclohexyloxy]-benzoic acid
i.e. t-AUCB
trans-4-[4-(3-adamantan-1-ylureido)-cyclohexyloxy]-benzoic acid
t-AUCB, a tight binding inhibitor of enzyme sEH
trans-4-[4-(3-adamantan-1-ylureido)-cyclohexyloxy]-benzoic acid
t-AUCB, a tight binding inhibitor of enzyme sEH
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]-benzoic acid
-
-
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]-benzoic acid
-
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]-benzoic acid
-
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]-benzoic acid
i.e. t-AUCB
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
-
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
-
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
-
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
-
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
-
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
-
-
trans-4-[4-[3-(4-trifluoromethoxyphenyl)-ureido]-cyclohexyloxy]benzoic acid
-
trans-4-[4-[3-(4-trifluoromethoxyphenyl)-ureido]-cyclohexyloxy]benzoic acid
-
-
trichloropropene oxide
-
-
trichloropropene oxide
-
-
trichloropropene oxide
-
weak inhibitor
Urea
-
-
Zn2+
-
inhibition of phosphatase activity and epoxide hydrolase activity
Zn2+
-
noncompetitive, inhibits epoxide hydrolase and phosphatase activities, allosteric mechanism
Zn2+
-
complete inhibition at 1 mM
Zn2+
-
complete inhibition at 1 mM
Zn2+
-
5 mM, more than 90% inhibition
Zn2+
-
over 95% inhibition at 1 mM
Zn2+
-
40% inhibition at 1 mM
[(5-[[(adamantan-1-yl)carbamoyl]amino]pentyl)oxy]acetic acid
-
[(5-[[(adamantan-1-yl)carbamoyl]amino]pentyl)oxy]acetic acid
-
[(5-[[(adamantan-1-yl)carbamoyl]amino]pentyl)oxy]acetic acid
-
[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]acetic acid
-
[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]acetic acid
-
[2-[(5-[[(adamantan-1-yl)carbamoyl]amino]pentyl)oxy]ethoxy]acetic acid
-
[2-[(5-[[(adamantan-1-yl)carbamoyl]amino]pentyl)oxy]ethoxy]acetic acid
-
[2-[(5-[[(adamantan-1-yl)carbamoyl]amino]pentyl)oxy]ethoxy]acetic acid
-
[3-(2-naphthyl)oxiran-2-yl](4-nitrophenyl)methanone
-
IC50 is 0.00016 mM
[3-(2-naphthyl)oxiran-2-yl](4-nitrophenyl)methanone
-
IC50 is 0.00013 mM
[3-(2-naphthyl)oxiran-2-yl](phenyl)methanol
-
IC50 is 0.00072 mM
[3-(2-naphthyl)oxiran-2-yl](phenyl)methanol
-
IC50 is 0.00051 mM
[3-(2-naphthyl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.0002 mM; IC50 is 0.00085 mM
[3-(2-naphthyl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.00014 mM; IC50 is 0.00049 mM
[3-(4-bromophenyl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.0002 mM
[3-(4-bromophenyl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.0007 mM
[3-(4-butylphenyl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.00015 mM
[3-(4-butylphenyl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.00015 mM
[3-(4-fluorophenyl)oxiran-2-yl](phenyl)methanol
-
IC50 is 0.018 mM
[3-(4-fluorophenyl)oxiran-2-yl](phenyl)methanol
-
IC50 is 0.072 mM
[3-(4-fluorophenyl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.0003 mM
[3-(4-fluorophenyl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.0013 mM
[3-(4-heptylphenyl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.00048 mM
[3-(4-heptylphenyl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.00065 mM
[3-(4-isopropylphenyl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.00048 mM
[3-(4-isopropylphenyl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.00047 mM
[3-(4-methoxyphenyl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.00011 mM
[3-(4-methoxyphenyl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.0002 mM
[3-(4-methylphenyl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.00036 mM
[3-(4-methylphenyl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.0019 mM
[3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanol
-
IC50 is 0.028 mM
[3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanol
-
IC50 is 0.0037 mM
[3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.00063 mM
[3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.0018 mM
[3-(4-phenoxycyclohexa-1,5-dien-1-yl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.00051 mM
[3-(4-phenoxycyclohexa-1,5-dien-1-yl)oxiran-2-yl](phenyl)methanone
-
IC50 is 0.00014 mM
[4-(allyloxy)phenyl](3-phenyloxiran-2-yl)methanone
-
IC50 is 0.00014 mM
[4-(allyloxy)phenyl](3-phenyloxiran-2-yl)methanone
-
IC50 is 0.0014 mM
[4-(bromomethyl)phenyl][3-(2-naphthyl)oxiran-2-yl]methanone
-
IC50 is 0.00016 mM
[4-(bromomethyl)phenyl][3-(2-naphthyl)oxiran-2-yl]methanone
-
IC50 is 0.00011 mM
[6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl][4-(trifluoromethyl)phenyl]methanone
-
[6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl][4-(trifluoromethyl)phenyl]methanone
-
additional information
-
poor or no inhibition by tartaric acid, sodium fluoride, and sodium molybdate
-
additional information
-
IC50 values with different substrates and structure-activity relationships of enzyme inhibitors, development of an in vitro inhibition assay using fluorogenic substrates
-
additional information
-
most enzyme inhibitors do not influence the enzyme's phosphatase activity
-
additional information
-
irreversible inhibition mechanism of chalcone oxide derivatives, quantitative structure-activity relationship, QSAR, overview
-
additional information
-
inhibition mechanism of sulfates, sulfonates, and phosphonates
-
additional information
-
N-acetyl imidazole, N-bromosuccimide, cyclohexandione, acetaldehyde/borohydride and benzaldehyde/borohydride are poor inhibitors, no inhibition by PMSF and diisopropyl fluorophosphate, no inhibition by amino-, guanido-, or activated serine-selective reagents
-
additional information
-
QSAR and classification in a seven-discriptor model of enzyme inhibition by 348 urea-like compounds, IC50 ranging from 60 nM to 0.5 mM, overview
-
additional information
-
metal chelators like 1,10-phenanthroline, 1,7-phenanthroline, EDTA, EGTA, and dipicolinic acid preserve enzyme activity in presence of metal ions
-
additional information
-
the herb extract prepared from Sophora flavescens root afford the strongest inhibition of sEH with an IC50 of 0.00207 mg/ml, this is followed by other three extracts derived from the rhizome of Glycyrrhiza uralensis (IC50 0.0071 mg/ml), the root of Bupleurum chinense (IC50 0.00956 mg/ml), and the whole weed of Swertia pseudochinensis (IC50 0.01131 mg/ml)
-
additional information
evaluation of spirocyclic secondary amine-derived trisubstituted ureas as highly potent, bioavailable and selective soluble epoxide hydrolase inhibitors, overview
-
additional information
design and synthesis of a series of potent nicotinamide inhibitors of soluble epoxides hydrolase, structure-guided optimization, overview
-
additional information
-
design and synthesis of a series of potent nicotinamide inhibitors of soluble epoxides hydrolase, structure-guided optimization, overview
-
additional information
-
sEH inhibition has antihypertensive and antiinflammatory actions, presumably due to the increased bioavailability of endogenous EETs and other epoxylipids, and several potent sEH inhibitors are developed and tested in animal models of cardiovascular disease including hypertension, cardiac hypertrophy, and ischemia/reperfusion injury
-
additional information
inhibitor screening and structure-function analysis, overview
-
additional information
synthesis and structure-based optimization of arylamides sEH inhibitors based on the solid-state costructure of N-(3,3-diphenyl-propyl)-nicotinamide, overview. Assessment of inhibitor stability in liver microsomes, overview
-
additional information
-
synthesis and structure-based optimization of arylamides sEH inhibitors based on the solid-state costructure of N-(3,3-diphenyl-propyl)-nicotinamide, overview. Assessment of inhibitor stability in liver microsomes, overview
-
additional information
-
no inhibition by sunitinib, another vascular endothelial growth factor receptor. The classical sEH inhibitors do not cause growth inhibition and apoptosis and do not synergize with sorafenib
-
additional information
sEH inhibitors are developed to enhance the cardiovascular actions of epoxyeicosatrienoic acids, treatment potentials, cardiovascular therapeutic effects, antihypertensive effects, kidney-protective properties, cardiac-protective properties, and protection against ischaemic stroke and vascular disease of sEH inhibitors, overview
-
additional information
Inhibitors of human sEH are effective drug candidates for the treatment of cardiovascular diseases, inhibitor screening with recombinant enzyme, overview
-
additional information
-
Inhibitors of human sEH are effective drug candidates for the treatment of cardiovascular diseases, inhibitor screening with recombinant enzyme, overview
-
additional information
in vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors, identification of ligands structures by mass spectrometry and NMR spectroscopy, overview
-
additional information
-
in vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors, identification of ligands structures by mass spectrometry and NMR spectroscopy, overview
-
additional information
inhibitory potency and metabolic stability of adamantyl ureas and diureas bearing substituents in bridgehead positions of adamantane and/or spacers between urea groups and adamantane group. Comparison of the effects of the inhibitors on human, rat, and murine enzymes, overview
-
additional information
-
inhibitory potency and metabolic stability of adamantyl ureas and diureas bearing substituents in bridgehead positions of adamantane and/or spacers between urea groups and adamantane group. Comparison of the effects of the inhibitors on human, rat, and murine enzymes, overview
-
additional information
identification of N-ethylmethylamine as a scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening, overview. N-Ethylmethylamine is identified as a promising scaffold that forms hydrogen bonds with the catalytic residues of sEH, Asp335, Tyr383, and Tyr466. Compounds containing this scaffold are selected from a chemical library and evaluated for inhibitory potency. Enzyme-inhibitor interaction analysis
-
additional information
design and synthesis of three substituted cyclopropyl urea derivatives as strong sEH inhibitors using X-ray co-crystal structure of sEH catalytic domain and 3-[4-[(1-[[(1S,2R)-2-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid, overview. cis-Configuration together with a phenyl group result in increased human and rat sEH inhibitory activity with minimal species difference
-
additional information
-
design and synthesis of three substituted cyclopropyl urea derivatives as strong sEH inhibitors using X-ray co-crystal structure of sEH catalytic domain and 3-[4-[(1-[[(1S,2R)-2-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid, overview. cis-Configuration together with a phenyl group result in increased human and rat sEH inhibitory activity with minimal species difference
-
additional information
structural analysis of enzyme-inhibitor interactions, molecular interaction calculations, active site binding analysis, molecular docking, overview
-
additional information
interaction of the enzyme with anthocyanin derivatives, molecular docking study, molecular dynamics study, overview. The molecular docking study shows a small pocket next to the active site, which is thought to be a common allosteric site, which probably is the binding site of noncompetitive and mixed inhibitors. Moreover, the anthocyanin core is located at the hydrophobic position of the inner allosteric site. The sugar moiety interacts with amino acid residues on the outside of the allosteric site. In particular, the hydroxyl group in the sugar of the compounds is bonded with the nitrogen of Trp525. The amino acid residue may play a key role in forming hydrogen bonds with the anthocyanin glycoside. Additionally, the molecular dynamics study confirms that anthocyanin 4 can form hydrogen bonds with this residue for 10 ns
-
additional information
phytochemical constituents from Scutellaria baicalensis in soluble epoxide hydrolase inhibition: kinetics and interaction mechanism merged with simulations, overview. Extracts of Scutellaria baicalensis are separated, resulting in the isolation of thirty compounds, including six lignins, sixteen flavones, and five amides. Their structures are determined on the basis of 1H and 13C NMR and MS spectra. Molecular docking studies and inhibition mechanisms of (2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-N-(2-methylpropyl)penta-2,4-dienamide, (2E)-5-(2H-1,3-benzodioxol-5-yl)-N-(2-methylpropyl)pent-2-enamide, and (2E,6E)-7-(2H-1,3-benzodioxol-5-yl)-N-(2-methylpropyl)hepta-2,6-dienamide against sEH
-
additional information
N-benzylbenzamides are a merged scaffold for orally available dual soluble epoxide hydrolase/peroxisome proliferator-activated receptor gamma modulators, synthesis and inhibitory potencies, overview. Design of dual-target ligands that target soluble epoxide hydrolase (sEH) and the peroxisome proliferator-activated receptor type gamma (PPARgamma). Simultaneous modulation of sEH and PPARgamma can improve diabetic conditions and hypertension at once
-
additional information
-
N-benzylbenzamides are a merged scaffold for orally available dual soluble epoxide hydrolase/peroxisome proliferator-activated receptor gamma modulators, synthesis and inhibitory potencies, overview. Design of dual-target ligands that target soluble epoxide hydrolase (sEH) and the peroxisome proliferator-activated receptor type gamma (PPARgamma). Simultaneous modulation of sEH and PPARgamma can improve diabetic conditions and hypertension at once
-
additional information
synthesis and properties of 1-(R-adamant-1-yl)-3-(1-propionylpiperidin-4-yl)ureas and 4-({4-[3-(R-adamant-1-yl)ureido]cyclohexyl}oxy)benzoic acids, efficient target-oriented human soluble epoxide hydrolase inhibitors, overview. Determination of solubilities in water, lipophilicity coefficients, and melting points
-
additional information
synthesis of series of targetx02oriented competitive inhibitors of human soluble epoxide hydrolase. Molecular modeling reveals that the high inhibitory activity of this series of compounds is achieved by a unique mode of the binding to the active site of the enzyme, molecular docking study
-
additional information
synthesis and properties of symmetrical N,N-bis(R-adamantan-1-yl)ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors, structure is confirmed by 1H NMR and mass spectra and elemental analyses
-
additional information
-
sEH inhibitors are 1,3-disubstituted ureas, amides and carbamates that have IC50-values in the low nanomolar range. They only block the hydrolase activity of the enzyme without affecting the phosphatase domain
-
additional information
-
IC50 values with different substrates and structure-activity relationships of enzyme inhibitors, development of an in vitro inhibition assay using fluorogenic substrates
-
additional information
-
irreversible inhibition mechanism of chalcone oxide derivatives, quantitative structure-activity relationship, QSAR, overview
-
additional information
-
inhibitor synthesis, overview, inhibition mechanisms, overview
-
additional information
-
cyclohexandione is a poor inhibitor, no inhibition by amino-, guanido-, or activated serine-selective reagents
-
additional information
-
sterical differences play a role in inhibitory potency
-
additional information
-
quantitative structure-activity relationship, QSAR, and classification in a five-discriptor model of enzyme inhibition by 348 urea-like compounds, IC50 ranging from 60 nM to 0.5 mM, overview
-
additional information
-
no inhibition by Fe2+ and Fe3+ at 1 mM, metal chelators like 1,10-phenanthroline, 1,7-phenanthroline, EDTA, EGTA, and dipicolinic acid preserve enzyme activity in presence of metal ions
-
additional information
-
lipopolysaccharide has an effect on sEH expression and function, as evident from a significant down-regulation of Ephx2 mRNA
-
additional information
sEH inhibition is abolished by STAT3 siRNA
-
additional information
inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia. It downregulates the expression of proinflammatory mediators in the aortic tissue and in the blood
-
additional information
-
inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia. It downregulates the expression of proinflammatory mediators in the aortic tissue and in the blood
-
additional information
intervention with fish oil, but not with docosahexaenoic acid, results in significantly lower levels of hepatic sEH levels with time compared with high-oleic acid sunflower-seed oil, but the treatment does not influence atherosclerosis
-
additional information
the EET antagonist, 14,15-EEZE at 10 mM attenuates the increase in pulmonary artery pressure in the absence of the sEH inhibitor and completely prevents the increased constriction induced by 1-adamantyl-3-cyclohexylurea. Prolonged sEH inhibition results in significantly elevated serum levels of 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids/dihydroxyeicosatrienoic acids but fails to affect the ratio of the right/left ventricle and septum
-
additional information
treatment with sEH inhibitors reduces blood pressure in several animal models of hypertension
-
additional information
design and synthesis of small molecule enzyme inhibitors
-
additional information
administration of an sEH inhibitor significantly attenuates LPS-mediated induction of hepatic COX-2 expression and circulating PGE2 levels in mice
-
additional information
in vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors, identification of ligands structures by mass spectrometry and NMR spectroscopy, overview
-
additional information
inhibitory potency and metabolic stability of adamantyl ureas and diureas bearing substituents in bridgehead positions of adamantane and/or spacers between urea groups and adamantane group. Comparison of the effects of the inhibitors on human, rat, and murine enzymes, overview
-
additional information
-
inhibitory potency and metabolic stability of adamantyl ureas and diureas bearing substituents in bridgehead positions of adamantane and/or spacers between urea groups and adamantane group. Comparison of the effects of the inhibitors on human, rat, and murine enzymes, overview
-
additional information
differential effects of pharmarcological inhibition and genetic deletion of sEH on status epilepticus-induced cytokine expressions and ictogenesis, overview
-
additional information
-
differential effects of pharmarcological inhibition and genetic deletion of sEH on status epilepticus-induced cytokine expressions and ictogenesis, overview
-
additional information
-
enantioselectivity of urea inhibitors of soluble epoxide hydrolase. No inhibition by valpromide. Transition state of epoxide ring opening catalyzed by sEH, and binding mode of urea which mimic the transition state. The crystal structure of human soluble epoxide hydrolase, PDB ID 4OCZ, a complex with the 1-(1-isobutylpiperidin-4-yl)-3-(4-(trifluoromethyl)-phenyl)urea is used for docking simulation. The structure-activity relationship study of the enantiomers demonstrates that the absolute configuration of the 1-(alpha-alkyl-alpha-phenylmethyl)-3-(3-phenylpropyl)urea scaffold is crucial for the selectivity as well as activity
-
additional information
-
no inhibition by Mn2+, Ba2+, Mg2+, and Ca2+ at 1 mM, metal chelators like 1,10-phenanthroline, 1,7-phenanthroline, EDTA, EGTA, and dipicolinic acid preserve enzyme activity in presence of metal ions
-
additional information
-
pulmonary sEH protein expression and activity are impaired in monocrotaline-treated rats
-
additional information
SEH inhibition antagonizes neointimal formation in vivo in an endothelium-dependent manner
-
additional information
evaluation of spirocyclic secondary amine-derived trisubstituted ureas as highly potent, bioavailable and selective soluble epoxide hydrolase inhibitors, overview
-
additional information
design and synthesis of a series of potent nicotinamide inhibitors of soluble epoxides hydrolase, structure-guided optimization, overview
-
additional information
inhibitor screening, design, and synthesis, overview. Inhibition of sEH leads to an increase in epoxyeicosatrienoic acids resulting in the potentiation of their anti-inflammatory and vasodilatory effects
-
additional information
treatment with sEH inhibitors reduces blood pressure in several animal models of hypertension
-
additional information
synthesis and structure-based optimization of arylamides sEH inhibitors based on the solid-state costructure of N-(3,3-diphenyl-propyl)-nicotinamide, overview. Assessment of inhibitor stability in liver microsomes, overview
-
additional information
in vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors, identification of ligands structures by mass spectrometry and NMR spectroscopy, overview
-
additional information
inhibitory potency and metabolic stability of adamantyl ureas and diureas bearing substituents in bridgehead positions of adamantane and/or spacers between urea groups and adamantane group. Comparison of the effects of the inhibitors on human, rat, and murine enzymes, overview
-
additional information
design and synthesis of three substituted cyclopropyl urea derivatives as strong sEH inhibitors using X-ray co-crystal structure of sEH catalytic domain and 3-[4-[(1-[[(1S,2R)-2-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid, overview. cis-Configuration together with a phenyl group result in increased human and rat sEH inhibitory activity with minimal species difference
-
additional information
-
metal chelators like 1,10-phenanthroline, 1,7-phenanthroline, EDTA, EGTA, and dipicolinic acid preserve enzyme activity in presence of metal ions
-
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1.1
(1R,2R)-1,2-epoxy-1-phenyl-1-propane
Mus musculus
-
weak inhibition, IC50 is 1.1 mM
0.1
(1R,2R,4R,5S,6R,7S)-4-[(benzyloxy)methyl]-3,8-dioxatricyclo[5.1.0.02,4]octane-5,6-diyl diacetate
Homo sapiens
above, pH not specified in the publication, 37°C
2.4
(1S,2S)-1,2-epoxy-1-phenyl-1-propane
Mus musculus
-
weak inhibition, IC50 is 2.4 mM, preincubation of enzyme with inhibitor does not influence the inhibitory effect
0.03764
(1S,6S,9R)-1-(4-hydroxy-3-methoxyphenyl)-6-methoxy-9-methyl-4-(prop-2-en-1-yl)-7-oxabicyclo[4.2.1]non-4-ene-3,8-dione
Homo sapiens
pH not specified in the publication, 37°C
0.1
(2E)-4-[(2-methylpropyl)amino]-4-oxobut-2-enoic acid
Homo sapiens
pH not specified in the publication, 37°C
0.00783
(2E)-5-(2H-1,3-benzodioxol-5-yl)-N-(2-methylpropyl)pent-2-enamide
Homo sapiens
pH not specified in the publication, 37°C
0.00606
(2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-N-(2-methylpropyl)penta-2,4-dienamide
Homo sapiens
pH not specified in the publication, 37°C
0.09368
(2E,4E)-N-(2-methylpropyl)deca-2,4-dienamide
Homo sapiens
pH not specified in the publication, 37°C
0.00632
(2E,6E)-7-(2H-1,3-benzodioxol-5-yl)-N-(2-methylpropyl)hepta-2,6-dienamide
Homo sapiens
pH not specified in the publication, 37°C
0.069
(2R,3R)-1-acetoxy-2,3-epoxy-3-(4-nitrophenyl)propane
Mus musculus
-
IC50 is 0.069 mM
0.024
(2R,3R)-1-benzyloxy-2,3-epoxy-3-(4-nitrophenyl)propane
Mus musculus
-
IC50 is 0.024 mM
0.069
(2R,3R)-1-ethoxy-2,3-epoxy-3-(4-nitrophenyl)propane
Mus musculus
-
IC50 is 0.069 mM
1.2
(2R,3R)-2,3-epoxy-3-(4-nitrophenyl)glycidol
Mus musculus
-
IC50 is 1.2 mM, the S-enantiomer is a 750fold better inhibitor compared to the R-isomer
0.1
(2R,3R)-2-(2,6-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-1-benzopyran-4-one
Homo sapiens
above, pH not specified in the publication, 37°C
0.02616
(2R,3R,3aS)-2-(4-hydroperoxy-3-methoxyphenyl)-3a-methoxy-3-methyl-5-(prop-2-en-1-yl)-3,3a-dihydro-1-benzofuran-6(2H)-one
Homo sapiens
pH not specified in the publication, 37°C
0.1
(2R,3R,4S,5S)-2,5-bis(3,4-dimethoxyphenyl)-3,4-dimethyloxolane
Homo sapiens
above, pH not specified in the publication, 37°C
0.1
(2R,3S,4S,5S)-2,5-bis(3,4-dimethoxyphenyl)-3,4-dimethyloxolane
Homo sapiens
above, pH not specified in the publication, 37°C
0.07619
(2S)-5,7-dihydroxy-6-methoxy-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one
Homo sapiens
pH not specified in the publication, 37°C
0.05661
(2S,3R,3aR)-2-(4-hydroperoxy-3-methoxyphenyl)-3a-methoxy-3-methyl-5-(prop-2-en-1-yl)-3,3a-dihydro-1-benzofuran-6(2H)-one
Homo sapiens
pH not specified in the publication, 37°C
0.012
(2S,3S)-1-acetoxy-2,3-epoxy-3-(4-nitrophenyl)propane
Mus musculus
-
IC50 is 0.012 mM, preincubation of enzyme with inhibitor decreases the inhibitory effect
0.039
(2S,3S)-1-benzyloxy-2,3-epoxy-3-(4-nitrophenyl)propane
Mus musculus
-
IC50 is 0.039 mM
0.012
(2S,3S)-1-ethoxy-2,3-epoxy-3-(4-nitrophenyl)propane
Mus musculus
-
IC50 is 0.012 mM, preincubation of enzyme with inhibitor decreases the inhibitory effect
0.0016
(2S,3S)-2,3-epoxy-3-(4-nitrophenyl)glycidol
Mus musculus
-
IC50 is 0.0016 mM, the S-enantiomer is a 750fold better inhibitor compared to the R-isomer
0.00029 - 0.0021
(3-[4-(allyloxy)phenyl]oxiran-2-yl)(phenyl)methanone
0.00023 - 0.00028
(3-[4-(benzyloxy)phenyl]oxiran-2-yl)(phenyl)methanone
0.0000002 - 0.0000007
(3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(4-fluorobenzene-1-sulfonyl)amino]piperidine-1-carboxamide
0.0000008 - 0.0000014
(3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(methanesulfonyl)amino]piperidine-1-carboxamide
0.091
(4-bromo-3-cyclopropyl-1H-pyrazol-1-yl)acetic acid
Homo sapiens
37°C, pH 7.0
0.00022 - 0.0006
(4-bromophenyl)(3-phenyloxiran-2-yl)methanone
0.00014 - 0.00018
(4-bromophenyl)[3-(2-naphthyl)oxiran-2-yl]methanone
0.00039 - 0.0018
(4-fluorophenyl)(3-phenyloxiran-2-yl)methanone
0.00042 - 0.0014
(4-iodophenyl)(3-phenyloxiran-2-yl)methanone
0.0002 - 0.00032
(4-methoxyphenyl)(3-phenyloxiran-2-yl)methanone
0.00023 - 0.0017
(4-methylphenyl)(3-phenyloxiran-2-yl)methanone
0.00009 - 0.00015
(4-methylphenyl)[3-(2-naphthyl)oxiran-2-yl]methanol
0.0001 - 0.00019
(4-methylphenyl)[3-(2-naphthyl)oxiran-2-yl]methanone
0.00025 - 0.0015
(4-nitrophenyl)(3-phenyloxiran-2-yl)methanone
0.00012
(E)-4-[N-((2-trifluoromethyl)benzyl)benzamide]-alpha-ethylcinnamic acid
Homo sapiens
pH 7.0, 22°C
0.00007
(E)-N-methoxy-N-methyl 3-[4-(N-((2-trifluoromethyl)benzyl)-benzamide)]but-2-enamide
Homo sapiens
pH 7.0, 22°C
0.00029 - 0.0035
(E)-phenyl(3-phenyloxiran-2-yl)methanone oxime
0.035 - 0.042
(E)-[3-(2-naphthyl)oxiran-2-yl](phenyl)methanone oxime
0.000302
(R)-1-(1-cyclohexylethyl)-3-(3-phenylpropyl)urea
Oryctolagus cuniculus
-
pH 7.0, 30°C
-
0.00173
(R)-1-(1-phenylethyl)-3-(3-phenylpropyl)urea
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.0045
(R)-1-(1-phenylpropyl)-3-(3-phenylpropyl)urea
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.000022
(R)-1-(2,3-dihydro-1H-inden-1-yl)-3-(3-phenylpropyl)urea
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.00274
(R)-1-(2-hydroxy-1-phenylethyl)-3-(3-phenylpropyl)urea
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.000013
(R)-1-(3-phenylpropyl)-3-(1,2,3,4-tetrahydronaphthalen-1-yl)urea
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.000364
(R)-1-(naphthalen-1-yl)ethyl)-3-(3-phenylpropyl)urea
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.00151
(R)-2-phenyl-N-(3-phenylpropyl)pyrrolidine-1-carboxamide
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.00203
(R)-4-(3-(3-(1-phenylethyl)ureido)propyl)benzenesulfonamide
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.000014 - 0.000024
(R)-4-cyano-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-benzamide
0.000005
(R)-N-(2-(diphenylamino)ethyl)-3-(3-(1-hydroxyureido)but-1-yn-1-yl)benzamide
Homo sapiens
-
pH 7, 37°C
-
0.0000012
(R)-N-(3,3-bis(4-fluorophenyl)propyl)-3-(3-(1-hydroxyureido)but-1-yn-1-yl)benzamide
Homo sapiens
-
pH 7, 37°C
-
0.000023 - 0.000087
(R)-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-hydroxy-nicotinamide
0.000182
(S)-1-(1-cyclohexylethyl)-3-(3-phenylpropyl)urea
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.000044
(S)-1-(1-phenylethyl)-3-(3-phenylpropyl)urea
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.000036
(S)-1-(1-phenylpropyl)-3-(3-phenylpropyl)urea
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.000065
(S)-1-(2,3-dihydro-1H-inden-1-yl)-3-(3-phenylpropyl)urea
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.01999
(S)-1-(2-hydroxy-1-phenylethyl)-3-(3-phenylpropyl)urea
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.000013
(S)-1-(3-phenylpropyl)-3-(1,2,3,4-tetrahydronaphthalen-1-yl)urea
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.000043
(S)-1-(naphthalen-1-yl)ethyl)-3-(3-phenylpropyl)urea
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.000063
(S)-1-sec-butyl-3-(3-phenylpropyl)urea
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.000332
(S)-2-phenyl-N-(3-phenylpropyl)pyrrolidine-1-carboxamide
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.000022
(S)-4-(3-(3-(1-phenylethyl)ureido)propyl)benzenesulfonamide
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.000006 - 0.000008
(S)-4-cyano-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-benzamide
0.000006 - 0.000007
(S)-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-hydroxy-nicotinamide
0.0002
1,1'-(benzene-1,3-diyldicarbonyl)bis[N-(2,4-dichlorobenzyl)piperidine-4-carboxamide]
Homo sapiens
-
-
0.0000026
1,1'-(butane-1,4-diyl)bis(3-[1-(adamantan-1-yl) butane-2-yl]urea)
Homo sapiens
pH and temperature not specified in the publication
0.0000012
1,1'-(butane-1,4-diyl)bis(3-[1-(adamantan-1-yl)ethyl]urea)
Homo sapiens
pH and temperature not specified in the publication
0.0000028
1,1'-(hexane-1,6-diyl)bis(3-[1-(adamantan-1-yl) butane 2 yl]urea)
Homo sapiens
pH and temperature not specified in the publication
0.0000005
1,1'-(hexane-1,6-diyl)bis(3-[1-(adamantan-1-yl)ethyl]urea)
Homo sapiens
pH and temperature not specified in the publication
0.001442
1,1'-(octane-1,8-diyl)bis(3-[1-(adamantan-1-yl)butan 2 yl]urea)
Homo sapiens
pH and temperature not specified in the publication
0.0000005
1,1'-(octane-1,8-diyl)bis(3-[1-(adamantan-1-yl)ethyl]urea)
Homo sapiens
pH and temperature not specified in the publication
0.002475
1,1'-(phenylene 1,4)bis(3-[3,5-dimethyl(adamantan-1-yl)]urea)
Homo sapiens
pH and temperature not specified in the publication
0.01
1,1'-(phenylene-1,4)bis(3-[1-(adamantan-1-yl)butan-2-yl]urea)
Homo sapiens
pH and temperature not specified in the publication
0.000162
1,1'-(phenylene-1,4)bis(3-[1-(adamantan-1-yl)ethyl]urea)
Homo sapiens
pH and temperature not specified in the publication
0.00002
1,1'-(phenylene-1,4)bis[3-([adamantan-1-yl)urea]
Homo sapiens
pH and temperature not specified in the publication
0.0001792
1,2-(ethylene)bis[[(adamant-1-yl)methyl]urea]
Homo sapiens
-
pH and temperature not specified in the publication
0.000033
1,3-dicyclohexyl urea
Homo sapiens
-
pH 7.0, 23°C
0.0000195
1,4-(phenylene)bis[(adamant-2-yl)urea]
Homo sapiens
-
pH and temperature not specified in the publication
0.000161
1,4-(phenylene)bis[[(adamant-1-yl)ethyl-1]urea]
Homo sapiens
-
pH and temperature not specified in the publication
0.0007796
1,4-(phenylene)bis[[(adamant-1-yl)methyl]urea]
Homo sapiens
-
pH and temperature not specified in the publication
0.0000263
1,4-(tetramethylene)bis[(adamant-1-yl)methyl]urea
Homo sapiens
-
pH and temperature not specified in the publication
0.0000072
1,4-(tetramethylene)bis[(adamant-1-yl)urea]
Homo sapiens
-
pH and temperature not specified in the publication
0.0000012
1,4-(tetramethylene)bis[[(adamant-1-yl)ethyl-1]urea]
Homo sapiens
-
pH and temperature not specified in the publication
0.0000023
1,4-(tetramethylene)bis[[(adamant-1-yl)sec-butyl-1]urea]
Homo sapiens
-
pH and temperature not specified in the publication
0.0000104
1,4-(tetramthylene)bis[(adamant-2-yl)urea]
Homo sapiens
-
pH and temperature not specified in the publication
0.0000004
1,6-(hexamethylene)bis[[(adamant-1-yl)methyl]urea]
Homo sapiens
-
pH and temperature not specified in the publication
0.000997
1,8-(octamethylene)bis[(adamant-1-yl)urea]
Homo sapiens
-
pH and temperature not specified in the publication
0.0000005
1,8-(octamethylene)bis[(adamant-1-ylethyl)urea]
Homo sapiens
-
pH and temperature not specified in the publication
0.0000026
1,8-(octamethylene)bis[(adamant-2-yl)urea]
Homo sapiens
-
pH and temperature not specified in the publication
0.0000005
1,8-(octamethylene)bis[[(adamant-1-yl)ethyl-1]urea]
Homo sapiens
-
pH and temperature not specified in the publication
0.0000073
1,8-(octamethylene)bis[[(adamant-1-yl)methyl]urea]
Homo sapiens
-
pH and temperature not specified in the publication
0.00144
1,8-(octamethylene)bis[[(adamant-1-yl)sec-butyl-1]urea]
Homo sapiens
-
pH and temperature not specified in the publication
0.000028 - 0.000035
1-(1-acetylpiperidin-4-yl)-3-cycloheptylurea
0.000015
1-(1-acetylpiperidin-4-yl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
Homo sapiens
-
0.000012
1-(1-acetylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea
Homo sapiens
-
0.0074
1-(1-cyclopropylethyl)-3-phenylurea
Homo sapiens
in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C
0.0000029
1-(1-methanesulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)-urea
Homo sapiens
-
0.000003 - 0.000005
1-(1-methylsulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)-urea
0.0000016
1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)-urea
Homo sapiens
-
0.000178
1-(2-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylic acid
Homo sapiens
-
in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C
0.000206 - 0.000258
1-(2-hydroxyphenyl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
0.000007 - 0.00001
1-(3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)-3-phenylpropan-1-one
0.000304
1-(3-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylic acid
Homo sapiens
-
in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C
0.000029
1-(3-(5-(hydroxyureido)methyl-2-methoxyphenoxy)propyl)-3-[4-(trifluoromethoxy)phenyl]urea
Homo sapiens
recombinant enzyme, pH 7.0, 22°C
0.000613 - 0.000813
1-(3-hydroxypropyl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
0.000073
1-(4-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylic acid
Homo sapiens
-
in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C
0.0000012
1-(4-(N1-methyl-N2-methyl-N2-(methyloxy)oxalamido)-benzyl)-3-adamantylurea
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.000019
1-(4-(N2-(tetrahydro-2H-pyran-2-yloxy)oxalamido)benzyl)-3-adamantylurea
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.000005
1-(4-(N2-methyl-N2-(methyloxy)oxalamido)benzyl)-3-adamantylurea
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.0000066
1-(4-(N2-methyloxyoxalamido)benzyl)-3-adamantylurea
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.000019
1-(4-(N2-tert-butyloxyoxalamido)benzyl)-3-adamantylurea
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.0000036
1-(4-acetylphenyl)-N-(5-chloro-1,3-benzoxazol-2-yl)piperidine-4-carboxamide
Homo sapiens
pH 7.4, 22°C
0.0000036
1-(4-acetylphenyl)-N-(5-methyl-1,3-benzoxazol-2-yl)piperidine-4-carboxamide
Homo sapiens
pH 7.4, 22°C
0.000013
1-(4-chlorophenyl)-3-(3,4-dichlorophenyl)urea
Homo sapiens
-
0.00012 - 0.000128
1-(5-hydroxypentyl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
0.0000032
1-(adamantan-1-yl)-3-(1-propionylpiperidin-4-yl)urea
Homo sapiens
pH 7.4, 37°C
0.0000014
1-adamantan-1-yl-3-(5-(2-[2-(2,2,2-trifluoroethoxy)ethoxy]-ethoxy)pentyl)urea
Homo sapiens
-
30°C, pH 7.0
0.0000017
1-adamantan-1-yl-3-(5-(2-[2-(4-ethylphenoxy)ethoxy]-ethoxy)pentyl)urea
Homo sapiens
-
30°C, pH 7.0
0.0000041
1-adamantan-1-yl-3-(5-butoxypentyl)urea
Homo sapiens
-
30°C, pH 7.0
0.0000056
1-adamantan-1-yl-3-(5-hexoxypropyl)urea
Homo sapiens
-
30°C, pH 7.0
0.0000044
1-adamantan-1-yl-3-(5-pentoxybutyl)urea
Homo sapiens
-
30°C, pH 7.0
0.0000037
1-adamantan-1-yl-3-(5-propyloxyhexyl)urea
Homo sapiens
-
30°C, pH 7.0
0.000002 - 0.000086
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
0.0000023
1-adamantan-1-yl-3-(5-[4-propyloxy]butyl)-urea
Homo sapiens
-
30°C, pH 7.0
0.0000025
1-adamantan-1-yl-3-(5-[4-propyloxy]propyl)-urea
Homo sapiens
-
30°C, pH 7.0
0.000003 - 0.000014
1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea
0.0000147
1-adamantanyl-3-(5-(2-(2-ethoxyethoxy)ethoxy)pentyl)urea
Homo sapiens
-
0.00326
1-benzyl-3-(3-phenylpropyl)urea
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.000016
1-benzyl-3-tricyclo[3.3.1.13,7]dec-1-ylurea
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.000019 - 0.0000852
1-cyclohexyl-3-dodecyl urea
0.0098
1-cyclohexyl-3-ethyl urea
Homo sapiens
-
pH 7.0, 23°C
0.000029
1-cyclohexyl-3-hexyl urea
Homo sapiens
-
pH 7.0, 23°C
0.0000039
1-cyclohexyl-3-[3-(3-morpholin-4-ylpropoxy)phenyl]urea
Homo sapiens
-
-
0.00065
1-sec-butyl-3-(3-phenylpropyl)urea
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.000012 - 0.000097
1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl)urea
0.0000291
1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)-urea
Rattus norvegicus
-
in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C
0.0000037
1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)urea
Homo sapiens
pH 7.4, 37°C
0.001
1-[(2,4-dichlorobenzyl)carbamoyl]piperidine-4-carboxylic acid
Rattus norvegicus
-
0.000041
1-[(2,4-dimethylphenyl)sulfonyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000011
1-[(2,4-dimethylphenyl)sulfonyl]-N-(2-fluorophenyl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000012
1-[(2,4-dimethylphenyl)sulfonyl]-N-(2-hydroxyphenyl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00002
1-[(2,4-dimethylphenyl)sulfonyl]-N-(2-methylphenyl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000018
1-[(2,4-dimethylphenyl)sulfonyl]-N-(2-methylpropyl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00029
1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-fluorophenyl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000004
1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-hydroxyphenyl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000025
1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-methoxyphenyl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000012
1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-nitrophenyl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00002
1-[(2,4-dimethylphenyl)sulfonyl]-N-(4-phenoxyphenyl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.03
1-[(2,4-dimethylphenyl)sulfonyl]-N-(6-methoxy-1,3-benzodioxol-5-yl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000023
1-[(2,4-dimethylphenyl)sulfonyl]-N-(isoquinolin-5-yl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000083
1-[(2,4-dimethylphenyl)sulfonyl]-N-(naphthalen-2-yl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000023
1-[(2,4-dimethylphenyl)sulfonyl]-N-(quinolin-3-yl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000013
1-[(2,4-dimethylphenyl)sulfonyl]-N-(quinolin-6-yl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000006
1-[(2,4-dimethylphenyl)sulfonyl]-N-(quinolin-8-yl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000017
1-[(2,4-dimethylphenyl)sulfonyl]-N-(tricyclo[3.3.1.13,7]dec-1-yl)piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000069
1-[(2,4-dimethylphenyl)sulfonyl]-N-phenylpiperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0069
1-[(2,4-dimethylphenyl)sulfonyl]-N-[(1R,2S)-2-phenylcyclopropyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00064
1-[(2,4-dimethylphenyl)sulfonyl]-N-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00025
1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(morpholin-4-yl)phenyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00002
1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(piperidin-1-yl)phenyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000067
1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(propan-2-yl)phenyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000023
1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(trifluoromethoxy)phenyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00003
1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-(trifluoromethyl)phenyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000016
1-[(2,4-dimethylphenyl)sulfonyl]-N-[4-[(trifluoromethyl)sulfonyl]phenyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000911
1-[(2-bromophenyl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide
Homo sapiens
-
-
0.0000521
1-[(4-chloro-2,5-dimethylphenyl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide
Homo sapiens
-
-
0.000164
1-[(4-tert-butylphenyl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide
Homo sapiens
-
-
0.0002
1-[(5-chlorothiophen-2-yl)sulfonyl]-N-(2,4-dichlorobenzyl)piperidine-4-carboxamide
Homo sapiens
-
-
0.0000133
1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
Rattus norvegicus
-
in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C
0.0000018
1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
Rattus norvegicus
-
in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C
0.000003
1-[1-(methylsulfonyl)piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
Homo sapiens
-
0.00002
1-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-3-[4-(trifluoromethoxy)phenyl]urea
Rattus norvegicus
-
in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C
0.00000125
1-[1-[(2S)-2-methylbutanoyl]piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea
Rattus norvegicus
-
IC50 below 0.00000125 mM, in sodium phosphate buffer (0.1 M, pH 7.4), at 30°C
0.000126
1-[2-methyl-6-(methylamino)pyridin-4-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000005
1-[2-methyl-6-(methylamino)pyrimidin-4-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000747
1-[2-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylic acid
Homo sapiens
-
in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C
0.000022
1-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]thiourea
Homo sapiens
-
-
0.0000008
1-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]urea
Homo sapiens
-
-
0.0000082
1-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[4-(trifluoromethoxy)phenyl]urea
Homo sapiens
-
-
0.0000012
1-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[4-(trifluoromethyl)phenyl]urea
Homo sapiens
-
-
0.0023 - 0.0187
1-[3-(4-nitrophenyl)oxiran-2-yl]ethanol
0.163 - 0.269
1-[3-(4-nitrophenyl)oxiran-2-yl]ethanone
1.2
1-[3-(trifluoromethyl)pyridin-2-yl]piperazine
Homo sapiens
37°C, pH 7.0
0.000943
1-[3-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)benzyl]-1H-pyrrole-2-carboxylic acid
Homo sapiens
-
in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C
0.000032
1-[3-methyl-5-(methylamino)phenyl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.001923
1-[3-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylic acid
Homo sapiens
-
in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C
0.00002
1-[4,6-bis(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000001
1-[4-(dimethylamino)-6-methyl-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00004
1-[4-(methylamino)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000001
1-[4-(methylamino)-6-phenyl-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.052
1-[4-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-4-ol
Homo sapiens
37°C, pH 7.0
0.000258
1-[4-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)benzyl]-1H-pyrrole-2-carboxylic acid
Homo sapiens
-
in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C
0.000001
1-[4-cyclohexyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000004
1-[4-ethyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000001
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethoxy)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000003
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0004 - 0.00063
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[3-(trifluoromethoxy)benzyl]piperidine-4-carboxamide
0.00001
1-[4-methyl-6-(methylamino)pyridin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00016
1-[4-methyl-6-(methylamino)pyrimidin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000001
1-[4-methyl-6-(morpholin-4-yl)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000001
1-[4-methyl-6-(propan-2-ylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000001
1-[4-[(2-methoxyethyl)amino]-6-methyl-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000252
1-[4-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylic acid
Homo sapiens
-
in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C
0.00008
1-[4-[[2-(dimethylamino)ethyl](methyl)amino]-6-(methylamino)-1,3,5-triazin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000008 - 0.000014
1-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
0.00004
1-[6-methyl-2-(methylamino)pyrimidin-4-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.001585
1-[6-methyl-4-(methylamino)pyridin-2-yl]-N-[2-(trifluoromethyl)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0000397
1-[[1-((adamant-1-yl)methylcarbamoyl)piperidin-4-yl]methyl]-3-[(adamant-1-yl)methyl]urea
Homo sapiens
-
pH and temperature not specified in the publication
0.003
1-[[4-(trifluoromethoxy)phenyl]carbamoyl]piperidine-4-carboxylic acid
Rattus norvegicus
-
0.028
10-(sulfooxy)octadecanoic acid
Homo sapiens
-
IC50 is 0.028 mM
0.0000017
12-(3-adamantan-1-yl-ureido) 2-chlorobenzyl dodecanoate
Homo sapiens
-
-
0.0000012
12-(3-adamantan-1-yl-ureido) 2-methylpropyl dodecanoate
Homo sapiens
-
-
0.0000007
12-(3-adamantan-1-yl-ureido) butan-2-yl dodecanoate
Homo sapiens
-
-
0.0000008
12-(3-adamantan-1-yl-ureido) butyl dodecanoate
Homo sapiens
-
-
0.0000016
12-(3-adamantan-1-yl-ureido) ethyl dodecanoate
Homo sapiens
-
-
0.0000021
12-(3-adamantan-1-yl-ureido) N-(methylsulfonyl)dodecanylamide
Homo sapiens
-
-
0.0000019
12-(3-adamantan-1-yl-ureido) N-(phenylsulfonyl)dodecanylamide
Homo sapiens
-
-
0.000001
12-(3-adamantan-1-yl-ureido) prop-2-en-1-yl dodecanoate
Homo sapiens
-
-
0.0000018
12-(3-adamantan-1-yl-ureido) prop-2-yn-1-yl dodecanoate
Homo sapiens
-
-
0.0000011
12-(3-adamantan-1-yl-ureido) propan-2-yl dodecanoate
Homo sapiens
-
-
0.000001
12-(3-adamantan-1-yl-ureido) propyl dodecanoate
Homo sapiens
-
-
0.0000013
12-(3-adamantan-1-yl-ureido) tert-butyl dodecanoate
Homo sapiens
-
-
0.0000032
12-(3-adamantan-1-yl-ureido)-dodecanoic acid
Homo sapiens
-
0.0000008
12-(3-adamantan-1-yl-ureido)-dodecanoic acid butylester
Homo sapiens
-
0.000003 - 0.000107
12-(3-adamantan-1-yl-ureido)dodecanoic acid
0.000007
12-(3-adamantan-1-yl-ureido)dodecanoic acid butyl ester
Rattus norvegicus
-
0.000003 - 0.000011
12-(3-adamantan-1-ylureido)dodecanoic acid
0.0000008 - 0.000005
12-(3-adamantan-1-ylureido)dodecanoic acid butyl ester
0.0000046 - 0.000059
12-(3-adamantane-1-yl-ureido)-dodecanoic acid
0.1
12-sulfonoxy-cis-9-octadecenoic acid
Homo sapiens
-
IC50 is above 0.1 mM
0.016
12-sulfonoxy-trans-9-octadecenoic acid
Homo sapiens
-
IC50 is 0.016 mM
0.0000022 - 0.000003
12-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]dodecanoic acid
0.000002 - 0.000059
12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid
0.0029 - 0.023
2,3-epoxy-1,3-diphenyl-propan-1-one
0.0006 - 0.013
2,3-epoxy-1-(4-bromophenyl)-3-phenyl-propan-1-one
0.0014 - 0.03
2,3-epoxy-1-(4-ethylphenyl)-3-phenyl-propan-1-one
0.0012 - 0.022
2,3-epoxy-1-(4-fluorophenyl)-3-phenyl-propan-1-one
0.00021 - 0.0054
2,3-epoxy-1-(4-methoxyphenyl)-3-phenyl-propan-1-one
0.0015 - 0.019
2,3-epoxy-1-(4-nitroxyphenyl)-3-phenyl-propan-1-one
0.00137 - 0.0025
2,3-epoxy-1-(4-phenylphenyl)-3-phenyl-propan-1-one
0.00012 - 0.0022
2,3-epoxy-3-(4-bromophenyl)-1-phenyl-propan-1-one
0.00016 - 0.0056
2,3-epoxy-3-(4-ethylphenyl)-1-phenyl-propan-1-one
0.00048 - 0.0047
2,3-epoxy-3-(4-fluorophenyl)-1-phenyl-propan-1-one
0.00019 - 0.0028
2,3-epoxy-3-(4-methoxyphenyl)-1-phenyl-propan-1-one
0.00015 - 0.0017
2,3-epoxy-3-(4-n-butylphenyl)-1-phenyl-propan-1-one
0.00018 - 0.011
2,3-epoxy-3-(4-nitrophenyl)-1-phenyl-propan-1-one
0.00014
2,3-epoxy-3-(4-phenylphenyl)-1-phenyl-propan-1-one
Mus musculus
-
IC50: 0.00014 mM
0.127
2-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazole
Homo sapiens
in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C
0.000001 - 0.000004
2-(2,4-dichlorophenyl)-1-[6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl]ethanone
0.1
2-(2,6-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
Homo sapiens
above, pH not specified in the publication, 37°C
0.009
2-(2-fluorophenyl)-N-[(5-methylthiophen-2-yl)methyl]ethan-1-amine
Homo sapiens
37°C, pH 7.0
0.07 - 0.073
2-(2-naphthyl)-3-(phenylsulfinyl)oxirane
0.0043
2-(3,4-dihydroxy-5-methoxyphenyl)-5,7-dihydroxy-1-benzopyran-1-ium-3-yl beta-D-glucopyranoside
Homo sapiens
pH 7.0, 37°C
0.0102
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-1-benzopyran-1-ium
Homo sapiens
pH 7.0, 37°C
0.0146
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-1-benzopyran-1-ium-3-yl beta-D-glucopyranoside
Homo sapiens
pH 7.0, 37°C
0.00011
2-(hydroxymethyl)-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
Rattus norvegicus
-
0.0000283
2-(tricyclo[3.3.1.13,7]dec-1-yl)-N-[1-(trifluoroacetyl)piperidin-4-yl]acetamide
Homo sapiens
-
0.00051
2-([[2-(adamantan-1-yl)ethyl]amino]methyl)phenol
0.00031 - 0.0023
2-cyclohexa-1,5-dien-1-yl-3-(phenylsulfinyl)oxirane
0.034 - 0.103
2-cyclohexa-1,5-dien-1-yl-3-[methoxy(phenyl)methyl]oxirane
0.000028
2-cyclohexyl-N-[3-(3-morpholin-4-ylpropoxy)phenyl]acetamide
Homo sapiens
-
-
0.015
2-cyclopentyl-N-(1,3-thiazol-2-yl)acetamide
Homo sapiens
in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C
0.0012
2-ethyl 3-[4-(N-(4-fluoro(2-trifluoromethyl)benzyl)-benzamide)]propionic acid
Homo sapiens
pH 7.0, 22°C
0.0009
2-ethyl-3-[3-(N-((2-trifluoromethyl)benzyl)benzamide)]-propionic acid
Homo sapiens
pH 7.0, 22°C
0.0016
2-ethyl-3-[4-(N-((2-trifluoromethyl)benzyl)benzamide)]-propionic acid
Homo sapiens
pH 7.0, 22°C
0.0015
2-ethyl-3-[4-(N-((4-chloro)benzyl)benzamide)]propionic acid
Homo sapiens
pH 7.0, 22°C
0.012
2-ethyl-3-[4-(N-((4-phenoxy)benzyl)benzamide)]propionic acid
Homo sapiens
pH 7.0, 22°C
0.014
2-ethyl-3-[4-(N-((4-trifluoromethoxy)benzyl)benzamide)]-propionic acid
Homo sapiens
pH 7.0, 22°C
0.0072
2-ethyl-3-[4-(N-((4-trifluoromethyl)benzyl)benzamide)]-propionic acid
Homo sapiens
pH 7.0, 22°C
0.00033
2-ethyl-3-[4-(N-(4-methoxy(2-trifluoromethyl)benzyl)-benzamide)]propionic acid
Homo sapiens
pH 7.0, 22°C
0.002
2-hydroxy-N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]acetamide
Homo sapiens
-
IC50 above 0.02 mM
0.000023
2-hydroxy-N-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
Homo sapiens
-
-
0.00053
2-hydroxy-N-[3-(3-morpholin-4-ylpropoxy)phenyl]-4-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]butanamide
Homo sapiens
-
-
0.02082
2-methoxy-4-[7-methoxy-3-methyl-5-[(1E)-prop-1-en-1-yl]-1-benzofuran-2-yl]phenol
Homo sapiens
pH not specified in the publication, 37°C
0.008
2-methyl 3-[4-(N-((2-Trifluoromethyl)benzyl)benzamide)]-propionic acid
Homo sapiens
pH 7.0, 22°C
0.000029
2-methyl-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
Rattus norvegicus
-
0.717
2-methylglycidyl 4-nitrobenzoate
Mus musculus
-
IC50 for the S-enantiomer is 0.717 mM, the R-enantiomer shows 25% inhibition at 0.2 mM
0.00028 - 0.0014
2-naphthyl(3-phenyloxiran-2-yl)methanone
0.00107
2-oxo-2,3-dihydro-1,3-benzoxazol-4-yl 4-methylbenzoate
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.0025
2-phenyl-3-[4-(N-((2-trifluoromethyl)benzyl)benzamide)]-propionic acid
Homo sapiens
pH 7.0, 22°C
0.005
2-propyl-3-[4-(N-((2-trifluoromethyl)benzyl)benzamide)]-propionic acid
Homo sapiens
pH 7.0, 22°C
0.0001199
2-[2-(adamantan-1-yl)ethyl]-N-(3,5-dimethyladamantan-1-yl)hydrazine-1-carboxamide
Homo sapiens
pH 7.4, 37°C
0.0000285
2-[2-(adamantan-1-yl)ethyl]-N-[(adamantan-1-yl)methyl]hydrazine-1-carboxamide
Homo sapiens
pH 7.4, 37°C
0.0000796
2-[3-(adamantan-1-yl)propyl]-N-(3,5-dimethyladamantan-1-yl)hydrazine-1-carboxamide
Homo sapiens
pH 7.4, 37°C
0.0055
2-[4-(N-((2-trifluoromethyl)benzyl )benzamide)]-cyclopropanecarboxylic acid
Homo sapiens
pH 7.0, 22°C
0.00048 - 0.00134
2-[methoxy(phenyl)methyl]-3-(2-naphthyl)oxirane
0.012
3,3-dimethylglycidyl 4-nitrobenzoate
Mus musculus
-
IC50 for the S-enantiomer is 0.012 mM, 23% inhibition at 5 mM of the R-enantiomer
0.000004 - 0.00001
3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl[4-(trifluoromethyl)phenyl]methanone
0.195
3-(2-amino-1,3-thiazol-4-yl)-5-methyl-1-(tetrahydrofuran-2-ylmethyl)-1H-pyrrol-2-ol
Homo sapiens
in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C
0.00009
3-(3-(1-hydroxyureido)but-1-yn-1-yl)-N-(2-(trifluoromethyl)-benzyl)benzamide
Homo sapiens
-
pH 7, 37°C
-
0.00007
3-(3-(1-hydroxyureido)but-1-yn-1-yl)-N-(3-phenyl-3-(4-(trifluoromethoxy)phenyl)propyl)benzamide
Homo sapiens
-
pH 7, 37°C
-
0.000004
3-(3-(1-hydroxyureido)but-1-yn-1-yl)-N-(4-methoxy-2-(trifluoromethyl)benzyl)-benzamide
Homo sapiens
-
pH 7, 37°C
-
0.0003
3-(3-(1-hydroxyureido)hex-1-yn-1-yl)-N-(2-(trifluoromethyl)-benzyl)benzamide
Homo sapiens
-
pH 7, 37°C
-
0.000005 - 0.000026
3-(3-amino-3-oxopropyl)-N-(4-chlorophenyl)-3-phenylpiperidine-1-carboxamide
0.000007
3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propylamine
Rattus norvegicus
-
0.003
3-(hydroxymethyl)-N-(1-phenylethyl)piperidine-1-carboxamide
Rattus norvegicus
-
0.0015
3-(hydroxymethyl)-N-(2-methylbenzyl)piperidine-1-carboxamide
Rattus norvegicus
-
0.003
3-(hydroxymethyl)-N-(3-methylbenzyl)piperidine-1-carboxamide
Rattus norvegicus
-
0.0029
3-(hydroxymethyl)-N-(4-methylbenzyl)piperidine-1-carboxamide
Rattus norvegicus
-
0.000019
3-(hydroxymethyl)-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
Rattus norvegicus
-
0.000001
3-([cis-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]cyclohexyl]oxy)benzoic acid
Homo sapiens
-
0.0000004
3-([[(adamantan-1-yl)methyl]carbamoyl]amino)adamantan-1-yl trifluoroacetate
Homo sapiens
pH 7.4, 37°C
0.000001 - 0.000003
3-methyl-3-phenyl-N-(4-(pyridin-3-yl)benzyl)piperidine-1-carboxamide
0.000249 - 0.00055
3-methyl-3-phenyl-N-(pyridin-4-yl)piperidine-1-carboxamide
0.000006 - 0.000007
3-methyl-3-phenyl-N-[3-(pyridin-3-yl)propyl]piperidine-1-carboxamide
0.000001 - 0.000004
3-methyl-3-phenyl-N-[3-[(1S,2S)-2-phenylcyclopropyl]benzyl]piperidine-1-carboxamide
0.000005 - 0.000019
3-methyl-3-phenyl-N-[3-[2-(quinoxalin-6-yl)ethyl]benzyl]piperidine-1-carboxamide
0.000008 - 0.000011
3-methyl-3-phenyl-N-[[2'-(trifluoromethyl)biphenyl-4-yl]methyl]piperidine-1-carboxamide
0.000012
3-methyl-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
Rattus norvegicus
-
0.000019 - 0.00029
3-[1-[(4-chlorophenyl)carbamoyl]-3-(pyridin-2-yl)piperidin-3-yl]propanoic acid
0.000028 - 0.000331
3-[1-[(4-chlorophenyl)carbamoyl]-3-(pyridin-3-yl)piperidin-3-yl]propanoic acid
0.00003 - 0.000467
3-[1-[(4-chlorophenyl)carbamoyl]-3-(pyridin-4-yl)piperidin-3-yl]propanoic acid
0.000005 - 0.000076
3-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]propanoic acid
0.000012 - 0.000176
3-[1-[(4-chlorophenyl)carbamoyl]-3-[3-(trifluoromethyl)phenyl]piperidin-3-yl]propanoic acid
0.000005 - 0.00012
3-[1-[(4-chlorophenyl)carbamoyl]-3-[4-(trifluoromethyl)phenyl]piperidin-3-yl]propanoic acid
0.000008 - 0.000413
3-[3-(biphenyl-4-yl)-1-[(4-chlorophenyl)carbamoyl]piperidin-3-yl]propanoic acid
0.15
3-[4-(benzyloxy)phenyl]propan-1-ol
Homo sapiens
37°C, pH 7.0
0.009
3-[4-(N-((2-trifluoromethyl)benzyl)benzamide)]propionic acid
Homo sapiens
pH 7.0, 22°C
0.0001
3-[4-[(1-[[(1R,3S)-2,2-dimethyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
0.0000191 - 0.0000556
3-[4-[(1-[[(1S,2R)-2-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
0.0000117 - 0.000012
3-[4-[(1-[[(1S,2R,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
0.0000021 - 0.0000032
3-[4-[(1-[[(1s,2R,3S)-2,3-bis(4-fluorophenyl)cyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
0.0000023 - 0.0000039
3-[4-[(1-[[(1s,2R,3S)-2,3-diphenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
0.0000757 - 0.0001
3-[4-[(1-[[(1S,2S,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
0.000008 - 0.000031
4'-hydroxy-N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide
0.001
4'-[([2-(trifluoromethyl)phenyl]methyl)carbamoyl][1,1'-biphenyl]-3-carboxylic acid
Homo sapiens
pH 7.0, 22°C
0.00017
4'-[([2-(trifluoromethyl)phenyl]methyl)carbamoyl][1,1'-biphenyl]-4-carboxylic acid
Homo sapiens
pH 7.0, 22°C
0.000018 - 0.000045
4,4-diphenyl-N-(pyridin-3-yl)-butyramide
0.0000753
4,5-dimethoxy-2-nitrophenyl 4-[(2,4-dichlorobenzyl)carbamoyl]piperidine-1-carboxylate
Homo sapiens
-
-
0.000002
4-((4-(3-(adamantan-1-yl)ureido)trans-cyclohexyl)oxy)benzoic acid
Homo sapiens
pH 7.4, 37°C
0.000054
4-(1,2,4-oxadiazol-3-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
Homo sapiens
-
0.000235
4-(1,3,4-oxadiazol-2-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
Homo sapiens
-
0.0000075
4-(1,3-benzoxazol-2-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
Homo sapiens
-
0.00012
4-(1-methyl-1H-1,2,3-triazol-4-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
Homo sapiens
-
0.000011
4-(1H-pyrrol-1-yl)-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
Rattus norvegicus
-
0.00043
4-(2,3-dihydro-1H-1,2,3-triazol-1-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
Homo sapiens
-
0.0000039
4-(2-cyanophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide
Rattus norvegicus
-
0.0026
4-(3-(1-hydroxyureido)but-1-yn-1-yl)-N-(2-(trifluoromethyl)-benzyl)benzamide
Homo sapiens
-
pH 7, 37°C
-
0.5
4-(3-benzoyloxiran-2-yl)benzoic acid
0.0000049
4-(3-cyanophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide
Rattus norvegicus
-
0.0011
4-(3-hydroxy-4-methyl-1,2-oxazol-5-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
Homo sapiens
-
0.000028
4-(3-methyl-1,2,4-oxadiazol-5-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
Homo sapiens
-
0.0000059
4-(4-chlorophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide
Rattus norvegicus
-
0.0000042
4-(4-cyanophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide
Rattus norvegicus
-
0.0084
4-(4-methyl-4H-1,2,4-triazol-3-yl)-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
Homo sapiens
-
0.0000041
4-(5-phenyl-3-[3-[3-(3-trifluoromethyl-phenyl)-ureido]-propyl]-pyrazol-1-yl)-benzenesulfonamide
Homo sapiens
pH 7.0, 30°C
0.0000005
4-(5-phenyl-3-[3-[3-(4-trifluoromethoxy-phenyl)-ureido]-propyl]-pyrazol-1-yl)-benzenesulfonamide
Homo sapiens
pH 7.0, 30°C
0.0000009
4-(5-phenyl-3-[3-[3-(4-trifluoromethyl-phenyl)-ureido]-propyl]-pyrazol-1-yl)-benzenesulfonamide
Homo sapiens
pH 7.0, 30°C
0.000005
4-(5-[1-[(2-phenylcyclopropyl)carbamoyl]piperidin-4-yl]-1,2,4-oxadiazol-3-yl)benzoic acid
Homo sapiens
-
0.000046
4-(hydroxymethyl)-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
Rattus norvegicus
-
0.000008
4-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.0000053
4-([1-[(2,4-dichlorobenzyl)carbamoyl]piperidin-4-yl]oxy)benzoic acid
Rattus norvegicus
-
0.00008 - 0.00016
4-([3-(2-naphthyl)oxiran-2-yl]carbonyl)benzoic acid
0.103 - 0.113
4-([3-(4-fluorophenyl)oxiran-2-yl]carbonyl)benzoic acid
0.000002
4-([trans-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]cyclohexyl]oxy)benzoic acid
Homo sapiens
-
0.061
4-benzyl-3,4-dihydroquinoxalin-2(1H)-one
Homo sapiens
in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C
0.000015
4-benzyl-N-(2,4-dichlorobenzyl)-4-hydroxypiperidine-1-carboxamide
Rattus norvegicus
-
0.00021 - 0.0048
4-bromo-4'-methoxychalcone
0.000005 - 0.000007
4-cyano-N-[3,3-bis-(4-fluorophenyl)-propyl]-benzamide
0.026
4-fluorochalcone oxide
Mus musculus
-
IC50 is 0.026 mM
0.1
4-hydroxy-3,5-dimethoxybenzaldehyde
Homo sapiens
above, pH not specified in the publication, 37°C
0.1
4-hydroxy-3-methoxybenzaldehyde
Homo sapiens
above, pH not specified in the publication, 37°C
0.000018
4-methyl-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
Rattus norvegicus
-
0.1
4-nitrophenyl sulfate
Homo sapiens
-
IC50 is above 0.1 mM
0.000003 - 0.000039
4-oxo-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
0.000001 - 0.000007
4-oxo-N-(2-phenylcyclopropyl)-6-(pyridin-4-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
0.000008 - 0.000021
4-oxo-N-(3-phenylcyclopentyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
0.00002 - 0.000028
4-oxo-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
0.000003 - 0.000009
4-oxo-N-[(1S,2R)-2-phenylcyclopropyl]-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
0.073 - 0.144
4-[(3-phenyloxiran-2-yl)carbonyl]benzoic acid
0.0000005
4-[(4-[[(3-methyladamantan-1-yl)carbamoyl]amino]cyclohexyl)oxy]benzoic acid
Homo sapiens
pH 7.4, 37°C
0.000002
4-[(4-[[(adamantan-1-yl)carbamoyl]amino]cyclohexyl)oxy]benzoic acid
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.000017
4-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.000012 - 0.000176
4-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]butanoic acid
0.5
4-[3-(4-fluorobenzoyl)oxiran-2-yl]benzoic acid
0.00001
4-[3-(isoquinolin-1-yl)-1,2,4-oxadiazol-5-yl]-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
Homo sapiens
-
0.000008
4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]-N-(1,2,3,4-tetrahydronaphthalen-2-yl)piperidine-1-carboxamide
Homo sapiens
-
0.000036
4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)piperidine-1-carboxamide
Homo sapiens
-
0.000007
4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]-N-[4-(trifluoromethyl)phenyl]piperidine-1-carboxamide
Homo sapiens
-
0.000004
4-[3-[4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-N-(2-phenylcyclopropyl)piperidine-1-carboxamide
Homo sapiens
-
0.0000016
4-[[(1r,4r)-4-([[(adamantan-1-yl)methyl]carbamoyl]amino)cyclohexyl]oxy]benzoic acid
Homo sapiens
pH 7.4, 37°C
0.0000017 - 0.0000345
4-[[(1r,4r)-4-[[(3,5,7-trimethyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
0.0000008
4-[[(1r,4r)-4-[[(3,5-dimethyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
Homo sapiens
pH 7.4, 37°C
0.0000014
4-[[(1r,4r)-4-[[(3-chloroadamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
Homo sapiens
pH 7.4, 37°C
0.0000018
4-[[(1r,4r)-4-[[(3-ethyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
Homo sapiens
pH 7.4, 37°C
0.0000005
4-[[(1r,4r)-4-[[(3-methyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
Homo sapiens
pH 7.4, 37°C
0.0000045
4-[[(2R,5R)-5-[[(2-oxoadamantan-1-yl)carbamoyl]amino]piperidin-2-yl]oxy]benzoic acid
Homo sapiens
pH 7.4, 37°C
0.000001
4-[[cis-4-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)cyclohexyl]oxy]benzoic acid
Homo sapiens
-
0.1
5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
Homo sapiens
above, pH not specified in the publication, 37°C
0.1
5,6,7-trihydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one
Homo sapiens
above, pH not specified in the publication, 37°C
0.03389
5,6-dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl D-threo-hexopyranosiduronic acid
Homo sapiens
pH not specified in the publication, 37°C
0.1
5,7,8-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
Homo sapiens
above, pH not specified in the publication, 37°C
0.03391 - 0.08008
5,7-dihydroxy-2-(2-hydroxy-6-methoxyphenyl)-4H-1-benzopyran-4-one
0.1
5,7-dihydroxy-2-(2-hydroxyphenyl)-4H-1-benzopyran-4-one
Homo sapiens
above, pH not specified in the publication, 37°C
0.1
5,7-dihydroxy-2-(2-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
Homo sapiens
above, pH not specified in the publication, 37°C
0.0112
5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-1-benzopyran-1-ium-3-yl beta-D-galactopyranoside
Homo sapiens
pH 7.0, 37°C
0.0253
5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-1-benzopyran-1-ium-3-yl beta-D-glucopyranoside
Homo sapiens
pH 7.0, 37°C
0.1
5,7-dihydroxy-2-phenyl-4H-1-benzopyran-4-one
Homo sapiens
above, pH not specified in the publication, 37°C
0.04482
5,7-dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one
Homo sapiens
pH not specified in the publication, 37°C
0.1
5,7-dihydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one
Homo sapiens
above, pH not specified in the publication, 37°C
0.07
5-(4-bromobenzyl)-1,3-thiazol-2-amine
Homo sapiens
in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C
0.00004
5-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.01
5-benzyl-N-phenyl-1,3,4-oxadiazol-2-amine
Homo sapiens
above
0.1
5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxy-4H-1-benzopyran-4-one
Homo sapiens
above, pH not specified in the publication, 37°C
0.1
5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
Homo sapiens
pH not specified in the publication, 37°C
0.0063
5-methyl-N-(2-phenylethyl)-4,5-dihydro-1,3-thiazol-2-amine
Homo sapiens
in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C
0.0047
5-phenyl-N-[4-(trifluoromethyl)benzyl]-1,2-oxazol-3-amine
Homo sapiens
-
0.01
5-phenyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazol-3-amine
Homo sapiens
above
0.000005 - 0.00012
5-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]pentanoic acid
0.000008 - 0.000049
6'-(methylsulfonyl)-N-(2-phenylcyclopropyl)-1H,4'H-spiro[azepane-4,3'-chromene]-1-carboxamide
0.000004 - 0.000021
6-(1-methyl-1H-pyrazol-5-yl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
0.00007
6-(1H-indol-5-yl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.000091
6-(2-fluorophenyl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.00007
6-(3-methylpyridin-2-yl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.000019
6-(isoquinolin-5-yl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.000003 - 0.000029
6-(methylsulfonyl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
0.000023
6-(pyridin-3-yl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.000058
6-(pyridin-4-yl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.049
6-(trifluoromethyl)-1,3-benzothiazol-2-amine
Homo sapiens
in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C
0.000018
6-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.029
6-amino-1-methyl-5-(piperidin-1-yl)pyrimidine-2,4(1H,3H)-dione
Homo sapiens
in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C
0.00043 - 0.00052
6-amino-N-(2,4-dichlorobenzyl)pyridine-3-carboxamide
0.0000085 - 0.0000091
6-amino-N-(3,3-diphenylpropyl)pyridine-3-carboxamide
0.000003 - 0.000018
6-fluoro-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
0.01
6-phenyl-N-[3-(trifluoromethyl)benzyl]pyrimidin-4-amine
Homo sapiens
above
0.000003 - 0.000013
6-[(1-methyl-1H-pyrazol-5-yl)amino]-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
0.0000006
6-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]naphthalene-2-carboxylic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.00047
6-[3-(trifluoromethyl)phenyl]-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.000008
7-(1H-indol-5-yl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.000004
7-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
0.01
7-(trifluoromethyl)-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
Homo sapiens
above
0.000019
7-(trifluoromethyl)-N-[5-(trifluoromethyl)pyridin-2-yl][1,2]oxazolo[5,4-c]pyridin-3-amine
Homo sapiens
-
0.000074
7-(trifluoromethyl)-N-[6-(trifluoromethyl)pyridin-3-yl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.000004
7-[2-(trifluoromethyl)phenyl]-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.00001
7-[3-(trifluoromethyl)phenyl]-N-[5-(trifluoromethyl)pyridin-2-yl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.09
9-hydroxy-10-(sulfooxy)octadecanoic acid
Homo sapiens
-
IC50 is 0.09 mM
0.073
alpha-hydroxyfarnesyl phosphonic acid
Homo sapiens
-
IC50 is 0.073 mM
0.1
alpha-sulfostearic acid
Homo sapiens
-
IC50 is above 0.1 mM
0.0000016
AR9276
Mus musculus
-
0.000001
butyl 12-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]dodecanoate
Homo sapiens
recombinant enzyme expressed in Escherichia coli or Sf9 cells
0.055
Chalcone oxide
Mus musculus
-
IC50 is 0.055 mM
0.0000009
cis-1-adamantan-1-yl-3-(4-benzyloxycyclohexyl)urea
Homo sapiens
pH 7.4, 30°C
0.0000015
cis-1-adamantan-1-yl-3-[4-(2,6-dichlorobenzyloxy)cyclohexyl]-urea
Homo sapiens
pH 7.4, 30°C
0.0000011
cis-1-adamantan-1-yl-3-[4-(2,6-difluorobenzyloxy)cyclohexyl]-urea
Homo sapiens
pH 7.4, 30°C
0.0000013
cis-1-adamantan-1-yl-3-[4-(4-bromophenoxy)cyclohexyl]urea
Homo sapiens
pH 7.4, 30°C
0.000001
cis-1-adamantan-1-yl-3-[4-(4-fluorophenoxy)cyclohexyl]-urea
Homo sapiens
pH 7.4, 30°C
0.00000055
cis-1-adamantan-1-yl-3-[4-(4-methoxyphenoxy)cyclohexyl]-urea
Homo sapiens
pH 7.4, 30°C
0.00000072
cis-1-adamantan-1-yl-3-[4-(4-nitrophenoxy)cyclohexyl]urea
Homo sapiens
pH 7.4, 30°C
0.0000019
cis-3-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
Homo sapiens
pH 7.4, 30°C
0.0000006
cis-4-(4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy)-benzoic acid
Homo sapiens
pH 7.4, 30°C
0.0000009 - 0.000007
cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
0.1
D-galactose 6-sulfate
Homo sapiens
-
IC50 is above 0.1 mM
0.1
dibenzyl phosphonate
Homo sapiens
-
IC50 is above 0.1 mM
0.000003
dicyclohexylurea
Rattus norvegicus
-
0.1
diethyl 2,2,2-trifluoro-1-hydroxyethyl phosphonate
Homo sapiens
-
IC50 is above 0.1 mM
0.1
diethyl 4-methylbenzyl phosphonate
Homo sapiens
-
IC50 is above 0.1 mM
0.1
diethyl allyl phosphonate
Homo sapiens
-
IC50 is above 0.1 mM
0.1
diethyl benzoylphosphonate
Homo sapiens
-
IC50 is above 0.1 mM
0.1
diethyl cyclopropyl methylphosphonate
Homo sapiens
-
IC50 is above 0.1 mM
0.1
diethyl ethylthiomethyl phosphonate
Homo sapiens
-
IC50 is above 0.1 mM
0.1
diethyl trans-cinnamyl phosphonate
Homo sapiens
-
IC50 is above 0.1 mM
0.1
diethyl vinylphosphonate
Homo sapiens
-
IC50 is above 0.1 mM
0.1
dimethyl 2-oxoheptyl phosphonate
Homo sapiens
-
IC50 is above 0.1 mM
0.092
dioctyl phenyl phosphonate
Homo sapiens
-
IC50 is 0.092 mM
0.04
dodecyl phosphonic acid
Homo sapiens
-
IC50 is 0.040 mM
0.1
Estrone 3-sulfate
Homo sapiens
-
IC50 is above 0.1 mM
0.00004
ethyl (E)-3-[N-((2-trifluoromethyl)benzyl)benzamide]-alpha-ethylcinnamate
Homo sapiens
pH 7.0, 22°C
0.0004
ethyl (E)-3-[N-((2-trifluoromethyl)benzyl)benzamide]-alpha-ethylcinnamic acid
Homo sapiens
pH 7.0, 22°C
0.000063
ethyl (E)-4-[N-((2-(trifluoromethyl)-benzyl)benzamide]-alpha-ethylcinnamate
Homo sapiens
pH 7.0, 22°C
0.000043
ethyl 1-(2-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylate
Homo sapiens
-
in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C
0.000046
ethyl 1-(3-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylate
Homo sapiens
-
in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C
0.000087
ethyl 1-(4-((3-((3s,5s,7s)-adamantan-1-yl)ureido)methyl)benzyl)-1H-pyrrole-2-carboxylate
Homo sapiens
-
in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C
0.002009
ethyl 1-[2-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)benzyl]-1H-pyrrole-2-carboxylate
Homo sapiens
-
in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C
0.000039
ethyl 1-[2-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylate
Homo sapiens
-
in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C
0.000027
ethyl 1-[3-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylate
Homo sapiens
-
in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C
0.000611
ethyl 1-[4-([[4-(trifluoromethoxy)phenyl]carbamoyl]amino)benzyl]-1H-pyrrole-2-carboxylate
Homo sapiens
-
in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C
0.000023
ethyl 1-[4-[(cyclohexylcarbamoyl)amino]benzyl]-1H-pyrrole-2-carboxylate
Homo sapiens
-
in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C
0.000027
ethyl 2-ethyl 3-[3-(N-((2-trifluoromethyl)benzyl)benzamide)]-propanoate
Homo sapiens
pH 7.0, 22°C
0.000044
ethyl 2-ethyl 3-[4-(N-((2-trifluoromethyl)benzyl)benzamide)]propanoate
Homo sapiens
pH 7.0, 22°C
0.0017
ethyl 2-ethyl 3-[4-(N-((4-chloro)benzyl)benzamide)]-propanoate
Homo sapiens
pH 7.0, 22°C
0.0022
ethyl 2-ethyl 3-[4-(N-((4-fluoro)benzyl)benzamide)]-propanoate
Homo sapiens
pH 7.0, 22°C
0.00062
ethyl 2-ethyl 3-[4-(N-((4-methoxy)benzyl)benzamide)]-propanoate
Homo sapiens
pH 7.0, 22°C
0.0009
ethyl 2-ethyl 3-[4-(N-((4-trifluoromethoxy)benzyl)-benzamide)]propanoate
Homo sapiens
pH 7.0, 22°C
0.00057
ethyl 2-ethyl 3-[4-(N-((4-trifluoromethyl)benzyl)benzamide)]-propanoate
Homo sapiens
pH 7.0, 22°C
0.00012
ethyl 2-ethyl 3-[4-(N-(4-fluoro(2-trifluoromethyl)benzyl)-benzamide)]propanoate
Homo sapiens
pH 7.0, 22°C
0.00003
ethyl 2-ethyl 3-[4-(N-(4-methoxy(2-trifluoromethyl)benzyl)-benzamide)]propanoate
Homo sapiens
pH 7.0, 22°C
0.004
ethyl 2-ethyl-3-[4-(N-((2-bromo)benzyl)benzamide)]-propanoate
Homo sapiens
pH 7.0, 22°C
0.0038
ethyl 2-ethyl-3-[4-(N-((2-chloro)benzyl)benzamide)]-propanoate
Homo sapiens
pH 7.0, 22°C
0.0009
ethyl 2-ethyl-3-[4-(N-((2-methyl)benzyl)benzamide)]-propanoate
Homo sapiens
pH 7.0, 22°C
0.00003
ethyl 2-ethyl-3-[4-(N-((2-trifluoromethoxy)benzyl)-benzamide)]prop
Homo sapiens
pH 7.0, 22°C
0.0085
ethyl 2-ethyl-3-[4-(N-benzylbenzamide)]propanoate
Homo sapiens
pH 7.0, 22°C
0.00025
ethyl 2-methyl 3-[4-(N-((2-trifluoromethyl)benzyl)benzamide)]-propanoate
Homo sapiens
pH 7.0, 22°C
0.00012
ethyl 2-phenyl 3-[4-(N-((2-trifluoromethyl)benzyl)benzamide)]-propanoate
Homo sapiens
pH 7.0, 22°C
0.00017
ethyl 2-propyl 3-[4-(N-((2-trifluoromethyl)benzyl)benzamide)]-propanoate
Homo sapiens
pH 7.0, 22°C
0.00011
ethyl 3-[4-(N-((2-trifluoromethyl)benzyl)benzamide)]-propanoate
Homo sapiens
pH 7.0, 22°C
0.14 - 0.514
glycidyl 4-nitrobenzoate
0.000014
IK950
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.1
L-ascorbic acid 2-sulfate
Homo sapiens
-
IC50 is above 0.1 mM
0.0000017
methyl 2-([4-[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]piperidin-1-yl]carbonyl)benzoate
Homo sapiens
-
0.000003
methyl 2-hydroxy-4-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]benzoate
Homo sapiens
-
0.0000018
methyl 2-[(4-[[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]methyl]piperidin-1-yl)carbonyl]benzoate
Homo sapiens
-
0.0000011
methyl 3-([4-[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]piperidin-1-yl]carbonyl)benzoate
Homo sapiens
-
0.0000041
methyl 3-[(4-[[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]methyl]piperidin-1-yl)carbonyl]benzoate
Homo sapiens
-
0.000001 - 0.000003
methyl 3-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]propanoate
0.0000021
methyl 4-((1,2,3,4-tetrahydronaphthalene-2-carboxamido)methyl)benzoic acid
Homo sapiens
-
pH 7.0, 30°C
0.0000011
methyl 4-([4-[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]piperidin-1-yl]carbonyl)benzoate
Homo sapiens
-
0.0000018
methyl 4-([[(6-hydroxynaphthalen-2-yl)carbonyl]amino]methyl)benzoate
Homo sapiens
-
pH 7.0, 30°C
0.0000024
methyl 4-([[(6-methoxynaphthalen-2-yl)carbonyl]amino]methyl)benzoate
Homo sapiens
-
pH 7.0, 30°C
0.0000015
methyl 4-[(4-[[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]methyl]piperidin-1-yl)carbonyl]benzoate
Homo sapiens
-
0.0000085
methyl 4-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]benzoate
Homo sapiens
-
pH and temperature not specified in the publication
0.0000091
methyl 4-[[(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)amino]methyl]benzoate
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.0000034
methyl 5-oxo-5-(4-[[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]methyl]piperidin-1-yl)pentanoate
Homo sapiens
-
0.0000027
methyl 5-oxo-5-[4-[(tricyclo[3.3.1.13,7]dec-2-ylcarbamoyl)amino]piperidin-1-yl]pentanoate
Homo sapiens
-
0.00011
methyl 6-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]naphthalene-2-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0000336
N'-(2-chlorophenyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carbohydrazide
Homo sapiens
-
-
0.000064
N'-[2-(3-chlorophenyl)ethyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carbohydrazide
Homo sapiens
-
-
0.01
N,5-dibenzyl-1,3,4-oxadiazol-2-amine
Homo sapiens
above
0.0168
N,N'-(butane-1,4-diyl)bis[4-(adamantan-2-yl)piperazine-1-carboxamide]
Homo sapiens
pH 7.4, 37°C
0.0004086
N,N'-1,2-phenylenebis[N'-(3-chloroadamantan-1-yl)urea]
Homo sapiens
pH 7.4, 37°C
0.001364
N,N'-1,2-phenylenebis[N'-[(adamantan-1-yl)methyl]urea]
Homo sapiens
pH 7.4, 37°C
0.000779
N,N'-1,4-phenylenebis[N'-[(adamantan-1-yl)methyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000016 - 0.0000662
N,N'-bis(3,5,7-trimethyladamantan-1-yl)urea
0.0000011
N,N'-bis(3,5-dimethyladamantan-1-yl)urea
Homo sapiens
pH 7.4, 37°C
0.0000006 - 0.0000021
N,N'-bis(3-chloroadamantan-1-yl)urea
0.000004
N,N'-bis(3-ethyladamantan-1-yl)urea
Homo sapiens
pH 7.4, 37°C
0.0000031 - 0.0000055
N,N'-bis(3-methyladamantan-1-yl)urea
0.0000054
N,N'-bis[(adamantan-1-yl)methyl]urea
Homo sapiens
pH 7.4, 37°C
0.0000234
N,N'-butane-1,4-diylbis[N'-(3,5-dimethyladamantan-1-yl)urea]
Homo sapiens
pH 7.4, 37°C
0.0000013
N,N'-butane-1,4-diylbis[N'-(3-chloroadamantan-1-yl)urea]
Homo sapiens
pH 7.4, 37°C
0.0000011
N,N'-butane-1,4-diylbis[N'-(3-ethyladamantan-1-yl)urea]
Homo sapiens
pH 7.4, 37°C
0.0000007
N,N'-butane-1,4-diylbis[N'-[(3,5-dimethyladamantan-1-yl)methyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000009
N,N'-butane-1,4-diylbis[N'-[(adamantan-1-yl)methyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000019
N,N'-butane-1,4-diylbis[N'-[1-(adamantan-1-yl)-2-methylpropan-2-yl]urea]
Homo sapiens
pH 7.4, 37°C
0.000605
N,N'-butane-1,4-diylbis[N'-[2-(adamantan-1-yl)-2-phenylethyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000034
N,N'-butane-1,4-diylbis[N'-[2-(adamantan-1-yl)ethyl]urea]
Homo sapiens
pH 7.4, 37°C
0.003299
N,N'-butane-1,4-diylbis[N'-[2-(adamantan-1-yl)pentyl]urea]
Homo sapiens
pH 7.4, 37°C
0.001792
N,N'-butane-1,4-diylbis[N'-[4-(adamantan-1-yl)phenyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000009
N,N'-decane-1,10-diylbis[N'-(3-chloroadamantan-1-yl)urea]
Homo sapiens
pH 7.4, 37°C
0.05
N,N'-dicyclohexylurea
Strongylocentrotus purpuratus
more than the value, recombinant SPEH1
0.0001445
N,N'-ethane-1,2-diylbis[N'-(3-chloroadamantan-1-yl)urea]
Homo sapiens
pH 7.4, 37°C
0.0001792
N,N'-ethane-1,2-diylbis[N'-[(adamantan-1-yl)methyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000014
N,N'-heptane-1,7-diylbis[N'-(3-chloroadamantan-1-yl)urea]
Homo sapiens
pH 7.4, 37°C
0.0000004
N,N'-heptane-1,7-diylbis[N'-[(adamantan-1-yl)methyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000094
N,N'-hexane-1,6-diylbis(N'-[3-[(adamantan-1-yl)oxy]propyl]urea)
Homo sapiens
pH 7.4, 37°C
0.0000016
N,N'-hexane-1,6-diylbis[N'-(3-chloroadamantan-1-yl)urea]
Homo sapiens
pH 7.4, 37°C
0.0000085
N,N'-hexane-1,6-diylbis[N'-(3-ethyladamantan-1-yl)urea]
Homo sapiens
pH 7.4, 37°C
0.000001
N,N'-hexane-1,6-diylbis[N'-[(3,5-dimethyladamantan-1-yl)methyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000005
N,N'-hexane-1,6-diylbis[N'-[1-(adamantan-1-yl)ethyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000043
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)-2-methylpropyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000915
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)-2-phenylethyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000028
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)butyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000008
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)ethyl]urea]
Homo sapiens
pH 7.4, 37°C
0.035
N,N'-hexane-1,6-diylbis[N'-[2-(adamantan-1-yl)pentyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0005293
N,N'-hexane-1,6-diylbis[N'-[4-(adamantan-1-yl)phenyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000027
N,N'-octane-1,8-diylbis(N'-[3-[(adamantan-1-yl)oxy]propyl]urea)
Homo sapiens
pH 7.4, 37°C
0.0000037
N,N'-octane-1,8-diylbis[N'-(3,5-dimethyladamantan-1-yl)urea]
Homo sapiens
pH 7.4, 37°C
0.0000012
N,N'-octane-1,8-diylbis[N'-(3-chloroadamantan-1-yl)urea]
Homo sapiens
pH 7.4, 37°C
0.0000025
N,N'-octane-1,8-diylbis[N'-[(3,5-dimethyladamantan-1-yl)methyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000006 - 0.0000007
N,N'-octane-1,8-diylbis[N'-[(adamantan-1-yl)methyl]urea]
0.0000067
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)-2-methylpropyl]urea]
Homo sapiens
pH 7.4, 37°C
0.000205
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)-2-phenylethyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000015
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)ethyl]urea]
Homo sapiens
pH 7.4, 37°C
0.1
N,N'-octane-1,8-diylbis[N'-[2-(adamantan-1-yl)pentyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0002591
N,N'-octane-1,8-diylbis[N'-[4-(adamantan-1-yl)phenyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000018
N,N'-pentane-1,5-diylbis[N'-(3-chloroadamantan-1-yl)urea]
Homo sapiens
pH 7.4, 37°C
0.0000012
N,N'-pentane-1,5-diylbis[N'-(3-ethyladamantan-1-yl)urea]
Homo sapiens
pH 7.4, 37°C
0.0000009
N,N'-pentane-1,5-diylbis[N'-[(adamantan-1-yl)methyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000017
N,N'-propane-1,3-diylbis[N'-(3-chloroadamantan-1-yl)urea]
Homo sapiens
pH 7.4, 37°C
0.0000017
N,N'-propane-1,3-diylbis[N'-(3-ethyladamantan-1-yl)urea]
Homo sapiens
pH 7.4, 37°C
0.0000009
N,N'-propane-1,3-diylbis[N'-[(adamantan-1-yl)methyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000012
N,N'-undecane-1,11-diylbis[N'-[(adamantan-1-yl)methyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000019
N,N'-[1,4-phenylenebis(methylene)]bis[N'-(3,5-dimethyladamantan-1-yl)urea]
Homo sapiens
pH 7.4, 37°C
0.0000201
N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.000059 - 0.000307
N-(1,2-benzoxazol-3-yl)-3-methyl-3-phenylpiperidine-1-carboxamide
0.0000052
N-(1,3-benzodioxol-5-yl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000274
N-(1-acetylpiperidin-4-yl)-2-(tricyclo[3.3.1.13,7]dec-1-yl)acetamide
Homo sapiens
-
0.000007
N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl) urea
Homo sapiens
-
0.000006 - 0.000009
N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
0.58
N-(1-tert-butoxyethenyl)-1,2,3,4-tetrahydroquinolin-3-amine
Homo sapiens
37°C, pH 7.0
0.000011
N-(1-tert-butoxypiperidin-4-yl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.0000011
N-(1-trifluoroacetylpiperidin-4-yl)-N'-(adamant-1-yl) urea
Homo sapiens
-
0.003
N-(2,2-diphenyl-ethyl)-nicotinamide
0.000005 - 0.000035
N-(2,3-dihydro-1H-inden-1-yl)-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
0.00013
N-(2,3-dihydro-1H-inden-1-yl)-4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
Homo sapiens
-
0.0000491
N-(2,3-dihydro-1H-inden-2-yl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.000128
N-(2,4-dichloro-6-methylbenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.000006 - 0.000016
N-(2,4-dichlorobenzyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
0.0000445
N-(2,4-dichlorobenzyl)-1-[(2,4,6-tri-tert-butylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.00002
N-(2,4-dichlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.0000469
N-(2,4-dichlorobenzyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.0000876
N-(2,4-dichlorobenzyl)-1-[(2-fluorophenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.00015
N-(2,4-dichlorobenzyl)-1-[(4-fluoro-2-nitrophenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.0000239
N-(2,4-dichlorobenzyl)-1-[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.000041
N-(2,4-dichlorobenzyl)-3-(hydroxymethyl)piperidine-1-carboxamide
Rattus norvegicus
-
0.000001 - 0.000003
N-(2,4-dichlorobenzyl)-3-methyl-3-phenylpiperidine-1-carboxamide
0.0000061
N-(2,4-dichlorobenzyl)-4-(4-fluorophenoxy)piperidine-1-carboxamide
Rattus norvegicus
-
0.000006
N-(2,4-dichlorobenzyl)-4-(pyridin-2-yl)piperazine-1-carboxamide
Rattus norvegicus
-
0.000012
N-(2,4-dichlorobenzyl)-4-(pyridin-2-ylmethyl)piperidine-1-carboxamide
Rattus norvegicus
-
0.000015
N-(2,4-dichlorobenzyl)-4-(pyrimidin-2-yloxy)piperidine-1-carboxamide
Rattus norvegicus
-
0.000027
N-(2,4-dichlorobenzyl)-4-hydroxy-4-phenylpiperidine-1-carboxamide
Rattus norvegicus
-
0.0000043
N-(2,4-dichlorobenzyl)-4-phenoxypiperidine-1-carboxamide
Rattus norvegicus
-
0.000039
N-(2,4-dichlorobenzyl)-4-[(4-fluorophenyl)sulfonyl]piperidine-1-carboxamide
Rattus norvegicus
-
0.0000049
N-(2,4-dichlorobenzyl)-4-[2-(methylsulfonyl)phenoxy]piperidine-1-carboxamide
Rattus norvegicus
-
0.0000046
N-(2,4-dichlorobenzyl)-4-[3-(methylsulfonyl)phenoxy]piperidine-1-carboxamide
Rattus norvegicus
-
0.0000042
N-(2,4-dichlorobenzyl)-4-[4-(methylcarbamoyl)phenoxy]piperidine-1-carboxamide
Rattus norvegicus
-
0.0000052
N-(2,4-dichlorobenzyl)-4-[4-(methylsulfamoyl)phenoxy]piperidine-1-carboxamide
Rattus norvegicus
-
0.0000056
N-(2,4-dichlorobenzyl)-4-[4-(methylsulfonyl)phenoxy]piperidine-1-carboxamide
Rattus norvegicus
-
0.000012
N-(2,4-dichlorobenzyl)-4-[4-(trifluoromethoxy)phenoxy]piperidine-1-carboxamide
Rattus norvegicus
-
0.0000056
N-(2,4-dichlorobenzyl)-4-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
Rattus norvegicus
-
0.000017
N-(2,4-dichlorobenzyl)-4-[[(4-fluorophenyl)sulfonyl]amino]piperidine-1-carboxamide
Rattus norvegicus
-
0.0000066 - 0.0000073
N-(2,4-dichlorobenzyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
0.00033 - 0.0004
N-(2,4-dichlorobenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
0.0005 - 0.0015
N-(2,4-dichlorobenzyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
0.0000322
N-(2,4-difluorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.0000591
N-(2,5-dichlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.0000006
N-(2-bromophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000008 - 0.000014
N-(2-chloro-4-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.0000541
N-(2-chloro-4-fluorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.0000127
N-(2-chloro-6-fluorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.0000274
N-(2-chlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.000021 - 0.000022
N-(2-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.0000087
N-(2-chlorophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00008
N-(2-cyanobenzyl)-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000001 - 0.0016
N-(2-methoxybenzyl)-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
0.0002
N-(2-methylbenzyl)-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0000372
N-(2-methylcyclohexyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.0000004
N-(2-oxoadamantan-1-yl)-N'-1,3,5-triazatricyclo[3.3.1.13,7]decan-7-ylurea
Homo sapiens
pH 7.4, 37°C
0.000005 - 0.000021
N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide
0.000004 - 0.000011
N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
0.0011
N-(2-phenylcyclopropyl)-4-(1H-1,2,4-triazol-1-yl)piperidine-1-carboxamide
Homo sapiens
-
0.00048
N-(2-phenylcyclopropyl)-4-(1H-pyrazol-1-yl)piperidine-1-carboxamide
Homo sapiens
-
0.000013
N-(2-phenylcyclopropyl)-4-[3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
Homo sapiens
-
0.000009
N-(2-phenylcyclopropyl)-4-[3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
Homo sapiens
-
0.000007
N-(2-phenylcyclopropyl)-4-[3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
Homo sapiens
-
0.000014
N-(2-phenylcyclopropyl)-4-[3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
Homo sapiens
-
0.000033
N-(2-phenylcyclopropyl)-4-[3-(pyrimidin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
Homo sapiens
-
0.000007
N-(2-phenylcyclopropyl)-4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
Homo sapiens
-
0.000009
N-(2-phenylcyclopropyl)-4-[3-[2-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
Homo sapiens
-
0.0000433
N-(2-phenylethyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.000031 - 0.00015
N-(3,3-diphenyl-propyl)-2-pyridine-3-ylacetamide
0.0000048 - 0.0000079
N-(3,3-diphenyl-propyl)-isonicotinamide
0.0000048 - 0.000007
N-(3,3-diphenyl-propyl)-nicotinamide
0.0000026 - 0.000004
N-(3,3-diphenylpropyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
0.000035
N-(3,3-diphenylpropyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.0000054 - 0.0000078
N-(3,3-diphenylpropyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
0.0000081 - 0.00001
N-(3,3-diphenylpropyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
0.000009 - 0.000018
N-(3,3-diphenylpropyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
0.000032
N-(3,4-dichlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.0002
N-(3,4-dichlorobenzyl)-3-(hydroxymethyl)piperidine-1-carboxamide
Rattus norvegicus
-
0.000055
N-(3,4-dichlorophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000065 - 0.000436
N-(3,5,7-trimethyladamantan-1-yl)-4-([[(3,5,7-trimethyladamantan-1-yl)carbamoyl]amino]methyl)piperidine-1-carboxamide
0.000025
N-(3,5-dichlorophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000018 - 0.0000052
N-(3,5-dimethyladamantan-1-yl)-N'-(1-propanoylpiperidin-4-yl)urea
0.0000971 - 0.011376
N-(3,5-dimethyladamantan-1-yl)-N'-(3,5,7-trimethyladamantan-1-yl)urea
0.002894
N-(3,5-dimethyladamantan-1-yl)-N'-1,3,5-triazatricyclo[3.3.1.13,7]decan-7-ylurea
Homo sapiens
pH 7.4, 37°C
0.0000015
N-(3,5-dimethyladamantan-1-yl)-N'-[(3-ethyladamantan-1-yl)methyl]urea
Homo sapiens
pH 7.4, 37°C
0.002475
N-(3,5-dimethyladamantan-1-yl)-N'-[4-([[(3,5-dimethyladamantan-1-yl)carbamoyl]amino]methyl)phenyl]urea
Homo sapiens
pH 7.4, 37°C
0.000002
N-(3-(4-chlorophenyl)-3-phenylpropyl)-3-(3-(1-hydroxyureido)-but-1-yn-1-yl)benzamide
Homo sapiens
-
pH 7, 37°C
-
0.0000038 - 0.0002686
N-(3-ethyladamantan-1-yl)-N'-(1-propanoylpiperidin-4-yl)urea
0.0000399
N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-2-(tricyclo[3.3.1.13,7]dec-1-yl)acetamide
Homo sapiens
-
0.0000251
N-(3-methylbutyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.00007 - 0.0007
N-(3-phenyl-propyl)-nicotinamide
0.000026 - 0.00012
N-(4,4-diphenyl-butyl)-nicotinamide
0.000204
N-(4-(N1-methyl-N2-methyl-N2-(methyloxy)oxalamido)-benzyl)adamantanecarboxamide
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.001
N-(4-(N2-(tetrahydro-2H-pyran-2-yloxy)oxalamido)benzyl)adamantanecarboxamide
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.00019
N-(4-(N2-methyl-N2-(methyloxy)oxalamido)benzyl)adamantanecarboxamide
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.00018
N-(4-(N2-methyloxyoxalamido)benzyl)adamantanecarboxamide
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.000408
N-(4-(N2-tert-butyloxyoxalamido)benzyl)adamantanecarboxamide
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.000007 - 0.000012
N-(4-bromo-2-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.000045
N-(4-bromophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00005
N-(4-chlorobenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.000007 - 0.000077
N-(4-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.0022
N-(4-chlorophenyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000003 - 0.000016
N-(4-chlorophenyl)-3-(2-cyanoethyl)-3-phenylpiperidine-1-carboxamide
0.000001 - 0.000015
N-(4-chlorophenyl)-3-(2-hydroxyethyl)-3-phenylpiperidine-1-carboxamide
0.0000013 - 0.00001
N-(4-chlorophenyl)-3-(3-hydroxypropyl)-3-phenylpiperidine-1-carboxamide
0.000001 - 0.000005
N-(4-chlorophenyl)-3-methyl-3-phenylpiperidine-1-carboxamide
0.000005 - 0.000059
N-(4-chlorophenyl)-3-phenyl-3-[2-(1H-tetrazol-5-yl)ethyl]piperidine-1-carboxamide
0.000012 - 0.000119
N-(4-chlorophenyl)-3-[2-(dimethylamino)ethyl]-3-phenylpiperidine-1-carboxamide
0.0000014 - 0.000034
N-(4-chlorophenyl)-3-[2-oxo-2-(1H-tetrazol-5-ylamino)ethyl]-3-phenylpiperidine-1-carboxamide
0.000003 - 0.000031
N-(4-chlorophenyl)-3-[3-(diethylamino)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide
0.000005 - 0.000032
N-(4-chlorophenyl)-3-[3-(methylamino)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide
0.000008 - 0.0001
N-(4-chlorophenyl)-3-[3-(morpholin-4-yl)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide
0.000026 - 0.000029
N-(4-chlorophenyl)-3-[3-oxo-3-(1H-tetrazol-5-ylamino)propyl]-3-phenylpiperidine-1-carboxamide
0.0000396
N-(4-methylcyclohexyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.00014 - 0.0017
N-(4-[(3-phenyloxiran-2-yl)carbonyl]phenyl)acetamide
0.0000072
N-(4-[[(adamantan-1-yl)carbamoyl]amino]butyl)-N'-(3,5-dimethyladamantan-1-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000032
N-(5-chloro-1,3-benzoxazol-2-yl)-2-cyclopentylacetamide
Homo sapiens
pH 7.4, 22°C
0.0000003
N-(6-[[(adamantan-1-yl)carbamoyl]amino]hexyl)-N'-(3,5-dimethyladamantan-1-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.000997
N-(8-[[(adamantan-1-yl)carbamoyl]amino]octyl)-N'-(3,5-dimethyladamantan-1-yl)urea
Homo sapiens
pH and temperature not specified in the publication
0.01
N-(benzyloxy)-2-(adamant-2-ylamino)acetamide
Homo sapiens
IC50 above 0.01 mM, in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.00096
N-(biphenyl-3-yl)-1,2-benzoxazol-3-amine
Homo sapiens
-
0.000006 - 0.000007
N-(biphenyl-3-yl)-3-methyl-3-phenylpiperidine-1-carboxamide
0.00017
N-(biphenyl-4-yl)-1,2-benzoxazol-3-amine
Homo sapiens
-
0.0000126
N-(cyclohexylmethyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.0000058
N-(cyclohexylmethyl)-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00084
N-(naphthalen-1-yl)-1,2-benzoxazol-3-amine
Homo sapiens
-
0.0000394
N-(naphthalen-1-ylmethyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.0012
N-(naphthalen-2-yl)-1,2-benzoxazol-3-amine
Homo sapiens
-
0.0000012
N-([1-(phenylcarbonyl)piperidin-4-yl]methyl)-N'-(adamant-1-yl) urea
Homo sapiens
-
0.0000032
N-([1-(trifluoroacetyl)piperidin-4-yl]methyl)-N'-(adamant-1-yl) urea
Homo sapiens
-
0.1
N-acetyl-D-galactosamine 4-sulfate
Homo sapiens
-
IC50 is above 0.1 mM
0.0000051 - 0.0001069
N-adamantan-1-yl-N'-(3,5,7-trimethyladamantan-1-yl)urea
0.0000096
N-adamantan-1-yl-N'-(3,5-dimethyladamantan-1-yl)urea
Homo sapiens
pH 7.4, 37°C
0.000005 - 0.000084
N-adamantan-1-yl-N'-(5-hydroxypentyl)urea
0.0000024 - 0.0000027
N-adamantan-1-yl-N'-[(3-ethyladamantan-1-yl)methyl]urea
0.000003 - 0.000014
N-adamantan-1-yl-N'-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]urea
0.000006 - 0.000015
N-adamantan-1-yl-N'-[5-[2-(2-hydroxyethoxy)ethoxy]pentyl]urea
0.0023
N-adamantyl-N'-cyclohexylurea
Strongylocentrotus purpuratus
recombinant SPEH1
0.01
N-benzyl-1,3-benzothiazol-2-amine
Homo sapiens
above
0.01
N-benzyl-1,3-benzoxazol-2-amine
Homo sapiens
above
0.000042
N-benzyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.0002
N-benzyl-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.003
N-benzyl-3-(hydroxymethyl)piperidine-1-carboxamide
Rattus norvegicus
-
0.01
N-benzyl-4-phenylpyridin-2-amine
Homo sapiens
above
0.01
N-benzyl-5-phenyl-1,3,4-oxadiazol-2-amine
Homo sapiens
above
0.01
N-benzyl-5-phenylpyrazin-2-amine
Homo sapiens
above
0.01
N-benzyl-5-phenylpyridin-2-amine
Homo sapiens
above
0.00005 - 0.0012
N-benzyl-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.01
N-benzylquinoxalin-2-amine
Homo sapiens
above
0.001
N-benzyltricyclo[3.3.1.13,7]decane-1-carboxamide
Homo sapiens
IC50 above 0.001 mM, in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.000029
N-cyclobutyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000079
N-cycloheptyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
0.0000026
N-cycloheptyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00069 - 0.00091
N-cyclohexyl(dodecylamino)carboxamide
0.0000164
N-cyclohexyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.000102
N-cyclohexyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00014
N-cyclohexyl-N'-(4-iodophenyl)urea
Homo sapiens
recombinant enzyme, pH 7.0, 22°C
0.05
N-cyclohexyl-N'-ethylurea
0.0000028
N-cyclooctyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000373
N-cyclopentyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.0000052
N-cyclopentyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0000046
N-cyclopropyl-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00008
N-methoxy-N-methyl 3-[4-(N-((2-trifluoromethyl)benzyl)-benzamide)]cyclopropanecarboxamide
Homo sapiens
pH 7.0, 22°C
2.2
N-methyl-1-[3-(pyridin-3-yl)phenyl]methanamine
Homo sapiens
37°C, pH 7.0
0.0002
N-naphthalen-1-yl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.002
N-phenyl-5-(trifluoromethyl)-1,3,4-oxadiazol-2-amine
Homo sapiens
-
0.0002
N-piperidin-1-yl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.8
N-[(1-methyl-1H-pyrazol-3-yl)methyl]-2-phenylethan-1-amine
Homo sapiens
37°C, pH 7.0
0.0000144 - 0.0000277
N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-4-methylpiperazine-1-carboxamide
0.0000002 - 0.0000018
N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]piperidine-1-carboxamide
0.000007 - 0.000014
N-[(3'-chlorobiphenyl-4-yl)methyl]-3-methyl-3-phenylpiperidine-1-carboxamide
0.0000028
N-[(3,5-dimethyladamantan-1-yl)methyl]-N'-(3,5,7-trimethyladamantan-1-yl)urea
Homo sapiens
pH 7.4, 37°C
0.0000018
N-[(3-ethyladamantan-1-yl)methyl]-N'-(1-propanoylpiperidin-4-yl)urea
Homo sapiens
pH 7.4, 37°C
0.0000606
N-[(3-ethyladamantan-1-yl)methyl]-N'-1,3,5-triazatricyclo[3.3.1.13,7]decan-7-ylurea
Homo sapiens
pH 7.4, 37°C
0.0000172
N-[(adamantan-1-yl)methyl]-2-[3-(adamantan-1-yl)propyl]hydrazine-1-carboxamide
Homo sapiens
pH 7.4, 37°C
0.0000397
N-[(adamantan-1-yl)methyl]-4-[([[(adamantan-1-yl)methyl]carbamoyl]amino)methyl]piperidine-1-carboxamide
Homo sapiens
pH 7.4, 37°C
0.0000008
N-[(adamantan-1-yl)methyl]-N'-(1-propanoylpiperidin-4-yl)urea
Homo sapiens
pH 7.4, 37°C
0.001992
N-[(adamantan-1-yl)methyl]-N'-[2-(adamantan-1-yl)pentyl]urea
Homo sapiens
pH 7.4, 37°C
0.0000122
N-[(adamantan-1-yl)methyl]-N'-[4-(adamantan-1-yl)phenyl]urea
Homo sapiens
pH 7.4, 37°C
0.0000291
N-[1-(4-chlorophenyl)ethyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.0000254
N-[1-(adamantan-1-yl)ethyl]-N'-(3,5,7-trimethyladamantan-1-yl)urea
Homo sapiens
pH 7.4, 37°C
0.0000128
N-[1-(adamantan-1-yl)ethyl]-N'-[(3-ethyladamantan-1-yl)methyl]urea
Homo sapiens
pH 7.4, 37°C
0.0000013
N-[1-(phenylcarbonyl)piperidin-4-yl]-N'-(adamant-1-yl) urea
Homo sapiens
-
0.0000018
N-[1-(pyridin-2-ylcarbonyl)piperidin-4-yl]-N'-(adamant-1-yl) urea
Homo sapiens
-
0.0000229
N-[2-(adamantan-1-yl)butyl]-N'-(3,5,7-trimethyladamantan-1-yl)urea
Homo sapiens
pH 7.4, 37°C
0.0000138
N-[2-(adamantan-1-yl)butyl]-N'-(3,5-dimethyladamantan-1-yl)urea
Homo sapiens
pH 7.4, 37°C
0.0000044
N-[2-(adamantan-1-yl)ethyl]-N'-[(adamantan-1-yl)methyl]urea
Homo sapiens
pH 7.4, 37°C
0.0000031
N-[2-(adamantan-1-yl)pentyl]-N'-(3-chloroadamantan-1-yl)urea
Homo sapiens
pH 7.4, 37°C
0.00016 - 0.00027
N-[2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.171
N-[2-(morpholin-4-yl)phenyl]thiophene-3-carboxamide
Homo sapiens
in 25 mM Bis-Tris HCl, pH 7.0, and 0.02% (v/v) Triton X-100, at 22°C
0.0000046 - 0.000006
N-[2-(trifluoromethoxy)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.0052
N-[2-(trifluoromethoxy)phenyl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.000096
N-[2-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.000021 - 0.00018
N-[2-chloro-4-(1H-tetrazol-5-yl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.000014 - 0.000019
N-[2-chloro-4-(methylsulfamoyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.000015 - 0.000016
N-[2-chloro-4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.0000287
N-[2-chloro-5-(trifluoromethyl)benzyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.000185
N-[2-[4-(benzyloxy)phenyl]ethyl]-2-hydroxy-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
Homo sapiens
-
-
0.000011
N-[2-[4-(benzyloxy)phenyl]ethyl]-2-hydroxy-4-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]butanamide
Homo sapiens
-
-
0.00154
N-[2-[4-(benzyloxy)phenyl]ethyl]-2-oxo-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
Homo sapiens
-
-
0.000685
N-[2-[4-(benzyloxy)phenyl]ethyl]-2-oxo-4-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]butanamide
Homo sapiens
-
-
0.000005 - 0.000006
N-[3,3-bis-(4-fluorophenyl)-propyl]-2-(2,2,2-trifluoro-ethoxy)-isonicotinamide
0.000005 - 0.000007
N-[3,3-bis-(4-fluorophenyl)-propyl]-4-methanesulfonyl-benzamide
0.000005 - 0.000009
N-[3,3-bis-(4-fluorophenyl)-propyl]-6-(2,2,2-trifluoro-ethoxy)-nicotinamide
0.000005 - 0.000007
N-[3,3-bis-(4-fluorophenyl)-propyl]-6-hydroxy-nicotinamide
0.0000051 - 0.0000076
N-[3,3-bis-(4-fluorophenyl)-propyl]-benzamide
0.0000072 - 0.000008
N-[3,3-bis-(4-fluorophenyl)-propyl]-nicotinamide
0.002
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-oxo-2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]acetamide
Homo sapiens
-
IC50 above 0.02 mM
0.000049
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-oxo-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
Homo sapiens
-
-
0.000048
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-oxo-4-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]butanamide
Homo sapiens
-
-
0.000055
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-[4-(trifluoromethyl)phenyl]acetamide
Homo sapiens
-
-
0.000093
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-4-(trifluoromethyl)benzamide
Homo sapiens
-
-
0.015
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-4-(trifluoromethyl)benzenesulfonamide
Homo sapiens
-
-
0.0036
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-N'-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]sulfamide
Homo sapiens
-
-
0.0000025
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-N-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-ylmethyl]formamide
Homo sapiens
-
-
0.000088
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-N-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]formamide
Homo sapiens
-
-
0.00011
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-N2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]glycinamide
Homo sapiens
-
-
0.00039
N-[3-(3-morpholin-4-ylpropoxy)phenyl]cyclohexanecarboxamide
Homo sapiens
-
-
0.000007 - 0.000008
N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-4-methanesulfonyl-benzamide
0.000004 - 0.000006
N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-(2,2,2-trifluoro-ethoxy)-nicotinamide
0.000008 - 0.000014
N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-nicotinamide
0.00016
N-[3-(trifluoromethoxy)phenyl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.000043
N-[3-carbamoyl-4-(piperidin-1-yl)phenyl]-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00034
N-[3-[(2',4'-difluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide
Homo sapiens
-
0.000001 - 0.000005
N-[3-[2-(4-chlorophenyl)ethyl]benzyl]-3-methyl-3-phenylpiperidine-1-carboxamide
0.000006 - 0.000007
N-[4-(1H-indol-5-yl)benzyl]-3-methyl-3-phenylpiperidine-1-carboxamide
0.00022 - 0.00027
N-[4-(3-benzoyloxiran-2-yl)phenyl]acetamide
0.00031
N-[4-(benzyloxy)phenyl]-2-hydroxy-2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]acetamide
Homo sapiens
-
-
0.00027
N-[4-(benzyloxy)phenyl]-2-hydroxy-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
Homo sapiens
-
-
0.00021
N-[4-(benzyloxy)phenyl]-2-oxo-2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]acetamide
Homo sapiens
-
-
0.0011
N-[4-(benzyloxy)phenyl]-2-oxo-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
Homo sapiens
-
-
0.000025 - 0.00011
N-[4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.00006
N-[4-(trifluoromethoxy)phenyl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.003
N-[4-(trifluoromethoxy)phenyl]-1,4'-bipiperidine-1'-carboxamide
Rattus norvegicus
-
0.000024
N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide
Rattus norvegicus
-
0.0012
N-[4-(trifluoromethyl)benzyl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.0025
N-[4-(trifluoromethyl)phenyl]-1,2-benzothiazol-3-amine
Homo sapiens
-
0.000025
N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.01
N-[4-(trifluoromethyl)phenyl]-1H-indazol-3-amine
Homo sapiens
above
0.0011
N-[4-(trifluoromethyl)phenyl][1,2]oxazolo[4,5-b]pyridin-3-amine
Homo sapiens
-
0.000027
N-[4-(trifluoromethyl)phenyl][1,2]oxazolo[5,4-b]pyridin-3-amine
Homo sapiens
-
0.000031
N-[4-(trifluoromethyl)phenyl][1,2]oxazolo[5,4-c]pyridin-3-amine
Homo sapiens
-
0.0000263
N-[4-([[(adamantan-1-yl)methyl]carbamoyl]amino)butyl]-N'-[(3,5-dimethyladamantan-1-yl)methyl]urea
Homo sapiens
pH and temperature not specified in the publication
0.00078
N-[4-([[(adamantan-1-yl)methyl]carbamoyl]amino)phenyl]-N'-[(3,5-dimethyladamantan-1-yl)methyl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000011 - 0.000066
N-[4-chloro-2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.000173
N-[4-chloro-3-(trifluoromethyl)benzyl]-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.000078
N-[4-chloro-3-(trifluoromethyl)phenyl]-1-[(2,4-dimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000003
N-[4-fluoro-2-(trifluoromethyl)benzyl]-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0000008
N-[4-[3-(morpholin-4-yl)propoxy]phenyl]-N'-[4-(trifluoromethyl)phenyl]urea
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.00008 - 0.00087
N-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-N'-(4-hydroxyadamantan-1-yl)urea
0.0000004
N-[6-([[(adamantan-1-yl)methyl]carbamoyl]amino)hexyl]-N'-[(3,5-dimethyladamantan-1-yl)methyl]urea
Homo sapiens
pH and temperature not specified in the publication
0.0000073
N-[8-([[(adamantan-1-yl)methyl]carbamoyl]amino)octyl]-N'-[(3,5-dimethyladamantan-1-yl)methyl]urea
Homo sapiens
pH and temperature not specified in the publication
0.000015
N-[[2-chloro-4-(methanesulfonyl)phenyl]methyl]-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.0000043 - 0.000012
N-[[4'-(methylsulfonyl)biphenyl-4-yl]methyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.002006
N1,N4-bis[(adamantan-1-yl)methyl]piperazine-1,4-dicarboxamide
Homo sapiens
pH 7.4, 37°C
0.00021
N1-(2,4-dichlorobenzyl)-N4-(2-methoxyethyl)piperidine-1,4-dicarboxamide
Rattus norvegicus
-
0.00018
N1-(2,4-dichlorobenzyl)-N4-(tetrahydro-2H-pyran-4-yl)piperidine-1,4-dicarboxamide
Rattus norvegicus
-
0.00023
N1-(2,4-dichlorobenzyl)-N4-[2-(methylsulfonyl)ethyl]piperidine-1,4-dicarboxamide
Rattus norvegicus
-
0.00022
N1-(2,4-dichlorobenzyl)-N4-[2-(pyrrolidin-1-yl)ethyl]piperidine-1,4-dicarboxamide
Rattus norvegicus
-
0.00015
N1-(2,4-dichlorobenzyl)-N4-[2-(tetrahydro-2H-pyran-4-yl)ethyl]piperidine-1,4-dicarboxamide
Rattus norvegicus
-
0.00022
N1-(2,4-dichlorobenzyl)piperidine-1,4-dicarboxamide
Rattus norvegicus
-
0.0000079
N1-(4-((2-adamantylacetamido)methyl)phenyl)-N1-methyl-N2-methyl-N2-methyloxyoxalamide
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.000069
N1-(4-((2-adamantylacetamido)methyl)phenyl)-N2-methyl-N2-methyloxyoxalamide
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.0000044
N1-(4-(2-adamantylacetamido)phenyl)-N1-methyl-N2-methyl-N2-(methyloxy)oxalamide
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.000035
N1-(4-(2-adamantylacetamido)phenyl)-N2-methyl-N2-(methyloxy)oxalamide
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.01
N1-(adamant-1-yl)-N2-(benzyloxy)oxalamide
Homo sapiens
IC50 above 0.01 mM, in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.000838
N1-(adamant-1-ylmethyl)-N2-(benzyloxy)oxalamide
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.0044
N1-(adamant-2-yl)-N2-(2-phenylethyloxy)oxalamide
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.00055
N1-(adamant-2-yl)-N2-(3-phenylpropyloxy)oxalamide
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.0023
N1-(adamant-2-yl)-N2-(4-chlorobenzyloxy)oxalamide
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.0015
N1-(adamant-2-yl)-N2-(4-methoxycarbonylbenzyloxy)oxalamide
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.01
N1-(adamant-2-yl)-N2-(4-nitrobenzyloxy)oxalamide
Homo sapiens
IC50 above 0.01 mM, in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.0032
N1-(adamant-2-yl)-N2-(benzyloxy)-N2-methyloxalamide
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.00005
N1-(adamant-2-yl)-N2-(benzyloxy)oxalamide
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.01
N1-(adamant-2-yl)-N2-(phenyloxy)oxalamide
Homo sapiens
IC50 above 0.01 mM, in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.01
N1-(adamant-2-yl)-N2-(tetrahydro-2H-pyran-2-yloxy)oxalamide
Homo sapiens
IC50 above 0.01 mM, in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.01
N1-(adamant-2-yl)-N2-methyl-N2-(methyloxy)oxalamide
Homo sapiens
IC50 above 0.01 mM, in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.00005
N1-(adamantan-1-yl)-N2-(benzyloxy)ethanediamide
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.01
N1-(benzyloxy)-N2-(3-phenylpropyl)oxalamide
Homo sapiens
IC50 above 0.01 mM, in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.021
octadecan-9-yl sulfate
Homo sapiens
-
IC50 is 0.021 mM
0.0126 - 0.022
phenyl(3-phenyloxiran-2-yl)methanol
0.0003 - 0.0029
phenyl(3-phenyloxiran-2-yl)methanone
0.0001 - 0.00043
pyridine-2-carboxylic acid (3,3-diphenyl-propyl)-amide
0.003
pyridine-3-sulfonic acid 3,3-(diphenylpropyl)-amide
0.029
racemic 2,3-epoxy-1,3-diphenyl-1-propanol
Mus musculus
-
IC50 is 0.029 mM
0.032
racemic 2,3-epoxy-3-(4-fluorophenyl)-1-phenyl-1-propanol
Mus musculus
-
IC50 is 0.032 mM
0.0017
racemic 2,3-epoxy-3-(4-nitrophenyl)-1-phenyl-1-propanol
Mus musculus
-
IC50 is 0.0017 mM
0.012
racemic 3,4-epoxy-4-(4-nitrophenyl)-1-butanol
Mus musculus
-
IC50 is 0.012 mM
0.005
racemic 3-(4-nitrophenyl)glycidol
Mus musculus
-
IC50 is 0.005 mM
0.1
Sodium dodecyl sulfate
Homo sapiens
-
IC50 is above 0.1 mM
0.05
sodium dodecyl sulfonate
Homo sapiens
-
IC50 is 0.05 mM
0.0000069
t-butyl 4-[2-[(5-chloro-1,3-benzoxazol-2-yl)amino]-2-oxoethyl]piperidine-1-carboxylate
Homo sapiens
pH 7.4, 22°C
0.09
taurocholic acid
Homo sapiens
-
IC50 is 0.09 mM
0.1
taurolithocholic acid 3-sulfate
Homo sapiens
-
IC50 is above 0.1 mM
0.000263
tert-butyl 4-[([1-[(2,4-dimethylphenyl)sulfonyl]piperidin-4-yl]carbonyl)amino]piperidine-1-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.1
tetraisopropyl methylenediphosphonate
Homo sapiens
-
IC50 is above 0.1 mM
3.9
trans-(2R,3R)-3-phenylglycidol
Mus musculus
-
IC50 for the R-enantiomer is about 3.9 mM
2.2
trans-(2S,3S)-3-phenylglycidol
Mus musculus
-
IC50 for the S-enantiomer is about 2.2 mM
0.0000017
trans-1-adamantan-1-yl-3-(4-benzyloxycyclohexyl)urea
Homo sapiens
pH 7.4, 30°C
0.0000017
trans-1-adamantan-1-yl-3-[4-(2,6-dichlorobenzyloxy)cyclohexyl]-urea
Homo sapiens
pH 7.4, 30°C
0.0000017
trans-1-adamantan-1-yl-3-[4-(2,6-difluorobenzyloxy)cyclohexyl]-urea
Homo sapiens
pH 7.4, 30°C
0.0000016
trans-1-adamantan-1-yl-3-[4-(2-methylbenzyloxy)cyclohexyl]-urea
Homo sapiens
pH 7.4, 30°C
0.000001
trans-1-adamantan-1-yl-3-[4-(3,5-difluorophenoxy)cyclohexyl]-urea
Homo sapiens
pH 7.4, 30°C
0.0000017
trans-1-adamantan-1-yl-3-[4-(4-bromobenzyloxy)cyclohexyl]-urea
Homo sapiens
pH 7.4, 30°C
2.98 - 3.47
trans-1-phenylpropylene oxide
1.52 - 2
trans-2-methyl-3-phenylglycidol
0.12 - 0.77
trans-3-(4-bromophenyl)glycidol
0.013 - 4.24
trans-3-(4-nitrophenyl)glycidol
0.232 - 0.39
trans-3-(4-nitrophenyl)glycidyl acetate
0.1 - 0.229
trans-3-(4-nitrophenyl)glycidyl benzoate
0.0000013
trans-4-(4-(3-adamantan-1-yl-ureido)-cyclohexyloxy)-benzoic acid
Homo sapiens
-
0.0000009
trans-4-(4-[3-(4-trifluoromethoxyphenyl)ureido]cyclohexyloxy)benzoic acid
Homo sapiens
pH 7.4, 30°C
0.0000013 - 0.000008
trans-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
0.000001 - 0.000008
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
0.000052 - 0.000398
[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]acetic acid
0.00013 - 0.00016
[3-(2-naphthyl)oxiran-2-yl](4-nitrophenyl)methanone
0.00051 - 0.00072
[3-(2-naphthyl)oxiran-2-yl](phenyl)methanol
0.00014 - 0.00085
[3-(2-naphthyl)oxiran-2-yl](phenyl)methanone
0.0002 - 0.0007
[3-(4-bromophenyl)oxiran-2-yl](phenyl)methanone
0.00015
[3-(4-butylphenyl)oxiran-2-yl](phenyl)methanone
0.018 - 0.072
[3-(4-fluorophenyl)oxiran-2-yl](phenyl)methanol
0.0003 - 0.0013
[3-(4-fluorophenyl)oxiran-2-yl](phenyl)methanone
0.00048 - 0.00065
[3-(4-heptylphenyl)oxiran-2-yl](phenyl)methanone
0.00047 - 0.00048
[3-(4-isopropylphenyl)oxiran-2-yl](phenyl)methanone
0.00011 - 0.0002
[3-(4-methoxyphenyl)oxiran-2-yl](phenyl)methanone
0.00036 - 0.0019
[3-(4-methylphenyl)oxiran-2-yl](phenyl)methanone
0.0037 - 0.028
[3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanol
0.00063 - 0.0018
[3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanone
0.00014 - 0.00051
[3-(4-phenoxycyclohexa-1,5-dien-1-yl)oxiran-2-yl](phenyl)methanone
0.00014 - 0.0014
[4-(allyloxy)phenyl](3-phenyloxiran-2-yl)methanone
0.00011 - 0.00016
[4-(bromomethyl)phenyl][3-(2-naphthyl)oxiran-2-yl]methanone
0.000002 - 0.000019
[6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl][4-(trifluoromethyl)phenyl]methanone
0.005
[N-(2-(trifluoromethyl)benzyl)benzamide]-4-(1H-tetrazole)
Homo sapiens
pH 7.0, 22°C
0.00006 - 0.5
additional information
-
0.00029
(3-[4-(allyloxy)phenyl]oxiran-2-yl)(phenyl)methanone
Homo sapiens
-
IC50 is 0.00029 mM
0.0021
(3-[4-(allyloxy)phenyl]oxiran-2-yl)(phenyl)methanone
Mus musculus
-
IC50 is 0.0021 mM
0.00023
(3-[4-(benzyloxy)phenyl]oxiran-2-yl)(phenyl)methanone
Homo sapiens
-
IC50 is 0.00023 mM
0.00028
(3-[4-(benzyloxy)phenyl]oxiran-2-yl)(phenyl)methanone
Mus musculus
-
IC50 is 0.00028 mM
0.0000002
(3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(4-fluorobenzene-1-sulfonyl)amino]piperidine-1-carboxamide
Rattus norvegicus
pH and temperature not specified in the publication
0.0000007
(3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(4-fluorobenzene-1-sulfonyl)amino]piperidine-1-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.0000008
(3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(methanesulfonyl)amino]piperidine-1-carboxamide
Rattus norvegicus
pH and temperature not specified in the publication
0.0000014
(3R)-N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-3-[(methanesulfonyl)amino]piperidine-1-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.00022
(4-bromophenyl)(3-phenyloxiran-2-yl)methanone
Homo sapiens
-
IC50 is 0.00022 mM
0.0006
(4-bromophenyl)(3-phenyloxiran-2-yl)methanone
Mus musculus
-
IC50 is 0.0006 mM
0.00014
(4-bromophenyl)[3-(2-naphthyl)oxiran-2-yl]methanone
Mus musculus
-
IC50 is 0.00014 mM
0.00018
(4-bromophenyl)[3-(2-naphthyl)oxiran-2-yl]methanone
Homo sapiens
-
IC50 is 0.00018 mM
0.00039
(4-fluorophenyl)(3-phenyloxiran-2-yl)methanone
Homo sapiens
-
IC50 is 0.00039 mM
0.0018
(4-fluorophenyl)(3-phenyloxiran-2-yl)methanone
Mus musculus
-
IC50 is 0.0018 mM
0.00042
(4-iodophenyl)(3-phenyloxiran-2-yl)methanone
Homo sapiens
-
IC50 is 0.00042 mM
0.0014
(4-iodophenyl)(3-phenyloxiran-2-yl)methanone
Mus musculus
-
IC50 is 0.0014 mM
0.0002
(4-methoxyphenyl)(3-phenyloxiran-2-yl)methanone
Homo sapiens
-
IC50 is 0.00020 mM
0.00032
(4-methoxyphenyl)(3-phenyloxiran-2-yl)methanone
Mus musculus
-
IC50 is 0.00032 mM
0.00023
(4-methylphenyl)(3-phenyloxiran-2-yl)methanone
Homo sapiens
-
IC50 is 0.00023 mM
0.0017
(4-methylphenyl)(3-phenyloxiran-2-yl)methanone
Mus musculus
-
IC50 is 0.0017 mM
0.00009
(4-methylphenyl)[3-(2-naphthyl)oxiran-2-yl]methanol
Mus musculus
-
IC50 is 0.00009 mM
0.00015
(4-methylphenyl)[3-(2-naphthyl)oxiran-2-yl]methanol
Homo sapiens
-
IC50 is 0.00015 mM
0.0001
(4-methylphenyl)[3-(2-naphthyl)oxiran-2-yl]methanone
Mus musculus
-
IC50 is 0.00010 mM
0.00019
(4-methylphenyl)[3-(2-naphthyl)oxiran-2-yl]methanone
Homo sapiens
-
IC50 is 0.00019 mM
0.00025
(4-nitrophenyl)(3-phenyloxiran-2-yl)methanone
Homo sapiens
-
IC50 is 0.00025 mM
0.0015
(4-nitrophenyl)(3-phenyloxiran-2-yl)methanone
Mus musculus
-
IC50 is 0.0015 mM
0.00029
(E)-phenyl(3-phenyloxiran-2-yl)methanone oxime
Homo sapiens
-
IC50 is 0.00029 mM
0.0035
(E)-phenyl(3-phenyloxiran-2-yl)methanone oxime
Mus musculus
-
IC50 is 0.0035 mM
0.035
(E)-[3-(2-naphthyl)oxiran-2-yl](phenyl)methanone oxime
Homo sapiens
-
IC50 is 0.035 mM
0.042
(E)-[3-(2-naphthyl)oxiran-2-yl](phenyl)methanone oxime
Mus musculus
-
IC50 is 0.042 mM
0.000014
(R)-4-cyano-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-benzamide
Homo sapiens
-
0.000024
(R)-4-cyano-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-benzamide
Rattus norvegicus
-
0.000023
(R)-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-hydroxy-nicotinamide
Homo sapiens
-
0.000087
(R)-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-hydroxy-nicotinamide
Rattus norvegicus
-
0.000006
(S)-4-cyano-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-benzamide
Rattus norvegicus
-
0.000008
(S)-4-cyano-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-benzamide
Homo sapiens
-
0.000006
(S)-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-hydroxy-nicotinamide
Homo sapiens
-
0.000007
(S)-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-hydroxy-nicotinamide
Rattus norvegicus
-
0.000028
1-(1-acetylpiperidin-4-yl)-3-cycloheptylurea
Homo sapiens
-
0.000035
1-(1-acetylpiperidin-4-yl)-3-cycloheptylurea
Rattus norvegicus
-
0.000003
1-(1-methylsulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)-urea
Homo sapiens
-
-
0.000005
1-(1-methylsulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)-urea
Mus musculus
-
-
0.000206
1-(2-hydroxyphenyl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
Homo sapiens
recombinant enzyme expressed in Escherichia coli
0.000258
1-(2-hydroxyphenyl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
Homo sapiens
recombinant enzyme expressed in Sf9 cells
0.000007
1-(3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)-3-phenylpropan-1-one
Homo sapiens
-
0.00001
1-(3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl)-3-phenylpropan-1-one
Rattus norvegicus
-
0.000613
1-(3-hydroxypropyl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
Homo sapiens
recombinant enzyme expressed in Escherichia coli
0.000813
1-(3-hydroxypropyl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
Homo sapiens
recombinant enzyme expressed in Sf9 cells
0.00012
1-(5-hydroxypentyl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
Homo sapiens
recombinant enzyme expressed in Escherichia coli
0.000128
1-(5-hydroxypentyl)-3-tricyclo[3.3.1.13,7]dec-1-ylurea
Homo sapiens
recombinant enzyme expressed in Sf9 cells
0.000002
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
Mesocricetus auratus
-
pH 7.5, 30°C
0.000003
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
Mus musculus
-
pH 7.5, 30°C
0.000005
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
Rattus norvegicus
-
pH 7.5, 30°C
0.000014
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
Homo sapiens
pH 7.4, 30°C
0.000027
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
Felis catus
-
pH 7.5, 30°C
0.000086
1-adamantan-1-yl-3-(5-[2-(2-ethoxyethoxy)ethoxy]pentyl)urea
Canis lupus
-
pH 7.5, 30°C
0.000003
1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea
Mus musculus
-
purified recombinant enzyme
0.000014
1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea
Homo sapiens
-
purified recombinant enzyme
0.000019
1-cyclohexyl-3-dodecyl urea
Homo sapiens
-
pH 7.0, 23°C
0.0000852
1-cyclohexyl-3-dodecyl urea
Homo sapiens
-
0.000012
1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl)urea
Homo sapiens
-
in bis-Tris/HCl buffer, pH 7.0, at 25°C
0.000079
1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl)urea
Rattus norvegicus
-
in bis-Tris/HCl buffer, pH 7.0, at 25°C
0.000097
1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl)urea
Mus musculus
-
in bis-Tris/HCl buffer, pH 7.0, at 25°C
0.0023
1-[3-(4-nitrophenyl)oxiran-2-yl]ethanol
Mus musculus
-
IC50 is 0.0023 mM
0.0187
1-[3-(4-nitrophenyl)oxiran-2-yl]ethanol
Homo sapiens
-
IC50 is 0.0187 mM
0.163
1-[3-(4-nitrophenyl)oxiran-2-yl]ethanone
Mus musculus
-
IC50 is 0.163 mM
0.269
1-[3-(4-nitrophenyl)oxiran-2-yl]ethanone
Homo sapiens
-
IC50 is 0.269 mM
0.0004
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[3-(trifluoromethoxy)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00063
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[3-(trifluoromethoxy)benzyl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000008
1-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
Homo sapiens
recombinant enzyme expressed in Escherichia coli
0.000009
1-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
Homo sapiens
recombinant enzyme expressed in Sf9 cells
0.000014
1-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-3-tricyclo[3.3.1.13,7]dec-1-ylurea
Homo sapiens
-
0.000003
12-(3-adamantan-1-yl-ureido)dodecanoic acid
Homo sapiens
-
purified recombinant enzyme
0.0000032
12-(3-adamantan-1-yl-ureido)dodecanoic acid
Homo sapiens
in 25 mM Bis-Tris/HCl, pH 7.0, at 30°C
0.00001
12-(3-adamantan-1-yl-ureido)dodecanoic acid
Mus musculus
-
purified recombinant enzyme
0.000107
12-(3-adamantan-1-yl-ureido)dodecanoic acid
Homo sapiens
-
in 25 mM Bis-Tris-HCl, pH 7.0, at 37°C
0.000003
12-(3-adamantan-1-ylureido)dodecanoic acid
Homo sapiens
-
in bis-Tris/HCl buffer, pH 7.0, at 25°C
0.00001
12-(3-adamantan-1-ylureido)dodecanoic acid
Mus musculus
-
in bis-Tris/HCl buffer, pH 7.0, at 25°C
0.000011
12-(3-adamantan-1-ylureido)dodecanoic acid
Rattus norvegicus
-
in bis-Tris/HCl buffer, pH 7.0, at 25°C
0.0000008
12-(3-adamantan-1-ylureido)dodecanoic acid butyl ester
Homo sapiens
-
in bis-Tris/HCl buffer, pH 7.0, at 25°C
0.000004
12-(3-adamantan-1-ylureido)dodecanoic acid butyl ester
Mus musculus
-
in bis-Tris/HCl buffer, pH 7.0, at 25°C
0.000005
12-(3-adamantan-1-ylureido)dodecanoic acid butyl ester
Rattus norvegicus
-
in bis-Tris/HCl buffer, pH 7.0, at 25°C
0.0000046
12-(3-adamantane-1-yl-ureido)-dodecanoic acid
Homo sapiens
-
pH 7.0, 23°C
0.000057
12-(3-adamantane-1-yl-ureido)-dodecanoic acid
Strongylocentrotus purpuratus
recombinant SPEH1
0.000059
12-(3-adamantane-1-yl-ureido)-dodecanoic acid
Strongylocentrotus purpuratus
crude extract from gonads
0.0000022
12-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]dodecanoic acid
Homo sapiens
recombinant enzyme expressed in Escherichia coli
0.0000023
12-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]dodecanoic acid
Homo sapiens
recombinant enzyme expressed in Sf9 cells
0.000003
12-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamoyl)amino]dodecanoic acid
Homo sapiens
-
0.000002
12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid
Homo sapiens
pH 7.0, 37°C
0.000059
12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.0029
2,3-epoxy-1,3-diphenyl-propan-1-one
Mus musculus
-
IC50: 0.0029 mM
0.0034
2,3-epoxy-1,3-diphenyl-propan-1-one
Solanum tuberosum
-
IC50: 0.0034 mM
0.023
2,3-epoxy-1,3-diphenyl-propan-1-one
Arabidopsis thaliana
-
IC50: 0.023 mM
0.0006
2,3-epoxy-1-(4-bromophenyl)-3-phenyl-propan-1-one
Mus musculus
-
IC50: 0.0006 mM
0.00089
2,3-epoxy-1-(4-bromophenyl)-3-phenyl-propan-1-one
Solanum tuberosum
-
IC50: 0.00089 mM
0.013
2,3-epoxy-1-(4-bromophenyl)-3-phenyl-propan-1-one
Arabidopsis thaliana
-
IC50: 0.013 mM
0.0014
2,3-epoxy-1-(4-ethylphenyl)-3-phenyl-propan-1-one
Solanum tuberosum
-
IC50: 0.0014 mM
0.0017
2,3-epoxy-1-(4-ethylphenyl)-3-phenyl-propan-1-one
Mus musculus
-
IC50: 0.0017 mM
0.03
2,3-epoxy-1-(4-ethylphenyl)-3-phenyl-propan-1-one
Arabidopsis thaliana
-
IC50: 0.03 mM
0.0012
2,3-epoxy-1-(4-fluorophenyl)-3-phenyl-propan-1-one
Solanum tuberosum
-
IC50: 0.0012 mM
0.0018
2,3-epoxy-1-(4-fluorophenyl)-3-phenyl-propan-1-one
Mus musculus
-
IC50: 0.0018 mM
0.022
2,3-epoxy-1-(4-fluorophenyl)-3-phenyl-propan-1-one
Arabidopsis thaliana
-
IC50: 0.022 mM
0.00021
2,3-epoxy-1-(4-methoxyphenyl)-3-phenyl-propan-1-one
Solanum tuberosum
-
IC50: 0.00021 mM
0.00032
2,3-epoxy-1-(4-methoxyphenyl)-3-phenyl-propan-1-one
Mus musculus
-
IC50: 0.00032 mM
0.0054
2,3-epoxy-1-(4-methoxyphenyl)-3-phenyl-propan-1-one
Arabidopsis thaliana
-
IC50: 0.0054 mM
0.0015
2,3-epoxy-1-(4-nitroxyphenyl)-3-phenyl-propan-1-one
Mus musculus
-
IC50: 0.0015 mM
0.016
2,3-epoxy-1-(4-nitroxyphenyl)-3-phenyl-propan-1-one
Arabidopsis thaliana
-
IC50: 0.016 mM
0.019
2,3-epoxy-1-(4-nitroxyphenyl)-3-phenyl-propan-1-one
Solanum tuberosum
-
IC50: 0.019 mM
0.00137
2,3-epoxy-1-(4-phenylphenyl)-3-phenyl-propan-1-one
Mus musculus
-
IC50: 0.00137 mM
0.0025
2,3-epoxy-1-(4-phenylphenyl)-3-phenyl-propan-1-one
Solanum tuberosum
-
IC50: 0.0025 mM
0.00012
2,3-epoxy-3-(4-bromophenyl)-1-phenyl-propan-1-one
Solanum tuberosum
-
IC50: 0.00012 mM
0.0007
2,3-epoxy-3-(4-bromophenyl)-1-phenyl-propan-1-one
Mus musculus
-
IC50: 0.0007 mM
0.0022
2,3-epoxy-3-(4-bromophenyl)-1-phenyl-propan-1-one
Arabidopsis thaliana
-
IC50: 0.0022 mM
0.00016
2,3-epoxy-3-(4-ethylphenyl)-1-phenyl-propan-1-one
Solanum tuberosum
-
IC50: 0.00016 mM
0.0019
2,3-epoxy-3-(4-ethylphenyl)-1-phenyl-propan-1-one
Mus musculus
-
IC50: 0.0019 mM
0.0056
2,3-epoxy-3-(4-ethylphenyl)-1-phenyl-propan-1-one
Arabidopsis thaliana
-
IC50: 0.0056 mM
0.00048
2,3-epoxy-3-(4-fluorophenyl)-1-phenyl-propan-1-one
Solanum tuberosum
-
IC50: 0.00048 mM
0.0013
2,3-epoxy-3-(4-fluorophenyl)-1-phenyl-propan-1-one
Mus musculus
-
IC50: 0.0013 mM
0.0047
2,3-epoxy-3-(4-fluorophenyl)-1-phenyl-propan-1-one
Arabidopsis thaliana
-
IC50: 0.0047 mM
0.00019
2,3-epoxy-3-(4-methoxyphenyl)-1-phenyl-propan-1-one
Solanum tuberosum
-
IC50: 0.00019 mM
0.0002
2,3-epoxy-3-(4-methoxyphenyl)-1-phenyl-propan-1-one
Mus musculus
-
IC50: 0.0002 mM
0.0028
2,3-epoxy-3-(4-methoxyphenyl)-1-phenyl-propan-1-one
Arabidopsis thaliana
-
IC50: 0.0028 mM
0.00015
2,3-epoxy-3-(4-n-butylphenyl)-1-phenyl-propan-1-one
Mus musculus
-
IC50: 0.00015 mM
0.0017
2,3-epoxy-3-(4-n-butylphenyl)-1-phenyl-propan-1-one
Arabidopsis thaliana
-
IC50: 0.0017 mM
0.00018
2,3-epoxy-3-(4-nitrophenyl)-1-phenyl-propan-1-one
Mus musculus
-
IC50: 0.00018 mM
0.00038
2,3-epoxy-3-(4-nitrophenyl)-1-phenyl-propan-1-one
Solanum tuberosum
-
IC50: 0.00038 mM
0.011
2,3-epoxy-3-(4-nitrophenyl)-1-phenyl-propan-1-one
Arabidopsis thaliana
-
IC50: 0.011 mM
0.000001
2-(2,4-dichlorophenyl)-1-[6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl]ethanone
Homo sapiens
-
0.000004
2-(2,4-dichlorophenyl)-1-[6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl]ethanone
Rattus norvegicus
-
0.07
2-(2-naphthyl)-3-(phenylsulfinyl)oxirane
Homo sapiens
-
IC50 is 0.070 mM
0.073
2-(2-naphthyl)-3-(phenylsulfinyl)oxirane
Mus musculus
-
IC50 is 0.073 mM
0.00051
2-([[2-(adamantan-1-yl)ethyl]amino]methyl)phenol
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.00051
2-([[2-(adamantan-1-yl)ethyl]amino]methyl)phenol
Homo sapiens
37°C, pH 7.0
0.00031
2-cyclohexa-1,5-dien-1-yl-3-(phenylsulfinyl)oxirane
Homo sapiens
-
IC50 is 0.00031 mM
0.0023
2-cyclohexa-1,5-dien-1-yl-3-(phenylsulfinyl)oxirane
Mus musculus
-
IC50 is 0.0023 mM
0.034
2-cyclohexa-1,5-dien-1-yl-3-[methoxy(phenyl)methyl]oxirane
Homo sapiens
-
IC50 is 0.034 mM
0.103
2-cyclohexa-1,5-dien-1-yl-3-[methoxy(phenyl)methyl]oxirane
Mus musculus
-
IC50 is 0.103 mM
0.00028
2-naphthyl(3-phenyloxiran-2-yl)methanone
Homo sapiens
-
IC50 is 0.00028 mM
0.0014
2-naphthyl(3-phenyloxiran-2-yl)methanone
Mus musculus
-
IC50 is 0.0014 mM
0.00048
2-[methoxy(phenyl)methyl]-3-(2-naphthyl)oxirane
Mus musculus
-
IC50 is 0.00048 mM
0.00134
2-[methoxy(phenyl)methyl]-3-(2-naphthyl)oxirane
Homo sapiens
-
IC50 is 0.00134 mM
0.000004
3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl[4-(trifluoromethyl)phenyl]methanone
Homo sapiens
-
0.00001
3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl[4-(trifluoromethyl)phenyl]methanone
Rattus norvegicus
-
0.000005
3-(3-amino-3-oxopropyl)-N-(4-chlorophenyl)-3-phenylpiperidine-1-carboxamide
Homo sapiens
-
0.000026
3-(3-amino-3-oxopropyl)-N-(4-chlorophenyl)-3-phenylpiperidine-1-carboxamide
Rattus norvegicus
-
0.000001
3-methyl-3-phenyl-N-(4-(pyridin-3-yl)benzyl)piperidine-1-carboxamide
Homo sapiens
-
0.000003
3-methyl-3-phenyl-N-(4-(pyridin-3-yl)benzyl)piperidine-1-carboxamide
Rattus norvegicus
-
0.000249
3-methyl-3-phenyl-N-(pyridin-4-yl)piperidine-1-carboxamide
Rattus norvegicus
-
0.00055
3-methyl-3-phenyl-N-(pyridin-4-yl)piperidine-1-carboxamide
Homo sapiens
-
0.000006
3-methyl-3-phenyl-N-[3-(pyridin-3-yl)propyl]piperidine-1-carboxamide
Rattus norvegicus
-
0.000007
3-methyl-3-phenyl-N-[3-(pyridin-3-yl)propyl]piperidine-1-carboxamide
Homo sapiens
-
0.000001
3-methyl-3-phenyl-N-[3-[(1S,2S)-2-phenylcyclopropyl]benzyl]piperidine-1-carboxamide
Homo sapiens
-
0.000004
3-methyl-3-phenyl-N-[3-[(1S,2S)-2-phenylcyclopropyl]benzyl]piperidine-1-carboxamide
Rattus norvegicus
-
0.000005
3-methyl-3-phenyl-N-[3-[2-(quinoxalin-6-yl)ethyl]benzyl]piperidine-1-carboxamide
Homo sapiens
-
0.000019
3-methyl-3-phenyl-N-[3-[2-(quinoxalin-6-yl)ethyl]benzyl]piperidine-1-carboxamide
Rattus norvegicus
-
0.000008
3-methyl-3-phenyl-N-[[2'-(trifluoromethyl)biphenyl-4-yl]methyl]piperidine-1-carboxamide
Homo sapiens
-
0.000011
3-methyl-3-phenyl-N-[[2'-(trifluoromethyl)biphenyl-4-yl]methyl]piperidine-1-carboxamide
Rattus norvegicus
-
0.000019
3-[1-[(4-chlorophenyl)carbamoyl]-3-(pyridin-2-yl)piperidin-3-yl]propanoic acid
Homo sapiens
-
0.00029
3-[1-[(4-chlorophenyl)carbamoyl]-3-(pyridin-2-yl)piperidin-3-yl]propanoic acid
Rattus norvegicus
-
0.000028
3-[1-[(4-chlorophenyl)carbamoyl]-3-(pyridin-3-yl)piperidin-3-yl]propanoic acid
Homo sapiens
-
0.000331
3-[1-[(4-chlorophenyl)carbamoyl]-3-(pyridin-3-yl)piperidin-3-yl]propanoic acid
Rattus norvegicus
-
0.00003
3-[1-[(4-chlorophenyl)carbamoyl]-3-(pyridin-4-yl)piperidin-3-yl]propanoic acid
Homo sapiens
-
0.000467
3-[1-[(4-chlorophenyl)carbamoyl]-3-(pyridin-4-yl)piperidin-3-yl]propanoic acid
Rattus norvegicus
-
0.000005
3-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]propanoic acid
Homo sapiens
-
0.000016
3-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]propanoic acid
Homo sapiens
-
0.00007
3-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]propanoic acid
Rattus norvegicus
-
0.000076
3-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]propanoic acid
Rattus norvegicus
-
0.000012
3-[1-[(4-chlorophenyl)carbamoyl]-3-[3-(trifluoromethyl)phenyl]piperidin-3-yl]propanoic acid
Homo sapiens
-
0.000176
3-[1-[(4-chlorophenyl)carbamoyl]-3-[3-(trifluoromethyl)phenyl]piperidin-3-yl]propanoic acid
Rattus norvegicus
-
0.000005
3-[1-[(4-chlorophenyl)carbamoyl]-3-[4-(trifluoromethyl)phenyl]piperidin-3-yl]propanoic acid
Homo sapiens
-
0.00012
3-[1-[(4-chlorophenyl)carbamoyl]-3-[4-(trifluoromethyl)phenyl]piperidin-3-yl]propanoic acid
Rattus norvegicus
-
0.000008
3-[3-(biphenyl-4-yl)-1-[(4-chlorophenyl)carbamoyl]piperidin-3-yl]propanoic acid
Homo sapiens
-
0.000413
3-[3-(biphenyl-4-yl)-1-[(4-chlorophenyl)carbamoyl]piperidin-3-yl]propanoic acid
Rattus norvegicus
-
0.0001
3-[4-[(1-[[(1R,3S)-2,2-dimethyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
Homo sapiens
pH and temperature not specified in the publication
0.0001
3-[4-[(1-[[(1R,3S)-2,2-dimethyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
Rattus norvegicus
pH and temperature not specified in the publication
0.0000191
3-[4-[(1-[[(1S,2R)-2-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
Homo sapiens
pH and temperature not specified in the publication
0.0000556
3-[4-[(1-[[(1S,2R)-2-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
Rattus norvegicus
pH and temperature not specified in the publication
0.0000117
3-[4-[(1-[[(1S,2R,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
Rattus norvegicus
pH and temperature not specified in the publication
0.000012
3-[4-[(1-[[(1S,2R,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
Homo sapiens
pH and temperature not specified in the publication
0.0000021
3-[4-[(1-[[(1s,2R,3S)-2,3-bis(4-fluorophenyl)cyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
Homo sapiens
pH and temperature not specified in the publication
0.0000032
3-[4-[(1-[[(1s,2R,3S)-2,3-bis(4-fluorophenyl)cyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
Rattus norvegicus
pH and temperature not specified in the publication
0.0000023
3-[4-[(1-[[(1s,2R,3S)-2,3-diphenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
Homo sapiens
pH and temperature not specified in the publication
0.0000039
3-[4-[(1-[[(1s,2R,3S)-2,3-diphenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
Rattus norvegicus
pH and temperature not specified in the publication
0.0000757
3-[4-[(1-[[(1S,2S,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
Homo sapiens
pH and temperature not specified in the publication
0.0001
3-[4-[(1-[[(1S,2S,3R)-2-methyl-3-phenylcyclopropyl]carbamoyl]piperidin-4-yl)oxy]phenyl]propanoic acid
Rattus norvegicus
pH and temperature not specified in the publication
0.000008
4'-hydroxy-N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide
Homo sapiens
-
0.000031
4'-hydroxy-N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide
Rattus norvegicus
-
0.000018
4,4-diphenyl-N-(pyridin-3-yl)-butyramide
Rattus norvegicus
-
0.000045
4,4-diphenyl-N-(pyridin-3-yl)-butyramide
Homo sapiens
-
0.5
4-(3-benzoyloxiran-2-yl)benzoic acid
Mus musculus
-
IC50 is above 0.5 mM
0.5
4-(3-benzoyloxiran-2-yl)benzoic acid
Homo sapiens
-
IC50 is above 0.5 mM
0.00008
4-([3-(2-naphthyl)oxiran-2-yl]carbonyl)benzoic acid
Mus musculus
-
IC50 is 0.00008 mM
0.00016
4-([3-(2-naphthyl)oxiran-2-yl]carbonyl)benzoic acid
Homo sapiens
-
IC50 is 0.00016 mM
0.103
4-([3-(4-fluorophenyl)oxiran-2-yl]carbonyl)benzoic acid
Mus musculus
-
IC50 is 0.103 mM
0.113
4-([3-(4-fluorophenyl)oxiran-2-yl]carbonyl)benzoic acid
Homo sapiens
-
IC50 is 0.113 mM
0.00021
4-bromo-4'-methoxychalcone
Solanum tuberosum
-
IC50: 0.00021 mM
0.00027
4-bromo-4'-methoxychalcone
Mus musculus
-
IC50: 0.00027 mM
0.0048
4-bromo-4'-methoxychalcone
Arabidopsis thaliana
-
IC50: 0.0048 mM
0.000005
4-cyano-N-[3,3-bis-(4-fluorophenyl)-propyl]-benzamide
Homo sapiens
-
0.000007
4-cyano-N-[3,3-bis-(4-fluorophenyl)-propyl]-benzamide
Rattus norvegicus
-
0.000003
4-oxo-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Homo sapiens
-
0.000039
4-oxo-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Rattus norvegicus
-
0.000001
4-oxo-N-(2-phenylcyclopropyl)-6-(pyridin-4-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Homo sapiens
-
0.000007
4-oxo-N-(2-phenylcyclopropyl)-6-(pyridin-4-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Rattus norvegicus
-
0.000008
4-oxo-N-(3-phenylcyclopentyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Homo sapiens
-
0.000021
4-oxo-N-(3-phenylcyclopentyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Rattus norvegicus
-
0.00002
4-oxo-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Homo sapiens
-
0.000028
4-oxo-N-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Rattus norvegicus
-
0.000003
4-oxo-N-[(1S,2R)-2-phenylcyclopropyl]-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Homo sapiens
-
0.000009
4-oxo-N-[(1S,2R)-2-phenylcyclopropyl]-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Rattus norvegicus
-
0.073
4-[(3-phenyloxiran-2-yl)carbonyl]benzoic acid
Mus musculus
-
IC50 is 0.073 mM
0.144
4-[(3-phenyloxiran-2-yl)carbonyl]benzoic acid
Homo sapiens
-
IC50 is 0.144 mM
0.000012
4-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]butanoic acid
Homo sapiens
-
0.000176
4-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]butanoic acid
Rattus norvegicus
-
0.5
4-[3-(4-fluorobenzoyl)oxiran-2-yl]benzoic acid
Mus musculus
-
IC50 is above 0.5 mM
0.5
4-[3-(4-fluorobenzoyl)oxiran-2-yl]benzoic acid
Homo sapiens
-
IC50 is above 0.5 mM
0.0000017
4-[[(1r,4r)-4-[[(3,5,7-trimethyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
Homo sapiens
pH 7.4, 37°C
0.0000281
4-[[(1r,4r)-4-[[(3,5,7-trimethyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
Rattus norvegicus
pH 7.4, 37°C
0.0000345
4-[[(1r,4r)-4-[[(3,5,7-trimethyladamantan-1-yl)carbamoyl]amino]cyclohexyl]oxy]benzoic acid
Mus musculus
pH 7.4, 37°C
0.03391
5,7-dihydroxy-2-(2-hydroxy-6-methoxyphenyl)-4H-1-benzopyran-4-one
Homo sapiens
pH not specified in the publication, 37°C
0.08008
5,7-dihydroxy-2-(2-hydroxy-6-methoxyphenyl)-4H-1-benzopyran-4-one
Homo sapiens
pH not specified in the publication, 37°C
0.000005
5-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]pentanoic acid
Homo sapiens
-
0.00012
5-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]pentanoic acid
Rattus norvegicus
-
0.000008
6'-(methylsulfonyl)-N-(2-phenylcyclopropyl)-1H,4'H-spiro[azepane-4,3'-chromene]-1-carboxamide
Homo sapiens
-
0.000011
6'-(methylsulfonyl)-N-(2-phenylcyclopropyl)-1H,4'H-spiro[azepane-4,3'-chromene]-1-carboxamide
Homo sapiens
-
0.00002
6'-(methylsulfonyl)-N-(2-phenylcyclopropyl)-1H,4'H-spiro[azepane-4,3'-chromene]-1-carboxamide
Rattus norvegicus
-
0.000049
6'-(methylsulfonyl)-N-(2-phenylcyclopropyl)-1H,4'H-spiro[azepane-4,3'-chromene]-1-carboxamide
Rattus norvegicus
-
0.000004
6-(1-methyl-1H-pyrazol-5-yl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Homo sapiens
-
0.000021
6-(1-methyl-1H-pyrazol-5-yl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Rattus norvegicus
-
0.000003
6-(methylsulfonyl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Homo sapiens
-
0.000004
6-(methylsulfonyl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Homo sapiens
-
0.000011
6-(methylsulfonyl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Homo sapiens
-
0.000012
6-(methylsulfonyl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Rattus norvegicus
-
0.000023
6-(methylsulfonyl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Rattus norvegicus
-
0.000029
6-(methylsulfonyl)-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Rattus norvegicus
-
0.00043
6-amino-N-(2,4-dichlorobenzyl)pyridine-3-carboxamide
Rattus norvegicus
-
0.00052
6-amino-N-(2,4-dichlorobenzyl)pyridine-3-carboxamide
Homo sapiens
-
0.0000085
6-amino-N-(3,3-diphenylpropyl)pyridine-3-carboxamide
Rattus norvegicus
-
0.0000091
6-amino-N-(3,3-diphenylpropyl)pyridine-3-carboxamide
Homo sapiens
-
0.000003
6-fluoro-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Homo sapiens
-
0.000018
6-fluoro-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Rattus norvegicus
-
0.000003
6-[(1-methyl-1H-pyrazol-5-yl)amino]-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Homo sapiens
-
0.000013
6-[(1-methyl-1H-pyrazol-5-yl)amino]-4-oxo-N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Rattus norvegicus
-
0.000004
7-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
Homo sapiens
-
0.000004
7-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-1,2-benzoxazol-3-amine
Oryctolagus cuniculus
-
pH 7.0, 30°C
0.000002
APAU
Mesocricetus auratus
-
pH 7.5, 30°C
0.000006
APAU
Rattus norvegicus
-
pH 7.5, 30°C
0.000009
APAU
Mus musculus
-
pH 7.5, 30°C
0.000015
APAU
Homo sapiens
pH 7.4, 30°C
0.00045
APAU
Felis catus
-
pH 7.5, 30°C
0.0005
APAU
Canis lupus
-
pH 7.5, 30°C
0.000003
AUDA
Homo sapiens
pH 7.4, 30°C
0.000003
AUDA
Felis catus
-
pH 7.5, 30°C
0.000003
AUDA
Canis lupus
-
pH 7.5, 30°C
0.000005
AUDA
Mesocricetus auratus
-
pH 7.5, 30°C
0.00001
AUDA
Mus musculus
-
pH 7.5, 30°C
0.000011
AUDA
Rattus norvegicus
-
pH 7.5, 30°C
0.0000009
cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
Homo sapiens
-
in bis-Tris/HCl buffer, pH 7.0, at 25°C
0.000004
cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
Mus musculus
-
in bis-Tris/HCl buffer, pH 7.0, at 25°C
0.000007
cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
Rattus norvegicus
-
in bis-Tris/HCl buffer, pH 7.0, at 25°C
0.14
glycidyl 4-nitrobenzoate
Mus musculus
-
IC50 for the S-enantiomer is 0.14 mM
0.514
glycidyl 4-nitrobenzoate
Mus musculus
-
IC50 for the R-enantiomer 0.514 mM
0.000001
methyl 3-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]propanoate
Homo sapiens
below
0.000003
methyl 3-[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]propanoate
Rattus norvegicus
-
0.0000016
N,N'-bis(3,5,7-trimethyladamantan-1-yl)urea
Homo sapiens
pH 7.4, 37°C
0.0000253
N,N'-bis(3,5,7-trimethyladamantan-1-yl)urea
Rattus norvegicus
pH 7.4, 37°C
0.0000662
N,N'-bis(3,5,7-trimethyladamantan-1-yl)urea
Mus musculus
pH 7.4, 37°C
0.0000006
N,N'-bis(3-chloroadamantan-1-yl)urea
Homo sapiens
pH 7.4, 37°C
0.0000019
N,N'-bis(3-chloroadamantan-1-yl)urea
Rattus norvegicus
pH 7.4, 37°C
0.0000021
N,N'-bis(3-chloroadamantan-1-yl)urea
Mus musculus
pH 7.4, 37°C
0.0000031
N,N'-bis(3-methyladamantan-1-yl)urea
Rattus norvegicus
pH 7.4, 37°C
0.0000055
N,N'-bis(3-methyladamantan-1-yl)urea
Mus musculus
pH 7.4, 37°C
0.0000006
N,N'-octane-1,8-diylbis[N'-[(adamantan-1-yl)methyl]urea]
Homo sapiens
pH 7.4, 37°C
0.0000007
N,N'-octane-1,8-diylbis[N'-[(adamantan-1-yl)methyl]urea]
Homo sapiens
pH 7.4, 37°C
0.000059
N-(1,2-benzoxazol-3-yl)-3-methyl-3-phenylpiperidine-1-carboxamide
Homo sapiens
-
0.000307
N-(1,2-benzoxazol-3-yl)-3-methyl-3-phenylpiperidine-1-carboxamide
Rattus norvegicus
-
0.000006
N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
Rattus norvegicus
-
in bis-Tris/HCl buffer, pH 7.0, at 25°C
0.000007
N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
Homo sapiens
-
in bis-Tris/HCl buffer, pH 7.0, at 25°C
0.000009
N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
Mus musculus
-
in bis-Tris/HCl buffer, pH 7.0, at 25°C
0.003
N-(2,2-diphenyl-ethyl)-nicotinamide
Homo sapiens
-
0.003
N-(2,2-diphenyl-ethyl)-nicotinamide
Rattus norvegicus
-
0.000005
N-(2,3-dihydro-1H-inden-1-yl)-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Homo sapiens
-
0.000035
N-(2,3-dihydro-1H-inden-1-yl)-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Rattus norvegicus
-
0.000006
N-(2,4-dichlorobenzyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
Rattus norvegicus
-
0.000016
N-(2,4-dichlorobenzyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
Homo sapiens
-
0.000001
N-(2,4-dichlorobenzyl)-3-methyl-3-phenylpiperidine-1-carboxamide
Homo sapiens
below
0.000003
N-(2,4-dichlorobenzyl)-3-methyl-3-phenylpiperidine-1-carboxamide
Rattus norvegicus
-
0.0000066
N-(2,4-dichlorobenzyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
Homo sapiens
-
0.0000073
N-(2,4-dichlorobenzyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
Rattus norvegicus
-
0.00033
N-(2,4-dichlorobenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
Rattus norvegicus
-
0.0004
N-(2,4-dichlorobenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
Homo sapiens
-
0.0005
N-(2,4-dichlorobenzyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
Rattus norvegicus
-
0.0015
N-(2,4-dichlorobenzyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
Homo sapiens
-
0.000008
N-(2-chloro-4-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Rattus norvegicus
-
0.000014
N-(2-chloro-4-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Homo sapiens
-
0.000021
N-(2-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Homo sapiens
-
0.000022
N-(2-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Rattus norvegicus
-
0.000001
N-(2-methoxybenzyl)-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0016
N-(2-methoxybenzyl)-1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]piperidine-4-carboxamide
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000005
N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide
Homo sapiens
-
0.000021
N-(2-phenylcyclopropyl)-3',4'-dihydro-1H-spiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxamide
Rattus norvegicus
-
0.000004
N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Homo sapiens
-
0.000011
N-(2-phenylcyclopropyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamide
Rattus norvegicus
-
0.000031
N-(3,3-diphenyl-propyl)-2-pyridine-3-ylacetamide
Homo sapiens
-
0.00015
N-(3,3-diphenyl-propyl)-2-pyridine-3-ylacetamide
Rattus norvegicus
-
0.0000048
N-(3,3-diphenyl-propyl)-isonicotinamide
Rattus norvegicus
-
0.0000079
N-(3,3-diphenyl-propyl)-isonicotinamide
Homo sapiens
-
0.0000048
N-(3,3-diphenyl-propyl)-nicotinamide
Rattus norvegicus
-
0.000007
N-(3,3-diphenyl-propyl)-nicotinamide
Homo sapiens
-
0.0000026
N-(3,3-diphenylpropyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
Homo sapiens
-
0.000004
N-(3,3-diphenylpropyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
Rattus norvegicus
-
0.0000054
N-(3,3-diphenylpropyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
Homo sapiens
-
0.0000078
N-(3,3-diphenylpropyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
Rattus norvegicus
-
0.0000081
N-(3,3-diphenylpropyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
Homo sapiens
-
0.00001
N-(3,3-diphenylpropyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
Rattus norvegicus
-
0.000009
N-(3,3-diphenylpropyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
Rattus norvegicus
-
0.000018
N-(3,3-diphenylpropyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
Homo sapiens
-
0.0000065
N-(3,5,7-trimethyladamantan-1-yl)-4-([[(3,5,7-trimethyladamantan-1-yl)carbamoyl]amino]methyl)piperidine-1-carboxamide
Homo sapiens
pH 7.4, 37°C
0.0000249
N-(3,5,7-trimethyladamantan-1-yl)-4-([[(3,5,7-trimethyladamantan-1-yl)carbamoyl]amino]methyl)piperidine-1-carboxamide
Rattus norvegicus
pH 7.4, 37°C
0.000436
N-(3,5,7-trimethyladamantan-1-yl)-4-([[(3,5,7-trimethyladamantan-1-yl)carbamoyl]amino]methyl)piperidine-1-carboxamide
Mus musculus
pH 7.4, 37°C
0.0000018
N-(3,5-dimethyladamantan-1-yl)-N'-(1-propanoylpiperidin-4-yl)urea
Rattus norvegicus
pH 7.4, 37°C
0.0000033
N-(3,5-dimethyladamantan-1-yl)-N'-(1-propanoylpiperidin-4-yl)urea
Homo sapiens
pH 7.4, 37°C
0.0000052
N-(3,5-dimethyladamantan-1-yl)-N'-(1-propanoylpiperidin-4-yl)urea
Mus musculus
pH 7.4, 37°C
0.0000971
N-(3,5-dimethyladamantan-1-yl)-N'-(3,5,7-trimethyladamantan-1-yl)urea
Rattus norvegicus
pH 7.4, 37°C
0.00016
N-(3,5-dimethyladamantan-1-yl)-N'-(3,5,7-trimethyladamantan-1-yl)urea
Homo sapiens
pH 7.4, 37°C
0.011376
N-(3,5-dimethyladamantan-1-yl)-N'-(3,5,7-trimethyladamantan-1-yl)urea
Mus musculus
pH 7.4, 37°C
0.0000038
N-(3-ethyladamantan-1-yl)-N'-(1-propanoylpiperidin-4-yl)urea
Homo sapiens
pH 7.4, 37°C
0.0002686
N-(3-ethyladamantan-1-yl)-N'-(1-propanoylpiperidin-4-yl)urea
Homo sapiens
pH 7.4, 37°C
0.00007
N-(3-phenyl-propyl)-nicotinamide
Rattus norvegicus
-
0.0007
N-(3-phenyl-propyl)-nicotinamide
Homo sapiens
-
0.000026
N-(4,4-diphenyl-butyl)-nicotinamide
Rattus norvegicus
-
0.00012
N-(4,4-diphenyl-butyl)-nicotinamide
Homo sapiens
-
0.000007
N-(4-bromo-2-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Rattus norvegicus
-
0.000012
N-(4-bromo-2-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Homo sapiens
-
0.000007
N-(4-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Rattus norvegicus
-
0.000077
N-(4-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Homo sapiens
-
0.000003
N-(4-chlorophenyl)-3-(2-cyanoethyl)-3-phenylpiperidine-1-carboxamide
Homo sapiens
-
0.000016
N-(4-chlorophenyl)-3-(2-cyanoethyl)-3-phenylpiperidine-1-carboxamide
Rattus norvegicus
-
0.000001
N-(4-chlorophenyl)-3-(2-hydroxyethyl)-3-phenylpiperidine-1-carboxamide
Homo sapiens
-
0.000015
N-(4-chlorophenyl)-3-(2-hydroxyethyl)-3-phenylpiperidine-1-carboxamide
Rattus norvegicus
-
0.0000013
N-(4-chlorophenyl)-3-(3-hydroxypropyl)-3-phenylpiperidine-1-carboxamide
Homo sapiens
-
0.00001
N-(4-chlorophenyl)-3-(3-hydroxypropyl)-3-phenylpiperidine-1-carboxamide
Rattus norvegicus
-
0.000001
N-(4-chlorophenyl)-3-methyl-3-phenylpiperidine-1-carboxamide
Homo sapiens
-
0.000005
N-(4-chlorophenyl)-3-methyl-3-phenylpiperidine-1-carboxamide
Rattus norvegicus
-
0.000005
N-(4-chlorophenyl)-3-phenyl-3-[2-(1H-tetrazol-5-yl)ethyl]piperidine-1-carboxamide
Homo sapiens
-
0.000059
N-(4-chlorophenyl)-3-phenyl-3-[2-(1H-tetrazol-5-yl)ethyl]piperidine-1-carboxamide
Rattus norvegicus
-
0.000012
N-(4-chlorophenyl)-3-[2-(dimethylamino)ethyl]-3-phenylpiperidine-1-carboxamide
Homo sapiens
-
0.000119
N-(4-chlorophenyl)-3-[2-(dimethylamino)ethyl]-3-phenylpiperidine-1-carboxamide
Rattus norvegicus
-
0.0000014
N-(4-chlorophenyl)-3-[2-oxo-2-(1H-tetrazol-5-ylamino)ethyl]-3-phenylpiperidine-1-carboxamide
Homo sapiens
-
0.000034
N-(4-chlorophenyl)-3-[2-oxo-2-(1H-tetrazol-5-ylamino)ethyl]-3-phenylpiperidine-1-carboxamide
Rattus norvegicus
-
0.000003
N-(4-chlorophenyl)-3-[3-(diethylamino)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide
Homo sapiens
-
0.000031
N-(4-chlorophenyl)-3-[3-(diethylamino)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide
Rattus norvegicus
-
0.000005
N-(4-chlorophenyl)-3-[3-(methylamino)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide
Homo sapiens
-
0.000032
N-(4-chlorophenyl)-3-[3-(methylamino)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide
Rattus norvegicus
-
0.000008
N-(4-chlorophenyl)-3-[3-(morpholin-4-yl)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide
Homo sapiens
-
0.0001
N-(4-chlorophenyl)-3-[3-(morpholin-4-yl)-3-oxopropyl]-3-phenylpiperidine-1-carboxamide
Rattus norvegicus
-
0.000026
N-(4-chlorophenyl)-3-[3-oxo-3-(1H-tetrazol-5-ylamino)propyl]-3-phenylpiperidine-1-carboxamide
Rattus norvegicus
-
0.000029
N-(4-chlorophenyl)-3-[3-oxo-3-(1H-tetrazol-5-ylamino)propyl]-3-phenylpiperidine-1-carboxamide
Homo sapiens
-
0.00014
N-(4-[(3-phenyloxiran-2-yl)carbonyl]phenyl)acetamide
Homo sapiens
-
IC50 is 0.00014 mM
0.0017
N-(4-[(3-phenyloxiran-2-yl)carbonyl]phenyl)acetamide
Mus musculus
-
IC50 is 0.0017 mM
0.000006
N-(biphenyl-3-yl)-3-methyl-3-phenylpiperidine-1-carboxamide
Rattus norvegicus
-
0.000007
N-(biphenyl-3-yl)-3-methyl-3-phenylpiperidine-1-carboxamide
Homo sapiens
-
0.0000051
N-adamantan-1-yl-N'-(3,5,7-trimethyladamantan-1-yl)urea
Rattus norvegicus
pH 7.4, 37°C
0.0000061
N-adamantan-1-yl-N'-(3,5,7-trimethyladamantan-1-yl)urea
Homo sapiens
pH 7.4, 37°C
0.0001069
N-adamantan-1-yl-N'-(3,5,7-trimethyladamantan-1-yl)urea
Mus musculus
pH 7.4, 37°C
0.000005
N-adamantan-1-yl-N'-(5-hydroxypentyl)urea
Mus musculus
pH 7.4, 37°C
0.000084
N-adamantan-1-yl-N'-(5-hydroxypentyl)urea
Homo sapiens
pH 7.4, 37°C
0.0000024
N-adamantan-1-yl-N'-[(3-ethyladamantan-1-yl)methyl]urea
Homo sapiens
pH 7.4, 37°C
0.0000027
N-adamantan-1-yl-N'-[(3-ethyladamantan-1-yl)methyl]urea
Homo sapiens
pH 7.4, 37°C
0.000003
N-adamantan-1-yl-N'-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]urea
Mus musculus
pH 7.4, 37°C
0.000014
N-adamantan-1-yl-N'-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]urea
Homo sapiens
pH 7.4, 37°C
0.000006
N-adamantan-1-yl-N'-[5-[2-(2-hydroxyethoxy)ethoxy]pentyl]urea
Mus musculus
pH 7.4, 37°C
0.000015
N-adamantan-1-yl-N'-[5-[2-(2-hydroxyethoxy)ethoxy]pentyl]urea
Homo sapiens
pH 7.4, 37°C
0.00005
N-benzyl-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Rattus norvegicus
-
0.0012
N-benzyl-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Homo sapiens
-
0.0000079
N-cycloheptyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
-
0.0000079
N-cycloheptyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00069
N-cyclohexyl(dodecylamino)carboxamide
Strongylocentrotus purpuratus
crude extract from gonads
0.00091
N-cyclohexyl(dodecylamino)carboxamide
Strongylocentrotus purpuratus
recombinant SPEH1
0.05
N-cyclohexyl-N'-ethylurea
Strongylocentrotus purpuratus
crude extract from gonads
0.05
N-cyclohexyl-N'-ethylurea
Strongylocentrotus purpuratus
more than the value, recombinant SPEH1
0.0000144
N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-4-methylpiperazine-1-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.0000277
N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]-4-methylpiperazine-1-carboxamide
Rattus norvegicus
pH and temperature not specified in the publication
0.0000002
N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]piperidine-1-carboxamide
Rattus norvegicus
pH and temperature not specified in the publication
0.0000018
N-[(1s,2R,3S)-2,3-diphenylcyclopropyl]piperidine-1-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.000007
N-[(3'-chlorobiphenyl-4-yl)methyl]-3-methyl-3-phenylpiperidine-1-carboxamide
Rattus norvegicus
-
0.000014
N-[(3'-chlorobiphenyl-4-yl)methyl]-3-methyl-3-phenylpiperidine-1-carboxamide
Homo sapiens
-
0.00016
N-[2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Rattus norvegicus
-
0.00027
N-[2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Homo sapiens
-
0.0000046
N-[2-(trifluoromethoxy)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Homo sapiens
-
0.000006
N-[2-(trifluoromethoxy)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Rattus norvegicus
-
0.000021
N-[2-chloro-4-(1H-tetrazol-5-yl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Homo sapiens
-
0.00018
N-[2-chloro-4-(1H-tetrazol-5-yl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Rattus norvegicus
-
0.000014
N-[2-chloro-4-(methylsulfamoyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Homo sapiens
-
0.000019
N-[2-chloro-4-(methylsulfamoyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Rattus norvegicus
-
0.000015
N-[2-chloro-4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Homo sapiens
-
0.000016
N-[2-chloro-4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Rattus norvegicus
-
0.000005
N-[3,3-bis-(4-fluorophenyl)-propyl]-2-(2,2,2-trifluoro-ethoxy)-isonicotinamide
Homo sapiens
-
0.000006
N-[3,3-bis-(4-fluorophenyl)-propyl]-2-(2,2,2-trifluoro-ethoxy)-isonicotinamide
Rattus norvegicus
-
0.000005
N-[3,3-bis-(4-fluorophenyl)-propyl]-4-methanesulfonyl-benzamide
Homo sapiens
-
0.000007
N-[3,3-bis-(4-fluorophenyl)-propyl]-4-methanesulfonyl-benzamide
Rattus norvegicus
-
0.000005
N-[3,3-bis-(4-fluorophenyl)-propyl]-6-(2,2,2-trifluoro-ethoxy)-nicotinamide
Homo sapiens
-
0.000009
N-[3,3-bis-(4-fluorophenyl)-propyl]-6-(2,2,2-trifluoro-ethoxy)-nicotinamide
Rattus norvegicus
-
0.000005
N-[3,3-bis-(4-fluorophenyl)-propyl]-6-hydroxy-nicotinamide
Homo sapiens
-
0.000007
N-[3,3-bis-(4-fluorophenyl)-propyl]-6-hydroxy-nicotinamide
Rattus norvegicus
-
0.0000051
N-[3,3-bis-(4-fluorophenyl)-propyl]-benzamide
Homo sapiens
-
0.0000076
N-[3,3-bis-(4-fluorophenyl)-propyl]-benzamide
Rattus norvegicus
-
0.0000072
N-[3,3-bis-(4-fluorophenyl)-propyl]-nicotinamide
Rattus norvegicus
-
0.000008
N-[3,3-bis-(4-fluorophenyl)-propyl]-nicotinamide
Homo sapiens
-
0.000007
N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-4-methanesulfonyl-benzamide
Homo sapiens
-
0.000008
N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-4-methanesulfonyl-benzamide
Rattus norvegicus
-
0.000004
N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-(2,2,2-trifluoro-ethoxy)-nicotinamide
Homo sapiens
-
0.000006
N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-6-(2,2,2-trifluoro-ethoxy)-nicotinamide
Rattus norvegicus
-
0.000008
N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-nicotinamide
Homo sapiens
-
0.000014
N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-nicotinamide
Rattus norvegicus
-
0.000001
N-[3-[2-(4-chlorophenyl)ethyl]benzyl]-3-methyl-3-phenylpiperidine-1-carboxamide
Homo sapiens
-
0.000005
N-[3-[2-(4-chlorophenyl)ethyl]benzyl]-3-methyl-3-phenylpiperidine-1-carboxamide
Rattus norvegicus
-
0.000006
N-[4-(1H-indol-5-yl)benzyl]-3-methyl-3-phenylpiperidine-1-carboxamide
Rattus norvegicus
-
0.000007
N-[4-(1H-indol-5-yl)benzyl]-3-methyl-3-phenylpiperidine-1-carboxamide
Homo sapiens
-
0.00022
N-[4-(3-benzoyloxiran-2-yl)phenyl]acetamide
Mus musculus
-
IC50 is 0.00022 mM
0.00027
N-[4-(3-benzoyloxiran-2-yl)phenyl]acetamide
Homo sapiens
-
IC50 is 0.00027 mM
0.000025
N-[4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Rattus norvegicus
-
0.00011
N-[4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Homo sapiens
-
0.000011
N-[4-chloro-2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Rattus norvegicus
-
0.000066
N-[4-chloro-2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Homo sapiens
-
0.00008
N-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-N'-(4-hydroxyadamantan-1-yl)urea
Mus musculus
pH 7.4, 37°C
0.00029
N-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-N'-(4-hydroxyadamantan-1-yl)urea
Mus musculus
pH 7.4, 37°C
0.00048
N-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-N'-(4-hydroxyadamantan-1-yl)urea
Homo sapiens
pH 7.4, 37°C
0.00087
N-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]-N'-(4-hydroxyadamantan-1-yl)urea
Homo sapiens
pH 7.4, 37°C
0.0000043
N-[[4'-(methylsulfonyl)biphenyl-4-yl]methyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Rattus norvegicus
-
0.000012
N-[[4'-(methylsulfonyl)biphenyl-4-yl]methyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
Homo sapiens
-
0.0126
phenyl(3-phenyloxiran-2-yl)methanol
Mus musculus
-
IC50 is 0.0126 mM
0.022
phenyl(3-phenyloxiran-2-yl)methanol
Homo sapiens
-
IC50 is 0.022 mM
0.0003
phenyl(3-phenyloxiran-2-yl)methanone
Homo sapiens
-
IC50 is 0.0003 mM
0.0029
phenyl(3-phenyloxiran-2-yl)methanone
Mus musculus
-
IC50 is 0.0029 mM
0.0001
pyridine-2-carboxylic acid (3,3-diphenyl-propyl)-amide
Homo sapiens
-
0.00043
pyridine-2-carboxylic acid (3,3-diphenyl-propyl)-amide
Rattus norvegicus
-
0.003
pyridine-3-sulfonic acid 3,3-(diphenylpropyl)-amide
Homo sapiens
-
0.003
pyridine-3-sulfonic acid 3,3-(diphenylpropyl)-amide
Rattus norvegicus
-
2.98
trans-1-phenylpropylene oxide
Mus musculus
-
IC50 for the R-enantiomer 2.98 mM
3.47
trans-1-phenylpropylene oxide
Mus musculus
-
IC50 for the S-enantiomer is 3.47 mM
1.52
trans-2-methyl-3-phenylglycidol
Mus musculus
-
IC50 for the S-enantiomer is 1.52 mM
2
trans-2-methyl-3-phenylglycidol
Mus musculus
-
IC50 for the R-enantiomer 2.0 mM
0.12
trans-3-(4-bromophenyl)glycidol
Mus musculus
-
IC50 for the S-enantiomer is 0.12 mM
0.77
trans-3-(4-bromophenyl)glycidol
Mus musculus
-
IC50 for the R-enantiomer 0.77 mM
0.013
trans-3-(4-nitrophenyl)glycidol
Mus musculus
-
IC50 for the S-enantiomer is 0.013 mM
4.24
trans-3-(4-nitrophenyl)glycidol
Mus musculus
-
IC50 for the R-enantiomer 4.24 mM
0.232
trans-3-(4-nitrophenyl)glycidyl acetate
Mus musculus
-
IC50 for the S-enantiomer is 0.232 mM
0.39
trans-3-(4-nitrophenyl)glycidyl acetate
Mus musculus
-
IC50 for the R-enantiomer 0.39 mM
0.1
trans-3-(4-nitrophenyl)glycidyl benzoate
Mus musculus
-
IC50 for the R-enantiomer 0.10 mM
0.229
trans-3-(4-nitrophenyl)glycidyl benzoate
Mus musculus
-
IC50 for the S-enantiomer is 0.229 mM
0.0000013
trans-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
Homo sapiens
-
in bis-Tris/HCl buffer, pH 7.0, at 25°C
0.000008
trans-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
Mus musculus
-
in bis-Tris/HCl buffer, pH 7.0, at 25°C
0.000008
trans-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid
Rattus norvegicus
-
in bis-Tris/HCl buffer, pH 7.0, at 25°C
0.000001
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
Canis lupus
-
pH 7.5, 30°C
0.0000013
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
Homo sapiens
pH 7.4, 30°C
0.000002
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
Mesocricetus auratus
-
pH 7.5, 30°C
0.000006
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
Felis catus
-
pH 7.5, 30°C
0.000008
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
Mus musculus
-
pH 7.5, 30°C
0.000008
trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid
Rattus norvegicus
-
pH 7.5, 30°C
0.000052
[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]acetic acid
Homo sapiens
-
0.000398
[1-[(4-chlorophenyl)carbamoyl]-3-phenylpiperidin-3-yl]acetic acid
Rattus norvegicus
-
0.00013
[3-(2-naphthyl)oxiran-2-yl](4-nitrophenyl)methanone
Mus musculus
-
IC50 is 0.00013 mM
0.00016
[3-(2-naphthyl)oxiran-2-yl](4-nitrophenyl)methanone
Homo sapiens
-
IC50 is 0.00016 mM
0.00051
[3-(2-naphthyl)oxiran-2-yl](phenyl)methanol
Mus musculus
-
IC50 is 0.00051 mM
0.00072
[3-(2-naphthyl)oxiran-2-yl](phenyl)methanol
Homo sapiens
-
IC50 is 0.00072 mM
0.00014
[3-(2-naphthyl)oxiran-2-yl](phenyl)methanone
Mus musculus
-
IC50 is 0.00014 mM
0.0002
[3-(2-naphthyl)oxiran-2-yl](phenyl)methanone
Homo sapiens
-
IC50 is 0.0002 mM
0.00049
[3-(2-naphthyl)oxiran-2-yl](phenyl)methanone
Mus musculus
-
IC50 is 0.00049 mM
0.00085
[3-(2-naphthyl)oxiran-2-yl](phenyl)methanone
Homo sapiens
-
IC50 is 0.00085 mM
0.0002
[3-(4-bromophenyl)oxiran-2-yl](phenyl)methanone
Homo sapiens
-
IC50 is 0.0002 mM
0.0007
[3-(4-bromophenyl)oxiran-2-yl](phenyl)methanone
Mus musculus
-
IC50 is 0.0007 mM
0.00015
[3-(4-butylphenyl)oxiran-2-yl](phenyl)methanone
Mus musculus
-
IC50 is 0.00015 mM
0.00015
[3-(4-butylphenyl)oxiran-2-yl](phenyl)methanone
Homo sapiens
-
IC50 is 0.00015 mM
0.018
[3-(4-fluorophenyl)oxiran-2-yl](phenyl)methanol
Homo sapiens
-
IC50 is 0.018 mM
0.072
[3-(4-fluorophenyl)oxiran-2-yl](phenyl)methanol
Mus musculus
-
IC50 is 0.072 mM
0.0003
[3-(4-fluorophenyl)oxiran-2-yl](phenyl)methanone
Homo sapiens
-
IC50 is 0.0003 mM
0.0013
[3-(4-fluorophenyl)oxiran-2-yl](phenyl)methanone
Mus musculus
-
IC50 is 0.0013 mM
0.00048
[3-(4-heptylphenyl)oxiran-2-yl](phenyl)methanone
Homo sapiens
-
IC50 is 0.00048 mM
0.00065
[3-(4-heptylphenyl)oxiran-2-yl](phenyl)methanone
Mus musculus
-
IC50 is 0.00065 mM
0.00047
[3-(4-isopropylphenyl)oxiran-2-yl](phenyl)methanone
Mus musculus
-
IC50 is 0.00047 mM
0.00048
[3-(4-isopropylphenyl)oxiran-2-yl](phenyl)methanone
Homo sapiens
-
IC50 is 0.00048 mM
0.00011
[3-(4-methoxyphenyl)oxiran-2-yl](phenyl)methanone
Homo sapiens
-
IC50 is 0.00011 mM
0.0002
[3-(4-methoxyphenyl)oxiran-2-yl](phenyl)methanone
Mus musculus
-
IC50 is 0.0002 mM
0.00036
[3-(4-methylphenyl)oxiran-2-yl](phenyl)methanone
Homo sapiens
-
IC50 is 0.00036 mM
0.0019
[3-(4-methylphenyl)oxiran-2-yl](phenyl)methanone
Mus musculus
-
IC50 is 0.0019 mM
0.0037
[3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanol
Mus musculus
-
IC50 is 0.0037 mM
0.028
[3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanol
Homo sapiens
-
IC50 is 0.028 mM
0.00063
[3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanone
Homo sapiens
-
IC50 is 0.00063 mM
0.0018
[3-(4-nitrophenyl)oxiran-2-yl](phenyl)methanone
Mus musculus
-
IC50 is 0.0018 mM
0.00014
[3-(4-phenoxycyclohexa-1,5-dien-1-yl)oxiran-2-yl](phenyl)methanone
Mus musculus
-
IC50 is 0.00014 mM
0.00051
[3-(4-phenoxycyclohexa-1,5-dien-1-yl)oxiran-2-yl](phenyl)methanone
Homo sapiens
-
IC50 is 0.00051 mM
0.00014
[4-(allyloxy)phenyl](3-phenyloxiran-2-yl)methanone
Homo sapiens
-
IC50 is 0.00014 mM
0.0014
[4-(allyloxy)phenyl](3-phenyloxiran-2-yl)methanone
Mus musculus
-
IC50 is 0.0014 mM
0.00011
[4-(bromomethyl)phenyl][3-(2-naphthyl)oxiran-2-yl]methanone
Mus musculus
-
IC50 is 0.00011 mM
0.00016
[4-(bromomethyl)phenyl][3-(2-naphthyl)oxiran-2-yl]methanone
Homo sapiens
-
IC50 is 0.00016 mM
0.000002
[6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl][4-(trifluoromethyl)phenyl]methanone
Homo sapiens
-
0.000019
[6-(methylsulfonyl)-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidin]-1'-yl][4-(trifluoromethyl)phenyl]methanone
Rattus norvegicus
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0.00006 - 0.5
additional information
Homo sapiens
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QSAR and classification in a seven-discriptor model of enzyme inhibition by 348 urea-like compounds, IC50 ranging from 60 nM to 0.5 mM, overview
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0.00006 - 0.5
additional information
Mus musculus
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quantitative structure-activity relationship, QSAR, and classification in a five-discriptor model of enzyme inhibition by 348 urea-like compounds, IC50 ranging from 60 nM to 0.5 mM, overview
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