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2'-deoxy-2'-fluoro-5'-deoxy-5'-(methylthio)adenosine + H2O
adenine + ?
-
F-MeSAdo, slow substrate
-
-
?
2'-deoxymethylthioadenosine + H2O
adenine + 2-deoxymethylthioribose
-
fairly good substrate
-
-
?
5'-butylthioadenosine + H2O
adenine + 5-butylthio-D-ribose
24% activity compared to 5'-methylthioadenosine
-
-
?
5'-chloroadenosine + H2O
adenine + 5-chloro-D-ribose
13% activity compared to 5'-methylthioadenosine
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
5'-ethylthioadenosine + H2O
adenine + 5-ethylthio-D-ribose
5'-iodoadenosine + H2O
adenine + 5-iodo-D-ribose
17% activity compared to 5'-methylthioadenosine
-
-
?
5'-isobutylthioadenosine + H2O
adenine + 5-isobutylthio-D-ribose
32% activity compared to 5'-methylthioadenosine
-
-
?
5'-isobutylthioadenosine + H2O
adenine + 5-isobutylthioribose
-
rate of 5'-methylthioadenosine hydrolysis taken as 100%, relative activity 52%
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
5'-methylthioadenosine + H2O
?
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
5'-n-propylthioadenosine + H2O
adenine + 5-n-propylthioribose
5'-phenylthioadenosine + H2O
adenine + 5-phenylthio-D-ribose
39% activity compared to 5'-methylthioadenosine
-
-
?
6-amino-6-deoxyfutalosine + H2O
dehypoxanthine futalosine + adenine
adenosine + H2O
adenine + D-ribose
6% activity compared to 5'-methylthioadenosine
-
-
?
S-2-aza-adenosylhomocysteine + H2O
2-azaadenine + 5-(S-L-homocysteinyl)ribose
-
rate of 5'-methylthioadenosine hydrolysis taken as 100%, relative activity 27%
-
-
?
S-adenosyl-D-homocysteine + H2O
adenine + 5-(S-D-homocysteinyl)ribose
-
rate of 5'-methylthioadenosine hydrolysis taken as 100%, relative activity 26%
-
-
?
S-adenosyl-L-homocysteine + H2O
?
S-adenosyl-L-homocysteine + H2O
adenine + 5-ribosyl-L-homocysteine
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
S-adenosylhomocysteine + ?
?
S-adenosylmethionine + H2O
adenine + hypoxanthine + methylthioribose + homoserine lactone
-
-
-
?
additional information
?
-
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
preferred substrate
-
-
ir
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
preferred substrate
-
-
ir
5'-ethylthioadenosine + H2O
adenine + 5-ethylthio-D-ribose
42% activity compared to 5'-methylthioadenosine
-
-
?
5'-ethylthioadenosine + H2O
adenine + 5-ethylthio-D-ribose
-
rate of 5'-methylthioadenosine hydrolysis taken as 100%, relative activity 118%
-
-
?
5'-ethylthioadenosine + H2O
adenine + 5-ethylthio-D-ribose
-
rate of 5'-methylthioadenosine hydrolysis taken as 100%, relative activity 118%
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
100% activity
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
137135, 171850, 171851, 171852, 171854, 171856, 171858, 171859, 667625, 669334, 678158, 715849, 716263 -
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
ir
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
ir
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
ir
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
ir
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
-
-
-
-
?
5'-methylthioadenosine + phosphate
adenine + 5-methylthio-D-ribose 1-phosphate
-
-
-
-
?
5'-n-propylthioadenosine + H2O
adenine + 5-n-propylthioribose
-
rate of 5'-methylthioadenosine hydrolysis taken as 100%, relative activity 106%
-
-
?
5'-n-propylthioadenosine + H2O
adenine + 5-n-propylthioribose
-
rate of 5'-methylthioadenosine hydrolysis taken as 100%, relative activity 106%
-
-
?
6-amino-6-deoxyfutalosine + H2O
dehypoxanthine futalosine + adenine
-
-
-
?
6-amino-6-deoxyfutalosine + H2O
dehypoxanthine futalosine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
rate of 5'-methylthioadenosine hydrolysis taken as 100%, relative activity 35%
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + 5-ribosyl-L-homocysteine
isozyme AtMTAN2 shows markedly broad substrate specificity for hydrolysis of S-adenosyl-L-homocysteine, while isozyme AtMTAN1 does not
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + 5-ribosyl-L-homocysteine
substrate of isozyme AtMTAN2, isozyme AtMTAN1 can bind but not hydrolyze S-adenosyl-L-homocysteine
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + 5-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
14% activity compared to 5'-methylthioadenosine
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
Pfs protein displays 76% activity and Bgp protein shows 84% relative activity towards S-adenosyl-L-homocysteine
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
rate of 5'-methylthioadenosine hydrolysis taken as 100%, relative activity 35%
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
rate of 5'-methylthioadenosine hydrolysis taken as 100%, relative activity 42%
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
rate of 5'-methylthioadenosine hydrolysis taken as 100%, relative activity 35%
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + S-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
the catalytic efficiency of the enzyme for S-adenosyl-L-homocysteine is only 0.004% of the value for S-methyl-5'-thioadenosine
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
42% activity compared to 5'-methylthioadenosine
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
ir
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
ir
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
ir
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
?
S-adenosylhomocysteine + ?
?
-
-
-
-
?
S-adenosylhomocysteine + ?
?
-
-
-
-
?
additional information
?
-
MTAN is dual-substrate specific and is responsible for the hydrolysis of 5'-methylthioadenosine and S-adenosylhomocysteine to adenine and their corresponding thioriboses
-
-
?
additional information
?
-
dynamics are an important factor in substrate selection in MTAN, overview. Constricted 5'-alkylthio binding site of isozymes AtMTAN1 and AtMTAN2, the isozymes are also active with S-methyl-5'-thioadenosine, EC 3.2.2.16, overview. Substrate binding induces a favourable entropic change in AtMTAN1. Usage of a xanthine oxidase-coupled spectrophotometric assay: for each molecule of adenine oxidized, two molecules of 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium chloride (INT) are reduced to formazan, a coloured product that absorbs at 470 nm
-
-
?
additional information
?
-
-
substrate specificities of isozymes, both isozymes are active with S-methyl-5'-thioadenosine, EC 3.2.2.16, overview
-
-
?
additional information
?
-
substrate specificities of isozymes, both isozymes are active with S-methyl-5'-thioadenosine, EC 3.2.2.16, overview
-
-
?
additional information
?
-
-
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase is involved in quorum sensing, recycling 5'-methylthioadenosine from the polyamine pathway via adenine phosphoribosyltransferase and recycling 5-methylthioribose to methionine
-
-
?
additional information
?
-
Three structures along the reaction coordinate of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase are solved: Asp197Asn 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/5'-methylthioadenosine complex, Glu12Gln 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/5-methylthioribose/adenine complex, and wild-type 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/glycerol complex. These structures provide insight into the conformational flexibility of the enzyme and nucleoside during catalysis
-
-
?
additional information
?
-
-
no substrate: adenosine, inosine
-
-
?
additional information
?
-
-
no substrate: adenosine, inosine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
5'-methylthioadenosine + H2O
?
S-adenosyl-L-homocysteine + H2O
?
S-adenosyl-L-homocysteine + H2O
adenine + 5-ribosyl-L-homocysteine
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
additional information
?
-
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
?
5'-methylthioadenosine + H2O
5-methylthio-D-ribose + adenine
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
5'-methylthioadenosine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
rate of 5'-methylthioadenosine hydrolysis taken as 100%, relative activity 35%
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
?
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + 5-ribosyl-L-homocysteine
isozyme AtMTAN2 shows markedly broad substrate specificity for hydrolysis of S-adenosyl-L-homocysteine, while isozyme AtMTAN1 does not
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + 5-ribosyl-L-homocysteine
substrate of isozyme AtMTAN2, isozyme AtMTAN1 can bind but not hydrolyze S-adenosyl-L-homocysteine
-
-
?
S-adenosyl-L-homocysteine + H2O
adenine + 5-ribosyl-L-homocysteine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
S-adenosyl-L-homocysteine + H2O
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
-
-
-
?
additional information
?
-
MTAN is dual-substrate specific and is responsible for the hydrolysis of 5'-methylthioadenosine and S-adenosylhomocysteine to adenine and their corresponding thioriboses
-
-
?
additional information
?
-
-
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase is involved in quorum sensing, recycling 5'-methylthioadenosine from the polyamine pathway via adenine phosphoribosyltransferase and recycling 5-methylthioribose to methionine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(+/-)-cis-1-[(9-deazaadenin-9-yl)methyl]-4-ethyl-3-hydroxypyrrolidine
-
-
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-(1H-1,2,3-triazol-4-yl)pyrrolidine
-
-
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-(penta-3-yl)pyrrolidine
-
-
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-isobutylpyrrolidine
-
-
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-phenylpyrrolidine
-
-
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-vinylpyrrolidine
-
-
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-4-ethynyl-3-hydroxypyrrolidine
-
-
(+/-)-trans-4-(1-benzyl-1H-1,2,3-triazol-4-yl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
-
(+/-)-trans-4-(cyclohexylmethyl)-1-[(9-deaza-adenin-9-yl)methyl]-3-hydroxypyrrolidine
-
-
(+/-)-trans-4-allyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
-
(+/-)-trans-4-butyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
-
(+/-)-trans-4-cyclopentyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
-
(+/-)-trans-4-cyclopropyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
-
(+/-)-trans-4-[3-(benzylthio)propyl]-1-[(9-deazaadenin-9-yl)-methyl]-3-hydroxypyrrolidine
-
-
(+/-)trans-1-[(9-deazaadenin-9-yl)methyl]-4-ethyl-3-hydroxypyrrolidine
-
-
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-(3-methylphenylthio)-D-ribitol
-
-
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-(4-methylphenylthio)-D-ribitol
-
-
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-methylthio-D-ribitol
(1S)-5-(4-chlorophenylthio)-1-(9-deaza-adenin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol
-
-
(2R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol
(2R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-[(hydroxymethyl)sulfanyl]propan-1-ol
-
-
(2R,3R)-2-([[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]methyl)-4-(methylsulfanyl)butane-1,3-diol
(2R,3R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
(2R,3S)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
(2R,3S)-4-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-3-[(methylsulfanyl)methyl]butane-1,2-diol
(2S)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-2-ol
(2S)-2-[[(1S)-1-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2-hydroxyethyl]amino]-3-(methylsulfanyl)propan-1-ol
(2S)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-[(hydroxymethyl)sulfanyl]propan-1-ol
-
-
(2S,3R)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-4-(methylsulfanyl)butane-2,3-diol
(2S,3R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
(2S,3R)-N-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-3,4-dihydroxy-2-[(methylsulfanyl)methyl]butan-1-aminium trifluoroacetate
(2S,3S)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
(3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-methylpyrrolidin-3-ol
most potent inhibitor tested, 5'-deoxyadenosine transition state analogue, dissociation constant of 640 pM. Inhibitor has a weak cell growth effect on Mycobacterium tuberculosis or Mycobacterium smegmatis but is lethal toward Helicobacter pylori
(3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(butylsulfanyl)methyl]pyrrolidin-3-ol
-
(3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(hexylsulfanyl)methyl]pyrrolidin-3-ol
dissociation constant of 87 pM, inhibitor has a weak cell growth effect on Mycobacterium tuberculosis or Mycobacterium smegmatis but is lethal toward Helicobacter pylori
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-(methylthiomethyl)pyrrolidine
-
-
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-4-ethyl-3-hydroxypyrrolidine
-
-
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]3-hydroxy-4-methylthiomethylpyrrolidine
(3R,4S)-4-(1-butylthiomethyl)-1-[(9-deaza-adenin-9-yl)methyl]-3-hydroxypyrrolidine
-
-
(3R,4S)-4-(4-chlorophenyl-thiomethyl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
potential antibiotic to interfere with the metabolic pathways involved in methylation, polyamine biosynthesis, methionine recycling, and quorum sensing pathways
(3R,4S)-4-(benzylthiomethyl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
(3R,4S)-4-butyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
-
(3R,4S)-butylthio-5'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin
-
-
(3R,4S)-ethylthio-5'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin
-
-
(3R,4S)-methylthio-5'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin
-
-
(4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(ethynylsulfanyl)methyl]pyrrolidin-3-ol
transition-state analogue, shows significant overlap in specificity with human 5'-methylthioadenosine phosphorylase MTAP
(4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[[(pent-4-yn-1-yl)sulfanyl]methyl]pyrrolidin-3-ol
transition-state analogue, best binding inhibitor tested, shows significant overlap in specificity with human 5'-methylthioadenosine phosphorylase MTAP
(5'R)-5'-deoxy-5'-methylthio-8,5'-cycloadenosine
-
competitive inhibition
(p-bromophenyl)thioadenosine
-
-
(p-fluorophenyl)thioadenosine
-
-
2',3'-didehydromethylthioadenosine
-
competitive inhibition
2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propane-1,3-diol
2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol
3'-deoxy-methylthioadenosine
-
competitive inhibition
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
5'-(2-ethylhex-1-yl)thio-DADMe-immucillin A
-
5'-(4-aminophenyl)thioadenosine
-
-
5'-(4-bromophenyl)thioadenosine
-
moderate inhibitor
5'-(4-chlorophenyl)thio-DADMe-immucillin A
-
5'-(4-chlorophenyl)thioadenosine
-
-
5'-(4-fluorophenyl)thioadenosine
-
moderate inhibitor
5'-(4-hydroxybutyl)thio-DADMe-immucillin A
-
5'-(4-iodophenyl)thioadenosine
-
-
5'-(4-nitrophenyl)thioadenosine
-
most potent inhibitor
5'-(p-nitrophenyl)thioadenosine
-
most potent inhibitor
5'-butylthio-DADMe-immucillin A
-
5'-butylthio-DADMe-ImmucillinA
-
potent MTAN inhibitor, disrupting autoinducer production in a dose-dependent manner without affecting growth. Despite having a 3fold lower affinity with purified MTAN, 5'-butylthio-DADMe-ImmucillinA inhibits cellular MTAN activity 5fold better than its methylthio- and ethylthio-counterparts, significant diffusion barrier
5'-butylthioadenosine
-
-
5'-dimethylthioadenosine
-
-
5'-ethylthio-DADMe-ImmucillinA
-
potent MTAN inhibitor, disrupting autoinducer production in a dose-dependent manner without affecting growth
5'-hexylthio-DADMe-immucillin A
most potent inhibitor
5'-isobutylthio-3-deaza-adenosine
-
poor inhibitor
5'-isobutylthioadenosine
-
-
5'-Isobutylthioinosine
-
-
5'-Isopropylthioadenosine
-
-
5'-Methylselenoadenosine
-
-
5'-methylthio-3-deaza-adenosine
-
poor inhibitor
5'-methylthio-DADMe-immucillin A
-
5'-methylthio-DADMe-ImmucillinA
-
potent MTAN inhibitor, disrupting autoinducer production in a dose-dependent manner without affecting growth
5'-methylthioadenosine
-
-
5'-n-butylthioinosine
-
-
5'-n-Propylthioadenosine
-
competitive inhibition
5'-p-aminophenylthioadenosine
-
Pfs protein shows 45% relative activity in the presence of 0.1 mM 5'-p-aminophenylthioadenosine, Bgp protein shows 20% relative activity in the presence of 0.1 mM 5'-p-aminophenylthioadenosine
5'-p-nitrophenylthioadenosine
-
-
5'-p-nitrophenythioadenosine
-
Pfs protein shows 0.6% relative activity in the presence of 0.1 mM 5'-p-aminophenylthioadenosine, Bgp protein shows 5% relative activity in the presence of 0.1 mM 5'-p-aminophenylthioadenosine
5'-phenylthioadenosine
-
moderate inhibitor
5'-propylthioadenosine
-
-
5'-purinothioadenosine
-
-
benzylthio-immucillin A
-
-
butylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
picomolar inhibitor of MTAN
carbocyclic 5'-methylthioadenosine
-
-
ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
picomolar inhibitor of MTAN
ethylthio-immucillin A
-
-
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
methylthio-DADMe-immucillin-A
-
i.e. (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol
methylthio-immucillin A
-
-
p-chlorophenylthio-immucillin A
-
-
S-8-aza-adenosyl-L-homocysteine
-
powerful inhibitor
S-8-aza-adenosylhomocysteine
-
-
S-adenosyl-L-homocysteine
-
moderate inhibitor
S-adenosyl-L-homocysteine sulfoxide
-
poor inhibitor
S-adenosylhomocysteine
-
competitive inhibition
S-N6-dimethyl-3-deaza-adenosyl-L-homocysteine
-
poor inhibitor
S-Tubercidinylhomocysteine
-
powerful inhibitor
sinefungin
-
poor inhibitor
Tris
weak inhibitor; weak inhibitor, about 20% residual activity at 250 mM
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-methylthio-D-ribitol
-
-
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-methylthio-D-ribitol
-
-
(2R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol
-
-
(2R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol
-
-
(2R,3R)-2-([[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]methyl)-4-(methylsulfanyl)butane-1,3-diol
-
-
(2R,3R)-2-([[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]methyl)-4-(methylsulfanyl)butane-1,3-diol
-
-
(2R,3R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
-
(2R,3R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
-
(2R,3S)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
-
(2R,3S)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
-
(2R,3S)-4-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-3-[(methylsulfanyl)methyl]butane-1,2-diol
-
-
(2R,3S)-4-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-3-[(methylsulfanyl)methyl]butane-1,2-diol
-
-
(2S)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-2-ol
-
-
(2S)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-2-ol
-
-
(2S)-2-[[(1S)-1-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2-hydroxyethyl]amino]-3-(methylsulfanyl)propan-1-ol
-
-
(2S)-2-[[(1S)-1-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2-hydroxyethyl]amino]-3-(methylsulfanyl)propan-1-ol
-
-
(2S,3R)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-4-(methylsulfanyl)butane-2,3-diol
-
-
(2S,3R)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-4-(methylsulfanyl)butane-2,3-diol
-
-
(2S,3R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
-
(2S,3R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
-
(2S,3R)-N-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-3,4-dihydroxy-2-[(methylsulfanyl)methyl]butan-1-aminium trifluoroacetate
-
-
(2S,3R)-N-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-3,4-dihydroxy-2-[(methylsulfanyl)methyl]butan-1-aminium trifluoroacetate
-
-
(2S,3S)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
-
(2S,3S)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
-
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]3-hydroxy-4-methylthiomethylpyrrolidine
-
-
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]3-hydroxy-4-methylthiomethylpyrrolidine
-
-
(3R,4S)-4-(benzylthiomethyl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
complete inhibition at 0.1 mM
(3R,4S)-4-(benzylthiomethyl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
-
2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propane-1,3-diol
-
-
2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propane-1,3-diol
-
-
2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol
-
-
2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol
-
-
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
-
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
-
5'-Chloroformycin
-
powerful inhibitor
5'-Chloroformycin
-
competitive inhibition
5'-ethylthioadenosine
-
competitive inhibition
5'-ethylthioadenosine
-
-
5'-Methylthioformycin
-
powerful inhibitor
5'-Methylthioformycin
-
competitive inhibition
5'-methylthiotubercidin
-
powerful inhibitor
5'-methylthiotubercidin
-
-
5'-methylthiotubercidin
-
adenine
-
-
adenine
-
recombinant MTA/SAH'ase (rMTAN)
ethylthio-immucillin-A
-
-
ethylthio-immucillin-A
-
-
Formycin A
-
complete inhibition at 0.1 mM
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
-
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
-
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
picomolar inhibitor of MTAN
methylthio-immucillin-A
-
weak
methylthio-immucillin-A
-
weak
p-tolylthio-immucillin-A
-
-
p-tolylthio-immucillin-A
-
-
phenylthio-immucillin-A
-
-
phenylthio-immucillin-A
-
-
S-formycinylhomocysteine
-
powerful inhibitor
S-formycinylhomocysteine
-
competitive inhibition
additional information
-
not inhibited by 5'-methylthioinosine, S-inosyl-L-homocysteine, S-guanosyl-L-homocysteine, S-N6-methyl-3-deaza-adenosyl-L-homocysteine, S-adenosyl-L-homocysteine dialdehyde, acyclic adenosyl-L-homocysteine, S-cytidylhomocysteine, hypoxanthine, guanine, and AMP
-
additional information
-
not inhibited by 5-methylthioribose, 5-trifluoromethylthioribose, 5-(4-iodophenyl)thioribose, adenosine, erythro-9-(2-hydroxy-3-nonyl)adenine, and inosine
-
additional information
-
the transition state structure of the enzyme predictes that transition state analogue inhibitors resembling 5'-methylthioadenosine with riboxacarbenium features in the ribosyl group and elevated pKa values in the leaving group adenine analogue would be powerful inhibitors
-
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0.0109
5'-deoxyadenosine
pH and temperature not specified in the publication
0.00031 - 5.4
5'-methylthioadenosine
0.00103
6-amino-6-deoxyfutalosine
in 50 mM potassium phosphate buffer, pH 7.0, at 25°C
0.000061 - 1.3
S-adenosyl-L-homocysteine
0.0043 - 9
S-adenosylhomocysteine
additional information
additional information
-
0.00031
5'-methylthioadenosine
-
-
0.0004
5'-methylthioadenosine
-
-
0.0004
5'-methylthioadenosine
-
-
0.00043
5'-methylthioadenosine
-
-
0.00045
5'-methylthioadenosine
-
recombinant nucleosidase
0.00053
5'-methylthioadenosine
-
native nucleosidase
0.0008
5'-methylthioadenosine
21°C, pH 7.0, wild-type enzyme
0.00083
5'-methylthioadenosine
-
-
0.00093
5'-methylthioadenosine
in 50 mM potassium phosphate buffer, pH 7.0, at 25°C
0.0014
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme M9A
0.00143
5'-methylthioadenosine
-
rMTAN-8, truncated enzyme, lacking first 8 amino acids
0.0017
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme F207A
0.00173
5'-methylthioadenosine
37°C, pH 7.0
0.0022
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme Y107F
0.0027
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme S76A
0.0029
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme S196A
0.003
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme V102A
0.003
5'-methylthioadenosine
-
at 25°C, in 100 mM HEPES buffer, pH 7.5, 50 mM KCl
0.0032
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme R193A
0.0033
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme F105A
0.0034
5'-methylthioadenosine
in 100 mM sodium phosphate buffer, pH 7.0
0.0037
5'-methylthioadenosine
pH and temperature not specified in the publication
0.0071
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme I50A
0.0087
5'-methylthioadenosine
-
-
0.022
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme F151A
0.023
5'-methylthioadenosine
-
pH 7.5, 25°C
0.034
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme M173A
0.0449
5'-methylthioadenosine
at 37°C in 100 mM HEPES, 50 mM KCl, pH 7.5
0.3
5'-methylthioadenosine
-
-
0.43
5'-methylthioadenosine
-
pH 7.5, 25°C
5.4
5'-methylthioadenosine
-
-
0.000061
S-adenosyl-L-homocysteine
wild-type, pH 7.7, temperature not specified in the publication
0.000202
S-adenosyl-L-homocysteine
mutant A113P/V153I, pH 7.7, temperature not specified in the publication
0.000262
S-adenosyl-L-homocysteine
mutant A113P, pH 7.7, temperature not specified in the publication
0.00043
S-adenosyl-L-homocysteine
mutant V153I, pH 7.7, temperature not specified in the publication
0.001
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme M9A
0.0012
S-adenosyl-L-homocysteine
-
Pfs protein, at pH 5.0
0.0013
S-adenosyl-L-homocysteine
21°C, pH 7.0, wild-type enzyme
0.0016
S-adenosyl-L-homocysteine
-
Bgp protein, at pH 5.0
0.0017
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme S196A
0.0017
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme Y107F
0.0019
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme S76A
0.0019
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme V102A
0.002
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme R193A
0.00252
S-adenosyl-L-homocysteine
recombinant enzyme, in 50 mM potassium phosphate, pH 7.0
0.0028
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme F105A
0.0037
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme I50A
0.004
S-adenosyl-L-homocysteine
-
wild type enzyme, at pH 7.0 and 37°C
0.0043
S-adenosyl-L-homocysteine
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.0053
S-adenosyl-L-homocysteine
recombinant enzyme, in 50 mM potassium phosphate, pH 7.0
0.0055
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme F207A
0.0056
S-adenosyl-L-homocysteine
-
mutant enzyme S167A, at pH 7.0 and 37°C
0.0061
S-adenosyl-L-homocysteine
-
mutant enzyme R85H, at pH 7.0 and 37°C
0.0068
S-adenosyl-L-homocysteine
-
mutant enzyme R85A, at pH 7.0 and 37°C
0.01
S-adenosyl-L-homocysteine
-
wild type enzyme, in 100 mM HEPES and 50 mM KCl buffer (pH 7.2), at 37°C
0.013
S-adenosyl-L-homocysteine
-
pH 7.5, 25°C
0.0133
S-adenosyl-L-homocysteine
-
mutant enzyme R164A, at pH 7.0 and 37°C
0.014
S-adenosyl-L-homocysteine
-
mutant enzyme H109A, in 100 mM HEPES and 50 mM KCl buffer (pH 7.2), at 37°C
0.019
S-adenosyl-L-homocysteine
-
mutant enzyme F107A, in 100 mM HEPES and 50 mM KCl buffer (pH 7.2), at 37°C
0.024
S-adenosyl-L-homocysteine
-
at 25°C, in 100 mM HEPES, pH 7.5, and 50 mM KCl
0.037
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme F151A
0.0381
S-adenosyl-L-homocysteine
-
mutant enzyme Y134A, at pH 7.0 and 37°C
0.0452
S-adenosyl-L-homocysteine
-
mutant enzyme Y134F, at pH 7.0 and 37°C
0.058
S-adenosyl-L-homocysteine
-
at pH 7.5 and 25°C
0.0631
S-adenosyl-L-homocysteine
pH and temperature not specified in the publication
0.0951
S-adenosyl-L-homocysteine
-
mutant enzyme M144A, at pH 7.0 and 37°C
0.2009
S-adenosyl-L-homocysteine
in 100 mM sodium phosphate buffer, at pH 8.0 and 37°C
0.49
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme M173A
1.3
S-adenosyl-L-homocysteine
-
pH 7.5, 25°C
0.0043
S-adenosylhomocysteine
-
-
0.024
S-adenosylhomocysteine
-
at 25°C, in 100 mM HEPES buffer, pH 7.5, 50 mM KCl
9
S-adenosylhomocysteine
-
-
additional information
additional information
-
kinetics and thermodynamics of wild-type and mutant enzyme, overview
-
additional information
additional information
kinetics and thermodynamics of wild-type and mutant enzyme, overview
-
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0.47
5'-deoxyadenosine
pH and temperature not specified in the publication
0.023 - 10.2
5'-methylthioadenosine
0.53
6-amino-6-deoxyfutalosine
in 50 mM potassium phosphate buffer, pH 7.0, at 25°C
0.00021 - 9.1
S-adenosyl-L-homocysteine
0.5
S-adenosylhomocysteine
-
at 25°C, in 100 mM HEPES buffer, pH 7.5, 50 mM KCl
0.023
5'-methylthioadenosine
pH and temperature not specified in the publication
0.13
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme F207A
0.23
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme S196A
0.25
5'-methylthioadenosine
-
pH 7.5, 25°C
0.37
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme F151A
0.63
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme M9A
0.72
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme M173A
1.3
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme S76A
1.5
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme R193A
2
5'-methylthioadenosine
in 100 mM sodium phosphate buffer, pH 7.0
2
5'-methylthioadenosine
-
at 25°C, in 100 mM HEPES buffer, pH 7.5, 50 mM KCl
2.5
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme Y107F
2.7
5'-methylthioadenosine
in 50 mM potassium phosphate buffer, pH 7.0, at 25°C
3
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme I50A
3
5'-methylthioadenosine
21°C, pH 7.0, wild-type enzyme
4
5'-methylthioadenosine
-
pH 7.5, 25°C
4.92
5'-methylthioadenosine
at 37°C in 100 mM HEPES, 50 mM KCl, pH 7.5
10.2
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme F105A
10.2
5'-methylthioadenosine
21°C, pH 7.0, mutant enzyme V102A
0.00021
S-adenosyl-L-homocysteine
-
at pH 7.5 and 25°C
0.001
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme M9A
0.0017
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme Y107F
0.0019
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme S76A
0.0019
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme V102A
0.002
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme R193A
0.0028
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme F105A
0.0037
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme I50A
0.004
S-adenosyl-L-homocysteine
pH and temperature not specified in the publication
0.0055
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme F207A
0.0079
S-adenosyl-L-homocysteine
mutant V153I, pH 7.7, temperature not specified in the publication
0.00873
S-adenosyl-L-homocysteine
recombinant enzyme, in 50 mM potassium phosphate, pH 7.0
0.14
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme F151A
0.14
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme S196A
0.15
S-adenosyl-L-homocysteine
-
mutant enzyme M144A, at pH 7.0 and 37°C
0.17
S-adenosyl-L-homocysteine
mutant A113P, pH 7.7, temperature not specified in the publication
0.18
S-adenosyl-L-homocysteine
wild-type, pH 7.7, temperature not specified in the publication
0.31
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme F207A
0.35
S-adenosyl-L-homocysteine
-
mutant enzyme Y134F, at pH 7.0 and 37°C
0.37
S-adenosyl-L-homocysteine
-
pH 7.5, 25°C
0.37
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme M9A
0.39
S-adenosyl-L-homocysteine
-
mutant enzyme Y134A, at pH 7.0 and 37°C
0.4
S-adenosyl-L-homocysteine
mutant A113P/V153I, pH 7.7, temperature not specified in the publication
0.44
S-adenosyl-L-homocysteine
-
mutant enzyme F107A, in 100 mM HEPES and 50 mM KCl buffer (pH 7.2), at 37°C
0.45
S-adenosyl-L-homocysteine
recombinant enzyme, in 50 mM potassium phosphate, pH 7.0
0.49
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme M173A
0.5
S-adenosyl-L-homocysteine
-
at 25°C, in 100 mM HEPES, pH 7.5, and 50 mM KCl
0.55
S-adenosyl-L-homocysteine
-
mutant enzyme S167A, at pH 7.0 and 37°C
0.74
S-adenosyl-L-homocysteine
-
mutant enzyme H109A, in 100 mM HEPES and 50 mM KCl buffer (pH 7.2), at 37°C
0.8
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme M173A
0.92
S-adenosyl-L-homocysteine
-
mutant enzyme R85H, at pH 7.0 and 37°C
0.93
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme S76A
0.93
S-adenosyl-L-homocysteine
-
mutant enzyme R85A, at pH 7.0 and 37°C
1.2
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme R193A
1.8
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme I50A
1.8
S-adenosyl-L-homocysteine
-
wild type enzyme, in 100 mM HEPES and 50 mM KCl buffer (pH 7.2), at 37°C
2
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme Y107F
2.1
S-adenosyl-L-homocysteine
-
pH 7.5, 25°C
2.6
S-adenosyl-L-homocysteine
21°C, pH 7.0, wild-type enzyme
4.7
S-adenosyl-L-homocysteine
-
mutant enzyme R164A, at pH 7.0 and 37°C
7.1
S-adenosyl-L-homocysteine
-
wild type enzyme, at pH 7.0 and 37°C
7.5
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme F105A
9.1
S-adenosyl-L-homocysteine
21°C, pH 7.0, mutant enzyme V102A
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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0.0018
(+/-)-cis-1-[(9-deazaadenin-9-yl)methyl]-4-ethyl-3-hydroxypyrrolidine
-
in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C
0.002
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-(1H-1,2,3-triazol-4-yl)pyrrolidine
-
in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C
0.0007
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-(penta-3-yl)pyrrolidine
-
in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C
0.000047
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-isobutylpyrrolidine
-
in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C
0.00003
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-phenylpyrrolidine
-
in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C
0.00065
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-vinylpyrrolidine
-
in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C
0.00039
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-4-ethynyl-3-hydroxypyrrolidine
-
in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C
0.000064
(+/-)-trans-4-(1-benzyl-1H-1,2,3-triazol-4-yl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C
0.000059
(+/-)-trans-4-(cyclohexylmethyl)-1-[(9-deaza-adenin-9-yl)methyl]-3-hydroxypyrrolidine
-
in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C
0.00035
(+/-)-trans-4-allyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C
0.000009
(+/-)-trans-4-butyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C
0.000013
(+/-)-trans-4-cyclopentyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C
0.000063
(+/-)-trans-4-cyclopropyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C
0.000054
(+/-)-trans-4-[3-(benzylthio)propyl]-1-[(9-deazaadenin-9-yl)-methyl]-3-hydroxypyrrolidine
-
in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C
0.00084
(+/-)trans-1-[(9-deazaadenin-9-yl)methyl]-4-ethyl-3-hydroxypyrrolidine
-
in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C
0.000000009 - 0.000000015
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-(3-methylphenylthio)-D-ribitol
0.000000008 - 0.000000018
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-(4-methylphenylthio)-D-ribitol
0.00000008 - 0.00000036
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-methylthio-D-ribitol
0.000000002 - 0.000000006
(1S)-5-(4-chlorophenylthio)-1-(9-deaza-adenin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol
0.0000008 - 0.0000017
(2R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol
0.00000023
(2R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-[(hydroxymethyl)sulfanyl]propan-1-ol
-
pH and temperature not specified in the publication
0.000132 - 0.000401
(2R,3R)-2-([[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]methyl)-4-(methylsulfanyl)butane-1,3-diol
0.00001
(2R,3R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
0.0000008 - 0.0000009
(2R,3S)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
0.000061 - 0.0023
(2R,3S)-4-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-3-[(methylsulfanyl)methyl]butane-1,2-diol
0.000036 - 0.00004
(2S)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-2-ol
0.000047 - 0.00172
(2S)-2-[[(1S)-1-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2-hydroxyethyl]amino]-3-(methylsulfanyl)propan-1-ol
0.0000011
(2S)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-[(hydroxymethyl)sulfanyl]propan-1-ol
-
pH and temperature not specified in the publication
0.000085 - 0.000202
(2S,3R)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-4-(methylsulfanyl)butane-2,3-diol
0.0000039 - 0.000006
(2S,3R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
0.000005 - 0.000009
(2S,3R)-N-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-3,4-dihydroxy-2-[(methylsulfanyl)methyl]butan-1-aminium trifluoroacetate
0.0000018 - 0.0000021
(2S,3S)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
0.00000064
(3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-methylpyrrolidin-3-ol
pH 7.4, 25°C
0.000000002 - 0.000000048
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-(methylthiomethyl)pyrrolidine
0.00031
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-4-ethyl-3-hydroxypyrrolidine
-
in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C
0.000000002 - 0.00000014
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]3-hydroxy-4-methylthiomethylpyrrolidine
0.0000000003
(3R,4S)-4-(1-butylthiomethyl)-1-[(9-deaza-adenin-9-yl)methyl]-3-hydroxypyrrolidine
-
pH and temperature not specified in the publication
0.000000000047 - 0.000000026
(3R,4S)-4-(4-chlorophenyl-thiomethyl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
0.00000000046 - 0.0000034
(3R,4S)-4-(benzylthiomethyl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
0.0000034
(3R,4S)-4-butyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C
0.000004 - 0.0000058
2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propane-1,3-diol
0.00000036 - 0.0000012
2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol
0.00000036
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
0.000000099
5'-(2-ethylhex-1-yl)thio-DADMe-immucillin A
pH and temperature not specified in the publication
0.000000258
5'-(4-chlorophenyl)thio-DADMe-immucillin A
pH and temperature not specified in the publication
0.000000606
5'-(4-hydroxybutyl)thio-DADMe-immucillin A
pH and temperature not specified in the publication
0.00017
5'-(4-iodophenyl)thioadenosine
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.00002
5'-(4-nitrophenyl)thioadenosine
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.0000013
5'-butylthio-DADMe-immucillin A
pH and temperature not specified in the publication
0.000000208
5'-butylthio-DADMe-ImmucillinA
-
in 50 mM phosphate buffer, pH 7.9, 10 mM KCl, at 25°C
0.000322
5'-Chloroformycin
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.00000007
5'-ethylthio-DADMe-ImmucillinA
-
in 50 mM phosphate buffer, pH 7.9, 10 mM KCl, at 25°C
0.000000087
5'-hexylthio-DADMe-immucillin A
pH and temperature not specified in the publication
0.0000015
5'-methylthio-DADMe-immucillin A
pH and temperature not specified in the publication
0.000000073
5'-methylthio-DADMe-ImmucillinA
-
in 50 mM phosphate buffer, pH 7.9, 10 mM KCl, at 25°C
0.000027
5'-Methylthioformycin
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.00075 - 0.0041
5'-methylthiotubercidin
0.000077 - 0.000116
5'-p-aminophenylthioadenosine
0.000587 - 0.000698
5'-p-nitrophenylthioadenosine
0.3
adenine
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.000000208
butylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
at 25°C, in 50 mM phosphate buffer, pH 7.9, and 10 mM KCl
0.00000007
ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
at 25°C, in 50 mM phosphate buffer, pH 7.9, and 10 mM KCl
0.00004
ethylthio-immucillin-A
0.00105 - 0.01
Formycin A
0.000000073 - 0.000024
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
0.001
methylthio-immucillin-A
0.00006
p-tolylthio-immucillin-A
0.000335
phenylthio-immucillin-A
0.000928
S-8-aza-adenosyl-L-homocysteine
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.0024
S-adenosyl-L-homocysteine
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.0000097
S-formycinylhomocysteine
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.0019
S-Tubercidinylhomocysteine
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
25.24
Tris
at 37°C, pH 7.5
0.000000009
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-(3-methylphenylthio)-D-ribitol
-
25°C, pH 7.0,dissociation constant for the equilibrium complex of enzyme-inhibitor following slow-onset inhibition
0.000000015
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-(3-methylphenylthio)-D-ribitol
-
25°C, pH 7.0, dissociation constant for the equilibrium between enzyme and inhibitor before slow-onset inhibition
0.000000008
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-(4-methylphenylthio)-D-ribitol
-
25°C, pH 7.0, dissociation constant for the equilibrium between enzyme and inhibitor before slow-onset inhibition
0.000000018
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-(4-methylphenylthio)-D-ribitol
-
25°C, pH 7.0, dissociation constant for the equilibrium between enzyme and inhibitor before slow-onset inhibition
0.00000008
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-methylthio-D-ribitol
-
pH and temperature not specified in the publication
0.00000036
(1S)-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-5-methylthio-D-ribitol
-
pH and temperature not specified in the publication
0.000000002
(1S)-5-(4-chlorophenylthio)-1-(9-deaza-adenin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol
-
25°C, pH 7.0,dissociation constant for the equilibrium complex of enzyme-inhibitor following slow-onset inhibition
0.000000006
(1S)-5-(4-chlorophenylthio)-1-(9-deaza-adenin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol
-
25°C, pH 7.0, dissociation constant for the equilibrium between enzyme and inhibitor before slow-onset inhibition
0.0000008
(2R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol
-
pH and temperature not specified in the publication
0.0000017
(2R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol
-
pH and temperature not specified in the publication
0.000132
(2R,3R)-2-([[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]methyl)-4-(methylsulfanyl)butane-1,3-diol
-
pH and temperature not specified in the publication
0.000401
(2R,3R)-2-([[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]methyl)-4-(methylsulfanyl)butane-1,3-diol
-
pH and temperature not specified in the publication
0.00001
(2R,3R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
pH and temperature not specified in the publication
0.00001
(2R,3R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
pH and temperature not specified in the publication
0.0000008
(2R,3S)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
pH and temperature not specified in the publication
0.0000009
(2R,3S)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
pH and temperature not specified in the publication
0.000061
(2R,3S)-4-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-3-[(methylsulfanyl)methyl]butane-1,2-diol
-
pH and temperature not specified in the publication
0.0023
(2R,3S)-4-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-3-[(methylsulfanyl)methyl]butane-1,2-diol
-
pH and temperature not specified in the publication
0.000036
(2S)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-2-ol
-
pH and temperature not specified in the publication
0.00004
(2S)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-2-ol
-
pH and temperature not specified in the publication
0.000047
(2S)-2-[[(1S)-1-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2-hydroxyethyl]amino]-3-(methylsulfanyl)propan-1-ol
-
pH and temperature not specified in the publication
0.00172
(2S)-2-[[(1S)-1-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-2-hydroxyethyl]amino]-3-(methylsulfanyl)propan-1-ol
-
pH and temperature not specified in the publication
0.000085
(2S,3R)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-4-(methylsulfanyl)butane-2,3-diol
-
pH and temperature not specified in the publication
0.000202
(2S,3R)-1-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl](methyl)amino]-4-(methylsulfanyl)butane-2,3-diol
-
pH and temperature not specified in the publication
0.0000039
(2S,3R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
pH and temperature not specified in the publication
0.000006
(2S,3R)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
pH and temperature not specified in the publication
0.000005
(2S,3R)-N-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-3,4-dihydroxy-2-[(methylsulfanyl)methyl]butan-1-aminium trifluoroacetate
-
pH and temperature not specified in the publication
0.000009
(2S,3R)-N-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-3,4-dihydroxy-2-[(methylsulfanyl)methyl]butan-1-aminium trifluoroacetate
-
pH and temperature not specified in the publication
0.0000018
(2S,3S)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
pH and temperature not specified in the publication
0.0000021
(2S,3S)-2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-4-(methylsulfanyl)butane-1,3-diol
-
pH and temperature not specified in the publication
0.000000002
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-(methylthiomethyl)pyrrolidine
-
25°C, pH 7.0, dissociation constant for the equilibrium complex of enzyme-inhibitor following slow-onset inhibition
0.000000048
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-(methylthiomethyl)pyrrolidine
-
25°C, pH 7.0, dissociation constant for the equilibrium between enzyme and inhibitor before slow-onset inhibition
0.000000002
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]3-hydroxy-4-methylthiomethylpyrrolidine
-
pH and temperature not specified in the publication
0.00000014
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]3-hydroxy-4-methylthiomethylpyrrolidine
-
pH and temperature not specified in the publication
0.000000000047
(3R,4S)-4-(4-chlorophenyl-thiomethyl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
25°C, pH 7.0, dissociation constant for the equilibrium complex of enzyme-inhibitor following slow-onset inhibition
0.000000026
(3R,4S)-4-(4-chlorophenyl-thiomethyl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
25°C, pH 7.0, dissociation constant for the equilibrium between enzyme and inhibitor before slow-onset inhibition
0.00000000046
(3R,4S)-4-(benzylthiomethyl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
25°C, pH 7.0, dissociation constant for the equilibrium complex of enzyme-inhibitor following slow-onset inhibition
0.000000028
(3R,4S)-4-(benzylthiomethyl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
25°C, pH 7.0, dissociation constant for the equilibrium between enzyme and inhibitor before slow-onset inhibition
0.0000023
(3R,4S)-4-(benzylthiomethyl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
Bgp protein, at pH 5.0
0.0000034
(3R,4S)-4-(benzylthiomethyl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine
-
Pfs protein, at pH 5.0
0.000004
2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propane-1,3-diol
-
pH and temperature not specified in the publication
0.0000058
2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-2-[(methylsulfanyl)methyl]propane-1,3-diol
-
pH and temperature not specified in the publication
0.00000036
2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol
-
pH and temperature not specified in the publication
0.0000012
2-[[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol
-
pH and temperature not specified in the publication
0.00000036
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
pH 7.5, 25°C
0.00000036
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
pH 7.5, 25°C
0.00075
5'-methylthiotubercidin
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.0041
5'-methylthiotubercidin
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.000077
5'-p-aminophenylthioadenosine
-
Pfs protein, at pH 5.0
0.000116
5'-p-aminophenylthioadenosine
-
Bgp protein, at pH 5.0
0.000587
5'-p-nitrophenylthioadenosine
-
Pfs protein, at pH 5.0
0.000698
5'-p-nitrophenylthioadenosine
-
Bgp protein, at pH 5.0
0.00004
ethylthio-immucillin-A
-
pH 7.5, 25°C
0.00004
ethylthio-immucillin-A
-
pH 7.5, 25°C
0.00105
Formycin A
-
Pfs protein, at pH 5.0
0.00269
Formycin A
-
Bgp protein, at pH 5.0
0.01
Formycin A
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.000000073
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
at 25°C, in 50 mM phosphate buffer, pH 7.9, and 10 mM KCl
0.000024
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
pH 7.5, 25°C
0.000024
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
-
pH 7.5, 25°C
0.001
methylthio-immucillin-A
-
pH 7.5, 25°C
0.001
methylthio-immucillin-A
-
pH 7.5, 25°C
0.00006
p-tolylthio-immucillin-A
-
pH 7.5, 25°C
0.00006
p-tolylthio-immucillin-A
-
pH 7.5, 25°C
0.000335
phenylthio-immucillin-A
-
pH 7.5, 25°C
0.000335
phenylthio-immucillin-A
-
pH 7.5, 25°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.00037
5'-(4-aminophenyl)thioadenosine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.00085
5'-(4-bromophenyl)thioadenosine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.0002
5'-(4-chlorophenyl)thioadenosine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.0009
5'-(4-fluorophenyl)thioadenosine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.00022
5'-(4-iodophenyl)thioadenosine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.00013
5'-(4-nitrophenyl)thioadenosine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.000006
5'-butylthio-DADMe-ImmucillinA
Vibrio cholerae serotype O1
-
in 50 mM phosphate buffer, pH 7.9, 10 mM KCl, at 25°C
0.00068
5'-butylthioadenosine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.0098
5'-Chloroadenosine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.0004
5'-Chloroformycin
Escherichia coli
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.0068
5'-dimethylthioadenosine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.000031
5'-ethylthio-DADMe-ImmucillinA
Vibrio cholerae serotype O1
-
in 50 mM phosphate buffer, pH 7.9, 10 mM KCl, at 25°C
0.0009
5'-ethylthioadenosine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.013
5'-isobutylthio-3-deaza-adenosine
Escherichia coli
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.00074
5'-isobutylthioadenosine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.132
5'-Isobutylthioinosine
Escherichia coli
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.0011
5'-Isopropylthioadenosine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.0045
5'-Methylselenoadenosine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.079
5'-methylthio-3-deaza-adenosine
Escherichia coli
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.000027
5'-methylthio-DADMe-ImmucillinA
Vibrio cholerae serotype O1
-
in 50 mM phosphate buffer, pH 7.9, 10 mM KCl, at 25°C
0.001
5'-methylthioadenosine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.00006
5'-Methylthioformycin
Escherichia coli
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.03
5'-methylthioinosine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.0033 - 0.0077
5'-methylthiotubercidin
0.094
5'-n-butylthioinosine
Escherichia coli
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.00088
5'-phenylthioadenosine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.00058
5'-propylthioadenosine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.0047
5'-purinothioadenosine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.000006
butylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
Vibrio cholerae serotype O1
-
at 25°C, in 50 mM phosphate buffer, pH 7.9, and 10 mM KCl
0.027
carbocyclic 5'-methylthioadenosine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.000031
ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
Vibrio cholerae serotype O1
-
at 25°C, in 50 mM phosphate buffer, pH 7.9, and 10 mM KCl
0.057
Formycin A
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.000027
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A
Vibrio cholerae serotype O1
-
at 25°C, in 50 mM phosphate buffer, pH 7.9, and 10 mM KCl
0.0018
S-8-aza-adenosyl-L-homocysteine
Escherichia coli
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.002 - 4
S-adenosyl-L-homocysteine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.069
S-adenosyl-L-homocysteine sulfoxide
Escherichia coli
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.00002
S-formycinylhomocysteine
Escherichia coli
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.02
S-N6-dimethyl-3-deaza-adenosyl-L-homocysteine
Escherichia coli
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.0032
S-Tubercidinylhomocysteine
Escherichia coli
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.024
sinefungin
Escherichia coli
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.0033
5'-methylthiotubercidin
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
0.0077
5'-methylthiotubercidin
Escherichia coli
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.216
adenine
Escherichia coli
-
in 50 mM potassium phosphate buffer, pH 7.0, at 37°C
0.305
adenine
Escherichia coli
-
in 50 mM potassium phosphate (pH 7.0), at 37°C
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Walker, R.D.; Duerre, J.A.
S-Adenosylhomocysteine metabolism in various species
Can. J. Biochem.
53
312-319
1975
Klebsiella aerogenes, Alcaligenes faecalis, Bacillus mycoides, Citrobacter freundii, Escherichia coli, Micrococcus luteus, Staphylococcus aureus, Proteus vulgaris, Rattus rattus, Escherichia coli W-ATCC 963
brenda
Duerre, J.A.
A hydrolytic nucleosidase acting on S-adenosylhomocysteine and on 5'-methylthioadenosine
J. Biol. Chem.
237
3737-3741
1962
Escherichia coli, Escherichia coli B / ATCC 11303, Klebsiella aerogenes, Salmonella enterica subsp. enterica serovar Typhimurium
-
brenda
Ferro, A.J.; Barrett, A.; Shapiro, S.K.
Kinetic properties and the effect of substrate analogues on 5'-methylthioadenosine nucleosidase from Escherichia coli
Biochim. Biophys. Acta
438
487-494
1976
Escherichia coli, Escherichia coli B / ATCC 11303, Rattus rattus
brenda
Duerre, J.A.
S-Adenosylhomocysteine nucleosidase (Escherichia coli)
Methods Enzymol.
17
411-415
1971
Klebsiella aerogenes, Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
-
brenda
Della Ragione, F.; Porcelli, M.; Carteni-Farina, M.; Zappia, V.
Escherichia coli S-adenosylhomocysteine/5'-methylthioadenosine nucleosidasepurification, substrate specificity and mechanisms of action
Biochem. J.
232
335-341
1985
Escherichia coli
brenda
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