Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 3.2.2.28 - double-stranded uracil-DNA glycosylase

for references in articles please use BRENDA:EC3.2.2.28
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     3 Hydrolases
         3.2 Glycosylases
             3.2.2 Hydrolysing N-glycosyl compounds
                3.2.2.28 double-stranded uracil-DNA glycosylase
IUBMB Comments
No activity on DNA containing a T/G mispair or single-stranded DNA containing either a site-specific uracil or 3,N4-ethenocytosine residue , significant role for double-stranded uracil-DNA glycosylase in mutation avoidance in non-dividing E. coli . Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. Uracil-DNA glycosylase (EC 3.2.2.27) and EC 3.2.2.28 form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolysing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalysing the removal of mis-incorporated uracil from DNA.
Specify your search results
Select one or more organisms in this record: ?
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Specifically hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free uracil
Synonyms
dsudg, double-strand uracil-dna glycosylase, double-stranded uracil-dna glycosylase, g:t/u mismatch-specific dna glycosylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Specifically hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free uracil
show the reaction diagram
-
-
-
-
Select items on the left to see more content.