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chondroitin sulfate A + H2O
?
chondroitin sulfate A + H2O
oligosaccharides + ?
chondroitin sulfate C + H2O
?
chondroitin sulfate D + H2O
?
dermatan sulfate + H2O
?
-
chondroitin sulfate B, low activity
-
-
?
hyaluronan + 2 H2O
N-acetyl-beta-D-glucosamine + D-glucuronate + ?
hyaluronan + H2O
hyaluronan tetrasaccharides + hyaluronan hexasaccharides
hyaluronan is mainly degraded into hyaluronan tetrasaccharides and hyaluronan hexasaccharides. The proportion of hyaluronan tetrasaccharides and hyaluronan hexasaccharides is accurately controlled by amount of enzyme. Higher yield of hyaluronan tetrasaccharides is achieved with higher activity of the enzyme
-
-
?
hyaluronic acid + H2O
(N-acetylglucosamine)-(glucuronic acid)-(N-acetylglucosamine)-(glucuronic acid) + ?
hyaluronic acid + H2O
hyaluronic acid oligomers
additional information
?
-
chondroitin sulfate A + H2O
?
-
39% activity compared to hyaluronan
-
-
?
chondroitin sulfate A + H2O
?
-
39% activity compared to hyaluronan
-
-
?
chondroitin sulfate A + H2O
?
-
-
-
-
?
chondroitin sulfate A + H2O
?
Chrysops relictus
-
-
-
-
?
chondroitin sulfate A + H2O
?
-
-
-
-
?
chondroitin sulfate A + H2O
?
-
-
-
-
?
chondroitin sulfate A + H2O
?
Hybomitra ciureai
-
-
-
-
?
chondroitin sulfate A + H2O
?
Hybomitra muehlfeldi
-
-
-
-
?
chondroitin sulfate A + H2O
?
-
-
-
-
?
chondroitin sulfate A + H2O
?
-
-
-
-
?
chondroitin sulfate A + H2O
oligosaccharides + ?
-
-
-
-
?
chondroitin sulfate A + H2O
oligosaccharides + ?
-
-
-
-
?
chondroitin sulfate A + H2O
oligosaccharides + ?
-
low activity
-
-
?
chondroitin sulfate C + H2O
?
-
13.5% activity compared to hyaluronan
-
-
?
chondroitin sulfate C + H2O
?
-
13.5% activity compared to hyaluronan
-
-
?
chondroitin sulfate D + H2O
?
-
37.1% activity compared to hyaluronan
-
-
?
chondroitin sulfate D + H2O
?
-
37.1% activity compared to hyaluronan
-
-
?
hyaluronan + 2 H2O
N-acetyl-beta-D-glucosamine + D-glucuronate + ?
-
-
-
-
?
hyaluronan + 2 H2O
N-acetyl-beta-D-glucosamine + D-glucuronate + ?
-
-
-
-
?
hyaluronan + H2O
?
-
-
-
-
?
hyaluronan + H2O
?
-
-
-
-
?
hyaluronan + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
(N-acetylglucosamine)-(glucuronic acid)-(N-acetylglucosamine)-(glucuronic acid) + ?
-
-
-
-
?
hyaluronic acid + H2O
(N-acetylglucosamine)-(glucuronic acid)-(N-acetylglucosamine)-(glucuronic acid) + ?
-
-
-
-
?
hyaluronic acid + H2O
(N-acetylglucosamine)-(glucuronic acid)-(N-acetylglucosamine)-(glucuronic acid) + ?
-
-
-
-
?
hyaluronic acid + H2O
(N-acetylglucosamine)-(glucuronic acid)-(N-acetylglucosamine)-(glucuronic acid) + ?
-
-
-
-
?
hyaluronic acid + H2O
(N-acetylglucosamine)-(glucuronic acid)-(N-acetylglucosamine)-(glucuronic acid) + ?
-
-
-
-
?
hyaluronic acid + H2O
(N-acetylglucosamine)-(glucuronic acid)-(N-acetylglucosamine)-(glucuronic acid) + ?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
Chrysops relictus
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
Clostridium welchii
-
further hydrolysis of the end-products from bovine testicular enzyme
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
Hybomitra ciureai
-
-
-
-
?
hyaluronic acid + H2O
?
Hybomitra muehlfeldi
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
Pneumococcus sp.
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
major pathogenic factor of serological group B streptococci
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
decapsulation of mucoid strains
-
-
?
hyaluronic acid + H2O
?
-
further hydrolysis of the end-products from bovine testicular enzyme
-
-
?
hyaluronic acid + H2O
?
-
spreading factor for dermonecrosis
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
?
Theromyzon sp.
-
-
-
-
?
hyaluronic acid + H2O
?
-
-
-
-
?
hyaluronic acid + H2O
hyaluronic acid oligomers
-
-
-
?
hyaluronic acid + H2O
hyaluronic acid oligomers
-
-
-
?
hyaluronic acid + H2O
hyaluronic acid oligomers
-
-
-
?
additional information
?
-
-
no activity with dermatan sulfate, heparin sodium, heparan sulfate, sodium alginate, chitosan, chitin, sodium carboxymethyl cellulose, dextran, carboxymethyl dextran, xanthan gum, gellan gum, soluble starch, carrageenan, Konjac glucomannan, synanthrin, gumacabic powder, glycogen, or pectin
-
-
?
additional information
?
-
-
no activity with dermatan sulfate, heparin sodium, heparan sulfate, sodium alginate, chitosan, chitin, sodium carboxymethyl cellulose, dextran, carboxymethyl dextran, xanthan gum, gellan gum, soluble starch, carrageenan, Konjac glucomannan, synanthrin, gumacabic powder, glycogen, or pectin
-
-
?
additional information
?
-
-
not: chondroitin, heparan sulfate, chondroitin sulfate
-
-
?
additional information
?
-
-
not: chondroitin, heparan sulfate, chondroitin sulfate
-
-
?
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Meyer, K.; Hoffman, P.; Linker, A.
Hyaluronidase
The Enzymes, 2nd Ed (Boyer, P. D. , Lardy, H. , Myrbck, K. , eds. )
4
447-460
1960
Hirudo medicinalis
-
brenda
Linker, A.; Mayer, K.; Hoffman, P.
The production of hyaluronate oligosaccharides by leech hyaluronidase and alkali
J. Biol. Chem.
235
924-927
1960
Hirudo medicinalis
brenda
Hipkin, J.A.D.; Gacesa, G.; Olavesen, A.H.; Sawyer, R.T.
Functional arginine residues in leech hyaluronidase (orgelase)
Biochem. Soc. Trans.
17
784
1989
Hirudo medicinalis
-
brenda
Hovingh, P.; Linker, A.
Hyaluronidase activity in leeches (hirudinea)
Comp. Biochem. Physiol. B
124
319-326
1999
Erpobdella obscura, Erpobdella obscura Verrill 1872, Erpobdella punctata, Glossiphonia complanata, Glossiphonia complanata Linnaeus 1758, Haemopis marmorata, Haemopis marmorata Say 1824, Helobdella stagnalis, Helobdella stagnalis Linnaeus 1758, Hirudo medicinalis, Placobdella ornata, Placobdella ornata Verrill 1872, Placobdella picta, Placobdella picta Verrill 1872, Theromyzon sp.
brenda
Ozegowski, J.H.; Gunther, E.; Reichardt, W.
Purification and characterization of hyaluronidase from Streptococcus agalactiae
Zentralbl. Bakteriol.
280
497-506
1994
Streptococcus agalactiae
brenda
Sting, R.; Schaufuss, P.; Blobel, H.
Isolation and characterization of hyaluronidases from Streptococcus dysgalactiae, S. zooepidemicus and S. equi
Zentralbl. Bakteriol.
272
276-282
1990
Streptococcus equinus, Streptococcus equi subsp. zooepidemicus
brenda
Thurston, C.F.
Induction and catabolite repression of chondroitinase in batch and chemostat cultures of Proteus vulgaris
J. Gen. Microbiol.
80
515-522
1974
Proteus vulgaris
brenda
Meyer, K.; Rapport, M.M.
Hyaluronidases
Adv. Enzymol. Relat. Subj. Biochem.
13
199-236
1952
Clostridium welchii, Staphylococcus aureus, Pneumococcus sp., Schistosoma mansoni, Streptococcus agalactiae, Streptococcus sp., Treponema pallidum
brenda
Pecharki, D.; Petersen, F.C.; Scheie, A.A.
Role of hyaluronidase in Streptococcus intermedius biofilm
Microbiology
154
932-938
2008
Streptococcus intermedius, Streptococcus intermedius NCTC 11324
brenda
Martinez-Fleites, C.; Smith, N.L.; Turkenburg, J.P.; Black, G.W.; Taylor, E.J.
Structures of two truncated phage-tail hyaluronate lyases from Streptococcus pyogenes serotype M1
Acta Crystallogr. Sect. F
65
963-966
2009
Streptococcus pyogenes serotype M1 (Q99ZZ7), Streptococcus pyogenes serotype M1 SF370 ATCC 700294 (Q99ZZ7)
brenda
Mishra, P.; Prem Kumar, R.; Ethayathulla, A.S.; Singh, N.; Sharma, S.; Perbandt, M.; Betzel, C.; Kaur, P.; Srinivasan, A.; Bhakuni, V.; Singh, T.P.
Polysaccharide binding sites in hyaluronate lyase--crystal structures of native phage-encoded hyaluronate lyase and its complexes with ascorbic acid and lactose
FEBS J.
276
3392-3402
2009
Streptococcus pyogenes phage H10403 (Q54699)
brenda
Guo, X.; Shi, Y.; Sheng, J.; Wang, F.
A novel hyaluronidase produced by Bacillus sp. A50
PLoS ONE
9
e94156
2014
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) A50
brenda
Lv, M.; Wang, M.; Cai, W.; Hao, W.; Yuan, P.; Kang, Z.
Characterisation of separated end hyaluronan oligosaccharides from leech hyaluronidase and evaluation of angiogenesis
Carbohydr. Polym.
142
309-316
2016
Hirudo nipponia (X4Y2L4)
brenda
Volfova, V.; Tothova, V.; Volf, P.
Hyaluronidase activity in the salivary glands of tabanid flies
Insect Biochem. Mol. Biol.
73
38-46
2016
Chrysops viduatus, Chrysops relictus, Haematopota pluvialis, Hybomitra ciureai, Hybomitra muehlfeldi, Tabanus autumnalis, Tabanus maculicornis, Chrysops caecutiens
brenda
Rungsa, P.; Incamnoi, P.; Sukprasert, S.; Uawonggul, N.; Klaynongsruang, S.; Daduang, J.; Patramanon, R.; Roytrakul, S.; Daduang, S.
Cloning, structural modelling and characterization of VesT2s, a wasp venom hyaluronidase (HAase) from Vespa tropica
J. Venom. Anim. Toxins Incl. Trop. Dis.
22
28
2016
Vespa tropica
brenda