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4-methylumbelliferyl beta-D-galactoside 6-sulfate + H2O
4-methylumbelliferyl beta-D-galactoside + sulfate
-
-
-
?
4-methylumbelliferyl sulfate + H2O
4-methylumbelliferone + sulfate
-
-
-
-
?
4-methylumbelliferyl-beta-D-galactopyranoside-6-sulfate + H2O
4-methylumbelliferyl-beta-D-galactopyranoside + sulfate
-
-
-
-
?
4-methylumbelliferyl-beta-D-galactose-6-sulfate + H2O
4-methylumbelliferyl-beta-D-galactose + sulfate
-
-
-
-
?
4-methylumbelliferyl-beta-D-galactoside-6-sulfate + H2O
4-methylumbelliferyl-beta-D-galactoside + sulfate
-
-
-
?
beta-N-acetyl-D-galactosamine-6-sulfate-(1-4)-beta-D-glucuronic acid-(1-3)-N-acetyl-D-galactosaminitol 6-sulfate + H2O
sulfate + ?
-
-
-
-
?
chondroitin sulfate + H2O
chondroitin + sulfate
chondroitin-6-sulfate + H2O
chondroitin + sulfate
Gal(6-SO4)beta(1-4)-GlcAc(6-SO4)beta(1-4)-D-galactitol + H2O
sulfate + ?
-
-
-
?
galactosamine 6-sulfate + H2O
galactosamine + sulfate
-
-
-
-
?
galactose 6-sulfate + H2O
galactose + sulfate
GalNAc-4-SO4-(GlcUA-GalNAc-4-SO4)2 + H2O
sulfate + ?
-
-
-
-
?
GalNAc-4-SO4-(GlcUA-GalNAc-4-SO4)3 + H2O
sulfate + ?
-
-
-
-
?
GalNAc-4-SO4-(GlcUA-GalNAc-4-SO4)4 + H2O
sulfate + ?
-
-
-
-
?
GalNAc-4-SO4-GlcUA-GalNAc-4-SO4 + H2O
sulfate + ?
-
-
-
-
?
keratan sulfate + H2O
keratan + sulfate
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
-
in chondroitin sulfate or keratan sulfate, decreased enzymatic activity in fasting rats
-
?
N-acetylgalactosamine 6-sulfate + H2O
N-acetylgalactosamine + sulfate
N-acetylgalactosamine 6-sulfate-anhydromannitol + H2O
sulfate + ?
-
-
-
-
?
N-acetylgalactosamine 6-sulfate-beta(1-4)glucuronic acid-beta(1-3)-N-acetylgalactosaminitol 6-sulfate + H2O
sulfate + ?
-
sulfate is hydrolyzed only from the non-reducing terminal
-
-
?
O-(beta-D-6-sulfo-2-acetamido-2-deoxygalactosyl)-(1-4)-O-beta-D-glucuronosyl-(1-3)-O-beta-D-6-sulfo-2-acetamido-2-deoxy-galactitol + H2O
sulfate + ?
-
-
-
-
?
O-(beta-D-sulfogalactosyl)-(1-4)-1,5-anhydro-D-mannitol 6-sulfate + H2O
?
-
-
-
-
?
oligosaccharide substrate derived from chondroitin 6-sulfate + H2O
?
-
-
-
-
?
oligosaccharide substrates derived from keratan sulfate + H2O
?
-
-
-
-
?
sulfated tetrasaccharide + H2O
?
-
sulfated tetrasaccharide obtained by digestion of purified chondroitin 6-sulfate with resticular hyaluronidase
-
-
?
tetrasaccharide trisulfate + H2O
sulfate + N-acetylglucosamine + galactose
trisaccharide disulfate + H2O
sulfate + ?
UDP-N-acetylgalactosamine 6-sulfate + H2O
sulfate + UDP-N-acetylgalactosamine
additional information
?
-
chondroitin sulfate + H2O
chondroitin + sulfate
-
cleaves sulfate from the non-reducing N-acetylgalactosamine 6-sulfate end group
-
-
?
chondroitin sulfate + H2O
chondroitin + sulfate
-
cleaves sulfate from the non-reducing N-acetylgalactosamine 6-sulfate end group
-
-
?
chondroitin sulfate + H2O
chondroitin + sulfate
-
-
-
?
chondroitin sulfate + H2O
chondroitin + sulfate
-
-
-
?
chondroitin sulfate + H2O
chondroitin + sulfate
-
in chondroitin sulfate or keratan sulfate
-
?
chondroitin sulfate + H2O
chondroitin + sulfate
-
-
-
-
?
chondroitin sulfate + H2O
chondroitin + sulfate
-
-
-
-
?
chondroitin-6-sulfate + H2O
chondroitin + sulfate
-
-
-
-
?
chondroitin-6-sulfate + H2O
chondroitin + sulfate
-
6-sulfated tetrasaccharide from chondroitin-6-sulfate
-
?
galactose 6-sulfate + H2O
galactose + sulfate
-
about 40% of the activity with N-acetylgalactosamine 6-sulfate
-
-
?
galactose 6-sulfate + H2O
galactose + sulfate
-
about 40% of the activity with N-acetylgalactosamine 6-sulfate
-
-
?
galactose 6-sulfate + H2O
galactose + sulfate
-
-
-
-
?
galactose 6-sulfate + H2O
galactose + sulfate
-
-
-
?
galactose 6-sulfate + H2O
galactose + sulfate
-
in chondroitin sulfate or keratan sulfate
-
?
galactose 6-sulfate + H2O
galactose + sulfate
-
in chondroitin sulfate or keratan sulfate
-
?
galactose 6-sulfate + H2O
galactose + sulfate
-
in chondroitin sulfate or keratan sulfate
-
?
keratan sulfate + H2O
keratan + sulfate
-
-
-
-
?
keratan sulfate + H2O
keratan + sulfate
-
-
-
?
keratan sulfate + H2O
keratan + sulfate
-
-
-
?
N-acetylgalactosamine 6-sulfate + H2O
N-acetylgalactosamine + sulfate
-
-
-
-
?
N-acetylgalactosamine 6-sulfate + H2O
N-acetylgalactosamine + sulfate
-
-
-
-
?
N-acetylgalactosamine 6-sulfate + H2O
N-acetylgalactosamine + sulfate
-
-
-
-
?
tetrasaccharide trisulfate + H2O
sulfate + N-acetylglucosamine + galactose
-
bearing the non-reducing N-acetylglucosamine 6-sulfate
-
?
tetrasaccharide trisulfate + H2O
sulfate + N-acetylglucosamine + galactose
-
bearing the non-reducing N-acetylglucosamine 6-sulfate
-
?
trisaccharide disulfate + H2O
sulfate + ?
-
trisaccharide disulfate prepared from keratan sulfate by sequential degradation with endo-beta-galactosidase, N-acetylglucosamine-6-sulfatase and exo-beta-N-acetylglucosanminidase
-
-
?
trisaccharide disulfate + H2O
sulfate + ?
-
trisaccharide disulfate prepared from keratan sulfate by sequential degradation with endo-beta-galactosidase, N-acetylglucosamine-6-sulfatase and exo-beta-N-acetylglucosanminidase
-
-
?
UDP-N-acetylgalactosamine 6-sulfate + H2O
sulfate + UDP-N-acetylgalactosamine
-
-
-
-
?
UDP-N-acetylgalactosamine 6-sulfate + H2O
sulfate + UDP-N-acetylgalactosamine
-
-
-
-
?
additional information
?
-
-
enzyme is involved in chondroitin sulfate breakdown
-
-
?
additional information
?
-
-
concerted action of exoglycosidases and EC 3.1.6.4 in degradation of polymeric chondroitin 4-sulfate, no contribution of the enzyme to the degradation of chondroitin
-
-
?
additional information
?
-
-
does not hydrolyze sulfate from N-acetylglucosamine 6-sulfate
-
-
?
additional information
?
-
-
enzyme is involved in lysosomal degradation of the glycosaminoglycans keratan sulfate and chondroitin 6-sulfate
-
-
?
additional information
?
-
-
the enzyme catalyzes the first step of intralysosomal keratan sulfate catabolism. In Morquito A syndrome the N-acetylglucosamine 6-sulfate sulfatase deficiency causes the accumulation of keratan sulfate in tissue and results in generalized skeletal dysplasia in affected patients
-
-
?
additional information
?
-
-
enzyme deficiency causes mucopolysaccharidosis type IV, i.e. Morquio A syndrome, an autosomal recessive inborn error, due to accumulation of sulfated glycosaminoglycans in lysosomes, overview
-
-
?
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A291D
mutation associated with attenuated phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, , in wild-type, A291 has a hydrogen bond with K310
A291T
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking. In wild-type, A291 has a hydrogen bond with K310. Mutation A291T produces a new hydrogen bond with G301
C79S
-
no enzymatic activity
C79T
-
no enzymatic activity
C79Y
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking
F97V
-
10fold decrease in enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
G155R
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
G168R
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking
G290S
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking
G309R
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking
G389del
-
mutation leads to mucopolysaccharidosis IVA
G929del
-
mutation leads to mucopolysaccharidosis IVA
H142R
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking
H166Q
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking
H236D
mutation associated with an attenuated phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, residue is involved in the ligand-enzyme interaction
I113F
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
K310N
mutation associated with attenuated phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, , residue is involved in enzyme-ligand interaction
L67M
-
N-acetylgalactosamine-6-sulfatase mutation of a mucopolysaccharidosis type IV tunisian patient
M318R
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking
N204K
-
decreased enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
N289S
mutation associated with an attenuated phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, , residue is involved in the ligand-enzyme interaction
P125L
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
P151L
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
P179S
-
mutation leads to mucopolysaccharidosis IVA
P357L
-
mutation leads to mucopolysaccharidosis IVA
Q473X
-
mutation leads to mucopolysaccharidosis IVA
R295Q
-
decreased enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
R386C
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
R94C
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
R94G
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
S162F
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
S80L
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking
T312S
-
decreased enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
T763del
-
mutation leads to mucopolysaccharidosis IVA
V138A
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
C76S
active site mutation, results in inactive enzyme
G301C
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
G301C
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking
P77R
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
P77R
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking
additional information
-
polymorphism within the GALNS gene, I113F is a missense mutation
additional information
-
N-acetylgalactosamine-6-sulfatase mutations in tunisian patients cause mucopolysaccharidosis type IV, sequence determinations and mutation analysis, polymorphisms, phylogenesis, overview
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Gloessl, J.; Truppe, W.; Kresse, H.
Purification and properties of N-acetylgalactosamine 6-sulphate sulphatase from human placenta
Biochem. J.
181
37-46
1979
Homo sapiens
brenda
Nakazawa, K.; Kagabe, K.
Galactose-6-sulfatase from Actinobacillus sp. IFO-13310 and its action on sulfated oligosaccharides from keratan sulfate
Biochim. Biophys. Acta
527
391-402
1978
Actinobacillus sp., Actinobacillus sp. IFO-13310
brenda
Lim, C.T.; Horwitz, A.L.
Purification and properties of human N-acetylgalactosamine-6-sulfate sulfatase
Biochim. Biophys. Acta
657
344-355
1981
Homo sapiens
brenda
Hayashi, S.
Study on the degradation of glycosaminoglycans by canine liver lysosomal enzymes. II. The contributions of hyaluronidase, beta-glucuronidase, sulfatase, and beta-N-acetylhexosaminidase in the case of chondroitin 4-sulfate
J. Biochem.
83
149-157
1978
Canis sp.
brenda
Singh, J.; di Ferrante, N.; Niebes, P.; Tavella, D.
N-Acetylgalactosamine-6-sulfate sulfatase in man. Absence of the enzyme in Morquio disease
J. Clin. Invest.
57
1036-1040
1976
Homo sapiens
brenda
Salyers, A.A.; O'Brien, M.
Cellular location of enzymes involved in chondroitin sulfate breakdown by Bacteroides thetaiotaomicron
J. Bacteriol.
143
772-780
1980
Bacteroides thetaiotaomicron
brenda
Nakanishi, Y.; Tsuji, M.; Habuchi, H.; Suzuki, S.
Isolation of UDP-N-acetylgalactosamine-6-sulfate sulfatase from quail oviduct and its action on chondroitin sulfate
Biochem. Biophys. Res. Commun.
89
863-870
1979
Coturnix coturnix, Coturnix coturnix Japonica
brenda
Habuchi, H.; Tsuji, M.; Nakanishi, Y.; Suzuki, S.
Separation and properties of five glycosaminoglycan sulfatases from rat skin
J. Biol. Chem.
254
7570-7578
1979
Rattus norvegicus
brenda
Pshezhetsky, A.V.; Potier, M.
Association of N-acetylgalactosamine-6-sulfate sulfatase with the multienzyme lysosomal complex of beta-galactosidase, cathepsin A, and neuraminidase. Possible implication for intralysosomal catabolism of keratan sulfate
J. Biol. Chem.
271
28359-28365
1996
Homo sapiens
brenda
Bielicki, J.; Fuller, M.; Guo, X.H.; Morris, P.; Hopwood, J.J.; Anson, D.S.
Expression, purification and characterization of recombinant human N-acetylgalactosmaine-6-sulphatase
Biochem. J.
311
333-339
1995
Homo sapiens
-
brenda
Masue, M.; Sukegawa, K.; Orii, T.; Hashimoto, T.
N-Acetylgalactosamine-6-sulfate sulfatase in human placenta: purification and characteristics
J. Biochem.
110
965-970
1991
Homo sapiens
brenda
Bielicki, J.; Hopwood, J.J.
Human liver N-acetylgalactosamine 6-sulphatase. Purification and characterization
Biochem. J.
279
515-520
1991
Homo sapiens
brenda
Tomatsu, S.; Fukuda, S.; Cooper, A.; Wraith, J.E.; Yamagishi, A.; Kato, Z.; Yamada, N.; Isogai, K.; Sukegawa, K.; Suzuki, Y.; Shimozawa, N.; Kondo, N.; Orii, T.
Fifteen polymorphisms in the N-acetylgalactosamine-6-sulfate sulfatase (GALNS) gene: diagnostic implications in Morquio disease
Hum. Mutat.
Suppl. 1
S42-S46
1998
Homo sapiens
brenda
Cechowska-Pasko, M.; Wolanska, M.; Pallka, J.
Glycosaminoglycan-degrading enzymes in the skin of fasted rats
Comp. Biochem. Physiol. B
131
551-557
2002
Rattus norvegicus
brenda
Sukegawa, K.; Nakamura, H.; Kato, Z.; Tomatsu, S.; Montano, A.M.; Fukao, T.; Toietta, G.; Tortora, P.; Orii, T.; Kondo, N.
Biochemical and structural analysis of missense mutations in N-acetylgalactosamine-6-sulfate sulfatase causing mucopolysaccharidosis IVA phenotypes
Hum. Mol. Genet.
9
1283-1290
2000
Homo sapiens
brenda
Terzioglu, M.; Tokatli, A.; Coskun, T.; Emre, S.
Molecular analysis of Turkish mucopolysaccharidosis IVA (Morquio A) patients: identification of novel mutations in the N-acetylgalactosamine-6-sulfate sulfatase (GALNS) gene
Hum. Mutat.
20
477-478
2002
Homo sapiens
brenda
Tomatsu, S.; Filocamo, M.; Orii, K.O.; Sly, W.S.; Gutierrez, M.A.; Nishioka, T.; Serrato, O.P.; Di Natale, P.; Montano, A.M.; Yamaguchi, S.; Kondo, N.; Orii, T.; Noguchi, A.
Mucopolysaccharidosis IVA (Morquio A): identification of novel common mutations in the N-acetylgalactosamine-6-sulfate sulfatase (GALNS) gene in Italian patients
Hum. Mutat.
24
187-188
2004
Homo sapiens
brenda
de Assis, C.M.; Gandra, R.F.; Gambale, W.; Shimizu, M.T.; Paula, C.R.
Biosynthesis of chondroitinase and hyaluronidase by different strains of Paracoccidioides brasiliensis
J. Med. Microbiol.
52
479-481
2003
Paracoccidioides brasiliensis
brenda
Coutinho, S.D.; Paula, C.R.
Proteinase, phospholipase, hyaluronidase and chondroitin-sulphatase production by Malassezia pachydermatis
Med. Mycol.
38
73-76
2000
Malassezia pachydermatis
brenda
Laradi, S.; Tukel, T.; Khediri, S.; Shabbeer, J.; Erazo, M.; Chkioua, L.; Chaabouni, M.; Ferchichi, S.; Miled, A.; Desnick, R.J.
Mucopolysaccharidosis type IV: N-acetylgalactosamine-6-sulfatase mutations in Tunisian patients
Mol. Genet. Metab.
87
213-218
2006
Homo sapiens
brenda
Parkinson-Lawrence, E.J.; Muller, V.J.; Hopwood, J.J.; Brooks, D.A.
N-acetylgalactosamine-6-sulfatase protein detection in MPS IVA patient and unaffected control samples
Clin. Chim. Acta
377
88-91
2007
Homo sapiens (P34059), Homo sapiens
brenda
Bhattacharyya, S.; Kotlo, K.; Shukla, S.; Danziger, R.S.; Tobacman, J.K.
Distinct effects of N-acetylgalactosamine-4-sulfatase and galactose-6-sulfatase expression on chondroitin sulfates
J. Biol. Chem.
283
9523-9530
2008
Homo sapiens (P34059)
brenda
Tomatsu, S.; Vogler, C.; Montano, A.M.; Gutierrez, M.; Oikawa, H.; Dung, V.C.; Orii, T.; Noguchi, A.; Sly, W.S.
Murine model (Galns(tm(C76S)slu)) of MPS IVA with missense mutation at the active site cysteine conserved among sulfatase proteins
Mol. Genet. Metab.
91
251-258
2007
Mus musculus (Q571E4), Mus musculus
brenda
Tomatsu, S.; Montano, A.M.; Gutierrez, M.; Grubb, J.H.; Oikawa, H.; Dung, V.C.; Ohashi, A.; Nishioka, T.; Yamada, M.; Yamada, M.; Tosaka, Y.; Trandafirescu, G.G.; Orii, T.
Characterization and pharmacokinetic study of recombinant human N-acetylgalactosamine-6-sulfate sulfatase
Mol. Genet. Metab.
91
69-78
2007
Homo sapiens
brenda
Almeciga-Diaz, C.J.; Rueda-Paramo, M.A.; Espejo, A.J.; Echeverri, O.Y.; Montano, A.; Tomatsu, S.; Barrera, L.A.
Effect of elongation factor 1alpha promoter and SUMF1 over in vitro expression of N-acetylgalactosamine-6-sulfate sulfatase
Mol. Biol. Rep.
36
1863-1870
2008
Homo sapiens
brenda
Grinwis, M.E.; Sibley, C.D.; Parkins, M.D.; Eshaghurshan, C.S.; Rabin, H.R.; Surette, M.G.
Characterization of Streptococcus milleri group isolates from expectorated sputum of adult patients with cystic fibrosis
J. Clin. Microbiol.
48
395-401
2010
Streptococcus intermedius, Streptococcus constellatus, no activity in Streptococcus anginosus
brenda
Rodriguez, A.; Espejo, A.J.; Hernandez, A.; Velasquez, O.L.; Lizaraso, L.M.; Cordoba, H.A.; Sanchez, O.F.; Almeciga-Diaz, C.J.; Barrera, L.A.
Enzyme replacement therapy for MorquioA: an active recombinant N-acetylgalactosamine-6-sulfate sulfatase produced in Escherichia coli BL21
J. Ind. Microbiol. Biotechnol.
37
1193-1201
2010
Homo sapiens (P34059)
brenda
Yang, B.; Bhattacharyya, S.; Linhardt, R.; Tobacman, J.
Exposure to common food additive carrageenan leads to reduced sulfatase activity and increase in sulfated glycosaminoglycans in human epithelial cells
Biochimie
94
1309-1316
2012
Homo sapiens (P34059), Homo sapiens
brenda
Hernandez, A.; Velasquez, O.; Leonardi, F.; Soto, C.; Rodriguez, A.; Lizaraso, L.; Mosquera, A.; Bohorquez, J.; Coronado, A.; Espejo, A.; Sierra, R.; Sanchez, O.F.; Almeciga-Diaz, C.J.; Barrera, L.A.
Effect of culture conditions and signal peptide on production of human recombinant N-acetylgalactosamine-6-sulfate sulfatase in Escherichia coli BL21
J. Microbiol. Biotechnol.
23
689-698
2013
Homo sapiens (P34059), Homo sapiens
brenda
Feferman, L.; Bhattacharyya, S.; Birch, L.; Prins, G.S.; Tobacman, J.K.
Differential effects of estrogen exposure on arylsulfatase B, galactose-6-sulfatase, and steroid sulfatase in rat prostate development
J. Steroid Biochem. Mol. Biol.
143
105-114
2014
Rattus norvegicus (P50430)
brenda
Olarte-Avellaneda, S.; Rodriguez-Lopez, A.; Almeciga-Diaz, C.J.; Barrera, L.A.
Computational analysis of human N-acetylgalactosamine-6-sulfate sulfatase enzyme: an update in genotype-phenotype correlation for Morquio A
Mol. Biol. Rep.
41
7073-7088
2014
Homo sapiens (P34059), Homo sapiens
brenda
Egan, M.; Jiang, H.; OConnell Motherway, M.; Oscarson, S.; van Sinderen, D.
Glycosulfatase-encoding gene cluster in Bifidobacterium breve UCC2003
Appl. Environ. Microbiol.
82
6611-6623
2016
Bifidobacterium breve, Bifidobacterium breve UCC2003
brenda
Shams, S.; Barazandeh Tehrani, M.; Civallero, G.; Minookherad, K.; Giugliani, R.; Setoodeh, A.; Ashtiani, M.
Diagnosing mucopolysaccharidosis type IV a by the fluorometric assay of N-acetylgalactosamine-6-sulfate sulfatase activity
J. Diabetes Metab. Disord.
16
37
2017
Homo sapiens (P34059), Homo sapiens
brenda
Mashima, R.; Ohira, M.; Okuyama, T.; Tatsumi, A.
Quantification of the enzyme activities of iduronate-2-sulfatase, N-acetylgalactosamine-6-sulfatase and N-acetylgalactosamine-4-sulfatase using liquid chromatography-tandem mass spectrometry
Mol. Genet. Metab. Rep.
14
36-40
2018
Homo sapiens (P34059)
brenda
Bhattacharyya, S.; Feferman, L.; Tobacman, J.K.
Chondroitin sulfatases differentially regulate Wnt signaling in prostate stem cells through effects on SHP2, phospho-ERK1/2, and Dickkopf Wnt signaling pathway inhibitor (DKK3)
Oncotarget
8
242-260
2017
Homo sapiens (P34059), Homo sapiens
brenda
Matassini, C.; Vanni, C.; Goti, A.; Morrone, A.; Marradi, M.; Cardona, F.
Multimerization of DAB-1 onto Au GNPs affords new potent and selective N-acetylgalactosamine-6-sulfatase (GALNS) inhibitors
Org. Biomol. Chem.
16
8604-8612
2018
Homo sapiens (P34059)
brenda
Rodriguez-Lopez, A.; Almeciga-Diaz, C.J.; Sanchez, J.; Moreno, J.; Beltran, L.; Diaz, D.; Pardo, A.; Ramirez, A.M.; Espejo-Mojica, A.J.; Pimentel, L.; Barrera, L.A.
Recombinant human N-acetylgalactosamine-6-sulfate sulfatase (GALNS) produced in the methylotrophic yeast Pichia pastoris
Sci. Rep.
6
29329
2016
Homo sapiens (P34059), Homo sapiens
brenda
Reyes, L.; Cardona, C.; Pimentel, L.; Rodriguez-Lopez, A.; Almeciga-Diaz, C.
Improvement in the production of the human recombinant enzyme N-acetylgalactosamine-6-sulfatase (rhGALNS) in Escherichia coli using synthetic biology approaches
Sci. Rep.
7
5844
2017
Homo sapiens (P34059), Homo sapiens
brenda