Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(S)-3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + (S)-3-hydroxy-2-methylpropanoate
-
-
-
?
(S)-3-hydroxyisobutyryl-CoA + H2O
CoA + (S)-3-hydroxyisobutyrate
(S)-methylmalonyl-CoA + H2O
CoA + methylmalonate
-
-
-
-
?
3-hydroxy-2-methylbutyryl-CoA + H2O
CoA + 3-hydroxy-2-methylbutyrate
-
low activity
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
3-hydroxy-2-methylpropanoate + CoA
-
substrate is an intermediate in the pathway of valine catabolism, which is unique in that it produces a radily diffusible monocarboxylic acid
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
3-hydroxy-3-phenylpropionyl-CoA + H2O
3-hydroxy-3-phenylpropionate + CoA
-
-
-
?
3-hydroxyisobutyryl-CoA + H2O
CoA + 3-hydroxyisobutyrate
-
formation of an anhydride reaction intermediate, Glu164 is involved
-
?
3-hydroxypropanoyl-CoA + H2O
CoA + 3-hydroxypropanoate
3-hydroxypropionyl-CoA + H2O
CoA + 3-hydroxypropionate
-
-
-
-
ir
cinnamoyl-CoA + H2O
cinnamic acid + CoA
-
-
-
?
DL-3-hydroxybutyryl-CoA + H2O
CoA + DL-3-hydroxybutyrate
-
low activity
-
?
L-3-hydroxybutyryl-CoA + H2O
CoA + L-3-hydroxybutyrate
-
low activity
-
?
p-coumaroyl-CoA + H2O
p-coumaric acid + CoA
-
-
-
?
additional information
?
-
(S)-3-hydroxyisobutyryl-CoA + H2O
CoA + (S)-3-hydroxyisobutyrate
-
-
-
-
ir
(S)-3-hydroxyisobutyryl-CoA + H2O
CoA + (S)-3-hydroxyisobutyrate
-
-
-
ir
(S)-3-hydroxyisobutyryl-CoA + H2O
CoA + (S)-3-hydroxyisobutyrate
-
-
-
ir
(S)-3-hydroxyisobutyryl-CoA + H2O
CoA + (S)-3-hydroxyisobutyrate
-
-
-
-
ir
(S)-3-hydroxyisobutyryl-CoA + H2O
CoA + (S)-3-hydroxyisobutyrate
-
-
-
-
ir
3-hydroxy-2-methylpropanoyl-CoA + H2O
?
the enzyme is responsible for the specific hydrolysis of 3-hydroxy-2-methylpropanoyl-CoA, a saline catabolite
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
?
-
-
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
?
-
enzyme is involved in Val catabolism. The enzyme protects cells against toxic effects of methacrylyl-CoA, an intermediate in the Val pathway occuring upstream of 3-hydroxy-2-methylpropanoyl-CoA
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
(S)-3-hydroxyacids and their esters, such as (S)-3-hydroxybutyric acid, can be used as chiral building blocks for the chemical synthesis of optically active fine chemicals such as antibiotics, vitamins, perfumes, and pheromones
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
-
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
-
-
ir
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
key enzyme in valine metabolism regulating the toxic concentration of methacrylyl-coenzyme A, human liver disease decreases the enzyme activity in vivo
-
ir
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
-
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
-
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
-
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
-
-
?
3-hydroxypropanoyl-CoA + H2O
CoA + 3-hydroxypropanoate
-
-
-
?
3-hydroxypropanoyl-CoA + H2O
CoA + 3-hydroxypropanoate
-
-
-
?
3-hydroxypropanoyl-CoA + H2O
CoA + 3-hydroxypropanoate
hydrolysis of beta-hydroxypropionyl-CoA, an intermediate in a minor pathway of propionate metabolism
-
-
?
3-hydroxypropanoyl-CoA + H2O
CoA + 3-hydroxypropanoate
-
-
-
-
?
additional information
?
-
has no hydrolase activity with benzoyl-CoA
-
-
?
additional information
?
-
-
has no hydrolase activity with benzoyl-CoA
-
-
?
additional information
?
-
-
substrate specificity, overview, acetoacetyl-CoA, DL-methylmalonyl-CoA, isobutyryl-CoA, malonyl-CoA, acetyl-CoA, propionyl-CoA, and n-valeryl-CoA are poor substrates
-
?
additional information
?
-
mutations in the gene encoding 3-hydroxyisobutyryl-CoA hydrolase results in progressive infantile neurodegeneration
-
-
?
additional information
?
-
-
mutations in the gene encoding 3-hydroxyisobutyryl-CoA hydrolase results in progressive infantile neurodegeneration
-
-
?
additional information
?
-
-
enzyme production is induced in presence of Val, 2-oxoisovalerate, isobutyrate and 3-hydroxyisobutyrate. Intermediates of the Krebs cycle repress the formation of 3-hydroxyisobutyryl CoA when isobutyrate is present as the inducer. Activity is maximal at the end of the exponential phase
-
-
?
additional information
?
-
-
enzyme production is induced in presence of Val, 2-oxoisovalerate, isobutyrate and 3-hydroxyisobutyrate. Intermediates of the Krebs cycle repress the formation of 3-hydroxyisobutyryl CoA when isobutyrate is present as the inducer. Activity is maximal at the end of the exponential phase
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(S)-3-hydroxyisobutyryl-CoA + H2O
CoA + (S)-3-hydroxyisobutyrate
3-hydroxy-2-methylpropanoyl-CoA + H2O
3-hydroxy-2-methylpropanoate + CoA
-
substrate is an intermediate in the pathway of valine catabolism, which is unique in that it produces a radily diffusible monocarboxylic acid
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
3-hydroxypropanoyl-CoA + H2O
CoA + 3-hydroxypropanoate
hydrolysis of beta-hydroxypropionyl-CoA, an intermediate in a minor pathway of propionate metabolism
-
-
?
3-hydroxypropionyl-CoA + H2O
CoA + 3-hydroxypropionate
-
-
-
-
ir
additional information
?
-
(S)-3-hydroxyisobutyryl-CoA + H2O
CoA + (S)-3-hydroxyisobutyrate
-
-
-
-
ir
(S)-3-hydroxyisobutyryl-CoA + H2O
CoA + (S)-3-hydroxyisobutyrate
-
-
-
ir
(S)-3-hydroxyisobutyryl-CoA + H2O
CoA + (S)-3-hydroxyisobutyrate
-
-
-
ir
(S)-3-hydroxyisobutyryl-CoA + H2O
CoA + (S)-3-hydroxyisobutyrate
-
-
-
-
ir
(S)-3-hydroxyisobutyryl-CoA + H2O
CoA + (S)-3-hydroxyisobutyrate
-
-
-
-
ir
3-hydroxy-2-methylpropanoyl-CoA + H2O
?
the enzyme is responsible for the specific hydrolysis of 3-hydroxy-2-methylpropanoyl-CoA, a saline catabolite
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
?
-
-
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
?
-
enzyme is involved in Val catabolism. The enzyme protects cells against toxic effects of methacrylyl-CoA, an intermediate in the Val pathway occuring upstream of 3-hydroxy-2-methylpropanoyl-CoA
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
key enzyme in valine metabolism regulating the toxic concentration of methacrylyl-coenzyme A, human liver disease decreases the enzyme activity in vivo
-
ir
additional information
?
-
mutations in the gene encoding 3-hydroxyisobutyryl-CoA hydrolase results in progressive infantile neurodegeneration
-
-
?
additional information
?
-
-
mutations in the gene encoding 3-hydroxyisobutyryl-CoA hydrolase results in progressive infantile neurodegeneration
-
-
?
additional information
?
-
-
enzyme production is induced in presence of Val, 2-oxoisovalerate, isobutyrate and 3-hydroxyisobutyrate. Intermediates of the Krebs cycle repress the formation of 3-hydroxyisobutyryl CoA when isobutyrate is present as the inducer. Activity is maximal at the end of the exponential phase
-
-
?
additional information
?
-
-
enzyme production is induced in presence of Val, 2-oxoisovalerate, isobutyrate and 3-hydroxyisobutyrate. Intermediates of the Krebs cycle repress the formation of 3-hydroxyisobutyryl CoA when isobutyrate is present as the inducer. Activity is maximal at the end of the exponential phase
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3-hydroxyisobutyryl-coa hydrolase deficiency
3-Hydroxyisobutyryl-CoA Hydrolase (HIBCH) Deficiency Cases Diagnosed by Only HIBCH Gene Analysis and Novel Pathogenic Mutation.
3-hydroxyisobutyryl-coa hydrolase deficiency
3-Hydroxyisobutyryl-CoA hydrolase deficiency in an infant with developmental delay and high anion gap acidosis.
3-hydroxyisobutyryl-coa hydrolase deficiency
3-Hydroxyisobutyryl-CoA hydrolase deficiency in an Iranian child with novel HIBCH compound heterozygous mutations.
3-hydroxyisobutyryl-coa hydrolase deficiency
A movement disorder with dystonia and ataxia caused by a mutation in the HIBCH gene.
3-hydroxyisobutyryl-coa hydrolase deficiency
A phenotypically severe, biochemically "silent" case of HIBCH deficiency in a newborn diagnosed by rapid whole exome sequencing and enzymatic testing.
3-hydroxyisobutyryl-coa hydrolase deficiency
A therapeutic regimen for 3-hydroxyisobutyryl-CoA hydrolase deficiency with exercise-induced dystonia.
3-hydroxyisobutyryl-coa hydrolase deficiency
Case report and novel treatment of an autosomal recessive Leigh syndrome caused by short-chain enoyl-CoA hydratase deficiency.
3-hydroxyisobutyryl-coa hydrolase deficiency
Cinical, Metabolic, and Genetic Analysis and Follow-Up of Eight Patients With HIBCH Mutations Presenting With Leigh/Leigh-Like Syndrome.
3-hydroxyisobutyryl-coa hydrolase deficiency
Clinical and biochemical characterization of 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency that causes Leigh-like disease and ketoacidosis.
3-hydroxyisobutyryl-coa hydrolase deficiency
Delineating the neurological phenotype in children with defects in the ECHS1 or HIBCH gene.
3-hydroxyisobutyryl-coa hydrolase deficiency
ECHS1 mutations in Leigh disease: a new inborn error of metabolism affecting valine metabolism.
3-hydroxyisobutyryl-coa hydrolase deficiency
HIBCH deficiency in a patient with phenotypic characteristics of mitochondrial disorders.
3-hydroxyisobutyryl-coa hydrolase deficiency
Metabolite studies in HIBCH and ECHS1 defects: Implications for screening.
3-hydroxyisobutyryl-coa hydrolase deficiency
MRI of 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency.
3-hydroxyisobutyryl-coa hydrolase deficiency
Mutations in the gene encoding 3-hydroxyisobutyryl-CoA hydrolase results in progressive infantile neurodegeneration.
3-hydroxyisobutyryl-coa hydrolase deficiency
Paroxysmal Dyskinesias Revealing 3-Hydroxy-Isobutyryl-CoA Hydrolase (HIBCH) Deficiency.
3-hydroxyisobutyryl-coa hydrolase deficiency
Successful diagnosis of HIBCH deficiency from exome sequencing and positive retrospective analysis of newborn screening cards in two siblings presenting with Leigh's disease.
3-hydroxyisobutyryl-coa hydrolase deficiency
Syndromic progressive neurodegenerative disease of infancy caused by novel variants in HIBCH: Report of two cases in Colombia.
3-hydroxyisobutyryl-coa hydrolase deficiency
Thiamine-Responsive and Non-responsive Patients with PDHC-E1 Deficiency: A Retrospective Assessment.
3-hydroxyisobutyryl-coa hydrolase deficiency
Truncating mutations of HIBCH tend to cause severe phenotypes in cases with HIBCH deficiency: a case report and brief literature review.
3-hydroxyisobutyryl-coa hydrolase deficiency
Whole-exome sequencing identifies novel ECHS1 mutations in Leigh syndrome.
3-hydroxyisobutyryl-coa hydrolase deficiency
[Diagnosis and treatment of 3-hydroxyisobutyryl-CoA hydrolase deficiency: a case report and literature review].
Acidosis
3-Hydroxyisobutyryl-CoA hydrolase deficiency in an infant with developmental delay and high anion gap acidosis.
Ataxia
A movement disorder with dystonia and ataxia caused by a mutation in the HIBCH gene.
Ataxia
MRI of 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency.
Basal Ganglia Diseases
Clinical and biochemical characterization of 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency that causes Leigh-like disease and ketoacidosis.
Colorectal Neoplasms
Targeting HIBCH to reprogram valine metabolism for the treatment of colorectal cancer.
Dystonia
A movement disorder with dystonia and ataxia caused by a mutation in the HIBCH gene.
Dystonia
A therapeutic regimen for 3-hydroxyisobutyryl-CoA hydrolase deficiency with exercise-induced dystonia.
Dystonia
Delineating the neurological phenotype in children with defects in the ECHS1 or HIBCH gene.
Dystonia
MRI of 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency.
Hemochromatosis
Hemizygous deletion of COL3A1, COL5A2, and MSTN causes a complex phenotype with aortic dissection: a lesson for and from true haploinsufficiency.
Infections
Paroxysmal Dyskinesias Revealing 3-Hydroxy-Isobutyryl-CoA Hydrolase (HIBCH) Deficiency.
Ketosis
Clinical and biochemical characterization of 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency that causes Leigh-like disease and ketoacidosis.
Leigh Disease
Delineating the neurological phenotype in children with defects in the ECHS1 or HIBCH gene.
Leigh Disease
ECHS1 mutations in Leigh disease: a new inborn error of metabolism affecting valine metabolism.
Leigh Disease
Identification of HIBCH Gene Mutations Causing Autosomal Recessive Leigh Syndrome: A Gene Involved in Valine Metabolism.
Leigh Disease
Paroxysmal Dyskinesias Revealing 3-Hydroxy-Isobutyryl-CoA Hydrolase (HIBCH) Deficiency.
Leigh Disease
Successful diagnosis of HIBCH deficiency from exome sequencing and positive retrospective analysis of newborn screening cards in two siblings presenting with Leigh's disease.
Leigh Disease
[3-Hydroxy-isobutyryl-CoA hydrolase deficiency in a child with Leigh-like syndrome and literature review].
Liver Diseases
Human liver disease decreases methacrylyl-CoA hydratase and beta-hydroxyisobutyryl-CoA hydrolase activities in valine catabolism.
Liver Failure
The valine catabolic pathway in human liver: effect of cirrhosis on enzyme activities.
Metabolic Diseases
3-Hydroxyisobutyryl-CoA Hydrolase (HIBCH) Deficiency Cases Diagnosed by Only HIBCH Gene Analysis and Novel Pathogenic Mutation.
Mitochondrial Diseases
HIBCH deficiency in a patient with phenotypic characteristics of mitochondrial disorders.
Mitochondrial Diseases
MRI of 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency.
Movement Disorders
A movement disorder with dystonia and ataxia caused by a mutation in the HIBCH gene.
Muscle Hypotonia
MRI of 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency.
Neoplasms
Proteomic Analysis of the Breast Cancer Brain Metastasis Microenvironment.
Neoplasms
Sustained complete response to CTLA-4 blockade in a patient with metastatic, castration-resistant prostate cancer.
Neoplasms
Targeting HIBCH to reprogram valine metabolism for the treatment of colorectal cancer.
Neurodegenerative Diseases
A movement disorder with dystonia and ataxia caused by a mutation in the HIBCH gene.
Neurodegenerative Diseases
Paroxysmal Dyskinesias Revealing 3-Hydroxy-Isobutyryl-CoA Hydrolase (HIBCH) Deficiency.
Neurodegenerative Diseases
Syndromic progressive neurodegenerative disease of infancy caused by novel variants in HIBCH: Report of two cases in Colombia.
Prostatic Neoplasms
Sustained complete response to CTLA-4 blockade in a patient with metastatic, castration-resistant prostate cancer.
Pyruvate Dehydrogenase Complex Deficiency Disease
Thiamine-Responsive and Non-responsive Patients with PDHC-E1 Deficiency: A Retrospective Assessment.
Seizures
MRI of 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency.
Syndactyly
Truncating mutations of HIBCH tend to cause severe phenotypes in cases with HIBCH deficiency: a case report and brief literature review.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
malfunction
mutations in the Chy1 gene lead to a deficiency of benzoic acid-containing glucosinolates in the seeds
malfunction
-
the chy1-10 mutation disrupts a peroxisomal HIBYL-CoA hydrolase, causing reduced cold-induction of CBF3 promoter (CBF3-LUC) in chy1-10. Transcription factors (CBFs) also reduced in the chy1 mutant. Chy1-10 mutant plants are more sensitive to freezing treatment than wild-type after cold acclimation. Both the wild-type and chy1 mutant plants are sensitive to darkness-induced starvation at warm temperatures, although chy1 plants are slightly more sensitive. Chy1-10 is allelic to chy1-1 and chy1-3, all of the examined alleles disrupt HIBYL-CoA hydrolase activity similarly. CBF3 overexpression in chy1-10 partially rescues the mutant defects in cold and dark responses. Disruption of the HIBYL-CoA hydrolase causes accumulation of reactive oxygen species
malfunction
-
enzyme deletion results in a loss of symbiotic N2-fixation
malfunction
enzyme deletion results in a loss of symbiotic N2-fixation
malfunction
-
enzyme deletion results in a loss of symbiotic N2-fixation
-
malfunction
-
enzyme deletion results in a loss of symbiotic N2-fixation
-
metabolism
-
enzyme overexpression accelerates L-Ile degradation and triacylglycerol accumulation and results in a lowered L-Ile content
metabolism
-
the enzyme is required for L-valine catabolism and prevents the accumulation of toxic metabolic intermediates, particularly methacrylyl-CoA
metabolism
the enzyme is required for L-valine catabolism and prevents the accumulation of toxic metabolic intermediates, particularly methacrylyl-CoA
metabolism
-
the enzyme is required for L-valine catabolism and prevents the accumulation of toxic metabolic intermediates, particularly methacrylyl-CoA
-
metabolism
-
the enzyme is required for L-valine catabolism and prevents the accumulation of toxic metabolic intermediates, particularly methacrylyl-CoA
-
physiological function
-
a role for peroxisomal metabolism in cold stress signaling, and plant tolerance to cold stress and darkness-induced starvation. Is needed for fatty acid beta-oxidation and valine catabolism
physiological function
-
the enzyme is required for efficient symbiotic nitrogen fixation
physiological function
the enzyme is required for efficient symbiotic nitrogen fixation
physiological function
-
the enzyme is required for efficient symbiotic nitrogen fixation
-
physiological function
-
the enzyme is required for efficient symbiotic nitrogen fixation
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Nurmikko, V.; Puukka, M.; Puukka, R.
Product induction of 3-hydroxyisobutyryl CoA hydrolase in Pseudomonas fluorescens UK-1
Suom. Kemistil. B
45
193-196
1972
Pseudomonas fluorescens, Pseudomonas fluorescens UK-1
-
brenda
Ooiwa, T.; Goto, H.; Tsukamoto, Y.; Hayakawa, T.; Sugiyama, S.; Fujitsuka, N.; Shimomura, Y.
Regulation of valine catabolism in canine tissues: tissue distribution of branched-chain aminotransferase and 2-oxo acid dehydrogenase complex, methacrylyl-CoA hydratase and 3-hydroxyisobutyryl-CoA hydrolase
Biochim. Biophys. Acta
1243
216-220
1995
Canis lupus familiaris
brenda
Hawes, J.W.; Jaskiewicz, J.; Shimomura, Y.; Huang, B.; Bunting, J.; Harper, E.T.; Harris, R.A.
Primary structure and tissue-specific expression of human beta-hydroxyisobutyryl-coenzyme A hydrolase
J. Biol. Chem.
271
26430-26434
1996
Rattus norvegicus, Homo sapiens (Q6NVY1), Homo sapiens
brenda
Shimomura, Y.; Murakami, T.; Fujitsuka, N.; Nakai, N.; Sato, Y.; Sugiyama, S.; Shimomura, N.; Irwin, J.; Hawes, J.W.; Harris, R.A.
Purification and partial characterization of 3-hydroxyisobutyryl-coenzyme A hydrolase of rat liver
J. Biol. Chem.
269
14248-14253
1994
Rattus norvegicus
brenda
Ishigure, K.; Shimomura, Y.; Murakami, T.; Kaneko, T.; Takeda, S.; Inoue, S.; Nomoto, S.; Koshikawa, K.; Nonami, T.; Nakao, A.
Human liver disease decreases methacrylyl-CoA hydratase and beta-hydroxyisobutyryl-CoA hydrolase activities in valine catabolism
Clin. Chim. Acta
312
115-121
2001
Homo sapiens
brenda
Wong, B.J.; Gerlt, J.A.
Divergent function in the crotonase superfamily: an anhydride intermediate in the reaction catalyzed by 3-hydroxyisobutyryl-CoA hydrolase
J. Am. Chem. Soc.
125
12076-12077
2003
Pseudomonas aeruginosa
brenda
Shimomura, Y.; Murakami, T.; Nakai, N.; Huang, B.; Hawes, J.W.; Harris, R.A.
3-Hydroxyisobutyryl-CoA hydrolase
Methods Enzymol.
324
229-240
2000
Homo sapiens, Rattus norvegicus
brenda
Iida, T.; Kamo, M.; Uozumi, N.; Inui, T.; Imai, K.
Further application of a two-step heparin affinity chromatography method using divalent cations as eluents: purification and identification of membrane-bound heparin binding proteins from the mitochondrial fraction of HL-60 cells
J. Chromatogr. B
823
209-212
2005
Homo sapiens
brenda
Loupatty, F.J.; Clayton, P.T.; Ruiter, J.P.; Ofman, R.; Ijlst, L.; Brown, G.K.; Thorburn, D.R.; Harris, R.A.; Duran, M.; Desousa, C.; Krywawych, S.; Heales, S.J.; Wanders, R.J.
Mutations in the gene encoding 3-hydroxyisobutyryl-CoA hydrolase results in progressive infantile neurodegeneration
Am. J. Hum. Genet.
80
195-199
2007
Homo sapiens (Q6NVY1), Homo sapiens
brenda
Lee, S.H.; Park, S.J.; Lee, S.Y.; Hong, S.H.
Biosynthesis of enantiopure (S)-3-hydroxybutyric acid in metabolically engineered Escherichia coli
Appl. Microbiol. Biotechnol.
79
633-641
2008
Bacillus cereus (Q81DR3)
brenda
Dong, C.H.; Zolman, B.K.; Bartel, B.; Lee, B.H.; Stevenson, B.; Agarwal, M.; Zhu, J.K.
Disruption of Arabidopsis CHY1 reveals an important role of metabolic status in plant cold stress signaling
Mol. Plant
2
59-72
2009
Arabidopsis thaliana
brenda
Ibdah, M.; Pichersky, E.
Arabidopsis Chy1 null mutants are deficient in benzoic acid-containing glucosinolates in the seeds
Plant Biol.
11
574-581
2009
Arabidopsis thaliana (Q9LKJ1), Arabidopsis thaliana
brenda
Zamani, M.; diCenzo, G.C.; Milunovic, B.; Finan, T.M.
A putative 3-hydroxyisobutyryl-CoA hydrolase is required for efficient symbiotic nitrogen fixation in Sinorhizobium meliloti and Sinorhizobium fredii NGR234
Environ. Microbiol.
19
218-236
2017
Sinorhizobium meliloti, Sinorhizobium fredii (C3KM96), Sinorhizobium fredii NGR234 (C3KM96), Sinorhizobium fredii NGR234, Sinorhizobium meliloti RmP798
brenda
Pan, Y.; Yang, J.; Gong, Y.; Li, X.; Hu, H.
3-Hydroxyisobutyryl-CoA hydrolase involved in isoleucine catabolism regulates triacylglycerol accumulation in Phaeodactylum tricornutum
Philos. Trans. R. Soc. Lond. B Biol. Sci.
372
20160409
2017
Phaeodactylum tricornutum
brenda