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The enzyme appears in viruses and cellular organisms
Reaction Schemes
diphthine methyl ester-[translation elongation factor 2]
+
=
diphthine-[translation elongation factor 2]
+
Synonyms
wdr85, ybr246w,
more
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Dph7
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YBR246W
locus name
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diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol
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diphthine methyl ester acylhydrolase
The protein is only present in eukaryotes.
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diphthine methyl ester-[translation elongation factor 2] + H2O
diphthine-[translation elongation factor 2] + methanol
diphthine methyl ester-[translation elongation factor 2] + H2O
diphthine-[translation elongation factor 2] + methanol
the enzyme is involved in diphthamide biosynthesis pathway
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-
?
diphthine methyl ester-[translation elongation factor 2] + H2O
diphthine-[translation elongation factor 2] + methanol
diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine
diphthine i.e. 2-[(3S)-3-carboxy-3-(trimethylammonio)propyl]-L-histidine
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?
diphthine methyl ester-[translation elongation factor 2] + H2O
diphthine-[translation elongation factor 2] + methanol
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?
diphthine methyl ester-[translation elongation factor 2] + H2O
diphthine-[translation elongation factor 2] + methanol
the enzyme is involved in diphthamide biosynthesis pathway
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-
?
diphthine methyl ester-[translation elongation factor 2] + H2O
diphthine-[translation elongation factor 2] + methanol
diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine
diphthine i.e. 2-[(3S)-3-carboxy-3-(trimethylammonio)propyl]-L-histidine
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?
diphthine methyl ester-[translation elongation factor 2] + H2O
diphthine-[translation elongation factor 2] + methanol
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-
?
diphthine methyl ester-[translation elongation factor 2] + H2O
diphthine-[translation elongation factor 2] + methanol
the enzyme is involved in diphthamide biosynthesis pathway
-
-
?
diphthine methyl ester-[translation elongation factor 2] + H2O
diphthine-[translation elongation factor 2] + methanol
diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine
diphthine i.e. 2-[(3S)-3-carboxy-3-(trimethylammonio)propyl]-L-histidine
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?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
diphthine methyl ester-[translation elongation factor 2] + H2O
diphthine-[translation elongation factor 2] + methanol
diphthine methyl ester-[translation elongation factor 2] + H2O
diphthine-[translation elongation factor 2] + methanol
the enzyme is involved in diphthamide biosynthesis pathway
-
-
?
diphthine methyl ester-[translation elongation factor 2] + H2O
diphthine-[translation elongation factor 2] + methanol
-
-
-
?
diphthine methyl ester-[translation elongation factor 2] + H2O
diphthine-[translation elongation factor 2] + methanol
the enzyme is involved in diphthamide biosynthesis pathway
-
-
?
diphthine methyl ester-[translation elongation factor 2] + H2O
diphthine-[translation elongation factor 2] + methanol
-
-
-
?
diphthine methyl ester-[translation elongation factor 2] + H2O
diphthine-[translation elongation factor 2] + methanol
the enzyme is involved in diphthamide biosynthesis pathway
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Lymphoma
A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with Deletion of WDR85.
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SwissProt
brenda
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SwissProt
brenda
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SwissProt
brenda
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metabolism
the enzyme is involved in diphthamide biosynthesis pathway
metabolism
the enzyme is involved in diphthamide biosynthesis pathway
metabolism
the eukaryotic enzyme is part of the biosynthetic pathway of diphthamide
metabolism
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the enzyme is involved in diphthamide biosynthesis pathway
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metabolism
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the eukaryotic enzyme is part of the biosynthetic pathway of diphthamide
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DPH7_DICDI
367
0
42561
Swiss-Prot
other Location (Reliability: 1)
DPH7_HUMAN
452
0
50575
Swiss-Prot
other Location (Reliability: 3)
DPH7_MOUSE
477
0
53201
Swiss-Prot
other Location (Reliability: 3)
DPH7_SCHPO
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
326
0
37040
Swiss-Prot
other Location (Reliability: 1)
DPH7_YEAST
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
387
0
43308
Swiss-Prot
other Location (Reliability: 1)
A0A653HCE7_9APIC
303
0
35614
TrEMBL
other Location (Reliability: 2)
A0A0Y9TB39_PLABE
351
0
40664
TrEMBL
other Location (Reliability: 2)
A0A679L0S6_PLAKH
350
0
39726
TrEMBL
other Location (Reliability: 2)
A0A812EZK8_SEPPH
163
4
18533
TrEMBL
Secretory Pathway (Reliability: 3)
A0A8J5C4U0_9ASCO
352
0
39042
TrEMBL
other Location (Reliability: 1)
A0A1C3KZX2_PLAMA
349
0
40290
TrEMBL
other Location (Reliability: 2)
A0A8M1ND87_DANRE
443
0
49204
TrEMBL
other Location (Reliability: 4)
A0A812D276_SEPPH
713
3
80313
TrEMBL
Mitochondrion (Reliability: 5)
A0A1C6Y7I3_PLACH
349
0
40139
TrEMBL
other Location (Reliability: 2)
A0A8J5EIT8_9ASCO
351
0
38904
TrEMBL
other Location (Reliability: 1)
A0A7R8HA87_LEPSM
200
0
22827
TrEMBL
other Location (Reliability: 1)
A0A1C6Y7P7_PLACH
349
0
40139
TrEMBL
other Location (Reliability: 2)
A0A1D3SPH5_PLAMA
348
0
40143
TrEMBL
other Location (Reliability: 2)
A0A1G4H0C1_PLAVI
361
0
40316
TrEMBL
other Location (Reliability: 2)
A0A1D3RRN9_PLACH
349
0
40211
TrEMBL
other Location (Reliability: 2)
A0A1D3RR55_PLACH
349
0
40169
TrEMBL
other Location (Reliability: 2)
A0A6J8BNY2_MYTCO
376
0
42691
TrEMBL
other Location (Reliability: 1)
C6KSS8_PLAF7
345
0
40190
TrEMBL
other Location (Reliability: 2)
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Lin, Z.; Su, X.; Chen, W.; Ci, B.; Zhang, S.; Lin, H.
Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis
J. Am. Chem. Soc.
136
6179-6182
2014
Saccharomyces cerevisiae (P38332), Homo sapiens (Q9BTV6), Homo sapiens, Saccharomyces cerevisiae ATCC 204508 (P38332)
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