Information on EC 3.1.1.8 - cholinesterase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
3.1.1.8
-
RECOMMENDED NAME
GeneOntology No.
cholinesterase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an acylcholine + H2O = choline + a carboxylate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of carboxylic ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
acylcholine acylhydrolase
Acts on a variety of choline esters and a few other compounds.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-08-5
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
silver European eel
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
air-breathing snakehead fish
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Delia floralis
-
-
-
Manually annotated by BRENDA team
isozyme E1 and E2
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
male and female
-
-
Manually annotated by BRENDA team
lizard
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
rhesus macaque, butyrylcholine esterase is the prevalent cholinesterase form in the circulation of adult macaques
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
mussel
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
no activity in Acheta domesticus
-
-
-
Manually annotated by BRENDA team
no activity in Bos taurus
brain and erythrocytes
-
-
Manually annotated by BRENDA team
no activity in Branchiostoma floridae
-
-
-
Manually annotated by BRENDA team
no activity in Electrophorus electricus
electric organ
-
-
Manually annotated by BRENDA team
no activity in Lepomis gibbosus
-
-
-
Manually annotated by BRENDA team
no activity in Solanum melongena
-
-
-
Manually annotated by BRENDA team
no activity in Tetranychus urticae
-
-
-
Manually annotated by BRENDA team
no activity in Torpedo marmorata
electric organ
-
-
Manually annotated by BRENDA team
no activity in Triatoma infestans
-
-
-
Manually annotated by BRENDA team
no activity in Zea mays
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
English sole flatfish
-
-
Manually annotated by BRENDA team
Pavo sp.
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
pheasant
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
female and male Hornyhead turbot
-
-
Manually annotated by BRENDA team
a freshwater snail
-
-
Manually annotated by BRENDA team
strain K, inducible enzyme
-
-
Manually annotated by BRENDA team
marbled sole
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
eggplant, Black Beauty
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
a freshwater snail
-
-
Manually annotated by BRENDA team
mung bean
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
low paraoxonase-1 catalytic efficiency and low plasma PON1 activity in human are associated with BuChE inhibition among organophosphate-exposed agricultural pesticide handlers
additional information
-
cholinesterase does not ungergo disease-related modification in the primary structure during Alzheimer's disease
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+)-cocaine + H2O
?
show the reaction diagram
(+/-)-cocaine + H2O
?
show the reaction diagram
-
-
-
-
?
(-)-cocaine + H2O
?
show the reaction diagram
(R)-3-benzoyloxy-1-benzylquinuclidinium bromide + H2O
?
show the reaction diagram
-
-
-
?
(R)-3-benzoyloxy-1-methylquinuclidinium iodide + H2O
?
show the reaction diagram
-
-
-
?
(S)-3-benzoyloxy-1-benzylquinuclidinium bromide + H2O
?
show the reaction diagram
-
-
-
?
(S)-3-benzoyloxy-1-methylquinuclidinium iodide + H2O
?
show the reaction diagram
-
-
-
?
2,2,2-trifluoro-N-(2-nitrophenyl)acetamide + H2O
2-nitroaniline + trifluoroacetate
show the reaction diagram
-
a neutral amide
-
-
?
2,6-dichloro-3'-methylindophenylacetate + H2O
2,6-dichloro-3'-methylindophenol + acetate
show the reaction diagram
-
-
-
?
2,6-dichlorophenolindophenyl acetate + H2O
?
show the reaction diagram
-
-
-
-
?
2,6-dichlorophenolindophenylacetate + H2O
2,6-dichlorophenolindophenol + acetate
show the reaction diagram
-
good substrate
-
?
2,6-dichlorophenolindophenylacetate + H2O
?
show the reaction diagram
-
-
-
-
?
2-nitroacetanilide + H2O
2-nitroaniline + acetate
show the reaction diagram
-
a neutral amide
-
-
?
2-nitrophenyl butyrate
2-nitrophenol + butyrate
show the reaction diagram
-
-
-
?
2-trimethylsilyl-ethyl-N-n-butylcarbamate + H2O
?
show the reaction diagram
-
-
-
-
?
3',5'-dichloro-2'-methylindophenylacetate + H2O
3',5'-dichloro-2'-methylindophenol + acetate
show the reaction diagram
-
weak substrate
-
?
3',5'-dichlorophenolindophenylacetate + H2O
3',5'-dichlorophenolindophenol + acetate
show the reaction diagram
-
-
-
?
3,3-dimethylbutyl-N-n-butylcarbamate + H2O
?
show the reaction diagram
-
-
-
-
?
3-(acetamido) N,N,N-trimethylanilinium + H2O
3-amino-N,N,N-trimethylanilinium + acetate
show the reaction diagram
-
a positively charged amide, hydrolysis by the wild-type enzyme and the mutant D70G shows a long transient phase preceeding the steady state, hysteretic burst induction phase, overview
-
-
?
3-(acetamido)N,N,N-trimethylanilinium + H2O
?
show the reaction diagram
-
-
-
-
?
3-nitroacetanilide + H2O
3-nitroaniline + acetate
show the reaction diagram
-
a neutral amide
-
-
?
7-ethyl-10-[4-(1-piperidine)-1-piperidino]carbonyloxycamtothecin + H2O
7-ethyl-10-hydroxycamptothecin + ?
show the reaction diagram
anticancer drug irinotecan CPT-11
-
?
acetoacetylcholine + H2O
acetoacetate + choline
show the reaction diagram
-
-
-
-
?
acetyl choline + H2O
acetate + choline
show the reaction diagram
-
enzyme also acts on acetyl choline to a lesser extent
-
?
acetyl-beta-methylcholine
beta-methylcholine + acetate
show the reaction diagram
acetyl-beta-methylcholine + H2O
acetate + beta-methylcholine
show the reaction diagram
acetyl-beta-methylcholine + H2O
methylcholine + acetate
show the reaction diagram
-
-
-
?
acetyl-beta-methylthiocholine + H2O
acetate + beta-methylcholine
show the reaction diagram
-
-
-
-
?
acetyl-beta-methylthiocholine + H2O
beta-methylthiocholine + acetate
show the reaction diagram
acetylcholine + H2O
acetate + choline
show the reaction diagram
acetylcholine + H2O
choline + acetate
show the reaction diagram
acetylsalicylic acid + H2O
acetate + salicylate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
?
show the reaction diagram
-
detection with 5,5-dithiobis(2-nitrobenzoic acid)
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
acetylthiocholine iodide + H2O
?
show the reaction diagram
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
acetylthiocholine iodide + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
?
adipyldicholine + H2O
adipic acid + choline
show the reaction diagram
-
lower activity, monitoring the dicholine substrates, the monocholine intermediates, the dicarboxylic acid and choline products by mass spectrometry,
-
-
?
benzoylcholine + H2O
benzoate + choline
show the reaction diagram
benzoylcholine + H2O
benzoic acid + choline
show the reaction diagram
-
-
-
-
?
benzoylcholine + H2O
choline + benzoate
show the reaction diagram
benzoylthiocholine + H2O
?
show the reaction diagram
-
-
-
-
?
benzoylthiocholine + H2O
thiocholine + benzoate
show the reaction diagram
beta-hydroxybutyrylcholine + H2O
3-hydroxybutanoate + choline
show the reaction diagram
-
-
-
-
?
butyryl choline + H2O
butyrate + choline
show the reaction diagram
-
preferred substrate
-
?
butyrylcholine + H2O
butanoate + choline
show the reaction diagram
butyrylcholine + H2O
butyrate + choline
show the reaction diagram
butyrylcholine + H2O
choline + butyrate
show the reaction diagram
butyrylcholine iodide + H2O
?
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
?
show the reaction diagram
butyrylthiocholine + H2O
butanoate + choline
show the reaction diagram
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
butyrylthiocholine chloride + H2O
?
show the reaction diagram
-
-
-
-
?
butyrylthiocholine iodide + H2O
?
show the reaction diagram
-
-
-
-
?
butyrylthiocholine iodide + H2O
butyrate + thiocholine iodide
show the reaction diagram
butyrylthiocholine iodide + H2O
thiocholine + butyrate
show the reaction diagram
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
butyrylthiocholinium chloride + H2O
?
show the reaction diagram
-
-
-
-
?
bytyrylhiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
choline esters + H2O
?
show the reaction diagram
cocaine + H2O
?
show the reaction diagram
cocaine + H2O
ecgonine methyl ester + benzoate
show the reaction diagram
crotonylcholine + H2O
crotonate + choline
show the reaction diagram
-
-
-
-
?
D-butyryl-alpha-methylcholine + H2O
butanoate + alpha-methylcholine
show the reaction diagram
D-butyryl-beta-methylcholine + H2O
butanoate + beta-methylcholine
show the reaction diagram
echothiophate + H2O
?
show the reaction diagram
-
substrate for mutant enzyme G117H
-
-
?
ethyl ([2-[bis(propan-2-yl)amino]ethyl]-sulfanyl)(methyl)phosphinate + H2O
?
show the reaction diagram
-
substrate for mutant enzyme G117H
-
-
?
ethyl n-butyrate + H2O
ethanol + n-butanoate
show the reaction diagram
heroin + H2O
?
show the reaction diagram
-
-
-
-
?
indophenyl acetate + H2O
?
show the reaction diagram
-
-
-
-
?
indophenylacetate + H2O
?
show the reaction diagram
-
-
-
-
?
indophenylacetate + H2O
indophenol + acetate
show the reaction diagram
-
-
-
?
isoamyl isovalerate + H2O
isopentanol + isopentanoate
show the reaction diagram
-
poor substrate
-
-
?
isoamyl n-butyrate + H2O
isopentanol + n-butanoate
show the reaction diagram
-
-
-
-
?
isoamyl propionate + H2O
isopentanol + propanoate
show the reaction diagram
-
-
-
-
?
isobutyl isovalerate + H2o
isobutanol + isopentanoate
show the reaction diagram
-
poor substrate
-
-
?
isobutyl n-butyrate + H2O
isobutanol + n-butanoate
show the reaction diagram
-
-
-
-
?
isobutyl propionate + H2O
isobutanol + propanoate
show the reaction diagram
-
poor substrate
-
-
?
L-butyryl-alpha-methylcholine + H2O
butanoate + alpha-methylcholine
show the reaction diagram
L-butyryl-beta-methylcholine + H2O
butanoate + beta-methylcholine
show the reaction diagram
methyl n-butyrate + H2O
methanol + n-butanoate
show the reaction diagram
-
poor substrate
-
-
?
methyl n-valerate + H2O
methanol + n-pentanoate
show the reaction diagram
-
poor substrate
-
-
?
n-amyl acetate + H2O
n-pentanol + acetate
show the reaction diagram
-
poor substrate
-
-
?
n-amyl n-butyrate + H2O
n-pentanol + n-butanoate
show the reaction diagram
-
good substrate
-
-
?
n-butyl acetate + H2O
n-butanol + acetate
show the reaction diagram
-
poor substrate
-
-
?
n-butyl n-butyrate + H2O
n-butanol + n-butanoate
show the reaction diagram
-
poor substrate
-
-
?
n-hexyl acetate + H2O
n-hexanol + acetate
show the reaction diagram
-
poor substrate
-
-
?
N-methyl-(7-dimethylcarbamoxy)quinolinium iodide + H2O
?
show the reaction diagram
-
atypical and usual enzyme
-
-
?
N-methylindoxyl acetate + H2O
N-methylindole + acetate
show the reaction diagram
-
-
-
?
O-ethyl-O-(4-nitrophenyl)-phenylphosphonothioate + H2O
?
show the reaction diagram
-
-
-
-
?
o-nitrophenylacetate + H2O
?
show the reaction diagram
-
-
-
-
?
o-nitrophenylbutyrate + H2O
o-nitrophenol + butanoate
show the reaction diagram
-
atypical and usual enzyme
-
-
?
phenyl acetate + H2O
phenol + acetate
show the reaction diagram
-
-
-
-
?
phenylthioacetate + H2O
phenol + thioacetate
show the reaction diagram
-
-
-
-
?
phenylthiopropionate + H2O
phenol + thiopropanoate
show the reaction diagram
-
-
-
-
?
propionyl choline + H2O
propionate + choline
show the reaction diagram
-
preferred substrate
-
?
propionylcholine + H2O
propanoate + choline
show the reaction diagram
propionylthiocholine + H2O
?
show the reaction diagram
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
propionylthiocholine + H2O
thiocholine + propanoate
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
propionylthiocholine iodide + H2O
thiocholine + propionate
show the reaction diagram
-
preferred substrate
-
-
?
S-butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
-
?
S-butyrylthiocholine iodide + H2O
butyrate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
sarin + H2O
?
show the reaction diagram
-
substrate for mutant enzyme G117H
-
-
?
sebacyldicholine + H2O
sebacic acid + choline
show the reaction diagram
-
high activity, monitoring the dicholine substrates, the monocholine intermediates, the dicarboxylic acid and choline products by mass spectrometry, sebacyldicholine is hydrolyzed at both choline ester sites, though hydrolysis of dicholine is faster than hydrolysis of monocholine, overview
-
-
?
succinyl dicholine dichloride + H2O
?
show the reaction diagram
succinylcholine + H2O
succinate + choline
show the reaction diagram
succinyldithiocholine + H2O
?
show the reaction diagram
-
-
-
-
?
succinylmonocholine + H2O
succinate + choline
show the reaction diagram
-
-
-
-
?
succinylthiocholine + H2O
thiocholine + succinate
show the reaction diagram
-
-
-
?
valerylthiocholine + H2O
pentanoate + thiocholine
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylsalicylic acid + H2O
acetate + salicylate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
benzoylcholine + H2O
benzoic acid + choline
show the reaction diagram
-
-
-
-
?
butyrylcholine + H2O
butyrate + choline
show the reaction diagram
butyrylcholine + H2O
choline + butyrate
show the reaction diagram
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
choline esters + H2O
?
show the reaction diagram
cocaine + H2O
ecgonine methyl ester + benzoate
show the reaction diagram
-
-
-
-
?
heroin + H2O
?
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ba2+
-
activates
Ca2+
-
activates 9fold at 0.5 mM with substrate O-ethyl-O-(4-nitrophenyl)-phenylphosphonothioate via a specific EF-hand calcium binding site, molecular modelling of Ca2+ binding to EF-hands, disruption by H2O2-mediated oxidation
Mg2+
-
20 mM activates
Zn2+
-
1-2 mM, 10% activation, inhibitory above
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(+)-7-deoxy-O6-buxafurandiene
-
isolated from Buxus hyrcana
(+)-benzoylbuxidienine
-
isolated from Buxus hyrcana
(+)-buxapapillinine
-
isolated from Buxus hyrcana
(+)-buxaquamarine
-
isolated from Buxus hyrcana
(+)-cocaine
-
-
(+)-debromoflustramine B
-
-
(+)-irehine
-
isolated from Buxus hyrcana
(+)-limonene
-
identified compound of Pimpinella anisodes, IC50: 456.2 microgram/ml
(+)-O6-buxafurandiene
-
isolated from Buxus hyrcana
(+)-sabinene
-
identified compound of Pimpinella anisodes, IC50: 218.6 microgram/ml
(-)-10,10-dimethylhuperzine A
-
-
(-)-3-O-acetyl-spectaline
-
isolated from flowers of Senna spectabilis
(-)-Carvone
-
62.4% inhibition at 1 mM
(-)-cocaine
-
-
(-)-debromoflustramine B
-
-
(-)-galanthamine
-
isolated from Galanthus woronowii
(-)-N1-phenethylnorcymserine
-
-
(-)-N1-phenethylnorphenserine
-
-
(-)-N1-phenethylnorphysostigmine
-
-
(-)-phenserine
-
-
(-)-spectaline
-
isolated from flowers of Senna spectabilis
(13E,13'Z)-N,N'-hexane-1,6-diylbis(6,7,8,9,10,11-hexahydro-13H-azocino[2,1-b]quinazolin-13-imine)
-
-
(13Z,13'Z)-N,N'-heptane-1,7-diylbis(6,7,8,9,10,11-hexahydro-13H-azocino[2,1-b]quinazolin-13-imine)
-
-
(1alpha,3beta,22R)-stigmast-5-ene-1,3,22-triol
-
i.e. haloxysterol A, isolated from Haloxylon recurvum
(1alpha,3beta,22R)-stigmasta-4,6-diene-1,3,22-triol
-
i.e. haloxysterol B, isolated from Haloxylon recurvum
(1alpha,3beta,5alpha,6beta,22R)-stigmastane-1,3,5,6,22-pentol
-
i.e. haloxysterol D, isolated from Haloxylon recurvum
(1S,2S,11bS)-4-[2-(acetyloxy)ethyl]-5-methyl-1,2,3,4,4a,5,6,11b-octahydro[1,3]dioxolo[4,5-j]phenanthridine-1,2-diyl diacetate
-
-
(1S,2S,11bS)-4-[2-(acetyloxy)ethyl]-5-methyl-1,2,4a,5,6,11b-hexahydro[1,3]dioxolo[4,5-j]phenanthridine-1,2-diyl diacetate
-
-
(2,6,6-trimethylcyclohex-1-en-1-yl)methyl 6-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
-
-
(2-mercaptoethyl)trimethylammonium iodide O,O-diethyl phosphorothioate
-
0.2 mM, 21% inhibition; i.e. echothiophate
-
(22R)-22-hydroxystigmasta-4,9(11)-dien-3-one
-
i.e. haloxysterol , isolated from Haloxylon recurvum
(24S)-ethylcholesta-7,9(11),22(E)-triene-3beta-ol
-
isolated from Haloxylon recurvum
(2E)-1,3-diphenylprop-2-en-1-one
-
-
(2E)-1-(5-chloro-2-hydroxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one
-
-
(2E)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(3,4-dimethoxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(3-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2x)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-([[(2E)-3-phenylprop-2-enoyl]oxy]carbonyl)-D-arabino-hexitol
-
96% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(2-methylbutanoyl)-D-arabino-hexitol
-
99% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(biphenyl-4-ylcarbonyl)-D-arabino-hexitol
-
99% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(carboxycarbamoyl)-D-arabino-hexitol
-
92% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(cyclopentylcarbonyl)-D-arabino-hexitol
-
99% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(cyclopropylcarbonyl)-D-arabino-hexitol
-
97% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(phenoxycarbonyl)-D-arabino-hexitol
-
99% inhibition at 0.1 mM, highly selective for BuChE, with about 50000fold selectivity over human erythrocyte acetylcholinesterase. Competitive, and slowly reversible inhibition by active site carbamylation
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-([[(4-methylphenyl)sulfonyl]oxy]carbonyl)-D-arabino-hexitol
-
25% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-([[(trifluoromethyl)sulfonyl]oxy]carbonyl)-D-arabino-hexitol
-
85% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[(2H-chromen-2-yloxy)carbonyl]-D-arabino-hexitol
-
100% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[(3,4-dihydroxyphenyl)carbonyl]-D-arabino-hexitol
-
38% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[(pentanoyloxy)carbonyl]-D-arabino-hexitol
-
95% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[(propanoyloxy)carbonyl]-D-arabino-hexitol
-
97% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[([[4-(heptyloxy)phenyl]carbonyl]oxy)carbonyl]-D-arabino-hexitol
-
80% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[[(methylsulfonyl)oxy]carbonyl]-D-arabino-hexitol
-
9.8% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[[(naphthalen-2-ylcarbonyl)oxy]carbonyl]-D-arabino-hexitol
-
100% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[[(pyridin-3-ylcarbonyl)oxy]carbonyl]-D-arabino-hexitol
-
99% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[[(pyridin-4-ylcarbonyl)oxy]carbonyl]-D-arabino-hexitol
-
97% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-([2-[(carbamoyloxy)methyl]-5-hydroxybenzyl]carbamoyl)-D-arabino-hexitol
-
95% inhibition at 0.1 mM
(2xi)-5-O-[(acetyloxy)carbonyl]-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-D-arabino-hexitol
-
97% inhibition at 0.1 mM
(2Z)-4-[(2-aminophenyl)amino]-4-oxobut-2-enoic acid
-
one of the best inhibitors
(2Z)-4-[(4-nitrophenyl)amino]-4-oxobut-2-enoic acid
-
weak inhibition
(3,4-dimethoxyphenyl)(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methanol
-
-
(3,4-dimethoxyphenyl)-(4-([(2-dimethylaminoethyl)-methylamino]methyl)phenyl)-methanone
-
-
(3,4-dimethoxyphenyl)-(4-([(2-methoxybenzyl)methylamino]methyl)phenyl)-methanone
-
-
(3,4-dimethoxyphenyl)-(4-([methyl-(3-methylbenzyl)amino]methyl)phenyl)methanone
-
-
(3,4-dimethoxyphenyl)-(4-([methyl-(3-nitrobenzyl)amino]methyl)phenyl)methanone
-
-
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl (2-methylphenyl)carbamate
-
50% inhibition at 1950 nM
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 50 nM
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl ethylcarbamate
-
50% inhibition at 4 nM
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl methylcarbamate
-
50% inhibition at 16 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl (2-methylphenyl)carbamate
-
50% inhibition at 1560 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 17 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl ethylcarbamate
-
50% inhibition at 2 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl methylcarbamate
-
50% inhibition at 4 nM
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2-phenylethyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3,4-dimethoxyphenyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-acetylphenyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-butylphenyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-chlorophenyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-methoxyphenyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-nitrophenyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-phenoxyphenyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-tert-butylphenyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (cyclohexylmethyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl 1,3-benzodioxol-5-ylcarbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl benzylcarbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl biphenyl-4-ylcarbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl cyclohexylcarbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl hexylcarbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl naphthalen-2-ylcarbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl [4-(dimethylamino)phenyl]carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl [4-(hexyloxy)phenyl]carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,3-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,4,6-trimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,4-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,5-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,6-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2-ethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3,4-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3-methylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-methylphenyl)carbamate
-
-
(3beta,4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,28-dihydroxy-3-methoxy-1,26-dioxo-5,6:22,26-diepoxyergost-24-en-19-oic acid
-
isolated from Withania somnifera, noncompetitive inhibition
(3beta,4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,28-dihydroxy-3-methoxy-5,6:22,26-diepoxyergost-24-ene-1,26-dione
-
isolated from Withania somnifera, noncompetitive inhibition
(3beta,4beta,6beta,8xi,9xi,14xi,17xi,22R)-4,6,27-trihydroxy-3-methoxy-22,26-epoxyergost-24-ene-1,26-dione
-
isolated from Withania somnifera, noncompetitive inhibition
(3E)-3-([4-[2-(diethylamino)ethoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-([4-[3-(diethylamino)propoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-[(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-[(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3R,4aS,9bS)-9-(chloromethyl)-9b-[2-[(ethoxycarbonyl)(methyl)amino]ethyl]-6-methoxy-3,4,4a,9b-tetrahydrodibenzo[b,d]furan-3-yl ethyl carbonate
-
-
(4-([benzyl-(2-dimethylaminoethyl)amino]methyl)-phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-([benzyl-(2-hydroxyethyl)amino]methyl)phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-[(benzylethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)-(3-fluoro-4-methoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)-(4-methoxyphenyl)methanone
-
-
(4-[3-(benzylmethylamino)propenyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4aS,6R,8aS)-3-methoxy-11-methyl-5,6,10,11,13,14-hexahydro-4aH,9H-[1]benzofuro[3a,3,2-gh][3,4]benzoxazonin-6-ol
-
-
(4aS,6R,8aS)-3-methoxy-11-[8-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]octyl]-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol
-
-
(4aS,6R,8aS)-3-[[12-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)dodecyl]oxy]-6-hydroxy-11-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-3-[[8-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]oxy]-6-hydroxy-11-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-[10-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]decyl]-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-[8-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]octyl]-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methyl-11-(10-phenyldecyl)-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methyl-11-(8-phenyloctyl)-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,27-dihydroxy-5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione
-
isolated from Ajuga bracteosa, noncompetitive inhibition
(5alpha,6alpha,7alpha,8xi,9xi,14xi,17xi,22R)-5-hydroxy-20-methyl-6,7:22,26-diepoxyergosta-2,24-diene-1,26-dione
-
isolated from Ajuga bracteosa, noncompetitive inhibition
(6,7-dimethoxyisoquinolin-1-yl)(2-methoxyphenyl)methanol
-
-
(6,7-dimethoxyisoquinolin-1-yl)(3,4-dimethoxyphenyl)methanol
-
-
(6,7-dimethoxyisoquinolin-1-yl)(3,4-dimethoxyphenyl)methanone
-
-
(8Z)-5,6-dihydro-8H-isoquino[1,2b]quinazolin-8-imine
-
-
(9E,9'E)-N,N'-hexane-1,6-diylbis(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-imine)
-
-
(9E,9'Z)-N,N'-heptane-1,7-diylbis(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-imine)
-
-
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
(S)-3-benzoyloxy-1-benzylquinuclidinium bromide
-
inhibition at 0.01 mM and 0.02 mM
(Z)-N1-methyl-N4-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylidene)-N1-(3-((E)-8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)-butane-1,4-diamine
-
-
1,1'-(2E)-but-2-ene-1,4-diyldipyridinium dibromide
-
-
1,1'-(2Z)-but-2-ene-1,4-diyldipyridinium dichloride
-
-
1,1'-(benzene-1,2-diyldimethanediyl)dipyridinium dibromide
-
-
1,1'-(benzene-1,3-diyldimethanediyl)dipyridinium dibromide
-
-
1,1'-(benzene-1,4-diyldimethanediyl)dipyridinium dibromide
-
-
1,1'-(naphthalene-2,7-diyldimethanediyl)dipyridinium dibromide
-
-
1,1'-(oxydiethane-2,1-diyl)dipyridinium dibromide
-
-
1,1'-(oxydimethanediyl)dipyridinium dichloride
-
-
1,1'-butane-1,4-diyldipyridinium dibromide
-
-
1,1'-decane-1,10-diyldipyridinium dibromide
-
-
1,1'-heptane-1,7-diyldipyridinium dibromide
-
-
1,1'-hexane-1,6-diyldipyridinium dibromide
-
-
1,1'-nonane-1,9-diyldipyridinium dibromide
-
-
1,1'-octane-1,8-diyldipyridinium dibromide
-
-
1,1'-pentane-1,5-diyldipyridinium dibromide
-
-
1,1'-undecane-1,11-diyldipyridinium dibromide
-
-
1,2,11,12-tetramethoxy-7-methyl-5,6-dihydro-4H,8H-pyrido[3,2,1-de]phenanthridinium
-
-
1,2,3,10,11-pentamethoxy-7-(methoxycarbonyl)-5,6-dihydro-4H,8H-pyrido[3,2,1-de]phenanthridinium
-
-
1,2,3,4,9,9a-hexahydroacridin-9-amine
-
-
1,2-di(berberine-9-O-yl)ethane dibromide
-
-
1,2-diacetyllycorine
-
-
1,2-dimethyl-beta-carbolin-2-ium iodide
-
noncompetitive inhibition
-
1,3-di(berberine-9-O-yl)propane dibromide
-
-
1,3a,8-tris(3-methylbut-2-enyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
-
-
1,4-dichlorobenzene
-
reversible
1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-nitro-D-threo-hexitol
-
96% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-(butylcarbamoyl)-5-O-nitro-D-threo-hexitol
-
92% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-(cyclohexylcarbamoyl)-5-O-nitro-D-threo-hexitol
-
99% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-(ethylcarbamoyl)-5-O-nitro-D-threo-hexitol
-
73% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-(methylcarbamoyl)-5-O-nitro-D-threo-hexitol
-
82% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-nitro-5-O-(phenylcarbamoyl)-D-threo-hexitol
-
37% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-nitro-5-O-(propylcarbamoyl)-D-threo-hexitol
-
93% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-nitro-5-O-[[4-(trifluoromethyl)phenyl]carbamoyl]-D-threo-hexitol
-
10% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-[(2-chlorophenyl)carbamoyl]-5-O-nitro-D-threo-hexitol
-
11% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-[(3,4-dichlorophenyl)carbamoyl]-5-O-nitro-D-threo-hexitol
-
28% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-[(3-chlorophenyl)carbamoyl]-5-O-nitro-D-threo-hexitol
-
11% inhibition at 0.1 mM
1,5,6-trimethyl-9-oxo-7H,9H-pyrano[3,4,5-ij]isoquinolin-1-ium
-
-
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one
1,5-bis-(4-allyldimethyl-ammoniumphenyl)-pentan-3-one dibromide
-
i.e. BW284c51, cholinesterase from male fish is more sensitive to inhibition
1,8-cineole
1-(2-nitrophenyl)-1H-pyrrole-2,5-dione
-
weak inhibition
1-(2-nitrophenyl)pyrrolidine-2,5-dione
-
weak inhibition
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
-
-
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methylisoquinolinium
-
-
1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline
-
-
1-(3-aminophenyl)pyrrolidine-2,5-dione
-
one of the best inhibitors
1-(hydroxymethyl)-5-methyloctahydro-2H-quinolizinium
1-benzyl-5-methoxy-3a,8-bis(3-methylbut-2-enyl)-1,2,3,3a,8,8ahexahydropyrrolo[2,3-b]indole
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1-dehydrotestosterone
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1-epideacetylbowdensine
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1-methyl-1-[2-oxo-3-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)propyl]pyrrolidinium
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1-methyl-1-[3-oxo-4-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)butyl]pyrrolidinium
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1-methyl-1-[4-oxo-5-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)pentyl]pyrrolidinium
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1-methyl-3-(3-(methylamino)cyclohexyl)pyridinium
1-methyl-4,5-dihydro[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-6-ium-2-olate
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1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl (2-methylphenyl)carbamate
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50% inhibition above 0.030 mM
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl (4-isopropylphenyl)carbamate
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50% inhibition at 22 nM
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl ethylcarbamate
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50% inhibition at 24 nM
1-methylcarbamoyloxy-naphthalene
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0.2 mM, 19% inhibition; i.e. sevin
1-naphthyl methyl carbamate
1-naphthyl phenothiazine carbamate
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1-p-menthanol, 2-dimethylamino-, 2,5-dimethylbenzyl chloride
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Q 80, growth retardant, 0.1 mM, 32% inhibition
1-[2-(4-carboxyphenyl)-5-(ethoxycarbonyl)-1H-benzimidazol-1-yl]-4-ethylmorpholin-1-ium
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10-(2,2-dimethylpropanoyl)-10H-phenothiazine
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relative potency EC 3.1.1.8 to EC 3.1.1.7 is 4.7
10-(2-ethylbutanoyl)-10H-phenothiazine
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not inhibitory to EC 3.1.1.7
10-(3,3-dimethylbutanoyl)-10H-phenothiazine
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not inhibitory to EC 3.1.1.7
10-(3-methylbutanoyl)-10H-phenothiazine
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not inhibitory to EC 3.1.1.7
10-(chloroacetyl)-10H-phenothiazine
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relative potency EC 3.1.1.8 to EC 3.1.1.7 is 7.3
10-(cyclobutylcarbonyl)-10H-phenothiazine
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relative potency EC 3.1.1.8 to EC 3.1.1.7 is 11.6
10-(cycloheptylcarbonyl)-10H-phenothiazine
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not inhibitory to EC 3.1.1.7
10-(cyclohexylacetyl)-10H-phenothiazine
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not inhibitory to EC 3.1.1.7
10-(cyclohexylcarbonyl)-10H-phenothiazine
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not inhibitory to EC 3.1.1.7
10-(cyclopentylacetyl)-10H-phenothiazine
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not inhibitory to EC 3.1.1.7
10-(cyclopentylcarbonyl)-10H-phenothiazine
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not inhibitory to EC 3.1.1.7
10-(cyclopropylcarbonyl)-10H-phenothiazine
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relative potency EC 3.1.1.8 to EC 3.1.1.7 is 1.9
10-(methoxyacetyl)-10H-phenothiazine
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relative potency EC 3.1.1.8 to EC 3.1.1.7 is 0.8
10-acetyl-10H-phenothiazine
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relative potency EC 3.1.1.8 to EC 3.1.1.7 is 1.1
10-butyryl-10H-phenothiazine
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relative potency EC 3.1.1.8 to EC 3.1.1.7 is 1.9
10-heptanoyl-10H-phenothiazine
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not inhibitory to EC 3.1.1.7
10-hexanoyl-10H-phenothiazine
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not inhibitory to EC 3.1.1.7
10-isobutyryl-10H-phenothiazine
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relative potency EC 3.1.1.8 to EC 3.1.1.7 is 2.7
10-methoxy-9-(4-phenoxybutoxy)-5,6-dihydro[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium bromide
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10-N-demethyl-10-N-(10-(4-(piperidin-1-ylmethyl)-phenoxy)decan-1-yl)-galanthamine
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10-N-demethyl-10-N-(12-(4-(piperidin-1-ylmethyl)-phenoxy)dodecan-1-yl)-galanthamine
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10-N-demethyl-10-N-(2-(4-(piperidin-1-ylmethyl)phenoxy)ethan-1-yl)-galanthamine
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10-N-demethyl-10-N-(3-(4-(piperidin-1-ylmethyl)phenoxy)propan-1-yl)-galanthamine
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10-N-demethyl-10-N-(4-(1-benzylpiperidin-4-yloxy)-butan-1-yl)-galanthamine
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10-N-demethyl-10-N-(4-(3-(1-morpholinoethyl)phenoxy)butan-1-yl)-galanthamine
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10-N-demethyl-10-N-(4-(4-((diethylamino)methyl)-phenoxy)butan-1-yl)-galanthamine
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10-N-demethyl-10-N-(4-(4-(morpholinomethyl)phenoxy)butan-1-yl)-galanthamine
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10-N-demethyl-10-N-(4-(4-(piperidin-1-ylmethyl)phenoxy)butan-1-yl)-galanthamine
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10-N-demethyl-10-N-(4-(4-(pyrrolidine-1-carbonyl)-phenoxy)butan-1-yl)-galanthamine
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10-N-demethyl-10-N-(5-(4-(piperidin-1-ylmethyl)phenoxy)pentan-1-yl)-galanthamine
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10-N-demethyl-10-N-(6-(1-benzylpiperidin-4-yloxy)-hexan-1-yl)-galanthamine
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10-N-demethyl-10-N-(6-(3-(1-morpholinoethyl)phenoxy)hexan-1-yl)-galanthamine
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10-N-demethyl-10-N-(6-(4-((diethylamino)methyl)-phenoxy)hexan-1-yl)-galanthamine
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10-N-demethyl-10-N-(6-(4-(morpholinomethyl)phenoxy)hexan-1-yl)-galanthamine
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10-N-demethyl-10-N-(6-(4-(piperidin-1-ylmethyl)phenoxy)hexan-1-yl)-galanthamine
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10-N-demethyl-10-N-(6-(4-(pyrrolidine-1-carbonyl)-phenoxy)hexan-1-yl)-galanthamine
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10-N-demethyl-10-N-(8-(4-(piperidin-1-ylmethyl)phenoxy)octan-1-yl)-galanthamine
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10-N-demethyl-10-N-(9-(4-(piperidin-1-ylmethyl)phenoxy)nonan-1-yl)-galanthamine
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10-pentanoyl-10H-phenothiazine
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not inhibitory to EC 3.1.1.7
10-propionyl-10H-phenothiazine
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relative potency EC 3.1.1.8 to EC 3.1.1.7 is 1.8
10-[4-[(diethylamino)methyl]phenoxy]-N,N-diethyldecan-1-amine
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10-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropyldecan-1-amine
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11alpha,17beta-dihydroxyandrost-1,4-dien-3-one
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11alpha-hydroxyandrost-1,4-dien-3,17-dione
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11alpha-hydroxyandrost-4-en-3,17-dione
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11alpha-hydroxytestolactone
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11alpha-hydroxytestosterone
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12-n-butoxy-demethoxykesselringine
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13-methyl-5,8-dihydro-6H isoquino[1,2b]quinazolin-13-ium chloride