Information on EC 3.1.1.8 - cholinesterase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
3.1.1.8
-
RECOMMENDED NAME
GeneOntology No.
cholinesterase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
an acylcholine + H2O = choline + a carboxylate
show the reaction diagram
enzyme is able to stabilize covalent tetrahedral intermediate adduct with substrate
-
an acylcholine + H2O = choline + a carboxylate
show the reaction diagram
molecular dynamics simulation in aqueous solution, nucleophilic S198 and the various binding subsites in the catalytic cavitiy are readily accessible from the exterior of the protein, the catalytic triad E325/H438/S198 is stablized by presence of a sodium ion
-
an acylcholine + H2O = choline + a carboxylate
show the reaction diagram
the catalytic residue is Ser198
-
an acylcholine + H2O = choline + a carboxylate
show the reaction diagram
mechanism
-
an acylcholine + H2O = choline + a carboxylate
show the reaction diagram
mechanism
-
an acylcholine + H2O = choline + a carboxylate
show the reaction diagram
mechanism
-
an acylcholine + H2O = choline + a carboxylate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of carboxylic ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
acylcholine acylhydrolase
Acts on a variety of choline esters and a few other compounds.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
acyl choline acylhydrolase
-
-
acylcholine acyl-hydrolase
-
-
acylcholine acyl-hydrolase
-
-
acylcholine acyl-hydrolase
-
-
acylcholine acyl-hydrolase
-
-
acylcholine acyl-hydrolase
Pavo sp., pheasant
-
-
Acylcholine acylhydrolase
-
-
-
-
Acylcholine acylhydrolase
-
-
anticholinesterase
-
-
-
-
atypical cholinesterase
-
-
BChE
-
-
BChE
-
-
BChE
-
-
benzoylcholinesterase
-
-
-
-
BtChoEase
-
-
butyrocholinesterase
-
-
butyryl-ChE
-
-
butyrylChE
-
-
butyrylcholine esterase
-
-
-
-
butyrylcholine-hydrolyzing enzyme
-
-
butyrylcholinesterase
-
-
butyrylcholinesterase
-
-
butyrylcholinesterase
-
-
butyrylcholinesterase
P06276
-
butyrylcholinesterase
-
-
butyrylcholinesterase
-
-
butyrylcholinesterase
-
-
butyrylcholinesterase
-
-
butyrylcholinesterase
-
-
butyrylcholinesterase
-
-
butyrylcholinesterase
-
-
butyrylcholinesterase K
-
-
calcium-activated butyrylcholinesterase
-
-
ChE
-
-
ChE-II
-
-
choline esterase
-
-
choline esterase II (unspecific)
-
-
-
-
cholinesterase
-
-
cholinesterase
-
-
cholinesterase
-
-
cholinesterase
-
-
cholinesterase
-
-
cholinesterase
-
-
cholinesterase
-
-
cholinesterase
-
-
EQ-BCHE
-
-
-
-
EqBuChE
-
-
esterase, butyrylcholine
-
-
-
-
esterase, choline
-
-
-
-
hBChE
-
-
monomeric butyrylcholinesterase I
-
-
non specific cholinesterase
-
-
non-specific cholinesterase
-
-
-
-
non-specific cholinesterase
-
-
propionylcholinesterase
-
-
-
-
propionylcholinesterase
-
-
pseudo choline esterase
-
-
pseudo cholinesterase
-
-
pseudocholinesterase
-
-
pseudocholinesterase
-
-
pseudocholinesterase
-
-
pseudocholinesterase
-
-
pseudocholinesterase
-
-
pseudocholinesterase
-
-
serum cholinesterase
-
-
serum cholinesterase
-
-
monomeric butyrylcholinesterase II
-
-
additional information
-
cf. EC 3.1.1.7
additional information
-
cf. EC 3.5.1.13
CAS REGISTRY NUMBER
COMMENTARY
9001-08-5
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
silver European eel
-
-
Manually annotated by BRENDA team
commander squid
-
-
Manually annotated by BRENDA team
air-breathing snakehead fish
-
-
Manually annotated by BRENDA team
Delia floralis
-
-
-
Manually annotated by BRENDA team
isozyme E1 and E2
-
-
Manually annotated by BRENDA team
commercial preparation
-
-
Manually annotated by BRENDA team
male and female
-
-
Manually annotated by BRENDA team
Brasilian population, gene BCHE
-
-
Manually annotated by BRENDA team
exogenously administered in Mus musculus
-
-
Manually annotated by BRENDA team
healthy persons and hemodialysis patients
-
-
Manually annotated by BRENDA team
isoform serum pseudocholinesterase
-
-
Manually annotated by BRENDA team
K variant of gene BCHE
-
-
Manually annotated by BRENDA team
native enzyme and recombinant enzyme expressed in milk of transgenic goat
-
-
Manually annotated by BRENDA team
rhesus macaque, butyrylcholine esterase is the prevalent cholinesterase form in the circulation of adult macaques
-
-
Manually annotated by BRENDA team
female albino mouse
-
-
Manually annotated by BRENDA team
recombinant enzyme
-
-
Manually annotated by BRENDA team
wild-type mice and mdx-mice with adult mdx-muscles malformed with distorted neuromuscular junctions and impaired regulation of acetylcholine receptors
-
-
Manually annotated by BRENDA team
mussel
-
-
Manually annotated by BRENDA team
no activity in Acheta domesticus
-
-
-
Manually annotated by BRENDA team
no activity in Bos taurus
brain and erythrocytes
-
-
Manually annotated by BRENDA team
no activity in Branchiostoma floridae
-
-
-
Manually annotated by BRENDA team
no activity in Electrophorus electricus
electric organ
-
-
Manually annotated by BRENDA team
no activity in Lepomis gibbosus
-
-
-
Manually annotated by BRENDA team
no activity in Solanum melongena
-
-
-
Manually annotated by BRENDA team
no activity in Tetranychus urticae
-
-
-
Manually annotated by BRENDA team
no activity in Torpedo marmorata
electric organ
-
-
Manually annotated by BRENDA team
no activity in Triatoma infestans
-
-
-
Manually annotated by BRENDA team
no activity in Zea mays
-
-
-
Manually annotated by BRENDA team
English sole flatfish
-
-
Manually annotated by BRENDA team
Pavo sp.
-
-
-
Manually annotated by BRENDA team
pheasant
-
-
-
Manually annotated by BRENDA team
female and male Hornyhead turbot
-
-
Manually annotated by BRENDA team
a freshwater snail
-
-
Manually annotated by BRENDA team
induction by growth on choline, acetylcholine or betaine as sole carbon source
-
-
Manually annotated by BRENDA team
strain K, inducible enzyme
-
-
Manually annotated by BRENDA team
Pseudomonas aeruginosa K
strain K, inducible enzyme
-
-
Manually annotated by BRENDA team
eggplant, Black Beauty
-
-
Manually annotated by BRENDA team
Landrace pigs
-
-
Manually annotated by BRENDA team
White Landrace pig and Goettingen minipig
-
-
Manually annotated by BRENDA team
a freshwater snail
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
physiological function
-
low paraoxonase-1 catalytic efficiency and low plasma PON1 activity in human are associated with BuChE inhibition among organophosphate-exposed agricultural pesticide handlers
additional information
-
cholinesterase does not ungergo disease-related modification in the primary structure during Alzheimer's disease
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+)-cocaine + H2O
?
show the reaction diagram
-
-
-
?
(+)-cocaine + H2O
?
show the reaction diagram
-
-
-
?
(+)-cocaine + H2O
?
show the reaction diagram
-
-
-
?
(+/-)-cocaine + H2O
?
show the reaction diagram
-
-
-
-
?
(-)-cocaine + H2O
?
show the reaction diagram
-
-
-
?
(-)-cocaine + H2O
?
show the reaction diagram
-
is hydrolyzed less well than (+)-cocaine
-
?
(-)-cocaine + H2O
?
show the reaction diagram
-
is hydrolyzed less well than (+)-cocaine
-
?
(-)-cocaine + H2O
?
show the reaction diagram
-
unique role of the oxyanion hole G116/G117/A199 in hydrolysis of cocaine, molecular dynamics simulation
-
-
?
(R)-3-benzoyloxy-1-benzylquinuclidinium bromide + H2O
?
show the reaction diagram
-
-
-
?
(R)-3-benzoyloxy-1-methylquinuclidinium iodide + H2O
?
show the reaction diagram
-
-
-
?
(S)-3-benzoyloxy-1-benzylquinuclidinium bromide + H2O
?
show the reaction diagram
-
-
-
?
(S)-3-benzoyloxy-1-methylquinuclidinium iodide + H2O
?
show the reaction diagram
-
-
-
?
2,2,2-trifluoro-N-(2-nitrophenyl)acetamide + H2O
2-nitroaniline + trifluoroacetate
show the reaction diagram
-
a neutral amide
-
-
?
2,6-dichloro-3'-methylindophenylacetate + H2O
2,6-dichloro-3'-methylindophenol + acetate
show the reaction diagram
-
-
-
?
2,6-dichlorophenolindophenyl acetate + H2O
?
show the reaction diagram
-
-
-
-
?
2,6-dichlorophenolindophenylacetate + H2O
2,6-dichlorophenolindophenol + acetate
show the reaction diagram
-
good substrate
-
?
2,6-dichlorophenolindophenylacetate + H2O
?
show the reaction diagram
-
-
-
-
?
2-nitroacetanilide + H2O
2-nitroaniline + acetate
show the reaction diagram
-
a neutral amide
-
-
?
2-nitrophenyl butyrate
2-nitrophenol + butyrate
show the reaction diagram
-
-
-
?
2-trimethylsilyl-ethyl-N-n-butylcarbamate + H2O
?
show the reaction diagram
-
-
-
-
?
3',5'-dichloro-2'-methylindophenylacetate + H2O
3',5'-dichloro-2'-methylindophenol + acetate
show the reaction diagram
-
weak substrate
-
?
3',5'-dichlorophenolindophenylacetate + H2O
3',5'-dichlorophenolindophenol + acetate
show the reaction diagram
-
-
-
?
3,3-dimethylbutyl-N-n-butylcarbamate + H2O
?
show the reaction diagram
-
-
-
-
?
3-(acetamido) N,N,N-trimethylanilinium + H2O
?3-amino-N,N,N-trimethylanilinium + acetate
show the reaction diagram
-
a positively charged amide, hydrolysis by the wild-type enzyme and the mutant D70G shows a long transient phase preceeding the steady state, hysteretic burst induction phase, overview
-
-
?
3-nitroacetanilide + H2O
3-nitroaniline + acetate
show the reaction diagram
-
a neutral amide
-
-
?
7-ethyl-10-[4-(1-piperidine)-1-piperidino]carbonyloxycamtothecin + H2O
7-ethyl-10-hydroxycamptothecin + ?
show the reaction diagram
Q9N1N9
anticancer drug irinotecan CPT-11
-
?
acetoacetylcholine + H2O
acetoacetate + choline
show the reaction diagram
-
-
-
-
?
acetyl choline + H2O
acetate + choline
show the reaction diagram
-
enzyme also acts on acetyl choline to a lesser extent
-
?
acetyl-beta-methylcholine
beta-methylcholine + acetate
show the reaction diagram
Pseudomonas aeruginosa, Pseudomonas aeruginosa K
-
-
-
-
?
acetyl-beta-methylcholine + H2O
acetate + beta-methylcholine
show the reaction diagram
-
poor substrate
-
-
?
acetyl-beta-methylcholine + H2O
acetate + beta-methylcholine
show the reaction diagram
-
poor substrate
-
-
?
acetyl-beta-methylcholine + H2O
acetate + beta-methylcholine
show the reaction diagram
-
acetyl-beta-methylcholine chloride
-
-
?
acetyl-beta-methylcholine + H2O
methylcholine + acetate
show the reaction diagram
-
-
-
?
acetyl-beta-methylthiocholine + H2O
acetate + beta-methylcholine
show the reaction diagram
-
-
-
-
?
acetyl-beta-methylthiocholine + H2O
beta-methylthiocholine + acetate
show the reaction diagram
-
60.7-81.4% activity compared to acetylthiocholine
-
-
?
acetyl-beta-metylthiocholine + H2O
beta-methylthiocholine + acetate
show the reaction diagram
-
75% activity compared to acetylthiocholine
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
no substrate
-
-
-
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
acetylcholine chloride
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
acetylcholine iodide
-
-
?
acetylcholine + H2O
acetate + choline
show the reaction diagram
-
acetylcholine iodide
-
-
-
acetylcholine + H2O
acetate + choline
show the reaction diagram
Pseudomonas aeruginosa K
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylsalicylic acid + H2O
acetate + salicylate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
maximal activity at 0.15 mM, inhibition at higher concentrations
-
-
-
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
acetylthiocholine iodide
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
acetylthiocholine iodide
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
acetylthiocholine iodide
-
-
-
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
ATC
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
detection using 5,5'-dithiobis(2-nitrobenzoic acid)
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
detection using 5,5'-dithiobis(2-nitrobenzoic acid)
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
Pseudomonas aeruginosa K
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
preferred substrate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
100% activity
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
increasing activity with substrates in the following order: acetylthiocholine, propionylthiocholine, butyrylthiocholine
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
preferred substrate, 100% activity
-
-
?
acetylthiocholine + H2O
?
show the reaction diagram
-
detection with 5,5-dithiobis(2-nitrobenzoic acid)
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
acetate + thiocholine iodide
show the reaction diagram
-
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine iodide + acetate
show the reaction diagram
-
-
-
?
acetylthiocholine iodide + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine iodide + H2O
?
show the reaction diagram
-
-
-
-
?
adipyldicholine + H2O
adipic acid + choline
show the reaction diagram
-
lower activity, monitoring the dicholine substrates, the monocholine intermediates, the dicarboxylic acid and choline products by mass spectrometry,
-
-
?
benzoylcholine + H2O
benzoate + choline
show the reaction diagram
-
-
-
-
?
benzoylcholine + H2O
benzoate + choline
show the reaction diagram
-
-
-
-
?
benzoylcholine + H2O
benzoate + choline
show the reaction diagram
-
-
-
-
?
benzoylcholine + H2O
benzoate + choline
show the reaction diagram
-
poor substrate
-
-
?
benzoylcholine + H2O
benzoate + choline
show the reaction diagram
-
atypical and usual enzyme
-
-
?
benzoylcholine + H2O
benzoate + choline
show the reaction diagram
-
benzoylcholine chloride
-
-
?
benzoylcholine + H2O
benzoate + choline
show the reaction diagram
-
benzoylcholine chloride
-
-
?
benzoylcholine + H2O
benzoate + choline
show the reaction diagram
-
most specific substrate
-
-
?
benzoylcholine + H2O
choline + benzoate
show the reaction diagram
-
-
-
?
benzoylcholine + H2O
choline + benzoate
show the reaction diagram
-
-
-
?
benzoylcholine + H2O
choline + benzoate
show the reaction diagram
-
-
-
?
benzoylcholine + H2O
choline + benzoate
show the reaction diagram
-
-
-
?
benzoylcholine + H2O
choline + benzoate
show the reaction diagram
-
-
-
-
?
benzoylcholine + H2O
choline + benzoate
show the reaction diagram
-
-
-
-
?
benzoylcholine + H2O
choline + benzoate
show the reaction diagram
-
-
-
?
benzoylcholine + H2O
choline + benzoate
show the reaction diagram
-
rate-limiting step for hydrolysis is deacylation, k3
-
-
?
benzoylcholine + H2O
benzoic acid + choline
show the reaction diagram
-
-
-
-
?
benzoylthiocholine + H2O
thiocholine + benzoate
show the reaction diagram
-
-
-
?
benzoylthiocholine + H2O
thiocholine + benzoate
show the reaction diagram
-
rate-limiting step for hydrolysis is acylation, k2
-
-
?
beta-hydroxybutyrylcholine + H2O
3-hydroxybutanoate + choline
show the reaction diagram
-
-
-
-
?
butyryl choline + H2O
butyrate + choline
show the reaction diagram
-
preferred substrate
-
?
butyrylcholine + H2O
butanoate + choline
show the reaction diagram
-
-
-
-
?
butyrylcholine + H2O
butanoate + choline
show the reaction diagram
-
-
-
-
?
butyrylcholine + H2O
butanoate + choline
show the reaction diagram
-
-
-
-
-
butyrylcholine + H2O
butanoate + choline
show the reaction diagram
-
-
-
-
?
butyrylcholine + H2O
butanoate + choline
show the reaction diagram
-
best substrate
-
-
?
butyrylcholine + H2O
butanoate + choline
show the reaction diagram
-
butyrylcholine chloride
-
-
?
butyrylcholine + H2O
butanoate + choline
show the reaction diagram
-
butyrylcholine iodide
-
-
?
butyrylcholine + H2O
choline + butyrate
show the reaction diagram
-
-
-
?
butyrylcholine + H2O
choline + butyrate
show the reaction diagram
-
-
-
-
?
butyrylcholine + H2O
choline + butyrate
show the reaction diagram
-
-
-
?
butyrylcholine iodide + H2O
?
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butanoate + choline
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butanoate + choline
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butanoate + choline
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butanoate + choline
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butanoate + choline
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butanoate + choline
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butanoate + choline
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butanoate + choline
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butanoate + choline
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butanoate + choline
show the reaction diagram
-
butyrylthiocholine iodide
-
-
?
butyrylthiocholine + H2O
butanoate + choline
show the reaction diagram
-
butyrylthiocholine iodide
-
-
?
butyrylthiocholine + H2O
butanoate + choline
show the reaction diagram
-
butyrylthiocholine iodide
-
-
?
butyrylthiocholine + H2O
butanoate + choline
show the reaction diagram
-
good substrate
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
BuChE activity is decreased in Alzehimer's disease patients compared to healthy persons, overview
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
detection by 5,5-dithiobis(2-nitrobenzoic acid)
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
detection using 5,5'-dithiobis(2-nitrobenzoic acid)
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
detection using 5,5'-dithiobis(2-nitrobenzoic acid)
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
detection using 5,5'-dithiobis(2-nitrobenzoic acid)
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-, P06276
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
Q9N1N9
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
low activity
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
preferred substrate
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
increasing activity with substrates in the following order: acetylthiocholine, propionylthiocholine, butyrylthiocholine
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
BuChE catalyses the hydrolysis of numerous endogenous substances, including choline esters and the growth hormone secretagogue, octanoyl ghrelin and has an important role in Alzheimers disease
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
the enzyme might be involved in slowing of neurodegeneration in Alzheimers and Parkinsons diseases, overview, substrate as butyrylthiocholine iodide
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
1.4-15.8% activity compared to acetylthiocholine
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
74% activity compared to acetylthiocholine
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
best enzyme for the wild type enzyme
-
-
?
butyrylthiocholine + H2O
?
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
?
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
?
show the reaction diagram
-
detection by 5,5-dithiobis(2-nitrobenzoic acid)
-
-
?
butyrylthiocholine chloride + H2O
?
show the reaction diagram
-
-
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine iodide + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine iodide + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine iodide + H2O
butyrate + thiocholine iodide
show the reaction diagram
-
-
-
-
-
butyrylthiocholine iodide + H2O
butyrate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
butyrylthiocholine iodide + H2O
butyrate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
butyrylthiocholine iodide + H2O
?
show the reaction diagram
-
-
-
-
?
butyrylthiocholinium chloride + H2O
?
show the reaction diagram
-
-
-
-
?
bytyrylhiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
?
cocaine + H2O
ecgonine methyl ester + benzoate
show the reaction diagram
-
-
-
-
?
cocaine + H2O
ecgonine methyl ester + benzoate
show the reaction diagram
-
cv. EC 3.1.1.1
-
-
?
cocaine + H2O
?
show the reaction diagram
-
-
-
?
cocaine + H2O
?
show the reaction diagram
-
-
-
?
crotonylcholine + H2O
crotonate + choline
show the reaction diagram
-
-
-
-
?
D-butyryl-alpha-methylcholine + H2O
butanoate + alpha-methylcholine
show the reaction diagram
-
-
-
-
?
D-butyryl-beta-methylcholine + H2O
butanoate + beta-methylcholine
show the reaction diagram
-
-
-
-
?
echothiophate + H2O
?
show the reaction diagram
-
substrate for mutant enzyme G117H
-
-
?
ethyl ([2-[bis(propan-2-yl)amino]ethyl]-sulfanyl)(methyl)phosphinate + H2O
?
show the reaction diagram
-
substrate for mutant enzyme G117H
-
-
?
ethyl n-butyrate + H2O
ethanol + n-butanoate
show the reaction diagram
-
-
-
-
-
ethyl n-butyrate + H2O
ethanol + n-butanoate
show the reaction diagram
-
poor substrate
-
-
?
heroin + H2O
?
show the reaction diagram
-
-
-
-
?
indophenyl acetate + H2O
?
show the reaction diagram
-
-
-
-
?
indophenylacetate + H2O
indophenol + acetate
show the reaction diagram
-
-
-
?
indophenylacetate + H2O
?
show the reaction diagram
-
-
-
-
?
isoamyl isovalerate + H2O
isopentanol + isopentanoate
show the reaction diagram
-
poor substrate
-
-
?
isoamyl n-butyrate + H2O
isopentanol + n-butanoate
show the reaction diagram
-
-
-
-
?
isoamyl propionate + H2O
isopentanol + propanoate
show the reaction diagram
-
-
-
-
?
isobutyl isovalerate + H2o
isobutanol + isopentanoate
show the reaction diagram
-
poor substrate
-
-
?
isobutyl n-butyrate + H2O
isobutanol + n-butanoate
show the reaction diagram
-
-
-
-
?
isobutyl propionate + H2O
isobutanol + propanoate
show the reaction diagram
-
poor substrate
-
-
?
L-butyryl-alpha-methylcholine + H2O
butanoate + alpha-methylcholine
show the reaction diagram
-
-
-
-
?
L-butyryl-beta-methylcholine + H2O
butanoate + beta-methylcholine
show the reaction diagram
-
-
-
-
?
methyl n-butyrate + H2O
methanol + n-butanoate
show the reaction diagram
-
poor substrate
-
-
?
n-amyl acetate + H2O
n-pentanol + acetate
show the reaction diagram
-
poor substrate
-
-
?
n-amyl n-butyrate + H2O
n-pentanol + n-butanoate
show the reaction diagram
-
good substrate
-
-
?
n-butyl acetate + H2O
n-butanol + acetate
show the reaction diagram
-
poor substrate
-
-
?
n-butyl n-butyrate + H2O
n-butanol + n-butanoate
show the reaction diagram
-
poor substrate
-
-
?
n-hexyl acetate + H2O
n-hexanol + acetate
show the reaction diagram
-
poor substrate
-
-
?
N-methyl-(7-dimethylcarbamoxy)quinolinium iodide + H2O
?
show the reaction diagram
-
atypical and usual enzyme
-
-
?
N-methylindoxyl acetate + H2O
N-methylindole + acetate
show the reaction diagram
-
-
-
?
O-ethyl-O-(4-nitrophenyl)-phenylphosphonothioate + H2O
?
show the reaction diagram
-
-
-
-
?
o-nitrophenylacetate + H2O
?
show the reaction diagram
-
-
-
-
?
o-nitrophenylbutyrate + H2O
o-nitrophenol + butanoate
show the reaction diagram
-
atypical and usual enzyme
-
-
?
phenyl acetate + H2O
phenol + acetate
show the reaction diagram
-
-
-
-
?
phenylthioacetate + H2O
phenol + thioacetate
show the reaction diagram
-
-
-
-
?
phenylthiopropionate + H2O
phenol + thiopropanoate
show the reaction diagram
-
-
-
-
?
propionyl choline + H2O
propionate + choline
show the reaction diagram
-
preferred substrate
-
?
propionylcholine + H2O
propanoate + choline
show the reaction diagram
-
-
-
-
?
propionylcholine + H2O
propanoate + choline
show the reaction diagram
-
good substrate
-
-
?
propionylcholine + H2O
propanoate + choline
show the reaction diagram
-
propionylcholine chloride
-
-
?
propionylcholine + H2O
propanoate + choline
show the reaction diagram
Pseudomonas aeruginosa K
-
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
-
-
-
-
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
propionylthiocholine iodide
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
propylthiocholine
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
show the reaction diagram
-
propylthiocholine
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
Q9N1N9
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
best substrate
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
increasing activity with substrates in the following order: acetylthiocholine, propionylthiocholine, butyrylthiocholine
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
40.6-43.5% activity compared to acetylthiocholine
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
80% activity compared to acetylthiocholine
-
-
?
propionylthiocholine + H2O
thiocholine + propanoate
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
?
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
?
show the reaction diagram
-
detection by 5,5-dithiobis(2-nitrobenzoic acid)
-
-
?
propionylthiocholine + H2O
thiocholine + propionoate
show the reaction diagram
-
-
-
-
?
propionylthiocholine iodide + H2O
thiocholine + propionate
show the reaction diagram
-
preferred substrate
-
-
?
S-butyrylthiocholine iodide + H2O
butyrate + thiocholine iodide
show the reaction diagram
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
sarin + H2O
?
show the reaction diagram
-
substrate for mutant enzyme G117H
-
-
?
sebacyldicholine + H2O
sebacic acid + choline
show the reaction diagram
-
high activity, monitoring the dicholine substrates, the monocholine intermediates, the dicarboxylic acid and choline products by mass spectrometry, sebacyldicholine is hydrolyzed at both choline ester sites, though hydrolysis of dicholine is faster than hydrolysis of monocholine, overview
-
-
?
succinyl dicholine dichloride + H2O
?
show the reaction diagram
-
yolk cholinesterase 1 and 2 and blood plasma cholinesterase poor substrate, liver cholinesterase 1 and 2 no substrate
-
-
?
succinylcholine + H2O
succinate + choline
show the reaction diagram
-
-
-
-
?
succinylcholine + H2O
succinate + choline
show the reaction diagram
-
succinylcholine chloride
-
-
?
succinyldithiocholine + H2O
?
show the reaction diagram
-
-
-
-
?
succinylmonocholine + H2O
succinate + choline
show the reaction diagram
-
-
-
-
?
succinylthiocholine + H2O
thiocholine + succinate
show the reaction diagram
-
-
-
?
valerylthiocholine + H2O
pentanoate + thiocholine
show the reaction diagram
-
-
-
-
?
methyl n-valerate + H2O
methanol + n-pentanoate
show the reaction diagram
-
poor substrate
-
-
?
additional information
?
-
-
-
-
-
-
additional information
?
-
-
butyryl esters are hydrolyzed at a greater rate than propionyl, pentanoyl, valeryl- or acetyl esters
-
-
-
additional information
?
-
-
substrate specificity, overview
-
-
-
additional information
?
-
-
enzyme favors the R-enantiomer
-
?
additional information
?
-
-
atypical and usual enzymes differ only in the structure of their anionic site
-
-
-
additional information
?
-
-
feline plasma contains multiple forms of the enzyme
-
-
-
additional information
?
-
-
enzyme shows a complex genetic polymorphism
-
-
-
additional information
?
-
-
enzyme occurs in multiple molecular forms
-
-
-
additional information
?
-
-
enzyme is regulated by sex hormones
-
-
-
additional information
?
-
-
enzyme exhibits an amine sensitive aryl acylamidase, AAA, and a metallocarboxypeptidase activity
-
-
-
additional information
?
-
-
different forms of enzyme, solubilized by different extraction media, are hydrosoluble, detergent-soluble and HIS-soluble
-
-
-
additional information
?
-
-
limited alpha-chymotrypsin digestion of purified enzyme exhibits cholinesterase, acryl acylamidase, and peptidase activities
-
-
-
additional information
?
-
-
human atypical butyrylcholinesterase is a variant with an aspartic acid to glycine substitution at position 70
-
-
-
additional information
?
-
-
butyrylcholine is not a physiological substrate, enzyme may replace acetylcholine esterase in hydrolysing brain acetylcholine in patients with advanced stages of Alzheimer's disease
-
?
additional information
?
-
-
causes a concentration-dependent enhancement of the catalytic activity of trypsin, may assume a regulatory role by interacting with other proteins
-
?
additional information
?
-
-
enzyme and phosphorylcholine phosphatase coordinately contribute to the breakdown of the corneal epithelial membrane upon infection
-
-
-
additional information
?
-
-
hydrolysis of benzoylcholine and its N-alkyl derivatives shows hysteretic pre-steady-state phase of induction. Hysteresis is complex and consists of lag phase superimposed on damped oscillations
-
-
-
additional information
?
-
-
no substrate: butyrylthiocholine
-
-
-
additional information
?
-
-
the oxoanion hole of enzyme can lower the energy barrier for the acetylcholine hydrolysis significantly more than that for cocaine hydrolysis
-
-
-
additional information
?
-
-
very bad substratets: butyrylcholine, succinylcholine
-
-
-
additional information
?
-
-
calcium-activated butyrylcholinesterase as a major protective mechanism against suicide inhibition of acetylcholinesterase by organophosphates in this non-neuronal tissue
-
-
-
additional information
?
-
-
inhibition of ChE is not lethal
-
-
-
additional information
?
-
-
rat plasma BuChE is increased when pretreated with horse BuChE
-
-
-
additional information
?
-
-
the enzyme is assessed as a marker for liver pathologies, patients with diminished BChE activity do not have increased BChE aryl acylamidase activity, but the overall aryl acylamidase activity is increased, overview
-
-
-
additional information
?
-
-
the enzyme is involved in the morphogenetic processes of neuronal and non-neuronal tissues
-
-
-
additional information
?
-
-
BChE also shows aryl acylamidase activity, i.e. AAA activity, the rate-determining step of which is the acylation, overview
-
-
-
additional information
?
-
-
in vitro effects of environmental contaminants on enzyme activities, overview
-
-
-
additional information
?
-
-
structure-activity relationships and kinetic studies, overview, the enzyme also shows an aryl acylamidase activity, EC 3.5.1.13, whereby it catalyzes the hydrolysis of amides of certain aromatic amines, BuChE shows high activity with larger N-(2-nitrophenyl)alkylamides, the ester and anilide substrates compete for the some catalytic site, no significant hydrolysis of the anilide takes place until the preferred choline ester hydrolysis is completed, overview
-
-
-
additional information
?
-
-
tissue specificity of enzyme activities with different substrates, overview
-
-
-
additional information
?
-
-
BChE tetramers from human plasma are associated with proline-rich peptides derived froma cytoplasmic protein, lamellipodin or RAPH1. BChE does exert a toxic effect on cultured neurons
-
-
-
additional information
?
-
-
butyrylcholinesterase is important in human cocaine metabolism despite its limited ability to hydrolyze this drug, it is a major contributor to cocaine metabolism and detoxification
-
-
-
additional information
?
-
-
butyrylcholinesterase to acetylcholinesterase ratio in mouse sera decreases from 6:1 in wild-type control to 3:1 in mdx-mice
-
-
-
additional information
?
-
-
embryonic butyrylcholinesterase is typically found in cells engaged in proliferation processes
-
-
-
additional information
?
-
-
hBChE is primarily involved in neuronal transmission and is a potential bioscavenger of toxic organophosphates to protect acetylcholinesterase
-
-
-
additional information
?
-
-
inhibition of BChE, along with the acetylcholinesterase, and restoration of acetylcholine is a therapeutic strategy in treatment of Alzheimer's disease and other forms of dementia
-
-
-
additional information
?
-
-
relationship between K variant of gene BCHE genotype and butyrylcholinesterase activity in autopsy brain tissue, BuChE activity in temporal cortex is 37% higher in K homozygotes than in wild-type homozygotes, overview
-
-
-
additional information
?
-
-
the butyrylcholinesterase detoxifies racemic soman, but to a lower rate and less enantioselective than acetylcholinesterase, EC 3.1.1.7, overview
-
-
-
additional information
?
-
-
the enzyme participates in neurogenesis and neurite growth in neurons and glia, and prolongates the ThT lag time and reduces the apparent rate of beta-amyloid-fibril formation compared to beta-amyloid alone
-
-
-
additional information
?
-
-
BuChE reacts stoichiometrically with organophosphosphorus esters, overview
-
-
-
additional information
?
-
-
butyrylcholinesterase hydrolyzes long chain dicholine esters more rapidly than short chain dicholine esters. The active site of butyrylcholinesterase contains the catalytic residue Ser198 and is deeply buried within the enzyme molecule and there is limited space for binding of large compounds, three-step binding model for hydrolysis of positively charged substrates by BuChE, overview
-
-
-
additional information
?
-
-
hydrolysis of diverse esters and thioesters with various structures of alkyl bridge between esteric atom and ammonium grouping with common formula R1-(O)-X-CHR2-CHR3-C, and of acylates and thioacylates of ammonium derivatives with common formula R1-(O)-X-R2, and of acetates and thioacetates with various structures of ammonium grouping with common formula CH3C(O)-X-CH2CH2-R, overview
-
-
-
additional information
?
-
-
in addition to the hydrolysis of acetylcholine and other esters, acetylcholinesterase and BChE hydrolyze arylacylamides, although at a much lower rate
-
-
-
additional information
?
-
-
the enzyme shows in addition to its esterase activity also aryl acylamidase activity, EC 3.5.1.13, hydrolyzing 2-nitroacetanilide and its trifluoro-derivative, the ratio of the two activities depends on the tissue source and oligomeric state of the enzyme, the aryl acylamidase activity is low for tetramers, but increased for monomeric enzyme, overview
-
-
-
additional information
?
-
Pseudomonas aeruginosa K
-
very bad substratets: butyrylcholine, succinylcholine
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylsalicylic acid + H2O
acetate + salicylate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
benzoylcholine + H2O
benzoic acid + choline
show the reaction diagram
-
-
-
-
?
butyrylcholine + H2O
choline + butyrate
show the reaction diagram
-
-
-
?
butyrylcholine + H2O
choline + butyrate
show the reaction diagram
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
show the reaction diagram
-
BuChE activity is decreased in Alzehimer's disease patients compared to healthy persons, overview
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
BuChE catalyses the hydrolysis of numerous endogenous substances, including choline esters and the growth hormone secretagogue, octanoyl ghrelin and has an important role in Alzheimers disease
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
show the reaction diagram
-
the enzyme might be involved in slowing of neurodegeneration in Alzheimers and Parkinsons diseases, overview
-
-
?
cocaine + H2O
ecgonine methyl ester + benzoate
show the reaction diagram
-
-
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
show the reaction diagram
-
-
-
-
?
heroin + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
atypical and usual enzymes differ only in the structure of their anionic site
-
-
-
additional information
?
-
-
feline plasma contains multiple forms of the enzyme
-
-
-
additional information
?
-
-
enzyme shows a complex genetic polymorphism
-
-
-
additional information
?
-
-
enzyme occurs in multiple molecular forms
-
-
-
additional information
?
-
-
enzyme is regulated by sex hormones
-
-
-
additional information
?
-
-
enzyme exhibits an amine sensitive aryl acylamidase, AAA, and a metallocarboxypeptidase activity
-
-
-
additional information
?
-
-
different forms of enzyme, solubilized by different extraction media, are hydrosoluble, detergent-soluble and HIS-soluble
-
-
-
additional information
?
-
-
limited alpha-chymotrypsin digestion of purified enzyme exhibits cholinesterase, acryl acylamidase, and peptidase activities
-
-
-
additional information
?
-
-
human atypical butyrylcholinesterase is a variant with an aspartic acid to glycine substitution at position 70
-
-
-
additional information
?
-
-
butyrylcholine is not a physiological substrate, enzyme may replace acetylcholine esterase in hydrolysing brain acetylcholine in patients with advanced stages of Alzheimer's disease
-
?
additional information
?
-
-
causes a concentration-dependent enhancement of the catalytic activity of trypsin, may assume a regulatory role by interacting with other proteins
-
?
additional information
?
-
-
enzyme and phosphorylcholine phosphatase coordinately contribute to the breakdown of the corneal epithelial membrane upon infection
-
-
-
additional information
?
-
-
calcium-activated butyrylcholinesterase as a major protective mechanism against suicide inhibition of acetylcholinesterase by organophosphates in this non-neuronal tissue
-
-
-
additional information
?
-
-
inhibition of ChE is not lethal
-
-
-
additional information
?
-
-
rat plasma BuChE is increased when pretreated with horse BuChE
-
-
-
additional information
?
-
-
the enzyme is assessed as a marker for liver pathologies, patients with diminished BChE activity do not have increased BChE aryl acylamidase activity, but the overall aryl acylamidase activity is increased, overview
-
-
-
additional information
?
-
-
the enzyme is involved in the morphogenetic processes of neuronal and non-neuronal tissues
-
-
-
additional information
?
-
-
BChE tetramers from human plasma are associated with proline-rich peptides derived froma cytoplasmic protein, lamellipodin or RAPH1. BChE does exert a toxic effect on cultured neurons
-
-
-
additional information
?
-
-
butyrylcholinesterase is important in human cocaine metabolism despite its limited ability to hydrolyze this drug, it is a major contributor to cocaine metabolism and detoxification
-
-
-
additional information
?
-
-
butyrylcholinesterase to acetylcholinesterase ratio in mouse sera decreases from 6:1 in wild-type control to 3:1 in mdx-mice
-
-
-
additional information
?
-
-
embryonic butyrylcholinesterase is typically found in cells engaged in proliferation processes
-
-
-
additional information
?
-
-
hBChE is primarily involved in neuronal transmission and is a potential bioscavenger of toxic organophosphates to protect acetylcholinesterase
-
-
-
additional information
?
-
-
inhibition of BChE, along with the acetylcholinesterase, and restoration of acetylcholine is a therapeutic strategy in treatment of Alzheimer's disease and other forms of dementia
-
-
-
additional information
?
-
-
relationship between K variant of gene BCHE genotype and butyrylcholinesterase activity in autopsy brain tissue, BuChE activity in temporal cortex is 37% higher in K homozygotes than in wild-type homozygotes, overview
-
-
-
additional information
?
-
-
the butyrylcholinesterase detoxifies racemic soman, but to a lower rate and less enantioselective than acetylcholinesterase, EC 3.1.1.7, overview
-
-
-
additional information
?
-
-
the enzyme participates in neurogenesis and neurite growth in neurons and glia, and prolongates the ThT lag time and reduces the apparent rate of beta-amyloid-fibril formation compared to beta-amyloid alone
-
-
-
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Ba2+
-
activates
Ca2+
-
activates 9fold at 0.5 mM with substrate O-ethyl-O-(4-nitrophenyl)-phenylphosphonothioate via a specific EF-hand calcium binding site, molecular modelling of Ca2+ binding to EF-hands, disruption by H2O2-mediated oxidation
Mg2+
-
20 mM activates
Zn2+
-
1-2 mM, 10% activation, inhibitory above
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
(+)-7-deoxy-O6-buxafurandiene
-
isolated from Buxus hyrcana
(+)-benzoylbuxidienine
-
isolated from Buxus hyrcana
(+)-buxapapillinine
-
isolated from Buxus hyrcana
(+)-buxaquamarine
-
isolated from Buxus hyrcana
(+)-cocaine
-
-
(+)-debromoflustramine B
-
-
(+)-irehine
-
isolated from Buxus hyrcana
(+)-limonene
-
identified compound of Pimpinella anisodes, IC50: 456.2 microgram/ml
(+)-O6-buxafurandiene
-
isolated from Buxus hyrcana
(+)-sabinene
-
identified compound of Pimpinella anisodes, IC50: 218.6 microgram/ml
(-)-10,10-dimethylhuperzine A
-
-
(-)-3-O-acetyl-spectaline
-
isolated from flowers of Senna spectabilis
(-)-Carvone
-
62.4% inhibition at 1 mM
(-)-cocaine
-
-
(-)-debromoflustramine B
-
-
(-)-galanthamine
-
isolated from Galanthus woronowii
(-)-N1-phenethylnorcymserine
-
-
-
(-)-N1-phenethylnorphenserine
-
-
-
(-)-N1-phenethylnorphysostigmine
-
-
-
(-)-phenserine
-
-
(-)-spectaline
-
isolated from flowers of Senna spectabilis
(13E,13'Z)-N,N'-hexane-1,6-diylbis(6,7,8,9,10,11-hexahydro-13H-azocino[2,1-b]quinazolin-13-imine)
-
-
(13Z,13'Z)-N,N'-heptane-1,7-diylbis(6,7,8,9,10,11-hexahydro-13H-azocino[2,1-b]quinazolin-13-imine)
-
-
(1alpha,3beta,22R)-stigmast-5-ene-1,3,22-triol
-
i.e. haloxysterol A, isolated from Haloxylon recurvum
(1alpha,3beta,22R)-stigmasta-4,6-diene-1,3,22-triol
-
i.e. haloxysterol B, isolated from Haloxylon recurvum
(1alpha,3beta,5alpha,6beta,22R)-stigmastane-1,3,5,6,22-pentol
-
i.e. haloxysterol D, isolated from Haloxylon recurvum
(1S,2S,11bS)-4-[2-(acetyloxy)ethyl]-5-methyl-1,2,3,4,4a,5,6,11b-octahydro[1,3]dioxolo[4,5-j]phenanthridine-1,2-diyl diacetate
-
-
(1S,2S,11bS)-4-[2-(acetyloxy)ethyl]-5-methyl-1,2,4a,5,6,11b-hexahydro[1,3]dioxolo[4,5-j]phenanthridine-1,2-diyl diacetate
-
-
(2,6,6-trimethylcyclohex-1-en-1-yl)methyl 6-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
-
-
(2-mercaptoethyl)trimethylammonium iodide O,O-diethyl phosphorothioate
-
0.2 mM, 21% inhibition; i.e. echothiophate
-
(22R)-22-hydroxystigmasta-4,9(11)-dien-3-one
-
i.e. haloxysterol , isolated from Haloxylon recurvum
(24S)-ethylcholesta-7,9(11),22(E)-triene-3beta-ol
-
isolated from Haloxylon recurvum
(2E)-1,3-diphenylprop-2-en-1-one
-
-
(2E)-1-(5-chloro-2-hydroxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one
-
-
(2E)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(3,4-dimethoxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(3-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2x)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-([[(2E)-3-phenylprop-2-enoyl]oxy]carbonyl)-D-arabino-hexitol
-
96% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(2-methylbutanoyl)-D-arabino-hexitol
-
99% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(biphenyl-4-ylcarbonyl)-D-arabino-hexitol
-
99% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(carboxycarbamoyl)-D-arabino-hexitol
-
92% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(cyclopentylcarbonyl)-D-arabino-hexitol
-
99% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(cyclopropylcarbonyl)-D-arabino-hexitol
-
97% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(phenoxycarbonyl)-D-arabino-hexitol
-
99% inhibition at 0.1 mM, highly selective for BuChE, with about 50000fold selectivity over human erythrocyte acetylcholinesterase. Competitive, and slowly reversible inhibition by active site carbamylation
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-([[(4-methylphenyl)sulfonyl]oxy]carbonyl)-D-arabino-hexitol
-
25% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-([[(trifluoromethyl)sulfonyl]oxy]carbonyl)-D-arabino-hexitol
-
85% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[(2H-chromen-2-yloxy)carbonyl]-D-arabino-hexitol
-
100% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[(3,4-dihydroxyphenyl)carbonyl]-D-arabino-hexitol
-
38% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[(pentanoyloxy)carbonyl]-D-arabino-hexitol
-
95% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[(propanoyloxy)carbonyl]-D-arabino-hexitol
-
97% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[([[4-(heptyloxy)phenyl]carbonyl]oxy)carbonyl]-D-arabino-hexitol
-
80% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[[(methylsulfonyl)oxy]carbonyl]-D-arabino-hexitol
-
9.8% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[[(naphthalen-2-ylcarbonyl)oxy]carbonyl]-D-arabino-hexitol
-
100% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[[(pyridin-3-ylcarbonyl)oxy]carbonyl]-D-arabino-hexitol
-
99% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[[(pyridin-4-ylcarbonyl)oxy]carbonyl]-D-arabino-hexitol
-
97% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-([2-[(carbamoyloxy)methyl]-5-hydroxybenzyl]carbamoyl)-D-arabino-hexitol
-
95% inhibition at 0.1 mM
(2xi)-5-O-[(acetyloxy)carbonyl]-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-D-arabino-hexitol
-
97% inhibition at 0.1 mM
(3,4-dimethoxyphenyl)(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methanol
-
-
(3,4-dimethoxyphenyl)-(4-([(2-dimethylaminoethyl)-methylamino]methyl)phenyl)-methanone
-
-
(3,4-dimethoxyphenyl)-(4-([(2-methoxybenzyl)methylamino]methyl)phenyl)-methanone
-
-
(3,4-dimethoxyphenyl)-(4-([methyl-(3-methylbenzyl)amino]methyl)phenyl)methanone
-
-
(3,4-dimethoxyphenyl)-(4-([methyl-(3-nitrobenzyl)amino]methyl)phenyl)methanone
-
-
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl (2-methylphenyl)carbamate
-
50% inhibition at 1950 nM
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 50 nM
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl ethylcarbamate
-
50% inhibition at 4 nM
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl methylcarbamate
-
50% inhibition at 16 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl (2-methylphenyl)carbamate
-
50% inhibition at 1560 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 17 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl ethylcarbamate
-
50% inhibition at 2 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl methylcarbamate
-
50% inhibition at 4 nM
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2-phenylethyl)carbamate
-
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3,4-dimethoxyphenyl)carbamate
-
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-acetylphenyl)carbamate
-
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-butylphenyl)carbamate
-
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-chlorophenyl)carbamate
-
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-methoxyphenyl)carbamate
-
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-nitrophenyl)carbamate
-
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-phenoxyphenyl)carbamate
-
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-tert-butylphenyl)carbamate
-
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (cyclohexylmethyl)carbamate
-
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl 1,3-benzodioxol-5-ylcarbamate
-
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl benzylcarbamate
-
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl biphenyl-4-ylcarbamate
-
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl cyclohexylcarbamate
-
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl hexylcarbamate
-
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl naphthalen-2-ylcarbamate
-
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl [4-(dimethylamino)phenyl]carbamate
-
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl [4-(hexyloxy)phenyl]carbamate
-
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,3-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,4,6-trimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,4-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,5-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,6-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2-ethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3,4-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3-methylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-methylphenyl)carbamate
-
-
(3beta,4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,28-dihydroxy-3-methoxy-1,26-dioxo-5,6:22,26-diepoxyergost-24-en-19-oic acid
-
isolated from Withania somnifera, noncompetitive inhibition
(3beta,4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,28-dihydroxy-3-methoxy-5,6:22,26-diepoxyergost-24-ene-1,26-dione
-
isolated from Withania somnifera, noncompetitive inhibition
(3beta,4beta,6beta,8xi,9xi,14xi,17xi,22R)-4,6,27-trihydroxy-3-methoxy-22,26-epoxyergost-24-ene-1,26-dione
-
isolated from Withania somnifera, noncompetitive inhibition
(3E)-3-([4-[2-(diethylamino)ethoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-([4-[3-(diethylamino)propoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-[(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-[(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3R,4aS,9bS)-9-(chloromethyl)-9b-[2-[(ethoxycarbonyl)(methyl)amino]ethyl]-6-methoxy-3,4,4a,9b-tetrahydrodibenzo[b,d]furan-3-yl ethyl carbonate
-
-
(4-([benzyl-(2-dimethylaminoethyl)amino]methyl)-phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-([benzyl-(2-hydroxyethyl)amino]methyl)phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-[(benzylethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)-(3-fluoro-4-methoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)-(4-methoxyphenyl)methanone
-
-
(4-[3-(benzylmethylamino)propenyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4aS,6R,8aS)-3-methoxy-11-methyl-5,6,10,11,13,14-hexahydro-4aH,9H-[1]benzofuro[3a,3,2-gh][3,4]benzoxazonin-6-ol
-
-
(4aS,6R,8aS)-3-methoxy-11-[8-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]octyl]-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol
-
-
(4aS,6R,8aS)-3-[[12-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)dodecyl]oxy]-6-hydroxy-11-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-3-[[8-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]oxy]-6-hydroxy-11-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-[10-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]decyl]-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-[8-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]octyl]-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methyl-11-(10-phenyldecyl)-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methyl-11-(8-phenyloctyl)-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,27-dihydroxy-5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione
-
isolated from Ajuga bracteosa, noncompetitive inhibition
(5alpha,6alpha,7alpha,8xi,9xi,14xi,17xi,22R)-5-hydroxy-20-methyl-6,7:22,26-diepoxyergosta-2,24-diene-1,26-dione
-
isolated from Ajuga bracteosa, noncompetitive inhibition
(6,7-dimethoxyisoquinolin-1-yl)(2-methoxyphenyl)methanol
-
-
(6,7-dimethoxyisoquinolin-1-yl)(3,4-dimethoxyphenyl)methanol
-
-
(6,7-dimethoxyisoquinolin-1-yl)(3,4-dimethoxyphenyl)methanone
-
-
(8Z)-5,6-dihydro-8H-isoquino[1,2b]quinazolin-8-imine
-
-
(9E,9'E)-N,N'-hexane-1,6-diylbis(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-imine)
-
-
(9E,9'Z)-N,N'-heptane-1,7-diylbis(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-imine)
-
-
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
E2020, acetylcholinesterase inhibitor used in treatment of Alzheimer's disease, interacts with the active site and the peripheral anionic site of the enzyme
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
E2020, acetylcholinesterase inhibitor used in treatment of Alzheimer's diaease, inhibition kinetics
(S)-3-benzoyloxy-1-benzylquinuclidinium bromide
-
inhibition at 0.01 mM and 0.02 mM
(Z)-N1-methyl-N4-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylidene)-N1-(3-((E)-8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)-butane-1,4-diamine
-
-
-
1,1'-(2E)-but-2-ene-1,4-diyldipyridinium dibromide
-
-
1,1'-(2Z)-but-2-ene-1,4-diyldipyridinium dichloride
-
-
1,1'-(benzene-1,2-diyldimethanediyl)dipyridinium dibromide
-
-
1,1'-(benzene-1,3-diyldimethanediyl)dipyridinium dibromide
-
-
1,1'-(benzene-1,4-diyldimethanediyl)dipyridinium dibromide
-
-
1,1'-(naphthalene-2,7-diyldimethanediyl)dipyridinium dibromide
-
-
1,1'-(oxydiethane-2,1-diyl)dipyridinium dibromide
-
-
1,1'-(oxydimethanediyl)dipyridinium dichloride
-
-
1,1'-butane-1,4-diyldipyridinium dibromide
-
-
1,1'-decane-1,10-diyldipyridinium dibromide
-
-
1,1'-heptane-1,7-diyldipyridinium dibromide
-
-
1,1'-hexane-1,6-diyldipyridinium dibromide
-
-
1,1'-nonane-1,9-diyldipyridinium dibromide
-
-
1,1'-octane-1,8-diyldipyridinium dibromide
-
-
1,1'-pentane-1,5-diyldipyridinium dibromide
-
-
1,1'-undecane-1,11-diyldipyridinium dibromide
-
-
1,2,11,12-tetramethoxy-7-methyl-5,6-dihydro-4H,8H-pyrido[3,2,1-de]phenanthridinium
-
-
1,2,3,10,11-pentamethoxy-7-(methoxycarbonyl)-5,6-dihydro-4H,8H-pyrido[3,2,1-de]phenanthridinium
-
-
1,2,3,4,9,9a-hexahydroacridin-9-amine
-
-
1,2-di(berberine-9-O-yl)ethane dibromide
-
-
-
1,2-diacetyllycorine
-
-
1,3-di(berberine-9-O-yl)ethane dibromide
-
-
-
1,3a,8-tris(3-methylbut-2-enyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
-
-
1,4-dichlorobenzene
-
reversible
1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-nitro-D-threo-hexitol
-
96% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-(butylcarbamoyl)-5-O-nitro-D-threo-hexitol
-
92% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-(cyclohexylcarbamoyl)-5-O-nitro-D-threo-hexitol
-
99% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-(ethylcarbamoyl)-5-O-nitro-D-threo-hexitol
-
73% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-(methylcarbamoyl)-5-O-nitro-D-threo-hexitol
-
82% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-nitro-5-O-(phenylcarbamoyl)-D-threo-hexitol
-
37% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-nitro-5-O-(propylcarbamoyl)-D-threo-hexitol
-
93% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-nitro-5-O-[[4-(trifluoromethyl)phenyl]carbamoyl]-D-threo-hexitol
-
10% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-[(2-chlorophenyl)carbamoyl]-5-O-nitro-D-threo-hexitol
-
11% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-[(3,4-dichlorophenyl)carbamoyl]-5-O-nitro-D-threo-hexitol
-
28% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-[(3-chlorophenyl)carbamoyl]-5-O-nitro-D-threo-hexitol
-
11% inhibition at 0.1 mM
1,5,6-trimethyl-9-oxo-7H,9H-pyrano[3,4,5-ij]isoquinolin-1-ium
-
-
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one
-
1 mM, 20% inhibition, 10 mM, 65% inhibition; i.e. B.W 284 C51 dibromide
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one
-
1 mM, 12% inhibition; i.e. B.W 284 C51 dibromide
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one
-
i.e. B.W 284 C51 dibromide
1,5-bis-(4-allyldimethyl-ammoniumphenyl)-pentan-3-one dibromide
-
i.e. BW284c51, cholinesterase from male fish is more sensitive to inhibition
1,8-cineole
-
isolated from Melaleuca atlernifolia
1,8-cineole
-
48.2% inhibition at 1 mM
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
-
-
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methylisoquinolinium
-
-
1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline
-
-
1-(hydroxymethyl)-5-methyloctahydro-2H-quinolizinium
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
1-(hydroxymethyl)-5-methyloctahydro-2H-quinolizinium
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
1-benzyl-5-methoxy-3a,8-bis(3-methylbut-2-enyl)-1,2,3,3a,8,8ahexahydropyrrolo[2,3-b]indole
-
-
1-dehydrotestosterone
-
-
1-epideacetylbowdensine
-
-
1-methyl-1-[2-oxo-3-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)propyl]pyrrolidinium
-
-
1-methyl-1-[3-oxo-4-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)butyl]pyrrolidinium
-
-
1-methyl-1-[4-oxo-5-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)pentyl]pyrrolidinium
-
-
1-methyl-3-(3-(methylamino)cyclohexyl)pyridinium
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
1-methyl-3-(3-(methylamino)cyclohexyl)pyridinium
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
1-methyl-4,5-dihydro[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-6-ium-2-olate
-
-
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl (2-methylphenyl)carbamate
-
50% inhibition above 0.030 mM
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 22 nM
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl ethylcarbamate
-
50% inhibition at 24 nM
1-methylcarbamoyloxy-naphthalene
-
0.2 mM, 19% inhibition; i.e. sevin
1-naphthyl methyl carbamate
-
the effects of sublethal concentrations of 1-naphthyl methyl carbamate on the ChE activities present in the oligochaete Lumbriculus variegatus and in the pigmented Biomphalaria glabrata gastropod are investigated. ChE activity from both species are inhibited, with EC50 and IC50 values 20times lower for the oligochaete than for the gastropod the recovery process in uncontaminated media is more efficient in oligochaetes than in snails. In 2 h the oligochaetes show no inhibition with respect to control values whereas the snails do not reach control values even after 48 h of being in pesticide-free water
1-naphthyl phenothiazine carbamate
-
-
1-p-menthanol, 2-dimethylamino-, 2,5-dimethylbenzyl chloride
-
Q 80, growth retardant, 0.1 mM, 32% inhibition
10-(2,2-dimethylpropanoyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC 3.1.1.7 is 4.7
10-(2-ethylbutanoyl)-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-(3,3-dimethylbutanoyl)-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-(3-methylbutanoyl)-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-(chloroacetyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC 3.1.1.7 is 7.3
10-(cyclobutylcarbonyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC 3.1.1.7 is 11.6
10-(cycloheptylcarbonyl)-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-(cyclohexylacetyl)-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-(cyclohexylcarbonyl)-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-(cyclopentylacetyl)-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-(cyclopentylcarbonyl)-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-(cyclopropylcarbonyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC 3.1.1.7 is 1.9
10-(methoxyacetyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC 3.1.1.7 is 0.8
10-acetyl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC 3.1.1.7 is 1.1
10-butyryl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC 3.1.1.7 is 1.9
10-heptanoyl-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-hexanoyl-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-isobutyryl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC 3.1.1.7 is 2.7
10-methoxy-9-(4-phenoxybutoxy)-5,6-dihydro[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium bromide
-
-
10-N-demethyl-10-N-(10-(4-(piperidin-1-ylmethyl)-phenoxy)decan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(12-(4-(piperidin-1-ylmethyl)-phenoxy)dodecan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(2-(4-(piperidin-1-ylmethyl)phenoxy)ethan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(3-(4-(piperidin-1-ylmethyl)phenoxy)propan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(1-benzylpiperidin-4-yloxy)-butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(3-(1-morpholinoethyl)phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-((diethylamino)methyl)-phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-(morpholinomethyl)phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-(piperidin-1-ylmethyl)phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-(pyrrolidine-1-carbonyl)-phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(5-(4-(piperidin-1-ylmethyl)phenoxy)pentan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(1-benzylpiperidin-4-yloxy)-hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(3-(1-morpholinoethyl)phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-((diethylamino)methyl)-phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-(morpholinomethyl)phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-(piperidin-1-ylmethyl)phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-(pyrrolidine-1-carbonyl)-phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(8-(4-(piperidin-1-ylmethyl)phenoxy)octan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(9-(4-(piperidin-1-ylmethyl)phenoxy)nonan-1-yl)-galanthamine
-
-
10-pentanoyl-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-propionyl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC 3.1.1.7 is 1.8
10-[4-[(diethylamino)methyl]phenoxy]-N,N-diethyldecan-1-amine
-
-
10-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropyldecan-1-amine
-
-
11alpha,17beta-dihydroxyandrost-1,4-dien-3-one
-
-
11alpha-hydroxyandrost-1,4-dien-3,17-dione
-
-
11alpha-hydroxyandrost-4-en-3,17-dione
-
-
11alpha-hydroxytestolactone
-
-
11alpha-hydroxytestosterone
-
-
12-n-butoxy-demethoxykesselringine
-
-
13-methyl-5,8-dihydro-6H isoquino[1,2b]quinazolin-13-ium chloride
-
-
13-methyl-5,8-dihydro-6H-isoquino[1,2b]quinazolin-13-ium chloride
-
-
14-ethoxy-14-oxogalanthamine
-
-
15alpha,16alpha-epoxy-17-hydroxy-ent-kauran-19-oic acid
-
-
16 alpha-hydroxy-17-isovaleroyloxy-ent-kauran-19-oic acid
-
-
16alpha,17-dihydroxy-ent-kauran-19-oic acid
-
-
17-hydroxy-ent-kaur-15-en-19-oic acid
-
-
17beta-hydroxy-5alpha-androstan-3,6-dione
-
-
18-nor-ent-Kaur-16-ene-4 beta-ol
-
-
18-nor-ent-pimara-8(14),15-diene-4 beta-ol
-
-
19,20-dihydroervahanin A
-
-
19,20-dihydrotabernamine
-
-
2'-ethylphenylgeneserine N-oxide
-
50% inhibition at 1700 nM
2,2,-dichlorvinyl dimethyl phosphate
-
irreversible inhibition
-
2,2-dichlorovinyl dimethyl phosphate
-
i.e. DDVP, reversible, detailed kinetic analysis and comparison with acetylcholinesterase EC 3.1.1.7
2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
2,3-dimethoxy-6-methyl-9H-xanthen-9-one
-
-
2-((Z)-(hydroxyimino)methyl)-1-methylpyridinium chloride
-
i.e. 2-PAM, reversible, detailed kinetic analysis and comparison with acetylcholinesterase EC 3.1.1.7
2-(1-piperidinyl)ethyl phenothiazine carbamate
-
-
2-(1-pyrrolidinyl)ethyl phenothiazine carbamate
-
-
2-(3-methylphenyl)-4H-chromen-4-one
-
-
2-(4-(((7-(diethylamino)-2,4-dioxo-2H-chromen-3(4H)-ylidene)methyl)amino)phenyl)-N'-1,2,3,4-tetrahydroacridin-9-ylacetohydrazide
-
-
2-(4-methylphenyl)-4H-chromen-4-one
-
-
2-(4-morpholino)ethyl phenothiazine carbamate
-
-
2-(6-oxo-7,11-diazatricyclo(7.3.1.0 2,7)tridec-11-yl)ethyl acetate
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
2-(6-oxo-7,11-diazatricyclo(7.3.1.0 2,7)tridec-11-yl)ethyl acetate
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
2-(benzylaminocarbonyloxy)-5-(phenylcarbonyloxyimino-)-1,4 3,6-dianhydro-D-glucitol
-
9% inhibition at 0.1 mM
2-(benzylaminocarbonyloxy)-5-deoxy, 5-dehydro-((ethyloxycarbonyl)ene-)-1,4 3,6-dianhydro-D-glucitol
-
4.9% inhibition at 0.1 mM
2-(benzylaminocarbonyloxy)-5-deoxy-5-phenylcarbonylamino-1,4 3,6-dianhydro-D-glucitol
-
46% inhibition at 0.1 mM
2-(benzylaminocarbonyloxy)-5-deoxy-L-xylohex-6-enitol
-
9.8% inhibition at 0.1 mM
2-(benzylaminocarbonyloxy)-5-keto-1,4 3,6-dianhydro-D-glucitol
-
10% inhibition at 0.1 mM
2-(benzylaminocarbonyloxy)-5-ketoxime-1,4 3,6-dianhydro-D-glucitol
-
83% inhibition at 0.1 mM
2-(benzylaminocarbonyloxy)-5-O-(phenylpropyloxy)-1,4 3,6-dianhydro-D-glucitol
-
55% inhibition at 0.1 mM
2-(benzylaminocarbonyloxy)-5-O-benzyl-1,4 3,6-dianhydro-D-glucitol
-
55% inhibition at 0.1 mM
2-(benzylaminocarbonyloxy-)-5-O-(1-naphthoyl)-1,4:3,6-dianhydro-D-glucitol
-
99% inhibition at 0.1 mM
2-(diethylamino)ethyl 10H-phenothiazine-10-carboxylate
-
-
2-(dimethylamino)ethyl (2Z)-2-[[(2-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoate
-
-
2-(dimethylamino)ethyl (2Z)-2-[[(2-chlorophenyl)carbonyl]amino]-3-phenylprop-2-enoate
-
-
2-(dimethylamino)ethyl (2Z)-2-[[(2-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoate
-
-
2-(dimethylamino)ethyl (2Z)-2-[[(3-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoate
-
-
2-(dimethylamino)ethyl (2Z)-2-[[(4-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoate
-
-
2-(dimethylamino)ethyl (2Z)-2-[[(4-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoate
-
-
2-(dimethylamino)ethyl (2Z)-3-phenyl-2-[(phenylcarbonyl)amino]prop-2-enoate
-
-
2-(dimethylamino)ethyl 10H-phenothiazine-10-carboxylate
-
-
2-(trifluoromethyl)phenyl butylcarbamate
-
-
2-acetamido-N-(4-(8,9,10,11-tetrahydro-6H-azocino-[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,-11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)acetamide
-
-
-
2-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
-
2-chlorophenyl 1-methylhydrazinecarboxylate
-
-
2-chlorophenyl butylcarbamate
-
-
2-chlorophenyl phenothiazine carbamate
-
-
2-decanol
-
42,0% inhibition at 1 mM
2-dimethylaminoethyl esters of N-substituted alpha,beta-dehydrophenylalanine
-
inhibition potencies, overview
-
2-ethylphenyl butylcarbamate
-
-
2-methoxyphenyl butylcarbamate
-
-
2-methoxyphenyl phenothiazine carbamate
-
-
2-methylphenyl butylcarbamate
-
-
2-methylphenyl phenothiazine carbamate
-
-
2-naphthyl phenothiazine carbamate
-
-
2-nitrophenyl butylcarbamate
-
-
2-t-butylphenyl phenothiazine carbamate
-
-
2-tert-butoxyphenyl butylcarbamate
-
-
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
-
-
2-[cyano(3-indolyl)methylene]-3-indolone
-
an alkaloid isolated from Isatis tinctoria
2-[[(2Z)-2-[[(2-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
-
-
2-[[(2Z)-2-[[(2-chlorophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
-
-
2-[[(2Z)-2-[[(2-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium
-
i.e. compound IIIf, a choline ester of dehydrophenylalanine, the amine group of the amino acid is derivatized with a benzoyl group containing a methoxy in the 2-position, binding structure and modelling, overview
2-[[(2Z)-2-[[(2-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
-
-
2-[[(2Z)-2-[[(3-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
-
-
2-[[(2Z)-2-[[(4-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
-
-
2-[[(2Z)-2-[[(4-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
-
-
2-[[2-[(5aS,7R,9aS)-1-formyl-7-hydroxy-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl](methyl)amino]butanoic acid
-
-
2-[[2-[(5aS,7R,9aS)-7-hydroxy-1-(hydroxymethyl)-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl](methyl)amino]butanoic acid
-
-
24-ethyl-cholest-7-ene-3,5,6-triol
-
isolated from Haloxylon recurvum
24-ethylcholest-6-ene-3,5-diol
-
isolated from Haloxylon recurvum
2alpha,11alpha-dihydroxyfawcettiine
-
-
2beta-hydroxyepipachysamine D
-
-
3'-hydroxyepiglucoisatisin
-
an alkaloid isolated from Isatis tinctoria
3,3'-((1,5-dioxopentane-1,5-diyl)bis(iminocyclohexane-3,1-diyl))bis(1-methylpyridinium)
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
3,3'-((1,5-dioxopentane-1,5-diyl)bis(iminocyclohexane-3,1-diyl))bis(1-methylpyridinium)
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
3,3'-[butane-1,4-diylbis(oxy)]bis(5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinoline)
-
-
3,3'-[butane-1,4-diylbis(oxy)]bis(7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine)
-
-
3,3'-[butane-1,4-diylbis(oxy)]bis(7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium) diiodide
-
-
3,3'-[dodecane-1,12-diylbis(oxy)]bis(5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinoline)
-
-
3,3'-[dodecane-1,12-diylbis(oxy)]bis(7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium) diiodide
-
-
3,3'-[hexane-1,6-diylbis(oxy)]bis(5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinoline)
-
-
3,3'-[hexane-1,6-diylbis(oxy)]bis(7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium) diiodide
-
-
3,3'-[octane-1,8-diylbis(oxy)]bis(5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinoline)
-
-
3,3'-[octane-1,8-diylbis(oxy)]bis(7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine)
-
-
3,3'-[octane-1,8-diylbis(oxy)]bis(7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium) diiodide
-
-
3,3'-[pentane-1,5-diylbis(oxy)]bis(5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinoline)
-
-
3,3'-[pentane-1,5-diylbis(oxy)]bis(7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium) diiodide
-
-
3,3'-[propane-1,3-diylbis(oxy)]bis(5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinoline)
-
-
3,3'-[propane-1,3-diylbis(oxy)]bis(7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium) diiodide
-
-
3-(3-methylphenyl)-2H-chromen-2-one
-
-
3-(4-methylphenyl)-2H-chromen-2-one
-
-
3-(4-propoxybenzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-(6-oxo-6-(8-oxooctahydro-2H-2,6-methanopyrido(1,2-a)(1,5)diazocin-3(4H)-yl)hexanoyl)decahydro-8H-1,5-methanopyrido(1,2-a)(1,5)diazocin-8-one
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
3-(6-oxo-6-(8-oxooctahydro-2H-2,6-methanopyrido(1,2-a)(1,5)diazocin-3(4H)-yl)hexanoyl)decahydro-8H-1,5-methanopyrido(1,2-a)(1,5)diazocin-8-one
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
3-(9-hydroxy-5,6-dimethyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-yl)propane-1,2-diol
-
-
3-(9-methoxy-5,6-dimethyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-yl)propane-1,2-diol
-
-
3-(diethylamino)propyl 10H-phenothiazine-10-carboxylate
-
-
3-(N,N-dimethylamino) phenyl phenothiazine carbamate
-
binding by residues F329 and Y332, structure, overview
3-([7-[methyl(3-[[(methylamino)oxy]carbonyl]benzyl)amino]heptyl]oxy)-9H-xanthen-9-one
-
-
3-carene
-
50% inhibition at 2 mM
3-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
-
3-chlorophenyl 1-methylhydrazinecarboxylate
-
-
3-chlorophenyl phenothiazine carbamate
-
-
3-hydroxy-2,2,6-trimethyl-3,4,5,6-tetrahydro-2H-pyrano[3,2c] quinoline 5-one
-
isolated from Skimmia laureola
3-methoxy-6-methyl-9H-xanthen-9-one
-
-
3-methoxy-7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium iodide
-
micromolar non-selective inhibitor
3-methoxyphenyl phenothiazine carbamate
-
-
3-methyl-2-(4-methylphenyl)-4H-chromen-4-one
-
-
3-methyl-N-(4-(8,9,10,11-tetrahydro-6H-azocino-[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,-10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)butanamide
-
-
-
3-methylphenyl phenothiazine carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-alkyl) carbamates
-
inhibit quickly by carbamoylation
3-N,N-diethylaminophenyl-N'-(1-butyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-ethyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-hexyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-octyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-propyl) carbamate
-
-
3-O-acetylhamayne
-
-
3-[(methyl[7-[(9-oxo-9H-xanthen-3-yl)oxy]heptyl]amino)methyl]phenyl methylcarbamate
-
-
3-[10-(benzylmethylamino)decyloxy]xanthen-9-one
-
-
3-[11-(benzylmethylamino)undecyloxy]xanthen-9-one
-
-
3-[12-(benzylmethylamino)dodecyloxy]xanthen-9-one
-
-
3-[3-(benzylmethylamino)propoxy]xanthen-9-one
-
-
3-[3-[(2-methoxybenzyl)methylamino]propoxy]-xanthen-9-one
-
-
3-[4-(benzylmethylamino)butoxy]xanthen-9-one
-
-
3-[4-[3-(diethylamino)propoxy]benzyl]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one
-
-
3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one
-
-
3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one
-
-
3-[7-(benzylmethylamino)heptyloxy]-6-methoxyxanthen-9-one
-
-
3-[7-[(2,3-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
-
-
3-[7-[(2,5-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
-
-
3-[7-[(2-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[(2-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
-
3-[7-[(3-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[(3-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
-
3-[7-[(4-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[(4-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
-
3-[7-[ethyl-(2-methoxybenzyl)amino]heptyloxy]-xanthen-9-one
-
-
3-[7-[methyl-(2,3,4-trimethoxybenzyl)amino]-heptyloxy]xanthen-9-one
-
-
3-[7-[methyl-(2-methylbenzyl)amino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[methyl-(2-nitrobenzyl)amino]heptyloxy]-xanthen-9-one
-
-
3-[8-(benzylmethylamino)octyloxy]xanthen-9-one
-
-
3-[9-(benzylmethylamino)nonyloxy]xanthen-9-one
-
-
3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones
-
structure-activity relationships, overview, inhibition with high selectivity toward BuChE
3a,8-dibenzyl-1-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
-
-
3a,8-dibenzyl-5-methoxy-1-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
-
-
3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl (2-methylphenyl)carbamate
-
50% inhibition above 0.030 mM
3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 27 nM
3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl ethylcarbamate
-
50% inhibition at 6 nM
4,4'-(3-oxopentane-1,5-diyl)bis(N,N-dimethyl-N-prop-2-en-1-ylanilinium) dibromide
-
i.e. BW284c51, cholinesterase from large fish is more sensitive to inhibition
4,4'-Bipyridine
-
competitive, reversible
4,5-diethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-(aminocarbonyl)-1-(((2-((Z)-(hydroxyimino)methyl)pyridinium-1-yl)methoxy)methyl)pyridinium dichloride
-
i.e. HI-6, reversible, detailed kinetic analysis and comparison with acetylcholinesterase EC 3.1.1.7
4-biphenyl phenothiazine carbamate
-
-
4-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
-
4-chlorophenyl 1-methylhydrazinecarboxylate
-
-
4-chlorophenyl phenothiazine carbamate
-
-
4-cymene
-
isolated from Melaleuca atlernifolia
4-ethenyl-5-ethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-hexyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-methyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-pentyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-propyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-5-hexyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine hydrobromide
-
-
4-ethyl-5-methyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-5-pentyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-5-propyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-N-methyl-dihydrophenanthridine
-
-
4-isopropyl benzaldehyde
-
30.4% inhibition at 1 mM
4-methoxyphenyl phenothiazine carbamate
-
-
4-methyl-N-(4-(8,9,10,11-tetrahydro-6H-azocino-[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,-10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)pentanamide
-
-
-
4-methylphenyl phenothiazine carbamate
-
-
4-Methylumbelliferone
-
80.9% inhibition at 1 mM
4-t-butylphenyl phenothiazine carbamate
-
-
4-[4-[(diethylamino)methyl]phenoxy]-N,N-diethylbutan-1-amine
-
-
4-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropylbutan-1-amine
-
-
5'-O-Methyladenosine
-
-
5,6-dimethoxy-9-prop-2-en-1-yl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-ol
-
-
5,7,8,13-tetrahydroindolo [2',3':3,4]pyrido[2,1-b]quinazoline
-
-
5,8-dihydro-6H isoquino[1,2b]quinazoline
-
-
5-(1,2-dithiolan-3-yl)-N-[8-(6,7,8,9,10,11-hexahydro-13H-azocino[2,1-b]quinazolin-13-ylideneamino)-octyl]pentanamide
-
-
5-(2-diethyaminoethyl)diethyl thiophosphonate
-
-
-
5-butyl-4-ethenyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
5-butyl-4-ethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
5-deoxy-5-azido-1,4 3,6-dianhydro-D-glucitol
-
5% inhibition at 0.1 mM
5-ethoxy-3,4-dihydro-2H-pyrrole
-
-
5-hydroxy-5,6-seco-dihydrolycorine
-
-
5-hydroxy-5,6-secolycorine
-
-
5-methoxy-1-methyl-3a,8-bis(3-methylbut-2-en-1-yl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
-
-
5-[4-[(diethylamino)methyl]phenoxy]-N,N-diethylpentan-1-amine
-
-
5-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropylpentan-1-amine
-
-
5alpha,8alpha-epidioxy-(24S)-ethylcholesta-6,9(11),22(E)-triene-3beta-ol
-
isolated from Haloxylon recurvum
6,7-dimethoxy-2-(3-methylphenyl)-4H-chromen-4-one
-
-
6,7-dimethoxy-3-(3-methylphenyl)-2H-chromen-2-one
-
-
6,7-dimethoxy-3-(4-methylphenyl)-2H-chromen-2-one
-
-
6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
6-hydroxycrinamine
-
-
6-methoxy-2-(3-methylphenyl)-4H-chromen-4-one
-
-
6-methoxy-2-(4-methylphenyl)-4H-chromen-4-one
-
-
6-methoxy-3-(3-methylphenyl)-2H-chromen-2-one
-
-
6-methoxy-3-(4-methylphenyl)-2H-chromen-2-one
-
-
6-O-demethylgalanthamine
-
-
6-[4-[(diethylamino)methyl]phenoxy]-N,N-diethylhexan-1-amine
-
-
6-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropylhexan-1-amine
-
-
6-[7-(benzylmethylamino)heptyloxy]-2,3-dimethoxyxanthen-9-one
-
-
7(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
-
7-bromo-6-methyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-one
-
-
7-exo-(benzylaminocarbonyloxy)-3-oxo-2,5,9-trioxabicyclo [4.3.0] nonane
-
10% inhibition at 0.1 mM
7-methoxy-2-(3-methylphenyl)-4H-chromen-4-one
-
-
7-methoxy-2-(4-methylphenyl)-4H-chromen-4-one
-
-
7-methoxy-3-(3-methylphenyl)-2H-chromen-2-one
-
-
7-methoxy-3-(4-methylphenyl)-2H-chromen-2-one
-
-
7-methoxy-N-nonyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride (1:1)
-
-
7-methoxy-N-octyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
-
7-methoxy-N-pentyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
-
7-methoxy-N-propyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
-
7-methyloctahydro-2H-quinolizin-1-yl (7-methyloctahydro-2H-quinolizin-1-yl)methyl butanedioate
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
7-methyloctahydro-2H-quinolizin-1-yl (7-methyloctahydro-2H-quinolizin-1-yl)methyl butanedioate
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
7-oxo-ent-pimara-8(14),15-diene-19-oic acid
-
-
7-[(diethoxyphosphoryl)oxy]-1-methylquinolinium iodide
-
an irreversible inhibitor
8-alpha-ethoxyprecriwelline
-
-
8-benzyl-1-methyl-3a-(3-methylbut-2-enyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
-
-
8-benzyl-5-methoxy-1-methyl-3a-(3-methylbut-2-enyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
-
-
8-methoxypsoralen
-
67.1% inhibition at 1 mM
8-[4-[(diethylamino)methyl]phenoxy]-N,N-diethyloctan-1-amine
-
-
8-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropyloctan-1-amine
-
-
9,10-dimethoxy-1,2,3,12,15,16-hexadehydrogalanthan
-
-
9-(2-oxo-3-pyrrolidin-1-ylpropyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-(2-oxo-4-pyrrolidin-1-ylbutyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-(2-oxo-5-pyrrolidin-1-ylpentyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-(4-[[2-(dimethylamino)ethyl]amino]-2-oxobutyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-amino-7-methoxy-1,2,3,4-tetrahydroacridine
-
-
-
9-O-[(2-(3-methyl)pyridinium bromide)ethyl]-berberine bromide
-
-
-
9-O-[(2-pyridinium)bromide ethyl]-berberine bromide
-
-
-
9-O-[(3-o xo-3-p-chlorophenylamino)propyl]-berberine bromide
-
-
-
9-O-[(3-oxo-3-p-methoxyamino)propyl]-berberine bromide
-
-
-
9-O-[(3-oxo-3-p-nitrophenylamino)propyl]-berberine bromide
-
-
-
9-O-[(3-oxo-3-p-tolylamino)propyl]-berberine bromide
-
-
-
9-O-[(3-oxo-3-phenylamino)propyl]-berberine bromide
-
-
-
9-O-[(3-pyridinium bromide)propyl]-berberine dibromide
-
-
-
9-O-[3-(2-pyridinoxyl)butyl]-berberine bromide
-
-
-
9-O-[3-(3-methyl pyridinium bromide)propyl]-berberine bromide
-
-
-
9-O-[3-(4-bromo-phenoxyl)butyl]-berberine bromide
-
-
-
9-O-[3-(4-bromo-phenoxyl)propyl]-berberine bromide
-
-
-
9-O-[3-(4-chloro-phenoxyl) butyl]-berberine bromide
-
-
-
9-O-[3-(4-chloro-phenoxyl)propyl]-berberine bromide
-
-
-
9-O-[3-(4-methoxy-phenoxyl)-propyl]-berberine bromide
-
-
-
9-O-[3-(4-methoxy-phenoxyl)butyl]-berberine bromide
-
-
-
9-O-[3-(4-methyl-phenoxyl) propyl]-berberine bromide
-
-
-
9-O-[3-(4-nitro-phenoxyl)butyl]-berberine bromide
-
-
-
9-O-[3-(4-nitro-phenoxyl)propyl]-berberine bromide
-
-
-
9-O-[3-(N-methyl-phenylamino)propyl]-berberinebromide
-
-
-
9-O-[3-(naphthalen-2-yloxy)butyl]-berberine bromide
-
-
-
9-O-[3-(naphthalen-2-yloxy)propyl]-berberine bromide
-
-
-
9-O-[3-(naphthalene-2-ylthio)butyl]-berberine bromide
-
most potent BuChE inhibito
-
9-O-[3-(naphthalene-2-ylthio)propyl]-berberine bromide
-
-
-
9-O-[3-(phenylamino)propyl]-berberine bromide
-
-
-
9-[3-(dimethylamino)-2-oxopropyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[4-(diethylamino)-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[4-(dimethylamino)-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[4-[(2-hydroxyethyl)amino]-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[5-(dimethylamino)-2-oxopentyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
Acetylthiocholine
-
substrate inhibition
Aldicarb
-
cholinesterase from small fish is more sensitive to inhibition
Aldicarb
-
cholinesterase from male fish is more sensitive to pesticide inhibition
alpha-pinene
-
23.5% inhibition at 1 mM
alpha-terpinen
-
isolated from Melaleuca atlernifolia
ambenonium
-
1 mM, 18% inhibition, 10 mM 50% inhibition
amlodipine
-
-
amlodipine besylate
-
reversible mixed-type inhibition
amlodipine besylate
-
-
ammonium(5-hydroxycarvacryl) trimethyl chloride piperidine carboxylate
-
i.e. AMO-1618, growth retardant, 1 mM, 85% inhibition
ammonium(5-hydroxycarvacryl) trimethyl chloride piperidine carboxylate
-
10 mM, 74% inhibition
Androst-1,4-dien-3,17-dione
-
-
androst-4-en-3,7-dione
-
-
Anethum graveolens essential oil
-
90.9% inhibition
-
anthracene
-
reversible
atricarpan A
-
-
atricarpan B
-
-
atricarpan C
-
-
atricarpan D
-
-
atropine
-
competitive
axillaridine A
-
-
axillarine C
-
-
axillarine F
-
-
azamethiphos
-
-
azinphos-methyl
-
formation of the oxon derivative by the enzyme
baicalein
-
an alkaloid isolated from Isatis tinctoria
bambuterol
-
inhibition in the nanomolar range
bambuterol
-
a specific and stereoselective inhibitor of butyrylcholinesterase, which is about 8000times faster inhibited than acetylcholinesterase. Leucine 295 and alanine 337 are crucial residues in BChE for high bambuterol selectivity, preferred inhibition by the R- over the S-bambuterol
Benzene
-
reversible
Benzoylcholine
-
competitive
benzoylthiocholine
-
substrate inhibition
Berberine
-
-
-
beta-pinene
-
31.3% inhibition at 1 mM
Biphenyl
-
reversible
-
biphenyl-2-yl butylcarbamate
-
-
bis-Hup A
-
-
-
bis-Hup B
-
-
-
bisnorcymserine
-
inhibition in the nanomolar range
bisnorcymserine
-
-
bulbocapnine
-
isolated from Corydalis cava
butyl carbamate
-
-
Butyrylcholine
-
competitive to butyrylthiocholine
butyrylthiocholine
-
competitive
butyrylthiocholine
-
substrate inhibition above 10 mM
butyrylthiocholine
-
competitive to butyrylcholine
butyrylthiocholine
-
substrate inhibition
buxabenzacinine
-
isolated from Buxus hyrcana
buxandrine
-
isolated from Buxus hyrcana
buxidin
-
isolated from Buxus hyrcana
buxippine-K
-
isolated from Buxus hyrcana
buxoviricine
-
isolated from Buxus hyrcana
BW284c51
-
inhibits acetylthiocholinesterase and propionylthiocholinesterase activities, but not butyrylthiocholineesterase activity
BW284c51
-
inhibits acetylthiocholinesterase, propionylthiocholinesterase and butyrylthiocholineesterase activities
BW284c51
-
i.e. bis(4-allyl dimethyl ammoniumphenyl) pentane-3-one dibromide
BW284c51
-
i.e. 1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide, seletive inhibition of acetylthiocholine esterase activity
BW284c51
-
i.e. 1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide, seletive inhibition of acetylthiocholine esterase activity
BW284c51
-
specific inhibition of acetylthiocholinesterase activity
BW284c51
-
irreversible inhibitor
BW284c51
-
67.4-88.4% inhibition at 0.001 mM
Carbaryl
-
selectively inhibits isozyme E1
carinatumin A
-
-
carvacrol
-
isolated from Thymus vulgaris essential oil
carvacrol
-
54.6%inhibition at 1 mM
cherylline
-
-
Chlordiazepoxide
-
-
chlordiazepoxide HCl
-
reversible mixed-type inhibition
chlordiazepoxide HCl
-
-
chlorobenzene
-
reversible
chlorogenic acid
-
30.8% inhibition at 1 mM
Chlorpromazine
-
not inhibitory to EC 3.1.1.7
chlorpyrifos
-
the enzyme activity is significantly decreased by environmental realistic chlorpyrifos concentrations of 2.86 and 14.2 nM after seven days of contact
chlorpyrifos
-
inhibits the enzyme and is toxic and lethal to the earthworm when exposed to the organohosphorus insecticide
chlorpyrifos
-
-
chlorpyrifos oxon
-
Michaelis-Menten kinetics, ki: 3048 nM/h, KD: 2.02 nM
chlorpyrifos-oxon
-
-
chlorpyriphos-oxon
-
irreversible inhibitor
choline
-
competitive
citral
-
32.6% inhibition at 1 mM
citronellal
-
60.6% inhibition at 1 mM
citronellol
-
55.4% inhibition at 1 mM
clomipramine
-
competitive inhibition
corydine
-
specific for BChE
crinamidine
-
-
cryptotanshinone
-
uncompetitive inhibitor
cuminyl alcohol
-
18.1% inhibition at 1 mM
Cycloartenol
-
-
cyclopentyl phenothiazine carbamate
-
-
cyclosarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
cymserine
-
inhibition in the nanomolar range
cymserine
-
50% inhibition at 53 - 100 nM at substrate concentrations 0.025 - 0.8 mM, detailed kinetic analysis
cymserine
-
BChE selective inhibitor
D-borneol
-
12.1% inhibition at 1 mM
dec-N-dimethylregeline
-
-
dehydroevodiamine hydrochloride
-
isolated from Evodia rutaecarpa
demethyldebromoflustramine B
-
-
diazepam
-
reversible mixed-type inhibition
diazinon
-
an insecticide toxic to the fish via inhibition of brain cholinesterase
diazoxon
-
second order rate constant for inhibition is 77000000 per M and min
Dibucaine
-
-
Dichlorvos
-
enzyme activity can be restored by incubation with pyridine-2-aldoxime methochloride
Dichlorvos
-
organophosphate insecticide
Diethyl p-nitrophenyl phosphate
-
0.001 mM, 71% inhibition; i.e. paraoxon
Diethyl p-nitrophenyl phosphate
-
i.e. paraoxon
diethylphosphochloridate
-
-
diethylphosphofluoridate
-
-
dihydrobenzodioxepine cymserine
-
i.e. DHBDC
dihydrocarvone
-
66.5% inhibition at 1 mM
dihydrotanshinone
-
uncompetitive inhibitor
-
diisopropyl fluorophosphate
-
comparison with inhibitory potency in brain tissue of different Salmonidae
diisopropyl fluorophosphate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
diisopropyl phosphorofluoridate
-
rank order of decreasing inhibition: soman, sarin, diisopropyl phosphorofluoridate, echothiohate, paraoxon
diisopropylfluorophosphate
-
DFP, selective inhibitor
diisopropylfluorophosphate
-
-
diisopropylphosphofluoridate
-
irreversible inhibition
diisopropylphosphofluoridate
-
diisopropyl fluorophosphate
diisopropylphosphofluoridate
-
-
diisopropylphosphofluoridate
-
DFP, irreversible, covalent inhibition
donepezil
-
50% inhibition at 0.004 mM
donepezil
-
50% inhibition at 4150 nM
donepezil
-
standard drug against Alzheimer's disease, mixed type inhibition, Ki: 1.41 mg/ml
Echothiophate
-
enzyme spontaneously reactivates with a half-life of 4.3 h
Echothiophate
-
an organophosphorous compound, inhibition kinetics, overview
EDTA
-
inhibitory above 1 mM
ent-kaur-16-en-19-oic-acid
-
-
ent-pimar-15-en-8 alpha, 19-diol
-
-
ent-pimara-8(14),15-diene-19-oic acid
-
-
ent-pimara-8(14),15-diene-19-ol
-
-
epibuphasine
-
-
epiglucoisatisin
-
an alkaloid isolated from Isatis tinctoria
epivittatine
-
-
eptastigmine
-
inhibition in the nanomolar range
eptastigmine
-
50% inhibition at 5 nM
eserine
-
native enzyme, 50% inhibition at 5 nM, recombinant enzyme, 50% inhibition at 5 nM
eserine
-
i.e. physostigmine, as hemisulfate salt, 82% inhibition at 1 mM, 72% at 0.05 mM
eserine
-
i.e. physostigmine, as hemisulfate salt, 94% inhibition at 0.001 mM, 88% at 0.01 mM
eserine
-
cholinesterase from female fish is more sensitive to pesticide inhibition
eserine
-
non-selective cholinesterase inhibitor, more than 90% inhibition at 0.1 mM
ethanolic extract from Pimpinella anisodes
-
IC50: 362.1 microgram/ml
-
ethopropazine
-
inhibits at low substrate concentrations, inhibition mechanism
ethopropazine
-
inhibition in the nanomolar range
ethopropazine
-
not inhibitory to EC 3.1.1.7
ethopropazine
-
-
ethopropazine
-
specific inhibitor
ethopropazine
-
selective inhibition
ethopropazine hydrochloride
-
1 mM, 28% inhibition
ethopropazine hydrochloride
-
-
ethopropazine hydrochloride
-
0.1 mM, complete inhibition
ethyl carbamate
-
-
ethyl carbamoyl
-
native enzyme, 50% inhibition at 10 nM, recombinant enzyme, 50% inhibition at 5 nM
ethyl propazine methosulfate
-
0.1 mM, complete inhibition; i.e. Lysivane
-
ethyl [2-[(5aS,7R,9aS)-1-formyl-7-hydroxy-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl]methylcarbamate
-
-
ethyl [2-[(5aS,7R,9aS)-7-hydroxy-1-(hydroxymethyl)-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl]methylcarbamate
-
-
ethylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
Eugenol
-
45.4% inhibition at 1 mM
Farnesol
-
33.0% inhibition at 1 mM
fenobucarb
-
an insecticide toxic to the fish via inhibition of brain cholinesterase
fluoride
-
reversible inhibitor, forms a complex with the enzyme
Foeniculum vulgare essential oil
-
flowering, 65.4% inhibition; fully-mature, 71.6% inhibition
-
FP-biotin
-
i.e. 10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide, second order rate constant for inhibition is 160000000 per M and min, binding affinity is about 5.8 nM
galantamin
-
-
galantamine
-
50% inhibition at 0.0073 mM
galantamine
-
slight reversible inhibition
galanthamine
-
50% inhibition at 7300 nM
galanthamine
-
-
galanthamine
-
-
galanthamine
-
an alkaloid isolated from Isatis tinctoria
galanthamine
-
-
galanthamine
-
80.3% inhibition at 1 mM
galanthamine
-
80.3% inhibition at 1 mM
Gallic acid
-
48.8% inhibition at 1 mM
gamma-terpinen
-
isolated from Melaleuca atlernifolia
genistein
-
65.7% inhibition at 1 mM
geraniol
-
21.1% inhibition at 1 mM
geranyl ester
-
59.1% inhibition at 1 mM
haloxyline A
-
-
haloxyline B
-
-
HgCl2
-
following Palaemon serratus exposure to HgCl2, no effect on ChE activity is observed. By contrast, following 24 h exposure to dichlorvos, decrease of ChE activity is observed until 30 to 40% basal activity
HI 6
-
competitive, reversible
homatropine
-
competitive
homoproaporphine
-
-
-
huperzine
-
50% inhibition at 0.03 mM
huperzine A
-
50% inhibition above 10000 nM
huperzine A
-
-
huperzine A
-
-
huperzine B
-
-
huperzine R
-
-
hydralazine
-
-
hydralazine HCl
-
reversible mixed-type inhibition
hydralazine HCl
-
-
hyrcamine
-
isolated from Buxus hyrcana
hyrcanone
-
isolated from Buxus hyrcana
hyrcatrienine
-
isolated from Buxus hyrcana
imipramine
-
competitive inhibition
Indene
-
reversible
iodine methylated 2-dimethylaminoethyl esters of N-substituted alpha,beta-dehydrophenylalanine
-
inhibition potencies, overview
-
iodoacetic acid
-
-
iolantamine iodomethylate
-
-
iprobenfos
-
i.e. IBP or kitazin
isatan A
-
an alkaloid isolated from Isatis tinctoria
isatan B
-
an alkaloid isolated from Isatis tinctoria
iso-butylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
iso-menthone
-
64.7% inhibition at 1 mM
iso-ompa
-
inhibition in the nanomolar range
iso-ompa
-
inhibits butyrylthiocholineesterase activity
iso-ompa
-
i.e. tetaisopropyl diphosphoramide
iso-ompa
-
i.e. tetra-(monoisopropyl)diphosphor-tetramide, selective inhibition of butyrylthiocholine esterase activity
iso-ompa
-
i.e. tetra-(monoisopropyl)diphosphor-tetramide, selective inhibition of butyrylthiocholine esterase activity
iso-ompa
-
i.e. tetra-isopropyl-diphosphatamide
iso-ompa
-
i.e. tetraisopropyl diphosphoramide, inhibits the butyrylthiocholine esterase activity
iso-ompa
-
specific for BuChE
iso-ompa
-
specific inhibitor of BuChE
iso-propyl carbamate
-
-
iso-pulegol
-
44.7% inhibition at 1 mM
isolariin A
-
isolated from Linaria reflexa
isolariin B
-
isolated from Linaria reflexa
isoquinolin-1-yl(2-methoxyphenyl)methanol
-
-
isosorbide-di-(4-nitrophenyl carbamate)
-
-
isosorbide-di-(benzylcarbamate)
-
77% inhibition at 0.1 mM
isosorbide-di-(butylcarbamate)
-
13% inhibition at 0.1 mM
isosorbide-di-(ethylcarbamate)
-
-
isosorbide-di-(propylcarbamate)
-
28% inhibition at 0.1 mM
isosorbide-di-phenylcarbamate
-
77% inhibition at 0.1 mM
Jatrorrhizine
-
-
K074
-
a bispyridinium para-aldoxime with butane linker, reversible inhibition
K075
-
a bispyridinium para-aldoxime with but-2-ene linker, reversible inhibition
K114
-
a bispyridinium para-aldoxime with xylene-like linker, reversible, noncompetitive inhibition
kaempferol
-
-
kesselridine
-
-
kesselridine iodomethylate
-
-
kesselringine
-
-
Lavandula officinalis essential oil
-
chemical fertilizer, 95.0% inhibition; organic fertilizer, 92.9% inhibition
-
lawsaritol
-
isolated from Haloxylon recurvum
leufolin A
-
isolated from Leucas urticifolia
leufolin B
-
isolated from Leucas urticifolia
linalool
-
isolated from Thymus vulgaris essential oil
linalool
-
15.7% inhibition at 1 mM
linalyl ester
-
35.8% inhibition at 1 mM
linalyl oxide
-
29.0% inhibition at 1 mM
lovastatin
-
reversible mixed-type inhibition
lovastatin
-
-
luteidine iodomethylate
-
-
luteolin 7-O-rutinoside
-
54.9% inhibition at 1 mM
lycoposerramine
-
-
malachite green
-
linear mixed inhibition
malachite green
-
-
malathion
-
-
maloxan
-
-
-
maritidine
-
-
meldola blue
-
-
Melissa officinalis essential oil
-
chemical fertilizer, 66.5% inhibition; organic fertilizer, 73.3% inhibition
-
Mentha piperita essential oil
-
organic fertilizer, 93.5% inhibition
-
Mentha spicata essential oil
-
organic fertilizer, 91.0% inhibition
-
menthofurane
-
55.4% inhibition at 1 mM
menthol
-
70.0% inhibition at 1 mM
merenderin
-
-
methanolic exrtact of Dictyota dichotoma
-
methanolic extract, noncompetitive type inhibition, , Ki: 0.9 mg/ml
-
methanolic exrtact of Enteromorpha intestinalis
-
methanolic extract, mixed-type inhibition, Ki: 0.95 mg/ml
-
methanolic exrtact of Hypnea valentine
-
methanolic extract, mixed-type inhibition, Ki: 0.75 mg/ml
-
methanolic exrtact of Ulva reticulate
-
methanolic extract, mixed-type inhibition, Ki: 0.6 mg/ml
-
methyl carbamate
-
-
methyl green
-
competitive
methyl green
-
-
methyl isoplatydesmine
-
specific for BChE
methylene blue
-
-
methylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
metoclopramide
-
0.001-0.0019 mM, 50% competitive inhibition
morphine
-
0.0013 mM, 6% inhibition
myricetin
-
-
N,N'-bis(3-pyridin-3-ylcyclohexyl)pentanediamide
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
N,N'-bis(3-pyridin-3-ylcyclohexyl)pentanediamide
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
N,N'-diisopropylphosphorodiamidic fluoride
-
Mipafox, irreversible, covalente inhibition
N,N,N',N'-tetramethyl-1,6-hexane diamine
-
-
N,N,N,N',N',N'-hexamethylbutane-1,4-diaminium
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
N,N,N,N',N',N'-hexamethylbutane-1,4-diaminium
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
N,N,N-trimethyl-2-([(2Z)-3-phenyl-2-[(phenylcarbonyl)amino]prop-2-enoyl]oxy)ethanaminium iodide
-
-
N,N,N-trimethyl-2-oxo-3-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)propan-1-aminium
-
-
N,N,N-trimethyl-3-oxo-4-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)butan-1-aminium
-
-
N,N,N-trimethyl-4-oxo-5-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)pentan-1-aminium
-
-
N,N,N-trimethylmethanaminium
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
N,N,N-trimethylmethanaminium
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
N,N-bis(3-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)propyl) acetamide
-
-
-
N,N-bis(3-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)acetamide
-
-
-
N,N-dibutyl-10-[4-[(diethylamino)methyl]phenoxy]decan-1-amine
-
-
N,N-dibutyl-4-[4-[(diethylamino)methyl]phenoxy]butan-1-amine
-
-
N,N-dibutyl-5-[4-[(diethylamino)methyl]phenoxy]pentan-1-amine
-
-
N,N-dibutyl-6-[4-[(diethylamino)methyl]phenoxy]hexan-1-amine
-
-
N,N-dibutyl-8-[4-[(diethylamino)methyl]phenoxy]octan-1-amine
-
-
N-(2-phenylethyl)-N-[(12Z)-7,8,9,10-tetrahydroazepino [2,1b]quinazolin-12(6H)-ylidene]amine
-
-
N-(3-([6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]amino)propyl)-5-(1,2-dithiolan-3-yl)pentanamide
-
-
N-(4-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylid -eneamino)butyl)-N-(3-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)propyl)acetamide
-
-
-
N-(4-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)butyl)-N-(3-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)propyl) methacrylamide
-
-
-
N-(4-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)butyl)-N-(3-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)propyl) propionamide
-
-
-
N-(4-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,11-tetrahydro--6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)-acetamide
-
-
-
N-(4-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)-methacrylamide
-
-
-
N-(4-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)-pentanamide
-
-
-
N-(4-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)-pivalamide
-
-
-
N-(4-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)-propionamide
-
-
-
N-(6,7,8,9,10,11-hexahydro-13H-azocino[2,1-b]quinazolin-13-ylidene)octane-1,8-diamine
-
-
N-(8-([6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]amino)octyl)-5-(1,2-dithiolan-3-yl)-pentanamide
-
-
N-butyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
-
n-butylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
N-desmethyl-8alpha-ethoxypretazzettine
-
-
N-desmethyl-8beta-ethoxypretazzettine
-
-
N-ethyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
-
N-ethyl-N-(4-[[10-(4-ethylpiperazin-1-yl)decyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[10-(4-methylpiperazin-1-yl)decyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[10-(piperidin-1-yl)decyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[10-(pyrrolidin-1-yl)decyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[5-(4-ethylpiperazin-1-yl)pentyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[5-(4-methylpiperazin-1-yl)pentyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[5-(piperidin-1-yl)pentyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[5-(pyrrolidin-1-yl)pentyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[6-(4-ethylpiperazin-1-yl)hexyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[6-(4-methylpiperazin-1-yl)hexyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[6-(piperidin-1-yl)hexyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[6-(pyrrolidin-1-yl)hexyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[8-(4-ethylpiperazin-1-yl)octyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[8-(4-methylpiperazin-1-yl)octyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[8-(piperidin-1-yl)octyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[8-(pyrrolidin-1-yl)octyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-[4-[2-(4-methylpiperazin-1-yl)ethoxy]benzyl]ethanamine
-
-
N-ethyl-N-[4-[2-(piperidin-1-yl)ethoxy]benzyl]ethanamine
-
-
N-ethyl-N-[4-[4-(4-methylpiperazin-1-yl)butoxy]benzyl]ethanamine
-
-
N-ethyl-N-[4-[4-(piperidin-1-yl)butoxy]benzyl]ethanamine
-
-
N-ethyl-N-[4-[4-(pyrrolidin-1-yl)butoxy]benzyl]ethanamine
-
-
N-hexyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine
-
-
N-hexyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
-
N-methyl, N-alkyl carbamates
-
inhibition of human BChE by divers derivatives of phenylethylamines and aminoindans is less influenced by the size of the alkyl group and more dependent on the structure of the leaving group, overview
-
N-methyl-3-pyridin-3-ylcyclohexanamine
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
N-methyl-3-pyridin-3-ylcyclohexanamine
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
N-methyl-7-exo-(benzylaminocarbonyloxy-)-3-oxo-5,9-dioxa-2-azabicyclo[4.3.0] nonane
-
6.5% inhibition at 0.1 mM
N-methyl-N-(3-carbamoyloxyphenyl)methyl-amino inhibitor
-
-
N-methylphenothiazine
-
not inhibitory to EC 3.1.1.7
n-propylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
N-[6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]-1-butanamine
-
-
N-[6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]hexane-1,6-diamine
-
-
N-[6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]octane-1,8-diamine
-
-
N1-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene)-N3-(3-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)propyl)-N3-methylpropane-1,3-diamine
-
-
-
N1-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene)-N4-(3-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)propyl)-N4-methylbutane-1,4-diamine
-
-
-
N1-methyl-N3-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylidene)-N1-(3-(8,9,10,11-tetrahydro-6Hazocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)propane-1,3-diamine
-
-
-
N3-demethylsaracodine
-
-
Naphthalene
-
reversible
naringin
-
13.7% inhibition at 1 mM
Nb-dimethylcycloxobuxoviricine
-
isolated from Buxus hyrcana
Neostigmine
-
-
Neostigmine
-
0.0006 mM, 50% inhibition
Neostigmine
-
0.008 mM neostigmine bromide, complete inhibition
neostigmine bromide
-
-
nerol
-
30.8% inhibition at 1 mM
nifedipine
-
reversible mixed-type inhibition
nifedipine
-
-
O,O-diethyl-4-nitrophenylphosphate
-
syn: paraoxon, rank order of decreasing inhibition: soman, sarin, diisopropyl phosphorofluoridate, echothiohate, paraoxon
O,O-diethyl-S-(2-N,N,N-trimethylammonioethyl) phosphorothiolate iodide
-
syn: echothiophate, rank order of decreasing inhibition: soman, sarin, diisopropyl phosphorofluoridate, echothiohate, paraoxon
O-acetyllycorine
-
-
O-ethyl-S-3,3-dimethylbutyl methylthiophosphonate
-
comparison with inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-3,3-dimethylbutyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-ethyl methylthiophosphonate
-
-
O-ethyl-S-n-heptyl methylthiophosphonate
-
comparison with inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-heptyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-hexyl methylthiophosphonate
-
comparison with inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-hexyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-pentyl methylthiophosphonate
-
comparison with inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-pentyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-pentyl methylthiophosphonate
-
LG-64
O-hexyl-S-ethyl methylthiophosphonate
-
-
O-isopropyl methylphosphonofluoridate
-
syn: sarin, rank order of decreasing inhibition: soman, sarin, diisopropyl phosphorofluoridate, echothiohate, paraoxon
O-isopropyl S-(diisopropylaminoethyl)methyl thiophosphonate
-
-
-
O-methylmaritidine
-
-
O-pinacolyl methylphosphonofluoridate
-
syn: soman, rank order of decreasing inhibition: soman, sarin, diisopropyl phosphorofluoridate, echothiohate, paraoxon
Ocimum basilicum essential oil
-
green variety, 74.1% inhibition; purple variety, 79.1% inhibition
-
octahydro-2H-quinolizin-1-yl octahydro-2H-quinolizin-1-ylmethyl butanedioate
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
octahydro-2H-quinolizin-1-yl octahydro-2H-quinolizin-1-ylmethyl butanedioate
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
octahydro-2H-quinolizin-1-ylmethanol
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
octahydro-2H-quinolizin-1-ylmethanol
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
organophosphorus compounds
-
determination of reactivation efficiency with oxims, e.g. obixime, 2-PAM, HI 6, HL 7, and MMB-4, reactivation kinetics, overview, structure-activity relationship for inhibition and spontaneous reactivation, overview
-
Origanum majorana essential oil
-
organic fertilizer, 94.4% inhibition
-
Origanum munitiflorum essential oil
-
organic fertilizer, 94.7% inhibition
-
Origanum onites essential oil
-
organic fertilizer, 92.9% inhibition
-
Origanum vulgare essential oil
-
organic fertilizer, 88.4% inhibition
-
oxazaphenalene lactone
-
-
p-chloromercuribenzoate
-
-
p-hydroxybenzoic acid
-
-
PAM-2
-
competitive, reversible
-
papyramine
-
-
Paraoxon
-
enzyme activity can be restored by incubation with pyridine-2-aldoxime methochloride
Paraoxon
-
50% inhibition at 0.0028 mM
Paraoxon
-
activity of cholinesterase reactivators pralidoxime, obidoxime, trimedoxime, methoxime and H-oxime HI-6, i.e. 1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2-oxapropane dichloride, in reactivation of plasma BuChE inhibited by pesticide paraoxon, efficacies, none of tested oximes surpassed 12.5% of BuChE reactivation, overview
Paraoxon
-
cholinesterase from small fish is more sensitive to inhibition
Paraoxon
-
cholinesterase from male fish is more sensitive to pesticide inhibition
Paraoxon
-
paraoxon binds to both the enzyme and acyl-enzyme, but with weak affinities. A slight activation is observed at the lowest paraoxon concentrations and is attributed to the binding of the substrate to the enzyme-inhibitor complex
Paraoxon
-
i.e. diethyl-4-nitrophenylphosphate, irreversible inhibition
pararosaniline
-
linear mixed inhibition
pararosaniline
-
-
parathion
-
50% inhibition at 0.022 mM
parathion
-
-
paroxetine
-
mixed-type inhibition
phenethyl cymserine
-
native enzyme, 50% inhibition at 7 nM, recombinant enzyme, 50% inhibition at 50 nM
phenothiazine
-
not inhibitory to EC 3.1.1.7
phenserine
-
50% inhibition at 0.0015 mM
phenserine
-
native enzyme, 50% inhibition at 500 nM, recombinant enzyme, 50% inhibition at 500 nM
phenserine
-
50% inhibition at 1560 nM
phenyl 1,2-dimethylhydrazinecarboxylate
-
-
phenyl 1-methylhydrazinecarboxylate
-
-
phenyl butylcarbamate
-
-
phenyl phenothiazine carbamate
-
-
phenylcoumarin
-
-
phenylethylcymserine
-
inhibition in the nanomolar range
phosphostigmine
-
competitive, reversible
physostigmine
-
inhibition in the nanomolar range
physostigmine
-
-
physostigmine
-
-
physostigmine
-
identified compound of Pimpinella anisodes, IC50: 0.17 microgram/ml
physostigmine
-
-
physostigmine
-
i.e. eserine
physostigmine
-
0.42 mM, 50% inhibition; i.e. eserine
physostigmine
-
0.7 mM physostigmine sulfate, 90% inhibition; i.e. eserine
physostigmine
-
i.e. eserine; irreversible inhibition
physostigmine
-
i.e. eserine
physostigmine
-
i.e. eserine
piperitone
-
76.1% inhibition at 1 mM
pralidoxime
-
significally decreases organophosphate induced mortality of a LD75 dose of paraoxon
procaine
-
competitive
Propionylthiocholine
-
substrate inhibition above 10 mM
propyl phenothiazine carbamate
-
-
proserine
-
comparison with inhibitory potency in brain tissue of different Salmonidae
proserine
-
comparison of inhibitory potency in brain tissue of different Salmonidae
prostigmin
-
-
prostigmin
-
-
protoberberine
-
-
pyridostigmine
-
significally decreases organophosphate induced mortality of a LD75 dose of paraoxon
pyridostigmine
-
-
pyridostigmine bromide
-
native enzyme, 50% inhibition at 300 nM, recombinant enzyme, 50% inhibition at 500 nM
quercetin
-
48.8% inhibition at 1 mM
quercetin
-
-
Quinidine
-
0.007 mM, 5.7% inhibition
Quinidine
-
competitive
regelamine
-
-
regeline iodomethylate
-
-
rivastigmin
-
-
rivastigmine
-
trade name: Exelon, carbamylates the enzyme
rivastigmine
-
50% inhibition at 0.054 mM
rivastigmine
-
50% inhibition at 37 nM
Ro 02-0683
-
progressive inhibitor
-
RP-3,3-dimethylbutyl-methylphosphonyl thiocholine
-
phosphonylates the enzyme, enzyme can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
RP-cycloheptyl-methylphosphonyl thiocholine
-
phosphonylates the enzyme, enzyme can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
RP-isopropyl methylphosphonyl thiocholine
-
phosphonylates the enzyme, enzyme can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
rutaecaerpine
-
-
saligcinnamide
-
-
salignarine-C
-
isolated from Sarcococca saligna
salignenamide A
-
-
salignenamide D
-
-
salignenamide E
-
-
salignenamide F
-
-
Salvia officinalis essential oil
-
organic fertilizer, 66.3% inhibition
-
Salvia sclarea essential oil
-
chemical fertilizer, 45.1% inhibition; organic fertilizer, 76.0% inhibition
-
sarcovagenine-C
-
isolated from Sarcococca saligna
sarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
sarsalignenone
-
-
sarsalignone
-
-
Satureja cuneifolia essential oil
-
organic fertilizer, 98.4% inhibition
-
Scopolamine
-
competitive
scopoletin
-
73.5% inhibition at 1 mM
serine
-
selective ChE inhibitor, 93.1-99.2% inhibition at 0.0005 mM
sertraline
-
mixed-type inhibition
silibinin
-
51.4% inhibition at 1 mM
silymarin
-
43.2% inhibition at 1 mM
simvastatin
-
reversible mixed-type inhibition
simvastatin
-
-
slavin A
-
isolated from Salvia santolinifolia
slavin B
-
isolated from Salvia santolinifolia
Sodium fluoride
-
-
soman
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
SP-3,3-dimethylbutyl-methylphosphonyl thiocholine
-
phosphonylates the enzyme, enzyme can be reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
SP-cycloheptyl-methylphosphonyl thiocholine
-
phosphonylates the enzyme, enzyme can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
SP-isopropyl methylphosphonyl thiocholine
-
phosphonylates the enzyme, enzyme can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
stephaoxocanidine
-
-
Succinylcholine
-
-
sulfoglucobrassicin
-
an alkaloid isolated from Isatis tinctoria
Tabun
-
tabun-inhibited enzymes are reactivated by K074, K075, and K114, kinetics, overview
Tabun
-
the most potent reactivators of tabun-inhibited BChE are 1,1'-(2,2'-oxybis(ethane-2,1-diyl))bis(4-hydroxyiminomethyl pyridinium) bromide and 4-carbamoyl-1-(2-(2-(4-(hydroxyiminomethyl)pyridinium-1-yl)ethoxy)ethyl)pyridinium bromide. Reactivation by these oximes (1 mM) reaches about 50% of control activity after 20 min, however, reactivation stops at 70%
tacrine
-
inhibition in the nanomolar range
tacrine
-
50% inhibition at 47 nM
taspine
-
isolated from Thymus vulgaris essential oil
terpinen-4-ol
-
isolated from Melaleuca atlernifolia
tert-butyl 10H-phenothiazine-10-carboxylate
-
-
testolactone
-
-
testosterone
-
-
tetra monoisopropyl pyrophosphomide
-
50% inhibition at 0.055 mM
tetra(monoisopropyl) diphosphortetramide
-
i.e. iso-OMPA
tetrabutylammonium
-
competitive
tetraethylammonium
-
-
tetraisopropyl diphosphoramide
-
i.e. iso-OMPA
tetraisopropyl diphosphoramide
-
i.e. iso-OMPA
tetraisopropyl diphosphoramide
-
i.e. iso-OMPA, cholinesterase from large fish is more sensitive to inhibition
tetraisopropyl diphosphoramide
-
i.e. iso-OMPA, cholinesterase from male fish is more sensitive to inhibition
tetraisopropyl phosphoramide
-
iso Ompa
tetraisopropyl phosphoramide
-
iso Ompa
tetraisopropyldiphosphoramide
-
iso-OMPA, 98% inhibition at 0.04 mM after 10 min
tetraisopropylpyro-phosphoramide
-
irreversible inhibition
-
Tetramethylammonium
-
-
thioridazine
-
0.0054 mM, 10% inhibition
thymohydroquinone
-
isolated from Thymus vulgaris essential oil
Thymol
-
isolated from Thymus vulgaris essential oil
Thymol
-
27.6% inhibition at 1 mM
thymoquinone
-
isolated from Thymus vulgaris essential oil
tolserine
-
native enzyme, 50% inhibition at 50 nM, recombinant enzyme, 50% inhibition at 80 nM
tolserine N-dimethyl ammonium bromide
-
native enzyme, 50% inhibition at 44 nM, recombinant enzyme, 50% inhibition at 45 nM
Toluene
-
reversible
trans-anethole
-
identified compound of Pimpinella anisodes, IC50: 209.6 microgram/ml
Triton X-100
-
competitive inhibition
Triton X-100
-
inhibition above 0.01 mM
umbelliferone
-
54.3% inhibition at 1 mM
undulatine
-
-
vaganine A
-
-
Vanillin
-
8.5% inhibition at 1 mM
vanilloloside
-
-
VX
-
a nerve agent
xanthostigmine
-
-
xanthostigmine
-
three-dimensional model of the quaternary complex between BuChE and xanthostigmine
Zn2+
-
1-2 mM, 10% activation, inhibitory above
metrifonate
-
50% inhibition at 0.018 mM
additional information
-
enzyme variants usual, fluoride resistant, and atypical differ in rates of inhibition by the charged organophosphates and carbamates
-
additional information
-
no substrate inhibition up to 50 mM butyrylthiocholine iodide
-
additional information
-
not inhibitory: acetaminophen, chlordiazepoxide, chlorpromazine, desipramine, doxepin, imipramine, methamphetamine, nortryptiline, phenobarbital, phenytoin, procainamide, salicylic acid, theophyline, valproic acid
-
additional information
-
ortho electron domating substitutents of the inhibitors accelerate inhibition of enzyme by ortho polar effects
-
additional information
-
comparison of reaction rates with human acetylcholinesterase EC 3.1.1.7 and butyrylcholinesterase EC 3.1.1.8 for several organophosphate inhibitors
-
additional information
-
comparison of 50% inhibitory concentration for various inhibitors of EC 3.1.1.7 and EC 3.1.1.8
-
additional information
-
mo product inhibition with aryl acetylamides
-
additional information
-
no inhibition by chlorpyrifos
-
additional information
-
no inhibition by iso-OMPA
-
additional information
-
specificity of diverse reversible sulfonium inhibitors, overview
-
additional information
-
selectivity of inhibition of different cholinesterase activities in different tissues, in vitro effects of environmental contaminants, overview
-
additional information
-
inhibition of ChE is not lethal
-
additional information
-
some inhibitors fullfill the competitive inhibition model with irreversible reaction between enzyme and inhibitor, but e.g. not galantamin
-
additional information
-
design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties exhibiting competitive and reversible inhibition, overview
-
additional information
-
selectivity and inhibitory potency of isaindigotone derivatives for inhibition of BuChE
-
additional information
-
the engineered recombinant BChE mutant A328W/Y332A displays increased affinity to the organophosphate pesticides paraoxon and malaoxon compared to the wild-type enzyme, overview
-
additional information
-
inhibitor structure-activity relationships, simulation of pseudo-irreversible BuChE covalent inhibitors, overview
-
additional information
-
potency and mechanism of diverse enzyme inhibitors, corydaline and ribalinine, isolated from Skimmia laureola, are specific for acetylcholinesterase, overview
-
additional information
-
design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors, structure-based drug design, overview
-
additional information
-
design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors, overview
-
additional information
-
molecular docking analysis of inhibitors, overview
-
additional information
-
inhibitor molecular mechanics calculations, general mechanism of pseudoirreversible cholinesterase inhibition by carbamates. Enzyme deactivation is initiated by nucleophilic attack of the catalytic triad serine oxygen on the carbonyl group of the carbamate, structure-activity relationships of wild-type and mutant enzymes, overview
-
additional information
-
structure-activity studies of debromoflustramine B analogues as selective BChE inhibitors, molecular modeling, overview
-
additional information
-
modeling, stability, and binding structure of isosorbide-2-carbamate ester inhibitors, overview
-
additional information
-
no inhibition of BChE by caffeic, gallic, and quinic acids, and biochanin A, apigenin, kaempferol-3-O-galactoside, and diosmin
-
additional information
-
76% inhibition by a furanocoumarin mixture obtained from Heracleum crenatifolium, no inhibition by rhapontin, rhein, 4-hydroxycoumarin, aloe-emodine, bergapten and iso-bergapten
-
additional information
-
no inhibition by gamma-terpinene, 4-allyl anisole, cumol, trans-anethole, camphene, iso-borneol, l-bornyl acetate, and 2-heptanol
-
additional information
-
docking study show that flavonoids bind to the BChE active site by forming multiple hydrogen bonds and pi-pi interactions
-
additional information
-
organophosphate and N-methyl-carbamate insecticides inhibit enzyme activity
-
additional information
-
not inhibited by propionylthiocholine and acetyl-beta-metylthiocholine
-
additional information
-
not inhibited by 1 mM tetraisopropyl diphosphoramide
-
additional information
-
not inhibited by 3-methoxy-5,8,9,13b-tetrahydro-6H-isoquino-[1,2-a]isoquinoline and 3-methoxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine
-
additional information
-
not inhibited by tetraisopropyl diphosphoramide
-
additional information
-
enzyme is inhibited by quaternary ammonium salts. The effect is influenced by the size of the quaternary ammonium ion
-
additional information
-
-
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
2,4,6-trinitrotoluene
-
i.e. TNT, a nonessential activator
2,6-dichlorophenolindophenyl acetate
-
exhibits an activatory effect at acid pH values
2,6-dichlorophenolindophenyl acetate
-
activating effect at acidic pH values
2,6-dichlorophenolindophenylacetate
-
activating effect at acidic pH values
2-trimethylsilyl-ethyl-N-n-butylcarbamate
-
substrate activation, essential activator of BChE, kinetics
2-trimethylsilyl-ethyl-N-n-butylcarbamate
-
nonessential activator
3,3-dimethylbutyl-N-n-butylcarbamate
-
substrate activation, essential activator of BChE, kinetics
3,3-dimethylbutyl-N-n-butylcarbamate
-
a nonessential activator
Butyrylcholine
-
substrate activation, overview
citrate
-
20 mM, 140% activity
homocysteine thiolactone
-
non-substrate activation
indophenyl acetate
-
exhibits an activatory effect at acid pH values
indophenyl acetate
-
activating effect at acidic pH values
indophenylacetate
-
activating effect at acidic pH values
additional information
-
activation kinetics and modelling
-
additional information
-
rat plasma BuChE is increased when pretreated with horse BuChE
-
additional information
-
BChE activation kinetics, overview
-
additional information
-
cancer induces the enzyme
-
additional information
-
at pH 5.5, phenylacetate exhibits no activatory effect within a broad concentration range (0.5-100 mM)
-
additional information
-
phenyl acetate does not produce activating effect at pH 5.5 in sufficiently wide substrate concentration ranges (0.5-100 mM)
-
additional information
-
phenylacetate does not produce activating effect at pH 5.5 in sufficiently wide substrate concentration ranges (0.5-100 mM)
-
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
107
-
(+)-cocaine
-
pH 7.4, 25C
0.0031
-
(-)-cocaine
-
pH 7.4, A328W mutant
0.0045
-
(-)-cocaine
-
pH 7.4, wild-type enzyme
0.018
-
(-)-cocaine
-
pH 7.4, A328W/Y332A mutant
0.0245
-
(-)-cocaine
-
pH 7.4, Y332A mutant
0.065
-
(-)-cocaine
-
pH 7.4, 37C
0.023
-
(R)-3-benzoyloxy-1-benzylquinuclidinium bromide
-
24C
0.127
-
(R)-3-benzoyloxy-1-methylquinuclidinium iodide
-
24C
0.065
-
(S)-3-benzoyloxy-1-methylquinuclidinium iodide
-
24C
0.12
-
2-Nitrophenyl butyrate
-
wild-type, pH 7, 25C
0.16
-
2-Nitrophenyl butyrate
-
K339M mutant, pH 7, 25C
1.4
-
2-Nitrophenyl butyrate
-
W82A mutant, pH 7, 25C
1.9
-
2-Nitrophenyl butyrate
-
W430A mutant, pH 7, 25C
0.29
-
acetoacetylcholine
-
-
0.25
-
acetyl-beta-metylthiocholine
-
in 0.1 M phosphate buffer, pH 7.5, at 30C
-
0.027
-
Acetylcholine
-
mutant enzyme A199S/F227A/S287G/A328W/E441D, pH not specified in the publication, at 25C
0.036
-
Acetylcholine
-
mutant enzyme A199S/S287G/A328W/Y332G, pH not specified in the publication, at 25C
0.072
-
Acetylcholine
-
-
0.075
-
Acetylcholine
-
mutant enzyme A199S/F227A/S287G/A328W/Y332G/E441D, pH not specified in the publication, at 25C
0.148
-
Acetylcholine
-
wild type enzyme, pH not specified in the publication, at 25C
0.08
-
acetylcholine iodide
-
fraction 13S
0.14
-
acetylcholine iodide
-
fraction 5.3S
0.019
-
Acetylthiocholine
-
pH 7.5, 25C
0.029
-
Acetylthiocholine
-
wild type enzyme, at 25C, in 0.1 M potassium phosphate, pH 7.5
0.037
-
Acetylthiocholine
-
pH 7.0, 25C, R286L mutant
0.037
-
Acetylthiocholine
-
mutant enzyme A199S/S287G/A328W/Y332G, at 25C, in 0.1 M potassium phosphate, pH 7.5
0.043
-
Acetylthiocholine
-
serum enzyme, pH 8, 25C
0.05
-
Acetylthiocholine
-
recombinant enzyme, pH 8, 25C
0.06
-
Acetylthiocholine
-
pH 7.4, 37C
0.061
-
Acetylthiocholine
-
pH 7.0, 25C, wild-type
0.08
-
Acetylthiocholine
-
pH 7.2, 27C
0.083
-
Acetylthiocholine
-
pH 7.4, 30C
0.084
-
Acetylthiocholine
-
-
0.087
-
Acetylthiocholine
-
pH 7.4, 37C
0.1
-
Acetylthiocholine
-
pH 7.5, 25C
0.13
-
Acetylthiocholine
-
-
0.13
-
Acetylthiocholine
-
pH 7.8
0.18
-
Acetylthiocholine
-
pH 7.5, 25C
0.25
-
Acetylthiocholine
-
pH 7.5, 25C
0.27
-
Acetylthiocholine
-
in 0.1 M phosphate buffer, pH 7.5, at 30C
0.47
-
Acetylthiocholine
-
pH 7.5, 25C
0.53
-
Acetylthiocholine
-
-
0.56
-
Acetylthiocholine
-
usual variant
0.71
-
Acetylthiocholine
-
fluoride resistant variant
0.96
-
Acetylthiocholine
-
atypical variant
1.2
-
Acetylthiocholine
-
pH 7.5, 25C
1.31
-
Acetylthiocholine
-
pH 7.8
3.4
-
Acetylthiocholine
-
mBuChE II
4.8
-
Acetylthiocholine
-
mBuChE I
0.057
-
acetylthiocholine iodide
-
pH 8, 37C, erythrocyte, membrane-bound form, component I
0.142
-
acetylthiocholine iodide
-
pH 7.4, 25C
0.27
-
acetylthiocholine iodide
-
pH 8, 37C, erythrocyte, membrane-bound form, component II
1.476
-
acetylthiocholine iodide
-
pH 8, 37C, erythrocyte, membrane-bound form, component III
0.003
-
Benzoylcholine
-
pH 7.4, 25C, wild-type enzyme, kinetic mechanism
0.00301
-
Benzoylcholine
-
wild-type, pH 7.4, 25C
0.005
-
Benzoylcholine
-
usual enzyme
0.008
-
Benzoylcholine
-
wild-type and A539T mutant, pH 7, 25C
0.009
-
Benzoylcholine
-
E497V/A539T mutant, pH 7, 25C
0.011
-
Benzoylcholine
-
E497V mutant, pH 7, 25C
0.021
-
Benzoylcholine
-
pH 7.4, 25C, D70G mutant
0.0211
-
Benzoylcholine
-
mutant D70G, pH 7.4, 25C
0.024
-
Benzoylcholine
-
atypical enzyme
0.047
-
Benzoylcholine
-
pH 7.4, 37C
0.00295
-
benzoylthiocholine
-
wild-type, pH 7.4, 25C
0.0084
-
benzoylthiocholine
-
pH 7.4, 25C, wild-type enzyme
0.0592
-
benzoylthiocholine
-
pH 7.4, 25C, D70G mutant
0.0592
-
benzoylthiocholine
-
mutant D70G, pH 7.4, 25C
1.22
-
beta-hydroxybutyrylcholine
-
-
0.021
-
butyryl thiocholine
-
pH 7, 22C, native and intermediate state of the enzyme
0.0256
-
butyryl thiocholine iodide
-
pH 7, mutant with only 5 N-glycosylation sites
0.29
-
Butyrylcholine
-
-
0.7
-
Butyrylcholine
-
pH 7.5, 25C
1.52
-
Butyrylcholine
-
-
7.1
-
Butyrylcholine
-
BuChE i
0.000106
-
butyrylthiocholine
Q9N1N9
pH 7.4, 37C
0.0041
-
butyrylthiocholine
-
pH 7.5, 25C
0.0052
-
butyrylthiocholine
-
pH 7.5, 25C
0.0083
-
butyrylthiocholine
-
mutant enzyme A199S/S287G/A328W/Y332G, at 25C, in 0.1 M potassium phosphate, pH 7.5
0.011
-
butyrylthiocholine
-
A328Y mutant, pH 7, 25C
0.0118
-
butyrylthiocholine
-
pH 7.0, 25C, mutant V294M
0.0169
-
butyrylthiocholine
-
pH 7.0, 25C, mutant R470W
0.017
-
butyrylthiocholine
-
A328F mutant, pH 7, 25C
0.017
-
butyrylthiocholine
-
A539T mutant, E497V/A539T mutant and E497V mutant, pH 7, 25C
0.0177
-
butyrylthiocholine
-
serum enzyme, pH 8, 25C
0.018
-
butyrylthiocholine
-
pH 7.4, 30C
0.02
-
butyrylthiocholine
-
wild-type, pH 7, 25C
0.021
-
butyrylthiocholine
-
wild type enzyme, at 25C, in 0.1 M potassium phosphate, pH 7.5
0.023
-
butyrylthiocholine
-
wild-type, pH 7, 25C
0.025
-
butyrylthiocholine
-
recombinant enzyme, pH 8, 25C
0.0273
-
butyrylthiocholine
-
pH 7.0, 25C, wild-type enzyme
0.028
-
butyrylthiocholine
-
G328G mutant, pH 7, 25C
0.0316
-
butyrylthiocholine
-
pH 7.0, 25C, mutant K12R
0.0357
-
butyrylthiocholine
-
pH 7.0, 25C, mutant G333C
0.05
-
butyrylthiocholine
-
N83A mutant, pH 7, 25C
0.06
-
butyrylthiocholine
-
N83Q and K339M mutant, pH 7, 25C
0.0689
-
butyrylthiocholine
-
pH 7.6, mean value of different animal muscle samples, overview
0.094
-
butyrylthiocholine
-
pH 7.0, 25C, R286L mutant
0.1
-
butyrylthiocholine
-
E197D and E197Q mutant, pH 7, 25C
0.1
-
butyrylthiocholine
-
incubation of butyrylthiocholine in a concentration range of 0.005-3.0 mM, with 317 pM human butyrylcholinesterase in vitro, Michaelis-Menten kinetics
0.134
-
butyrylthiocholine
-
pH 7.0, 25C, wild-type
0.15
-
butyrylthiocholine
-
pH 7.5, 25C
0.19
-
butyrylthiocholine
-
pH 7.5, 25C
0.2
-
butyrylthiocholine
-
E197G mutant, pH 7, 25C
0.2
-
butyrylthiocholine
-
pH 7.5, 25C
0.2
-
butyrylthiocholine
-
in 0.1 M phosphate buffer, pH 7.5, at 30C
0.2
-
butyrylthiocholine
-
mBuChE II
0.33
-
butyrylthiocholine
-
immobilized enzyme
0.4
-
butyrylthiocholine
-
W82A mutant, pH 7, 25C
1.4
-
butyrylthiocholine
-
pH 7.5, 25C
1.7
-
butyrylthiocholine
-
mBuChE I
1.87
-
butyrylthiocholine
-
soluble enzyme
6
-
butyrylthiocholine
-
W430A mutant, pH 7, 25C
0.03
-
butyrylthiocholine iodide
-
pH 8, 37C, liver, soluble form, component I
0.068
-
butyrylthiocholine iodide
-
pH 8, 37C, liver, membrane-bound form, component I
0.18
-
butyrylthiocholine iodide
-
pH 8, 37C, heart, soluble form, component I
0.24
-
butyrylthiocholine iodide
-
pH 8, 37C, heart, membrane-bound form, component I
0.53
-
butyrylthiocholine iodide
-
pH 8, 37C, erythrocyte, membrane-bound form, component II
0.86
-
butyrylthiocholine iodide
-
pH 8, 37C, liver, membrane-bound form, component II
0.92
-
butyrylthiocholine iodide
-
pH 8, 37C, heart, membrane-bound form, component II
1
-
butyrylthiocholine iodide
-
pH 7.6, 25C
1.46
-
butyrylthiocholine iodide
-
pH 8, 37C, liver, soluble form, component II
1.49
-
butyrylthiocholine iodide
-
pH 8, 37C, heart, soluble form, component II
2.38
-
butyrylthiocholine iodide
-
pH 8, 37C, erythrocyte, membrane-bound form, component III
2.38
-
butyrylthiocholine iodide
-
with methanolic extract of Hypnea valentine (1.3-6.5 mg/ml), Vmax: 190.9 nmole/min/mg protein
2.63
-
butyrylthiocholine iodide
-
with methanolic extract of Ulva reticulate (2-10 mg/ml), Vmax: 182.6 nmole/min/mg protein
2.77
-
butyrylthiocholine iodide
-
with methanolic extract of Dictyota dichotoma (1.3 - 6.5 mg/ml), Vmax: 232.8 nmole/min/mg protein
2.83
-
butyrylthiocholine iodide
-
with inhibitor donepezil (0.4-4.15 mg/ml), Vmax: 183.6 nmole/min/mg protein
2.87
-
butyrylthiocholine iodide
-
with methanolic extract of Enteromorpha intestinalis (1.4 - 7 mg/ml), Vmax: 192.8 nmole/min/mg protein
3.9
-
butyrylthiocholine iodide
-
Vmax: 245.6 nmole/min/mg protein
0.042
-
cocaine
-
A328W/Y332A mutant BChE
0.434
-
cocaine
-
wild-type BChE
0.76
-
crotonylcholine
-
-
1.3
-
ethylbutyrate
-
mBuChE I
8e-05
-
N-methyl-(7-dimethylcarbamoxy)quinolinium iodide
-
usual enzyme
0.002
-
N-methyl-(7-dimethylcarbamoxy)quinolinium iodide
-
atypical enzyme
0.066
-
N-methylindoxyl acetate
-
pH 7, 25C, D70G mutant
0.13
-
N-methylindoxyl acetate
-
pH 7, 25C, Y332A mutant
0.14
-
N-methylindoxyl acetate
-
pH 7, 25C, wild-type
0.162
-
N-methylindoxyl acetate
-
pH 7, 25C, D70G/Y332A mutant
0.14
-
o-nitrophenylbutyrate
-
usual and atypical enzyme
0.01
-
phenylpropionate
-
mBuChE II
0.02
-
phenylpropionate
-
mBuChE I
0.02
-
phenylthioacetate
-
mBuCh II
0.04
-
phenylthioacetate
-
mBuChE I
0.03
-
phenylthiobutyrate
-
ChE I and ChE II
0.053
-
Propionylthiocholine
-
pH 7.5, 25C
0.112
-
Propionylthiocholine
-
pH 7.0, 25C, R286L mutant
0.115
-
Propionylthiocholine
-
pH 7.4, 37C
0.18
-
Propionylthiocholine
-
pH 7.5, 25C
0.189
-
Propionylthiocholine
-
pH 7.0, 25C, wild-type
0.19
-
Propionylthiocholine
-
pH 7.5, 25C
0.19
-
Propionylthiocholine
-
in 0.1 M phosphate buffer, pH 7.5, at 30C
0.26
-
Propionylthiocholine
-
-
0.32
-
Propionylthiocholine
-
pH 7.8
0.39
-
Propionylthiocholine
-
pH 7.5, 25C
0.57
-
Propionylthiocholine
-
atypical variant
0.58
-
Propionylthiocholine
-
pH 7.5, 25C
0.7
-
Propionylthiocholine
-
fluoride resistant variant
0.76
-
Propionylthiocholine
-
usual variant
1.5
-
Propionylthiocholine
-
pH 7.5, 25C
3.19
-
Propionylthiocholine
-
pH 7.8
0.183
-
propionylthiocholine iodide
-
pH 7.4, 25C
0.5
-
propylthiocholine
-
mBuChE II
5.4
-
propylthiocholine
-
mBuChE II
0.003
-
succinylthiocholine
-
wild-type, pH 7, 25C
0.019
-
succinylthiocholine
-
K339M mutant, pH 7, 25C
11
-
succinylthiocholine
-
W430A mutant, pH 7, 25C
0.05
-
valerylthiocholine
-
mBuChE II
0.5
-
valerylthiocholine
-
mBuCh i
1.5
-
ethylbutyrate
-
mBuChE II
additional information
-
additional information
-
Km-values and kcat-values for benzoylcholine and its N-alkyl derivatives decrease as the length of the alkyl chain increases
-
additional information
-
additional information
-
structure-activity relationships and kinetic studies, overview
-
additional information
-
additional information
-
kinetics and kinetic modelling, the enzyme does not show typical Michaelis-Menten kinetics due to substrate activation at higher butyrylcholine concentration, overview
-
additional information
-
additional information
-
steady-state kinetics with aryl acetylamide substrates, overview, low affinity, first order kinetics with neutral amides
-
additional information
-
additional information
-
steady-state kinetics, overview
-
additional information
-
additional information
-
steady-state kinetics, overview
-
additional information
-
additional information
-
determination of kinetics by mass spectrometry, activity with long-chain substrates, overview
-
additional information
-
additional information
-
thermodynamics and kinetics, overview
-
additional information
-
additional information
-
kinetics of large and small fish, overview
-
additional information
-
additional information
-
kinetics of fish of both gender, overview
-
additional information
-
additional information
-
kinetics of hydrolysis of diverse esters and thioesters with various structures of alkyl bridge between esteric atom and ammonium grouping with common formula R1-(O)-XCHR2-CHR3-C by BChE, overview
-
additional information
-
additional information
-
Michaelis-Menten kinetics
-
TURNOVER NUMBER [1/s]
TURNOVER NUMBER MAXIMUM[1/s]
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.0085
-
(+)-cocaine
-
pH 7.4, 25C
0.009
-
(-)-cocaine
-
pH 7.4, 37C
0.068
-
(-)-cocaine
-
pH 7.4, wild-type enzyme
0.83
-
(-)-cocaine
-
pH 7.4, A328W mutant
1.83
-
(-)-cocaine
-
pH 7.4, Y332A mutant
2.6
-
(-)-cocaine
-
pH 7.4, A328W/Y332A mutant
2.94
-
(-)-cocaine
-
pH 7.4, Y332A mutant
6.08
-
(-)-cocaine
-
pH 7.4, A328W mutant
97
-
(R)-3-benzoyloxy-1-benzylquinuclidinium bromide
-
24C
227
-
(R)-3-benzoyloxy-1-methylquinuclidinium iodide
-
24C
3.2
-
(S)-3-benzoyloxy-1-methylquinuclidinium iodide
-
24C
250
-
2-Nitrophenyl butyrate
-
K339M mutant, pH 7, 25C
333
-
2-Nitrophenyl butyrate
-
W430A mutant, pH 7, 25C
416
-
2-Nitrophenyl butyrate
-
W82A mutant, pH 7, 25C
600
-
2-Nitrophenyl butyrate
-
wild-type, pH 7, 25C
125
-
Acetylcholine
-
mutant enzyme A199S/S287G/A328W/Y332G, pH not specified in the publication, at 25C
230
-
Acetylcholine
-
mutant enzyme A199S/F227A/S287G/A328W/Y332G/E441D, pH not specified in the publication, at 25C
243
-
Acetylcholine
-
mutant enzyme A199S/F227A/S287G/A328W/E441D, pH not specified in the publication, at 25C
1433
-
Acetylcholine
-
wild type enzyme, pH not specified in the publication, at 25C
0.005
-
Acetylthiocholine
-
pH 7.4, 37C
23.5
-
Acetylthiocholine
-
pH 7.4, 37C
160.2
-
Acetylthiocholine
-
mutant enzyme A199S/S287G/A328W/Y332G, at 25C, in 0.1 M potassium phosphate, pH 7.5
336.7
-
Acetylthiocholine
-
wild type enzyme, at 25C, in 0.1 M potassium phosphate, pH 7.5
1020
-
Acetylthiocholine
-
25C, pH 8.1
14.7
-
Benzoylcholine
-
wild-type, pH 7.4, 25C
15
-
Benzoylcholine
-
mutant D70G, pH 7.4, 25C
16.8
-
Benzoylcholine
-
pH 7.4, 37C
223
-
Benzoylcholine
-
E497V/A539T mutant, pH 7, 25C
242
-
Benzoylcholine
-
wild-type, pH 7, 25C
245
-
Benzoylcholine
-
pH 7.4, 25C, wild-type enzyme
250
-
Benzoylcholine
-
pH 7.4, 25C, D70G mutant
250
-
Benzoylcholine
-
usual and atypical enzyme
265
-
Benzoylcholine
-
A539T mutant, pH 7, 25C
303
-
Benzoylcholine
-
E497V mutant, pH 7, 25C
0.82
-
benzoylthiocholine
-
wild-type, pH 7.4, 25C
1.3
-
benzoylthiocholine
-
mutant D70G, pH 7.4, 25C
13.3
-
benzoylthiocholine
-
pH 7.4, 25C, wild-type enzyme
21.6
-
benzoylthiocholine
-
pH 7.4, 25C, D70G mutant
535
-
butyryl thiocholine iodide
-
pH 7, mutant with only 5 N-glycosylation sites
2850
-
Butyrylcholine
-
25C, pH 7.6
0.016
-
butyrylthiocholine
-
pH 5, wild-type enzyme, absence of excess substrate
0.05
-
butyrylthiocholine
-
pH 5, A328I mutant, presence of excess substrate
0.4
-
butyrylthiocholine
-
pH 5, A328W and E197Q mutant, absence of excess substrate
2
-
butyrylthiocholine
-
W82A mutant, pH 7, 25C
2
-
butyrylthiocholine
-
pH 5, L286W mutant, absence of excess substrate
20.5
-
butyrylthiocholine
-
pH 5, A328I mutant, absence of excess substrate
22.3
-
butyrylthiocholine
-
pH 5, A328G mutant, absence of excess substrate
41.4
-
butyrylthiocholine
-
pH 5, Y332A mutant, presence of excess substrate
46.67
-
butyrylthiocholine
-
mutant enzyme A199S/S287G/A328W/Y332G, at 25C, in 0.1 M potassium phosphate, pH 7.5
46.7
-
butyrylthiocholine
-
pH 5, wild-type enzyme, absence of excess substrate
48.3
-
butyrylthiocholine
-
pH 5, Y332A mutant, absence of excess substrate
53.3
-
butyrylthiocholine
-
pH 5, A328W and E197Q mutant, absence of excess substrate
67
-
butyrylthiocholine
-
E197D mutant, pH 7, 25C
71.7
-
butyrylthiocholine
-
pH 5, L286W mutant, absence of excess substrate
83
-
butyrylthiocholine
-
W430A mutant, pH 7, 25C
98
-
butyrylthiocholine
-
pH 7.0, 25C, mutant G333C
105
-
butyrylthiocholine
-
pH 5, V288W mutant, absence of excess substrate
110
-
butyrylthiocholine
-
pH 5, A328F mutant, absence of excess substrate
150
-
butyrylthiocholine
-
E197Q mutant, pH 7, 25C
250
-
butyrylthiocholine
-
K339M mutant, pH 7, 25C
290
-
butyrylthiocholine
-
pH 5, L286W mutant, presence of excess substrate
333
-
butyrylthiocholine
-
G328G mutant, pH 7, 25C
338
-
butyrylthiocholine
-
pH 7.0, 25C, mutant V294M
450
-
butyrylthiocholine
-
wild-type, pH 7, 25C
490
-
butyrylthiocholine
-
pH 7.0, 25C, mutant R470W
491.7
-
butyrylthiocholine
-
wild type enzyme, at 25C, in 0.1 M potassium phosphate, pH 7.5
500
-
butyrylthiocholine
-
pH 7.0, 25C, wild-type enzyme
508
-
butyrylthiocholine
-
E497V/A539T mutant, pH 7, 25C
533
-
butyrylthiocholine
-
A328F mutant, pH 7, 25C
542
-
butyrylthiocholine
-
A539T mutant and E497V mutant, pH 7, 25C
565
-
butyrylthiocholine
-
wild-type, pH 7, 25C
585
-
butyrylthiocholine
-
pH 7.0, 25C, mutant K12R
617
-
butyrylthiocholine
-
N83A mutant, pH 7, 25C
667
-
butyrylthiocholine
-
A328Y mutant, pH 7, 25C
767
-
butyrylthiocholine
-
N83Q mutant, pH 7, 25C
920
-
butyrylthiocholine
-
pH 5, A328F mutant, presence of excess substrate
1048
-
butyrylthiocholine
-
pH 5, V288W mutant, presence of excess substrate
1050
-
butyrylthiocholine
-
pH 5, V288W mutant, presence of excess substrate
386.8
-
cocaine
-
A328W/Y332A mutant BChE
4.17e-05
-
N-methyl-(7-dimethylcarbamoxy)quinolinium iodide
-
usual and atypical enzyme
200
-
N-methylindoxyl acetate
-
pH 7, 25C, Y332A mutant
250
-
N-methylindoxyl acetate
-
pH 7, 25C, D70G/Y332A mutant
300
-
N-methylindoxyl acetate
-
pH 7, 25C, D70G mutant; pH 7, 25C, wild-type
800
-
o-nitrophenylbutyrate
-
usual and atypical enzyme
49.2
-
Propionylthiocholine
-
pH 7.4, 37C
3350
-
Propionylthiocholine
-
pH 7.0, 25C
3
-
succinylthiocholine
-
K339M and W430A mutant, pH 7, 25C
6
-
succinylthiocholine
-
wild-type, pH 7, 25C
418.3
-
cocaine
-
wild-type BChE
additional information
-
additional information
-
Km-values and kcat-values for benzoylcholine and its N-alkyl derivatives decrease as the length of the alkyl chain increases
-
kcat/KM VALUE [1/mMs-1]
kcat/KM VALUE [1/mMs-1] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
3000
-
Acetylcholine
-
mutant enzyme A199S/F227A/S287G/A328W/Y332G/E441D, pH not specified in the publication, at 25C
6308
3500
-
Acetylcholine
-
mutant enzyme A199S/S287G/A328W/Y332G, pH not specified in the publication, at 25C
6308
9000
-
Acetylcholine
-
mutant enzyme A199S/F227A/S287G/A328W/E441D, pH not specified in the publication, at 25C
6308
9667
-
Acetylcholine
-
wild type enzyme, pH not specified in the publication, at 25C
6308
4333
-
Acetylthiocholine
-
mutant enzyme A199S/S287G/A328W/Y332G, at 25C, in 0.1 M potassium phosphate, pH 7.5
6332
11500
-
Acetylthiocholine
-
wild type enzyme, at 25C, in 0.1 M potassium phosphate, pH 7.5
6332
23330
-
butyrylthiocholine
-
mutant enzyme A199S/S287G/A328W/Y332G, at 25C, in 0.1 M potassium phosphate, pH 7.5
20340
56670
-
butyrylthiocholine
-
wild type enzyme, at 25C, in 0.1 M potassium phosphate, pH 7.5
20340
Ki VALUE [mM]
Ki VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.0085
-
(+)-cocaine
-
pH 7.4, 25C
0.009
-
(-)-cocaine
-
pH 7.4, 37C
0.0008
-
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
pH 8, 25C, Q119Y/V288F/A328Y mutant
0.00111
-
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
pH 8, 25C, wild-type enzyme
0.0024
-
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
pH 8, 25C, A277W mutant
0.0035
-
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
pH 8, 25C, V288F mutant
0.0039
-
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
pH 8, 25C, A328Y mutant
0.0129
-
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
pH 8, 25C, Q119Y mutant
0.0228
-
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
pH 8, 25C, A328F mutant
0.03
-
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
pH 8, 25C, D70G mutant
0.12
-
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
pH 8, 25C, W82A mutant
0.0033
-
(S)-3-benzoyloxy-1-benzylquinuclidinium bromide
-
24C
0.00633
-
10-(2,2-dimethylpropanoyl)-10H-phenothiazine
-
pH 8.0, 23C
0.00643
-
10-(2-ethylbutanoyl)-10H-phenothiazine
-
pH 8.0, 23C
0.00359
-
10-(3,3-dimethylbutanoyl)-10H-phenothiazine
-
pH 8.0, 23C
0.00646
-
10-(3-methylbutanoyl)-10H-phenothiazine
-
pH 8.0, 23C
0.0109
-
10-(chloroacetyl)-10H-phenothiazine
-
pH 8.0, 23C
0.0048
-
10-(cyclobutylcarbonyl)-10H-phenothiazine
-
pH 8.0, 23C
0.00086
-
10-(cycloheptylcarbonyl)-10H-phenothiazine
-
pH 8.0, 23C
0.00168
-
10-(cyclohexylacetyl)-10H-phenothiazine
-
pH 8.0, 23C
0.00126
-
10-(cyclohexylcarbonyl)-10H-phenothiazine
-
pH 8.0, 23C
0.00222
-
10-(cyclopentylacetyl)-10H-phenothiazine
-
pH 8.0, 23C
0.00421
-
10-(cyclopentylcarbonyl)-10H-phenothiazine
-
pH 8.0, 23C
0.0231
-
10-(cyclopropylcarbonyl)-10H-phenothiazine
-
pH 8.0, 23C
0.0296
-
10-(methoxyacetyl)-10H-phenothiazine
-
pH 8.0, 23C
0.0358
-
10-acetyl-10H-phenothiazine
-
pH 8.0, 23C
0.0162
-
10-butyryl-10H-phenothiazine
-
pH 8.0, 23C
0.00831
-
10-heptanoyl-10H-phenothiazine
-
pH 8.0, 23C
0.00637
-
10-hexanoyl-10H-phenothiazine
-
pH 8.0, 23C
0.0132
-
10-isobutyryl-10H-phenothiazine
-
pH 8.0, 23C
0.0102
-
10-pentanoyl-10H-phenothiazine
-
pH 8.0, 23C
0.0256
-
10-propionyl-10H-phenothiazine
-
pH 8.0, 23C
0.34
-
2-((Z)-(hydroxyimino)methyl)-1-methylpyridinium chloride
-
pH 7.0, 25C
0.0032
-
2-(1-piperidinyl)ethyl phenothiazine carbamate
-
23C
0.00065
-
2-(1-pyrrolidinyl)ethyl phenothiazine carbamate
-
23C
0.0024
-
2-(4-morpholino)ethyl phenothiazine carbamate
-
23C
0.0006
-
2-(diethylamino)ethyl 10H-phenothiazine-10-carboxylate
-
23C
0.0025
-
2-(dimethylamino)ethyl 10H-phenothiazine-10-carboxylate
-
23C
0.0017
-
2-(trifluoromethyl)phenyl butylcarbamate
-
pH 7.0, 25C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 0.11
0.013
-
2-chlorophenyl butylcarbamate
-
pH 7.0, 25C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 0.6
0.0042
-
2-ethylphenyl butylcarbamate
-
pH 7.0, 25C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 0.4
0.017
-
2-methoxyphenyl butylcarbamate
-
pH 7.0, 25C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 2.5
0.011
-
2-methylphenyl butylcarbamate
-
pH 7.0, 25C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 1.1
0.0007
-
2-nitrophenyl butylcarbamate
-
pH 7.0, 25C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 0.04
0.022
-
2-tert-butoxyphenyl butylcarbamate
-
pH 7.0, 25C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 4
0.00074
-
3-(diethylamino)propyl 10H-phenothiazine-10-carboxylate
-
23C
0.027
-
4-(aminocarbonyl)-1-(((2-((Z)-(hydroxyimino)methyl)pyridinium-1-yl)methoxy)methyl)pyridinium dichloride
-
pH 7.0, 25C
0.00064
-
7(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
pH 8, 25C
0.00011
-
amlodipine
-
-
0.00011
-
amlodipine besylate
-
-
0.0374
-
apigenin
-
-
0.0032
-
Benzoylcholine
-
37C
0.007
-
Benzoylcholine
-
45C
0.011
-
biphenyl-2-yl butylcarbamate
-
pH 7.0, 25C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 1.0
0.05
-
butyrylthiocholine
-
-
0.0003
-
Chlordiazepoxide
-
-
0.0003
-
chlordiazepoxide HCl
-
-
0.0322
-
Chlorpromazine
-
pH 8.0, 23C
11
-
choline
-
37C
15.89
-
choline
-
45C
0.0032
-
cyclopentyl phenothiazine carbamate
-
23C
38
-
cymserine
-
pH 7.0, 25C
4.3e-05
-
diazepam
-
-
8.8e-07
-
eserine
-
22C
1.74e-06
-
eserine
-
22C
5e-05
-
ethopropazine
-
pH 8.0, 25C
0.000166
-
ethopropazine
-
pH 8.0, 23C
0.0234
-
ethyl carbamate
-
23C
7.1e-06
-
ethyl carbamoyl
-
22C
2.3e-05
-
ethyl carbamoyl
-
22C
0.09
-
fisetin
-
-
0.0069
-
galangin
-
-
0.0019
-
hydralazine
-
-
0.0019
-
hydralazine HCl
-
-
0.000306
-
iprobenfos
-
pH 7.6, mean value of different animal muscle samples, overview
0.0181
-
iso-propyl carbamate
-
23C
0.127
-
K074
-
-
0.338
-
K075
-
-
0.059
-
K114
-
-
0.043
-
kaempferol
-
-
0.0011
-
lovastatin
-
-
0.166
-
luteolin
-
-
0.00028
-
malachite green
-
25C, pH 8.0
0.00046
-
malachite green
-
pH 8.0, 25C
0.00044
-
meldola blue
-
pH 8.0, 25C
0.0102
-
methyl carbamate
-
23C
0.00012
-
methyl green
-
25C, pH 8.0
0.00041
-
methyl green
-
pH 8.0, 25C
0.00111
-
methylene blue
-
pH 8.0, 25C
0.071
-
myricetin
-
-
0.0134
-
n-butyl carbamate