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EC Tree
The enzyme appears in viruses and cellular organisms
Synonyms
lactonase, actinomycin,
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lactonase, actinomycin
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actinomycin + H2O = actinomycinic monolactone
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hydrolysis of carboxylic ester
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actinomycin lactonohydrolase
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actinomycin + H2O
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degradation
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actinomycin + H2O
actinomycinic monolactone
actinomycin + H2O
actinomycinic monolactone
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actinomycin + H2O
actinomycinic monolactone
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actinomycin + H2O
actinomycinic monolactone
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not: other peptide lactone antibiotics, staphylomycin S, vernamycin B alpha, echinomycin, etamycin, stendomycin
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actinomycin + H2O
actinomycinic monolactone
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actinomycin + H2O
actinomycinic monolactone
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actinomycin + H2O
actinomycinic monolactone
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actinomycin + H2O
actinomycinic monolactone
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actinomycin + H2O
actinomycinic monolactone
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actinomycin + H2O
actinomycinic monolactone
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actinomycin + H2O
actinomycinic monolactone
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actinomycin + H2O
actinomycinic monolactone
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actinomycin + H2O
actinomycinic monolactone
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actinomycin + H2O
actinomycinic monolactone
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actinomycin + H2O
actinomycinic monolactone
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actinomycin + H2O
actinomycinic monolactone
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actinomycin + H2O
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degradation
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additional information
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0.5 mg product formed per 60 min per mg of protein
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additional information
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energy of activation: 15.9 kcal
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59000
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sedimentation equilibrium centrifugation
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4°C, 0.05 M potassium phosphate buffer, pH 7.0, 1 week stable
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Perlman, D.
Actinomycin lactonase
Methods Enzymol.
43
763-767
1975
Actinoplanes missouriensis
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Hou, C.T.; Perlman, D.
Microbial transformations of peptide antibiotics. V. Purification and properties of the actinomycin lactonase from Actinoplanes missouriensis
J. Biol. Chem.
245
1289-1295
1970
Actinoplanes missouriensis
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Mehta, R.J.; Fare, L.R.; Newman, D.J.; Nash, C.H.
Actinomycin D inactivating enzymes from Actinoplanes missouriensis and several other members of the Actinoplanaceae family
Eur. J. Appl. Microbiol. Biotechnol.
5
165-170
1978
Actinoplanes missouriensis, Dactylosporangium aurantiacum, Dactylosporangium thailandense, Streptomyces purpureus, Planobispora longispora, Planobispora rosea, Spirillospora albida, Spirillospora sp., Kutzneria albida, Streptosporangium brasiliense, Streptosporangium roseum, Streptosporangium violaceochromogenes, Kutzneria viridogrisea
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