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(S)-5-oxo-2-tetrahydrofurancarboxylic acid + H2O
L-alpha-hydroxyglutaric acid
-
-
-
-
?
6-phospho-D-glucono-1,4-lactone + H2O
6-phospho-D-gluconate
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
D-glucono-delta-lactone + H2O
?
-
-
-
-
?
delta-6 phosphogluconolactone + H2O
6-phosphogluconic acid
-
-
-
?
additional information
?
-
6-phospho-D-glucono-1,4-lactone + H2O
6-phospho-D-gluconate
the gamma-lactone is more stable than the natural delta-lactone substrate. It contains a five-membered heterocyclic ring, whereas the delta-lactone contains a six-membered heterocyclic ring
-
-
?
6-phospho-D-glucono-1,4-lactone + H2O
6-phospho-D-gluconate
-
the gamma-lactone is more stable than the natural delta-lactone substrate. It contains a five-membered heterocyclic ring, whereas the delta-lactone contains a six-membered heterocyclic ring
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phospho-D-gluconate
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phosphogluconolactone
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
ir
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phospho-D-gluconate
-
ir
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
ir
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phospho-D-gluconate
-
ir
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
ir
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phosphogluconolactone
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phosphogluconolactone
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
enzyme hydrolyzes both, the delta- and - gamma forms of 6-phosphogluconolactone
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phospho-D-gluconate
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
second step in pentose phosphate pathway
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
second step in pentose phosphate pathway
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
second step in pentose phosphate pathway
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phospho-D-gluconate
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phospho-D-gluconate
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phospho-D-gluconate
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
ir
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phosphogluconolactone
-
ir
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phospho-D-gluconate
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phosphogluconolactone
-
ir
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
H165 is the catalytic residue, while R77 and R200 bind to the phosphate group. Ring opening of the lactone involves proton transfer from HE2 of H165 to O1 or O5 of the lactone, via a water molecule
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phosphoglucono-delta-lactone is unstable and hydrolyzes spontaneously to the open-chain 6-phosphogluconate
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phosphoglucono-delta-lactone is unstable and hydrolyzes spontaneously to the open-chain 6-phosphogluconate
-
?
additional information
?
-
-
independence of glycolytic and pentose cycle intermediates in ad libitum fed rats
-
-
?
additional information
?
-
-
induction of 6-phosphogluconolactonase, phosphogluconate dehydrogenase and gluconokinase, enzymes of the oxidative pentose phosphate pathway by glucono-delta-lactone
-
-
?
additional information
?
-
-
induction of 6-phosphogluconolactonase, phosphogluconate dehydrogenase and gluconokinase, enzymes of the oxidative pentose phosphate pathway by glucono-delta-lactone
-
-
?
additional information
?
-
-
the enzyme is involved in the second step of the pentose phosphate pathway
-
-
?
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Cronin, C.N.; Nolan, D.P.; Voorheis, H.P.
The enzymes of the classical pentose phosphate pathway display differential activities in procyclic and bloodstream forms of Trypanosoma brucei
FEBS Lett.
244
26-30
1989
Trypanosoma brucei
brenda
Kawada, M.; Kawada, Y.; Takiguchi, H.; Shimazono, N.
Purification of 6-phosphogluconolactonase from rat liver and yeast; its separation from gluconolactonase
Biochim. Biophys. Acta
57
404-407
1962
Rattus norvegicus, Saccharomyces cerevisiae
brenda
Kupor, S.R.; Fraenkel, D.G.
6-Phosphogluconolactonase mutants of Escherichia coli and a maltose blue gene
J. Bacteriol.
100
1296-1301
1969
Escherichia coli, Escherichia coli K-10
brenda
Kupor, S.R.; Fraenkel, D.G.
Glucose metabolism in 6 phosphogluconolactonase mutants of Escherichia coli
J. Biol. Chem.
247
1904-1910
1972
Escherichia coli, Escherichia coli DF 2000, Escherichia coli K-10
brenda
Schofield, P.J.; Sols, A.
Rat liver 6-phosphogluconolactonase: a low Km enzyme
Biochem. Biophys. Res. Commun.
71
1313-1318
1976
Rattus norvegicus
brenda
Bauer, H.P.; Srihari, T.; Jochims, J.C.; Hofer, H.W.
6-Phosphogluconolactonase. Purification, properties and activities in various tissues
Eur. J. Biochem.
133
163-168
1983
Bos taurus, Homo sapiens, Rattus norvegicus
brenda
Scopes, R.K.
6-Phosphogluconolactonase from Zymomonas mobilis
FEBS Lett.
193
185-188
1985
Zymomonas mobilis, Zymomonas mobilis ATCC 31821
-
brenda
Casazza, J.P.; Veech, R.L.
The interdependence of glycolytic and pentose cycle intermediates in ad libitum fed rats
J. Biol. Chem.
261
690-698
1986
Rattus norvegicus
brenda
Beutler, E.; Kuhl, W.; Gelbart, T.
Blood cell phosphogluconolactonase: assay and properties
Br. J. Haematol.
62
577-586
1986
Homo sapiens
brenda
Hofer, H.W.; Bauer, H.P.
6-Phosphogluconolactonase
Cell Biochem. Funct.
5
97-99
1987
Bos taurus, Saccharomyces cerevisiae, Rattus norvegicus
brenda
Moir, R.D.; Stokes, G.B.
A spectrophotometric assay for 6-phosphogluconolactonase involving the use of immobilized enzymes to prepare the labile 6-phosphoglucono-delta-lactone substrate
Biochem. J.
256
69-73
1988
Saccharomyces cerevisiae
brenda
Medina-Puerta, M.M.; Gallego-Iniesta, M.; Garrido-Pertierra, A.
Kinetic properties from bass liver 6-phosphogluconolactonase
Biochem. Int.
16
571-578
1988
Dicentrarchus labrax
brenda
Medina-Puerta, M.M.; Gallego-Iniesta, M.; Garrido-Pertierra, A.
Purification of 6-phosphogluconolactonase from bass (Dicentrarchus labrax L.) liver
Biochem. Int.
17
1011-1019
1988
Dicentrarchus labrax
brenda
Sinha, A.; Maitra, P.K.
Induction of specific enzymes of the oxidative pentose phosphate pathway by glucono-delta-lactone in Saccharomyces cerevisiae
J. Gen. Microbiol.
138
1865-1873
1992
Saccharomyces cerevisiae, Saccharomyces cerevisiae MC3
brenda
Rakitzis, E.T.; Papandreou, P.
Kinetic analysis of 6-phosphogluconolactone hydrolysis in hemolysates
Biochem. Mol. Biol. Int.
37
747-755
1995
Homo sapiens
brenda
Collard, F.; Collet, J.F.; Gerin, I.; Veiga-da-Cunha, M.; van Schaftingen, E.
Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway(1)
FEBS Lett.
459
223-226
1999
Homo sapiens
brenda
Clarke, J.L.; Mason, P.J.
Murine hexose-6-phosphate dehydrogenase: a bifunctional enzyme with broad substrate specificity and 6-phosphogluconolactonase activity
Arch. Biochem. Biophys.
415
229-234
2003
Mus musculus
brenda
Clarke, J.L.; Scopes, D.A.; Sodeinde, O.; Mason, P.J.
Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase. A novel bifunctional enzyme in malaria parasites
Eur. J. Biochem.
268
2013-2019
2001
Homo sapiens, Plasmodium berghei
brenda
Hager, P.W.; Calfee, M.W.; Phibbs, P.V.
The Pseudomonas aeruginosa devB/SOL homolog, pgl, is a member of the hex regulon and encodes 6-phosphogluconolactonase
J. Bacteriol.
182
3934-3941
2000
Pseudomonas aeruginosa (Q9X2N2), Pseudomonas aeruginosa
brenda
Duffieux, F.; Van Roy, J.; Michels, P.A.; Opperdoes, F.R.
Molecular characterization of the first two enzymes of the pentose-phosphate pathway of Trypanosoma brucei. Glucose-6-phosphate dehydrogenase and 6-phosphogluconolactonase
J. Biol. Chem.
275
27559-27565
2000
Trypanosoma brucei (Q9GRG6), Trypanosoma brucei
brenda
Miclet, E.; Stoven, V.; Michels, P.A.M.; Opperdoes, F.R.; Lallemand, J.Y.; Duffieux, F.
NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase
J. Biol. Chem.
276
34840-34846
2001
Homo sapiens (O95336), Homo sapiens, Plasmodium falciparum (Q27741), Plasmodium falciparum, Trypanosoma brucei (Q9GRG6), Trypanosoma brucei
brenda
Clarke, J.L.; Sodeinde, O.; Mason, P.J.
A unique insertion in Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase: evolutionary and functional studies
Mol. Biochem. Parasitol.
127
1-8
2003
Plasmodium berghei
brenda
Zimenkov, D.; Gulevich, A.; Skorokhodova, A.; Biriukova, I.; Kozlov, Y.; Mashko, S.
Escherichia coli ORF ybhE is pgl gene encoding 6-phosphogluconolactonase (EC 3.1.1.31) that has no homology with known 6PGLs from other organisms
FEMS Microbiol. Lett.
244
275-280
2005
Escherichia coli
brenda
Thomason, L.C.; Court, D.L.; Datta, A.R.; Khanna, R.; Rosner, J.L.
Identification of the Escherichia coli K-12 ybhE gene as pgl, encoding 6-phosphogluconolactonase
J. Bacteriol.
186
8248-8253
2004
Escherichia coli
brenda
Crooke, A.; Diez, A.; Mason, P.J.; Bautista, J.M.
Transient silencing of Plasmodium falciparum bifunctional glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
FEBS J.
273
1537-1546
2006
Plasmodium falciparum
brenda
Delarue, M.; Duclert-Savatier, N.; Miclet, E.; Haouz, A.; Giganti, D.; Ouazzani, J.; Lopez, P.; Nilges, M.; Stoven, V.
Three dimensional structure and implications for the catalytic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei
J. Mol. Biol.
366
868-881
2007
Trypanosoma brucei (Q385D6), Trypanosoma brucei
brenda
Hong, M.K.; Kim, J.K.; Kim, H.; Jung, J.; Ahn, Y.J.; Kim, J.G.; Lee, B.M.; Kang, L.W.
Expression, crystallization and preliminary X-ray crystallographic analysis of Xoo2316, a predicted 6-phosphogluconolactonase, from Xanthomonas oryzae pv. oryzae
Acta Crystallogr. Sect. F
64
1016-1018
2008
Xanthomonas oryzae
brenda
Tarighi, S.; Wei, Q.; Camara, M.; Williams, P.; Fletcher, M.P.; Kajander, T.; Cornelis, P.
The PA4204 gene encodes a periplasmic gluconolactonase (PpgL) which is important for fitness of Pseudomonas aeruginosa
Microbiology
154
2979-2990
2008
Pseudomonas aeruginosa
brenda
Crimmins, G.T.; Schelle, M.W.; Herskovits, A.A.; Ni, P.P.; Kline, B.C.; Meyer-Morse, N.; Iavarone, A.T.; Portnoy, D.A.
Listeria monocytogenes 6-phosphogluconolactonase mutants induce increased activation of a host cytosolic surveillance pathway
Infect. Immun.
77
3014-3022
2009
Listeria monocytogenes
brenda
Duclert-Savatier, N.; Poggi, L.; Miclet, E.; Lopes, P.; Ouazzani, J.; Chevalier, N.; Nilges, M.; Delarue, M.; Stoven, V.
Insights into the enzymatic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei using structural data and molecular dynamics simulation
J. Mol. Biol.
388
1009-1021
2009
Trypanosoma brucei
brenda
Xiong, Y.; DeFraia, C.; Williams, D.; Zhang, X.; Mou, Z.
Characterization of Arabidopsis 6-phosphogluconolactonase T-DNA insertion mutants reveals an essential role for the oxidative section of the plastidic pentose phosphate pathway in plant growth and development
Plant Cell Physiol.
50
1277-1291
2009
Arabidopsis thaliana (Q84WW2), Arabidopsis thaliana (Q8LEV7), Arabidopsis thaliana (Q8LG70), Arabidopsis thaliana (Q9FIN1), Arabidopsis thaliana (Q9LMX8)
brenda
Jortzik, E.; Mailu, B.M.; Preuss, J.; Fischer, M.; Bode, L.; Rahlfs, S.; Becker, K.
Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase: a unique bifunctional enzyme from Plasmodium falciparum
Biochem. J.
436
641-650
2011
Plasmodium falciparum, Homo sapiens (O95336), Homo sapiens
brenda
Hoelscher, C.; Meyer, T.; Von Schaewen, A.
Dual-targeting of Arabidopsis 6-phosphogluconolactonase 3 (PGL3) to chloroplasts and peroxisomes involves interaction with Trx m2 in the cytosol
Mol. Plant
7
252-255
2014
Arabidopsis thaliana
brenda
Calligari, P.A.; Salgado, G.F.; Pelupessy, P.; Lopes, P.; Ouazzani, J.; Bodenhausen, G.; Abergel, D.
Insights into internal dynamics of 6-phosphogluconolactonase from Trypanosoma brucei studied by nuclear magnetic resonance and molecular dynamics
Proteins
80
1196-1210
2012
Trypanosoma brucei
brenda
Allen, S.M.; Lim, E.E.; Jortzik, E.; Preuss, J.; Chua, H.H.; MacRae, J.I.; Rahlfs, S.; Haeussler, K.; Downton, M.T.; McConville, M.J.; Becker, K.; Ralph, S.A.
Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase is a potential drug target
FEBS J.
282
3808-3823
2015
Plasmodium falciparum (Q8IKU0), Plasmodium falciparum
brenda
Holt, J.; Kiedrowski, M.; Frank, K.; Du, J.; Guan, C.; Broderick, N.; Dunny, G.; Handelsman, J.
Enterococcus faecalis 6-phosphogluconolactonase is required for both commensal and pathogenic interactions with Manduca sexta
Infect. Immun.
83
396-404
2015
Enterococcus faecalis
brenda
Morales-Luna, L.; Serrano-Posada, H.; Gonzalez-Valdez, A.; Ortega-Cuellar, D.; Vanoye-Carlo, A.; Hernandez-Ochoa, B.; Sierra-Palacios, E.; Rufino-Gonzalez, Y.; Castillo-Rodriguez, R.A.; Perez de la Cruz, V.; Moreno-Vargas, L.; Prada-Gracia, D.; Marcial-Quino, J.; Gomez-Manzo, S.
Biochemical characterization and structural modeling of fused glucose-6-phosphate dehydrogenase-phosphogluconolactonase from Giardia lamblia
Int. J. Mol. Sci.
19
2518
2018
Giardia intestinalis (A8BWM5), Giardia intestinalis, Giardia intestinalis ATCC 50803 (A8BWM5)
brenda