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Disease on EC 2.7.7.B22 - transposase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Two frameshift products involved in the transposition of bacterial insertion sequence IS629.
Adenocarcinoma
HNF4alpha expression amplifies the glucocorticoid-induced conversion of a human pancreatic cell line to an hepatocyte-like cell.
Anaplasmosis
Transformation of Anaplasma marginale.
Anemia, Sickle Cell
Quantitative real-time polymerase chain reaction (qRT-PCR) restriction fragment length polymorphism (RFLP) method for monitoring highly conserved transgene expression during gene therapy.
Arthritis
Coxiella burnetii, the agent of Q fever in Brazil: its hidden role in seronegative arthritis and the importance of molecular diagnosis based on the repetitive element IS1111 associated with the transposase gene.
Atherosclerosis
Relations between cardiovascular risk estimates and subclinical atherosclerosis in naive HIV patients: results from the HERMES study.
Sleeping Beauty Transposon Vectors in Liver-directed Gene Delivery of LDLR and VLDLR for Gene Therapy of Familial Hypercholesterolemia.
Atrial Fibrillation
Effect of atrial fibrillation on endovascular thrombectomy for acute ischemic stroke. A meta-analysis of individual patient data from six randomised trials: Results from the HERMES collaboration.
The associations of plasma phospholipid arachidonic acid with cardiovascular diseases: A Mendelian randomization study.
beta-Thalassemia
In Vivo HSC Gene Therapy Using a Bi-modular HDAd5/35++ Vector Cures Sickle Cell Disease in a Mouse Model.
Brain Edema
Cerebral Edema in Patients With Large Hemispheric Infarct Undergoing Reperfusion Treatment: A HERMES Meta-Analysis.
Brain Neoplasms
The contribution of tumor and host tissue factor expression to oncogene-driven gliomagenesis.
Brucellosis
Comparative application of IS711-based polymerase chain reaction (PCR) and loop-mediated isothermal amplification (LAMP) for canine brucellosis diagnosis.
Comparative study of IS711 and bcsp31-based polymerase chain reaction (PCR) for the diagnosis of human brucellosis in whole blood and serum samples.
Comparison of conventional and non-conventional techniques for the diagnosis of bovine brucellosis in Sudan.
IS711-based real-time PCR assay as a tool for detection of Brucella spp. in wild boars and comparison with bacterial isolation and serology.
Large-scale evaluation of a single-tube nested PCR for the laboratory diagnosis of human brucellosis in Kuwait.
Carcinoma
An efficient Screening System in Yeast to Select a Hyperactive piggyBac Transposase for Mammalian Applications.
Counterselection and co-delivery of transposon and transposase functions for Sleeping Beauty-mediated transposition in cultured mammalian cells.
Carcinoma, Hepatocellular
Counterselection and co-delivery of transposon and transposase functions for Sleeping Beauty-mediated transposition in cultured mammalian cells.
Cardiovascular Diseases
Relations between cardiovascular risk estimates and subclinical atherosclerosis in naive HIV patients: results from the HERMES study.
Cerebral Hemorrhage
Feasibility, Safety, and Outcome of Endovascular Recanalization in Childhood Stroke: The Save ChildS Study.
Cerebral Infarction
#Fake news: a systematic review of mechanical thrombectomy results among neurointerventional stroke surgeons on Twitter.
Cockayne Syndrome
PGBD5: a neural-specific intron-containing piggyBac transposase domesticated over 500 million years ago and conserved from cephalochordates to humans.
Colonic Neoplasms
Mutation and expression alterations of histone methylation-related NSD2, KDM2B and SETMAR genes in colon cancers.
Potential role for the Metnase transposase fusion gene in colon cancer through the regulation of key genes.
Study of the interaction among Notch pathway receptors, correlation with stemness, as well as their interaction with CD44, dipeptidyl peptidase-IV, hepatocyte growth factor receptor and the SETMAR transferase, in colon cancer stem cells.
Colorectal Neoplasms
CD44 participates in the adhesion of human colorectal carcinoma cells to laminin and type IV collagen.
Coma
A novel peptidoglycan-linked lipoprotein (ComL) that functions in natural transformation competence of Neisseria gonorrhoeae.
COVID-19
Generation of a Sleeping Beauty Transposon-Based Cellular System for Rapid and Sensitive Screening for Compounds and Cellular Factors Limiting SARS-CoV-2 Replication.
Crohn Disease
Graph mining for next generation sequencing: leveraging the assembly graph for biological insights.
Cystic Fibrosis
Report of the European Respiratory Society/European Cystic Fibrosis Society task force on the care of adults with cystic fibrosis.
Decompression Sickness
European EVA decompression sickness risks.
Diabetes Mellitus, Type 2
The Proton-Coupled Monocarboxylate Transporter Hermes Is Necessary for Autophagy during Cell Death.
Ehrlichiosis
Ehrlichia Isolate from a Minnesota Tick: Characterization and Genetic Transformation.
Epilepsy
Validating Patient-Specific Finite Element Models of Direct Electrocortical Stimulation.
Foot-and-Mouth Disease
A recombinant truncated FMDV 3AB protein used to better distinguish between infected and vaccinated cattle.
Genetic Diseases, Inborn
The Sleeping Beauty Transposon Vector System for Treatment of Rare Genetic Diseases: an Unrealized Hope?
Glioblastoma
SETMAR isoforms in glioblastoma: A matter of protein stability.
Glioma
Early modification of host cell gene expression induced by HIV-1.
GSH and GABA decreases in IDH1-mutated low-grade gliomas detected by HERMES spectral editing at 3 T in vivo.
Therapeutic Efficacy of Immune Stimulatory Thymidine Kinase and fms-like Tyrosine Kinase 3 Ligand (TK/Flt3L) Gene Therapy in a Mouse Model of High-Grade Brainstem Glioma.
Gonadal Dysgenesis
A hobo transgene that encodes the P-element transposase in Drosophila melanogaster: autoregulation and cytotype control of transposase activity.
Heart Diseases
Possible plaque buster offers new hope. HDL could become a treatment for heart disease.
The associations of plasma phospholipid arachidonic acid with cardiovascular diseases: A Mendelian randomization study.
Heart Failure
A study of risk factors and complications in elderly hypertensive subjects.
Daily home monitoring of potassium, creatinine, and estimated plasma volume in heart failure post-discharge.
The genomics of heart failure: design and rationale of the HERMES consortium.
Hematologic Neoplasms
Delineation of Known and New Transcript Variants of the SETMAR (Metnase) Gene and the Expression Profile in Hematological Neoplasms.
Hemophilia A
Nanocapsule-delivered Sleeping Beauty mediates therapeutic Factor VIII expression in liver sinusoidal endothelial cells of hemophilia A mice.
Hemophilia B
Hyperactive sleeping beauty transposase enables persistent phenotypic correction in mice and a canine model for hemophilia B.
Integration profile and safety of an adenovirus hybrid-vector utilizing hyperactive sleeping beauty transposase for somatic integration.
Hemorrhagic Septicemia, Viral
Dual functionality of lamprey VLRB C-terminus (LC) for multimerization and cell surface display.
Herpes Simplex
Herpes Simplex Virus/Sleeping Beauty Vector-Based Embryonic Gene Transfer Using the HSB5 Mutant: Loss of Apparent Transposition Hyperactivity In Vivo.
Vector modifications to eliminate transposase expression following piggyBac-mediated transgenesis.
HIV Infections
Is metabolic syndrome associated to HIV infection per se? Results from the HERMES study.
Relations between cardiovascular risk estimates and subclinical atherosclerosis in naive HIV patients: results from the HERMES study.
Hypersensitivity
Characterization of the accessible genome in the human malaria parasite Plasmodium falciparum.
Relations between cardiovascular risk estimates and subclinical atherosclerosis in naive HIV patients: results from the HERMES study.
Hypertension
A study of risk factors and complications in elderly hypertensive subjects.
Infections
A High-Capacity Adenoviral Hybrid Vector System Utilizing the Hyperactive Sleeping Beauty Transposase SB100X for Enhanced Integration.
A recombinant truncated FMDV 3AB protein used to better distinguish between infected and vaccinated cattle.
Evaluating the Pathogenic Potential of Environmental Escherichia coli by Using the Caenorhabditis elegans Infection Model.
Generation of a Sleeping Beauty Transposon-Based Cellular System for Rapid and Sensitive Screening for Compounds and Cellular Factors Limiting SARS-CoV-2 Replication.
Generation of PK-15 cell lines highly permissive to porcine circovirus 2 infection by transposon-mediated interferon-gamma gene transfer.
Hospital-acquired infections. Meet the bug buster.
IS711-based real-time PCR assay as a tool for detection of Brucella spp. in wild boars and comparison with bacterial isolation and serology.
Library Preparation for ATAC-Sequencing of Mouse CD4+ T Cells Isolated from the Lung and Lymph Nodes After Helminth Infection.
Molecular characterization of shrimp harbinger transposase derived 1 (HARBI1)-like and its role in white spot syndrome virus and Vibrio alginolyticus infection.
Protein-DNA assemblies controlling lytic development of bacteriophage Mu.
Q fever--selected issues.
Sequence analysis and quantification of transposase cDNAs of transposon TCp3.2 in Cydia pomonella larvae.
[Tetanus in Poland in 2006]
[Tetanus in Poland in 2007]
Infertility
Characterization of permissivity for hobo-mediated gonadal dysgenesis in Drosophila melanogaster.
IPB7 transposase behavior in Drosophila melanogaster and Aedes aegypti.
Somatic effects of P element activity in Drosophila melanogaster: pupal lethality.
Influenza, Human
Lack of evidence for pre-symptomatic transmission of pandemic influenza virus A(H1N1) 2009 in an outbreak among teenagers; Germany, 2009.
Ischemic Stroke
Biomechanics and hemodynamics of stent-retrievers.
Confirmatory Study of Time-Dependent Computed Tomographic Perfusion Thresholds for Use in Acute Ischemic Stroke.
Effect of atrial fibrillation on endovascular thrombectomy for acute ischemic stroke. A meta-analysis of individual patient data from six randomised trials: Results from the HERMES collaboration.
Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data.
The associations of plasma phospholipid arachidonic acid with cardiovascular diseases: A Mendelian randomization study.
Vampire bats yield potent clot buster for ischemic stroke.
Leukemia
Clinical significance of LEA-1 expression in adult acute myeloid leukemia.
Genome-wide mapping of binding sites of the transposase-derived SETMAR protein in the human genome.
Incipient intranuclear inclusion body disease in a 78-year-old woman.
Leukemia, B-Cell
Histone H1 quantity determines the efficiency of chromatin condensation in both apoptotic and live cells.
Leukemia, Myeloid, Acute
Clinical significance of LEA-1 expression in adult acute myeloid leukemia.
Lung Neoplasms
Should irinotecan or etoposide be used in combination with carboplatin for small cell lung cancer?
Lupus Erythematosus, Systemic
ATAC-seq on biobanked specimens defines a unique chromatin accessibility structure in naïve SLE B cells.
Lymphatic Metastasis
NONO Inhibits Lymphatic Metastasis of Bladder Cancer via Alternative Splicing of SETMAR.
Lymphoma
Gene expression profiling and chromatin immunoprecipitation identify DBN1, SETMAR and HIG2 as direct targets of SOX11 in mantle cell lymphoma.
Lymphoma, Mantle-Cell
Gene expression profiling and chromatin immunoprecipitation identify DBN1, SETMAR and HIG2 as direct targets of SOX11 in mantle cell lymphoma.
Malaria
An Anopheles stephensi Promoter-Trap: Augmenting Genome Annotation and Functional Genomics.
Development of the piggyBac transposable system for Plasmodium berghei and its application for random mutagenesis in malaria parasites.
nanos-Driven expression of piggyBac transposase induces mobilization of a synthetic autonomous transposon in the malaria vector mosquito, Anopheles stephensi.
Melanoma
Dysregulation of MITF Leads to Transformation in MC1R-Defective Melanocytes.
Methylation-mediated loss of SFRP2 enhances melanoma cell invasion via Wnt signaling.
PhiC31/PiggyBac modified stromal stem cells: effect of interferon ? and/or tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) on murine melanoma.
Transposase mapping identifies the genomic targets of BAP1 in uveal melanoma.
Metabolic Syndrome
Is metabolic syndrome associated to HIV infection per se? Results from the HERMES study.
Myocardial Infarction
A study of risk factors and complications in elderly hypertensive subjects.
Neoplasm Metastasis
NONO Inhibits Lymphatic Metastasis of Bladder Cancer via Alternative Splicing of SETMAR.
Neoplasms
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.
A DNA transposon-based approach to validate oncogenic mutations in the mouse.
A Transposon-based Analysis Reveals
ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice.
Application of Cu-64 NODAGA-PSMA PET in Prostate Cancer.
CD44 is a RAS/STAT5-regulated invasion receptor that triggers disease expansion in advanced mastocytosis.
Clinical Practice Observation of Trastuzumab in Patients with Human Epidermal Growth Receptor 2-Positive Metastatic Adenocarcinoma of the Stomach or Gastroesophageal Junction.
Control of Spontaneous HPV16 E6/E7 Expressing Oral Cancer in HLA-A2 (AAD) Transgenic Mice with Therapeutic HPV DNA Vaccine.
Dysregulation of MITF Leads to Transformation in MC1R-Defective Melanocytes.
Focal corticarl dysplasia in epilepsy is associated with GABA increase.
Immunotherapy of acute leukemia by chimeric antigen receptor-modified lymphocytes using an improved Sleeping Beauty transposon platform.
Individuality and variation of personal regulomes in primary human T cells.
Inhibition of NEDD8 and FAT10 ligase activities through the degrading enzyme NEDD8 ultimate buster 1: A potential anticancer approach.
Interventional bronchoscopy in the management of thoracic malignancy.
Metnase/SETMAR: a domesticated primate transposase that enhances DNA repair, replication, and decatenation.
Novel, genetically induced mouse model that recapitulates the histological morphology and immunosuppressive tumor microenvironment of metastatic peritoneal carcinomatosis.
PGBD5 promotes site-specific oncogenic mutations in human tumors.
piggyBac transposon/transposase system to generate CD19-specific T cells for the treatment of B-lineage malignancies.
SETMAR isoforms in glioblastoma: A matter of protein stability.
Sleeping Beauty transposon insertional mutagenesis based mouse models for cancer gene discovery.
Survival and proliferation of neural progenitor derived glioblastomas under hypoxic stress is controlled by a CXCL12/CXCR4 autocrine positive feedback mechanism.
The DNA Transposase PGBD5 Sensitizes Tumors to Inhibition of DNA Repair.
The Sleeping Beauty Transposon Vector System for Treatment of Rare Genetic Diseases: an Unrealized Hope?
Tracking and transforming neocortical progenitors by CRISPR/Cas9 gene targeting and PiggyBac transposase lineage labeling.
Transposase-driven rearrangements in human tumors.
Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality.
Osteoarthritis
Chromatin accessibility landscapes of immune cells in rheumatoid arthritis nominate monocytes in disease pathogenesis.
Osteosarcoma
Sustained high level transgene expression in mammalian cells mediated by the optimized piggyBac transposon system.
Otitis Media
Epidemiology of Otitis Media with Spontaneous Perforation of the Tympanic Membrane in Young Children and Association with Bacterial Nasopharyngeal Carriage, Recurrences and Pneumococcal Vaccination in Catalonia, Spain - The Prospective HERMES Study.
Paratuberculosis
IS900 targets translation initiation signals in Mycobacterium avium subsp. paratuberculosis to facilitate expression of its hed gene.
p43, the protein product of the atypical insertion sequence IS900, is expressed in Mycobacterium paratuberculosis.
Paratuberculosis.
Peripheral Arterial Disease
The associations of plasma phospholipid arachidonic acid with cardiovascular diseases: A Mendelian randomization study.
Peritoneal Neoplasms
Novel, genetically induced mouse model that recapitulates the histological morphology and immunosuppressive tumor microenvironment of metastatic peritoneal carcinomatosis.
Pneumonia
Coxiella burnetii, the agent of Q fever in Brazil: its hidden role in seronegative arthritis and the importance of molecular diagnosis based on the repetitive element IS1111 associated with the transposase gene.
Q Fever
Coxiella burnetii, the agent of Q fever in Brazil: its hidden role in seronegative arthritis and the importance of molecular diagnosis based on the repetitive element IS1111 associated with the transposase gene.
Diagnostic usefulness of molecular detection of Coxiella burnetii from blood of patients with suspected acute Q fever.
Respiratory Tract Infections
Introducing a new HERMES project on respiratory infections.
Retinal Degeneration
The Sleeping Beauty Transposon Vector System for Treatment of Rare Genetic Diseases: an Unrealized Hope?
Retinoblastoma
Structure-function analysis of the THAP zinc finger of THAP1, a large C2CH DNA-binding module linked to Rb/E2F pathways.
Rhabdoid Tumor
PGBD5 promotes site-specific oncogenic mutations in human tumors.
Rhinitis
A randomized, double-blind, parallel trial comparing capsaicin nasal spray with placebo in subjects with a significant component of nonallergic rhinitis.
Sarcoma, Avian
Neuronal Precursor-Restricted Transduction via in Utero CNS Gene Delivery of a Novel Bipartite HSV Amplicon/Transposase Hybrid Vector.
Retroviral integrases and their cousins.
The three-dimensional structure of a Tn5 transposase-related protein determined to 2.9-A resolution.
Scabies
nec1, a gene conferring a necrogenic phenotype, is conserved in plant-pathogenic Streptomyces spp. and linked to a transposase pseudogene.
Phylogenetic Analysis of 16S rRNA Genes and PCR Analysis of the nec1 Gene from Streptomyces spp. Causing Common Scab, Pitted Scab, and Netted Scab in Finland.
Phylogenetic analysis of 16S rRNA genes and PCR analysis of the nec1 gene from Streptomyces spp. causing common scab, pitted scab, and netted scab in Finland.
Small Cell Lung Carcinoma
Should irinotecan or etoposide be used in combination with carboplatin for small cell lung cancer?
Starvation
Starvation-induced Mucts62-mediated coding sequence fusion: a role for ClpXP, Lon, RpoS and Crp.
Transcriptomes of Frankia sp. strain CcI3 in growth transitions.
Stomach Neoplasms
Clinical Practice Observation of Trastuzumab in Patients with Human Epidermal Growth Receptor 2-Positive Metastatic Adenocarcinoma of the Stomach or Gastroesophageal Junction.
Stroke
#Fake news: a systematic review of mechanical thrombectomy results among neurointerventional stroke surgeons on Twitter.
A study of risk factors and complications in elderly hypertensive subjects.
Brain endothelial cell specific integrins and ischemic stroke.
Computed Tomography Perfusion-Based Machine Learning Model Better Predicts Follow-Up Infarction in Patients With Acute Ischemic Stroke.
Confirmatory Study of Time-Dependent Computed Tomographic Perfusion Thresholds for Use in Acute Ischemic Stroke.
Effect of age and baseline ASPECTS on outcomes in large-vessel occlusion stroke: results from the HERMES collaboration.
Endovascular Treatment Effect Diminishes With Increasing Thrombus Perviousness: Pooled Data From 7 Trials on Acute Ischemic Stroke.
HERMES: messenger for stroke interventional treatment.
Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data.
Mechanical thrombectomy performs similarly in real world practice: a 2016 nationwide study from the Czech Republic.
Rapid Alteplase Administration Improves Functional Outcomes in Patients With Stroke due to Large Vessel Occlusions.
Stroke Laterality Did Not Modify Outcomes in the HERMES Meta-Analysis of Individual Patient Data of 7 Trials.
Volumetric and Spatial Accuracy of Computed Tomography Perfusion Estimated Ischemic Core Volume in Patients With Acute Ischemic Stroke.
Tauopathies
Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration.
Tetanus
The potential effects of introducing microneedle patch vaccines into routine vaccine supply chains.
Thalassemia
In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia.
Thrombosis
Brain endothelial cell specific integrins and ischemic stroke.
Thrombectomy for acute internal carotid thrombosis: five thrombectomy devices compared.
Tuberculosis
Comprehensive study of instable regions in Pseudomonas aeruginosa and Mycobacterium tuberculosis.
Description and characterization of IS994, a putative IS3 family insertion sequence from the salmon pathogen, Renibacterium salmoninarum.
Identification and sequence analysis of IS6501, an insertion sequence in Brucella spp.: relationship between genomic structure and the number of IS6501 copies.
Tyrosinemias
Messenger RNA as a Source of Transposase for Sleeping Beauty Transposon-mediated Correction of Hereditary Tyrosinemia Type I.
Urinary Bladder Neoplasms
NONO Inhibits Lymphatic Metastasis of Bladder Cancer via Alternative Splicing of SETMAR.
Urolithiasis
[The recommendations of the S2k guideline for the diagnosis, therapy and metaphylaxis of urolithiasis provide a safe course of action for ureterorenoscopic stone treatment - results of the BUSTER study].
Vasospasm, Intracranial
Semiquantitative software SPECT analysis in aneurysmal subarachnoid hemorrhage-related vasospasm.
Virus Diseases
Early modification of host cell gene expression induced by HIV-1.
Whooping Cough
[Functional activity of transposase of Bordetella pertussis IS element in Escherichia coli cells]
[Identification of the open reading frame coding transposase of Bordetella pertussis RS-element]
[Pertussis in Poland in 1999]
Wilms Tumor
Comparison of lentiviral and sleeping beauty mediated ?? T cell receptor gene transfer.
Yellow Fever
Green fluorescent protein as a genetic marker in transgenic Aedes aegypti.
Purified mariner (Mos1) transposase catalyzes the integration of marked elements into the germ-line of the yellow fever mosquito, Aedes aegypti.
Stable transformation of the yellow fever mosquito, Aedes aegypti, with the Hermes element from the housefly.
Structure of hermes integrations in the germline of the yellow fever mosquito, Aedes aegypti.
Zoonoses
Ehrlichia Isolate from a Minnesota Tick: Characterization and Genetic Transformation.
Novel IS711 chromosomal location useful for identification of marine mammal Brucella genotype ST27, which is associated with zoonotic infection.