Reference on EC 2.7.7.60 - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cane, D.E.; Chow, C.; Lillo, A.; Kang, I.
Molecular cloning, expression and characterization of the first three genes in the mevalonate-independent isoprenoid pathway in Streptomyces coelicolor
Bioorg. Med. Chem.
9
1467-1477
2001
Escherichia coli, Streptomyces coelicolor, Streptomyces coelicolor CH999
Richard, S.B.; Bowman, M.E.; Kwiatkowski, W.; Kang, L.; Chow, C.; Lillo, A.M.; Cane, D.E.; Noel, J.P.
Structure of 4-diphosphocytidyl-2-C-methylerythritol synthetase involved in mevalonate-independent isoprenoid biosynthesis
Nature Struct. Biol.
8
641-648
2001
Escherichia coli, Mycobacterium tuberculosis, Plasmodium falciparum
Kemp, L.E.; Bond, C.S.; Hunter, W.N.
Crystallization and preliminary x-ray diffraction studies of recombinant Escherichia coli 4-diphosphocytidyl-2-C-methyl-D-erythritol synthetase
Acta Crystallogr. Sect. D
57
1189-1191
2001
Escherichia coli
Rohdich, F.; Wungsintaweekul, J.; Eisenreich, W.; Richter, G.; Schuhr, C.A.; Hecht, S.; Zenk, M.H.; Bacher, A.
Biosynthesis of terpenoids: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase of Arabidopsis thaliana
Proc. Natl. Acad. Sci. USA
97
6451-6456
2000
Arabidopsis thaliana, Escherichia coli (Q46893), Escherichia coli
Kuzuyama, T.; Takagi, M.; Kaneda, K.; Dairi, T.; Seto, H.
Formation of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol from 2-C-methyl-D-erythritol 4-phosphate by 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, a new enzyme in the nonmevalonate pathway
Tetrahedron Lett.
41
703-706
2000
Escherichia coli
-
Rohdich, F.; Wungsintaweekul, J.; Fellermeier, M.; Sagner, S.; Herz, S.; Kis, K.; Eisenreich, W.; Bacher, A.; Zenk, M.H.
Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol
Proc. Natl. Acad. Sci. USA
96
11758-11763
1999
Arabidopsis thaliana, Escherichia coli, Escherichia coli DH5-alpha
Gabrielsen, M.; Bond, C.S.; Hallyburton, I.; Hecht, S.; Bacher, A.; Eisenreich, W.; Rohdich, F.; Hunter, W.N.
Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis
J. Biol. Chem.
279
52753-52761
2004
Agrobacterium tumefaciens, Campylobacter jejuni, Escherichia coli (Q46893), Escherichia coli
Kemp, L.E.; Bond, C.S.; Hunter, W.N.
Structure of a tetragonal crystal form of Escherichia coli 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Acta Crystallogr. Sect. D
59
607-610
2003
Escherichia coli
Bernal, C.; Palacin, C.; Boronat, A.; Imperial, S.
A colorimetric assay for the determination of 4-diphosphocytidyl-2-C-methyl-D-erythritol 4-phosphate synthase activity
Anal. Biochem.
337
55-61
2005
Escherichia coli
Richard, S.B.; Lillo, A.M.; Tetzlaff, C.N.; Bowman, M.E.; Noel, J.P.; Cane, D.E.
Kinetic analysis of Escherichia coli 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase, wild type and mutants, reveals roles of active site amino acids
Biochemistry
43
12189-12197
2004
Escherichia coli (Q46893), Escherichia coli
Zhao, X.; Miller, J.R.; Jiang, Y.; Marletta, M.A.; Cronan, J.E.
Assembly of the covalent linkage between lipoic acid and its cognate enzymes
Chem. Biol.
10
1293-1302
2003
Escherichia coli
Lherbet, C.; Pojer, F.; Richard, S.B.; Noel, J.P.; Poulter, C.D.
Absence of substrate channeling between active sites in the Agrobacterium tumefaciens IspDF and IspE enzymes of the methyl erythritol phosphate pathway
Biochemistry
45
3548-3553
2006
Agrobacterium tumefaciens
Gabrielsen, M.; Kaiser, J.; Rohdich, F.; Eisenreich, W.; Laupitz, R.; Bacher, A.; Bond, C.S.; Hunter, W.N.
The crystal structure of a plant 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate
FEBS J.
273
1065-1073
2006
Arabidopsis thaliana (P69834), Arabidopsis thaliana
Illarionova, V.; Kaiser, J.; Ostrozhenkova, E.; Bacher, A.; Fischer, M.; Eisenreich, W.; Rohdich, F.
Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods
J. Org. Chem.
71
8824-8834
2006
Escherichia coli
Kim, S.M.; Kuzuyama, T.; Chang, Y.J.; Kwon, H.J.; Kim, S.U.
Cloning and functional characterization of 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (GbMECT) gene from Ginkgo biloba
Phytochemistry
67
1435-1441
2006
Ginkgo biloba (Q0R5D7), Ginkgo biloba
Sando, T.; Takeno, S.; Watanabe, N.; Okumoto, H.; Kuzuyama, T.; Yamashita, A.; Hattori, M.; Ogasawara, N.; Fukusaki, E.; Kobayashi, A.
Cloning and characterization of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway genes of a natural-rubber producing plant, Hevea brasiliensis
Biosci. Biotechnol. Biochem.
72
2903-2917
2008
Hevea brasiliensis (A9ZN09), Hevea brasiliensis (A9ZN10), Hevea brasiliensis
Shi, W.; Feng, J.; Zhang, M.; Lai, X.; Xu, S.; Zhang, X.; Wang, H.
Biosynthesis of isoprenoids: characterization of a functionally active recombinant 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD) from Mycobacterium tuberculosis H37Rv
J. Biochem. Mol. Biol.
40
911-920
2007
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Obiol-Pardo, C.; Cordero, A.; Rubio-Martinez, J.; Imperial, S.
Homology modeling of Mycobacterium tuberculosis 2C-methyl-D-erythritol-4-phosphate cytidylyltransferase, the third enzyme in the MEP pathway for isoprenoid biosynthesis
J. Mol. Model.
16
1061-1073
2010
Mycobacterium tuberculosis (P9WKG9), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WKG9)
Tsang, A.; Seidle, H.; Jawaid, S.; Zhou, W.; Smith, C.; Couch, R.
Francisella tularensis 2-C-Methyl-D-Erythritol 4-phosphate Cytidylyltransferase: Kinetic characterization and phosphoregulation
PLoS ONE
6
e20884
2011
Francisella tularensis, Francisella tularensis FSC155
Brault, J.P.; Friesen, J.A.
Characterization of cytidylyltransferase enzyme activity through high performance liquid chromatography
Anal. Biochem.
510
26-32
2016
Listeria monocytogenes
Imlay, L.; Armstrong, C.; Masters, M.; Li, T.; Price, K.; Edwards, R.; Mann, K.; Li, L.; Stallings, C.; Berry, N.; O'Neill, P.; Odom, A.
Plasmodium IspD (2-C-methyl-D-erythritol 4-phosphate cytidyltransferase), an essential and druggable antimalarial target
ACS Infect. Dis.
1
157-167
2016
Plasmodium vivax (A5K9U5), Mycobacterium tuberculosis (P9WKG9), Plasmodium falciparum (Q8I273), Plasmodium falciparum, Plasmodium vivax Salvador I (A5K9U5), Mycobacterium tuberculosis H37Rv (P9WKG9), Mycobacterium tuberculosis ATCC 25618 (P9WKG9)
Ghavami, M.; Merino, E.F.; Yao, Z.K.; Elahi, R.; Simpson, M.E.; Fernandez-Murga, M.L.; Butler, J.H.; Casasanta, M.A.; Krai, P.M.; Totrov, M.M.; Slade, D.J.; Carlier, P.R.; Cassera, M.B.
Biological studies and target engagement of the 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD)-targeting antimalarial agent (1 R,3 S)-MMV008138 and analogs
ACS Infect. Dis.
4
549-559
2018
Plasmodium falciparum (Q8I273)
Haymond, A.; Dowdy, T.; Johny, C.; Johnson, C.; Ball, H.; Dailey, A.; Schweibenz, B.; Villarroel, K.; Young, R.; Mantooth, C.J.; Patel, T.; Bases, J.; Dowd, C.S.; Couch, R.D.
A high-throughput screening campaign to identify inhibitors of DXP reductoisomerase (IspC) and MEP cytidylyltransferase (IspD)
Anal. Biochem.
542
63-75
2018
Francisella tularensis subsp. novicida (A0Q5K1), Escherichia coli (Q46893), Francisella tularensis subsp. novicida Utah 112 (A0Q5K1)
Saggu, G.S.; Garg, S.; Pala, Z.R.; Kochar, S.K.; Saxena, V.
Deciphering the role of IspD (2-C-methyl-D-erythritol 4-phosphate cytidyltransferase) enzyme as a potential therapeutic drug target against Plasmodium vivax
Gene
675
240-253
2018
Plasmodium vivax (A5K9U5), Plasmodium vivax, Plasmodium vivax Salvador I (A5K9U5)
Kumar, P.; Kumar, M.; Kumar, H.; Rana, S.; Kumar, J.; Sahoo, G.
In silico targeting methylerythritol phosphate pathway IspD enzyme of Mycobacterium tuberculosis for novel anti-mycobacterial drug discovery
J. Appl. Pharm. Sci.
10
23-29
2020
Mycobacterium tuberculosis (P9WKG9), Mycobacterium tuberculosis H37Rv (P9WKG9), Mycobacterium tuberculosis ATCC 25618 (P9WKG9)
-
Chellapandi, P.; Prathiviraj, R.; Prisilla, A.
Deciphering structure, function and mechanism of Plasmodium IspD homologs from their evolutionary imprints
J. Comput. Aided Mol. Des.
33
419-436
2019
Plasmodium falciparum (A0A024WEN0), Plasmodium falciparum Tanzania (20000708) (A0A024WEN0)
Jin, Y.; Liu, Z.; Li, Y.; Liu, W.; Tao, Y.; Wang, G.
A structural and functional study on the 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase (IspD) from Bacillus subtilis
Sci. Rep.
6
36379
2016
Bacillus subtilis (Q06755), Bacillus subtilis, Escherichia coli (Q46893), Escherichia coli, Bacillus subtilis 168 (Q06755), Bacillus subtilis DSM 23778 (Q06755)
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