Information on EC 2.7.7.51 - adenylylsulfate-ammonia adenylyltransferase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
2.7.7.51
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RECOMMENDED NAME
GeneOntology No.
adenylylsulfate-ammonia adenylyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
adenylyl sulfate + NH3 = adenosine 5'-phosphoramidate + sulfate
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
adenosine 5'-phosphoramidate biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
adenylyl-sulfate:ammonia adenylyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
79121-94-1
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
cf. EC 3.6.1.29
UniProt
Manually annotated by BRENDA team
Microorganisms
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
adenosine 5'-phosphorofluoridate + NH3
adenosine 5'-phosphoramidate + F-
show the reaction diagram
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-
-
?
adenosine 5'-phosphosulfate + NH3
adenosine 5'-phosphoramidate + SO42­- + H+
show the reaction diagram
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-
-
?
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
show the reaction diagram
ApppA + NH3
adenosine 5'-phosphoramidate + ppA
show the reaction diagram
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-
-
?
cytosine 5'-phosphosulfate + NH3
cytosine 5'-phosphoramidate + SO42­- + H+
show the reaction diagram
91% of the rate with adenosine 5'-phosphosulfate
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-
?
guanosine 5'-phosphosulfate + NH3
guanosine 5'-phosphoramidate + SO42­- + H+
show the reaction diagram
47% of the rate with adenosine 5'-phosphosulfate
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-
?
uridine 5'-phosphosulfate + NH3
uridine 5'-phosphoramidate + SO42­- + H+
show the reaction diagram
56% of the rate with adenosine 5'-phosphosulfate
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-
?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
adenylylsulfate + NH3
adenosine 5'-phosphoramidate + sulfate
show the reaction diagram
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.6
adenosine 5'-phosphorofluoridate
pH 10.6, 30°C
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2.4
adenosine 5'-phosphosulfate
pH 10.6, 30°C
0.82
adenylylsulfate
10
ammonia
60
NH3
cosubstrate adenosine 5'-phosphorofluoridate, pH 10.6, 30°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
60000 - 65000
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
trimer
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE