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Disease on EC 2.7.7.48 - RNA-directed RNA polymerase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
Proteomic analysis on the alteration of protein expression in the placental villous tissue of early pregnancy loss.
Acquired Immunodeficiency Syndrome
1H, 13C, and 15N backbone chemical shift assignments of coronavirus-2 non-structural protein Nsp10.
Crystal structure of the RNA-dependent RNA polymerase from influenza C virus.
Expression of human immunodeficiency virus type 1 (HIV-1) gag, pol, and env proteins from chimeric HIV-1-poliovirus minireplicons.
Finding, Conducting, and Nurturing Science: A Virologist's Memoir.
Identification of SARS-CoV-2 inhibitors from extracts of Houttuynia cordata Thunb.
Improvement of sensitivity and selectivity of high-performance liquid chromatography for anti-retroviral drugs (non-reverse transcriptase inhibitors) by diamond-electrode electrochemical and fluorescence detection.
Interactions and Localization of Escherichia coli Error-Prone DNA Polymerase IV after DNA Damage.
Introduction and immunopathogenesis of acquired immune deficiency syndrome.
Involvement of protein acetylation in glucose-induced transcription of a stress-responsive promoter.
Longitudinal analysis of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte responses: a predominant gag-specific response is associated with nonprogressive infection.
Modifications of chromatin structure in control of gene expression.
Nus transcription elongation factors and RNase III modulate small ribosome subunit biogenesis in Escherichia coli.
On the early emergence of reverse transcription: theoretical basis and experimental evidence.
On the Statistical Accuracy of Biomarker Assays for HIV Incidence.
Phage-displayed La/SS-B antigen as a diagnostic reagent.
Prevalence and Virologic Consequences of Transmitted HIV-1 Drug Resistance in Uganda.
Problems posed by natural environments for monitoring microorganisms.
RNA Polymerase Clamp Movement Aids Dissociation from DNA but Is Not Required for RNA Release at Intrinsic Terminators.
Structural mechanisms of HIV drug resistance.
Suramin inhibits tumor cell cytotoxicity mediated through natural killer cells, lymphokine-activated killer cells, monocytes, and tumor necrosis factor.
Synthetic peptides for AIDS research.
The Current Recommended Drugs and Strategies for the Treatment of Coronavirus Disease (COVID-19).
When machines get stuck--obstructed RNA polymerase II: displacement, degradation or suicide.
[Therapeutic potential of Ro 5-3335. New active benzodiazepine in vitro against HIV-1 viruses resistant or non-resistant to AZT]
Acromegaly
The clinical response to somatostatin analogues in acromegaly correlates to the somatostatin receptor subtype 2a protein expression of the adenoma.
Acute Kidney Injury
Renal failure due to scleroderma with thrombotic microangiopathy developing in a woman treated with carboplatin for ovarian cancer.
Acute Lung Injury
Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress.
Emodin Alleviates Severe Acute Pancreatitis-Associated Acute Lung Injury by Inhibiting the Cold-Inducible RNA-Binding Protein (CIRP)-Mediated Activation of the NLRP3/IL-1?/CXCL1 Signaling.
Extracellular CIRP Induces Inflammation in Alveolar Type II Cells via TREM-1.
Inhibition of a triggering receptor expressed on myeloid cells-1 (TREM-1) with an extracellular cold-inducible RNA-binding protein (eCIRP)-derived peptide protects mice from intestinal ischemia-reperfusion injury.
Lung transcriptome of a COVID-19 patient and systems biology predictions suggest impaired surfactant production which may be druggable by surfactant therapy.
Nonstructural Protein 1 (NS1)-Mediated Inhibition of c-Abl Results in Acute Lung Injury and Priming for Bacterial Coninfections: Insights Into 1918 H1N1 Pandemic?
Adenocarcinoma
Diffuse expression of RNA-binding protein IMP3 predicts high-stage lymph node metastasis and poor prognosis in colorectal adenocarcinoma.
Expression of RNA-binding protein LIN28 in classic gastric hepatoid carcinomas, gastric fetal type gastrointestinal adenocarcinomas, and hepatocellular carcinomas: An immunohistochemical study with comparison to SALL4, alpha-fetoprotein, glypican-3, and Hep Par1.
Radiation Sensitivity of Esophageal Adenocarcinoma: The Contribution of the RNA-Binding Protein RNPC1 and p21-Mediated Cell Cycle Arrest to Radioresistance.
The RNA-binding protein MEX3A is a prognostic factor and regulator of resistance to gemcitabine in pancreatic ductal adenocarcinoma.
Adenocarcinoma of Lung
A gene mutation in RNA-binding protein 10 is associated with lung adenocarcinoma progression and poor prognosis.
Development and validation of a prediction model for lung adenocarcinoma based on RNA-binding protein.
Expression of the RNA-binding protein HuR and its clinical significance in human stage I and II lung adenocarcinoma.
Expression profile, clinical significance, and biological function of insulin-like growth factor 2 messenger RNA-binding proteins in non-small cell lung cancer.
Hu/elav RNA-binding protein HuR regulates parathyroid hormone related peptide expression in human lung adenocarcinoma cells.
Novel mechanisms for osteogenic differentiation of human aortic valve interstitial cells.
Predicting the Clinical Outcome of Lung Adenocarcinoma Using a Novel Gene Pair Signature Related to RNA-Binding Protein.
The role of RBM10 mutations in the development, treatment, and prognosis of lung adenocarcinoma.
[Tristetraprolin inhibits autophagy in cultured lung cancer cells via the nuclear factor-?B pathway].
Adenoma
The clinical response to somatostatin analogues in acromegaly correlates to the somatostatin receptor subtype 2a protein expression of the adenoma.
Adrenocortical Carcinoma
Characterization of atrial-natriuretic-factor-receptor-coupled membrane guanylate cyclase from rat and mouse testes.
Long noncoding RNA ASB16-AS1 inhibits adrenocortical carcinoma cell growth by promoting ubiquitination of RNA-binding protein HuR.
African Horse Sickness
A comparison of the nucleotide sequences of cognate NS2 genes of three different orbiviruses.
Characterization of a nonstructural phosphoprotein of two orbiviruses.
Characterization of tubular structures composed of nonstructural protein NS1 of African horsesickness virus expressed in insect cells.
Identification of African horse sickness virus in cell culture using a digoxigenin-labeled RNA probe.
Sequence analysis of the RNA polymerase gene of African horse sickness virus.
The effect of temperature on the in vitro transcriptase reaction of bluetongue virus, epizootic haemorrhagic disease virus and African horsesickness virus.
African Swine Fever
African swine fever virus encodes two genes which share significant homology with the two largest subunits of DNA-dependent RNA polymerases.
African Swine Fever Virus pB119L Protein Is a Flavin Adenine Dinucleotide-Linked Sulfhydryl Oxidase.
An African swine fever virus gene with a similarity to eukaryotic RNA polymerase subunit 6.
The African swine fever virus nonstructural protein pB602L is required for formation of the icosahedral capsid of the virus particle.
Aleutian Mink Disease
Caspase cleavage of the nonstructural protein NS1 mediates replication of Aleutian mink disease parvovirus.
Purification and characterization of the major nonstructural protein (NS-1) of Aleutian mink disease parvovirus.
The abundant R2 mRNA generated by aleutian mink disease parvovirus is tricistronic, encoding NS2, VP1, and VP2.
Alopecia Areata
Clinical Relevance for Serum Cold-Inducible RNA-Binding Protein Level in Alopecia Areata.
Alphavirus Infections
Dephosphorylation of HuR Protein During Alphavirus Infection Is Associated with HuR Relocalization to the Cytoplasm.
Innovative cancer vaccine strategies based on the identification of tumour-associated antigens.
Alzheimer Disease
A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons.
A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.
An optimized InCell Western screening technique identifies hexachlorophene as a novel potent TDP43 targeting drug.
Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease.
Biomolecular condensation of the microtubule-associated protein tau.
Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein.
Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease.
Lack of association between TDP-43 pathology and tau mis-splicing in Alzheimer's disease.
Low-complexity domain of U1-70K modulates phase separation and aggregation through distinctive basic-acidic motifs.
Myo-granules Connect Physiology and Pathophysiology.
Preferential Binding of a stable G3BP Ribonucleoprotein Complex to Intron-retaining Transcripts in Mouse Brain and Modulation of their Expression in the Cerebellum.
PRO-MINE: A Bioinformatics Repository and Analytical Tool for TARDBP Mutations.
Amyloidosis
AFM study of Escherichia coli RNA polymerase ?(70) subunit aggregation.
Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease.
Amyotrophic Lateral Sclerosis
3'UTR Length-Dependent Control of SynGAP Isoform ?2 mRNA by FUS and ELAV-like Proteins Promotes Dendritic Spine Maturation and Cognitive Function.
A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons.
A matter of balance.
A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.
Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.
Abnormal RNA stability in amyotrophic lateral sclerosis.
Activity-dependent FUS dysregulation disrupts synaptic homeostasis.
ALS mutant FUS proteins are recruited into stress granules in induced pluripotent stem cell-derived motoneurons.
ALS Mutations Disrupt Phase Separation Mediated by ?-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain.
ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair.
ALS-Linked Mutations Enlarge TDP-43-Enriched Neuronal RNA Granules in the Dendritic Arbor.
ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity.
ALS/FTLD-Linked Mutations in FUS Glycine Residues Cause Accelerated Gelation and Reduced Interactions with Wild-Type FUS.
Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons.
An ALS-associated mutation in the FUS 3'-UTR disrupts a microRNA-FUS regulatory circuitry.
An Amyloid-Like Pathological Conformation of TDP-43 Is Stabilized by Hypercooperative Hydrogen Bonds.
An optimized InCell Western screening technique identifies hexachlorophene as a novel potent TDP43 targeting drug.
Ataxin-2: From RNA Control to Human Health and Disease.
Autosomal dominant inheritance of rapidly progressive amyotrophic lateral sclerosis due to a truncation mutation in the fused in sarcoma (FUS) gene.
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein.
Characteristic Features of FUS Inclusions in Spinal Motor Neurons of Sporadic Amyotrophic Lateral Sclerosis.
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.
Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects.
Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1.
DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation.
Detection of TAR DNA-binding protein 43 (TDP-43) oligomers as initial intermediate species during aggregate formation.
Development of a mouse monoclonal antibody for the detection of asymmetric dimethylarginine of Translocated in LipoSarcoma/FUsed in Sarcoma and its application in analyzing methylated TLS.
Differential toxicity of TAR DNA-binding protein 43 isoforms depends on their submitochondrial localization in neuronal cells.
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.
Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS.
Exploring the Interaction of
Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.
Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching.
Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation.
Functional characterization of a FUS mutant zebrafish line as a novel genetic model for ALS.
FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons.
FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention.
FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2.
FUS contributes to mTOR-dependent inhibition of translation.
FUS is sequestered in nuclear aggregates in ALS patient fibroblasts.
FUS Regulates Activity of MicroRNA-Mediated Gene Silencing.
FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved introns.
FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis.
Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis.
HDAC6 is a Bruchpilot deacetylase that facilitates neurotransmitter release.
High-content RNAi screening identifies the Type 1 inositol triphosphate receptor as a modifier of TDP-43 localization and neurotoxicity.
Hu antigen R (HuR) is a positive regulator of the RNA-binding proteins TDP-43 and FUS/TLS: implications for amyotrophic lateral sclerosis.
Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function.
Identification of Genetic Modifiers of TDP-43 Neurotoxicity in Drosophila.
Inter-Species Differences in Regulation of the Progranulin-Sortilin Axis in TDP-43 Cell Models of Neurodegeneration.
Intrinsic disorder in proteins involved in amyotrophic lateral sclerosis.
Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two Distinct Types of ALS/FTD-Linked FUS Mutations.
Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function.
Low Level of Expression of C-Terminally Truncated Human FUS Causes Extensive Changes in the Spinal Cord Transcriptome of Asymptomatic Transgenic Mice.
Mechanisms of TDP-43 Proteinopathy Onset and Propagation.
Mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex.
Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity.
Molecular structure and interactions within amyloid-like fibrils formed by a low-complexity protein sequence from FUS.
Motor neuron expression of the voltage-gated calcium channel cacophony restores locomotion defects in a Drosophila, TDP-43 loss of function model of ALS.
Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules.
Myo-granules Connect Physiology and Pathophysiology.
N-terminal acetylation modestly enhances phase separation and reduces aggregation of the low-complexity domain of RNA-binding protein fused in sarcoma.
Neuron-to-Neuron Transfer of FUS in Drosophila Primary Neuronal Culture Is Enhanced by ALS-Associated Mutations.
Neurotoxic effects of TDP-43 overexpression in C. elegans.
Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS.
PRO-MINE: A Bioinformatics Repository and Analytical Tool for TARDBP Mutations.
Proteomic Analysis of Dynein-Interacting Proteins in Amyotrophic Lateral Sclerosis Synaptosomes Reveals Alterations in the RNA-Binding Protein Staufen1.
Quantitative analysis of cryptic splicing associated with TDP-43 depletion.
Restoration of motor defects caused by loss of Drosophila TDP-43 by expression of the voltage-gated calcium channel, Cacophony, in central neurons.
RNA-binding proteins in neurodegenerative disease: TDP-43 and beyond.
S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD.
Severe respiratory changes at end stage in a FUS-induced disease state in adult rats.
Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS.
Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction.
Specific aromatic foldamers potently inhibit spontaneous and seeded A?42 and A?43 fibril assembly.
Split GFP technologies to structurally characterize and quantify functional biomolecular interactions of FTD-related proteins.
Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation.
Structural basis for RNA recognition by the N-terminal tandem RRM domains of human RBM45.
SUMOylation Regulates TDP-43 Splicing Activity and Nucleocytoplasmic Distribution.
Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS.
TBPH/TDP-43 modulates translation of Drosophila futsch mRNA through an UG-rich sequence within its 5'UTR.
TDP-43 ?-helical structure tunes liquid-liquid phase separation and function.
TDP-43 accelerates deadenylation of target mRNAs by recruiting Caf1 deadenylase.
TDP-43 and NOVA-1 RNA-binding proteins as competitive splicing regulators of the schizophrenia-associated TNIK gene.
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.
TDP-43 controls lysosomal pathways thereby determining its own clearance and cytotoxicity.
TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway.
TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity.
TDP-43 proteinopathy in Theiler's murine encephalomyelitis virus infection.
TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets.
TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1.
TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration.
TDP-43, an ALS Linked Protein, Regulates Fat Deposition and Glucose Homeostasis.
The FTD/ALS-associated RNA-binding protein TDP-43 regulates the robustness of neuronal specification through microRNA-9a in Drosophila.
The Impact of ALS-Associated Genes hnRNPA1, MATR3, VCP and UBQLN2 on the Severity of TDP-43 Aggregation.
The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients.
The role of FUS gene variants in neurodegenerative diseases.
Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.
Translocated in liposarcoma regulates the distribution and function of mammalian enabled, a modulator of actin dynamics.
Transposable Elements in TDP-43-Mediated Neurodegenerative Disorders.
Viral Infections Exacerbate FUS-ALS Phenotypes in iPSC-Derived Spinal Neurons in a Virus Species-Specific Manner.
Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation.
Anemia
A truncated apoptin protein variant selectively kills cancer cells.
Haemolytic anaemia precipitated by dengue fever.
Identification of a novel cell-penetrating peptide derived from the capsid protein of chicken anemia virus and its application in gene delivery.
Improving the potency of DNA vaccine against Chicken Anemia Virus (CAV) by fusing VP1 protein of CAV to Marek's Disease Virus (MDV) Type-1 VP22 protein.
Infectious salmon anemia virus (ISAV) genomic segment 3 encodes the viral nucleoprotein (NP), an RNA-binding protein with two monopartite nuclear localization signals (NLS).
Lactobacillus acidophilus as a live vehicle for oral immunization against chicken anemia virus.
Silver nanoparticles induced RNA polymerase-silver binding and RNA transcription inhibition in erythroid progenitor cells.
Simultaneous expression of recombinant baculovirus-encoded chicken anaemia virus (CAV) proteins VP1 and VP2 is required for formation of the CAV-specific neutralizing epitope.
Anemia, Hemolytic
Effect of phenylhydrazine-induced hemolytic anemia on nuclear RNA polymerase activity of the mouse spleen.
Anemia, Hypochromic
A new method for functional analysis of plastid EMBRYO-DEFECTIVE PPR genes by efficiently constructing cosuppression lines in Arabidopsis.
Aneurysm
Detection of active cytomegalovirus infection in inflammatory aortic aneurysms with RNA polymerase chain reaction.
Anodontia
Endocrine Aspects of 4H Leukodystrophy: A Case Report and Review of the Literature.
Anthrax
Bacillus anthracis Virulence Regulator AtxA Binds Specifically to the pagA Promoter Region.
Antiphospholipid Syndrome
Scleroderma-specific autoantibodies embedded in immune complexes mediate endothelial damage: an early event in the pathogenesis of systemic sclerosis.
Aortic Aneurysm
Detection of active cytomegalovirus infection in inflammatory aortic aneurysms with RNA polymerase chain reaction.
Regarding "Detection of active cytomegalovirus infection in inflammatory aortic aneurysms with RNA polymerase chain reaction".
Aortic Aneurysm, Abdominal
Cold-inducible RNA-binding protein plays a central role in the pathogenesis of abdominal aortic aneurysm in a murine experimental model.
Aortic Valve Stenosis
Novel mechanisms for osteogenic differentiation of human aortic valve interstitial cells.
Apraxias
Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.
Arbovirus Infections
Arboviruses and the Challenge to Establish Systemic and Persistent Infections in Competent Mosquito Vectors: The Interaction With the RNAi Mechanism.
Arteritis
A zinc finger-containing papain-like protease couples subgenomic mRNA synthesis to genome translation in a positive-stranded RNA virus.
Adaptive Mutations in Replicase Transmembrane Subunits Can Counteract Inhibition of Equine Arteritis Virus RNA Synthesis by Cyclophilin Inhibitors.
Alternative proteolytic processing of the arterivirus replicase ORF1a polyprotein: evidence that NSP2 acts as a cofactor for the NSP4 serine protease.
Arterivirus nsp12 versus the coronavirus nsp16 2'-O-methyltransferase: comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteins.
Biochemical characterization of the equine arteritis virus helicase suggests a close functional relationship between arterivirus and coronavirus helicases.
Equine arteritis virus does not induce interferon production in equine endothelial cells: identification of nonstructural protein 1 as a main interferon antagonist.
Functional properties of the predicted helicase of porcine reproductive and respiratory syndrome virus.
Lelystad virus, the causative agent of porcine epidemic abortion and respiratory syndrome (PEARS), is related to LDV and EAV.
Molecular Epidemiology and Genetic Characterization of Equine Arteritis Virus Isolates Associated with the 2006/2007 Multi-State Disease Occurrence in the USA.
ORF1a-encoded replicase subunits are involved in the membrane association of the arterivirus replication complex.
Processing of the equine arteritis virus replicase ORF1b protein: identification of cleavage products containing the putative viral polymerase and helicase domains.
Proteolytic processing of the replicase ORF1a protein of equine arteritis virus.
The arterivirus Nsp2 protease. An unusual cysteine protease with primary structure similarities to both papain-like and chymotrypsin-like proteases.
Variability of non-structural proteins of equine arteritis virus during persistent infection of the stallion.
Arthralgia
Antibody to parvovirus B19 nonstructural protein is associated with chronic arthralgia in patients with chronic fatigue syndrome/myalgic encephalomyelitis.
Haemolytic anaemia precipitated by dengue fever.
Arthritis
A case of macrophage activation syndrome in a patient with anti-synthetase syndrome.
Antisynthetase Syndrome with Anti-Jo1 Antibodies in 48 Patients: Pulmonary Involvement Predicts Disease-modifying Antirheumatic Drug Use.
Clinical features of anti-synthetase syndrome associated interstitial lung disease: a retrospective cohort in China.
Development of antibodies to the nonstructural protein NS1 of parvovirus B19 during acute symptomatic and subclinical infection in pregnancy: implications for pathogenesis doubtful.
Human parvovirus B19 transgenic mice become susceptible to polyarthritis.
Persistence of parvovirus B19 DNA in synovium of patients with haemophilic arthritis.
Recent advances in the role of RNA-binding protein, tristetraprolin, in arthritis.
The Diagnosis and Treatment of Antisynthetase Syndrome.
Viral arthritis.
[Antisynthetase syndrome: a retrospective study of 14 patients].
Arthritis, Rheumatoid
Anti-human parvovirus B19 nonstructural protein antibodies in patients with rheumatoid arthritis.
Human parvovirus B19 transgenic mice become susceptible to polyarthritis.
Infectious Rice Body Formation in a Patient with Anti-aminoacyl-t RNA Synthetase Syndrome: A Case Report.
Sensitivity and specificity of anti-Jo-1 antibodies in autoimmune diseases with myositis.
Serum and synovial fluid concentrations of cold-inducible RNA-binding protein in patients with rheumatoid arthritis.
Targeting Tristetraprolin Expression or Functional Activity Regulates Inflammatory Response Induced by MSU Crystals.
The RNA polymerase I-specific transcription initiation factor UBF is associated with transcriptionally active and inactive ribosomal genes.
Asthma
Theophylline inhibits the production of nitric oxide by peripheral blood mononuclear cells from patients with asthma.
Asymptomatic Infections
Development of antibodies to the nonstructural protein NS1 of parvovirus B19 during acute symptomatic and subclinical infection in pregnancy: implications for pathogenesis doubtful.
Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo'.
Ataxia
High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma.
Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability.
Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.
Atherosclerosis
Endothelial HuR deletion reduces the expression of proatherogenic molecules and attenuates atherosclerosis.
Proatherogenic stimuli induce HuR in atherosclerosis through MAPK/ErK pathway.
RNA polymerase and protein kinase activities of aortic nuclei during early atherogenesis.
The Role of PB1 Domain Proteins in Endothelial Cell Dysfunction and Disease.
Atrial Fibrillation
Cold-inducible RNA-binding protein modulates atrial fibrillation onset by targeting multiple ion channels.
Atypical Squamous Cells of the Cervix
Meiotic silencing in the homothallic fungus Gibberella zeae.
Neurospora spore killers Sk-2 and Sk-3 suppress meiotic silencing by unpaired DNA.
Autoimmune Diseases
A case of macrophage activation syndrome in a patient with anti-synthetase syndrome.
Arid5a-deficient mice are highly resistant to bleomycin-induced lung injury.
Developmental characterization of a Drosophila RNA-binding protein homologous to the human systemic lupus erythematosus-associated La/SS-B autoantigen.
Molecular control of Tfh-cell differentiation by Roquin family proteins.
Recently characterised autoantibodies and their clinical significance.
The roles of hnRNP A2/B1 in RNA biology and disease.
Azoospermia
A novel nucleocytoplasmic shuttling sequence of DAZAP1, a testis-abundant RNA-binding protein.
A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis.
Caenorhabditis elegans homologue of the human azoospermia factor DAZ is required for oogenesis but not for spermatogenesis.
Genomic structure and transcript variants of the bovine DAZL gene.
Oncogenic Role of BOLL in Colorectal Cancer.
Bacterial Infections
The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection.
Blast Crisis
High levels of the BCR/ABL oncoprotein are required for the MAPK-hnRNP-E2 dependent suppression of C/EBPalpha-driven myeloid differentiation.
Regulation of myeloid leukaemia by the cell-fate determinant Musashi.
Blister
Ptbp1 and Exosc9 knockdowns trigger skin stability defects through different pathways.
Bloom Syndrome
BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription.
Bluetongue
A comparison of the nucleotide sequences of cognate NS2 genes of three different orbiviruses.
A differential ELISA based on recombinant immunodominant epitopes of the gE gene of SHV-1 in a baculovirus-insect cell system to discriminate between pigs infected naturally with pseudorabies and vaccinated pigs.
Analysis of murine B-cell epitopes on bluetongue virus 12 nonstructural protein 1.
Assembly of five bluetongue virus proteins expressed by recombinant baculoviruses: inclusion of the largest protein VP1 in the core and virus-like proteins.
Baculovirus-expressed nonstructural protein NS2 of bluetongue virus induces a cytotoxic T-cell response in mice which affords partial protection.
Bluetongue virus nonstructural protein NS3/NS3a is not essential for virus replication.
Bluetongue virus-17 fusion protein ns1 expressed in Escherichia coli by pUC vectors.
CD8 T Cell Responses to an Immunodominant Epitope within the Nonstructural Protein NS1 Provide Wide Immunoprotection against Bluetongue Virus in IFNAR-/- Mice.
Characterization of a nonstructural phosphoprotein of two orbiviruses.
Deletion and mutational analyses of bluetongue virus NS2 protein indicate that the amino but not the carboxy terminus of the protein is critical for RNA-protein interactions.
Evidence for genetic relationship between RNA and DNA viruses from the sequence homology of a putative polymerase gene of bluetongue virus with that of vaccinia virus: conservation of RNA polymerase genes from diverse species.
Expression of a full-length nonstructural protein NS1 of bluetongue virus serotype 17 in Escherichia coli.
Expression of largest RNA segment and synthesis of VP1 protein of bluetongue virus in insect cells by recombinant baculovirus: association of VP1 protein with RNA polymerase activity.
In situ structures of RNA-dependent RNA polymerase inside bluetongue virus before and after uncoating.
In vitro phosphorylation and purification of a nonstructural protein of bluetongue virus with affinity for single-stranded RNA.
Localization of the nonstructural protein NS1 in bluetongue virus-infected cells and its presence in virus particles.
Localization of the single-stranded RNA-binding domains of bluetongue virus nonstructural protein NS2.
Multimers of the bluetongue virus nonstructural protein, NS2, possess nucleotidyl phosphatase activity: similarities between NS2 and rotavirus NSP2.
Mutation of either of two cysteine residues or deletion of the amino or carboxy terminus of nonstructural protein NS1 of bluetongue virus abrogates virus-specified tubule formation in insect cells.
Nucleotide and deduced amino acid sequence of the nonstructural phosphoprotein, NS2, of bluetongue virus serotype 17: comparison to two isolates of serotype 10.
Nucleotide and deduced amino acid sequence of the nonstructural protein, NS1, of the US bluetongue virus serotype 17.
Nucleotide sequence of the genome segment encoding nonstructural protein NS1 of bluetongue virus serotype 20 from Australia.
Primer-independent RNA sequencing with bacteriophage phi6 RNA polymerase and chain terminators.
Purified recombinant bluetongue virus VP1 exhibits RNA replicase activity.
Release of bluetongue virus-like particles from insect cells is mediated by BTV nonstructural protein NS3/NS3A.
Sequence analyses and antigenic epitope mapping of the putative RNA-directed RNA polymerase of five U.S. bluetongue viruses.
Specific binding of Bluetongue virus NS2 to different viral plus-strand RNAs.
The complete sequence of genome segment 8 of bluetongue virus, serotype 1, which encodes the nonstructural protein, NS2.
The effect of temperature on the in vitro transcriptase reaction of bluetongue virus, epizootic haemorrhagic disease virus and African horsesickness virus.
The identification of factors capable of reversing the core-mediated inhibition of the bluetongue virus transcriptase.
The in vitro activation and further characterization of the bluetongue virus-associated transcriptase.
Virus-derived tubular structure displaying foreign sequences on the surface elicit CD4+ Th cell and protective humoral responses.
Bone Resorption
Inhibition of Osteoclastogenesis by the RNA-Binding Protein QKI5: a Novel Approach to Protect from Bone Resorption.
Borna Disease
Evidence for translation of the Borna disease virus G protein by leaky ribosomal scanning and ribosomal reinitiation.
Functional characterization of the major and minor phosphorylation sites of the P protein of Borna disease virus.
RNA polymerase II-controlled expression of antigenomic RNA enhances the rescue efficacies of two different members of the Mononegavirales independently of the site of viral genome replication.
The Borna disease virus (BoDV) 2 nucleoprotein is a conspecific protein that enhances BoDV-1 RNA-dependent RNA polymerase activity.
Brain Injuries
Association between CIRP expression and hypoxic-ischemic brain injury in neonatal rats.
Cold-inducible RNA-binding protein contributes to intracerebral hemorrhage-induced brain injury via TLR4 signaling.
Brain Injuries, Traumatic
Neuroprotective effects of cold-inducible RNA-binding protein during mild hypothermia on traumatic brain injury.
Brain Ischemia
Cold-inducible RNA-binding protein mediates neuroinflammation in cerebral ischemia.
Effects of hypothermia and cerebral ischemia on cold-inducible RNA-binding protein mRNA expression in rat brain.
Musashi1 as a marker of reactive astrocytes after transient focal brain ischemia.
The Value of Extracellular Cold-Inducible RNA-Binding Protein (eCIRP) in Predicting the Severity and Prognosis of Patients After Cardiac Arrest: A Preliminary Observational Study.
Brain Neoplasms
A Novel Mutation in Brain Tumor Causes Both Neural Over-Proliferation and Neurodegeneration in Adult Drosophila.
Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition.
Cold-inducible RNA-binding protein (CIRBP) as a biomarker to predict recurrence of brain metastases.
Expression of the Neural RNA-binding protein Musashi1 in pediatric brain tumors.
Invasive growth associated with Cold-Inducible RNA-Binding Protein expression drives recurrence of surgically resected brain metastases.
Multilayered gene control drives timely exit from the stem cell state in uncommitted progenitors during Drosophila asymmetric neural stem cell division.
Properties of RNA polymerase from a transplantable brain tumor.
RNA polymerase activity in homotransplanted rat brain tumors initially induced by ethylnitrosourea.
RNA polymerase activity in human brain tumors.
The tumour suppressor brain tumour (Brat) regulates linker histone dBigH1 expression in the Drosophila female germline and the early embryo.
Breast Neoplasms
Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing.
Circular RNA La-related RNA-binding protein 4 correlates with reduced tumor stage, as well as better prognosis, and promotes chemosensitivity to doxorubicin in breast cancer.
Clinicopathological Significance of TARBP2, APP, and ZNF395 in Breast Cancer.
Cold-inducible RNA-binding protein contributes to human antigen R and cyclin E1 deregulation in breast cancer.
Collagen-induced differential expression of an RNA polymerase subunit by breast cancer cells.
Correction: Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer.
Double-stranded RNA-binding protein regulates vascular endothelial growth factor mRNA stability, translation, and breast cancer angiogenesis.
EMP3 negatively modulates breast cancer cell DNA replication, DNA damage repair, and stem-like properties.
Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement.
Epigenetic inactivation of the splicing RNA-binding protein CELF2 in human breast cancer.
Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer.
Functional analysis of an alternatively spliced estrogen receptor lacking exon 4 isolated from MCF-7 breast cancer cells and meningioma tissue.
Genistein suppresses the invasive potential of human breast cancer cells through transcriptional regulation of metalloproteinases and their tissue inhibitors.
High RBM3 expression in prostate cancer independently predicts a reduced risk of biochemical recurrence and disease progression.
HuR and the bioenergetic signature of breast cancer: a low tumor expression of the RNA-binding protein predicts a higher risk of disease recurrence.
Integrated Regulation of HuR by Translation Repression and Protein Degradation Determines Pulsatile Expression of p53 Under DNA Damage.
Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer.
Mammary epithelial morphogenesis and early breast cancer. Evidence of involvement of basal components of the RNA Polymerase I transcription machinery.
MiR-421 promotes the development of osteosarcoma by regulating MCPIP1 expression.
Msi1 promotes breast cancer metastasis by regulating invadopodia-mediated extracellular matrix degradation via the Timp3-Mmp9 pathway.
Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer.
Nuclear expression of the RNA-binding protein RBM3 is associated with an improved clinical outcome in breast cancer.
Pharmacogenetics of the anti-HCV drug sofosbuvir: a preliminary study.
PSF Promotes ER-Positive Breast Cancer Progression via Posttranscriptional Regulation of ESR1 and SCFD2.
PTEN expression is upregulated by a RNA-binding protein RBM38 via enhancing its mRNA stability in breast cancer.
Regulation of Mcl-1 by SRSF1 and SRSF5 in cancer cells.
RNA-binding protein CELF2 inhibits breast cancer cell invasion and angiogenesis by downregulating NFATc1.
RNA-binding protein CUGBP1 controls the differential INSR splicing in molecular subtypes of breast cancer cells and affects cell aggressiveness.
RNA-Binding Protein Dnd1 Promotes Breast Cancer Apoptosis by Stabilizing the Bim mRNA in a miR-221 Binding Site.
RNA-binding protein NONO promotes breast cancer proliferation by post-transcriptional regulation of SKP2 and E2F8.
RNA-binding protein QKI suppresses breast cancer via RASA1/MAPK signaling pathway.
RNA-binding protein RNPC1: acting as a tumor suppressor in breast cancer.
RNA-binding protein SAMD4A inhibits breast tumor angiogenesis by modulating the balance of angiogenesis program.
RNPC1 enhances progesterone receptor functions by regulating its mRNA stability in breast cancer.
Sam68 Mediates the Activation of Insulin and Leptin Signalling in Breast Cancer Cells.
Sam68 up-regulation correlates with, and its down-regulation inhibits, proliferation and tumourigenicity of breast cancer cells.
Tamoxifen represses alcohol-induced transcription of RNA polymerase III-dependent genes in breast cancer cells.
Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis.
The androgen receptor mRNA.
The RNA-binding protein HuR regulates GATA3 mRNA stability in human breast cancer cell lines.
The RNA-binding protein Musashi 1 stabilizes the oncotachykinin 1 mRNA in breast cancer cells to promote cell growth.
The RNA-binding protein RBPMS1 represses AP-1 signaling and regulates breast cancer cell proliferation and migration.
Transcriptional features of fractionated human breast tumor chromatin.
[Relationship between expression of RBM38 and distant metastasis and prognosis of breast cancer].
Bronchiolitis
Molecular mechanisms of respiratory syncytial virus replication: a guide for the development of antivirals.
Bronchitis
Comparative analysis of complete genome sequences of three avian coronaviruses reveals a novel group 3c coronavirus.
Complete sequence (20 kilobases) of the polyprotein-encoding gene 1 of transmissible gastroenteritis virus.
Coronavirus infectious bronchitis virus non-structural proteins 8 and 12 form stable complex independent of the non-translated regions of viral RNA and other viral proteins.
Coronavirus NSP6 restricts autophagosome expansion.
Crystallization and preliminary X-ray diffraction studies of infectious bronchitis virus nonstructural protein 9.
Kidney Cell-Adapted Infectious Bronchitis ArkDPI Vaccine is Stable and Protective.
Kidney Cell-Adapted Infectious Bronchitis Virus Arkansas Delmarva Poultry Industry Vaccine Confers Effective Protection Against Challenge.
Molecular characterization of infectious bronchitis virus based on RNA-dependent RNA polymerase gene.
Nucleotide sequence of the E2-peplomer protein gene and partial nucleotide sequence of the upstream polymerase gene of transmissible gas gastroenteritis virus (Miller strain).
Nucleotide sequence of the human coronavirus 229E RNA polymerase locus.
Proteolytic processing of the polyprotein encoded by ORF1b of the coronavirus infectious bronchitis virus (IBV).
Purification, crystallization and preliminary X-ray analysis of nonstructural protein 2 (nsp2) from avian infectious bronchitis virus.
Reverse transcription loop-mediated isothermal amplification for the rapid detection of infectious bronchitis virus in infected chicken tissues.
Sequence of the S gene from a virulent British field isolate of transmissible gastroenteritis virus.
Bunyaviridae Infections
Suppression of the IFN-? and -? Induction through Sequestering IRF7 into Viral Inclusion Bodies by Nonstructural Protein NSs in Severe Fever with Thrombocytopenia Syndrome Bunyavirus Infection.
Burkitt Lymphoma
Preparative high-resolution two-dimensional electrophoresis enables the identification of RNA polymerase B transcription factor 3 as an apoptosis-associated protein in the human BL60-2 Burkitt lymphoma cell line.
Calcinosis
Distinctive cutaneous and systemic features associated with specific antimyositis antibodies in adults with dermatomyositis: a prospective multicentric study of 117 patients.
Caliciviridae Infections
Incidence of and factors associated with false positives in laboratory diagnosis of norovirus infection by amplification of the RNA-dependent RNA polymerase gene.
Candidiasis
Post-translational modification directs nuclear and hyphal tip localization of Candida albicans mRNA-binding protein Slr1.
Carcinogenesis
A mirror of two faces: Lin28 as a master regulator of both miRNA and mRNA.
Abnormal expression of TFIIIB subunits and RNA Pol III genes is associated with hepatocellular carcinoma.
Alpha CP-4, encoded by a putative tumor suppressor gene at 3p21, but not its alternative splice variant alpha CP-4a, is underexpressed in lung cancer.
An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates.
Anticarcinogenic effects of retinoids in animals.
Applying a high-throughput fluorescence polarization assay for the discovery of chemical probes blocking La:RNA interactions in vitro and in cells.
Carcinoid tumour associated with enterovirus infection.
CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness.
Clinical Significance of Methylation and Reduced Expression of the Quaking Gene in Colorectal Cancer.
Differential Regulation of
Differential regulation of autophagy by STAU1 in alveolar rhabdomyosarcoma and non-transformed skeletal muscle cells.
Distinct roles for the RNA-binding protein Staufen1 in prostate cancer.
Does Lin28 Antagonize miRNA-Mediated Repression by Displacing miRISC from Target mRNAs?
Dysregulated transcription across diverse cancer types reveals the importance of RNA-binding protein in carcinogenesis.
Epstein-Barr virus induces cellular transcription factors to allow active expression of EBER genes by RNA polymerase III.
Expression of exogenous LIN28 contributes to proliferation and survival of mouse primary cortical neurons in vitro.
Finding, Conducting, and Nurturing Science: A Virologist's Memoir.
FUS-mediated regulation of alternative RNA processing in neurons: insights from global transcriptome analysis.
Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11).
Genetic variants of the LIN28B gene predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.
Genome-wide analysis of Musashi-2 targets reveals novel functions in governing epithelial cell migration.
Genomic analyses of musashi1 downstream targets show a strong association with cancer-related processes.
Hepatitis B virus X protein enhances androgen receptor-responsive gene expression depending on androgen level.
Hepatitis C virus nonstructural protein NS(3) and telomerase activity.
Heterogeneous Nuclear Ribonucleoprotein A2/B1 Regulates the Selfrenewal and Pluripotency of Human Embryonic Stem Cells via the Control of the G1/S Transition.
hnRNP A1 antagonizes cellular senescence and senescence-associated secretory phenotype via regulation of SIRT1 mRNA stability.
HnRNP-L promotes prostate cancer progression by enhancing cell cycling and inhibiting apoptosis.
Human T-cell leukemia virus type 1 Tax and cellular transformation.
HuR cytoplasmic expression is associated with increased cyclin A expression and inferior disease-free survival in patients with gastrointestinal stromal tumours (GISTs).
HuR cytoplasmic expression is associated with increased cyclin A expression and poor outcome with upper urinary tract urothelial carcinoma.
Identification of RNA-binding proteins that partner with Lin28a to regulate Dnmt3a expression.
IGF2BP3 facilitates cell proliferation and tumorigenesis via modulation of JAK/STAT signalling pathway in human bladder cancer.
Immunohistochemical Analysis Revealed a Correlation between Musashi-2 and Cyclin-D1 Expression in Patients with Oral Squamous Cells Carcinoma.
Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis.
Inhibition of chemical carcinogenesis: increased activity of soluble RNA polymerase in the liver of rats protected against 3'MeDAB hepatocarcinogenesis by dietary chloramphenicol.
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma.
Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors.
Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development.
KH-type splicing regulatory protein (KHSRP) contributes to tumorigenesis by promoting miR-26a maturation in small cell lung cancer.
LIN28 Binds Messenger RNAs at GGAGA Motifs and Regulates Splicing Factor Abundance.
LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans.
LIN28 Expression in Rat Spinal Cord After Injury.
Msi1 promotes tumor progression by epithelial-to-mesenchymal transition in cervical cancer.
Musashi-1, an RNA-binding protein, is indispensable for survival of photoreceptors.
Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis.
Nucleolin Promotes IRES-Driven Translation of Foot-and-Mouth Disease Virus by Supporting the Assembly of Translation Initiation Complexes.
Original Article/Liver hMex-3A is associated with poor prognosis and contributes to the progression of hepatocellular carcinoma.
Overexpression of Lin28b in Neural Stem Cells is Insufficient for Brain Tumor Formation, but Induces Pathological Lobulation of the Developing Cerebellum.
Overexpression of Musashi-1 protein is associated with progression and poor prognosis of gastric cancer.
Prognostic Value of the Expression of DNA Repair-Related Biomarkers Mediated by Alcohol in Gastric Cancer Patients.
Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells.
RALY may cause an aggressive biological behavior and a dismal prognosis in non-small-cell lung cancer.
Reversible acetylation of Lin28 mediated by PCAF and SIRT1.
RNA-binding protein MSI2 isoforms expression and regulation in progression of triple-negative breast cancer.
RNase L downmodulation of the RNA-binding protein, HuR, and cellular growth.
Role of RNA-binding protein 5 in the diagnosis and chemotherapeutic response of lung cancer.
Role of the RNA-binding protein HuR in colon carcinogenesis.
Selective inhibition of RNA polymerase activity in rat liver nuclei by 4-(dimethylamino) azobenzene, and effect of nitrofurans on liver RNA metabolism associated with prevention of carcinogenesis.
Serine-phosphorylated STAT3 promotes tumorigenesis via modulation of RNA polymerase transcriptional activity.
Structure of Musashi1 in a complex with target RNA: the role of aromatic stacking interactions.
The Aberrant Expression of MicroRNA-125a-5p/IGF2BP3 Axis in Advanced Gastric Cancer and Its Clinical Relevance.
The Grainyhead transcription factor Grhl3/Get1 suppresses miR-21 expression and tumorigenesis in skin: modulation of the miR-21 target MSH2 by RNA-binding protein DND1.
The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis.
The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells.
The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits.
The oncogenic RNA-binding protein Musashi1 is regulated by HuR via mRNA translation and stability in glioblastoma cells.
The oncogenic RNA-binding protein Musashi1 is regulated by tumor suppressor miRNAs.
The pluripotency factor LIN28B is involved in oral carcinogenesis and associates with tumor aggressiveness and unfavorable prognosis.
The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer.
The RNA-binding protein QKI suppresses tumorigenesis of clear cell renal cell carcinoma by regulating the expression of HIF-1?.
The RNA-binding protein Sam68 regulates tumor cell viability and hepatic carcinogenesis by inhibiting the transcriptional activity of FOXOs.
The RNA-binding protein SORBS2 suppresses hepatocellular carcinoma tumourigenesis and metastasis by stabilizing RORA mRNA.
The role of RNA-binding protein tristetraprolin in cancer and immunity.
The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis.
The role of the RNA-binding protein Sam68 in mammary tumourigenesis.
Transcriptional mutagenesis and its potential roles in the etiology of cancer and bacterial antibiotic resistance.
Ubiquitin-Proteasome System Regulation of an Evolutionarily Conserved RNA Polymerase II-Associated Factor 1 Involved in Pancreatic Oncogenesis.
Carcinoid Tumor
Carcinoid tumour associated with enterovirus infection.
Carcinoma
A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function.
Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study.
Analysis of Tertiary Interactions between SART3 and U6 Small Nuclear RNA Using Modified Nanocapillaries.
Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L.
Autoantibodies against the Hel-N1 RNA-binding protein among patients with lung carcinoma: an association with type I anti-neuronal nuclear antibodies.
Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation.
Characterization of self-assembled virus-like particles of merkel cell polyomavirus.
Characterization of squamous cell carcinoma in an organotypic culture via subsurface non-linear optical molecular imaging.
Cytoplasmic steroid effects on nuclear RNA polymerase activity in canine mammary carcinomas.
De Novo RNA Synthesis by RNA-Dependent RNA Polymerase Activity of Telomerase Reverse Transcriptase.
Detection of hepatitis C virus NS5 protein and genome in Chinese carcinoma of the extrahepatic bile duct and its significance.
Different Wnt-5A gene expressions in the renal cell carcinoma GRC-1 cell line during the cell cycle.
Expression of cold-inducible RNA-binding protein (CIRP) in renal cell carcinoma and the effect of CIRP downregulation cell proliferation and chemosensitivity to gemcitabine.
Expression of Cold-Inducible RNA-Binding Protein in Normal Skin, Actinic Keratosis and Squamous Cell Carcinoma.
Expression of RNA-binding protein LIN28 in classic gastric hepatoid carcinomas, gastric fetal type gastrointestinal adenocarcinomas, and hepatocellular carcinomas: An immunohistochemical study with comparison to SALL4, alpha-fetoprotein, glypican-3, and Hep Par1.
Expression of the oncofetal protein IGF2BP3 in endometrial clear cell carcinoma: assessment of frequency and significance.
Expression of the RNA-binding protein IMP1 correlates with poor prognosis in ovarian carcinoma.
Genomic Fabric Remodeling in Metastatic Clear Cell Renal Cell Carcinoma (ccRCC): A New Paradigm and Proposal for a Personalized Gene Therapy Approach.
Genotoxic stress causes the accumulation of the splicing regulator Sam68 in nuclear foci of transcriptionally active chromatin.
Human papillomavirus type 33 in a tonsillar carcinoma generates its putative E7 mRNA via two E6* transcript species which are terminated at different early region poly(A) sites.
Implication of RNA-binding protein La in proliferation, migration and invasion of lymph node-metastasized hypopharyngeal SCC cells.
In-vitro inhibition of spring viremia of carp virus replication by RNA interference targeting the RNA-dependent RNA polymerase gene.
Inhibition of nuclear DNA-dependent RNA polymerases from mouse ascites tumors and liver by glycerol.
Inhibition of RNA-Binding Protein Musashi-1 Suppresses Malignant Properties and Reverses Paclitaxel Resistance in Ovarian Carcinoma.
Insulin-like Growth Factor Messenger RNA-binding Protein 3 Expression Helps Prognostication in Patients with Upper Tract Urothelial Carcinoma.
Integrated Analysis of the Prognosis-Associated RNA-Binding Protein Genes and Candidate Drugs in Renal Papillary Cell Carcinoma.
KOC (K homology domain containing protein overexpressed in cancer): a novel molecular marker that distinguishes between benign and malignant lesions of the pancreas.
LncRNA OIP5-AS1/cyrano sponges RNA-binding protein HuR.
MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma.
Muscle-Specific FXR1 Isoforms in Squamous Cell Cancer.
Parameters of RNA-dependent RNA polymerase activity in a mengovirus-infected Ehrlich ascites carcinoma cell-free system.
Prognostic value of antibodies to Merkel cell polyomavirus T-Antigens and VP1 protein in Merkel cell carcinoma patients.
Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157.
Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma.
RNA-binding protein CELF1 promotes tumor growth and alters gene expression in oral squamous cell carcinoma.
RNA-Binding Protein IGF2BP1 in Cutaneous Squamous Cell Carcinoma.
RNA-binding protein QKI-5 inhibits the proliferation of clear cell renal cell carcinoma via post-transcriptional stabilization of RASA1 mRNA.
RNA-binding protein SORBS2 suppresses clear cell renal cell carcinoma metastasis by enhancing MTUS1 mRNA stability.
Role of the RNA-binding protein HuR in colon carcinogenesis.
Role of the RNA-binding protein HuR in human renal cell carcinoma.
The expression of RNA-binding protein RBM38 decreased in renal cell carcinoma and represses renal cancer cell proliferation, migration, and invasion.
The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2.
The RNA-binding protein PCBP2 facilitates gastric carcinoma growth by targeting miR-34a.
The RNA-binding protein QKI suppresses tumorigenesis of clear cell renal cell carcinoma by regulating the expression of HIF-1?.
The RNA-binding protein RBM47 inhibits non-small cell lung carcinoma metastasis through modulation of AXIN1 mRNA stability and Wnt/?-catentin signaling.
The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells.
Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma.
Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells.
Use of IMP3 in identification of carcinoma in fine needle aspiration biopsies of pancreas.
von Hippel-Lindau tumor suppressor gene-dependent mRNA stabilization of the survival factor parathyroid hormone-related protein in human renal cell carcinoma by the RNA-binding protein HuR.
Zinc finger RNA-binding protein promotes non-small-cell carcinoma growth and tumor metastasis by targeting the Notch signaling pathway.
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program.
[RNA polymerase activity of Ehrlich ascites carcinoma nuclei in relation to the mechanism of action of N-alkyl-N-nitrosourea]
Carcinoma, Ductal
Immunohistochemical evaluation of reverse transcriptase in breast carcinoma with polyclonal antibodies raised in rabbit.
Carcinoma, Ehrlich Tumor
DNA dependent RNA polymerase from Ehrlich ascites tumor cells. II. Factors stimulating the activity of RNA polymerase II.
DNA dependent RNA polymerase from ehrlich ascites tumor cells. IV. A novel protein repressing RNA polymerase II.
DNA dependent RNA polymerase from Ehrlich ascites tumor cells. V. Characterization of a factor repressing RNA polymerase II as a ribonucleoprotein.
DNA-dependent RNA polymerase from Ehrlich ascites tumor cells. I. Partial purification and characterization of RNA polymerase II.
Effect of cis-diamminedichloroplatinum(II) and other platinum compounds on the RNA polymerase reaction.
Inhibition of ribonucleases by ribonucleotides and transition state analogs in cell-free extracts from Ehrlich ascites tumor cells.
Mouse DNA polymerase accompanied by a novel RNA polymerase activity: purification and partial characterization.
Partial purification and characterization of RNA polymerase from nuclei of Ehrlich ascites tumor cells.
Study of the loosely bound non-histone chromatin proteins. Stimulation of deoxyribonucleic acid-templated ribonucleic acid synthesis by a specific deoxyribonucleic acid-binding phosphoprotein fraction.
Carcinoma, Embryonal
c-jun inhibited the alternative splicing of neuron-specific amyloid precursor protein, but stimulated the non-neuron type one in P19 EC cells.
Carcinoma, Hepatocellular
A comparative study of "soluble" RNA polymerase activity of Zajdela hepatoma ascites cells and calf thymus.
A family of IGF-II mRNA binding proteins (IMP) involved in RNA trafficking.
Aberrant expression of fetal RNA-binding protein p62 in liver cancer and liver cirrhosis.
Circ-MALAT1 Functions as Both an mRNA Translation Brake and a microRNA Sponge to Promote Self-Renewal of Hepatocellular Cancer Stem Cells.
Cloning and characterization of a novel 90 kDa 'companion' auto-antigen of p62 overexpressed in cancer.
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus.
Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells.
Cyclooxygenase-2 is a target of microRNA-16 in human hepatoma cells.
Expression of Concern: Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells.
Expression of RNA-binding protein LIN28 in classic gastric hepatoid carcinomas, gastric fetal type gastrointestinal adenocarcinomas, and hepatocellular carcinomas: An immunohistochemical study with comparison to SALL4, alpha-fetoprotein, glypican-3, and Hep Par1.
Expression of the Musashi1 gene encoding the RNA-binding protein in human hepatoma cell lines.
HCV NS5A activates the mammalian target of rapamycin (mTOR) pathway contributing to cell survival via disrupting the interaction between FK506-binding protein 38 (FKBP38) and mTOR.
Hepatitis B virus X protein promotes interleukin-7 receptor expression via NF-?B and Notch1 pathway to facilitate proliferation and migration of hepatitis B virus-related hepatoma cells.
Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis.
Hepatitis C virus replication is modulated by the interaction of non-structural protein NS5B and fatty acid synthase.
High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma.
Hormonal effect on nucleolar RNA polymerase in normal liver and hepatoma cells.
Identification and characterization of a novel protein that regulates RNA-protein interaction.
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
Immunolocalization of a subnucleolar nucleoprotein complex containing RNA polymerase 1 in ascites hepatoma cells using monoclonal antibodies.
Multi-enzyme-targeted chemotherapy by acivicin and actinomycin.
Protective effect of the RNA-binding protein RBM10 in hepatocellular carcinoma.
RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts.
Real-world safety and efficacy of sofosbuvir and ledipasvir for elderly patients.
Reversible inhibition of induction of mengovirus RNA polymerase and of virus maturation in Novikoff rat hepatoma cells by phenethyl alcohol.
RNA-binding protein AUF1 suppresses miR-122 biogenesis by down-regulating Dicer1 in hepatocellular carcinoma.
RNA-binding protein Dnd1 inhibits epithelial-mesenchymal transition and cancer stem cell-related traits on hepatocellular carcinoma cells.
RNA-binding protein insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor invasion and predicts early recurrence and poor prognosis in hepatocellular carcinoma.
RNA-binding protein RBM6 acts as a tumor suppressor gene to inhibit the progression of hepatocellular carcinoma.
RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells.
Role of La autoantigen and polypyrimidine tract-binding protein in HCV replication.
Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma.
The hepatitis C viral nonstructural protein 5A stabilizes growth-regulatory human transcripts.
The RNA-binding protein RBM3 promotes cell proliferation in hepatocellular carcinoma by regulating circular RNA SCD-circRNA 2 production.
The RNA-binding protein SORBS2 suppresses hepatocellular carcinoma tumourigenesis and metastasis by stabilizing RORA mRNA.
Transcriptionally active RNA polymerases from Morris hepatomas and rat liver. Elucidation of the mechanism for the preferential increase in the tumour RNA polymerase I.
Utilization of RNA polymerase I promoter and terminator sequences to develop a DNA transfection system for the study of hepatitis C virus internal ribosomal entry site-dependent translation.
Withdrawal: Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells.
[Effect of 10-hydroxycamptothecin on nuclear RNA polymerase activity in hepatoma cells in mice]
[Inhibition of parvovirus H-1 on transplantable human hepatoma and its histological and histobiochemical studies]
[Significance of a novel fetal RNA-binding protein p62 expression in hepatocellular carcinoma]
Carcinoma, Lobular
Immunohistochemical evaluation of reverse transcriptase in breast carcinoma with polyclonal antibodies raised in rabbit.
Carcinoma, Merkel Cell
Characterization of self-assembled virus-like particles of merkel cell polyomavirus.
Prognostic value of antibodies to Merkel cell polyomavirus T-Antigens and VP1 protein in Merkel cell carcinoma patients.
Carcinoma, Neuroendocrine
Extrapulmonary small cell carcinomas express K homology domain containing protein overexpressed in cancer, but carcinoid tumors do not.
High-grade neuroendocrine carcinomas of the lung express K homology domain containing protein overexpressed in cancer but carcinoid tumors do not.
Carcinoma, Non-Small-Cell Lung
Expression profile, clinical significance, and biological function of insulin-like growth factor 2 messenger RNA-binding proteins in non-small cell lung cancer.
MUC1-C Induces the LIN28B?LET-7?HMGA2 Axis to Regulate Self-Renewal in NSCLC.
Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC).
RNA-binding protein KHSRP promotes tumor growth and metastasis in non-small cell lung cancer.
The Expression of RNA-Binding Protein HuR in Non-Small Cell Lung Cancer Correlates with Vascular Endothelial Growth Factor-C Expression and Lymph Node Metastasis.
The oncogenic RNA-binding protein SRSF1 regulates LIG1 in non-small cell lung cancer.
The RNA-binding protein HuR stabilizes the cytosolic phospholipase A2{alpha} mRNA under interleukin-1{beta} treatment in non-small cell lung cancer A549 cells.
The RNA-binding protein RBM47 inhibits non-small cell lung carcinoma metastasis through modulation of AXIN1 mRNA stability and Wnt/?-catentin signaling.
The RNA-binding protein Sam68 is critical for non-small cell lung cancer cell proliferation by regulating Wnt/?-catenin pathway.
Carcinoma, Ovarian Epithelial
Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer.
Carcinoma, Renal Cell
Different Wnt-5A gene expressions in the renal cell carcinoma GRC-1 cell line during the cell cycle.
Expression of cold-inducible RNA-binding protein (CIRP) in renal cell carcinoma and the effect of CIRP downregulation cell proliferation and chemosensitivity to gemcitabine.
Genomic Fabric Remodeling in Metastatic Clear Cell Renal Cell Carcinoma (ccRCC): A New Paradigm and Proposal for a Personalized Gene Therapy Approach.
Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells.
RNA-binding protein QKI-5 inhibits the proliferation of clear cell renal cell carcinoma via post-transcriptional stabilization of RASA1 mRNA.
RNA-binding protein SORBS2 suppresses clear cell renal cell carcinoma metastasis by enhancing MTUS1 mRNA stability.
Role of the RNA-binding protein HuR in human renal cell carcinoma.
The expression of RNA-binding protein RBM38 decreased in renal cell carcinoma and represses renal cancer cell proliferation, migration, and invasion.
The RNA-binding protein QKI suppresses tumorigenesis of clear cell renal cell carcinoma by regulating the expression of HIF-1?.
von Hippel-Lindau tumor suppressor gene-dependent mRNA stabilization of the survival factor parathyroid hormone-related protein in human renal cell carcinoma by the RNA-binding protein HuR.
Carcinoma, Squamous Cell
Characterization of squamous cell carcinoma in an organotypic culture via subsurface non-linear optical molecular imaging.
Expression of Cold-Inducible RNA-Binding Protein in Normal Skin, Actinic Keratosis and Squamous Cell Carcinoma.
MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma.
Muscle-Specific FXR1 Isoforms in Squamous Cell Cancer.
RNA-Binding Protein IGF2BP1 in Cutaneous Squamous Cell Carcinoma.
The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2.
Cardiac Conduction System Disease
Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy.
Cardiomegaly
A novel serum protein of molecular weight 182 kDa: a molecular marker for an early detection of increased left ventricular mass in patients with cardiac hypertrophy.
Biochemical correlates of cardiac hypertrophy. I. Experimental model; changes in heart weight, RNA content, and nuclear RNA polymerase activity.
Cardiac isoform of alpha-2 macroglobin, a novel serum protein, may induce cardiac hypertrophy in rats.
Catecholamine induced cardiac hypertrophy.
Direct injection and expression in vivo of full-length cDNA of the cardiac isoform of alpha-2 macroglobulin induces cardiac hypertrophy in the rat heart.
Enhanced myocardial RNA synthesis in spontaneously hypertensive rats possible role of high-mobility group non-histone proteins.
Programmed Cell Death 5 Provides Negative Feedback on Cardiac Hypertrophy Through the Stabilization of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2a Protein.
RNA polymerase and adenyl cyclase in cardiac hypertrophy and cardiomyopathy.
Cardiomyopathies
RNA polymerase and adenyl cyclase in cardiac hypertrophy and cardiomyopathy.
RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility.
Cardiomyopathy, Dilated
Increased Cardiac Arrhythmogenesis Associated With Gap Junction Remodeling With Upregulation of RNA-Binding Protein FXR1.
Rbm20-deficient cardiogenesis reveals early disruption of RNA processing and sarcomere remodeling establishing a developmental etiology for dilated cardiomyopathy.
RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.
Cardiovascular Diseases
Circular RNAs are a novel type of non-coding RNAs in ROS regulation, cardiovascular metabolic inflammations and cancers.
Switch to dolutegravir and unboosted atazanavir in HIV-1 infected patients with undetectable viral load and long exposure to antiretroviral therapy.
The Role of PB1 Domain Proteins in Endothelial Cell Dysfunction and Disease.
Cervical Intraepithelial Neoplasia
Enzyme-linked immunosorbent assay for p16(INK4a) - a new triage test for the detection of cervical intraepithelial neoplasia?
Chagas Disease
TcUBP-1, a developmentally regulated U-rich RNA-binding protein involved in selective mRNA destabilization in trypanosomes.
Chickenpox
RNA polymerase III and antiviral innate immune response.
Cholangiocarcinoma
MSI2 knockdown represses extrahepatic cholangiocarcinoma growth and invasion by inhibiting epithelial-mesenchymal transition.
Cholangitis, Sclerosing
Identification of beta-subunit of bacterial RNA-polymerase--a non-species-specific bacterial protein--as target of antibodies in primary biliary cirrhosis.
Cholera
Colloidal gold: a pluripotent receptor probe.
Foot-and-mouth disease virus VP1 protein fused with cholera toxin B subunit expressed in Chlamydomonas reinhardtii chloroplast.
In-silico prediction of dual function of DksA like hypothetical protein in V. cholerae O395 genome.
Multiplex polymerase chain reaction-based assay for the specific detection of toxin-producing Vibrio cholerae in fish and fishery products.
Post-transcriptional regulation of cholera toxin production in Vibrio cholerae by the stringent response regulator DksA.
Tracking the Elusive Function of Bacillus subtilis Hfq.
Chondrosarcoma
A renal cell carcinoma with EWSR1-TFE3 fusion gene.
Diagnostic Utility of Molecular Investigation in Extraskeletal Myxoid Chondrosarcoma.
Choriocarcinoma
Regulation of Mcl-1 by SRSF1 and SRSF5 in cancer cells.
Chronic Periodontitis
Differential expression of microRNAs let-7a, miR-125b, miR-100, and miR-21 and interaction with NF-kB pathway genes in periodontitis pathogenesis.
Periodontal pathogens in subgingival plaque of HIV-positive subjects with chronic periodontitis.
Ciliopathies
Role of the RNA-binding protein Bicaudal-C1 and interacting factors in cystic kidney diseases.
Classical Swine Fever
A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase.
An induced-fit de novo initiation mechanism suggested by a pestivirus RNA-dependent RNA polymerase.
Autophagy Induced by the N-Terminus of the Classic Swine Fever Virus Nonstructural Protein 5A Protein Promotes Viral Replication.
Baculovirus surface display of NS3 nonstructural protein of classical swine fever virus.
Cellular Hsp27 interacts with classical swine fever virus NS5A protein and negatively regulates viral replication by the NF-?B signaling pathway.
Characterisation of interaction between NS3 and NS5B protein of classical swine fever virus by deletion of terminal sequences of NS5B.
Characterization of classical swine fever virus (CSFV) nonstructural protein 3 (NS3) helicase activity and its modulation by CSFV RNA-dependent RNA polymerase.
Characterization of RNA-dependent RNA polymerase activity of CSFV NS5B proteins expressed in Escherichia coli.
Characterization of the N-terminal domain of classical swine fever virus RNA-dependent RNA polymerase.
Classical swine fever virus nonstructural protein p7 modulates infectious virus production.
Classical swine fever virus NS3 enhances RNA-dependent RNA polymerase activity by binding to NS5B.
Classical swine fever virus NS5B protein suppresses the inhibitive effect of NS5A on viral translation by binding to NS5A.
Classical swine fever virus NS5B-GFP fusion protein possesses an RNA-dependent RNA polymerase activity.
Classical Swine Fever Virus p7 Protein Interacts with Host Protein CAMLG and Regulates Calcium Permeability at the Endoplasmic Reticulum.
Classical swine fever virus p7 protein is a viroporin involved in virulence in swine.
Crystal Structure of Classical Swine Fever Virus NS5B Reveals a Novel N-Terminal Domain.
De novo RNA synthesis and homology modeling of the classical swine fever virus RNA polymerase.
De novo RNA synthesis by a recombinant classical swine fever virus RNA-dependent RNA polymerase.
Diagnostic evaluation of a real-time reverse transcriptase PCR assay for detection of classical swine fever virus.
Episodic adaptive diversification of classical swine fever virus RNA-dependent RNA polymerase NS5B.
Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase.
Inhibition of expression of rna polymerase with small interfering RNAs targeting a conserved motif in the respective viral genes in viruses of the family Flaviviridae.
Intra-host variation structure of classical swine fever virus NS5B in relation to antiviral therapy.
Molecular cloning and nucleotide sequence of the genome of hog cholera virus.
Mutational analysis of the GDD sequence motif of classical swine fever virus RNA-dependent RNA polymerases.
Phylogenetic comparison and molecular epidemiology of classical swine fever virus.
Porcine Mx1 Protein Inhibits Classical Swine Fever Virus Replication by Targeting Nonstructural Protein NS5B.
Processing of pestivirus polyprotein: cleavage site between autoprotease and nucleocapsid protein of classical swine fever virus.
Rapid detection of classical swine fever virus by a portable real-time reverse transcriptase PCR assay.
Real-time SPR characterization of the interactions between multi-epitope proteins and antibodies against classical swine fever virus.
RNA-dependent RNA polymerase activity of Classical swine fever virus NS5B protein expressed in natural host cells.
Selective stimulation of hepatitis C virus and pestivirus NS5B RNA polymerase activity by GTP.
Specific interaction between the classical swine fever virus NS5B protein and the viral genome.
The GTP binding sites interacted with RNA-dependent RNA polymerase of classical swine fever virus in de novo initiation.
The Network of Interactions Between Classical Swine Fever Virus Nonstructural Protein p7 and Host Proteins.
The RNA-dependent RNA polymerases of different members of the family Flaviviridae exhibit similar properties in vitro.
[A new enzyme immunoassay for the detection of antibodies against the bovine viral diarrhea virus]
Cleft Palate
The RNA-binding landscape of RBM10 and its role in alternative splicing regulation in models of mouse early development.
Clostridium Infections
Characterization of a Sugar-O-methyltransferase TiaS5 Affords New Tiacumicin Analogues with Improved Antibacterial Properties and Reveals Substrate Promiscuity.
Fidaxomicin: Difimicin; Lipiarmycin; OPT 80; OPT-80; PAR 101; PAR-101.
Cockayne Syndrome
Deficiency of the Cockayne syndrome B (CSB) gene aggravates the genomic instability caused by endogenous oxidative DNA base damage in mice.
Nucleotide excision repair and its interplay with transcription.
Oxidatively damaged DNA repair defect in cockayne syndrome and its complementation by heterologous repair proteins.
The Cockayne syndrome B protein, involved in transcription-coupled DNA repair, resides in an RNA polymerase II-containing complex.
Coinfection
Biological and Molecular Characteristics of a Novel Partitivirus Infecting the Edible Fungus Lentinula edodes.
Dengue virus and antiplatelet autoantibodies synergistically induce haemorrhage through Nlrp3-inflammasome and Fc?RIII.
Detection and characterization of astroviruses in dogs.
Diversity of the hepatitis C virus NS5B gene during HIV co-infection.
Emergence of unique variants and inter-genotype recombinants of human astroviruses infecting infants, children and adults in Kolkata, India.
Enzyme-linked immunosorbent assay specific to Dengue virus type 1 nonstructural protein NS1 reveals circulation of the antigen in the blood during the acute phase of disease in patients experiencing primary or secondary infections.
Feline calicivirus VP2 is involved in the self-assembly of the capsid protein into virus-like particles.
First Detection of Bat Astroviruses (BtAstVs) among Bats in Poland: The Genetic BtAstVs Diversity Reveals Multiple Co-Infection of Bats with Different Strains.
First Report of Cucurbit Chlorotic Yellows Virus affecting Watermelon in USA.
Genetic variation and recombination of RdRp and HSP 70h genes of Citrus tristeza virus isolates from orange trees showing symptoms of citrus sudden death disease.
Impact of Two Reoviruses and Their Coinfection on the Rice RNAi System and vsiRNA Production.
Production and characterization of monospecific and bispecific antibodies against dengue virus NS1 protein.
The First Identified Citrus tristeza virus Isolate of Turkey Contains a Mixture of Mild and Severe Strains.
Virion-associated transcriptase activity of influenza recombinant and mutant strains.
Colitis, Ulcerative
Human antigen R (HuR) and Cold inducible RNA-binding protein (CIRP) influence intestinal mucosal barrier function in ulcerative colitis by competitive regulation on Claudin1.
Identification of beta-subunit of bacterial RNA-polymerase--a non-species-specific bacterial protein--as target of antibodies in primary biliary cirrhosis.
Colonic Neoplasms
Blocking the IGF2BP1-promoted glucose metabolism of colon cancer cells via direct de-stabilizing mRNA of the LDHA enhances anticancer effects.
CBX8 acts as an independent RNA-binding protein to regulate the maturation of miR-378a-3p in colon cancer cells.
Editorial retraction. Down-regulation of human telomerase reverse transcriptase through anti-c-myc siRNA in human colon cancer Colo 320 cells.
Expression of oncofetal RNA-binding protein CRD-BP/IMP1 predicts clinical outcome in colon cancer.
Expression of RNA-binding Motif Protein 3 (
Identification of specific modules and significant genes associated with colon cancer by weighted gene co?expression network analysis.
LIN28B promotes the progression of colon cancer by increasing B-cell lymphoma 2 expression.
LINC00538 promotes the progression of colon cancer through inhibiting NKD2 expression.
Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1.
RBMS1 Suppresses Colon Cancer Metastasis through Targeted Stabilization of Its mRNA Regulon.
RNA-Binding Protein Quaking, a Critical Regulator of Colon Epithelial Differentiation and a Suppressor of Colon Cancer.
The RNA-Binding Protein Musashi1: A Major Player in Intestinal Epithelium Renewal and Colon Cancer Development.
The RNA-binding protein RBM3 is required for cell proliferation and protects against serum deprivation-induced cell death.
Colorado Tick Fever
Complete nucleotide sequences of genome segments 1 and 3 of Rosellinia anti-rot virus in the family Reoviridae.
Colorectal Neoplasms
Clinical Significance of Methylation and Reduced Expression of the Quaking Gene in Colorectal Cancer.
Frameshift Mutation of FXR1 Encoding a RNA-Binding Protein in Gastric and Colorectal Cancers with Microsatellite Instability.
High RBM3 expression in prostate cancer independently predicts a reduced risk of biochemical recurrence and disease progression.
HNRNPLL stabilizes mRNA for DNA replication proteins and promotes cell cycle progression in colorectal cancer cells.
HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation.
HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis.
Increased IGF2BP3 expression promotes the aggressive phenotypes of colorectal cancer cells in vitro and vivo.
Loss of RNA-Binding Protein RBMS1 Promotes a Metastatic Transcriptional Program in Colorectal Cancer.
MicroRNA-24 regulates the growth and chemosensitivity of the human colorectal cancer cells by targeting RNA-binding protein DND1.
MicroRNAs, long noncoding RNAs, and circular RNAs: potential tumor biomarkers and targets for colorectal cancer.
miR-181b functions as an oncomiR in colorectal cancer by targeting PDCD4.
RNA-binding protein CELF1 enhances cell migration, invasion, and chemoresistance by targeting ETS2 in colorectal cancer.
RNA-binding protein IMP3 is a novel regulator of MEK1/ERK signaling pathway in the progression of colorectal Cancer through the stabilization of MEKK1 mRNA.
RNA-Binding Protein Polymorphisms as Novel Biomarkers to Predict Outcomes of Metastatic Colorectal Cancer: A Meta-analysis from TRIBE, FIRE-3, and MAVERICC.
RNA-binding protein RALY reprogrammes mitochondrial metabolism via mediating miRNA processing in colorectal cancer.
RNA-binding protein RBM38 inhibits colorectal cancer progression by partly and competitively binding to PTEN 3'UTR with miR-92a-3p.
RNAi-mediated HuR depletion leads to the inhibition of muscle cell differentiation.
The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma.
The RNA-Binding Protein ESRP1 Modulates the Expression of RAC1b in Colorectal Cancer Cells.
The RNA-binding protein ESRP1 promotes human colorectal cancer progression.
The RNA-Binding Protein HuR Confers Oxaliplatin Resistance of Colorectal Cancer By Upregulating CDC6.
Common Cold
Biochemical characterization of rhinovirus RNA-dependent RNA polymerase.
Combined in silico and in vitro approaches identified the antipsychotic drug lurasidone and the antiviral drug elbasvir as SARS-CoV2 and HCoV-OC43 inhibitors.
The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus: a dual function target for common cold antiviral therapy.
Communicable Diseases
Approved Antiviral Drugs over the Past 50 Years.
Epidemiologic applications of novel molecular methods to detect and differentiate small round structured viruses (Norwalk-like viruses).
Lost in transcription--inhibition of RNA polymerase.
Messenger RNA Vaccines: Beckoning of a New Era in Cancer Immunotherapy.
Q63, a novel DENV2 RdRp non-nucleoside inhibitor, inhibited DENV2 replication and infection.
Serological Differences after Acute Zika Virus Infections between Children and Adults: Implication for Use of a Serological Test.
Communicable Diseases, Emerging
Expression of vector-based small interfering RNA against West Nile virus effectively inhibits virus replication.
Confusion
Tobacco mosaic virus replicase and replicative structures.
Congenital Abnormalities
GroEL is involved in activation of Escherichia coli RNA polymerase devoid of the omega subunit in vivo.
Connective Tissue Diseases
The long-term outcome of interstitial lung disease with anti-aminoacyl-tRNA synthetase antibodies.
Coronavirus Infections
A25?Phylogenetic analysis of the nucleocapsid and RNA-dependent RNA polymerase fragments of the first imported case of middle east respiratory syndrome coronavirus (MERS-CoV) infection in the Philippines from Saudi Arabia, February 2015.
Alpha and lineage C betaCoV infections in Italian bats.
Coronavirus infectious bronchitis virus non-structural proteins 8 and 12 form stable complex independent of the non-translated regions of viral RNA and other viral proteins.
Current approaches for target-specific drug discovery using natural compounds against SARS-CoV-2 infection.
Lycorine, a non-nucleoside RNA dependent RNA polymerase inhibitor, as potential treatment for emerging coronavirus infections.
Middle East Respiratory Syndrome Coronavirus 4a Protein Is a Double-Stranded RNA-Binding Protein That Suppresses PACT-Induced Activation of RIG-I and MDA5 in the Innate Antiviral Response.
NeoCoV Is Closer to MERS-CoV than SARS-CoV.
On the molecular structure of Remdesivir for the treatment of Covid-19.
Pharmacological Therapeutics Targeting RNA-Dependent RNA Polymerase, Proteinase and Spike Protein: From Mechanistic Studies to Clinical Trials for COVID-19.
RNA-dependent RNA polymerase of SARS-CoV-2 as a therapeutic target.
SARS-CoV-2 RdRp Inhibitors Selected from a Cell-Based SARS-CoV-2 RdRp Activity Assay System.
The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus.
The potential chemical structure of anti-SARS-CoV-2 RNA-dependent RNA polymerase.
Whole Genome Analysis and Targeted Drug Discovery Using Computational Methods and High Throughput Screening Tools for Emerged Novel Coronavirus (2019-nCoV).
Cough
A randomized and comparative study to assess safety and efficacy of supplemental treatment of a herbal formulation - Aayudh Advance comprising essential oils in patients with corona virus 2019 (COVID-19).
SARS-CoV-2 Infection and Antibody Response in a Symptomatic Cat from Italy with Intestinal B-Cell Lymphoma.
COVID-19
"Bucket brigade" using lysine residues in RNA-dependent RNA polymerase of SARS-CoV-2.
A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase.
A computational analysis of molecular evolution for virulence genes of zoonotic novel coronavirus (COVID-19).
A multiple peptides vaccine against COVID-19 designed from the nucleocapsid phosphoprotein (N) and Spike Glycoprotein (S) via the immunoinformatics approach.
A nanoscale genosensor for early detection of COVID-19 by voltammetric determination of RNA-dependent RNA polymerase (RdRP) sequence of SARS-CoV-2 virus.
Acetylcysteine for the Treatment of Suspected Remdesivir-Associated Acute Liver Failure in COVID-19: A Case Series.
An in silico approach for identification of novel inhibitors as potential therapeutics targeting COVID-19 main protease.
An in silico approach to target RNA-dependent RNA polymerase of COVID-19 with naturally occurring phytochemicals.
Anisotine and amarogentin as promising inhibitory candidates against SARS-CoV-2 proteins: a computational investigation.
Anti-HCV, nucleotide inhibitors, repurposing against COVID-19.
Antiviral effects of probiotic metabolites on COVID-19.
Are clarithromycin, azithromycin and their analogues effective in the treatment of COVID19?
Association Between ABO and Rh Blood Groups and SARS-CoV-2 Infection or Severe COVID-19 Illness : A Population-Based Cohort Study.
AVIFAVIR for Treatment of Patients With Moderate Coronavirus Disease 2019 (COVID-19): Interim Results of a Phase II/III Multicenter Randomized Clinical Trial.
Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase.
Binding mechanism and structural insights into the identified protein target of COVID-19 and importin-? with in-vitro effective drug ivermectin.
C60 fullerene against SARS-CoV-2 coronavirus: an in silico insight.
Can mesenchymal stem cell therapy be the interim management of COVID-19?
Chemical composition and pharmacological mechanism of shenfu decoction in the treatment of novel coronavirus pneumonia (COVID-19).
Clinical Efficacy of Remdesivir and Favipiravir in the Treatment of Covid-19 Patients: Scenario So Far.
Clinical profile, viral load, management and outcome of neonates born to COVID 19 positive mothers: a tertiary care centre experience from India.
Combination of QSAR, molecular docking, molecular dynamic simulation and MM-PBSA: analogues of lopinavir and favipiravir as potential drug candidates against COVID-19.
Combining SARS-CoV-2 Proofreading Exonuclease and RNA-Dependent RNA Polymerase Inhibitors as a Strategy to Combat COVID-19: A High-Throughput in silico Screening.
Comparative Evaluation of Tears and Nasopharyngeal Swab for SARS-CoV-2 in COVID-19 Dedicated Intensive Care Unit Patients.
Comprehensive Virtual Screening of the Antiviral Potentialities of Marine Polycyclic Guanidine Alkaloids against SARS-CoV-2 (COVID-19).
Computational investigation for identification of potential phytochemicals and antiviral drugs as potential inhibitors for RNA-dependent RNA polymerase of COVID-19.
Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase.
Current targets and drug candidates for prevention and treatment of SARS-CoV-2 (COVID-19) infection.
Cyanorona-20: The first potent anti-SARS-CoV-2 agent.
Delayed Development of Coronary Artery Dilitation in Suspected Severe Acute Respiratory Syndrome Coronavirus 2 Multisystem Inflammatory Syndrome: More Research Needed.
Denovo designing, retro-combinatorial synthesis, and molecular dynamics analysis identify novel antiviral VTRM1.1 against RNA-dependent RNA polymerase of SARS CoV2 virus.
Design and in-silico screening of Peptide Nucleic Acid (PNA) inspired novel pronucleotide scaffolds targeting COVID-19.
Detection and quantification of SARS-CoV-2 by droplet digital PCR in real-time PCR negative nasopharyngeal swabs from suspected COVID-19 patients.
Determination of human COVID-19 total antibodies in serum using a time-resolved fluorescence immunoassay.
Development of a Smartphone-Based Nanozyme-Linked Immunosorbent Assay for Quantitative Detection of SARS-CoV-2 Nucleocapsid Phosphoprotein in Blood.
Development of remdesivir repositioning as a nucleotide analog against COVID-19 RNA dependent RNA polymerase.
Different selection dynamics of S and RdRp between SARS-CoV-2 genomes with and without the dominant mutations.
Discovering Potential RNA Dependent RNA Polymerase Inhibitors as Prospective Drugs Against COVID-19: An in silico Approach.
Discovery of (E)-N-(4-cyanobenzylidene)- 6-fluoro- 3-hydroxypyrazine-2 -carboxamide (cyanorona-20): the first potent and specific anti-COVID-19 drug.
Discovery of potential multi-target-directed ligands by targeting host-specific SARS-CoV-2 structurally conserved main protease.
Dynamic properties of SARS-CoV and SARS-CoV-2 RNA-dependent RNA polymerases studied by molecular dynamics simulations.
Efficacy and safety of favipiravir, an oral RNA-dependent RNA polymerase inhibitor, in mild-to-moderate COVID-19: A randomized, comparative, open-label, multicenter, phase 3 clinical trial.
Efficacy and safety of remdesivir in COVID-19 caused by SARS-CoV-2: a systematic review and meta-analysis.
Elucidating the drug repurposing spectra of COVID-19 with its analogues SARS and MERS.
Emergence of Drift Variants That May Affect COVID-19 Vaccine Development and Antibody Treatment.
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant.
Enisamium is an inhibitor of the SARS-CoV-2 RNA polymerase and shows improvement of recovery in COVID-19 patients in an interim analysis of a clinical trial.
Entropy-driven amplified electrochemiluminescence biosensor for RdRp gene of SARS-CoV-2 detection with self-assembled DNA tetrahedron scaffolds.
Establishing diagnostic algorithms for SARS-CoV-2 nucleic acid testing in clinical practice.
Evaluation of potential anti-RNA-dependent RNA polymerase (RdRP) drugs against the newly emerged model of COVID-19 RdRP using computational methods.
Evaluation of RdRp & ORF-1b-nsp14-based real-time RT-PCR assays for confirmation of SARS-CoV-2 infection: An observational study.
Evaluation on the use of Nanopore sequencing for direct characterization of coronaviruses from respiratory specimens, and a study on emerging missense mutations in partial RdRP gene of SARS-CoV-2.
Evidence of the presence of SARS-CoV-2 virus in atmospheric air and surfaces of a dedicated COVID hospital.
Existing antiviral options against SARS-CoV-2 replication in COVID-19 patients.
Exploiting Existing Molecular Scaffolds for Long-Term COVID Treatment.
Exploring the SARS-CoV-2 main protease (Mpro) and RdRp targets by updating current structure-based drug design utilizing co-crystals to combat COVID-19.
Expression and purification of tag-free SARS-CoV-2 RNA-dependent RNA polymerase in Escherichia coli.
Facilitating SARS CoV-2 RNA-Dependent RNA polymerase (RdRp) drug discovery by the aid of HCV NS5B palm subdomain binders: In silico approaches and benchmarking.
Favipiravir strikes the SARS-CoV-2 at its Achilles heel, the RNA polymerase.
Favipiravir versus other antiviral or standard of care for COVID-19 treatment: a rapid systematic review and meta-analysis.
Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets.
Fighting COVID-19: A quick review of diagnoses, therapies, and vaccines.
Genetic Risk Factors for the Development of COVID-19 Coronavirus Infection.
Health Surveillance and Response to SARS-CoV-2 Mass Testing in Health Workers of a Large Italian Hospital in Verona, Veneto.
High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from the Covid-19 severe acute respiratory syndrome coronavirus 2.
HISNAPI: a bioinformatic tool for dynamic hot spot analysis in nucleic acid-protein interface with a case study.
Hordatines as a Potential Inhibitor of COVID-19 Main Protease and RNA Polymerase: An In-Silico Approach.
Identification and characterization of mutations in the SARS-CoV-2 RNA-dependent RNA polymerase as a promising antiviral therapeutic target.
Identification of a novel dual-target scaffold for 3CLpro and RdRp proteins of SARS-CoV-2 using 3D-similarity search, molecular docking, molecular dynamics and ADMET evaluation.
Identification of nsp1 gene as the target of SARS-CoV-2 real-time RT-PCR using nanopore whole-genome sequencing.
Identification of Potential Key Agents for Targeting RNA-Dependent RNA Polymerase of SARS-CoV-2 by Integrated Analysis and Virtual Drug Screening.
Implications of SARS-CoV-2 genetic diversity and mutations on pathogenicity of the COVID-19 and biomedical interventions.
Improved sensitivity using a dual target, E and RdRp assay for the diagnosis of SARS-CoV-2 infection: Experience at a large NHS Foundation Trust in the UK.
In silico identification of promising inhibitor against RNA-dependent RNA polymerase target of SARS-CoV-2.
In silico screening of hundred phytocompounds of ten medicinal plants as potential inhibitors of nucleocapsid phosphoprotein of COVID-19: an approach to prevent virus assembly.
In silico studies on therapeutic agents for COVID-19: Drug repurposing approach.
Interface-based design of the favipiravir-binding site in SARS-CoV-2 RNA-dependent RNA polymerase reveals mutations conferring resistance to chain termination.
Interpret with caution: An evaluation of the commercial AusDiagnostics versus in-house developed assays for the detection of SARS-CoV-2 virus.
Investigating the Internalization and COVID-19 Antiviral Computational Analysis of Optimized Nanoscale Zinc Oxide.
Is there a correlation between viral load and olfactory & taste dysfunction in COVID-19 patients?
Is there a link between lung parenchyma lesions , BMI , CRP , D-dimer and acute pulmonary embolism in patients infected with COVID-19 ?
Letter to the editor on "Efficacy and safety of favipiravir, an oral RNA-dependent RNA polymerase inhibitor, in mild-to-moderate COVID-19: A randomized, comparative, open-label, multicenter, phase 3 clinical trial" by Udwadia et al.
Lung transcriptome of a COVID-19 patient and systems biology predictions suggest impaired surfactant production which may be druggable by surfactant therapy.
Lycorine, a non-nucleoside RNA dependent RNA polymerase inhibitor, as potential treatment for emerging coronavirus infections.
Metabolomic profiling of three Araucaria species, and their possible potential role against COVID-19.
Molecular detection of SARS-CoV-2 from indoor air samples in environmental monitoring needs adequate temporal coverage and infectivity assessment.
Molecular docking and dynamics studies of Nicotinamide Riboside as a potential multi-target nutraceutical against SARS-CoV-2 entry, replication, and transcription: A new insight.
Molecular dynamics simulation, 3D-pharmacophore and scaffold hopping analysis in the design of multi-target drugs to inhibit potential targets of COVID-19.
Molecular modelling of the antiviral action of Resveratrol derivatives against the activity of two novel SARS CoV-2 and 2019-nCoV receptors.
Molecular targets for COVID-19 drug development: Enlightening Nigerians about the pandemic and future treatment.
Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template.
N-acetylcysteine (NAC) and Hydrogen Sulfide (H2S) in Coronavirus Disease 2019 (COVID-19).
New-Onset IgG Autoantibodies in Hospitalized Patients with COVID-19.
Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA.
Novel Development of Predictive Feature Fingerprints to Identify Chemistry-Based Features for the Effective Drug Design of SARS-CoV-2 Target Antagonists and Inhibitors Using Machine Learning.
Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase, a Key Drug Target for COVID-19.
On the molecular structure of Remdesivir for the treatment of Covid-19.
One-Step Quantitative RT-PCR Assay with Armored RNA Controls for Detection of SARS-CoV-2.
Peptides: Prospects for Use in the Treatment of COVID-19.
Persistent Smell Loss Following Undetectable SARS-CoV-2.
Pharmacological Therapeutics Targeting RNA-Dependent RNA Polymerase, Proteinase and Spike Protein: From Mechanistic Studies to Clinical Trials for COVID-19.
Plant-derived natural polyphenols as potential antiviral drugs against SARS-CoV-2 via RNA-dependent RNA polymerase (RdRp) inhibition: an in-silico analysis.
Poliovirus Vaccination Induces a Humoral Immune Response That Cross Reacts With SARS-CoV-2.
Potential Candidates against COVID-19 Targeting RNA-Dependent RNA Polymerase: A Comprehensive Review.
Potential RNA-dependent RNA polymerase inhibitors as prospective therapeutics against SARS-CoV-2.
Potential therapeutic targets for combating SARS-CoV-2: Drug repurposing, clinical trials and recent advancements.
Practical Remdesivir Synthesis through One-Pot Organocatalyzed Asymmetric (S)-P-Phosphoramidation.
Prediction of potential inhibitors for RNA-dependent RNA polymerase of SARS-CoV-2 using comprehensive drug repurposing and molecular docking approach.
Quantitative Structure-Activity Relationship Machine Learning Models and their Applications for Identifying Viral 3CLpro- and RdRp-Targeting Compounds as Potential Therapeutics for COVID-19 and Related Viral Infections.
Quinolines-Based SARS-CoV-2 3CLpro and RdRp Inhibitors and Spike-RBD-ACE2 Inhibitor for Drug-Repurposing Against COVID-19: An in silico Analysis.
Raltegravir, Indinavir, Tipranavir, Dolutegravir, and Etravirine against main protease and RNA-dependent RNA polymerase of SARS-CoV-2: A molecular docking and drug repurposing approach.
Rapid Diagnosis of Coronavirus by RNA-Directed RNA Transcription Using an Engineered RNA-based Platform.
Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis.
Recent advances in the discovery of potent RNA-dependent RNA-polymerase (RdRp) inhibitors targeting viruses.
Remdesivir failure with SARS-CoV-2 RNA-dependent RNA-polymerase mutation in a B-cell immunodeficient patient with protracted Covid-19.
Remdesivir for 5 or 10 Days in Patients with Severe Covid-19.
Remdesivir Is Effective in Combating COVID-19 because It Is a Better Substrate than ATP for the Viral RNA-Dependent RNA Polymerase.
Remdesivir Strongly Binds to Both RNA-Dependent RNA Polymerase and Main Protease of SARS-CoV-2: Evidence from Molecular Simulations.
Remdesivir Treatment for COVID 19 in Pregnant Patients with Moderate to Severe Symptoms: Serial Case Report.
Repositioning HIV protease inhibitors and nucleos(t)ide RNA polymerase inhibitors for the treatment of SARS-CoV-2 infection and COVID-19.
Repurposing FDA-approved drugs to fight COVID-19 using in silico methods: Targeting SARS-CoV-2 RdRp enzyme and host cell receptors (ACE2, CD147) through virtual screening and molecular dynamic simulations.
Repurposing FDA-approved phytomedicines, natural products, antivirals and cell protectives against SARS-CoV-2 (COVID-19) RNA-dependent RNA polymerase.
Response to the comments received on article "Efficacy and safety of favipiravir, an oral RNA-dependent RNA polymerase inhibitor, in mild-to-moderate COVID-19: A randomized, comparative, open-label, multicenter, phase 3 clinical trial" by Udwadia et al.
Revealing the Inhibition Mechanism of RNA-Dependent RNA Polymerase (RdRp) of SARS-CoV-2 by Remdesivir and Nucleotide Analogues: A Molecular Dynamics Simulation Study.
RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic.
RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery.
RNA-dependent RNA polymerase, RdRP, a promising therapeutic target for cancer and potentially COVID-19.
RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19.
RT-qPCR Diagnostics: The "Drosten" SARS-CoV-2 Assay Paradigm.
SARS-CoV-2 and miRNA-like inhibition power.
SARS-CoV-2 Nonstructural Protein 1 Inhibits the Interferon Response by Causing Depletion of Key Host Signaling Factors.
SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism.
SARS-CoV-2 NSP12 Protein Is Not an Interferon-? Antagonist.
SARS-CoV-2 orf1b Gene Sequence in the NTNG1 Gene on Human Chromosome 1.
SARS-CoV-2 RdRp Inhibitors Selected from a Cell-Based SARS-CoV-2 RdRp Activity Assay System.
SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective.
SARS-CoV-2 RNA-dependent RNA polymerase as a therapeutic target for COVID-19.
SARS-CoV-2 Treatment Approaches: Numerous Options, No Certainty for a Versatile Virus.
SARS-CoV-2: Origin, Evolution, and Targeting Inhibition.
Screening and Molecular Modeling Evaluation of Food Peptides to Inhibit Key Targets of COVID-19 Virus.
Screening of drug databank against WT and mutant main protease of SARS-CoV-2: Towards finding potential compound for repurposing against COVID-19.
Screening of potent drug inhibitors against SARS-CoV-2 RNA polymerase: an in silico approach.
Second Episode of COVID-19 in Health Professionals: Report of Two Cases.
Severe acute respiratory illness surveillance for coronavirus disease 2019, India, 2020.
Sewage surveillance for the presence of SARS-CoV-2 genome as a useful wastewater based epidemiology (WBE) tracking tool in India.
Sinus Bradycardia in a Pediatric Patient Treated With Remdesivir for Acute Coronavirus Disease 2019: A Case Report and a Review of the Literature.
Spike protein D614G and RdRp P323L: the SARS-CoV-2 mutations associated with severity of COVID-19.
Status of Health-care Workers in Relation to COVID-19 Infection: A Retrospective Study in a Level 4 COVID Hospital in Eastern India.
Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.
Structural Insights into the Binding Modes of Viral RNA-Dependent RNA Polymerases Using a Function-Site Interaction Fingerprint Method for RNA Virus Drug Discovery.
Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
Systematic duplex ultrasound screening in conventional units for COVID-19 patients with follow-up of 5 days.
Targeting SARS-CoV-2 RNA-dependent RNA polymerase: An in silico drug repurposing for COVID-19.
Targeting Viral RNA-Dependent RNA Polymerases as an Antiviral Therapy.
The anti-HCV, Sofosbuvir, versus the anti-EBOV Remdesivir against SARS-CoV-2 RNA dependent RNA polymerase in silico.
The Binding of Remdesivir to SARS-CoV-2 RNA-Dependent RNA Polymerase May Pave The Way Towards the Design of Potential Drugs for COVID-19 Treatment.
The Computational Intervention of Macrolide Antibiotics in the Treatment of COVID-19.
The Current Recommended Drugs and Strategies for the Treatment of Coronavirus Disease (COVID-19).
The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2.
The molecular assessment of SARS-CoV-2 Nucleocapsid Phosphoprotein variants among Indian isolates.
The Promising Enzymes for Inhibitors Development against COVID-19.
Therapeutic management of COVID-19 patients: Clinical manifestation and limitations.
Time Length of Negativization and Cycle Threshold Values in 182 Healthcare Workers with Covid-19 in Milan, Italy: An Observational Cohort Study.
TMPRSS2 and RNA-Dependent RNA Polymerase Are Effective Targets of Therapeutic Intervention for Treatment of COVID-19 Caused by SARS-CoV-2 Variants (B.1.1.7 and B.1.351).
Treatment options for COVID-19: The reality and challenges.
Variable effects of underlying diseases on the prognosis of patients with COVID-19.
Viral Load Difference between Symptomatic and Asymptomatic COVID-19 Patients: Systematic Review and Meta-Analysis.
[Comparison of Real Time PCR Cycle Threshold Values in Symptomatic and Asymptomatic COVID-19 Patients].
[Promising and potential drugs for the treatment of COVID-19].
[The use of viral RNA polymerase inhibitors in combination with a fusion inhibitor in the treatment of patients with COVID-19: hypothesis].
Cowpox
Fine structure mapping and phenotypic analysis of five temperature-sensitive mutations in the second largest subunit of vaccinia virus DNA-dependent RNA polymerase.
Post-transcription cleavage generates the 3' end of F17R transcripts in vaccinia virus.
Crohn Disease
Identification of beta-subunit of bacterial RNA-polymerase--a non-species-specific bacterial protein--as target of antibodies in primary biliary cirrhosis.
Cryptorchidism
Association between RNA-binding protein Ptbp2 and germ cell injury in an experimentally-induced unilateral cryptorchidism murine model.
Downregulation of cold-inducible RNA-binding protein activates mitogen-activated protein kinases and impairs spermatogenic function in mouse testes.
Effects of cold-inducible RNA-binding protein on the proliferation and apoptosis of spermatogenic cells invitro following heat stress.
Overexpression of CIRP may reduce testicular damage induced by cryptorchidism.
Cystic Fibrosis
Discovery of Ubonodin, an Antimicrobial Lasso Peptide Active against Members of the Burkholderia cepacia Complex.
Secretory low-molecular-weight phospholipases A2 and their specific receptor in bile ducts of patients with intrahepatic calculi: factors of chronic proliferative cholangitis.
Cysts
Arabidopsis small RNAs and their targets during cyst nematode parasitism.
Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow.
Levels of RNA polymerase activities during growth, encystment and germination ofPhysarum polycephalum.
Cytomegalovirus Infections
Approved Antiviral Drugs over the Past 50 Years.
Detection of active cytomegalovirus infection in inflammatory aortic aneurysms with RNA polymerase chain reaction.
Regarding "Detection of active cytomegalovirus infection in inflammatory aortic aneurysms with RNA polymerase chain reaction".
Cytomegalovirus Retinitis
[Cytomegalovirus retinitis in pediatric patients with AIDS receiving highly active antiretrovirus therapy]
Decompression Sickness
A comprehensive alanine scanning mutagenesis of the Escherichia coli transcriptional activator SoxS: identifying amino acids important for DNA binding and transcription activation.
Involvement of the global Crp regulator in cyclic AMP-dependent utilization of aromatic amino acids by Pseudomonas putida.
Maximal transcriptional activation by the IHF protein of Escherichia coli depends on optimal DNA bending by the activator.
Mesoscale modeling of multi-protein-DNA assemblies: the role of the catabolic activator protein in Lac-repressor-mediated looping.
Participation of IHF and a distant UP element in the stimulation of the phage lambda PL promoter.
Transcriptional activation of promoters of the superoxide and multiple antibiotic resistance regulons by Rob, a binding protein of the Escherichia coli origin of chromosomal replication.
Dehydration
Conformational coupling, bridge helix dynamics and active site dehydration in catalysis by RNA polymerase.
Incidence and predictive factors of transaminase elevation in patients consulting for dengue fever in Cayenne Hospital, French Guiana.
Dementia
ALS/FTLD-Linked Mutations in FUS Glycine Residues Cause Accelerated Gelation and Reduced Interactions with Wild-Type FUS.
An Amyloid-Like Pathological Conformation of TDP-43 Is Stabilized by Hypercooperative Hydrogen Bonds.
An optimized InCell Western screening technique identifies hexachlorophene as a novel potent TDP43 targeting drug.
Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein.
Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.
Myo-granules Connect Physiology and Pathophysiology.
Neurotoxic effects of TDP-43 overexpression in C. elegans.
Restoration of motor defects caused by loss of Drosophila TDP-43 by expression of the voltage-gated calcium channel, Cacophony, in central neurons.
S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD.
Structural basis for RNA recognition by the N-terminal tandem RRM domains of human RBM45.
The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia.
Demyelinating Diseases
miRNA-Coordinated Schizophrenia Risk Network Cross-Talk With Cardiovascular Repair and Opposed Gliomagenesis.
Transgenic Expression of the 3D Polymerase Inhibits Theiler's Virus Infection and Demyelination.
Dengue
A 5' RNA element promotes dengue virus RNA synthesis on a circular genome.
A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening.
A Critical Role for Perivascular Cells in Amplifying Vascular Leakage Induced by Dengue Virus Nonstructural Protein 1.
A crystal structure of the Dengue virus NS5 polymerase delineates inter-domain amino acids residues that enhance its thermostability and de novo initiation activities.
A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication.
A fluorescence-based alkaline phosphatase-coupled polymerase assay for identification of inhibitors of dengue virus RNA-dependent RNA polymerase.
A multi-step strategy to obtain crystals of the dengue virus RNA-dependent RNA polymerase that diffract to high resolution.
A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle.
A Review on the Progress and Prospects of Dengue Drug Discovery Targeting NS5 RNA- Dependent RNA Polymerase.
A single amino acid in nonstructural protein NS4B confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis.
A small region of the dengue virus-encoded RNA-dependent RNA polymerase, NS5, confers interaction with both the nuclear transport receptor importin-beta and the viral helicase, NS3.
A structural view of the RNA-dependent RNA polymerases from the Flavivirus genus.
A T164S mutation in the dengue virus NS1 protein is associated with greater disease severity in mice.
Alkylated flavanones from the bark of Cryptocarya chartacea as dengue virus NS5 polymerase inhibitors.
An antigen capture enzyme-linked immunosorbent assay reveals high levels of the dengue virus protein NS1 in the sera of infected patients.
An In-Silico Investigation of Phytochemicals as Antiviral Agents against Dengue Fever.
An N-Terminal Amphipathic Helix in Dengue Virus Nonstructural Protein 4A Mediates Oligomerization and Is Essential for Replication.
Analysis of the virus propagation profile of 14 dengue virus isolates in Aedes albopictus C6/36 cells.
Anti-dengue virus nonstructural protein 1 antibodies contribute to platelet phagocytosis by macrophages.
Anti-dengue virus nonstructural protein 1 antibodies recognize protein disulfide isomerase on platelets and inhibit platelet aggregation.
Antibodies against nonstructural protein 1 protect mice from dengue virus-induced mast cell activation.
Antibodies from dengue patient sera cross-react with endothelial cells and induce damage.
Application of antibodies against nonstructural protein 2B of dengue serotype 2 virus induced by DNA immunisation or recombinant protein NS 2B immunisation in BALB/c mice.
Approach to non-invasive sampling in dengue diagnostics: exploring virus and NS1 antigen detection in saliva and urine of travelers with dengue.
Apropos "Evaluation of dengue nonstructural protein 1 antigen strip for the rapid diagnosis of patients with dengue infection"
Association between NS3 and NS5 proteins of dengue virus type 2 in the putative RNA replicase is linked to differential phosphorylation of NS5.
Betulinic acid, the first lupane-type triterpenoid isolated from both a Phomopsis sp. and its host plant Diospyros carbonaria Benoist.
Beyond Members of the Flaviviridae Family, Sofosbuvir Also Inhibits Chikungunya Virus Replication.
Biflavonoids of Dacrydium balansae with Potent Inhibitory Activity on Dengue 2 NS5 Polymerase.
Biochemical characterization of the inhibition of the dengue virus RNA polymerase by beta-d-2'-ethynyl-7-deaza-adenosine triphosphate.
Chagas Disease in Southern Coastal Ecuador: Coinfections with Arboviruses and a Comparison of Serological Assays for Chagas Disease Diagnosis.
Characterisation of inter- and intra-molecular interactions of the dengue virus RNA dependent RNA polymerase as potential drug targets.
Characterization of dengue virus NS1 stably expressed in 293T cell lines.
Characterization of soluble RNA-dependent RNA polymerase from dengue virus serotype 2: The polyhistidine tag compromises the polymerase activity.
Characterization of the elongation complex of dengue virus RNA polymerase: assembly, kinetics of nucleotide incorporation, and fidelity.
Chemical constituents of Anacolosa pervilleana and their antiviral activities.
Clinical and Epidemiological Characterization of the First Recognized Outbreak of Dengue Virus-Type 2 in Mozambique, 2014.
Clinical and Laboratory Diagnosis of Dengue Virus Infection.
Clinical and Laboratory Profile of Zika and Dengue Infected Patients: Lessons Learned From the Co-circulation of Dengue, Zika and Chikungunya in Brazil.
Clinical diagnosis of early dengue infection by novel one-step multiplex real-time RT-PCR targeting NS1 gene.
Clinical features and outcomes of neonatal dengue at the Children's Hospital 1, Ho Chi Minh, Vietnam.
Clinical features and pitfalls in the laboratory diagnosis of dengue in travellers.
Coarse-Grained Molecular Modeling of the Solution Structure Ensemble of Dengue Virus Nonstructural Protein 5 with Small-Angle X-ray Scattering Intensity.
Coinfection of chikungunya and dengue viruses: A serological study from North Western region of Punjab, India.
Combination of Nonstructural Protein 1-Based Enzyme-Linked Immunosorbent Assays Can Detect and Distinguish Various Dengue Virus and Zika Virus Infections.
Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerases.
Comparison of capture immunoglobulin M (IgM) and IgG enzyme-linked immunosorbent assay (ELISA) and nonstructural protein NS1 serotype-specific IgG ELISA for differentiation of primary and secondary dengue virus infections.
Comparison of two commercially available dengue virus (DENV) NS1 capture enzyme-linked immunosorbent assays using a single clinical sample for diagnosis of acute DENV infection.
Comprehensive mapping of immunodominant and conserved serotype- and group-specific B-cell epitopes of nonstructural protein 1 from dengue virus type 1.
Conformational flexibility of the dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor.
Construction of recombinant Kluyveromyces marxianus UFV-3 to express dengue virus type 1 nonstructural protein 1 (NS1).
Correlation between Serum Levels of Anti-Endothelial Cell Autoantigen and Anti-Dengue Virus Nonstructural Protein 1 Antibodies in Dengue Patients.
Critical role of Dengue Virus NS1 protein in viral replication.
CRM1-dependent nuclear export of dengue virus type 2 NS5.
CRM1-mediated nuclear export of dengue virus RNA polymerase NS5 modulates interleukin-8 induction and virus production.
Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution.
Cyclic Dinucleotide-Adjuvanted Dengue Virus Nonstructural Protein 1 Induces Protective Antibody and T Cell Responses.
De novo synthesis of negative-strand RNA by Dengue virus RNA-dependent RNA polymerase in vitro: nucleotide, primer, and template parameters.
De novo synthesis of RNA by the dengue virus RNA-dependent RNA polymerase exhibits temperature dependence at the initiation but not elongation phase.
Deadly intracranial bleed in patients with dengue fever: A series of nine patients and review of literature.
Defining the Utility of a Commercial NS1 Antigen Capture Kit as a Dengue Virus (DENV) Diagnostic Tool.
Deletion analysis of dengue virus type 4 nonstructural protein NS2B: identification of a domain required for NS2B-NS3 protease activity.
Deletion of the C-terminal region of dengue virus nonstructural protein 1 (NS1) abolishes anti-NS1-mediated platelet dysfunction and bleeding tendency.
Dengue epidemics in two distinct periods reveal distinct epidemiological, laboratorial and clinical aspects in a same scenario: analysis of the 2010 and 2013 epidemics in Mato Grosso do Sul, Brazil.
Dengue nonstructural protein 1 antigen in the urine as a rapid and convenient diagnostic test during the febrile stage in patients with dengue infection.
Dengue Nonstructural Protein 1 Maintains Autophagy through Retarding Caspase-Mediated Cleavage of Beclin-1.
Dengue NS2A Protein Orchestrates Virus Assembly.
Dengue viremia in blood donors in Northern India: Challenges of emerging dengue outbreaks to blood transfusion safety.
Dengue virus non-structural protein 1: a pathogenic factor, therapeutic target, and vaccine candidate.
Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage.
Dengue Virus Nonstructural Protein 1 Induces Vascular Leakage through Macrophage Migration Inhibitory Factor and Autophagy.
Dengue virus nonstructural protein 1 is expressed in a glycosyl-phosphatidylinositol-linked form that is capable of signal transduction.
Dengue Virus Nonstructural Protein 1-Induced Antibodies Cross-React with Human Plasminogen and Enhance Its Activation.
Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface.
Dengue Virus Nonstructural Protein 5 Adopts Multiple Conformations in Solution.
Dengue virus nonstructural protein NS1 binds to prothrombin/thrombin and inhibits prothrombin activation.
Dengue virus nonstructural protein NS5 induces interleukin-8 transcription and secretion.
Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity.
Dengue virus RNA polymerase NS5: a potential therapeutic target?
Dengue virus serotyping based on envelope and membrane and nonstructural protein NS1 serotype-specific capture immunoglobulin M enzyme-linked immunosorbent assays.
Dengue virus structural differences that correlate with pathogenesis.
Detection of dengue virus nonstructural protein 1 (NS1) by using ELISA as a useful laboratory diagnostic method for dengue virus infection of international travelers.
Detection of Dengue Virus Nonstructural Protein 1 (NS1) in Urine Samples using ELISA as a Laboratory Diagnostic Method for Dengue Virus Infection.
Detection of dengue viruses in field caught male Aedes aegypti and Aedes albopictus (Diptera: Culicidae) in Singapore by type-specific PCR.
Determination of viremia and concentration of circulating nonstructural protein 1 in patients infected with dengue virus in Mexico.
Development of an antigen capture immunoassay based on monoclonal antibodies specific for dengue virus serotype 2 nonstructural protein 1 for early and rapid identification of dengue virus serotype 2 infections.
Development of multiplex real-time reverse transcriptase PCR assays for detecting eight medically important flaviviruses in mosquitoes.
Development of robust in vitro RNA-dependent RNA polymerase assay as a possible platform for antiviral drug testing against dengue.
Development of single-tube mutiplex RT-PCR for dengue virus typing.
Diagnosis of COVID-19 in a Dengue-Endemic Area.
Differentially expressed genes of human microvascular endothelial cells in response to anti-dengue virus NS1 antibodies by suppression subtractive hybridization.
Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase.
Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases.
Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design.
Discovery of Potent Non-nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from Fragment Screening and Structure-Guided Design.
DNA priming E and NS1 constructs--homologous proteins boosting immunization strategy to improve immune response against dengue in mice.
DNA Switch: Toehold-Mediated DNA Isothermal Amplification for Dengue Serotyping.
DNA-Modified Plasmonic Sensor for the Direct Detection of Virus Biomarkers from the Blood.
Domestic dengue infection with hemophagocytic lymphohistiocytosis successfully treated by early steroid therapy.
Dynamic Nucleolar Targeting of Dengue Virus Polymerase NS5 in Response to Extracellular pH.
Early dengue diagnosis by nonstructural protein 1 antigen detection: rapid immunochromotography versus two the enzyme-linked immunosorbent assay kits.
Effects of Short-Course Oral Corticosteroid Therapy in Early Dengue Infection in Vietnamese Patients: A Randomized, Placebo-Controlled Trial.
Electrical detection of dengue biomarker using egg yolk immunoglobulin as the biological recognition element.
Elevated dengue virus nonstructural protein 1 serum levels and altered toll-like receptor 4 expression, nitric oxide, and tumor necrosis factor alpha production in dengue hemorrhagic Fever patients.
Endothelial cell apoptosis induced by antibodies against dengue virus nonstructural protein 1 via production of nitric oxide.
Endothelial Cell Sensitization by Death Receptor Fractions of an Anti-Dengue Nonstructural Protein 1 Antibody Induced Plasma Leakage, Coagulopathy, and Mortality in Mice.
Engineered NS1 for Sensitive, Specific Zika Virus Diagnosis from Patient Serology.
Enzyme-linked immunosorbent assay specific to Dengue virus type 1 nonstructural protein NS1 reveals circulation of the antigen in the blood during the acute phase of disease in patients experiencing primary or secondary infections.
Enzyme-linked immunosorbent assay-format tissue culture infectious dose-50 test for titrating dengue virus.
Epitope Sequences in Dengue Virus NS1 Protein Identified by Monoclonal Antibodies.
Establishment and characterization of dengue virus type 2 nonstructural protein 1 specific T cell lines.
Evaluation of a commercial SD dengue virus NS1 antigen capture enzyme-linked immunosorbent assay kit for early diagnosis of dengue virus infection.
Evaluation of cardiac involvement during dengue viral infection.
Evaluation of dengue nonstructural protein 1 antigen strip for the rapid diagnosis of patients with dengue infection.
Evaluation of protective efficacy using a nonstructural protein NS1 in DNA vaccine-loaded microspheres against dengue 2 virus.
Evaluation of rapid diagnostic tests to detect dengue virus infections in Taiwan.
Evaluation of sofosbuvir activity and resistance profile against West Nile virus in vitro.
Evaluation of the diagnostic accuracy of nonstructural protein 1 Ag-based tests for dengue virus in Asian population: a meta-analysis.
Expression and purification of dengue virus NS5 polymerase and development of a high-throughput enzymatic assay for screening inhibitors of dengue polymerase.
Expression of cytokine, chemokine, and adhesion molecules during endothelial cell activation induced by antibodies against dengue virus nonstructural protein 1.
Expression of dengue virus structural proteins and nonstructural protein NS1 by a recombinant vaccinia virus.
Expression of the dengue virus type 2 NS5 protein in a CD4(+) T cell line inhibits HIV replication.
Expression, purification, and initial structural characterization of nonstructural protein 2B, an integral membrane protein of Dengue 2, in detergent micelles.
F1 Motif of Dengue Virus Polymerase NS5 Is Involved in Promoter-Dependent RNA Synthesis.
Facilitation of cell adhesion by immobilized dengue viral nonstructural protein 1 (NS1): arginine-glycine-aspartic acid structural mimicry within the dengue viral NS1 antigen.
Fatal Intracranial Hemorrhage in a Patient with Severe Dengue Fever.
Finding new medicines for flaviviral targets.
Flacourtosides A-F, phenolic glycosides isolated from Flacourtia ramontchi.
Flavivirus Cross-Reactivity to Dengue Nonstructural Protein 1 Antigen Detection Assays.
Flavivirus induces and antagonizes antiviral RNA interference in both mammals and mosquitoes.
Flavivirus NS1 Triggers Tissue-Specific Vascular Endothelial Dysfunction Reflecting Disease Tropism.
Full-length dengue virus RNA-dependent RNA polymerase - RNA/DNA complexes. Stoichiometries, intrinsic affinities, cooperativities, base, and conformational specificities.
Functional analysis of two cavities in flavivirus NS5 polymerase.
Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase.
Generation and characterization of a rat monoclonal antibody against the RNA polymerase protein from Dengue Virus-2.
GeneSV - an Approach to Help Characterize Possible Variations in Genomic and Protein Sequences.
Glutathionylation of dengue and Zika NS5 proteins affects guanylyltransferase and RNA dependent RNA polymerase activities.
Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups.
High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever.
High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity.
High-Level Expression of Functionally Active Dengue-2 Non-Structural Antigen 1 Production in Escherichia coli.
Highly conserved region 141?168 of the NS1 protein is a new common epitope region of dengue virus.
Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism.
Human glucose-regulated protein 78 modulates intracellular production and secretion of nonstructural protein 1 of dengue virus.
Identification and molecular characterization of human antibody fragments specific for dengue NS5 protein.
Identification of a Broad-Spectrum Viral Inhibitor Targeting a Novel Allosteric Site in the RNA-Dependent RNA Polymerases of Dengue Virus and Norovirus.
Identification of a Conserved RNA-dependent RNA Polymerase (RdRp)-RNA Interface Required for Flaviviral Replication.
Identification of a Pyridoxine-Derived Small-Molecule Inhibitor Targeting Dengue Virus RNA-Dependent RNA Polymerase.
Identification of Dengue Viral RNA Dependent RNA Polymerase Inhibitor using Computational Fragment Based Approaches and Molecular Dynamics Study.
Identification of human hnRNP C1/C2 as a dengue virus NS1-interacting protein.
Identification of the critical linker residues conferring differences in the compactness of NS5 from Dengue virus serotype 4 and NS5 from Dengue virus serotypes 1-3.
Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign.
Immunization of mice with dengue structural proteins and nonstructural protein NS1 expressed by baculovirus recombinant induces resistance to dengue virus encephalitis.
Immunization of mice with recombinant vaccinia virus expressing authentic dengue virus nonstructural protein NS1 protects against lethal dengue virus encephalitis.
Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus vaccination.
Immunofluorescence-based biosensor for the determination of dengue virus NS1 in clinical samples.
Impact of Dengue Vaccination on Serological Diagnosis: Insights From Phase III Dengue Vaccine Efficacy Trials.
Improved Immunoassay Sensitivity in Serum as a Result of Polymer-Entrapped Quantum Dots: 'Papaya Particles'.
Improving dengue viral antigens detection in dengue patient serum specimens using a low pH glycine buffer treatment.
In vitro RNA synthesis from exogenous dengue viral RNA templates requires long range interactions between 5'- and 3'-terminal regions that influence RNA structure.
Infant Dengue a 10-Year Experience from a Tertiary Center in South India.
Inferring Protective CD8+ T-Cell Epitopes for NS5 Protein of Four Serotypes of Dengue Virus Chinese Isolates Based on HLA-A, -B and -C Allelic Distribution: Implications for Epitope-Based Universal Vaccine Design.
Inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses.
Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities.
Insights on Dengue and Zika NS5 RNA-dependent RNA polymerase (RdRp) inhibitors.
Interaction of dengue virus nonstructural protein 5 with Daxx modulates RANTES production.
Interference of dengue replication by blocking the access of 3' SL RNA to the viral RNA-dependent RNA polymerase.
Intradermal Delivery of Dendritic Cell-Targeting Chimeric mAbs Genetically Fused to Type 2 Dengue Virus Nonstructural Protein 1.
Investigating Dengue Virus Nonstructural Protein 5 (NS5) Nuclear Import.
In vitro antiviral activities of extracts derived from Daucus maritimus seeds.
Ivermectin Accelerates Circulating Nonstructural Protein 1 (NS1) Clearance in Adult Dengue Patients: A Combined Phase 2/3 Randomized Double-blinded Placebo Controlled Trial.
Ivermectin is a specific inhibitor of importin ?/?-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus.
Kinetics of plasma viremia and soluble nonstructural protein 1 concentrations in dengue: differential effects according to serotype and immune status.
Laboratory diagnostics of dengue fever: An emphasis on the role of commercial dengue virus nonstructural protein 1 antigen rapid test.
Liver injury caused by antibodies against dengue virus nonstructural protein 1 in a murine model.
Looking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approach.
Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability.
Mass spectrometric analysis of host cell proteins interacting with dengue virus nonstructural protein 1 in dengue virus-infected HepG2 cells.
Maternal and Neonatal Outcomes during Dengue Infection Outbreak at a Tertiary National Hospital in Endemic Area of Indonesia.
Membrane undulation induced by NS4A of Dengue virus: a molecular dynamics simulation study.
Mice immunized with recombinant vaccinia virus expressing dengue 4 virus structural proteins with or without nonstructural protein NS1 are protected against fatal dengue virus encephalitis.
Modification of S-Adenosyl-l-Homocysteine as Inhibitor of Nonstructural Protein 5 Methyltransferase Dengue Virus Through Molecular Docking and Molecular Dynamics Simulation.
Modulation of the nucleoside triphosphatase/RNA helicase and 5'-RNA triphosphatase activities of Dengue virus type 2 nonstructural protein 3 (NS3) by interaction with NS5, the RNA-dependent RNA polymerase.
Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5).
Molecular epidemiology of dengue virus serotype 2 in the taiwan 2002 outbreak with envelope gene and nonstructural protein 1 gene analysis.
Molecular Investigation of Dengue virus serotype 2 Circulation in Kassala State, Sudan.
Molecular mimicry of human endothelial cell antigen by autoantibodies to nonstructural protein 1 of dengue virus.
Mosquito protein kinase G phosphorylates flavivirus NS5 and alters flight behavior in aedes aegypti and anopheles gambiae.
Mutagenesis of the Dengue virus type 2 NS3 protein within and outside helicase motifs: effects on enzyme activity and virus replication.
N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase.
Nanodelivery system enhances the immunogenicity of dengue-2 nonstructural protein 1, DENV-2 NS1.
Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase.
Nonstructural protein 1 antibody-based epitope-blocking enzyme-linked immunosorbent assay to differentiate Japanese encephalitis virus from dengue virus infections in humans.
Nonstructural protein NS1 immunodominant epitope detected specifically in dengue virus infected material by a SELDI-TOF/MS based assay.
Nonstructural protein NS1: giving a new structure to dengue diagnosis.
Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase.
NS5 from Dengue Virus Serotype 2 Can Adopt a Conformation Analogous to That of Its Zika Virus and Japanese Encephalitis Virus Homologues.
Nuclear localization of dengue virus nonstructural protein 5 does not strictly correlate with efficient viral RNA replication and inhibition of type I interferon signaling.
Nuclear localization of dengue virus nonstructural protein 5 through its importin alpha/beta-recognized nuclear localization sequences is integral to viral infection.
Nuclear localization of flavivirus RNA synthesis in infected cells.
Nucleotide sequence and deduced amino acid sequence of the nonstructural proteins of dengue type 3 virus, Bangkok genotype.
Nucleotide sequences of the nonstructural protein NS1 gene of three dengue-2 viruses, M1, M2 and M3, isolated in Malaysia from patients with dengue haemorrhagic fever, dengue shock syndrome and dengue fever, respectively.
Oriented Immobilization of Single-Domain Antibodies Using SpyTag/SpyCatcher Yields Improved Limits of Detection.
Outbreak of Dengue Virus Type 2 - American Samoa, November 2016-October 2018.
Partial nucleotide sequencing and molecular evolution of epidemic causing Dengue 2 strains.
Peptides targeting dengue viral nonstructural protein 1 inhibit dengue virus production.
Phylogenetically based establishment of a dengue virus panel, representing all available genotypes, as a tool in dengue drug discovery.
Platelet activation and aggregation response to dengue virus nonstructural protein 1 and domains.
Point-of-Use Nanobiosensor for Detection of Dengue Virus NS1 Antigen in Adult Aedes aegypti: A Potential Tool for Improved Dengue Surveillance.
Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.
Potential application of nonstructural protein NS1 serotype-specific immunoglobulin G enzyme-linked immunosorbent assay in the seroepidemiologic study of dengue virus infection: correlation of results with those of the plaque reduction neutralization test.
Potential Phosphorylation of Viral Nonstructural Protein 1 in Dengue Virus Infection.
Prevalence of Dengue Fever in Western Uttar Pradesh, India: A Gender-Based Study.
Production and characterization of monospecific and bispecific antibodies against dengue virus NS1 protein.
Production of a recombinant Dengue virus 2 NS5 protein and the potential use as a vaccine antigen.
Proper processing of dengue virus nonstructural glycoprotein NS1 requires the N-terminal hydrophobic signal sequence and the downstream nonstructural protein NS2a.
Proposing drug fragments for dengue virus NS5 protein.
Protection against Dengue Virus Infection in Mice by Administration of Antibodies against Modified Nonstructural Protein 1.
Quercetin derivatives as non-nucleoside inhibitors for dengue polymerase: molecular docking, molecular dynamics simulation and binding free energy calculation.
Re-evaluation of the pathogenic roles of nonstructural protein 1 and its antibodies during dengue virus infection.
Recombinant dengue type 1 virus NS5 protein expressed in Escherichia coli exhibits RNA-dependent RNA polymerase activity.
Recombinant dengue virus type 1 NS3 protein exhibits specific viral RNA binding and NTPase activity regulated by the NS5 protein.
Reduced Featured k-NN Classifier Model Optimal for Classification of Dengue Fever from Salivary Raman Spectra.
Relationship between nonstructural protein 1 detection and plasma virus load in Dengue patients.
Relative contribution of nonstructural protein 1 in dengue pathogenesis.
Repositioning of RdRp Inhibitors against HCV NS5B Polymerase Utilizing Structure-Based Molecular Docking.
Repurposing Old Antibodies for New Diseases by Exploiting Cross-Reactivity and Multicolored Nanoparticles.
Rhabdomyolysis and dengue Fever: a case report and literature review.
RNA sequences and structures required for the recruitment and activity of the dengue virus polymerase.
Secreted complement regulatory protein clusterin interacts with dengue virus nonstructural protein 1.
Secreted dengue virus nonstructural protein NS1 is an atypical barrel-shaped high-density lipoprotein.
Secretion of Nonstructural Protein 1 of Dengue Virus from Infected Mosquito Cells: Facts and Speculations.
Serologic diagnosis of West Nile virus infection.
Serological evaluation of suspected West Nile virus human cases following its introduction during a dengue outbreak in Puerto Rico in 2007.
Serological evidence of leptospirosis in patients with a clinical suspicion of dengue in the State of Ceará, Brazil.
Serotype 1-specific monoclonal antibody-based antigen capture immunoassay for detection of circulating nonstructural protein NS1: Implications for early diagnosis and serotyping of dengue virus infections.
Serotype-Specific Anti-Dengue Virus NS1 Mouse Antibodies Cross-React with prM and Are Potentially Involved in Virus Production.
Serotype-specific detection of dengue viruses in a nonstructural protein 1-based enzyme-linked immunosorbent assay validated with a multi-national cohort.
Severe nonfebrile dengue infection in an adolescent after postoperative kidney transplantation: a case report.
Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference.
Space constrained homology modelling: the paradigm of the RNA-dependent RNA polymerase of dengue (type II) virus.
Specificity of NS1-based immunochromatographic tests for dengue virus with regard to the Zika virus protein.
Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening.
Strategies for the treatment of dengue virus infections: a narrative account.
Structure and function of the non-structural protein of dengue virus and its applications in antiviral therapy.
Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase.
Structure-Activity Relationship Study of Biflavonoids on the Dengue Virus Polymerase DENV-NS5 RdRp.
Study of the Langat virus RNA-dependent RNA polymerase through homology modeling.
Study on the Behavior of Dengue Viruses during Outbreaks with Reference to Entomological and Laboratory Surveillance in the Cuddalore, Nagapattinam, and Tirunelveli Districts of Tamil Nadu, India.
Substrate selectivity of Dengue and Zika virus NS5 polymerase towards 2'-modified nucleotide analogues.
SUMO Modification Stabilizes Dengue Virus Nonstructural Protein 5.
Suppressed humoral immunity is associated with dengue nonstructural protein NS1-elicited anti-death receptor antibody fractions in mice.
Surface-Enhanced Raman Spectroscopy-Based Sandwich Immunoassays for Multiplexed Detection of Zika and Dengue Viral Biomarkers.
Synthesis of dengue virus RNA in vitro: initiation and the involvement of proteins NS3 and NS5.
Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor.
Temperature and the field stability of a dengue rapid diagnostic test in the tropics.
Temperature requirements for initiation of RNA-dependent RNA polymerization.
The 37-amino-acid interdomain of dengue virus NS5 protein contains a functional NLS and inhibitory CK2 site.
The C-terminal 50 Amino Acid Residues of Dengue NS3 Protein Are Important for NS3-NS5 Interaction and Viral Replication.
The Clinical and Serological Profile of Pediatric Dengue.
The dengue virus nonstructural protein 1 (NS1) increases NF-?B transcriptional activity in HepG2 cells.
The Dengue Virus Nonstructural Protein 1 (NS1) Is Secreted from Mosquito Cells in Association with the Intracellular Cholesterol Transporter Chaperone Caveolin Complex.
The dengue virus NS5 protein as a target for drug discovery.
The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing.
The effect of freeze-dried Carica papaya leaf juice treatment on NS1 and viremia levels in dengue fever mice model.
The Good, the Bad, and the Shocking: The Multiple Roles of Dengue Virus Nonstructural Protein 1 in Protection and Pathogenesis.
The interdomain region of dengue NS5 protein that binds to the viral helicase NS3 contains independently functional importin beta 1 and importin alpha/beta-recognized nuclear localization signals.
The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain.
The nucleotide sequence of dengue type 4 virus: analysis of genes coding for nonstructural proteins.
The Role of NS5 Protein in Determination of Host Cell Range for Yellow Fever Virus.
The secreted form of dengue virus nonstructural protein NS1 is endocytosed by hepatocytes and accumulates in late endosomes: implications for viral infectivity.
The use of dengue nonstructural protein 1 antigen for the early diagnosis during the febrile stage in patients with dengue infection.
Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining.
Two RNA tunnel inhibitors bind in highly conserved sites in Dengue virus NS5 polymerase: structural and functional studies.
Use of a Rapid Test for Diagnosis of Dengue during Suspected Dengue Outbreaks in Resource-Limited Regions.
Use of a Recombinant Gamma-2 Herpesvirus Vaccine Vector against Dengue Virus in Rhesus Monkeys.
Use of dengue nonstructural protein 1 antigen for the early diagnosis of dengue infection.
Use of Urea Wash ELISA to Distinguish Zika and Dengue Virus Infections.
Using bioinformatics tools for the discovery of Dengue RNA-dependent RNA polymerase inhibitors.
Vesicular Stomatitis Virus and DNA Vaccines Expressing Zika Virus Nonstructural Protein 1 Induce Substantial but Not Sterilizing Protection against Zika Virus Infection.
Vimentin interacts with heterogeneous nuclear ribonucleoproteins and dengue nonstructural protein 1 and is important for viral replication and release.
Zika and Dengue Interactions in the Context of a Large Dengue Vaccine Clinical Trial in Latin America.
Zika Virus Disease Comparing Children and Adults in a Dengue-Endemic Setting.
Zika virus NS5 localizes at centrosomes during cell division.
[Comparison of Dengue viral nonstructural protein 1 antigen testing kits].
[To evaluate the neutralizing abilities of anti-dengue virus antibodies with nonstructural protein 1 antigen capture enzyme-linked immunosorbent assay]
Dermatitis, Phototoxic
A General Mechanism of Photoconversion of Green-to-Red Fluorescent Proteins Based on Blue and Infrared Light Reduces Phototoxicity in Live-Cell Single-Molecule Imaging.
Dermatomyositis
Clinicopathological analysis of mechanic's hand associated with dermatomyositis.
The long-term outcome of interstitial lung disease with anti-aminoacyl-tRNA synthetase antibodies.
[Autoantibodies of Inflammatory Myopathies: Update].
Desmoplastic Small Round Cell Tumor
A renal cell carcinoma with EWSR1-TFE3 fusion gene.
Diabetes Mellitus, Type 1
Involvement of the RNA-binding protein ARE/poly(U)-binding factor 1 (AUF1) in the cytotoxic effects of proinflammatory cytokines on pancreatic beta cells.
T-cell responses to enterovirus antigens in children with type 1 diabetes.
Diabetic Nephropathies
Identification of NOD2 as a novel target of RNA-binding protein HuR: evidence from NADPH oxidase-mediated HuR signaling in diabetic nephropathy.
Interplay between RNA-binding protein HuR and Nox4 as a novel therapeutic target in diabetic kidney disease.
DiGeorge Syndrome
'Black sheep' that don't leave the double-stranded RNA-binding domain fold.
A Collection of Pre-mRNA Splicing Mutants in Arabidopsis thaliana.
Integrative Analysis of NSCLC Identifies LINC01234 as an Oncogenic lncRNA that Interacts with HNRNPA2B1 and Regulates miR-106b Biogenesis.
N6-methyladenosine-dependent primary microRNA-126 processing activated PI3K-AKT-mTOR pathway drove the development of pulmonary fibrosis induced by nanoscale carbon black particles in rats.
The Core Microprocessor Component DiGeorge Syndrome Critical Region 8 (DGCR8) Is a Nonspecific RNA-binding Protein.
Diphtheria
Development, validation and implementation of a quadruplex real-time PCR assay for identification of potentially toxigenic corynebacteria.
Distal Myopathies
Welander distal myopathy is caused by a mutation in the RNA-binding protein TIA1.
Distemper
Canine distemper terminal and intergenic non-protein coding nucleotide sequences: completion of the entire CDV genome sequence.
Detection and Preliminary Characterization of Phocine Distemper Virus in a Stranded Harp Seal (Pagophilus groenlandicus) from the Gulf of St. Lawrence, Canada.
Development of a challenge-protective vaccine concept by modification of the viral RNA-dependent RNA polymerase of canine distemper virus.
Humoral immune response in dogs with old dog encephalitis and chromic distemper meningo-encephalitis.
DNA Virus Infections
Emerging antiviral drugs.
Highlights in the development of new antiviral agents.
Down Syndrome
Pattern recognition receptors acting in innate immune system of shrimp against pathogen infections.
Dwarfism
Regulation of Rice Tillering by RNA-Directed DNA Methylation at Miniature Inverted-Repeat Transposable Elements.
Dysostoses
tp53-dependent and independent signaling underlies the pathogenesis and possible prevention of Acrofacial Dysostosis - Cincinnati type.
Dyspnea
A randomized and comparative study to assess safety and efficacy of supplemental treatment of a herbal formulation - Aayudh Advance comprising essential oils in patients with corona virus 2019 (COVID-19).
Dystonia
Dystonia in RNA Polymerase III-Related Leukodystrophy.
Novel POLR1C mutation in RNA polymerase III-related leukodystrophy with severe myoclonus and dystonia.
Encephalitis
A novel complex formed between the flavivirus E and NS1 proteins: analysis of its structure and function.
Antiviral Effects of a Transgenic RNA-Dependent RNA-Polymerase.
Cold-inducible RNA-binding protein is an important mediator of alcohol-induced brain inflammation.
Determination of the intramolecular disulfide bond arrangement and biochemical identification of the glycosylation sites of the nonstructural protein NS1 of Murray Valley encephalitis virus.
Development of multiplex real-time reverse transcriptase PCR assays for detecting eight medically important flaviviruses in mosquitoes.
Humoral immune response in dogs with old dog encephalitis and chromic distemper meningo-encephalitis.
Immunization of mice with dengue structural proteins and nonstructural protein NS1 expressed by baculovirus recombinant induces resistance to dengue virus encephalitis.
Immunization of mice with recombinant vaccinia virus expressing authentic dengue virus nonstructural protein NS1 protects against lethal dengue virus encephalitis.
Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus vaccination.
Impaired T helper 1 function of nonstructural protein 3-specific T cells in Japanese patients with encephalitis with neurological sequelae.
Mice immunized with recombinant vaccinia virus expressing dengue 4 virus structural proteins with or without nonstructural protein NS1 are protected against fatal dengue virus encephalitis.
Nonstructural Protein L* Species Specificity Supports a Mouse Origin for Vilyuisk Human Encephalitis Virus.
Role of amphotericin B upon enhancement of protective immunity elicited by oral administration with liposome-encapsulated-Japanese encephalitis virus nonstructural protein 1 (NS1) in mice.
[A recombinant adenovirus expressing the NS1 nonstructural protein of tick-borne encephalitis virus: some characteristics of the immunologic basis of antiviral action]
Encephalitis, Arbovirus
Simultaneous detection of three mosquito-borne encephalitis viruses (eastern equine, La Crosse, and St. Louis) with a single-tube multiplex reverse transcriptase polymerase chain reaction assay.
Encephalitis, Japanese
A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication.
A structural view of the RNA-dependent RNA polymerases from the Flavivirus genus.
Activation of protein kinase R by hepatitis C virus RNA-dependent RNA polymerase.
Anti-apoptotic activity of Japanese encephalitis virus NS5 protein in human medulloblastoma cells treated with interferon-?.
Antibodies to bovine serum albumin in human sera: problems and solutions with casein-based ELISA in the detection of natural Japanese encephalitis virus infections.
Antibody to the nonstructural protein NS1 of Japanese encephalitis virus: potential application of mAb-based indirect ELISA to differentiate infection from vaccination.
Biochemical characterization of a recombinant Japanese encephalitis virus RNA-dependent RNA polymerase.
Blocking Double-Stranded RNA-Activated Protein Kinase PKR by Japanese Encephalitis Virus Nonstructural Protein 2A.
Characterization of Japanese encephalitis virus envelope protein expressed by recombinant baculoviruses.
Characterization of RNA synthesis, replication mechanism, and in vitro RNA-dependent RNA polymerase activity of Japanese encephalitis virus.
Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5.
DNA immunization with Japanese encephalitis virus nonstructural protein NS1 elicits protective immunity in mice.
Effect of the methyltransferase domain of Japanese encephalitis virus NS5 on the polymerase activity.
Expression and secretion of Japanese encephalitis virus nonstructural protein NS1 by insect cells using a recombinant baculovirus.
Flavivirus Nonstructural Protein NS5 Dysregulates HSP90 to Broadly Inhibit JAK/STAT Signaling.
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) interaction with 3' ends of Japanese encephalitis virus RNA and colocalization with the viral NS5 protein.
Identification and characterization of RNA-dependent RNA polymerase activity in recombinant Japanese encephalitis virus NS5 protein.
Identification of residues critical for the interferon antagonist function of Langat virus NS5 reveals a role for the RNA-dependent RNA polymerase domain.
Immunogenicity of baculovirus expressed recombinant proteins of Japanese encephalitis virus in mice.
In vitro synthesis of Japanese encephalitis virus (JEV) RNA: membrane and nuclear fractions of JEV-infected cells possess high levels of virus-specific RNA polymerase activity.
Inhibition of expression of rna polymerase with small interfering RNAs targeting a conserved motif in the respective viral genes in viruses of the family Flaviviridae.
Japanese encephalitis virus nonstructural protein NS5 interacts with mitochondrial trifunctional protein and impairs fatty acid ?-oxidation.
Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-?B.
Japanese encephalitis virus structural and nonstructural proteins expressed in Escherichia coli induce protective immunity in mice.
Last twenty amino acids of the West Nile Virus NS1' protein are responsible for its retention in cells and formation of unique heat-stable dimers.
Mechanistic insights into the Japanese encephalitis virus RNA dependent RNA polymerase protein inhibition by bioflavonoids from Azadirachta indica.
Modulatory effects of the human heat shock protein 70 on DNA vaccination.
Nanoparticle-Based LDI-MS Immunoassay for the Multiple Diagnosis of Viral Infections.
Nonstructural protein 1 antibody-based epitope-blocking enzyme-linked immunosorbent assay to differentiate Japanese encephalitis virus from dengue virus infections in humans.
NS5 from Dengue Virus Serotype 2 Can Adopt a Conformation Analogous to That of Its Zika Virus and Japanese Encephalitis Virus Homologues.
Nuclear localization of flavivirus RNA synthesis in infected cells.
Partial nucleotide sequence of Japanese encephalitis virus ling strain genome and comparison of the encoded structural proteins and nonstructural protein NS1 among Japanese encephalitis virus strains.
Persistence of Japanese encephalitis virus is associated with abnormal expression of the nonstructural protein NS1 in host cells.
Preparation of Japanese encephalitis virus nonstructural protein NS1 obtained from culture fluid of JEV-infected Vero cells.
Proteomic analyses identify intracellular targets for Japanese encephalitis virus nonstructural protein 1 (NS1).
Proteomic analysis for Type I interferon antagonism of Japanese encephalitis virus NS5 protein.
Purification and renaturation of Japanese encephalitis virus nonstructural glycoprotein NS1 overproduced by insect cells.
Recognition of nonstructural protein peptides by cytotoxic T lymphocytes raised against Japanese encephalitis virus.
RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state.
Structural Study of the C-Terminal Domain of Nonstructural Protein 1 from Japanese Encephalitis Virus.
Structure and function of the Zika virus full-length NS5 protein.
The C Terminus of the Core ?-Ladder Domain in Japanese Encephalitis Virus Nonstructural Protein 1 Is Flexible for Accommodation of Heterologous Epitope Fusion.
Utilization of complement-dependent cytotoxicity to measure low levels of antibodies: application to nonstructural protein 1 in a model of Japanese encephalitis virus.
Virus-specific cytolytic antibodies to nonstructural protein 1 of Japanese encephalitis virus effect reduction of virus output from infected cells.
Encephalitis, Tick-Borne
A database of human genes and a gene network involved in response to tick-borne encephalitis virus infection.
Affinity labelling of the tick-borne encephalitis virus RNA replicase proteins by 4-N-exo-base-substituted photoreactive CTP analogs.
An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice.
An RNA-dependent RNA polymerase inhibitor for tick-borne encephalitis virus.
Assessing ubiquitination of viral proteins: Lessons from flavivirus NS5.
Crystal structure of a tick-borne flavivirus RNA-dependent RNA polymerase suggests a host adaptation hotspot in RNA viruses.
Escape of tick-borne flavivirus from 2' -C-methylated nucleoside antivirals is mediated by a single conservative mutation in NS5 that has a dramatic effect on viral fitness.
Extension of flavivirus protein C differentially affects early RNA synthesis and growth in mammalian and arthropod host cells.
Identification of residues critical for the interferon antagonist function of Langat virus NS5 reveals a role for the RNA-dependent RNA polymerase domain.
Identification of RNA replicase subunits responsible for initiation of RNA synthesis of tick-borne encephalitis virus by affinity labelling.
Nonstructural Protein 1 of Tick-Borne Encephalitis Virus Induces Oxidative Stress and Activates Antioxidant Defense by the Nrf2/ARE Pathway.
Nucleotide sequence of the genome and complete amino acid sequence of the polyprotein of tick-borne encephalitis virus.
Phosphorylation of tick-borne encephalitis virus NS5 protein.
Synthesis of new photocross-linking 5-C-base-substituted UTP analogs and their application in highly selective affinity labelling of the tick-borne encephalitis virus RNA replicase proteins.
Tick-Borne Encephalitis Virus Nonstructural Protein NS5 Induces RANTES Expression Dependent on the RNA-Dependent RNA Polymerase Activity.
Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signalling.
TRIM79?, an interferon-stimulated gene product, restricts tick-borne encephalitis virus replication by degrading the viral RNA polymerase.
[A recombinant adenovirus expressing the NS1 nonstructural protein of tick-borne encephalitis virus: some characteristics of the immunologic basis of antiviral action]
[Humoral immune response to structural and nonstructural proteins of tick-borne encephalitis virus in the natural history of the disease]
[Nonstructural protein 1 of tick-borne encephalitis virus activates the expression of immunoproteasome subunits].
[Nonstructural protein NV5 of the tick-borne encephalitis virus possesses precipitating activity characteristic for the nonvirion (soluble) antigen]
[Protective activity of a bacterial plasmid, bearing the gene for the tick-borne encephalitis virus NS1 nonstructural protein]
[Synthetic fragments of the NS1 protein of the tick-borne encephalitis virus exhibiting a protective effect]
Encephalitis, Viral
Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-?B.
[Molecular Epidemiology of Echovirus 30 in Longyan City, Fujian, China, 2011?2014].
Encephalomyelitis
Antibody to parvovirus B19 nonstructural protein is associated with chronic arthralgia in patients with chronic fatigue syndrome/myalgic encephalomyelitis.
Avian encephalomyelitis virus nonstructural protein 2C induces apoptosis by activating cytochrome c/caspase-9 pathway.
Dysfunctional RNA-binding protein biology and neurodegeneration in experimental autoimmune encephalomyelitis in female mice.
Molecular analysis of three Ljungan virus isolates reveals a new, close-to-root lineage of the Picornaviridae with a cluster of two unrelated 2A proteins.
Posttranscriptional gene regulation of IL-17 by the RNA-binding protein HuR is required for initiation of experimental autoimmune encephalomyelitis.
Silencing of the RNA-binding protein HuR attenuates hyperalgesia and motor disability in experimental autoimmune encephalomyelitis.
Targeting the RNA-Binding Protein HuR Alleviates Neuroinflammation in Experimental Autoimmune Encephalomyelitis: Potential Therapy for Multiple Sclerosis.
TDP-43 proteinopathy in Theiler's murine encephalomyelitis virus infection.
The 2A proteins of three diverse picornaviruses are related to each other and to the H-rev107 family of proteins involved in the control of cell proliferation.
The cleavage activities of aphthovirus and cardiovirus 2A proteins.
The Theiler's murine encephalomyelitis virus leader protein is the only nonstructural protein tested that induces apoptosis when transfected into mammalian cells.
The VP1 protein of avian encephalomyelitis virus is a major host-protective immunogen that serves as diagnostic potential.
Theiler's murine encephalomyelitis virus 3D RNA polymerase: its expression in the CNS and the specific immune response generated in persistently infected mice.
Encephalomyelitis, Autoimmune, Experimental
Dysfunctional RNA-binding protein biology and neurodegeneration in experimental autoimmune encephalomyelitis in female mice.
Posttranscriptional gene regulation of IL-17 by the RNA-binding protein HuR is required for initiation of experimental autoimmune encephalomyelitis.
Silencing of the RNA-binding protein HuR attenuates hyperalgesia and motor disability in experimental autoimmune encephalomyelitis.
Targeting the RNA-Binding Protein HuR Alleviates Neuroinflammation in Experimental Autoimmune Encephalomyelitis: Potential Therapy for Multiple Sclerosis.
Encephalomyelitis, Eastern Equine
A comparison of the nucleotide sequences of eastern and western equine encephalomyelitis viruses with those of other alphaviruses and related RNA viruses.
Structural and nonstructural protein genome regions of eastern equine encephalitis virus are determinants of interferon sensitivity and murine virulence.
Encephalomyelitis, Venezuelan Equine
Hypervariable domain of nonstructural protein nsP3 of Venezuelan equine encephalitis virus determines cell-specific mode of virus replication.
Low-fidelity Venezuelan equine encephalitis virus polymerase mutants to improve live-attenuated vaccine safety and efficacy.
Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts.
[Activity and properties of RNA-dependent RNA polymerase induced in cell cultures infected with Venezuelan equine encephalomyelitis virus]
Encephalomyelitis, Western Equine
A comparison of the nucleotide sequences of eastern and western equine encephalomyelitis viruses with those of other alphaviruses and related RNA viruses.
Reverse transcription-PCR-enzyme-linked immunosorbent assay for rapid detection and differentiation of alphavirus infections.
[Similarities and differences between western equine encephalomyelitis viruses with respect to genes for nonstructural protein NSP2 and structural proteins C and E2]
Endocarditis
Culture-negative endocarditis due to Bartonella quintana.
Endodermal Sinus Tumor
RNA-binding protein LIN28 is a sensitive marker of pediatric yolk sac tumors.
Endometrial Hyperplasia
Expression of cold-inducible RNA-binding protein in the normal endometrium, endometrial hyperplasia, and endometrial carcinoma.
Endometrial Neoplasms
Expression of cold-inducible RNA-binding protein in the normal endometrium, endometrial hyperplasia, and endometrial carcinoma.
[Antisense oligodeoxynucleotides of human telomerase reverse transcriptase inhibit endometrial carcinoma cell HEC-1A proliferation]
Endotoxemia
Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog.
Enteritis
Calicivirus infection in pediatric small intestine transplant recipients: pathological considerations.
Evidence for recombination in neboviruses.
Mink Enteritis Virus Infection Induces Mitochondrion-mediated Apoptosis by the Viral Nonstructural Protein 1.
Enterocolitis
Incidence of and factors associated with false positives in laboratory diagnosis of norovirus infection by amplification of the RNA-dependent RNA polymerase gene.
Enterovirus Infections
Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and viral persistence.
Enzootic Bovine Leukosis
Bovine leukemia virus: an exogenous RNA oncogenic virus.
Bovine leukemia virus: an exogenous RNA oncogenic virus?
RNA polymerase isolated from bovine lymphosarcoma by sequential low- and high-salt extraction.
Eosinophilia
Interleukin-5 mRNA in three T-cell lymphomas with eosinophilia.
Ependymoma
TERTp Mutation Detection in Plasma by Droplet-Digital Polymerase Chain Reaction in Spinal Myxopapillary Ependymoma with Lung Metastases.
Ephemeral Fever
Finding potential inhibitors against RNA-dependent RNA polymerase (RdRp) of bovine ephemeral fever virus (BEFV): an in-silico study.
RNA polymerase (L) gene and genome terminal sequences of ephemeroviruses bovine ephemeral fever virus and Adelaide River virus indicate a close relationship to vesiculoviruses.
Epilepsy
Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice.
CELF4 regulates translation and local abundance of a vast set of mRNAs, including genes associated with regulation of synaptic function.
Etiology of a genetically complex seizure disorder in Celf4 mutant mice.
RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy.
Erythema Infectiosum
Antibodies to the nonstructural protein of parvovirus B19 in persistently infected patients: implications for pathogenesis.
[Detection of human parvovirus B19 nonstructural protein DNA by nested- polymerase chain reaction in pregnant women]
Esophageal Neoplasms
Nicotine-Induced ILF2 Facilitates Nuclear mRNA Export of Pluripotency Factors to Promote Stemness and Chemoresistance in Human Esophageal Cancer.
Overexpression of miR-214-3p in esophageal squamous cancer cells enhances sensitivity to cisplatin by targeting survivin directly and indirectly through CUG-BP1.
Esophageal Squamous Cell Carcinoma
Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma.
Essential Tremor
FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis.
The role of FUS gene variants in neurodegenerative diseases.
Exanthema
Integrated Diagnosis Project for Inflammatory Myopathies: An association between autoantibodies and muscle pathology.
Skeletal Muscle Involvement in Antisynthetase Syndrome.
[Antisynthetase myopathy].
Fatty Liver
Mice Deficient in the RNA-Binding Protein Zfp871 Are Prone to Early Death and Steatohepatitis in Part through the p53-Mdm2 Axis.
SIRT1 mediates the role of RNA-binding protein QKI 5 in the synthesis of triglycerides in non-alcoholic fatty liver disease mice via the PPAR?/FoxO1 signaling pathway.
Feline Panleukopenia
A nonstructural protein of feline panleukopenia virus: expression in Escherichia coli and detection of multiple forms in infected cells.
Fibroadenoma
Immunohistochemical evaluation of reverse transcriptase in breast carcinoma with polyclonal antibodies raised in rabbit.
Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas.
Flavivirus Infections
Comparison of centrifugation methods for molecular and morphological analysis of membranes associated with RNA replication of the flavivirus Kunjin.
Enzyme-linked immunosorbent assay specific to Dengue virus type 1 nonstructural protein NS1 reveals circulation of the antigen in the blood during the acute phase of disease in patients experiencing primary or secondary infections.
Highly Sensitive Detection of Zika Virus Nonstructural Protein 1 in Serum Samples by a Two-Site Nanobody ELISA.
Nuclear localisation of West Nile virus NS5 protein modulates host gene expression.
Purification and renaturation of Japanese encephalitis virus nonstructural glycoprotein NS1 overproduced by insect cells.
The C Terminus of the Core ?-Ladder Domain in Japanese Encephalitis Virus Nonstructural Protein 1 Is Flexible for Accommodation of Heterologous Epitope Fusion.
Vesicular Stomatitis Virus and DNA Vaccines Expressing Zika Virus Nonstructural Protein 1 Induce Substantial but Not Sterilizing Protection against Zika Virus Infection.
Foot-and-Mouth Disease
A cell adhesion peptide from foot-and-mouth disease virus can direct cell targeted delivery of a functional enzyme.
A novel bi-functional DNA vaccine expressing VP1 protein and producing antisense RNA targeted to 5'UTR of foot-and-mouth disease virus can induce both rapid inhibitory effect and specific immune response in mice.
A peptide construct containing B-cell and T-cell epitopes from the foot-and-mouth disease viral VP1 protein induces efficient antiviral protection.
A peptide vaccine administered transcutaneously together with cholera toxin elicits potent neutralising anti-FMDV antibody responses.
A recombinant foot-and-mouth disease virus antigen inhibits DNA replication and triggers the SOS response in Escherichia coli.
A single amino acid substitution in nonstructural protein 3A can mediate adaptation of foot-and-mouth disease virus to the guinea pig.
A T cell epitope in VP1 of foot-and-mouth disease virus is immunodominant for vaccinated cattle.
Accuracy of herdsmen reporting versus serologic testing for estimating foot-and-mouth disease prevalence.
Activity of foot-and-mouth disease virus RNA-dependent RNA polymerase in vitro: inhibition by polyamines and poly(amino acid)s.
An efficient colorimetric assay for RNA synthesis by viral RNA-dependent RNA polymerases, using thermostable pyrophosphatase.
An ELISA based on the repeated foot-and-mouth disease virus 3B epitope peptide can distinguish infected and vaccinated cattle.
An increased replication fidelity mutant of foot-and-mouth disease virus retains fitness in vitro and virulence in vivo.
Antigenicity of a viral peptide displayed on beta-galactosidase fusion proteins is influenced by the presence of the homologous partner protein.
Association of foot-and-mouth disease virus induced RNA polymerase with host cell organelles.
Attenuation of Foot-and-Mouth Disease Virus by Engineered Viral Polymerase Fidelity.
Biosensor characterization of antigenic site A of foot-and-mouth disease virus presented in different vector systems.
Both cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication.
Bovine serum panel for evaluating foot-and-mouth disease virus nonstructural protein antibody tests.
Cellular Vimentin Interacts with Foot-and-Mouth Disease Virus Nonstructural Protein 3A and Negatively Modulates Viral Replication.
Characterization of a foot-and-mouth disease mutant temperature-sensitive for viral RNA synthesis.
Characterization of a full-length infectious cDNA clone and a green fluorescent protein reporter derivative of the oncolytic picornavirus SVV-001.
Chimeric hepatitis B virus core particles as probes for studying peptide-integrin interactions.
Coexpression of interleukin-12 chains by a self-splicing vector increases the protective cellular immune response of DNA and Mycobacterium bovis BCG vaccines against Mycobacterium tuberculosis.
Comparative Evaluation of Three Commercial ELISA Kits for Detection of Antibodies to a Nonstructural Protein of Foot-and-Mouth Disease Virus.
Comparative evaluation of two ELISA kits for detecting antibodies to a nonstructural protein of foot-and-mouth disease virus using serum samples collected from naturally and experimentally infected cows.
Comparison of immune responses against foot-and-mouth disease virus induced by fusion proteins using the swine IgG heavy chain constant region or beta-galactosidase as a carrier of immunogenic epitopes.
Conformational flexibility in a highly mobile protein loop of foot-and-mouth disease virus: distinct structural requirements for integrin and antibody binding.
Construction and characterization of 3A-epitope-tagged foot-and-mouth disease virus.
Contribution of a Multifunctional Polymerase Region of Foot-and-Mouth Disease Virus to Lethal Mutagenesis.
Converging antigenic structure of a recombinant viral peptide displayed on different frameworks of carrier proteins.
Counteracting quasispecies adaptability: extinction of a ribavirin-resistant virus mutant by an alternative mutagenic treatment.
Delivery of a foot-and-mouth disease virus empty capsid subunit antigen with nonstructural protein 2B improves protection of swine.
Design and construction of African swine fever virus chimeras incorporating foreign viral epitopes.
Detection of antibodies specific for foot-and-mouth disease virus infection using indirect ELISA based on recombinant nonstructural protein 2B.
Detergent-solubilized RNA polymerase from cells infected with foot-and-mouth disease virus.
Determinants of RNA-dependent RNA polymerase (in)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin.
Development and evaluation of an indirect enzyme-linked immunosorbent assay for detection of foot-and-mouth disease virus nonstructural protein antibody using a chemically synthesized 2B peptide as antigen.
Development of a foot-and-mouth disease NSP ELISA and its comparison with differential diagnostic methods.
Development of a recombinant vaccine against foot and mouth disease utilizing mutant attenuated Listeria ivanovii strain as a live vector.
Development of synthetic peptide ELISA based on nonstructural protein 2C of foot and mouth disease virus.
Diagnostic potential of recombinant nonstructural protein 3B to detect antibodies induced by foot-and-mouth disease virus infection in bovines.
Differentiation of foot-and-mouth disease virus-infected from vaccinated pigs by enzyme-linked immunosorbent assay using nonstructural protein 3AB as the antigen and application to an eradication program.
Discriminating foot-and-mouth disease virus-infected and vaccinated animals by use of beta-galactosidase allosteric biosensors.
Distinct mechanisms of antibody-mediated enzymatic reactivation in beta-galactosidase molecular sensors.
eEF1G interaction with foot-and-mouth disease virus nonstructural protein 2B: Identification by yeast two-hybrid system.
Effects of temperature on viral RNA synthesis and RNA polymerase activity in a foot-and-mouth disease virus system.
Efficient inhibition of foot-and-mouth disease virus replication in vitro by artificial microRNA targeting 3D polymerase.
Erratum to: The carboxy-terminal half of nonstructural protein 3A is not essential for foot-and-mouth disease virus replication in cultured cell lines.
Evaluation of primers for PCR amplification of RNA polymerase gene sequences of foot-and-mouth disease virus.
Evidence of VP1 of duck hepatitis A type 1 virus as a target of neutralizing antibodies and involving receptor-binding activity.
Expression and Stability of Foreign Epitopes Introduced into 3A Nonstructural Protein of Foot-and-Mouth Disease Virus.
Expression of a foot-and-mouth disease virus immunodominant epitope by a filamentous bacteriophage vector.
Expression of an active foot-and-mouth disease virus RNA polymerase in Escherichia coli.
Expression of the Foot-and-Mouth Disease Virus VP1 protein using a replication-competent recombinant canine adenovirus type 2 elicits a humoral antibody response in a porcine model.
Expression of VP1 protein of serotype A and O of foot-and-mouth disease virus in transgenic sunnhemp plants and its immunogenicity for guinea pigs.
Expression, purification, crystallization and preliminary X-ray diffraction analysis of swine leukocyte antigen 2 complexed with a CTL epitope AS64 derived from Asia1 serotype of foot-and-mouth disease virus.
Extension of flavivirus protein C differentially affects early RNA synthesis and growth in mammalian and arthropod host cells.
Factors required for the Uridylylation of the foot-and-mouth disease virus 3B1, 3B2, and 3B3 peptides by the RNA-dependent RNA polymerase (3Dpol) in vitro.
Field outbreak strains of serotype O foot-and-mouth disease virus from India with a deletion in the immunodominant ?G-?H loop of the VP1 protein.
Foot-and-mouth disease virus low-fidelity polymerase mutants are attenuated.
Foot-and-mouth disease virus nonstructural protein 2B interacts with cyclophilin A, modulating virus replication.
Foot-and-mouth disease virus particles contain replicase protein 3D.
Foot-and-mouth disease virus type O specific mutations determine RNA-dependent RNA polymerase fidelity and virus attenuation.
Foot-and-mouth disease virus VP1 protein fused with cholera toxin B subunit expressed in Chlamydomonas reinhardtii chloroplast.
Foot-and-mouth disease virus, but not bovine enterovirus, targets the host cell cytoskeleton via the nonstructural protein 3Cpro.
Foot-and-mouth disease virus-induced RNA polymerase is associated with Golgi apparatus.
Foot-and-mouth disease virus-infected but not vaccinated cattle develop antibodies against recombinant 3AB1 nonstructural protein.
Formation of higher-order foot-and-mouth disease virus 3D(pol) complexes is dependent on elongation activity.
Function of the RNA Coliphage Q? Proteins in Medical In Vitro Evolution.
Further evaluation of an ELISA kit for detection of antibodies to a nonstructural protein of foot-and-mouth disease virus.
High-affinity antibody induced by immunization with a synthetic peptide is associated with protection of cattle against foot-and-mouth disease.
Homology Modeling and Analysis of Structure Predictions of the Bovine Rhinitis B Virus RNA Dependent RNA Polymerase (RdRp).
Identification of a conformational neutralizing epitope on the VP1 protein of type A foot-and-mouth disease virus.
Identification of a conserved linear epitope on the VP1 protein of serotype O foot-and-mouth disease virus by neutralising monoclonal antibody 8E8.
Identification of amino acid and nucleotide sequence of the foot-and-mouth disease virus RNA polymerase.
Immunogenicity of plasmids encoding T and B cell epitopes of foot-and-mouth disease virus (FMDV) in swine.
Improved immunogenicity of a peptide epitope after fusion to hepatitis B core protein.
Improving baculovirus transduction of mammalian cells by surface display of a RGD-motif.
Increased efficacy of an adenovirus-vectored foot-and-mouth disease capsid subunit vaccine expressing nonstructural protein 2B is associated with a specific T cell response.
Indirect ELISA using recombinant nonstructural protein 3D to detect foot and mouth disease virus infection associated antibodies.
Induction of a protective response in swine vaccinated with DNA encoding foot-and-mouth disease virus empty capsid proteins and the 3D RNA polymerase.
Induction of active immune suppression by co-immunization with DNA- and protein-based vaccines.
Influence of hydrophilic amino acids and GC-content on expression of recombinant proteins used in vaccines against foot-and-mouth disease virus in Escherichia coli.
Inhibition of the foot-and-mouth disease virus subgenomic replicon by RNA aptamers.
Inhibitors of foot and mouth disease virus targeting a novel pocket of the RNA-dependent RNA polymerase.
Insertion of a 27 amino acid viral peptide in different zones of Escherichia coli beta-galactosidase: effects on the enzyme activity.
Inter-laboratory comparison of 2 ELISA kits used for foot-and-mouth disease virus nonstructural protein serology.
Interaction of foot-and-mouth disease virus nonstructural protein 3A with host protein DCTN3 is important for viral virulence in cattle.
Intranasal immunization of guinea pigs with an immunodominant foot-and-mouth disease virus peptide conjugate induces mucosal and humoral antibodies and protection against challenge.
Isolation of a soluble and template-dependent foot-and-mouth disease virus RNA polymerase.
Isolation of novel sequences targeting highly variable viral protein hemagglutinin.
Leader protein of foot-and-mouth disease virus is required for cleavage of the p220 component of the cap-binding protein complex.
Liposome encapsulated subunit (VP1) and virion vaccines against foot-and-mouth disease.
Molecular characterization of a dual inhibitory and mutagenic activity of 5-fluorouridine triphosphate on viral RNA synthesis. Implications for lethal mutagenesis.
Molecular characterization of amino acid deletion in VP1 (1D) protein and novel amino acid substitutions in 3D polymerase protein of foot and mouth disease virus subtype A/Iran87.
Monoclonal antibodies against foot-and-mouth disease virus RNA polymerase for detection of virus infection.
Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition.
Mutations that hamper dimerization of foot-and-mouth disease virus 3A protein are detrimental for infectivity.
New virus-specific T-helper epitopes of foot-and-mouth disease viral VP1 protein.
Novel purification method for recombinant 3AB1 nonstructural protein of foot-and-mouth disease virus for use in differentiation between infected and vaccinated animals.
Observations and implications of proteolysis in preparations of foot-and-mouth disease virus.
Orientation of epitopes influences the immunogenicity of synthetic peptide dimers.
Outer membrane protein PhoE as a carrier for the exposure of foreign antigenic determinants at the bacterial cell surface.
Pan-Serotype Diagnostic for Foot-and-Mouth Disease Using the Consensus Antigen of Nonstructural Protein 3B.
Peptides Interfering 3A Protein Dimerization Decrease FMDV Multiplication.
Phylogenic analysis of serotype Asia1 foot-and-mouth disease virus from Sulaimani/Iraq using VP1 protein: heterogeneity with vaccine strain As1/Shamir/89.
PI3K-Akt signaling and viral infection.
Polymerase Fidelity Contributes to Foot-and-Mouth Disease Virus Pathogenicity and Transmissibility In Vivo.
Production of foot-and-mouth disease virus SAT2 VP1 protein.
Purification and identification of the RNA-dependent RNA polymerase of foot-and-mouth disease virus.
Purification and immunogenicity of fusion VP1 protein of foot and mouth disease virus.
Purification, crystallization and preliminary X-ray crystallographic studies of swine MHC class I complexed with an FMDV CTL epitope Hu64.
Radioimmunoassay for detection of VP1 specific neutralizing antibodies of foot and mouth disease virus.
Re-emergence of circulatory foot-and-mouth disease virus serotypes Asia1 in Bangladesh and VP1 protein heterogeneity with vaccine strain IND 63/72.
Recombinant adenovirus expression of FMDV P1-2A and 3C protein and its immune response in mice.
Recombinant fusion protein and DNA vaccines against foot and mouth disease virus infection in guinea pig and swine.
Recombinant pseudorabies virus expressing P12A and 3C of FMDV can partially protect piglets against FMDV challenge.
Recombination patterns in aphthoviruses mirror those found in other picornaviruses.
Recovery of infectious type Asia1 foot-and-mouth disease virus from suckling mice directly inoculated with an RNA polymerase I/II-driven unidirectional transcription plasmid.
Repeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of foot-and-mouth disease virus in host cells.
Residues within the Foot-and-Mouth Disease Virus 3Dpol Nuclear Localization Signal Affect Polymerase Fidelity.
Ribavirin-Resistant Variants of Foot-and-Mouth Disease Virus: the Effect of Restricted Quasispecies Diversity on Viral Virulence.
RNA-dependent RNA polymerase gene sequence from foot-and-mouth disease virus in Hong Kong.
Selection and characterization of RNA aptamers to the RNA-dependent RNA polymerase from foot-and-mouth disease virus.
Sequence analysis of the RNA polymerase gene of foot-and-mouth disease virus serotype Asia1.
Serological survey for foot-and-mouth disease virus in wildlife in eastern Africa and estimation of test parameters of a nonstructural protein enzyme-linked immunosorbent assay for buffalo.
Short hairpin RNA targeted to the highly conserved 2B nonstructural protein coding region inhibits replication of multiple serotypes of foot-and-mouth disease virus.
Specific interactions between human integrin alpha v beta 3 and chimeric hepatitis B virus core particles bearing the receptor-binding epitope of foot-and-mouth disease virus.
Spermidine stimulation of foot-and-mouth disease virus RNA-dependent RNA polymerase activity.
Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA.
Structure-function analysis of mutant RNA-dependent RNA polymerase complexes with VPg.
Study of the immunogenicity of different recombinant Mengo viruses expressing HIV1 and SIV epitopes.
Synthesis and in-vitro evaluation of 2-amino-4-arylthiazole as inhibitor of 3D polymerase against foot-and-mouth disease (FMD).
Synthetic vaccine against foot-and-mouth disease based on a palmitoyl derivative of the VP1 protein 135-159 fragment of the A22 virus strain.
T135I substitution in the nonstructural protein 2C enhances foot-and-mouth disease virus replication.
The carboxy-terminal half of nonstructural protein 3A is not essential for foot-and-mouth disease virus replication in cultured cell lines.
The cell attachment site on foot-and-mouth disease virus includes the amino acid sequence RGD (arginine-glycine-aspartic acid).
The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases.
The nucleotide sequence of the structural-protein-coding region of foot-and-mouth disease virus serotype SAT3.
The plasmid constructs producing shRNA corresponding to the conserved 3D polymerase of Foot and Mouth Disease virus protects guinea pigs against challenge virus.
The position of the heterologous domain can influence the solubility and proteolysis of beta-galactosidase fusion proteins in E. coli.
The possible use of native foot-and-mouth disease nonstructural protein 3A in a serological screening test.
The potential of retro-inverso peptides as synthetic vaccines.
The VP1 S154D mutation of type Asia1 foot-and-mouth disease virus enhances viral replication and pathogenicity.
Topology of PhoE porin: the 'eyelet' region.
Transient inhibition of foot-and-mouth disease virus replication by siRNAs silencing VP1 protein coding region.
Use of a standardized bovine serum panel to evaluate a multiplexed nonstructural protein antibody assay for serological surveillance of foot-and-mouth disease.
Use of confocal immunofluorescence microscopy to localize viral nonstructural proteins and potential sites of replication in pigs experimentally infected with foot-and-mouth disease virus.
Use of in situ hybridization for the detection of foot-and-mouth disease virus in cell culture.
Use of outer membrane protein PhoE as a carrier for the transport of a foreign antigenic determinant to the cell surface of Escherichia coli K-12.
VP1 protein of Foot-and-mouth disease virus (FMDV) impairs baculovirus surface display.
[Antigenic structure of foot-and-mouth virus. IV. Synthesis and immunogenic properties of new fragments of the VP1 protein of food-and-mouth virus strain A22]
[Antigenic structure of the foot-and-mouth disease virus. II. Synthesis of protective peptides from the major immunogenic region of VP1 protein of foot-and-mouth disease virus type A22]
[Antigenic structure of the foot-and-mouth virus. VI. Functional segments of the immunodominant region of the VP1 protein of foot-and-mouth virus strains O1K and A22]
[Cloning fragments of the RNA polymerase gene of an attenuated variant of the foot-and-mouth disease virus A22]
[Comparison of the immunogenic potencies of purified inactivated foot-and-mouth disease virus particles with variable amounts of VP1 protein (author's transl)]
[Establishment of BHK-21 cell lines stably expressing FMDV 3Dpol gene by retroviral-mediated gene transfer technique]
[Expression and utilization of 3AB nonstructural protein of foot-and-mouth disease virus in Escherichia coli].
[Molecular basis of changes in biological properties of foot and mouth disease virus of subtype A22]
[Nucleotide sequence of the RNA polymerase gene attenuated by a variant of foot-and-mouth disease virus and its comparison with the virulence of related variants of subtype A22]
[Primary structure of the 3'-terminal region of the RNA-polymerase gene in foot-and-mouth virus A22]
[Primary structure of the A22 RNA polymerase gene of the foot and mouth disease virus]
[Primary structure of the gene for VP1 protein of the foot-and-mouth disease virus of Asia 1 serotype]
[Prokaryotic expression and bioreactivity analysis of a major epitope region of 2C with 3AB within non-structural protein of foot-and-mouth disease virus]
[Secreted expression of nonstructural protein gene 3ABC of foot-and-mouth disease virus in Sf9 cells and activity analysis]
[Study on the DNA vaccine against foot-and-mouth disease virus using the heavy chain constant region of swine IgG as the carrier for peptide epitopes]
[Synthesis and immunogenic properties of peptides--fragments of the immunodominant regions of the VP1 protein of the Asia-1 type of foot- and-mouth disease virus]
[Synthesis of new fragments of VP1 protein fragments from foot and mouth disease virus type A22. Synthesis of fragments 134-139, 134-145, 140-145, 150-155, and 150-159]
[Synthetic immunogenic complexes containing a peptide from the surface protein of the foot-and-mouth disease virus]
[Synthetic peptide designs based on immunoactive fragments of the VP1 protein of the foot-and-mouth disease virus strain A22]
[Synthetic peptides simulating the protective epitopes of VP1 protein of foot-and-mouth disease virus type O and A]
[Use of protease 3c and foot-and-mouth disease virus RNA polymerase hybrid proteins, synthesized in Escherichia coli, for diagnosis]
Fowlpox
Reverse Genetics System for the Avian Coronavirus Infectious Bronchitis Virus.
Fragile X Syndrome
A Drosophila model of Fragile X syndrome exhibits defects in phagocytosis by innate immune cells.
A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies.
A metabolomic and systems biology perspective on the brain of the fragile X syndrome mouse model.
A mouse model of the human Fragile X syndrome I304N mutation.
A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability.
A novel function for fragile X mental retardation protein in translational activation.
A novel role of fragile X mental retardation protein in pre-mRNA alternative splicing through RNA-binding protein 14.
A nuclear role for the Fragile X mental retardation protein.
Advances in understanding of fragile X pathogenesis and FMRP function, and in identification of X linked mental retardation genes.
Analysis of FMRP mRNA target datasets reveals highly associated mRNAs mediated by G-quadruplex structures formed via clustered WGGA sequences.
Broadening Roles for FMRP: Big News for Big Potassium (BK) Channels.
Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis.
Delayed stabilization of dendritic spines in fragile X mice.
Dissecting FMR1, the protein responsible for fragile X syndrome, in its structural and functional domains.
Dysregulation and restoration of translational homeostasis in fragile X syndrome.
FMRP interferes with the Rac1 pathway and controls actin cytoskeleton dynamics in murine fibroblasts.
FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A.
FMRP regulates miR196a-mediated repression of HOXB8 via interaction with the AGO2 MID domain.
FMRP regulates the transition from radial glial cells to intermediate progenitor cells during neocortical development.
Fragile mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes.
Fragile X mental retardation protein (FMRP) and metabotropic glutamate receptor subtype 5 (mGlu5) control stress granule formation in astrocytes.
Fragile X mental retardation protein (FMRP) binds specifically to the brain cytoplasmic RNAs BC1/BC200 via a novel RNA-binding motif.
Fragile X mental retardation protein (FMRP) interacting proteins exhibit different expression patterns during development.
Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack.
Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors.
Fragile X mental retardation protein induces synapse loss through acute postsynaptic translational regulation.
Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2.
Fragile X mental retardation protein regulates accumulation of the active zone protein Munc18-1 in presynapses via local translation in axons during synaptogenesis.
Fragile X mental retardation protein shifts between polyribosomes and stress granules after neuronal injury by arsenite stress or in vivo hippocampal electrode insertion.
Fragile X protein controls neural stem cell proliferation in the Drosophila brain.
Fragile X Syndrome: From molecular pathology to therapy.
Glutamate Induces the Elongation of Early Dendritic Protrusions via mGluRs in Wild Type Mice, but Not in Fragile X Mice.
Heads-up: New roles for the fragile X mental retardation protein in neural stem and progenitor cells.
HITS-CLIP in various brain areas reveals new targets and new modalities of RNA binding by fragile X mental retardation protein.
Involvement of FMRP in Primary MicroRNA Processing via Enhancing Drosha Translation.
Lost once, the Fragile X Mental Retardation protein is now back onto brain polyribosomes.
Metabotropic glutamate receptors and fragile x mental retardation protein: partners in translational regulation at the synapse.
Modulation of dendritic spines and synaptic function by Rac1: a possible link to Fragile X syndrome pathology.
Neuronal activity drives FMRP- and HSPG-dependent matrix metalloproteinase function required for rapid synaptogenesis.
New Insights Into the Role of Cav2 Protein Family in Calcium Flux Deregulation in Fmr1-KO Neurons.
On BC1 RNA and the fragile X mental retardation protein.
Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting.
Persistent astrocyte activation in the fragile X mouse cerebellum.
Quantitative profiling of brain lipid raft proteome in a mouse model of fragile X syndrome.
Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice.
RNA and microRNAs in fragile X mental retardation.
Roles of fragile X mental retardation protein in dopaminergic stimulation-induced synapse-associated protein synthesis and subsequent alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) receptor internalization.
S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade.
Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex.
Splicing of exon 9a in FMR1 transcripts results in a truncated FMRP with altered subcellular distribution.
Targeting the endocannabinoid system in the treatment of fragile X syndrome.
The FMRP/GRK4 mRNA interaction uncovers a new mode of binding of the Fragile X mental retardation protein in cerebellum.
The fragile X mental retardation protein FMRP binds elongation factor 1A mRNA and negatively regulates its translation in vivo.
The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules.
Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression.
Understanding fragile X syndrome: insights from animal models.
Widespread Alterations in Translation Elongation in the Brain of Juvenile Fmr1 Knockout Mice.
[Fragile X syndrome, a disease caused by defects in an RNA-binding protein]
Frontotemporal Dementia
A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons.
A matter of balance.
Abnormal RNA stability in amyotrophic lateral sclerosis.
Detection of TAR DNA-binding protein 43 (TDP-43) oligomers as initial intermediate species during aggregate formation.
Ectopic expression of Musashi-1 in Alzheimer disease and Pick disease.
Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching.
Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation.
FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons.
FUS contributes to mTOR-dependent inhibition of translation.
Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function.
Inter-Species Differences in Regulation of the Progranulin-Sortilin Axis in TDP-43 Cell Models of Neurodegeneration.
Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two Distinct Types of ALS/FTD-Linked FUS Mutations.
Lysine acetylation regulates the RNA binding, subcellular localization and inclusion formation of FUS.
Mechanisms of TDP-43 Proteinopathy Onset and Propagation.
Molecular structure and interactions within amyloid-like fibrils formed by a low-complexity protein sequence from FUS.
Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity.
Quantitative analysis of cryptic splicing associated with TDP-43 depletion.
Specific aromatic foldamers potently inhibit spontaneous and seeded A?42 and A?43 fibril assembly.
Split GFP technologies to structurally characterize and quantify functional biomolecular interactions of FTD-related proteins.
SUMOylation Regulates TDP-43 Splicing Activity and Nucleocytoplasmic Distribution.
TDP-43 and NOVA-1 RNA-binding proteins as competitive splicing regulators of the schizophrenia-associated TNIK gene.
The FTD/ALS-associated RNA-binding protein TDP-43 regulates the robustness of neuronal specification through microRNA-9a in Drosophila.
The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients.
Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.
Frontotemporal Lobar Degeneration
3'UTR Length-Dependent Control of SynGAP Isoform ?2 mRNA by FUS and ELAV-like Proteins Promotes Dendritic Spine Maturation and Cognitive Function.
Activity-dependent FUS dysregulation disrupts synaptic homeostasis.
Biological Spectrum of Amyotrophic Lateral Sclerosis Prions.
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.
FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved introns.
FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis.
Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity.
Neuron-to-Neuron Transfer of FUS in Drosophila Primary Neuronal Culture Is Enhanced by ALS-Associated Mutations.
RBM45 homo-oligomerization mediates association with ALS-linked proteins and stress granules.
Severe respiratory changes at end stage in a FUS-induced disease state in adult rats.
TBPH/TDP-43 modulates translation of Drosophila futsch mRNA through an UG-rich sequence within its 5'UTR.
TDP-43 accelerates deadenylation of target mRNAs by recruiting Caf1 deadenylase.
TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration.
TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor.
The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation.
The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients.
The role of FUS gene variants in neurodegenerative diseases.
Transposable Elements in TDP-43-Mediated Neurodegenerative Disorders.
Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration.
[Pathomechanisms and clinical aspects of frontotemporal lobar degeneration].
Ganglioglioma
The reelin pathway components disabled-1 and p35 in gangliogliomas--a mutation and expression analysis.
Gastroenteritis
Application of Molecular Dynamics Simulations to the Design of Nucleotide Inhibitors Binding to Norovirus Polymerase.
Comparative in vivo analysis of the nsp15 endoribonuclease of murine, porcine and severe acute respiratory syndrome coronaviruses.
Complete genomic sequences, a key residue in the spike protein and deletions in nonstructural protein 3b of US strains of the virulent and attenuated coronaviruses, transmissible gastroenteritis virus and porcine respiratory coronavirus.
Crystallographic and Biochemical Analysis of Rotavirus NSP2 with Nucleotides Reveals a Nucleoside Diphosphate Kinase-Like Activity.
Design and construction of African swine fever virus chimeras incorporating foreign viral epitopes.
Detection of the norovirus variants GGII.4 hunter and GGIIb/hilversum in Italian children with gastroenteritis.
Effective inhibition of porcine transmissible gastroenteritis virus replication in ST cells by shRNAs targeting RNA-dependent RNA polymerase gene.
Emergence of unique variants and inter-genotype recombinants of human astroviruses infecting infants, children and adults in Kolkata, India.
Etiology of sporadic cases of pediatric acute gastroenteritis in asturias, Spain, and genotyping and characterization of norovirus strains involved.
Gastroenteritis outbreaks associated with Norwalk-like viruses and their investigation by nested RT-PCR.
Genetic polymorphism across regions of the three open reading frames of "Norwalk-like viruses".
Human enteric Caliciviridae: a new prevalent small round-structured virus group defined by RNA-dependent RNA polymerase and capsid diversity.
Immunogenic characterization and epitope mapping of transmissible gastroenteritis virus RNA dependent RNA polymerase.
Insight Into the Interaction Between RNA Polymerase and VPg for Murine Norovirus Replication.
Molecular characterisation of small round structured viruses associated with gastroenteritis in South Africa.
Molecular characterization of partial-open reading frames 1a and 2 of the human astroviruses in South Korea.
Molecular epidemiology of caliciviruses causing outbreaks and sporadic cases of acute gastroenteritis in Spain.
Norovirus RNA-dependent RNA polymerase: A computational study of metal-binding preferences.
Norovirus RNA-dependent RNA-polymerase is phosphorylated by an important survival kinase, Akt.
Porcine transmissible gastroenteritis virus nonstructural protein 2 contributes to inflammation via NF-?B activation.
Putative E3 ubiquitin ligase of human rotavirus inhibits NF-?B activation by using molecular mimicry to target ?-TrCP.
RNA polymerase associated with human rotaviruses in diarrhea stools.
Shutdown of interferon signaling by a viral-hijacked E3 ubiquitin ligase.
Transmissible gastroenteritis coronavirus RNA-dependent RNA polymerase and nonstructural proteins 2, 3, and 8 are incorporated into viral particles.
Viral shedding in gastroenteritis in children caused by variants and novel recombinant norovirus infections.
[Rapid and efficient detection method of Norwalk virus]
Gastroenteritis, Transmissible, of Swine
Effective inhibition of porcine transmissible gastroenteritis virus replication in ST cells by shRNAs targeting RNA-dependent RNA polymerase gene.
Gastroesophageal Reflux
Analysis of transcriptional control of the gerD spore germination gene of Bacillus subtilis 168.
Gastrointestinal Stromal Tumors
High expression of the RNA-binding protein RBPMS2 in gastrointestinal stromal tumors.
Genetic Diseases, Inborn
Mapping the Transcriptome-Wide Landscape of RBP Binding Sites Using gPAR-CLIP-seq: Bioinformatic Analysis.
The genetic control of protein synthesis: The haemoglobin model.
Glaucoma
The RNA-binding protein and stress granule component ATAXIN-2 is expressed in mouse and human tissues associated with glaucoma pathogenesis.
Glioblastoma
Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development.
Anti-cancer effects of the HuR inhibitor, MS-444, in malignant glioma cells.
Eribulin penetrates brain tumor tissue and prolongs survival of mice harboring intracerebral glioblastoma xenografts.
MSI2-TGF-?/TGF-? R1/SMAD3 positive feedback regulation in glioblastoma.
Musashi1 Impacts Radio-Resistance in Glioblastoma by Controlling DNA-Protein Kinase Catalytic Subunit.
RNA-Binding Protein Musashi1 Is a Central Regulator of Adhesion Pathways in Glioblastoma.
The oncogenic RNA-binding protein Musashi1 is regulated by HuR via mRNA translation and stability in glioblastoma cells.
The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation.
UPF1 regulates the malignant biological behaviors of glioblastoma cells via enhancing the stability of Linc-00313.
Glioma
A Novel Signature Constructed by RNA-Binding Protein Coding Genes to Improve Overall Survival Prediction of Glioma Patients.
ANOVA, a putative astrocytic RNA-binding protein gene that maps to chromosome 19q13.3.
Augmented therapeutic efficacy of an oncolytic herpes simplex virus type 1 mutant expressing ICP34.5 under the transcriptional control of musashi1 promoter in the treatment of malignant glioma.
C/EBP? mediates RNA polymerase III-driven transcription of oncomiR-138 in malignant gliomas.
CIRP regulates BEV-induced cell migration in gliomas.
Exosomes derived from microRNA-199a-overexpressing mesenchymal stem cells inhibit glioma progression by down-regulating AGAP2.
Expression of Progesterone Receptor Membrane Component 1 (PGRMC1), Progestin and AdipoQ Receptor 7 (PAQPR7), and Plasminogen Activator Inhibitor 1 RNA-Binding Protein (PAIRBP1) in Glioma Spheroids In Vitro.
Expression of the neural RNA-binding protein Musashi1 in human gliomas.
Hu Antigen R (HuR) multimerization contributes to glioma disease progression.
Identification of RNA-binding protein LARP4B as a tumor suppressor in glioma.
Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion.
Lin28A promotes IRF6-regulated aerobic glycolysis in glioma cells by stabilizing SNHG14.
Musashi1 enhances chemotherapy resistance of pediatric glioblastoma cells in vitro.
Musashi1, an evolutionarily conserved neural RNA-binding protein, is a versatile marker of human glioma cells in determining their cellular origin, malignancy, and proliferative activity.
Persistent infection of a temperature-sensitive G31 vesicular stomatitis virus mutant in neural and nonneural cells: biological and virological characteristics.
Prognostic value of Musashi-1 in gliomas.
RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways.
RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3.
RNA-binding Protein UNR Promotes Glioma Cell Migration and Regulates the Expression of Ribosomal Protein L9.
Splicing factors PTBP1 and PTBP2 promote proliferation and migration of glioma cell lines.
The histone deacetylase SIRT6 suppresses the expression of the RNA-binding protein PCBP2 in glioma.
The RNA-binding protein HuR promotes glioma growth and treatment resistance.
The RNA-binding protein SRSF1 is a key cell cycle regulator via stabilizing NEAT1 in glioma.
Zika virus NS5 protein inhibits cell growth and invasion of glioma.
Gonadal Dysgenesis
WT1 and kidney progenitor cells.
Granuloma
THE EFFECT OF STEM CELLS AS AN ADJUVANT ON THE IMMUNOGENICITY OF A POTENTIAL ANTI-SCHISTOSOMAL VACCINE IN MICE.
Hand, Foot and Mouth Disease
Expression of enterovirus 71 capsid protein VP1 in Escherichia coli and its clinical application.
GITRL as a genetic adjuvant enhances enterovirus 71 VP1 DNA vaccine immunogenicity.
Head and Neck Neoplasms
RNA-Binding Protein La Mediates TGF?-Induced Epithelial to Mesenchymal Transition and Cancer Stem Cell Properties.
Heart Arrest
The Value of Extracellular Cold-Inducible RNA-Binding Protein (eCIRP) in Predicting the Severity and Prognosis of Patients After Cardiac Arrest: A Preliminary Observational Study.
Therapeutic Hypothermia Enhances Cold-Inducible RNA-Binding Protein Expression and Inhibits Mitochondrial Apoptosis in a Rat Model of Cardiac Arrest.
Heart Diseases
Increased Cardiac Arrhythmogenesis Associated With Gap Junction Remodeling With Upregulation of RNA-Binding Protein FXR1.
Heart Failure
CELF1 promotes vascular endothelial growth factor degradation resulting in impaired microvasculature in heart failure.
Rbm20-deficient cardiogenesis reveals early disruption of RNA processing and sarcomere remodeling establishing a developmental etiology for dilated cardiomyopathy.
RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.
Titin Forms Circles: Regulation by Heart Failure and the RNA-Binding Protein RBM20.
Hematologic Diseases
Enhancement of LIN28B-induced hematopoietic reprogramming by IGF2BP3.
Hematologic Neoplasms
Che-1 is targeted by c-Myc to sustain proliferation in pre-B-cell acute lymphoblastic leukemia.
Hemophilia A
Hepatitis C virus infection in children with hemophilia: characterization of antibody response to four different antigens and relationship of antibody response, viremia, and hepatic dysfunction.
Hemorrhagic Fever with Renal Syndrome
Primary structure of the large (L) RNA segment of nephropathia epidemica virus strain Hällnäs B1 coding for the viral RNA polymerase.
Hemorrhagic Fever, Crimean
Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease.
Crimean-Congo hemorrhagic fever virus-encoded ovarian tumor (OTU) protease activity is dispensable for virus RNA polymerase function.
In silico structural elucidation of RNA-dependent RNA polymerase towards the identification of potential Crimean-Congo Hemorrhagic Fever Virus inhibitors.
Next-generation sequencing of southern African Crimean-Congo haemorrhagic fever virus isolates reveals a high frequency of M segment reassortment.
Hemorrhagic Fever, Ebola
Ribavirin does not potentiate favipiravir antiviral activity against Ebola virus in non-human primates.
Hemorrhagic Septicemia
Virion RNA polymerases of two salmonid rhabdoviruses.
Hemorrhagic Septicemia, Viral
A single amino acid mutation (I1012F) of the RNA polymerase of marine viral hemorrhagic septicemia virus changes the in vitro virulence to rainbow trout gill epithelial cells.
Expression profiling, immune functions, and molecular characteristics of the tetraspanin molecule CD63 from Amphiprion clarkii.
Hepatitis
(1)H, (13)C, (15)N resonance assignments of murine hepatitis virus nonstructural protein 3a.
Analysis of hepatitis A virus protein 2B in sera of hepatitis A of various severities.
Aquarius, a novel gene isolated by gene trapping with an RNA-dependent RNA polymerase motif.
B lymphocyte and macrophage expression of carcinoembryonic antigen-related adhesion molecules that serve as receptors for murine coronavirus.
Bovine Coronavirus nsp1 (p28) is an RNA Binding Protein that Binds Terminal Genomic Cis-Replication Elements.
Characterization by mass spectrometry of a recombinant hepatitis delta virus antigen and its proteolytic products.
Characterization of monoclonal antibodies against duck hepatitis type 1 virus VP1 protein.
Characterization of the expression, intracellular localization, and replication complex association of the putative mouse hepatitis virus RNA-dependent RNA polymerase.
Characterization of the phosphorylated forms and the phosphorylated residues of hepatitis delta virus delta antigens.
Characterization of two RNA polymerase activities induced by mouse hepatitis virus.
Comparative in vivo analysis of the nsp15 endoribonuclease of murine, porcine and severe acute respiratory syndrome coronaviruses.
Comparison of genomic and predicted amino acid sequences of respiratory and enteric bovine coronaviruses isolated from the same animal with fatal shipping pneumonia.
Complete sequence (20 kilobases) of the polyprotein-encoding gene 1 of transmissible gastroenteritis virus.
Crystallization and structure determination of a hepatitis delta virus ribozyme: use of the RNA-binding protein U1A as a crystallization module.
Development of an improved dual-promoter-based reverse genetics system for emerging Senecavirus A.
Direct investigation of protein RNA-binding domains using digoxigenin-labelled RNAs and synthetic peptides: application to the hepatitis delta antigen.
Dissection of amino-terminal functional domains of murine coronavirus nonstructural protein 3.
Dynamics of coronavirus replication-transcription complexes.
Emerging antiviral drugs.
Evaluation of hepatitis delta virus RNA levels during interferon therapy by analysis of polymerase chain reaction products with a nonradioisotopic hybridization assay.
Follow-up study of anti-hepatitis C virus antibodies in blood donors implicated in post-transfusion non-A, non-B hepatitis.
Further characterization of mouse hepatitis virus RNA-dependent RNA polymerases.
HCV RNA-dependent RNA polymerase replicates in vitro the 3' terminal region of the minus-strand viral RNA more efficiently than the 3' terminal region of the plus RNA.
Hepatitis C virus of subtype 2l in marseille, southeastern france.
Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens.
Host RNA polymerase requirements for transcription of the human hepatitis delta virus genome.
Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.
Identification and analysis of MHV-A59 P28 cleavage site.
Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins.
Identification and stability of a 30-kDa nonstructural protein encoded by mRNA 2 of mouse hepatitis virus in infected cells.
Identification of mouse hepatitis virus papain-like proteinase 2 activity.
Identification of putative polymerase gene product in cells infected with murine coronavirus A59.
Identification of the murine coronavirus p28 cleavage site.
Immune response to a hepatitis C virus nonstructural protein in chronic hepatitis C virus infection.
Improvement of hepatitis C virus RNA polymerase chain reaction through a multicentre quality control study. French Study Group for the Standardization of Hepatitis C Virus PCR.
In situ enzymatic oligonucleotide amplification of hepatitis C virus-RNA in liver biopsy specimens (reverse transcriptase in situ polymerase chain reaction) after orthotopic liver transplantation for hepatitis C-related liver disease.
Maturation of the polymerase polyprotein of the coronavirus MHV strain JHM involves a cascade of proteolytic processing events.
Mobility and interactions of the coronavirus nonstructural protein 4.
Mouse hepatitis virus strain A59 RNA polymerase gene ORF 1a: heterogeneity among MHV strains.
Murine coronaviruses encoding nsp2 at different genomic loci have altered replication, protein expression, and localization.
New antiviral target revealed by the hexameric structure of mouse hepatitis virus nonstructural protein nsp15.
Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase.
Nucleotide sequence of the human coronavirus 229E RNA polymerase locus.
Organ-specific attenuation of murine hepatitis virus strain A59 by replacement of catalytic residues in the putative viral cyclic phosphodiesterase ns2.
Processing of the coronavirus MHV-JHM polymerase polyprotein: identification of precursors and proteolytic products spanning 400 kilodaltons of ORF1a.
Protection against yellow fever in monkeys by immunization with yellow fever virus nonstructural protein NS1.
Protein-Encoding RNA to RNA Information Transfer in Mammalian Cells: RNA-dependent mRNA Amplification. Identification of Chimeric RNA Intermediates and Putative RNA End Products.
Recombinant VP1 protein of duck hepatitis virus 1 expressed in Pichia pastoris and its immunogenicity in ducks.
Rescue of tomato spotted wilt virus entirely from complementary DNA clones.
RNA replication without RNA-dependent RNA polymerase: surprises from hepatitis delta virus.
RNA-binding activity of hepatitis delta antigen involves two arginine-rich motifs and is required for hepatitis delta virus RNA replication.
RNA-dependent Amplification of Mammalian mRNA Encoding Extracellullar Matrix Proteins: Identification of Chimeric RNA Intermediates for ?1, ?1, and ?1 Chains of Laminin.
RNA-templated replication of hepatitis delta virus: genomic and antigenomic RNAs associate with different nuclear bodies.
Search for antisense copies of beta-globin mRNA in anemic mouse spleen.
Sequence and expression analysis of potential nonstructural proteins of 4.9, 4.8, 12.7, and 9.5 kDa encoded between the spike and membrane protein genes of the bovine coronavirus.
Serodiagnosis of hepatitis C virus (HCV) infection with an HCV core protein molecularly expressed by a recombinant baculovirus.
Stable expression of hepatitis delta virus antigen in a eukaryotic cell line.
Synthesis of virus-specific RNA in permeabilized murine coronavirus-infected cells.
The complete sequence (22 kilobases) of murine coronavirus gene 1 encoding the putative proteases and RNA polymerase.
The fitness of defective interfering murine coronavirus DI-a and its derivatives is decreased by nonsense and frameshift mutations.
The Interaction between the RNA-Dependent RNA-Polymerase of the Hepatitis Virus and RNA Matrices.
Tissue hepatitis C virus RNA quantification and protein expression help identify early hepatitis C virus recurrence after liver transplantation.
Translation and processing of mouse hepatitis virus virion RNA in a cell-free system.
Use and interpretation of HCV diagnostic tests in the clinical setting.
Viral replication. Structural basis for RNA replication by the hepatitis C virus polymerase.
Viroids: self-replicating, mobile, and fast-evolving noncoding regulatory RNAs.
Whole-genome analysis of genetic recombination of hepatitis delta virus: molecular domain in delta antigen determining trans-activating efficiency.
[A clinical analysis of twelve patients with Galerina autumnalis poisoning]
[Expression of VP1 gene and ELISA detection of antibodies against duck hepatitis virus]
[Viral hepatitis B und C.]
Hepatitis A
A comparative volatilomic characterization of Florence fennel from different locations: antiviral prospects.
Acute hepatitis A virus infection in Turkey.
Altered hepatitis A VP1 protein resulting from cell culture propagation of virus.
Analysis of hepatitis A virus protein 2B in sera of hepatitis A of various severities.
Competitor template RNA for detection and quantitation of hepatitis A virus by PCR.
Detection of hepatitis A virus RNA and capsid antigen in individual cells.
Determinants in 3Dpol modulate the rate of growth of hepatitis A virus.
Development and evaluation of an indirect ELISA based on recombinant nonstructural protein 3A to detect antibodies to duck hepatitis A virus type 1.
Hepatitis E virus-associated aplastic anaemia: the first case of its kind.
High yield expression of duck hepatitis A virus VP1 protein in Escherichia coli, and production and characterization of polyclonal antibody.
Identification of a Conserved B-Cell Epitope on Duck Hepatitis A Type 1 Virus VP1 Protein.
Importance of amino acid 216 in nonstructural protein 2B for replication of hepatitis A virus in cell culture and in vivo.
Internal initiation sites of de novo RNA synthesis within the hepatitis C virus polypyrimidine tract.
Molecular evolution of hepatitis A virus: a new classification based on the complete VP1 protein.
Oral vaccine of recombinant Lactococcus lactis expressing the VP1 protein of duck hepatitis A virus type 3 induces mucosal and systemic immune responses.
Production of infectious hepatitis C virus by using RNA polymerase I-mediated transcription.
Recombinant VP1 protein as a potential marker for the diagnosis of acute hepatitis A virus infection.
Sequence analysis of hepatitis A virus cDNA coding for capsid proteins and RNA polymerase.
Signals in hepatitis A virus P3 region proteins recognized by the ubiquitin-mediated proteolytic system.
The 3D protein of duck hepatitis A virus type 1 binds to a viral genomic 3' UTR and shows RNA-dependent RNA polymerase activity.
Variations in genome fragments coding for RNA polymerase in human and simian hepatitis A viruses.
[A model of the secondary structure and distribution of antigenic determinants in the VP1 protein of hepatitis A virus]
Hepatitis B
A sensitive procedure for mapping the boundaries of RNA elements binding in vitro translated proteins defines a minimal hepatitis B virus encapsidation signal.
Approved Antiviral Drugs over the Past 50 Years.
cDNA encoding a chicken protein (CRP1) with homology to hnRNP type A/B.
Chimeric hepatitis B virus core particles as probes for studying peptide-integrin interactions.
Cluster of differentiation 4+ T-cell counts and human immunodeficiency virus-1 viral load in patients coinfected with hepatitis B virus and hepatitis C virus.
Complete nucleotide sequence of the nucleoprotein gene from the human influenza strain A/PR/8/34 (HON1).
Critical role of the 36-nucleotide insertion in hepatitis B virus genotype G in core protein expression, genome replication, and virion secretion.
Effect of mutation in the hepatitis C virus nonstructural 5B region on HCV replication.
Emerging antiviral drugs.
Entecavir treatment may be associated with decreased libido in male patients with chronic hepatitis B: report of two cases.
Functional characterization of the interaction between human La and hepatitis B virus RNA.
HBx protein of hepatitis B virus interacts with the C-terminal portion of a novel human proteasome alpha-subunit.
Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production.
Hepatitis B virus X protein induces RNA polymerase III-dependent gene transcription and increases cellular TATA-binding protein by activating the Ras signaling pathway.
Hepatitis B virus X protein promotes interleukin-7 receptor expression via NF-?B and Notch1 pathway to facilitate proliferation and migration of hepatitis B virus-related hepatoma cells.
Hepatitis G virus infection in patients with hepatocellular carcinoma in Recife, Brazil.
Incorporation of deoxyribonucleotides and ribonucleotides by a dNTP-binding cleft mutated reverse transcriptase in hepatitis B virus core particles.
Inhibition of duck hepatitis B virus replication by 2',3'-dideoxycytidine. A potent inhibitor of reverse transcriptase.
On the early emergence of reverse transcription: theoretical basis and experimental evidence.
Phosphorylation of human La protein at Ser 366 by casein kinase II contributes to hepatitis B virus replication and expression in vitro.
Proteolytic processing of the hepatitis B virus e antigen precursor. Cleavage at two furin consensus sequences.
RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts.
Regulation of RNA polymerase I-dependent promoters by the hepatitis B virus X protein via activated Ras and TATA-binding protein.
Specific interactions between human integrin alpha v beta 3 and chimeric hepatitis B virus core particles bearing the receptor-binding epitope of foot-and-mouth disease virus.
The impact of hepatitis C virus viremia on renal graft and patient survival: a 9-year prospective study.
The Long-Term Effect of Hepatitis C Virus on the Outcome of Live-Donor Kidney Transplant Recipients. A Retrospective Study.
Hepatitis B, Chronic
Factors Contributing to the Antiviral Effectiveness of Tenofovir.
Hepatitis C
"Inapparent" hepatitis B virus infection and hepatitis C virus replication in alcoholic subjects with and without liver disease.
1,5-Benzodiazepine inhibitors of HCV NS5B polymerase.
1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors.
12 Weeks of a Ribavirin-Free Sofosbuvir and Nonstructural Protein 5A Inhibitor Regimen Is Enough to Treat Recurrence of Hepatitis C After Liver Transplantation.
178 Dual allosteric inhibitors jointly modulate structure and dynamics in the Hepatitis C Virus polymerase.
1a/1b subtype profiling of nonnucleoside polymerase inhibitors of hepatitis C virus.
2'-Deoxy-2'-spirocyclopropylcytidine Revisited: A New and Selective Inhibitor of the Hepatitis C Virus NS5B Polymerase.
2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups.
2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis.
2-(3-Thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acids as inhibitors of HCV NS5B RdRp.
2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase.
2-Hydroxy-1-oxo-1,2-dihydroisoquinoline-3-carboxylic acid with Inbuilt ?-N-hydroxy-?-keto-acid pharmacophore as HCV NS5B polymerase inhibitors.
2D and 3D quantitative structure-activity relationship study of hepatitis C virus NS5B polymerase inhibitors by comparative molecular field analysis and comparative molecular similarity indices analysis methods.
3'-Deoxy phosphoramidate dinucleosides as improved inhibitors of hepatitis C virus subgenomic replicon and NS5B polymerase activity.
3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
3D Molecular Modelling Study of the H7N9 RNA-Dependent RNA Polymerase as an Emerging Pharmacological Target.
3D QSAR and molecular docking studies of benzimidazole derivatives as hepatitis C virus NS5B polymerase inhibitors.
4-Thiazolidinones: a novel class of hepatitis C virus NS5B polymerase inhibitors.
A cell-based reporter assay for inhibitor screening of hepatitis C virus RNA-dependent RNA polymerase.
A cell-permeable hairpin peptide inhibits hepatitis C viral nonstructural protein 5A-mediated translation and virus production.
A cellular RNA-binding protein enhances internal ribosomal entry site-dependent translation through an interaction downstream of the hepatitis C virus polyprotein initiation codon.
A cis-acting replication element in the sequence encoding the NS5B RNA-dependent RNA polymerase is required for hepatitis C virus RNA replication.
A Complex Network of Interactions between S282 and G283 of Hepatitis C Virus Nonstructural Protein 5B and the Template Strand Affects Susceptibility to Sofosbuvir and Ribavirin.
A Conserved Tandem Cyclophilin-Binding Site in Hepatitis C Virus Nonstructural Protein 5A Regulates Alisporivir Susceptibility.
A continuous nonradioactive assay for RNA-dependent RNA polymerase activity.
A Cyclic Phosphoramidate Prodrug of 2'-deoxy-2'-fluoro-2'-C-methylguanosine for the Treatment of Dengue Infection.
A fluorescence-based high-throughput screen to identify small compound inhibitors of the genotype 3a hepatitis C virus RNA polymerase.
A hepatitis C virus-encoded, nonstructural protein (NS3) triggers dysfunction and apoptosis in lymphocytes: role of NADPH oxidase-derived oxygen radicals.
A highly efficient, asymmetric synthesis of benzothiadiazine-substituted tetramic acids: potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
A homogeneous, solid-phase assay for hepatitis C virus RNA-dependent RNA polymerase.
A locking mechanism regulates RNA synthesis and host protein interaction by the hepatitis C virus polymerase.
A mini-review on sofosbuvir and daclatasvir treatment in coronavirus disease 2019.
A nonisotopic assay method for hepatitis C virus NS5B polymerase.
A Novel Class of Highly Potent Irreversible Hepatitis C Virus NS5B Polymerase Inhibitors.
A novel hepatitis C virus NS5B polymerase assay of de novo initiated RNA synthesis directed from a heteropolymeric RNA template.
A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase.
A Novel Promising Therapeutic Option Against Hepatitis C Virus: An Oral Nucleotide NS5B Polymerase Inhibitor Sofosbuvir.
A novel recombinant single-chain hepatitis C virus NS3-NS4A protein with improved helicase activity.
A Proline-Tryptophan Turn in the Intrinsically Disordered Domain 2 of NS5A Protein Is Essential for Hepatitis C Virus RNA Replication.
A quantitative high-resolution genetic profile rapidly identifies sequence determinants of hepatitis C viral fitness and drug sensitivity.
A recombinant hepatitis C virus RNA-dependent RNA polymerase capable of copying the full-length viral RNA.
A relaxed discrimination of 2'-O-methyl-GTP relative to GTP between de novo and Elongative RNA synthesis by the hepatitis C RNA-dependent RNA polymerase NS5B.
A replicon-based shuttle vector system for assessing the phenotype of HCV NS5B polymerase genes isolated from patient populations.
A retrospective case-control study of hepatitis C virus infection and oral lichen planus in Japan: association study with mutations in the core and NS5A region of hepatitis C virus.
A review on an update of NS5B polymerase hepatitis C virus inhibitors.
A screen for novel hepatitis C virus RdRp inhibitor identifies a broad-spectrum antiviral compound.
A search for hepatitis C virus polymerase chain reaction-positive but seronegative subjects among blood donors with elevated alanine aminotransferase.
A simple, effective approach for rapid development of high-throughput and reliable LC-MS/MS bioanalytical assays.
A single-amino-acid mutation in hepatitis C virus NS5A disrupting FKBP8 interaction impairs viral replication.
A time-resolved, internally quenched fluorescence assay to characterize inhibition of hepatitis C virus nonstructural protein 3-4A protease at low enzyme concentrations.
A validated LC-MS/MS method for the simultaneous determination of BMS-791325, a hepatitis C virus NS5B RNA polymerase inhibitor, and its metabolite in plasma.
Activation of protein kinase R by hepatitis C virus RNA-dependent RNA polymerase.
Activation of RNA polymerase I transcription by hepatitis C virus core protein.
Active site inhibitors of HCV NS5B polymerase. The development and pharmacophore of 2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid.
Activity of a potent hepatitis C virus polymerase inhibitor in the chimpanzee model.
Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells.
Addition of ribavirin to daclatasvir plus asunaprevir for chronic hepatitis C 1b patients with baseline NS5A resistance-associated variants improved response.
Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus.
All three domains of the hepatitis C virus nonstructural NS5A protein contribute to RNA binding.
Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly.
Allosteric inhibition of the hepatitis C virus NS5B polymerase: in silico strategies for drug discovery and development.
Allosteric inhibition of the hepatitis C virus NS5B RNA dependent RNA polymerase.
Allosteric inhibitors have distinct effects, but also common modes of action, in the HCV polymerase.
Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: structure-based design and synthesis of new templates.
Allosteric mechanism of cyclopropylindolobenzazepine inhibitors for HCV NS5B RdRp via dynamic correlation network analysis.
Amino Acid Substitutions in Genotype 3a Hepatitis C Virus Polymerase Protein Affect Responses to Sofosbuvir.
Amplification and sequencing of the hepatitis C virus NS3/4A protease and the NS5B polymerase regions for genotypic resistance detection of clinical isolates of subtypes 1a and 1b.
An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A.
An efficient colorimetric assay for RNA synthesis by viral RNA-dependent RNA polymerases, using thermostable pyrophosphatase.
An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
An in vitro coupled transcription/translation reporter system for hepatitis C virus RNA-dependent RNA polymerase.
An Integrative Drug Repurposing Pipeline: Switching Viral Drugs to Breast Cancer.
An interferon lambda 4-associated variant in the hepatitis C virus RNA polymerase affects viral replication in infected cells.
An objective assessment of conformational variability in complexes of hepatitis C virus polymerase with non-nucleoside inhibitors.
An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication.
Analysis of drug-resistance-associated mutations and genetic barriers in hepatitis C virus NS5B sequences in China.
Analysis of Naturally Occurring Resistance-Associated Variants to NS3/4A Protein Inhibitors, NS5A Protein Inhibitors, and NS5B Polymerase Inhibitors in Patients With Chronic Hepatitis C.
Analysis of the Resistance of Hepatitis C Virus NS5B Polymerase Inhibitors via Docking and Molecular Dynamics Simulation.
Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs.
Antigenic heterogeneity of the hepatitis C virus NS5A protein.
Antiviral activity and mode of action of TMC647078, a novel nucleoside inhibitor of the hepatitis C virus NS5B polymerase.
Antiviral Activity of Substituted Salicylanilides - A Review.
Antiviral activity of the hepatitis C virus polymerase inhibitor filibuvir in genotype 1-infected patients.
Antiviral Activity, Safety, and Tolerability of Multiple Ascending Doses of Elbasvir or Grazoprevir in Participants Infected With Hepatitis C Virus Genotype-1 or -3.
Antiviral effect of human recombinant interleukin-12 in patients infected with hepatitis C virus.
Antiviral Effect, Safety, and Pharmacokinetics of Five-Day Oral Administration of Deleobuvir (BI 207127), an Investigational Hepatitis C Virus RNA Polymerase Inhibitor, in Patients with Chronic Hepatitis C.
Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein.
Antiviral suppression vs restoration of RIG-I signaling by hepatitis C protease and polymerase inhibitors.
Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles.
Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase.
Approved Antiviral Drugs over the Past 50 Years.
Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives.
Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif.
Assembly, purification and pre-steady-state kinetic analysis of an active RNA-dependent RNA polymerase elongation complex.
Assessment of hepatitis C virus RNA levels by quantitative competitive RNA polymerase chain reaction: high-titer viremia correlates with advanced stage of disease.
Association between interleukin 28B polymorphism and sustained virological response to sofosbuvir plus daclatasvir in chronic hepatitis C genotype 4 Egyptian patients.
Association of amino acid substitution pattern in nonstructural protein 5A of hepatitis C virus genotype2a low viral load and response to interferon monotherapy.
Asunaprevir plus daclatasvir for the treatment of chronic hepatitis C virus infection.
Autoantibodies and Autoimmune Disease During Treatment of Children With Chronic Hepatitis C.
Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infection.
B-ring modified aurones as promising allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
Back-priming mode of phi6 RNA-dependent RNA polymerase.
Bacteriophage phi 6 RNA-dependent RNA polymerase: molecular details of initiating nucleic acid synthesis without primer.
Balapiravir plus peginterferon alfa-2a (40KD)/ribavirin in a randomized trial of hepatitis C genotype 1 patients.
Baseline Polymorphisms and Emergence of Drug Resistance in the NS3/4A Protease of Hepatitis C Virus Genotype 1 following Treatment with Faldaprevir and Pegylated Interferon Alpha 2a/Ribavirin in Phase 2 and Phase 3 Studies.
Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109.
Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: Identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole.
Berberis lyceum and Fumaria indica: in vitro cytotoxicity, antioxidant activity, and in silico screening of their selected phytochemicals as novel hepatitis C virus nonstructural protein 5A inhibitors.
Beyond Members of the Flaviviridae Family, Sofosbuvir Also Inhibits Chikungunya Virus Replication.
Beyond sofosbuvir: what opportunity exists for a better nucleoside/nucleotide to treat hepatitis C?
Binding mode determination of benzimidazole inhibitors of the hepatitis C virus RNA polymerase by a structure and dynamics strategy.
Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase.
Binding-site identification and genotypic profiling of hepatitis C virus polymerase inhibitors.
Biochemical analyses of the interactions between viral polymerases and RNAs.
Biochemical and kinetic analyses of NS5B RNA-dependent RNA polymerase of the hepatitis C virus.
Biochemical and Pre-Steady-State Kinetic Characterization of the Hepatitis C Virus RNA Polymerase (NS5BDelta21, HC-J4).
Biochemical and structural analysis of the NS5B RNA-dependent RNA polymerase of the hepatitis C virus.
Biochemical characterization of a hepatitis C virus RNA-dependent RNA polymerase mutant lacking the C-terminal hydrophobic sequence.
Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094.
Biochemical properties of full-length hepatitis C virus RNA-dependent RNA polymerase expressed in insect cells.
Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity.
Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir.
Bioengineered vaults: self-assembling protein shell-lipophilic core nanoparticles for drug delivery.
Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus.
Biotransformation of Daclatasvir in Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine ?-Oxidation and Rearrangement.
Blocking Zika virus vertical transmission.
Breaking self-tolerance toward cytochrome P4502E1 (CYP2E1) in chronic hepatitis C: possible role for molecular mimicry.
Broad-spectrum non-nucleoside inhibitors for caliciviruses.
Canonical 3'-deoxyribonucleotides as a chain terminator for HCV NS5B RNA-dependent RNA polymerase.
Cellular OCIAD2 protein is a proviral factor for hepatitis C virus replication.
Cellular RNA helicase p68 relocalization and interaction with the hepatitis C virus (HCV) NS5B protein and the potential role of p68 in HCV RNA replication.
Challenge to overcome: Nonstructural protein 5A-P32 deletion in direct-acting antiviral-based therapy for hepatitis C virus.
Changing the face of hepatitis C management - the design and development of sofosbuvir.
Chaperonin TRiC/CCT participates in replication of hepatitis C virus genome via interaction with the viral NS5B protein.
Characterization of a Threonine-Rich Cluster in Hepatitis C Virus Nonstructural Protein 5A and Its Contribution to Hyperphosphorylation.
Characterization of hepatitis C virus structural proteins with a recombinant baculovirus expression system.
Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition.
Characterization of monoclonal antibodies that specifically recognize the palm subdomain of hepatitis C virus nonstructural protein 5B polymerase.
Characterization of nonstructural protein membrane anchor deletion mutants expressed in the context of the hepatitis C virus polyprotein.
Characterization of Resistance to the Nonnucleoside NS5B Inhibitor Filibuvir in Hepatitis C Virus-Infected Patients.
Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients.
Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli.
Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides.
Characterization of the interaction between HCV NS5B and the human estrogen receptor alpha.
Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species.
Characterization of the metal ion binding properties of the hepatitis C virus RNA polymerase.
Characterization of the nuclear localization signal and subcellular distribution of hepatitis C virus nonstructural protein NS5A.
Characterization of the RNA-binding domains in the replicase proteins of tomato bushy stunt virus.
Characterization of thiobarbituric acid derivatives as inhibitors of hepatitis C virus NS5B polymerase.
Characterizing ?-helical peptide aggregation on supported lipid membranes using microcantilevers.
Cholesterol-Enriched Domain Formation Induced by Viral-Encoded, Membrane-Active Amphipathic Peptide.
Chronic hepatitis E in a heart transplant patient: sofosbuvir and ribavirin regimen not fully effective.
Classification of HCV NS5B Polymerase Inhibitors Using Support Vector Machine.
Cleavage of hepatitis C virus nonstructural protein 5A by a caspase-like protease(s) in mammalian cells.
Cleavage of the hepatitis C virus NS5A protein by caspase-3 in the interferon sensitivity-determining region in a sequence-dependent manner.
Clinical and in vitro resistance to GS-9669, a thumb site II nonnucleoside inhibitor of the hepatitis C virus NS5B polymerase.
Clinical evaluation of efficacy, tolerability and pharmacokinetics of yimitasvir phosphate in patients infected with hepatitis C virus.
Clinical evaluation of three anti-HCV ELISAs in patients with various liver diseases.
Clinical evidence and bioinformatics characterization of potential hepatitis C virus resistance pathways for sofosbuvir.
Clinical Pharmacokinetics of Ombitasvir.
Clinical Resistance to Velpatasvir (GS-5816), a Novel Pan-Genotypic Inhibitor of the Hepatitis C Virus NS5A Protein.
Cochaperone activity of human butyrate-induced transcript 1 facilitates hepatitis C virus replication through an Hsp90-dependent pathway.
Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice.
Combinations of cyclophilin inhibitor NIM811 with hepatitis C Virus NS3-4A Protease or NS5B polymerase inhibitors enhance antiviral activity and suppress the emergence of resistance.
Combining 3-D quantitative structure-activity relationship with ligand based and structure based alignment procedures for in silico screening of new hepatitis C virus NS5B polymerase inhibitors.
Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerases.
Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) of thiazolone derivatives as hepatitis C virus NS5B polymerase allosteric inhibitors.
Compensatory mutations restore the replication defects caused by cytotoxic T lymphocyte escape mutations in hepatitis C virus polymerase.
Computational Analysis of De Novo Evolution of Hepatitis C Virus NS5B Polymerase Inhibitors.
Computational drug repurposing study elucidating simultaneous inhibition of entry and replication of novel corona virus by Grazoprevir.
Computational study on the drug resistance mechanism of HCV NS5B RNA-dependent RNA polymerase mutants V494I, V494A, M426A, and M423T to Filibuvir.
Concomitant proton pump inhibitor use does not reduce the efficacy of elbasvir/grazoprevir: A pooled analysis of 1,322 patients with hepatitis C infection.
Conformation-Based Restrictions and Scaffold Replacements in the Design of Hepatitis C Virus Polymerase Inhibitors: Discovery of Deleobuvir (BI 207127).
Conserved determinants for membrane association of nonstructural protein 5A from hepatitis C virus and related viruses.
Construction and characterization of Genotype-3 hepatitis C virus replicon revealed critical genotype-3-specific polymorphism for drug resistance and viral fitness.
Control of template positioning during de novo initiation of RNA synthesis by the bovine viral diarrhea virus NS5B polymerase.
Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A.
Coordination of Hepatitis C Virus Assembly by Distinct Regulatory Regions in Nonstructural Protein 5A.
Correction to Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase.
Correction: Hepatitis C Virus Nonstructural Protein 5A Inhibits MG132-Induced Apoptosis of Hepatocytes in Line with NF-?B-Nuclear Translocation.
Cost-Effectiveness Analysis of Baseline Testing for Resistance-Associated Polymorphisms to Optimize Treatment Outcome in Genotype 1 Noncirrhotic Treatment-Naïve Patients With Chronic Hepatitis C Virus.
Cross-genotypic examination of hepatitis C virus polymerase inhibitors reveals a novel mechanism of action for thumb binders.
Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5.
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site.
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus.
Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase.
Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
Crystallographic identification of a noncompetitive inhibitor binding site on the hepatitis C virus NS5B RNA polymerase enzyme.
Current and evolving therapies for hepatitis C.
Cyclophilin A allows the allosteric regulation of a structural motif in the disordered domain 2 of NS5A and thereby fine-tunes HCV RNA replication.
Cyclophilin B escorts the hepatitis C virus RNA polymerase: a viral achilles heel?
Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase.
Cyclophilin B stimulates RNA synthesis by the HCV RNA dependent RNA polymerase.
Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B.
Daclatasvir for the treatment of chronic hepatitis C virus infection.
Daclatasvir-like inhibitors of NS5A block early biogenesis of hepatitis C virus-induced membranous replication factories, independent of RNA replication.
De novo initiation of RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase.
De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus.
De novo initiation pocket mutations have multiple effects on hepatitis C virus RNA-dependent RNA polymerase activities.
De novo RNA synthesis catalyzed by HCV RNA-dependent RNA polymerase.
Decentralized, Community-Based Hepatitis C Point-of-Care Testing and Direct-Acting Antiviral Treatment for People Who Inject Drugs and the General Population in Myanmar: Protocol for a Feasibility Study.
Defining the Role of Gut Bacteria in the Metabolism of Deleobuvir: In Vitro and In Vivo Studies.
Design and Construction of Aroyl-Hydrazone Derivatives: Synthesis, Crystal Structure, Molecular Docking and Their Biological Activities.
Design and evaluation of novel tetracyclic benzofurans as palm site allosteric inhibitors of HCV NS5B polymerase.
Design and synthesis of 2,3,4,9-tetrahydro-1H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase.
Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase.
Design and synthesis of lactam-thiophene carboxylic acids as potent hepatitis C virus polymerase inhibitors.
Design and Synthesis of Novel Carbocyclic Versions of 2'-spirocyclopropyl Ribonucleosides as Potent Anti-HCV Agents.
Design, expression, and purification of a Flaviviridae polymerase using a high-throughput approach to facilitate crystal structure determination.
Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor.
Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.
Design, synthesis, and structure-activity relationships of novel imidazo[4,5-c]pyridine derivatives as potent non-nucleoside inhibitors of hepatitis C virus NS5B.
Design, synthesis, assessment, and molecular docking of novel pyrrolopyrimidine (7-deazapurine) derivatives as non-nucleoside hepatitis C virus NS5B polymerase inhibitors.
Destabilization of PDK1 by Hsp90 inactivation suppresses hepatitis C virus replication through inhibition of PRK2-mediated viral RNA polymerase phosphorylation.
Detailed computational study of the active site of the hepatitis C viral RNA polymerase to aid novel drug design.
Detection of antigens related to hepatitis C virus RNA encoding the NS5 region in the livers of patients with chronic type C hepatitis.
Detection of hepatitis C virus NS5 protein and genome in Chinese carcinoma of the extrahepatic bile duct and its significance.
Detection of Hepatitis C Virus Quasispecies Heterogeneity by Single-Strand Conformational Polymorphism.
Detection of hepatitis C virus with RNA polymerase chain reaction in fulminant hepatic failure.
Detergent-induced activation of the hepatitis C virus genotype 1b RNA polymerase.
Determinants for membrane association of the hepatitis C virus RNA-dependent RNA polymerase.
Determination and control of TEMPO, a potentially genotoxic free radical reagent used in the synthesis of filibuvir.
Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase.
Development of carboxylic acid replacements in indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase.
Development of intergenotypic chimeric replicons to determine the broad-spectrum antiviral activities of hepatitis C virus polymerase inhibitors.
Development of recombinant hepatitis C virus with NS5A from strains of genotypes 1 and 2.
Development of the system ensuring a high-level expression of hepatitis C virus nonstructural NS5B and NS5A proteins.
Different mechanisms of hepatitis C virus RNA polymerase activation by cyclophilin A and B in vitro.
Different Molecular Mechanisms of Inhibition of Bovine Viral Diarrhea Virus and Hepatitis C Virus RNA-Dependent RNA Polymerases by a Novel Benzimidazole.
Differential effect of interferon on hepatitis C virus 1b quasispecies in the nonstructural protein 5A gene.
Differential Proteomics Reveals Discrete Functions of Proteins Interacting with Hypo- versus Hyper-phosphorylated NS5A of the Hepatitis C Virus.
Difluoromethylornithine (DFMO), an Inhibitor of Polyamine Biosynthesis, and Antioxidant N-Acetylcysteine Potentiate Immune Response in Mice to the Recombinant Hepatitis C Virus NS5B Protein.
Dinucleotide analogues as novel inhibitors of RNA-dependent RNA polymerase of hepatitis C Virus.
Direct binding of a hepatitis C virus inhibitor to the viral capsid protein.
Direct detection of circulating hepatitis C virus RNA using probes from the 5' untranslated region.
Direct interaction between nucleolin and hepatitis C virus NS5B.
Discovery and Early Development of TMC647055, a Non-Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase.
Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase.
Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase.
Discovery of (7R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus NS5B Polymerase.
Discovery of (R)-6-Cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a Potent and Orally Available Hepatitis C Virus Polymerase Inhibitor.
Discovery of 4H-pyrazolo[1,5-a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase.
Discovery of a Silicon-Containing Pan-Genotype Hepatitis C Virus NS5A Inhibitor.
Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase.
Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor.
Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase.
Discovery of conformationally constrained tetracyclic compounds as potent hepatitis C virus NS5B RNA polymerase inhibitors.
Discovery of hit molecules targeting allosteric site of hepatitis C virus NS5B polymerase.
Discovery of Metal Ions Chelator Quercetin Derivatives with Potent Anti-HCV Activities.
Discovery of N-[4-[6-tert-Butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B Polymerase.
Discovery of Naturally Occurring Aurones That Are Potent Allosteric Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase.
Discovery of new scaffolds for rational design of HCV NS5B polymerase inhibitors.
Discovery of novel Hepatitis C virus inhibitor targeting multiple allosteric sites of NS5B polymerase.
Discovery of Novel Hepatitis C Virus NS5B Polymerase Inhibitors by Combining Random Forest, Multiple e-Pharmacophore Modeling and Docking.
Discovery of novel natural flavonoids as potent antiviral candidates against hepatitis C virus NS5B polymerase.
Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles.
Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase.
Discovery of pentacyclic compounds as potent inhibitors of hepatitis C virus NS5B RNA polymerase.
Discovery of Potent Non-nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from Fragment Screening and Structure-Guided Design.
Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.
Discovery of SCH 900188: A Potent Hepatitis C Virus NS5B Polymerase Inhibitor Prodrug As a Development Candidate.
Discovery of substituted N-phenylbenzenesulphonamides as a novel class of non-nucleoside hepatitis C virus polymerase inhibitors.
Discovery of the First Thumb Pocket 1 NS5B Polymerase Inhibitor (BILB 1941) with Demonstrated Antiviral Activity in Patients Chronically Infected with Genotype 1 Hepatitis C Virus (HCV).
Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052.
Distribution of naturally -occurring NS5B resistance-associated substitutions in Egyptian patients with chronic Hepatitis C.
Docking ligands into flexible and solvated macromolecules. 2. Development and application of fitted 1.5 to the virtual screening of potential HCV polymerase inhibitors.
Domain 2 of nonstructural protein 5A (NS5A) of hepatitis C virus is natively unfolded.
Domain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A.
Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase.
Dual Allosteric Inhibitors Jointly Modulate Protein Structure and Dynamics in the Hepatitis C Virus Polymerase.
Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders.
Dynamics of HCV RNA-dependent RNA Polymerase NS5B in Complex with RNA.
Effect of Hepatitis C Virus (HCV) NS5B-Nucleolin Interaction on HCV Replication with HCV Subgenomic Replicon.
Effect of metal ion binding on the structural stability of the hepatitis C virus RNA polymerase.
Effect of mutation in the hepatitis C virus nonstructural 5B region on HCV replication.
Effect on Hepatitis C Virus Replication of Combinations of Direct-Acting Antivirals, Including NS5A Inhibitor Daclatasvir.
Effective epitope identification employing phylogenetic, mutational variability, sequence entropy, and correlated mutation analysis targeting NS5B protein of hepatitis C virus: from bioinformatics to therapeutics.
Effects of mutation in hepatitis C virus nonstructural protein 5A on interferon resistance mediated by inhibition of PKR kinase activity in mammalian cells.
Effects of mutations of the initiation nucleotides on hepatitis C virus RNA replication in the cell.
Efficacy and safety of a two-drug direct-acting antiviral agent regimen ruzasvir 180 mg and uprifosbuvir 450 mg for 12 weeks in adults with chronic hepatitis C virus genotype 1, 2, 3, 4, 5 or 6.
Efficacy and Safety of All-oral Emitasvir and Sofosbuvir in Patients with Genotype 1b HCV Infections without Cirrhosis.
Efficacy and safety of sofosbuvir-based therapy for the treatment of chronic hepatitis C in treatment-naïve and treatment-experienced patients.
Efficacy and safety of sofosbuvir-containing regimens in chronic hepatitis C patients with genotype 2 and 3: a comprehensive analysis of 18 randomized controlled trials.
Efficiency of incorporation and chain termination determines the inhibition potency of 2'-modified nucleotide analogs against hepatitis C virus polymerase.
Efficient In Silico Assay of Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase by Structure-Based Virtual Screening and In Vitro Evaluation.
Efficient rescue of hepatitis C virus RNA replication by trans-complementation with nonstructural protein 5A.
Elongation of synthetic RNA templates by hepatitis C virus NS5B polymerase.
Emergence of hepatitis C virus NS5A L31V plus Y93H variant upon treatment failure of daclatasvir and asunaprevir is relatively resistant to ledipasvir and NS5B polymerase nucleotide inhibitor GS-558093 in human hepatocyte chimeric mice.
Engineered retargeting of viral RNA replication complexes to an alternative intracellular membrane.
Enzymatic activities of the GB virus-B RNA-dependent RNA polymerase.
Enzymatic characterization of the full-length and C-terminally truncated hepatitis C virus RNA polymerases: function of the last 21 amino acids of the C terminus in template binding and RNA synthesis.
Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly.
Establishment of stable HeLa cell lines expressing enzymatically active hepatitis C virus RNA polymerase.
Ethanol inhibition: the humoral and cellular immune response to hepatitis C virus NS5 protein after genetic immunization.
Etodolac Thiosemicarbazides: A novel class of hepatitis C virus NS5B polymerase inhibitors.
Evaluation of a prototype HCV NS5b assay for typing strains of hepatitis C virus isolated from Tunisian haemodialysis patients.
Evaluation of antiviral effects of novel NS5A inhibitors in hepatitis C virus cell culture system with full-genome infectious clones.
Evaluation of Coumarin and Neoflavone Derivatives as HCV NS5B Polymerase Inhibitors.
Evaluation of Inhibitory effects of Thiobarbituric Acid Derivatives Targeting HCV NS5B Polymerase.
Evaluation of methods for hepatitis C virus detection in archival liver biopsies. Comparison of histology, immunohistochemistry, in-situ hybridization, reverse transcriptase polymerase chain reaction (RT-PCR) and in-situ RT-PCR.
Evaluation of sofosbuvir activity and resistance profile against West Nile virus in vitro.
Evaluation of the effect of mericitabine at projected therapeutic and supratherapeutic doses on cardiac repolarization in healthy subjects: A thorough QT/QTc study.
Evidence for action of ribavirin through the hepatitis C virus RNA polymerase.
Evidence for Internal Initiation of RNA Synthesis by the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B In Cellulo.
Evolution of the NS3 and NS5B regions of the hepatitis C virus during disease recurrence after liver transplantation.
Expensiveness of hepatitis C virus polymerase inhibitor sofosbuvir: a warrant for therapeutic drug monitoring of compliance.
Expression and purification of untagged full-length HCV NS5B RNA-dependent RNA polymerase.
Expression of a hepatitis C virus NS3 protease-NS4A fusion protein in Escherichia coli.
Expression of hepatitis C virus NS5B protein: characterization of its RNA polymerase activity and RNA binding.
Finding new medicines for flaviviral targets.
First-in-Human Study of the Pharmacokinetics and Antiviral Activity of IDX375, a Novel Nonnucleoside Hepatitis C Virus Polymerase Inhibitor.
Fluorescence resonance energy transfer-based intracellular assay for the conformation of hepatitis C virus drug target NS5A.
Follow-up study of anti-hepatitis C virus antibodies in blood donors implicated in post-transfusion non-A, non-B hepatitis.
Forthcoming challenges in the management of STAT-C therapy.
Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors.
Functional analysis of RNA binding by the hepatitis C virus RNA-dependent RNA polymerase.
Functional characterization of fingers subdomain-specific monoclonal antibodies inhibiting the hepatitis C virus RNA-dependent RNA polymerase.
Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase.
Further insights into the roles of GTP and the C terminus of the hepatitis C virus polymerase in the initiation of RNA synthesis.
Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase.
Further studies on hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors toward improved replicon cell activities: benzimidazole and structurally related compounds bearing the 2-morpholinophenyl moiety.
General catalytic deficiency of hepatitis C virus RNA polymerase with an S282T mutation and mutually exclusive resistance towards 2'-modified nucleotide analogues.
Genetic and biochemical diversity in the HCV NS5B RNA polymerase in the context of interferon alpha plus ribavirin therapy.
Genetic complementation of hepatitis C virus nonstructural protein functions associated with replication exhibits requirements that differ from those for virion assembly.
Genetic diversity of the hepatitis C virus: impact and issues in the antiviral therapy.
Genomic-Scale Interaction Involving Complementary Sequences in the Hepatitis C Virus 5'UTR Domain IIa and the RNA-Dependent RNA Polymerase Coding Region Promotes Efficient Virus Replication.
Genotypic and phenotypic analyses of hepatitis C virus variants observed in clinical studies of VX-222, a nonnucleoside NS5B polymerase inhibitor.
Glecaprevir/Pibrentasvir in patients with hepatitis C virus genotype 1 or 4 and past direct-acting antiviral treatment failure.
GPS2 is required for the association of NS5A with VAP-A and hepatitis C virus replication.
GS-9857 in patients with chronic hepatitis C virus genotype 1-4 infection: a randomized, double-blind, dose-ranging phase 1 study.
HA1077 displays synergistic activity with daclatasvir against hepatitis C virus and suppresses the emergence of NS5A resistance-associated substitutions in mice.
HCV Genotype 6a Escape from and Resistance to Velpatasvir, Pibrentasvir, and Sofosbuvir in Robust Infectious Cell Culture Models.
HCV NS5A Inhibitors Modulate Multiple Aspects of NS5A Expression.
HCV796: A selective nonstructural protein 5B polymerase inhibitor with potent anti-hepatitis C virus activity in vitro, in mice with chimeric human livers, and in humans infected with hepatitis C virus.
Hemin potentiates the anti-hepatitis C virus activity of the antimalarial drug artemisinin.
Hepatitis C NS5B polymerase inhibitors: 4,4-Dialkyl-1-hydroxy-3-oxo-3,4-dihydronaphthalene-3-yl benzothiadiazine derivatives.
Hepatitis C NS5B polymerase inhibitors: Functional equivalents for the benzothiadiazine moiety.
Hepatitis C RNA-dependent RNA polymerase inhibitors: a review of structure-activity and resistance relationships; different scaffolds and mutations.
Hepatitis C therapy with HCV NS5B polymerase inhibitors.
Hepatitis C virus (HCV) NS2 protein up-regulates HCV IRES-dependent translation and down-regulates NS5B RdRp activity.
Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity.
Hepatitis C virus co-opts Ras-GTPase-activating protein-binding protein 1 for its genome replication.
Hepatitis C virus core protein binds to a C-terminal region of NS5B RNA polymerase.
Hepatitis C Virus Genetic Variability and the Presence of NS5B Resistance-Associated Mutations as Natural Polymorphisms in Selected Genotypes Could Affect the Response to NS5B Inhibitors.
Hepatitis C virus genotypes and quasispecies.
Hepatitis C Virus in mainland China with an emphasis on genotype and subtype distribution.
Hepatitis C Virus Nonstructural 5A Protein (HCV-NS5A) Inhibits Hepatocyte Apoptosis through the NF-?b/miR-503/bcl-2 Pathway.
Hepatitis C virus nonstructural 5B protein regulates tumor necrosis factor alpha signaling through effects on cellular IkappaB kinase.
Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding protein.
Hepatitis C virus nonstructural protein 5A contains potential transcriptional activator domains.
Hepatitis C virus nonstructural protein 5A favors upregulation of gluconeogenic and lipogenic gene expression leading towards insulin resistance: a metabolic syndrome.
Hepatitis C virus nonstructural protein 5A inhibitors: novel target-now for new trials and new treatment strategies.
Hepatitis C Virus Nonstructural Protein 5A Inhibits MG132-Induced Apoptosis of Hepatocytes in Line with NF-?B-Nuclear Translocation.
Hepatitis C virus nonstructural protein 5A inhibits thapsigargin-induced apoptosis.
Hepatitis C virus nonstructural protein 5A inhibits tumor necrosis factor-alpha-mediated apoptosis in Huh7 cells.
Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines.
Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling.
Hepatitis C virus nonstructural protein NS(3) and telomerase activity.
Hepatitis C virus nonstructural protein NS4B transforms NIH3T3 cells in cooperation with the Ha-ras oncogene.
Hepatitis C virus nonstructural protein specific T cells are associated with virological responses to combination therapy in chronic HCV patients.
Hepatitis C virus NS2/3 protease regulates HCV IRES-dependent translation and NS5B RdRp activity.
Hepatitis C virus NS5A and subgenomic replicon activate NF-kappaB via tyrosine phosphorylation of IkappaBalpha and its degradation by calpain protease.
Hepatitis C virus NS5A colocalizes with the core protein on lipid droplets and interacts with apolipoproteins.
Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis.
Hepatitis C virus NS5A protein modulates template selection by the RNA polymerase in in vitro system.
Hepatitis C virus NS5B and host cyclophilin A share a common binding site on NS5A.
Hepatitis C virus NS5B polymerase exhibits distinct nucleotide requirements for initiation and elongation.
Hepatitis C virus NS5B polymerase primes innate immune signaling.
Hepatitis C virus NS5B polymerase: QM/MM calculations show the important role of the internal energy in ligand binding.
Hepatitis C Virus NS5B Protein Delays S Phase Progression in Human Hepatocyte-derived Cells by Relocalizing Cyclin-dependent Kinase 2-interacting Protein (CINP).
Hepatitis C virus NS5B protein is a membrane-associated phosphoprotein with a predominantly perinuclear localization.
Hepatitis C virus NS5B RNA replicase specifically binds ribosomes.
Hepatitis C Virus Particle Assembly Involves Phosphorylation of NS5A by the c-Abl Tyrosine Kinase.
Hepatitis C virus quasispecies variability modulates nonstructural protein 5A transcriptional activation, pointing to cellular compartmentalization of virus-host interactions.
Hepatitis C virus replication is modulated by the interaction of non-structural protein NS5B and fatty acid synthase.
Hepatitis C Virus RNA Elimination and Development of Resistance in Replicon Cells Treated with BMS-790052.
Hepatitis C virus RNA polymerase and NS5A complex with a SNARE-like protein.
Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90.
Hepatitis C virus RNA replication requires a conserved structural motif within the transmembrane domain of the NS5B RNA-dependent RNA polymerase.
Hepatitis C virus RNA synthesis in a cell-free system isolated from replicon-containing hepatoma cells.
Hepatitis C virus RNA-dependent RNA polymerase (NS5B polymerase).
Hepatitis C Virus RNA-Dependent RNA Polymerase (NS5B Polymerase).
Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin.
Hepatitis C Virus RNA-Dependent RNA Polymerase Is Regulated by Cysteine S-Glutathionylation.
Hepatitis C virus RNA-dependent RNA polymerase: study on the inhibition mechanism by pyrogallol derivatives.
Hepatitis C Virus Subverts Human Choline Kinase-? To Bridge Phosphatidylinositol-4-Kinase III? (PI4KIII?) and NS5A and Upregulates PI4KIII? Activation, Thereby Promoting the Translocation of the Ternary Complex to the Endoplasmic Reticulum for Viral Replication.
Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability.
Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing.
Hepatitis G virus infection in patients with hepatocellular carcinoma in Recife, Brazil.
Hepatitis C virus nonstructural 5A protein inhibits the starvation?induced apoptosis of hepatoblastoma cells by increasing Beclin 1 expression.
Heterogeneity within the nonstructural protein 5-encoding region of hepatitis C viruses from a single patient.
Heterologous RNA replication enhancer stimulates in vitro RNA synthesis and template-switching by the carmovirus, but not by the tombusvirus, RNA-dependent RNA polymerase: implication for modular evolution of RNA viruses.
High resolution footprinting of the hepatitis C virus polymerase NS5B in complex with RNA.
High-affinity aptamers to subtype 3a hepatitis C virus polymerase display genotypic specificity.
Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication.
Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro.
Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B.
Human Immunodeficiency Virus Viral Load Rebound Near Delivery in Previously Suppressed, Combination Antiretroviral Therapy-Treated Pregnant Women.
Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives.
Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B.
Hydrogen/Deuterium Exchange Kinetics Demonstrate Long Range Allosteric Effects of Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase.
Hydrophobic and Charged Residues in the C-Terminal Arm of Hepatitis C Virus RNA-Dependent RNA Polymerase Regulate Initiation and Elongation.
Hyperphosphorylation of the hepatitis C virus NS5A protein requires an active NS3 protease, NS4A, NS4B, and NS5A encoded on the same polyprotein.
Identification and Analysis of Novel Inhibitors against NS3 Helicase and NS5B RNA-Dependent RNA Polymerase from Hepatitis C Virus 1b (Con1).
Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors (double dagger).
Identification and functional characterization of the nascent RNA contacting residues of the hepatitis C virus RNA-dependent RNA polymerase.
Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus.
Identification of a C-terminal regulatory motif in hepatitis C virus RNA-dependent RNA polymerase: structural and biochemical analysis.
Identification of a novel resistance mutation for benzimidazole inhibitors of the HCV RNA-dependent RNA polymerase.
Identification of a ribavirin-resistant NS5B mutation of hepatitis C virus during ribavirin monotherapy.
Identification of a structural element of the hepatitis C virus minus strand RNA involved in the initiation of RNA synthesis.
Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step.
Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase.
Identification of Anthranilic Acid Derivatives as a Novel Class of Allosteric Inhibitors of Hepatitis C NS5B Polymerase.
Identification of B cell epitopes of hepatitis C virus RNA dependent RNA polymerase.
Identification of constrained peptides that bind to and preferentially inhibit the activity of the hepatitis C viral RNA-dependent RNA polymerase.
Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase.
Identification of novel HCV RNA-dependent RNA polymerase inhibitors using pharmacophore-guided virtual screening.
Identification of potential anti-hepatitis C virus agents targeting non structural protein 5B using computational techniques.
Identification of potential inhibitors for HCV NS5b of genotype 4a by combining dynamic simulation, protein-ligand interaction fingerprint, 3D pharmacophore, docking and 3D QSAR.
Identification of RNA ligands that bind hepatitis C virus polymerase selectively and inhibit its RNA synthesis from the natural viral RNA templates.
Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture.
Identification of the sequence on NS4A required for enhanced cleavage of the NS5A/5B site by hepatitis C virus NS3 protease.
Identification of thieno[3,2-b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase.
Identification of two flavivirus-like genomes in the GB hepatitis agent.
IDX-184 is a superior HCV direct-acting antiviral drug: a QSAR study.
Imidazopyridazine hepatitis C virus polymerase inhibitors. Structure-activity relationship studies and the discovery of a novel, traceless prodrug mechanism.
Immune response to a hepatitis C virus nonstructural protein in chronic hepatitis C virus infection.
Impact of antiretroviral therapy on the variability of the HCV NS5B polymerase in HIV/HCV co-infected patients.
Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: From benzimidazole to indole scaffolds.
Improved serodiagnosis of non-A, non-B hepatitis by an assay detecting antibody to hepatitis C virus core antigen.
Improvement of hepatitis C virus RNA polymerase chain reaction through a multicentre quality control study. French Study Group for the Standardization of Hepatitis C Virus PCR.
Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor.
In Silico Approaches to the Design of NS5A Inhibitors.
In silico prediction of SARS-CoV-2 main protease and polymerase inhibitors: 3D-Pharmacophore modelling.
In situ enzymatic oligonucleotide amplification of hepatitis C virus-RNA in liver biopsy specimens (reverse transcriptase in situ polymerase chain reaction) after orthotopic liver transplantation for hepatitis C-related liver disease.
In vitro activity and resistance profile of dasabuvir, a nonnucleoside hepatitis C virus polymerase inhibitor.
In Vitro Activity of BMS-790052 on Hepatitis C Virus Genotype 4 NS5A.
In vitro resistance study of AG-021541, a novel nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
In vitro selection of RNA aptamers that bind the RNA-dependent RNA polymerase of hepatitis C virus: a possible role of GC-rich RNA motifs in NS5B binding.
In vitro selection of the 3'-untranslated regions of the human liver mRNA that bind to the HCV nonstructural protein 5B.
Inducible CYP4F12 enhances Hepatitis C virus infection via association with viral nonstructural protein 5B.
Infrequent development of resistance in genotype 1-6 hepatitis C virus-infected subjects treated with sofosbuvir in phase 2 and 3 clinical trials.
Inhibition of dengue virus polymerase by blocking of the RNA tunnel.
Inhibition of expression of rna polymerase with small interfering RNAs targeting a conserved motif in the respective viral genes in viruses of the family Flaviviridae.
Inhibition of hepatitis C viral RNA-dependent RNA polymerase by ?-P-boranophosphate nucleotides: Exploring a potential strategy for mechanism-based HCV drug design.
Inhibition of hepatitis C virus (HCV) replication by specific RNA aptamers against HCV NS5B RNA replicase.
Inhibition of hepatitis C virus (HCV) RNA polymerase by DNA aptamers: mechanism of inhibition of in vitro RNA synthesis and effect on HCV-infected cells.
Inhibition of hepatitis C virus nonstructural protein, helicase activity, and viral replication by a recombinant human antibody clone.
Inhibition of hepatitis C virus NS5B polymerase by S-trityl-l-cysteine derivatives.
Inhibition of Hepatitis C Virus Replication by GS-6620, a Potent C-Nucleoside Monophosphate Prodrug.
Inhibition of hepatitis C virus replication by Monascus pigment derivatives that interfere with viral RNA polymerase activity and the mevalonate biosynthesis pathway.
Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs.
Inhibition of intrahepatic gamma interferon production by hepatitis C virus nonstructural protein 5A in transgenic mice.
Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention.
Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2'-deoxy-2'-fluorocytidine.
Inhibitors for the hepatitis C virus RNA polymerase explored by SAR with advanced machine learning methods.
Inhibitors of hepatitis C virus polymerase: synthesis and biological characterization of unsymmetrical dialkyl-hydroxynaphthalenoyl-benzothiadiazines.
Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides.
Inhibitors of the HCV NS5B polymerase: new hope for the treatment of hepatitis C infections.
Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and Resistance.
Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B.
Initial binding of the broad spectrum antiviral nucleoside ribavirin to the hepatitis C virus RNA polymerase.
Initial results of efficacy and safety of Sofosbuvir among Pakistani Population: A real life trial - Hepatitis Eradication Accuracy Trial of Sofosbuvir (HEATS).
Initiation of RNA synthesis by the hepatitis C virus RNA-dependent RNA polymerase is affected by the structure of the RNA template.
Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes.
Insight into the drug resistance mechanisms of GS-9669 caused by mutations of HCV NS5B polymerase via molecular simulation.
Insight into the Structural Requirements of Benzothiadiazine Scaffold-Based Derivatives as Hepatitis C Virus NS5B Polymerase Inhibitors Using 3D-QSAR, Molecular Docking and Molecular Dynamics.
Insights into structural dynamics of allosteric binding sites in HCV RNA-dependent RNA polymerase.
Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles.
Interaction of hepatitis C virus NS5A with La protein revealed by T7 phage display.
Interaction of Nonstructural Protein 5A of the Hepatitis C Virus with Src Homology 3 Domains Using Noncanonical Binding Sites.
Interaction of stomatin with hepatitis C virus RNA polymerase stabilizes the viral RNA replicase complexes on detergent-resistant membranes.
Interaction of the hepatitis B virus X protein with the lysine methyltransferase SET and MYND domain-containing 3 induces activator protein 1 activation.
Interaction study between HCV NS5A-D2 and NS5B using
Interaction with a ubiquitin-like protein enhances the ubiquitination and degradation of hepatitis C virus RNA-dependent RNA polymerase.
Interactions between Viperin, Vesicle-Associated Membrane Protein A, and Hepatitis C Virus Protein NS5A Modulate Viperin Activity and NS5A Degradation.
Interactions of the Disordered Domain II of Hepatitis C Virus NS5A with Cyclophilin A, NS5B, and Viral RNA Show Extensive Overlap.
Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site.
Interference of hepatitis C virus replication in cell culture by antisense peptide nucleic acids targeting the X-RNA.
Interferon and ribavirin therapy does not select for resistance mutations in hepatitis C virus polymerase.
Internal initiation sites of de novo RNA synthesis within the hepatitis C virus polypyrimidine tract.
Intracellular Effects of the Hepatitis C Virus Nucleoside Polymerase Inhibitor RO5855 (Mericitabine Parent) and Ribavirin in Combination.
Intracellular hepatitis C virus RNA-dependent RNA polymerase activity.
Investigation of Interferon-? Response by a Single Amino Acid Substitution of Nonstructural Protein 5A in Hepatitis C Virus-Infected Patients.
Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.
Investigation of translocation, DNA unwinding, and protein displacement by NS3h, the helicase domain from the hepatitis C virus helicase.
Involvement of hepatitis C virus NS5A hyperphosphorylation mediated by casein kinase I-? in infectious virus production.
In vitro antiviral activities of extracts derived from Daucus maritimus seeds.
Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus.
Is investigation of hepatitis C virus NS5A gene heterogeneity a tool for predicting long-lasting response to interferon therapy in patients with HCV-1b chronic hepatitis?
JTK-853, a Novel Non-Nucleoside Hepatitis C Virus Polymerase Inhibitor, Demonstrates a High Genetic Barrier to Resistance in vitro.
Kinetic analysis of C-terminally truncated RNA-dependent RNA polymerase of hepatitis C virus.
Kinetic profile of a heterocyclic HCV replicon RNA synthesis inhibitor.
Lack of mother-to-infant transmission of hepatitis C virus in human immunodeficiency virus-seronegative women: a prospective study with hepatitis C virus RNA testing.
Large-scale structure-activity relationship study of hepatitis C virus NS5B polymerase inhibition using SMILES-based descriptors.
Ledipasvir/Sofosbuvir: a review of its use in chronic hepatitis C.
Ligand and structure based virtual screening strategies for hit-finding and optimization of hepatitis C virus (HCV) inhibitors.
Ligand-induced changes in hepatitis C virus NS5B polymerase structure.
Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein.
Liver histology in anti-HCV-positive persons with normal or minimally elevated aminotransferases.
Liver-targeted prodrugs of 2'-C-methyladenosine for therapy of hepatitis C virus infection.
Localization determines function: N-terminally truncated NS5A fragments accumulate in the nucleus and impair HCV replication.
Logical design of anti-prion agents using NAGARA.
Low susceptibility of asunaprevir towards R155K and D168A point mutations in HCV NS3/4A protease: A molecular dynamics simulation.
Mapping cooperative activity of the hepatitis C virus RNA-dependent RNA polymerase using genotype 1a-1b chimeras.
Mass balance, metabolite profile, and in vitro-in vivo comparison of clearance pathways of deleobuvir, a hepatitis C virus polymerase inhibitor.
MAVS-mediated apoptosis and its inhibition by viral proteins.
Mean protein evolutionary distance: a method for comparative protein evolution and its application.
Measurement of HCV RdRp activity with C-terminal 21 aa truncated NS5b protein: optimization of assay conditions.
Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
Mechanism of activation of beta-D-2'-deoxy-2'-fluoro-2'-c-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase.
Mechanism of an amphipathic alpha-helical peptide's antiviral activity involves size-dependent virus particle lysis.
Mechanism of de novo initiation by the hepatitis C virus RNA-dependent RNA polymerase: role of divalent metals.
Mechanism of hepatitis C virus RNA polymerase inhibition with dihydroxypyrimidines.
Mechanism of inhibition for BMS-791325, a novel non-nucleoside inhibitor of hepatitis C virus NS5B polymerase.
Mechanisms of activity and inhibition of the hepatitis C virus RNA-dependent RNA polymerase.
Mechanistic Characterization of GS-9190 (Tegobuvir), a Novel Nonnucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase.
Mechanistic insight on the remdesivir binding to RNA-Dependent RNA polymerase (RdRp) of SARS-cov-2.
Mechanistic study of HCV polymerase inhibitors at individual steps of the polymerization reaction.
Medicinal chemistry of anthranilic acid derivatives: A mini review.
Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication.
Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans.
Microbead-based affinity chromatography chip using RNA aptamer modified with photocleavable linker.
Miniaturization of a hepatitis C virus RNA polymerase assay using a -102 degrees C cooled CCD camera-based imaging system.
Modification of hepatitis C virus 1b RNA polymerase to make a highly active JFH1-type polymerase by mutation of the thumb domain.
Modular Combination of Proteolysis-Responsive Transcription and Spherical Nucleic Acids for Smartphone-Based Colorimetric Detection of Protease Biomarkers.
Modulation of cell growth by the hepatitis C virus nonstructural protein NS5A.
Modulation of hepatitis C virus RNA-dependent RNA polymerase activity by structure-based site-directed mutagenesis.
Modulation of the hepatitis C virus RNA-dependent RNA polymerase activity by the non-structural (NS) 3 helicase and the NS4B membrane protein.
Modulation of vaccine-induced immune responses to hepatitis C virus in rhesus macaques by altering priming before adenovirus boosting.
Molecular and structural basis for the roles of hepatitis C virus polymerase NS5B amino acids 15, 223, and 321 in viral replication and drug resistance.
Molecular design, synthesis and cell based HCV replicon assay of novel benzoxazole derivatives.
Molecular docking revealed the binding of nucleotide/side inhibitors to Zika viral polymerase solved structures.
Molecular mechanism of a thumb domain hepatitis C virus nonnucleoside RNA-dependent RNA polymerase inhibitor.
Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796.
Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design.
Molecular modeling and residue interaction network studies on the mechanism of binding and resistance of the HCV NS5B polymerase mutants to VX-222 and ANA598.
Molecular Neuroprotection Induced by Zinc-Dependent Expression of Hepatitis C-Derived Protein NS5A Targeting Kv2.1 Potassium Channels.
Molecular simulations illuminate the role of regulatory components of the RNA polymerase from the hepatitis C virus in influencing protein structure and dynamics.
Monitoring hepatitis C virus (HCV) RNA-dependent RNA polymerase oligomerization by a FRET-based in vitro system.
Monoclonal antibody recognizing N-terminal epitope of hepatitis C virus nonstructural 5B inhibits viral RNA replication.
Multiple e-pharmacophore modeling, 3D-QSAR, and high-throughput virtual screening of hepatitis C virus NS5B polymerase inhibitors.
Multiple interactions within the hepatitis C virus RNA polymerase repress primer-dependent RNA synthesis.
Multiple ligand detection and affinity measurement by ultrafiltration and mass spectrometry analysis applied to fragment mixture screening.
Multiple virtual screening approaches for finding new hepatitis C virus RNA-dependent RNA polymerase inhibitors: structure-based screens and molecular dynamics for the pursue of new poly pharmacological inhibitors.
Mutagenesis analysis of the rGTP-specific binding site of hepatitis C virus RNA-dependent RNA polymerase.
Mutagenic and inhibitory effects of ribavirin on hepatitis C virus RNA polymerase.
Mutational analysis of hepatitis C virus nonstructural protein 5A: potential role of differential phosphorylation in RNA replication and identification of a genetically flexible domain.
Mutational Analysis of Hepatitis C Virus NS5B in the Subgenomic Replicon Cell Culture.
Mutational analysis of the structure and functions of hepatitis C virus RNA-dependent RNA polymerase.
Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro.
Mutations in nonstructural protein 5A gene and response to interferon in hepatitis C virus genotype 2 infection.
Mutations in NS5A region of hepatitis C virus genome correlate with presence of NS5A antibodies and response to interferon therapy for most common European hepatitis C virus genotypes.
Mutations in NS5B polymerase of hepatitis C virus: impacts on in vitro enzymatic activity and viral RNA replication in the subgenomic replicon cell culture.
Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A.
Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa.
Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection.
Mutations in the nonstructural protein 5A gene and response to interferon therapy in young patients with chronic hepatitis C virus 1b infection.
Mutations in the nonstructural region 5B of hepatitis C virus genotype 1b: their relation to viral load, response to interferon, and the nonstructural region 5A.
Mutations in the NS5A region do not predict interferon-responsiveness in american patients infected with genotype 1b hepatitis C virus.
N-Acetamideindolecarboxylic acid allosteric 'finger-loop' inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies.
Nanofiltration of single plasma donations: feasibility study.
Natural variation in drug susceptibility to HCV polymerase inhibitors in treatment-naïve HCV patient isolates.
Naturally occurring dominant drug resistance mutations occur infrequently in the setting of recently acquired hepatitis C.
Naturally occurring mutations in the nonstructural region 5B of hepatitis C virus (HCV) from treatment-naïve Korean patients chronically infected with HCV genotype 1b.
Naturally occurring substitutions conferring resistance to hepatitis C virus polymerase inhibitors in treatment-naive patients infected with genotypes 1-5.
New horizons in Hepatitis C antiviral therapy with direct-acting antivirals.
New Non-nucleoside Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase.
New NS5B polymerase inhibitors for hepatitis C.
New pseudodimeric aurones as palm pocket inhibitors of Hepatitis C virus RNA-dependent RNA polymerase.
New Pyrazolobenzothiazine Derivatives as Hepatitis C Virus NS5B Polymerase Palm Site I Inhibitors.
NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B.
NMR Structure and Molecular Dynamics of the In-Plane Membrane Anchor of Nonstructural Protein 5A from Bovine Viral Diarrhea Virus(,).
No detection of the NS5B S282T mutation in treatment-naïve genotype 1 HCV/HIV-1 coinfected patients using deep sequencing.
No influence of antiretroviral therapy on the mutation rate of the HCV NS5B polymerase in HIV/HCV-coinfected patients.
NOD1 Participates in the Innate Immune Response Triggered by Hepatitis C Virus Polymerase.
Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition.
Non-nucleoside benzimidazole-based allosteric inhibitors of the hepatitis C virus NS5B polymerase: inhibition of subgenomic hepatitis C virus RNA replicons in Huh-7 cells.
Non-nucleoside inhibitors binding to hepatitis C virus NS5B polymerase reveal a novel mechanism of inhibition.
Non-nucleoside inhibitors of hepatitis C virus polymerase: current progress and future challenges.
Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives.
Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency.
Non-nucleoside inhibitors of the hepatitis C virus NS5B RNA-dependant RNA polymerase: 2-aryl-3-heteroaryl-1,3-thiazolidin-4-one derivatives.
Nonstructural 5A Protein of Hepatitis C Virus Interferes with Toll-Like Receptor Signaling and Suppresses the Interferon Response in Mouse Liver.
Nonstructural 5A protein of hepatitis C virus modulates tumor necrosis factor alpha-stimulated nuclear factor kappa B activation.
Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virus.
Nonstructural protein 5A (NS5A) and human replication protein A increase the processivity of hepatitis C virus NS5B polymerase activity in vitro.
Nonstructural protein 5A does not contribute to the resistance of hepatitis C virus replication to interferon alpha in cell culture.
Nonstructural protein 5A is incorporated into hepatitis C virus low-density particle through interaction with core protein and microtubules during intracellular transport.
Nonstructural protein 5A of hepatitis C virus inhibits the function of karyopherin beta3.
Nonstructural protein 5B of hepatitis C virus.
Nonstructural protein 5B promotes degradation of the NORE1A tumor suppressor to facilitate hepatitis C virus replication.
Nonstructural protein precursor NS4A/B from hepatitis C virus alters function and ultrastructure of host secretory apparatus.
Nonstructural proteins 4A and 4B of hepatitis C virus transactivate the interleukin 8 promoter.
Novel 4-thiazolidinones as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase.
Novel fullerene derivatives as dual inhibitors of Hepatitis C virus NS5B polymerase and NS3/4A protease.
Novel guanosine derivatives against MERS CoV polymerase: An in silico perspective.
Novel inhibitors of hepatitis C virus RNA-dependent RNA polymerases.
Novel nonnucleoside inhibitor of hepatitis C virus RNA-dependent RNA polymerase.
NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling.
NS5ATP9 Contributes to Inhibition of Cell Proliferation by Hepatitis C Virus (HCV) Nonstructural Protein 5A (NS5A) via MEK/Extracellular Signal Regulated Kinase (ERK) Pathway.
NS5B RNA Dependent RNA Polymerase Inhibitors: The Promising Approach to Treat Hepatitis C Virus Infections.
NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase.
Nuclear immunostaining of hepatitis C infected hepatocytes with monoclonal antibodies to C100-3 nonstructural protein. Comparison of immunogold silver staining with other immunohistochemical methods.
Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: a Systematic Review.
Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase.
Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase, a Key Drug Target for COVID-19.
Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase.
Number and position of mutations in the interferon (IFN) sensitivity-determining region of the gene for nonstructural protein 5A correlate with IFN efficacy in hepatitis C virus genotype 1b infection.
OCIAD1 is a host mitochondrial substrate of the hepatitis C virus NS3-4A protease.
Oligomeric interaction of hepatitis C virus NS5B is critical for catalytic activity of RNA-dependent RNA polymerase.
Oligomerization and cooperative RNA synthesis activity of hepatitis C virus RNA-dependent RNA polymerase.
Ombitasvir/paritaprevir/ritonavir + dasabuvir +/- ribavirin in real world hepatitis C patients.
On the Origins of Hepatitis C Virus NS5B Polymerase Inhibitory Activity Using Machine Learning Approaches.
One-step RNA polymerase chain reaction for detection of hepatitis C virus RNA.
Only a small fraction of purified hepatitis C RNA-dependent RNA polymerase is catalytically competent: implications for viral replication and in vitro assays.
Open-label phase 2 study of faldaprevir, deleobuvir and ribavirin in Japanese treatment-naive patients with chronic hepatitis C virus genotype 1 infection.
Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate.
Optimization of thienopyrrole-based finger-loop inhibitors of the hepatitis C virus NS5B polymerase.
Optimizing choice of oral interferon-free treatment for genotype 1 hepatitis C virus using testing for NS5A resistance: a cost-utility analysis from the perspective of the Italian National Health Service.
Overall efficacy and safety results of sofosbuvir-based therapies in phase II and III studies.
Overall Structural Model of NS5A Protein from Hepatitis C Virus and Modulation by Mutations Confering Resistance of Virus Replication to Cyclosporin A.
PACSIN2 Interacts with Nonstructural Protein 5A and Regulates Hepatitis C Virus Assembly.
Parallel synthesis of 5-cyano-6-aryl-2-thiouracil derivatives as inhibitors for hepatitis C viral NS5B RNA-dependent RNA polymerase.
Parallel synthesis of pteridine derivatives as potent inhibitors for hepatitis C virus NS5B RNA-dependent RNA polymerase.
Partial reconstitution of hepatitis C virus RNA polymerization by heterologous expression of NS5B polymerase and template RNA in bacterial cell.
Persistent Innate Immune Stimulation Results in IRF3-Mediated but Caspase-Independent Cytostasis.
Pharmacoinformatics approach for investigation of alternative potential hepatitis C virus nonstructural protein 5B inhibitors.
Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of the Hepatitis C Virus NS5B Polymerase Inhibitor Sofosbuvir.
Pharmacokinetics of a Cholesterol-conjugated Aptamer Against the Hepatitis C Virus (HCV) NS5B Protein.
Pharmacokinetics of hepatitis C virus NS5A inhibitor JNJ-56914845 (GSK2336805) in subjects with hepatic impairment.
Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome.
Phosphocholine conjugation: an unexpected in vivo conjugation pathway associated with hepatitis c ns5b inhibitors featuring a bicyclo[1.1.1]pentane.
Phosphoramidate dinucleosides as hepatitis C virus polymerase inhibitors.
Phosphoramidate prodrugs of 2'-C-methylcytidine for therapy of hepatitis C virus infection.
Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication.
Phosphorylation at the N-terminal finger subdomain of a viral RNA-dependent RNA polymerase.
Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication.
Phosphorylation of hepatitis C virus NS5A nonstructural protein: a new paradigm for phosphorylation-dependent viral RNA replication?
Phosphorylation of hepatitis C virus RNA polymerases ser29 and ser42 by protein kinase C-related kinase 2 regulates viral RNA replication.
Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A.
Phosphorylation of nonstructural 5A protein of hepatitis C virus: HCV group-specific hyperphosphorylation.
Phosphorylation of Serine 225 in Hepatitis C Virus NS5A Regulates Protein-Protein Interactions.
Phylogenetic and 2D/3D Analysis of HCV 1a NS4A Gene/Protein in Pakistani Isolates.
Phylogenetic and structural analysis of HCV nonstructural protein 4A from Pakistani patients.
Physicochemical properties of the nucleoside prodrug R1626 leading to high oral bioavailability.
Plasmon-waveguide resonance spectroscopy applied to three potential drug targets: cyclooxygenase-2, hepatitis C virus RNA polymerase and integrin alpha V beta 3.
Polymerases of hepatitis C viruses and flaviviruses: Structural and mechanistic insights and drug development.
Polymorphisms of NS5B protein relates to early clearance of hepatitis C virus by interferon plus ribavirin: a pilot study.
Population Pharmacokinetic Analysis for Daclatasvir and Asunaprevir in Japanese Subjects With Chronic Hepatitis C Virus Infection.
Potency and resistance analysis of hepatitis C virus NS5B polymerase inhibitor BMS-791325 on all major genotypes.
Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase.
Preannealing of poly(A) template and oligo(dT) primer is not required for hepatitis C virus RNA-dependent RNA polymerase activity.
Preclinical and Clinical Resistance Profile of EDP-239, a Novel HCV NS5A Inhibitor.
Preclinical characterization of BMS-791325, an allosteric inhibitor of hepatitis C Virus NS5B polymerase.
Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase.
Preclinical Characterization of JTK-853, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase.
Preclinical Characterization of PF-00868554, a Potent Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-dependent RNA Polymerase.
Preclinical pharmacokinetics and metabolism of a potent non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase.
Preclinical Profile and Clinical Efficacy of a Novel HCV NS5A Inhibitor, EDP-239.
Prediction of Small Molecule Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus-2 RNA-dependent RNA Polymerase.
Prevalence and characteristics of naturally occurring sofosbuvir resistance-associated variants in patients with hepatitis C virus genotype 1b infection.
Prevalence of blood-borne viral infections among autopsy cases in Jordan.
Prevalence of Hepatitis C Virus Subgenotypes 1a and 1b in Japanese Patients: Ultra-Deep Sequencing Analysis of HCV NS5B Genotype-Specific Region.
Primer on Hepatitis C Virus Resistance to Direct-Acting Antiviral Treatment: A Practical Approach for the Treating Physician.
Probing the "fingers" domain binding pocket of Hepatitis C virus NS5B RdRp and D559G resistance mutation via Molecular Docking, Molecular Dynamics simulation and binding free energy calculations.
Probing the substrate specificity of hepatitis C virus NS3 serine protease by using synthetic peptides.
Production and characterization of active hepatitis C virus RNA-dependent RNA polymerase.
Production of infectious hepatitis C virus by using RNA polymerase I-mediated transcription.
Profile of alisporivir and its potential in the treatment of hepatitis C.
Progress towards improving antiviral therapy for hepatitis C with hepatitis C virus polymerase inhibitors. Part I: Nucleoside analogues.
Promoter/origin structure of the complementary strand of hepatitis C virus genome.
Properties of hepatitis C virus minigenome containing mutated 5'UTR region and luciferase transgene.
Protease inhibitor-resistant hepatitis C virus mutants with reduced fitness from impaired production of infectious virus.
Protein kinase C-related kinase 2 regulates hepatitis C virus RNA polymerase function by phosphorylation.
Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus.
PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
Purification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitors.
Pyridine Carboxamides: Potent Palm Site Inhibitors of HCV NS5B Polymerase.
Pyrophosphorolytic excision of nonobligate chain terminators by hepatitis C virus NS5B polymerase.
QSAR study of C allosteric binding site of HCV NS5B polymerase inhibitors by support vector machine.
QSAR study of HCV NS5B polymerase inhibitors using the genetic algorithm-multiple linear regression (GA-MLR).
Quantifying the Diversification of Hepatitis C Virus (HCV) during Primary Infection: Estimates of the In Vivo Mutation Rate.
Quantitative structure and bioactivity relationship study on HCV NS5B polymerase inhibitors.
R-1626, a specific oral NS5B polymerase inhibitor of hepatitis C virus.
R1626 plus peginterferon Alfa-2a provides potent suppression of hepatitis C virus RNA and significant antiviral synergy in combination with ribavirin.
RacGTPase-activating protein 1 interacts with hepatitis C virus polymerase NS5B to regulate viral replication.
Randomized, placebo-controlled, single-ascending-dose study of BMS-791325, a hepatitis C virus (HCV) NS5B polymerase inhibitor, in HCV genotype 1 infection.
Rapid and strong antiviral activity of the non-nucleosidic NS5B polymerase inhibitor BI 207127 in combination with peginterferon alfa 2a and ribavirin.
Rate-limiting pyrophosphate release by Hepatitis C Virus polymerase NS5B improves fidelity.
Real-world effectiveness and safety of sofosbuvir and nonstructural protein 5A inhibitors for chronic hepatitis C genotype 1, 2, 3, 4, or 6: a multicentre cohort study.
Recent advances in discovery and development of promising therapeutics against hepatitis C virus NS5B RNA-dependent RNA polymerase.
Recent advances in the analysis of HCV NS5B RNA-dependent RNA polymerase.
Recent advances in the chromatographic determination of the most commonly used anti-hepatitis C drug Sofosbuvir and its co-administered drugs in human plasma.
Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection.
Recent advances on the synthesis of hepatitis C virus NS5B RNA-dependent RNA-polymerase inhibitors.
Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
Recent progress in the development of selected hepatitis C virus NS3.4A protease and NS5B polymerase inhibitors.
Recombinant HCV NS3 and NS5B enzymes exhibit multiple posttranslational modifications for potential regulation.
Recombinant infectious bursal disease virus carrying hepatitis C virus epitopes.
Recombinant viral RdRps can initiate RNA synthesis from circular templates.
Reconstitution and Functional Analysis of a Full-Length Hepatitis C Virus NS5B Polymerase on a Supported Lipid Bilayer.
Recrutement des kinases PI4KIII aux organelles de réplication virale au cours de l'infection par le poliovirus et d'autres virus à ARN de polarité positive.
Regulation of De Novo Initiated RNA Synthesis in the Hepatitis C Virus RNA Dependent RNA Polymerase by Intermolecular Interactions.
Regulation of Hepatitis C Virus Replication by Nuclear Translocation of Nonstructural 5A Protein and Transcriptional Activation of Host Genes.
Regulation of hepatitis C virus replication by the core protein through its interaction with viral RNA polymerase.
Regulation of mRNA translation and cellular signaling by hepatitis C virus nonstructural protein NS5A.
Regulation of neuronal proapoptotic potassium currents by the hepatitis C virus nonstructural protein 5A.
Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation.
Regulation of the production of infectious genotype 1a hepatitis C virus by NS5A domain III.
Reliability of the third-generation recombinant immunoblot assay for hepatitis C virus.
Repositioning of RdRp Inhibitors against HCV NS5B Polymerase Utilizing Structure-Based Molecular Docking.
Resistance outside the substrate envelope: hepatitis C NS3/4A protease inhibitors.
Resistance profile of a hepatitis C virus RNA-dependent RNA polymerase benzothiadiazine inhibitor.
Resistance to excision determines efficiency of hepatitis C virus RNA-dependent RNA polymerase inhibition by nucleotide analogs.
Resistance to HCV nucleoside analogue inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
Resistance to nucleotide analogue inhibitors of hepatitis C virus NS5B: mechanisms and clinical relevance.
Resolution of the interaction mechanisms and characteristics of non-nucleoside inhibitors of hepatitis C virus polymerase.
Retraction. Oligomeric interaction of hepatitis C virus NS5B is critical for catalytic activity of RNA-dependent RNA polymerase.
Reversal of nonstructural protein 3-specific CD4(+) T cell dysfunction in patients with persistent hepatitis C virus infection.
Review article: novel therapeutic options for chronic hepatitis C.
Ribavirin mode of action in chronic hepatitis C: from clinical use back to molecular mechanisms.
Ribavirin resistance in hepatitis C virus replicon-containing cell lines conferred by changes in the cell line or mutations in the replicon RNA.
Ribonucleotide reductase M2 promotes RNA replication of hepatitis C virus by protecting NS5B protein from hPLIC1-dependent proteasomal degradation.
RNA polymerase as an antiviral target of hepatitis C virus.
RNA template-mediated inhibition of hepatitis C virus RNA-dependent RNA polymerase activity.
RNA unwinding activity of the hepatitis C virus NS3 helicase is modulated by the NS5B polymerase.
RNA-binding protein hnRNP D modulates internal ribosome entry site-dependent translation of hepatitis C virus RNA.
RNA-dependent RNA polymerase activity of the soluble recombinant hepatitis C virus NS5B protein truncated at the C-terminal region.
RNA-dependent RNA polymerase encoded by hepatitis C virus: biomedical applications.
RNA-dependent RNA polymerase of hepatitis C virus binds to its coding region RNA stem-loop structure, 5BSL3.2, and its negative strand.
RNA-dependent RNA polymerase of hepatitis C virus.
RNA-dependent RNA polymerase of hepatitis C virus: study on inhibition by alpha,gamma-diketo acid derivatives.
RNA-dependent RNA polymerases from different hepatitis C virus genotypes reveal distinct biochemical properties and drug susceptibilities.
Robust antiviral activity of R1626, a novel nucleoside analog: a randomized, placebo-controlled study in patients with chronic hepatitis C.
Role for TBC1D20 and Rab1 in hepatitis C virus replication via interaction with lipid droplet-bound nonstructural protein 5A.
Safety analysis of sofosbuvir and ledipasvir for treating hepatitis C.
Safety, pharmacokinetics and antiviral activity of AT-527, a novel purine nucleotide prodrug, in HCV-infected subjects with and without cirrhosis.
Safety, pharmacokinetics and antiviral effect of BILB 1941, a novel hepatitis C virus RNA polymerase inhibitor, after 5 days oral treatment.
Safety, tolerability, and pharmacokinetics of AL-335 in healthy volunteers and hepatitis C virus-infected subjects.
SAR and mode of action of novel non-nucleoside inhibitors of Hepatitis C NS5b RNA polymerase.
SAR studies on a series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides: Potent inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.
Screening and molecular docking of selected phytochemicals against NS5B polymerase of hepatitis c virus.
Screening for hepatitis C virus non-nucleotide resistance mutations in treatment-naive women.
Screening of blood donations by hepatitis C virus polymerase chain reaction (HCV-PCR) improves safety of blood products by window period reduction.
Screening of hepatitis C NS5B polymerase inhibitors containing benzothiadiazine core: a steered molecular dynamics.
Secondary structure of the 3' terminus of hepatitis C virus minus-strand RNA.
Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479.
Selection and characterization of hepatitis C virus replicons dually resistant to the polymerase and protease inhibitors HCV-796 and boceprevir (SCH 503034).
Selection of 3'-template bases and initiating nucleotides by hepatitis C virus NS5B RNA-dependent RNA polymerase.
Selection of DNA aptamers that bind the RNA-dependent RNA polymerase of hepatitis C virus and inhibit viral RNA synthesis in vitro.
Selection of replicon variants resistant to ACH-806, a novel hepatitis C virus inhibitor with no cross-resistance to NS3 protease and NS5B polymerase inhibitors.
Selection of RNA aptamers that are specific and high-affinity ligands of the hepatitis C virus RNA-dependent RNA polymerase.
Selective stimulation of hepatitis C virus and pestivirus NS5B RNA polymerase activity by GTP.
Sequence variation in hepatitis C virus nonstructural protein 5A predicts clinical outcome of pegylated interferon/ribavirin combination therapy.
Sequential Phosphorylation of the Hepatitis C Virus NS5A Protein Depends on NS3-Mediated Autocleavage between NS3 and NS4A.
Sequential S232/S235/S238 Phosphorylation of the Hepatitis C Virus Nonstructural Protein 5A.
Ser(2194) is a highly conserved major phosphorylation site of the hepatitis C virus nonstructural protein NS5A.
Seraprevir and sofosbuvir for treatment of chronic hepatitis C virus infection: A single-arm, open-label, phase 3 trial.
Serine 229 balances the hepatitis C virus nonstructural protein NS5A between hypo- and hyper-phosphorylated states.
Serine 235 Is the Primary NS5A Hyperphosphorylation Site Responsible for Hepatitis C Virus Replication.
Severe acute respiratory syndrome coronavirus protein nsp1 is a novel eukaryotic translation inhibitor that represses multiple steps of translation initiation.
Severe acute respiratory syndrome coronavirus replication inhibitor that interferes with the nucleic Acid unwinding of the viral helicase.
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity.
Significance of specific antibody assay for genotyping of hepatitis C virus.
Silibinin and related compounds are direct inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
Similar compliance and effect of treatment in chronic hepatitis C resulting from intravenous drug use in comparison with other infection causes.
Simple but highly effective three-dimensional chemical-feature-based pharmacophore model for diketo acid derivatives as hepatitis C virus RNA-dependent RNA polymerase inhibitors.
Simultaneous detection of both hepatitis B virus DNA and hepatitis C virus RNA using a combined one-step polymerase chain reaction technique.
Single-chain antibodies against a plant viral RNA-dependent RNA polymerase confer virus resistance.
Sofosbuvir (GS-7977) plus peginterferon/ribavirin in treatment-naïve patients with HCV genotype 1: A randomized, 28-day, dose-ranging trial.
Sofosbuvir as a potential alternative to treat the SARS-CoV-2 epidemic.
Sofosbuvir for the treatment of chronic hepatitis C virus infection.
Sofosbuvir plus ribavirin with or without peginterferon for the treatment of hepatitis C virus: Results from a phase 3b study in China.
Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial.
Sofosbuvir, a novel nucleotide analogue inhibitor used for the treatment of hepatitis C virus.
Sofosbuvir, a NS5B polymerase inhibitor in the treatment of hepatitis C: a review of its clinical potential.
Sofosbuvir-Induced Erythrodermic Pityriasis Rubra Pilaris-Like Drug Eruption.
Sofosbuvir/Velpatasvir/Voxilaprevir: A Review in Chronic Hepatitis C.
Sofosbuvir/Velpatasvir: A Review in Chronic Hepatitis C.
Sofosbuvir: A novel treatment option for chronic hepatitis C infection.
Sofosbuvir: a review of its use in patients with chronic hepatitis C.
Sofosbuvir: first global approval.
Solid-phase synthesis and screening of macrocyclic nucleotide-hybrid compounds targeted to hepatitis C NS5B.
Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate.
Specific interaction between the hepatitis C virus NS5B RNA polymerase and the 3' end of the viral RNA.
Specific targeted antiviral therapy for hepatitis C.
Specificity and mechanism analysis of hepatitis C virus RNA-dependent RNA polymerase.
Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype-specific manner.
Stereoselective synthesis and biological evaluation as inhibitors of hepatitis C virus RNA polymerase of GSK3082 analogues with structural diversity at the 5-position.
Stimulation of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase activity by the NS3 protease domain and by HCV RNA-dependent RNA polymerase.
Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides.
Structural basis for resistance of the genotype 2b hepatitis C virus NS5B polymerase to site A non-nucleoside inhibitors.
Structural insights into NS5B protein of novel equine hepaciviruses and pegiviruses complexed with polymerase inhibitors.
Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A.
Structure and function of the Zika virus full-length NS5 protein.
Structure of hepatitis C virus polymerase in complex with primer-template RNA.
Structure-activity relationship (SAR) development and discovery of potent indole-based inhibitors of the hepatitis C virus (HCV) NS5B polymerase.
Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase.
Structure-Activity Relationships in the Development of Allosteric Hepatitis C Virus RNA-Dependent RNA Polymerase Inhibitors: Ten Years of Research.
Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase.
Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase.
Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication.
Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase.
Studies of benzothiadiazine derivatives as hepatitis C virus NS5B polymerase inhibitors using 3D-QSAR, molecular docking and molecular dynamics.
Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity.
Study Design Characteristics and Pharmacological Mechanisms in International Clinical Trials Registry Platform: Registered Clinical Trials on Antiviral Drugs for COVID-19.
Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase.
Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation.
Suppression of hepatitis C virus replication by protein kinase C-related kinase 2 inhibitors that block phosphorylation of viral RNA polymerase.
Suppression of Viral RNA Binding and the Assembly of Infectious Hepatitis C Virus Particles in vitro by Cyclophilin Inhibitors.
Surface plasmon resonance as a tool to select potent drug candidates for hepatitis C virus NS5B polymerase.
Syntheses of four peptides from the immunodominant region of hepatitis C viral pathogens using PS-TTEGDA support for the investigation of HCV infection in human blood.
Syntheses of immunodominant peptide regions of hepatitis C viral pathogens using PS-BDODMA resin: a single peptide derived from the conserved domain (E2/NS1) was highly effective in detecting anti-HCV antibodies.
Synthesis and Anti-HCV Activities of 4'-Fluoro-2'-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4'-Fluoro-2'- C-methyluridine 5'-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection.
Synthesis and anti-hepatitis C virus activity of 2'(beta)-hydroxyethyl and 4'(alpha)-hydroxymethyl carbodine analogues.
Synthesis and Antiviral Activity of a Series of 2'-C-Methyl-4'-thionucleoside Monophosphate Prodrugs.
Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase.
Synthesis and Antiviral Properties of Novel Tetracyclic Nucleoside Inhibitors of Hepatitis C NS5B Polymerase.
Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors.
Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability.
Synthesis and Biological Characterization of B-Ring Amino Analogues of Potent Benzothiadiazine Hepatitis C Virus Polymerase Inhibitors.
Synthesis and evaluation of novel phosphoramidate prodrugs of 2'-methyl cytidine as inhibitors of hepatitis c virus NS5B polymerase.
Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores.
Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.
Synthesis and properties of (alpha-P-borano)-nucleoside 5'-triphosphate analogues as potential antiviral agents.
Synthesis and SAR optimization of diketo acid pharmacophore for HCV NS5B polymerase inhibition.
Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: potent allosteric inhibitors of the hepatitis C virus NS5B polymerase.
Synthesis of 2,3-Dideoxy-2-fluoro-2,3-endo-methylene- and 2,3-Dideoxy-2-fluoro-3-C-hydroxymethyl-2,3-endo-methylene-pentofuranoses and Their Use in the Preparation of Conformationally Locked Bicyclic Nucleosides.
Synthesis of deleobuvir, a potent hepatitis C virus polymerase inhibitor, and its major metabolites labeled with carbon-13 and carbon-14.
Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase.
Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase.
Synthesis, in vitro and in silico NS5B polymerase inhibitory activity of benzimidazole derivatives.
Targeting the RdRp of Emerging RNA Viruses: The Structure-Based Drug Design Challenge.
Template requirement and initiation site selection by hepatitis C virus polymerase on a minimal viral RNA template.
Template requirements and binding of hepatitis C virus NS5B polymerase during in vitro RNA synthesis from the 3'-end of virus minus-strand RNA.
Template requirements for de novo RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase on the viral X RNA.
Template requirements for RNA synthesis by a recombinant hepatitis C virus RNA-dependent RNA polymerase.
Template/primer requirements and single nucleotide incorporation by hepatitis C virus nonstructural protein 5B polymerase.
Terminal nucleotidyl transferase activity of recombinant Flaviviridae RNA-dependent RNA polymerases: implication for viral RNA synthesis.
Tetrahydrobenzothiophene inhibitors of hepatitis C virus NS5B polymerase.
The "interferon sensitivity determining region" of hepatitis C virus is a stable sequence element.
The A150V Polymorphism of Genotype 3 Hepatitis C Virus Polymerase Inhibits Interferon Alfa by Suppressing Protein Kinase R Activation.
The amino terminal deletion mutants of hepatitis C virus nonstructural protein NS5A function as transcriptional activators in yeast.
The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A.
The C terminus of hepatitis C virus NS4A encodes an electrostatic switch that regulates NS5A hyperphosphorylation and viral replication.
The C-terminal alpha-helix domain of apolipoprotein E is required for interaction with nonstructural protein 5A and assembly of hepatitis C virus.
The C-terminal hydrophobic domain of hepatitis C virus RNA polymerase NS5B can be replaced with a heterologous domain of poliovirus protein 3A.
The C-terminal transmembrane domain of hepatitis C virus (HCV) RNA polymerase is essential for HCV replication in vivo.
The conserved lysine 151 of HCV NS5B modulates viral genome replication and infectious virus production.
The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus: a dual function target for common cold antiviral therapy.
The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus.
The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine.
The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine.
The discovery and structure-activity relationships of pyrano[3,4-b]indole based inhibitors of hepatitis C virus NS5B polymerase.
The discovery and structure-activity relationships of pyrano[3,4-b]indole-based inhibitors of hepatitis C virus NS5B polymerase.
The discovery of finger loop inhibitors of the hepatitis C virus NS5B polymerase: status and prospects for novel HCV therapeutics.
The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile-Part?1.
The Disordered Region of the HCV Protein NS5A: Conformational Dynamics, SH3 Binding, and Phosphorylation.
The Effect of Mild to Moderate Renal Impairment on the Pharmacokinetics of the Nucleoside Analog Hepatitis C Virus Polymerase Inhibitor Mericitabine.
The essential role of C-terminal residues in regulating the activity of hepatitis C virus RNA-dependent RNA polymerase.
The exploding field of the HCV polymerase non-nucleoside inhibitors: summary of a first generation compounds.
The HCV NS5B Nucleoside and Non-Nucleoside Inhibitors.
The hepatitis C viral nonstructural protein 5A stabilizes growth-regulatory human transcripts.
The hepatitis C virus core protein can modulate RNA-dependent RNA synthesis by the 2a polymerase.
The Hepatitis C Virus NS5A Stimulates NS5B During In Vitro RNA Synthesis in a Template Specific Manner.
The hepatitis C virus NS5B RNA-dependent RNA polymerase activity and susceptibility to inhibitors is modulated by metal cations.
The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleoside polymerase or protease inhibitors.
The hepatitis C virus RNA-dependent RNA polymerase directs incoming nucleotides to its active site through magnesium-dependent dynamics within its F motif.
The hepatitis C virus RNA-dependent RNA polymerase membrane insertion sequence is a transmembrane segment.
The juxtamembrane sequence of the Hepatitis C virus polymerase can affect RNA synthesis and inhibition by allosteric polymerase inhibitors.
The Long-Term Effect of Hepatitis C Virus on the Outcome of Live-Donor Kidney Transplant Recipients. A Retrospective Study.
The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection.
The non-structural 5A protein of hepatitis C virus.
The nonstructural NS5A protein of hepatitis C virus: an expanding, multifunctional role in enhancing hepatitis C virus pathogenesis.
The prevalence of hepatitis C in survivors of paediatric malignancy.
The protease inhibitor, GS-9256, and non-nucleoside polymerase inhibitor tegobuvir alone, with ribavirin, or pegylated interferon plus ribavirin in hepatitis C.
The RNA-dependent RNA polymerases of different members of the family Flaviviridae exhibit similar properties in vitro.
The Stimulatory Mechanism of Hepatitis C Virus NS5A Protein on the NS5B Catalyzed Replication Reaction In Vitro.
The successful immune response against hepatitis C nonstructural protein 5A (NS5A) requires heterologous DNA/protein immunization.
The synthesis and evaluation of a novel class of (E)-3-(1-cyclohexyl-1H-pyrazol-3-yl)-2-methylacrylic acid hepatitis C virus polymerase NS5B inhibitors.
The Viral Polymerase Inhibitor 2'-C-Methylcytidine Inhibits Norwalk Virus Replication and Protects against Norovirus-Induced Diarrhea and Mortality in a Mouse Model.
Therapy of hepatitis C: other options.
Thumb inhibitor binding eliminates functionally important dynamics in the hepatitis C virus RNA polymerase.
Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-Dependent RNA Polymerase Allosterically Block the Transition from Initiation to Elongation.
Time to viral suppression is not related to achievement of SVR12 in HCV GT1-infected patients treated with ombitasvir/paritaprevir/ritonavir and dasabuvir with or without ribavirin.
Tissue hepatitis C virus RNA quantification and protein expression help identify early hepatitis C virus recurrence after liver transplantation.
TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage.
Transfection and expression of HCV-NS5B gene in Huh-7 cells.
Treatment of hepatitis C virus infection.
Treatment Options in Hepatitis C.
Two crucial early steps in RNA synthesis by the hepatitis C virus polymerase involve a dual role of residue 405.
Two RNA tunnel inhibitors bind in highly conserved sites in Dengue virus NS5 polymerase: structural and functional studies.
Ubiquitin ligase Fbw7 restricts the replication of hepatitis C virus by targeting NS5B for ubiquitination and degradation.
Understanding effect site pharmacology of uprifosbuvir, a hepatitis C virus nucleoside inhibitor: Case study of a multidisciplinary modeling approach in drug development.
Understanding the drug resistance mechanism of hepatitis C virus NS5B to PF-00868554 due to mutations of the 423 site: a computational study.
Understanding the mechanisms of viral RNA synthesis: towards the discovery of new inhibitors.
Update on hepatitis C virus resistance to direct-acting antiviral agents.
Using the Hepatitis C Virus RNA-Dependent RNA Polymerase as a Model to Understand Viral Polymerase Structure, Function and Dynamics.
Validation and Application of a Liquid Chromatography-Tandem Mass Spectrometry Method To Determine the Concentrations of Sofosbuvir Anabolites in Cells.
VAPC, an Human Endogenous Inhibitor for Hepatitis C Virus (HCV) Infection, Is Intrinsically Unstructured but Forms a "Fuzzy Complex" with HCV NS5B.
Variability of the polymerase gene (NS5B) in hepatitis C virus-infected women.
Variations of hepatitis C virus NS5B sequence (nucleotides 8261-8566) do not correlate with response to interferon-alpha therapy.
Vinexin ? Interacts with Hepatitis C Virus NS5A, Modulating Its Hyperphosphorylation To Regulate Viral Propagation.
Viral double-strand RNA-binding proteins can enhance innate immune signaling by toll-like Receptor 3.
Viral factors influencing the response to the combination therapy of peginterferon plus ribavirin in chronic hepatitis C.
Viral load is associated with abnormal serum levels of micronutrients and glutathione and glutathione-dependent enzymes in genotype 3 HCV patients.
Viral replication. Structural basis for RNA replication by the hepatitis C virus polymerase.
Viral targets of acylguanidines.
Viral, host and interferon-related factors modulating the effect of interferon therapy for hepatitis C virus infection.
Virologic escape in HCV genotype 1-infected patients receiving daclatasvir plus ribavirin and peginterferon alfa-2a or alfa-2b.
VX-222, a non-nucleoside NS5B polymerase inhibitor, in telaprevir-based regimens for genotype 1 hepatitis C virus infection.
Water-soluble Fullerene Derivatives for Drug Discovery.
West Nile virus strain Kunjin NS5 polymerase is a phosphoprotein localized at the cytoplasmic site of viral RNA synthesis.
Worldwide distribution of the NS3 gene 80K polymorphism among circulating hepatitis C genotype 1 viruses: implication for simeprevir usage.
[2'fluoro derivatives of nucleosides as substrates of viral replicative nucleotide polymerases].
[Active components of Ligustrum lucidum inhibiting hepatitis C virus replicase activity].
[Cloning and expressing of HCV NS5 partial gene and dynamic changes of anti-NS5]
[Cloning of genes transactivated by nonstructural protein 4A of hepatitis C virus.]
[Crystal structure of hepatitis C virus NS5B polymerase]
[Effect of hepatitis C virus nonstructural protein 5A and its domains II on hepatocyte gluconeogenesis in mice].
[Expression of a HCV multi-epitopes antigen gene and study on its immunogenicity]
[Future perspective in the treatment of chronic hepatitis C].
[HCV NS5A protein down-regulates hepcidin gene expression and increases hepatic intracellular iron storage].
[Hepatitis C virus NS5A protein upregulates survivin gene expression]
[Interferon resistance and ISDR (interferon sensitivity determining region)]
[Involvement of nonstructural protein 5A and lipids on production of hepatitis C virus particles]
[Molecular evolutionary analysis of GB viruses and hepatitis G virus]
[Non-hydrolysable analogs of inorganic pyrophopshate as inhibitors of hepatitis C virus RNA-dependent RNA-polymerase].
[Polymerase chain reaction in hepatitis C: increased sensitivity via amplification of shorter cDNA fragments]
[Serological study of hepatitis C virus NS5 protein epitopes and their clinical and diagnostic significance]
[Significance of hepatitis C virus baseline polymorphism during the antiviral therapy].
[Study of the subcellular location of the human gene 6 transactivated by nonstructeral protein 5a of hepatitis C virus]
[The effect of Hepatitis C virus nonstructural protein 5A on cell cycling]
[Transfection and expression of HCV-NS(5)B gene in Huh-7 cells]
[Use of synthetic peptides as additional antigens for detecting antibodies to hepatitis C virus]
Hepatitis C, Chronic
Advances in drug development for hepatitis C.
Analysis of Naturally Occurring Resistance-Associated Variants to NS3/4A Protein Inhibitors, NS5A Protein Inhibitors, and NS5B Polymerase Inhibitors in Patients With Chronic Hepatitis C.
Antiviral Effect, Safety, and Pharmacokinetics of Five-Day Oral Administration of Deleobuvir (BI 207127), an Investigational Hepatitis C Virus RNA Polymerase Inhibitor, in Patients with Chronic Hepatitis C.
Assessment of hepatitis C virus RNA levels by quantitative competitive RNA polymerase chain reaction: high-titer viremia correlates with advanced stage of disease.
Benefit-risk assessment for sofosbuvir/velpatasvir/voxilaprevir based on patient population and hepatitis C virus genotype: U. S. Food and Drug Administration's evaluation.
Changing the face of hepatitis C management - the design and development of sofosbuvir.
Clinical Pharmacokinetics and Pharmacodynamics of Ledipasvir/Sofosbuvir, a Fixed-Dose Combination Tablet for the Treatment of Hepatitis C.
Daclatasvir combined with sofosbuvir or simeprevir in liver transplant recipients with severe recurrent hepatitis C infection.
Drug-Drug Interaction Profile of the Fixed-Dose Combination Tablet Regimen Ledipasvir/Sofosbuvir.
Effect of mutation in the hepatitis C virus nonstructural 5B region on HCV replication.
Factors predictive of sustained virological response following 72 weeks of combination therapy for genotype 1b hepatitis C.
Fixed-dose combination of sofosbuvir and ledipasvir for the treatment of chronic hepatitis C genotype 1.
Glecaprevir/pibrentasvir for the treatment of chronic hepatitis C virus infection in adults.
GSK2878175, a pan-genotypic non-nucleoside NS5B polymerase inhibitor, in healthy and treatment-naïve chronic hepatitis C subjects.
HCV replication in PBMC and its influence on interferon therapy.
Identification of beta-subunit of bacterial RNA-polymerase--a non-species-specific bacterial protein--as target of antibodies in primary biliary cirrhosis.
Immune response to a hepatitis C virus nonstructural protein in chronic hepatitis C virus infection.
Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa.
Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection.
Mutations in the nonstructural protein 5A gene and response to interferon therapy in young patients with chronic hepatitis C virus 1b infection.
Naturally occurring mutations associated with resistance to HCV NS5B polymerase and NS3 protease inhibitors in treatment-naïve patients with chronic hepatitis C.
New Non-Nucleocide NS5B Protein Inhibitors for the Treatment of Chronic Hepatitis C Infection.
Nonstructural Protein 5A (NS5A) Resistance Profile in Patients with Chronic Hepatitis C Treated with Ledipasvir-Containing Regimens Without Sofosbuvir.
Ombitasvir/Paritaprevir/Ritonavir Plus Dasabuvir: A Review in Chronic HCV Genotype 1 Infection.
Pharmacokinetics of hepatitis C virus NS5A inhibitor JNJ-56914845 (GSK2336805) in subjects with hepatic impairment.
Polymorphisms of NS5B protein relates to early clearance of hepatitis C virus by interferon plus ribavirin: a pilot study.
Real-world effectiveness and safety of sofosbuvir and nonstructural protein 5A inhibitors for chronic hepatitis C genotype 1, 2, 3, 4, or 6: a multicentre cohort study.
Retreatment of chronic hepatitis C virus genotype-4 patients after non-structural protein 5A inhibitors' failure: efficacy and safety of different regimens.
Review article: the efficacy and safety of sofosbuvir, a novel, oral nucleotide NS5B polymerase inhibitor, in the treatment of chronic hepatitis C virus infection.
Ribavirin mode of action in chronic hepatitis C: from clinical use back to molecular mechanisms.
SAR study of bisamides as cyclophilin a inhibitors for the development of host-targeting therapy for hepatitis C virus infection.
Serum hepatitis C virus RNA levels in chronic hepatitis C--importance for outcome of interferon alfa-2b treatment.
Sofosbuvir/velpatasvir fixed-dose combination for the treatment of chronic hepatitis C virus infection.
Sofosbuvir: first global approval.
Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C.
The presence of resistance mutations to protease and polymerase inhibitors in Hepatitis C virus sequences from the Los Alamos databank.
Therapy of hepatitis C: other options.
Use and interpretation of HCV diagnostic tests in the clinical setting.
Hepatitis E
A mutation in the hepatitis E virus RNA polymerase promotes its replication and associates with ribavirin treatment failure in organ transplant recipients.
A novel mycovirus that is related to the human pathogen hepatitis E virus and rubi-like viruses.
Chronic hepatitis E in a heart transplant patient: sofosbuvir and ribavirin regimen not fully effective.
Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses.
Deubiquitination activity associated with hepatitis E virus putative papain-like cysteine protease.
Effective inhibition of hepatitis E virus replication in A549 cells and piglets by RNA interference (RNAi) targeting RNA-dependent RNA polymerase.
Expression and processing of the Hepatitis E virus ORF1 nonstructural polyprotein.
First Crystal Structure of a Nonstructural Hepatitis E Viral Protein Identifies a Putative Novel Zinc-Binding Protein.
Hepatitis E virus (HEV): strain variation in the nonstructural gene region encoding consensus motifs for an RNA-dependent RNA polymerase and an ATP/GTP binding site.
Hepatitis E virus ORF1 encoded non structural protein-host protein interaction network.
Hepatitis E virus RNA dependent RNA polymerase: RNA template specificities, recruitment and synthesis.
Hepatitis E Virus RNA-Dependent RNA Polymerase is Involved in RNA Replication and Infectious Particle Production.
Human linear B-cell epitopes encoded by the hepatitis E virus include determinants in the RNA-dependent RNA polymerase.
Identification and genetic characterization of a porcine hepe-astrovirus (bastrovirus) in the United States.
Identification of genetic diversity of hepatitis E virus (HEV) and determination of the seroprevalence of HEV in eastern China.
Molecular characterization of a hepatitis E virus isolate from Namibia.
Partial sequence comparison of eight new Chinese strains of hepatitis E virus suggests the genome sequence is relatively stable.
Phylogenetic analysis of hepatitis E virus isolates from India (1976-1993).
Ribavirin for Hepatitis E Virus Infection After Organ Transplantation: A Large European Retrospective Multicenter Study.
RNA-dependent RNA Polymerase Assay for Hepatitis E Virus.
The 3' end of hepatitis E virus (HEV) genome binds specifically to the viral RNA-dependent RNA polymerase (RdRp).
The Lysine Residues within the Human Ribosomal Protein S17 Sequence Naturally Inserted into the Viral Nonstructural Protein of a Unique Strain of Hepatitis E Virus Are Important for Enhanced Virus Replication.
Zinc salts block Hepatitis E virus replication by inhibiting the activity of viral RNA-dependent RNA polymerase.
Hepatitis, Autoimmune
Identification of beta-subunit of bacterial RNA-polymerase--a non-species-specific bacterial protein--as target of antibodies in primary biliary cirrhosis.
Hepatitis, Chronic
Construction and characterization of Genotype-3 hepatitis C virus replicon revealed critical genotype-3-specific polymorphism for drug resistance and viral fitness.
Liver histology in anti-HCV-positive persons with normal or minimally elevated aminotransferases.
M2 Macrophages Play Critical Roles in Progression of Inflammatory Liver Disease in Hepatitis C Virus Transgenic Mice.
Ribavirin for Hepatitis E Virus Infection After Organ Transplantation: A Large European Retrospective Multicenter Study.
Herpes Simplex
A combination microbicide gel protects macaques against vaginal simian human immunodeficiency virus-reverse transcriptase infection, but only partially reduces herpes simplex virus-2 infection after a single high-dose cochallenge.
Binding of herpes simplex virus-1 US11 to specific RNA sequences.
Characterization of the herpes simplex virus (HSV)-1 tegument protein VP1-2 during infection with the HSV temperature-sensitive mutant tsB7.
Conserved Outer Tegument Component UL11 from Herpes Simplex Virus 1 Is an Intrinsically Disordered, RNA-Binding Protein.
Distinct domains in herpes simplex virus type 1 US11 protein mediate post-transcriptional transactivation of human T-lymphotropic virus type I envelope glycoprotein gene expression and specific binding to the Rex responsive element.
Emerging antiviral drugs.
Evidence that herpes simplex virus DNA is transcribed by cellular RNA polymerase B.
Herpes simplex virus 1 RNA-binding protein US11 negatively regulates the accumulation of a truncated viral mRNA.
Identification of an export control sequence and a requirement for the KH domains in ICP27 from herpes simplex virus type 1.
In vitro transcription of herpes simplex virus ANG DNA by E-coli RNA polymerase.
In vitro transcription of herpes simplex virus genes. Partial purification and properties of RNA polymerase II from uninfected and infected Hep-2 cells.
Inhibition of hepatitis B virus DNA polymerase by enantiomers of penciclovir triphosphate and metabolic basis for selective inhibition of HBV replication by penciclovir.
Intercellular trafficking activity of herpes simplex virus US11 gene product in the mouse brain.
Nucleotide sequence of a 55 kbp region from the right end of the genome of a pathogenic African swine fever virus isolate (Malawi LIL20/1).
Release of RNA polymerase from vero cell mitochondria after herpes simplex virus type 1 infection.
RNA polymerase III and antiviral innate immune response.
Structure and function in the herpes simplex virus 1 RNA-binding protein U(s)11: mapping of the domain required for ribosomal and nucleolar association and RNA binding in vitro.
Suppression of PACT-induced type I interferon production by herpes simplex virus type 1 Us11 protein.
The antiviral activity of tetrazole phosphonic acids and their analogues.
The Epstein-Barr virus SM protein is functionally similar to ICP27 from herpes simplex virus in viral infections.
The herpes simplex virus UL37 protein is phosphorylated in infected cells.
The herpes simplex virus Us11 open reading frame encodes a sequence-specific RNA-binding protein.
Variation of DNA polymerase and RNA polymerase activities in cells infected with herpes simplex virus type 1.
Herpes Zoster
RNA polymerase III and antiviral innate immune response.
Herpesviridae Infections
Approved Antiviral Drugs over the Past 50 Years.
Histiocytosis
The Expression of Insulin-Like Growth Factor 2 Messenger RNA-Binding Protein 3 in Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma.
Histiocytosis, Langerhans-Cell
The Expression of Insulin-Like Growth Factor 2 Messenger RNA-Binding Protein 3 in Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma.
HIV Infections
Acute HIV Infection in Youth: Protocol for the Adolescent Trials Network 147 (ATN147) Comprehensive Adolescent Research and Engagement Studies (CARES) Study.
Approved Antiviral Drugs over the Past 50 Years.
Clinical Versus Rapid Molecular HIV Diagnosis in Hospitalized African Infants: A Randomized Controlled Trial Simulating Point-of-Care Infant Testing.
Column selection and method development for the determination of the enantiomeric purity of investigational non-nucleoside reverse transcriptase inhibitors.
Efavirenz or nevirapine in three-drug combination therapy with two nucleoside or nucleotide-reverse transcriptase inhibitors for initial treatment of HIV infection in antiretroviral-naïve individuals.
Efavirenz or nevirapine in three-drug combination therapy with two nucleoside-reverse transcriptase inhibitors for initial treatment of HIV infection in antiretroviral-naïve individuals.
Emerging antiviral drugs.
Estimation of the timing of perinatal transmission of HIV.
Highlights in the development of new antiviral agents.
Impact of protease inhibitor therapy on HIV-related oropharyngeal candidiasis.
[Clinical indications for resistance testing HIV infection].
[Drug clinics. How I treat HIV infections. II. Nucleoside reverse transcriptase inhibitors]
[Pharma-clinics. How I treat ... HIV infection. III. Non-nucleoside reverse transcriptase inhibitors]
[Treatment of HIV infection in clinical practice. Wide-range genotypic resistance to all nucleoside analogues and protease inhibitors, and severe intolerance to all non-nucleoside inhibitors of inverse transcriptase]
HIV Seropositivity
Acute HIV Infections among Men with Genital Ulcer Disease in South Africa.
Huntington Disease
FUS/TLS as a polyglutamine aggregate interacting protein.
Pathogenic SREK1 decrease in Huntington's disease lowers TAF1 mimicking X-linked dystonia parkinsonism.
RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells.
The RNA-binding protein FUS/TLS is a common aggregate-interacting protein in polyglutamine diseases.
Hyperalgesia
Silencing of the RNA-binding protein HuR attenuates hyperalgesia and motor disability in experimental autoimmune encephalomyelitis.
Hyperlipidemias
[Hyperlipidemia and glucose intolerance in patients with HIV infection receiving antiretroviral therapy]
Hyperparathyroidism
Loss of expression for the Wnt pathway components adenomatous polyposis coli and glycogen synthase kinase 3-beta in parathyroid carcinomas.
Hypersensitivity
A Screen for rfaH Suppressors Reveals a Key Role for a Connector Region of Termination Factor Rho.
Expression in cattle of epitopes of a heterologous virus using a recombinant rinderpest virus.
Functions that protect Escherichia coli from DNA-protein crosslinks.
Insights into how innocuous foods or proteins deserving of immune ignorance can become allergens.
Integration host factor activates the Ner-repressed early promoter of transposable Mu-like phage D108.
Mitochondrial RNA polymerase of Saccharomyces cerevisiae: composition and mechanism of promoter recognition.
Mutations in the ss subunit of the Bacillus subtilis RNA polymerase that confer both rifampicin resistance and hypersensitivity to NusG.
Passage of RNA polymerase from open complex to elongation mode at the Escherichia coli lacUV5 promoter: nucleolytic hypersensitivity as a probe for complex conformational changes.
Separate mechanisms are involved in rifampicin upmodulated and downmodulated gene expression in Salmonella Typhimurium.
Spinal RyR2 pathway regulated by the RNA-binding protein HuD induces pain hypersensitivity in antiretroviral neuropathy.
Systematic enrichment analysis of potentially functional regions for 103 prostate cancer risk-associated loci.
[Correlation, in previously treated HIV-1 positive patients, between hypersensitivity reaction to abacavir and the presence of the HLA-B*5701 allele.]
Hypertension
Deficiency of cold-inducible RNA-binding protein exacerbated monocrotaline-induced pulmonary artery hypertension through Caveolin1 and CAVIN1.
The Role of PB1 Domain Proteins in Endothelial Cell Dysfunction and Disease.
Hypertension, Portal
Non-cirrhotic portal hypertension in HIV mono-infected patients.
Hyperthyroidism
Triiodothyronine effects on RNA polymerase activities in isolated neuronal and glial nuclei of the mature rat brain cortex.
Hypogonadism
Endocrine Aspects of 4H Leukodystrophy: A Case Report and Review of the Literature.
Hyponatremia
Incidence and predictive factors of transaminase elevation in patients consulting for dengue fever in Cayenne Hospital, French Guiana.
Hypothyroidism
Mitochondrial DNA, RNA and protein synthesis in normal and hypothyroid developing rat liver.
Idiopathic Interstitial Pneumonias
The long-term outcome of interstitial lung disease with anti-aminoacyl-tRNA synthetase antibodies.
Idiopathic Pulmonary Fibrosis
Clinical Significance of Cold-Inducible RNA-Binding Protein in Idiopathic Pulmonary Fibrosis.
Immune Reconstitution Inflammatory Syndrome
Cutaneous toxicities of antiretroviral therapy for HIV: part II. Nonnucleoside reverse transcriptase inhibitors, entry and fusion inhibitors, integrase inhibitors, and immune reconstitution syndrome.
Infections
'Drc', a structurally novel ssDNA-binding transcription regulator of N4-related bacterial viruses.
1918 HA and the viral RNA polymerase complex enhance viral pathogenicity, but only HA induces aberrant host responses in mice.
?, a new subunit of RNA polymerase found in gram-positive bacteria.
A Bunyavirus-Inducible Ubiquitin Ligase Targets RNA Polymerase IV for Degradation during Viral Pathogenesis in Rice.
A combination microbicide gel protects macaques against vaginal simian human immunodeficiency virus-reverse transcriptase infection, but only partially reduces herpes simplex virus-2 infection after a single high-dose cochallenge.
A fatal case report of antibody-dependent enhancement of dengue virus type 1 following remote Zika virus infection.
A genome-linked copy of the NS-1 polypeptide is located on the outside of infectious parvovirus particles.
A high-throughput assay using dengue-1 virus-like particles for drug discovery.
A natural variant of a host RNA-dependent RNA polymerase is associated with increased susceptibility to viruses by Nicotiana benthamiana.
A necrosis-inducing elicitor domain encoded by both symptomatic and asymptomatic Plantago asiatica mosaic virus isolates, whose expression is modulated by virus replication.
A non-canonical multisubunit RNA polymerase encoded by a giant bacteriophage.
A novel bi-functional DNA vaccine expressing VP1 protein and producing antisense RNA targeted to 5'UTR of foot-and-mouth disease virus can induce both rapid inhibitory effect and specific immune response in mice.
A novel type of paramyxovirus found in Hungary in a masked water snake (Homalopsis buccata) with pneumonia supports the suggested new taxonomy within the Ferlavirus genus.
A phase 3b study of sofosbuvir plus ribavirin in Taiwanese patients with chronic genotype 2 hepatitis C virus infection.
A promising antiviral candidate drug for the COVID-19 pandemic: A mini-review of remdesivir.
A quantitative high-resolution genetic profile rapidly identifies sequence determinants of hepatitis C viral fitness and drug sensitivity.
A retrospective case-control study of hepatitis C virus infection and oral lichen planus in Japan: association study with mutations in the core and NS5A region of hepatitis C virus.
A Scoping Insight on Potential Prophylactics, Vaccines and Therapeutic Weaponry for the Ongoing Novel Coronavirus (COVID-19) Pandemic- A Comprehensive Review.
A shift in plant proteome profile for a Bromodomain containing RNA binding Protein (BRP1) in plants infected with Cucumber mosaic virus and its satellite RNA.
A simple cell-based high throughput screening (HTS) assay for inhibitors of Salmonella enterica RNA polymerase containing the general stress response regulator RpoS (?S).
A simple method of distinguishing the bacterial viruses T3 and T7, and a critical reevaluation of their heterologous and homologous exclusion.
A Single ssRNA Segment Encoding RdRp Is Sufficient for Replication, Infection, and Transmission of Ourmia-Like Virus in Fungi.
A transmissible human endogenous retrovirus.
A validated LC-MS/MS method for the simultaneous determination of BMS-791325, a hepatitis C virus NS5B RNA polymerase inhibitor, and its metabolite in plasma.
A25?Phylogenetic analysis of the nucleocapsid and RNA-dependent RNA polymerase fragments of the first imported case of middle east respiratory syndrome coronavirus (MERS-CoV) infection in the Philippines from Saudi Arabia, February 2015.
Abortive infection of a rabbit cornea cell line by vesicular stomatitis virus: conversion to productive infection by superinfection with vaccinia virus.
Absence of a gene dosage effect during bacteriophage T3- and T7-coded RNA polymerase synthesis.
Accumulation of 24 nucleotide transgene-derived siRNAs is associated with crinivirus immunity in transgenic plants.
Accurate serodiagnosis of B19 parvovirus infections by measurement of IgG avidity.
Activation of Tomato bushy stunt virus RdRp by cellular Hsp70 is enhanced by phospholipids in vitro.
Acute hepatitis E infection associated with a false-positive serology against Epstein-Barr virus.
Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2 alpha kinase.
Adenovirus VAI RNA prevents phosphorylation of the eukaryotic initiation factor 2 alpha subunit subsequent to infection.
Advances in drug development for hepatitis C.
An adenovirus mutant unable to express VAI RNA displays different growth responses and sensitivity to interferon in various host cell lines.
An attenuating mutation in nsP1 of the Sindbis-group virus S.A.AR86 accelerates nonstructural protein processing and up-regulates viral 26S RNA synthesis.
An E. coli B mutation, rpoB5081, that prevents growth of phage T4 strains defective in host DNA degradation.
An interferon-free antiviral regimen for HCV after liver transplantation.
An RNA polymerase II transcription factor inactivated in poliovirus-infected cells copurifies with transcription factor TFIID.
Analysis of Dengue Virus Genetic Diversity during Human and Mosquito Infection Reveals Genetic Constraints.
Analysis of mutant NS5B proteins encoded by isolates from chimpanzees chronically infected following clonal HCV RNA inoculation.
Andrographolide binds to spike glycoprotein and RNA-dependent RNA polymerase (NSP12) of SARS-CoV-2 by in silico approach: a probable molecule in the development of anti-coronaviral drug.
Anti-TMV activity and functional mechanisms of two sesquiterpenoids isolated from Tithonia diversifolia.
Anti-viral mechanism of barramundi Mx against betanodavirus involves the inhibition of viral RNA synthesis through the interference of RdRp.
Antibodies against West Nile Virus nonstructural protein NS1 prevent lethal infection through Fc gamma receptor-dependent and -independent mechanisms.
Antibodies to foot-and-mouth disease virus infection associated (VIA) antigen: use of a bioengineered VIA protein as antigen in an ELISA.
Antibodies to the nonstructural protein of parvovirus B19 in persistently infected patients: implications for pathogenesis.
Antibodies to the Novel Human Pegivirus 2 Are Associated with Active and Resolved Infections.
Antibody to the nonstructural protein NS1 of Japanese encephalitis virus: potential application of mAb-based indirect ELISA to differentiate infection from vaccination.
Antiviral action of nitric oxide on dengue virus type 2 replication.
Antiviral Effects of a Transgenic RNA-Dependent RNA-Polymerase.
Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity.
Antiviral treatment of hepatitis C: present status and future prospects.
ANXA2 Facilitates Enterovirus 71 Infection by Interacting with 3D Polymerase and PI4KB to Assist the Assembly of Replication Organelles.
Apoptosis of liver-derived cells induced by parvovirus B19 nonstructural protein.
Approved Antiviral Drugs over the Past 50 Years.
Arabidopsis RNA Polymerase V Mediates Enhanced Compaction and Silencing of Geminivirus and Transposon Chromatin during Host Recovery from Infection.
Assembly of Bacillus subtilis phage phe29. 2. Mutants in the cistrons coding for the non-structural proteins.
Assembly of viroplasms by viral nonstructural protein Pns9 is essential for persistent infection of rice gall dwarf virus in its insect vector.
Assessment of Sep1virus interaction with stationary cultures by transcriptional and flow cytometry studies.
Autophagy enhances the replication of classical swine fever virus in vitro.
Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infection.
Avian reovirus major mu-class outer capsid protein influences efficiency of productive macrophage infection in a virus strain-specific manner.
B-cell responses during primary and secondary dengue virus infections in humans.
B19 parvovirus.
Bacteriophage SP6-specific RNA polymerase. I. Isolation and characterization of the enzyme.
Baculovirus late expression factors.
Baculovirus-expressed nonstructural protein NS2 of bluetongue virus induces a cytotoxic T-cell response in mice which affords partial protection.
Benefit-risk assessment for sofosbuvir/velpatasvir/voxilaprevir based on patient population and hepatitis C virus genotype: U. S. Food and Drug Administration's evaluation.
Binding of the bacteriophage T4 transcriptional activator, MotA, to T4 middle promoter DNA: evidence for both major and minor groove contacts.
Biochemical activities of minute virus of mice nonstructural protein NS1 are modulated In vitro by the phosphorylation state of the polypeptide.
BKV and JCV large T antigen-specific CD8+ T cell response in HLA A*0201+ kidney transplant recipients with polyomavirus nephropathy and patients with progressive multifocal leukoencephalopathy.
Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism.
Bombyx mori nucleopolyhedrovirus lef8 gene: effects of deletion and implications for gene transduction applications.
Borrelia burgdorferi erpT expression in the arthropod vector and murine host.
BPR-3P0128 inhibits RNA-dependent RNA polymerase elongation and VPg uridylylation activities of Enterovirus 71.
Cardiovirus 2A protein associates with 40S but not 80S ribosome subunits during infection.
Cascade regulation of vaccinia virus gene expression is modulated by multistage promoters.
Cathelicidin antimicrobial peptides suppress EV71 infection via regulating antiviral response and inhibiting viral binding.
Cellular vimentin regulates construction of dengue virus replication complexes through interaction with NS4A protein.
Chagas Disease in Southern Coastal Ecuador: Coinfections with Arboviruses and a Comparison of Serological Assays for Chagas Disease Diagnosis.
Changes in the proteome of pad2-1, a glutathione depleted Arabidopsis mutant, during Pseudomonas syringae infection.
Characteristics of human infection with avian influenza viruses and development of new antiviral agents.
Characteristics of siRNAs derived from Southern rice black-streaked dwarf virus in infected rice and their potential role in host gene regulation.
Characterization of a 7-kilodalton subunit of vaccinia virus DNA-dependent RNA polymerase with structural similarities to the smallest subunit of eukaryotic RNA polymerase II.
Characterization of a monoclonal antibody against the 3D polymerase of enterovirus 71 and its use for the detection of human enterovirus A infection.
Characterization of a Sugar-O-methyltransferase TiaS5 Affords New Tiacumicin Analogues with Improved Antibacterial Properties and Reveals Substrate Promiscuity.
Characterization of an enteropathogenic bovine calicivirus representing a potentially new calicivirus genus.
Characterization of In vitro inhibitory effects of consensus short interference RNAs against non-structural 5B gene of hepatitis C virus 1a genotype.
Characterization of pre-transcription complexes made at a bacteriophage T4 middle promoter: involvement of the T4 MotA activator and the T4 AsiA protein, a sigma 70 binding protein, in the formation of the open complex.
Characterization of Resistance to the Nonnucleoside NS5B Inhibitor Filibuvir in Hepatitis C Virus-Infected Patients.
Characterization of the infectivity of Bamboo mosaic virus with its correlation to the in vitro replicase activities in Nicotiana benthamiana.
Characterization of the interaction between the influenza A virus polymerase subunit PB1 and the host nuclear import factor Ran-binding protein 5.
Characterization of tubular structures composed of nonstructural protein NS1 of African horsesickness virus expressed in insect cells.
Characterization of two RNA polymerase activities induced by mouse hepatitis virus.
Chronic hepatitis E in a heart transplant patient: sofosbuvir and ribavirin regimen not fully effective.
Chutes and ladders in hepatitis C nucleoside drug development.
Citrus tristeza virus co-opts glyceraldehyde 3-phosphate dehydrogenase for its infectious cycle by interacting with the viral-encoded protein p23.
Citrus tristeza virus: Host RNA Silencing and Virus Counteraction.
Clinical and Laboratory Diagnosis of Dengue Virus Infection.
Clinical diagnosis of early dengue infection by novel one-step multiplex real-time RT-PCR targeting NS1 gene.
Clinical Pharmacokinetics of Ombitasvir.
CNOT4-Mediated Ubiquitination of Influenza A Virus Nucleoprotein Promotes Viral RNA Replication.
Coexistence of multiple coronaviruses in several bat colonies in an abandoned mineshaft.
Combination of Nonstructural Protein 1-Based Enzyme-Linked Immunosorbent Assays Can Detect and Distinguish Various Dengue Virus and Zika Virus Infections.
Combination of pharmacophore hypothesis and molecular docking to identify novel inhibitors of HCV NS5B polymerase.
Comparative Evaluation of Tears and Nasopharyngeal Swab for SARS-CoV-2 in COVID-19 Dedicated Intensive Care Unit Patients.
Comparison of turnip crinkle virus RNA-dependent RNA polymerase preparations expressed in Escherichia coli or derived from infected plants.
Comparison of two commercially available dengue virus (DENV) NS1 capture enzyme-linked immunosorbent assays using a single clinical sample for diagnosis of acute DENV infection.
Compensatory mutations restore the replication defects caused by cytotoxic T lymphocyte escape mutations in hepatitis C virus polymerase.
Competition between wild-type virus and a reassortant from subgroups I and II of CMV and activation of antiviral responses in cowpea.
Comprehensive analysis of full genome sequence and Bd-milRNA/target mRNAs to discover the mechanism of hypovirulence in Botryosphaeria dothidea strains on pear infection with BdCV1 and BdPV1.
Comprehensive mapping of common immunodominant epitopes in the west nile virus nonstructural protein 1 recognized by avian antibody responses.
Concomitant proton pump inhibitor use does not reduce the efficacy of elbasvir/grazoprevir: A pooled analysis of 1,322 patients with hepatitis C infection.
Consensus numbering system for the rifampicin resistance-associated rpoB gene mutations in pathogenic mycobacteria.
Construction of gag-chimeric viruses between HIV-1 and SIVmac that are capable of productive multi-cycle infection.
Control of gene transcription in T-even bacteriophages: alterations in RNA polymerase accompanying phage infection.
Conversion of Bacillus subtilis RNA polymerase activity in vitro by a protein induced by phage SP01.
Cooperative effect of the attenuation determinants derived from poliovirus sabin 1 strain is essential for attenuation of enterovirus 71 in the NOD/SCID mouse infection model.
Core RNA Interference Genes Involved in miRNA and Ta-siRNA Biogenesis in Hops and Their Expression Analysis after Challenging with Verticillium nonalfalfae.
Coronavirus Endoribonuclease and Deubiquitinating Interferon Antagonists Differentially Modulate the Host Response during Replication in Macrophages.
Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression.
Correlation between chlamydial infection and autoimmune response: molecular mimicry between RNA polymerase major sigma subunit from Chlamydia trachomatis and human L7.
Correlation of cytokine level with the severity of severe fever with thrombocytopenia syndrome.
Corynebacterium tuberculostearicum, a human skin colonizer, induces the canonical nuclear factor-?B inflammatory signaling pathway in human skin cells.
COVID-19: An Update on Pathogenesis and Treatment.
Coxsackie B virus infection of mice: inoculation by the oral route protects the pancreas from damage, but not from infection.
Critical phosphoprotein elements that regulate polymerase architecture and function in vesicular stomatitis virus.
Currently circulating genotypes of hepatitis E virus in India, 2014-2018.
Currently Circulating Genotypes of Hepatitis E Virus in India, 2014-2018.
CVB3 Nonstructural 2A Protein Modulates SREBP1a Signaling via the MEK/ERK Pathway.
Daclatasvir + asunaprevir + beclabuvir ± ribavirin for chronic HCV genotype 1-infected treatment-naive patients.
Daclatasvir combined with sofosbuvir or simeprevir in liver transplant recipients with severe recurrent hepatitis C infection.
De novo generation of defective interfering-like RNAs in broad bean mottle bromovirus.
De novo synthesis of N and P proteins as a key step in Sendai virus gene expression.
Defining the Utility of a Commercial NS1 Antigen Capture Kit as a Dengue Virus (DENV) Diagnostic Tool.
Dengue fever during pregnancy.
Dengue nonstructural protein 1 antigen in the urine as a rapid and convenient diagnostic test during the febrile stage in patients with dengue infection.
Dengue Nonstructural Protein 1 Maintains Autophagy through Retarding Caspase-Mediated Cleavage of Beclin-1.
Dengue virus non-structural protein 1: a pathogenic factor, therapeutic target, and vaccine candidate.
Dengue virus nonstructural protein NS5 induces interleukin-8 transcription and secretion.
Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination.
Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses.
Denovo designing, retro-combinatorial synthesis, and molecular dynamics analysis identify novel antiviral VTRM1.1 against RNA-dependent RNA polymerase of SARS CoV2 virus.
Design and evaluation of novel tetracyclic benzofurans as palm site allosteric inhibitors of HCV NS5B polymerase.
Designing an effective therapeutic siRNA to silence RdRp gene of SARS-CoV-2.
Detailed phenotypic characterization of five temperature-sensitive mutants in the 22- and 147-kilodalton subunits of vaccinia virus DNA-dependent RNA polymerase.
Detection of a subunit of cellular Pol II within highly purified preparations of RNA polymerase isolated from rabbit poxvirus virions.
Detection of dengue virus nonstructural protein 1 (NS1) by using ELISA as a useful laboratory diagnostic method for dengue virus infection of international travelers.
Detection of enteroviral infection in paraffin-embedded tissue by the RNA polymerase chain reaction technique.
Detection of HCV genome in peripheral blood mononuclear cells of Iranian seropositive and HCV RNA negative in plasma of patients with beta-thalassemia major: Occult HCV infection.
Detection of hepatitis C virus NS5 protein and genome in Chinese carcinoma of the extrahepatic bile duct and its significance.
Detection of the dengue virus NS1 antigen using an enzyme immunoassay.
Detection, identification, and differentiation of sheep pox virus and goat pox virus from clinical cases in Giza Governorate, Egypt.
Determination of the interactome of non-structural protein12 from highly pathogenic porcine reproductive and respiratory syndrome virus with host cellular proteins using high throughput proteomics and identification of HSP70 as a cellular factor for virus replication.
Development of a CRISPR/Cas9 system against ruminant animal brucellosis.
Development of an antigen capture immunoassay based on monoclonal antibodies specific for dengue virus serotype 2 nonstructural protein 1 for early and rapid identification of dengue virus serotype 2 infections.
Development of antibodies to the nonstructural protein NS1 of parvovirus B19 during acute symptomatic and subclinical infection in pregnancy: implications for pathogenesis doubtful.
Development of giant bacteriophage ?KZ is independent of the host transcription apparatus.
Diagnosis of persistent aphthovirus infection and its differentiation from vaccination response in cattle by use of enzyme-linked immunoelectrotransfer blot analysis with bioengineered nonstructural viral antigens.
Diagnosis of Zika virus infection on a nanotechnology platform.
Dicer-2- and Piwi-mediated RNA interference in Rift Valley fever virus-infected mosquito cells.
Difference in susceptibility to MxA protein between a coxsackievirus B1 isolate and prototype, impact of serial cell culture passage.
Differential inductions of RNA silencing among encapsidated double-stranded RNA mycoviruses in the white root rot fungus, Rosellinia necatrix.
Direct detection of circulating hepatitis C virus RNA using probes from the 5' untranslated region.
Disassociation of sigma subunit from RNA polymerase of Xanthomonas oryzae pv. oryzae by phage Xp10 infection.
Discovery of Novel HCV NS5B polymerase inhibitor, 2-(3,4-dimethyl-5,5-dioxidobenzo[e]pyrazolo[4,3-c][1,2]thiazin-2(4H)-yl)-N-(2-fluorobenzyl)acetamide via molecular docking and experimental approach.
Discovery of novel Hepatitis C virus inhibitor targeting multiple allosteric sites of NS5B polymerase.
Discovery of Novel Hepatitis C Virus NS5B Polymerase Inhibitors by Combining Random Forest, Multiple e-Pharmacophore Modeling and Docking.
Discovery of Ubonodin, an Antimicrobial Lasso Peptide Active against Members of the Burkholderia cepacia Complex.
Distinguishing Secondary Dengue Virus Infection From Zika Virus Infection With Previous Dengue by a Combination of 3 Simple Serological Tests.
Diversity of the hepatitis C virus NS5B gene during HIV co-infection.
DNA immunization with Japanese encephalitis virus nonstructural protein NS1 elicits protective immunity in mice.
DNA-dependent RNA polymerase subunits encoded within the vaccinia virus genome.
DnaJ homolog Hdj2 facilitates Japanese encephalitis virus replication.
Downregulation of miR-155-5p facilitates enterovirus 71 replication through suppression of type I IFN response by targeting FOXO3/IRF7 pathway.
Drug Resistance and HCV Coinfection in Former Blood Donors Infected with HIV Type 1 in China.
Dutrebis (lamivudine and raltegravir) for use in combination with other antiretroviral products for the treatment of HIV-1 infection.
Dynamics of viral RNA synthesis during measles virus infection.
Dynamics on multiple timescales in the RNA-directed RNA polymerase from the cystovirus {phi}6.
E2 ubiquitin-conjugating enzyme UBE2L6 promotes Senecavirus A proliferation by stabilizing the viral RNA polymerase.
Early RNAs in SP82- and SP01-infected Bacillus subtilis may be processed.
Effective inhibition of porcine transmissible gastroenteritis virus replication in ST cells by shRNAs targeting RNA-dependent RNA polymerase gene.
Effectiveness and safety of sofosbuvir plus ribavirin for HCV genotype 2 patients 65 and over with or without cirrhosis.
Effects of the RNA-binding protein, KSRP, on innate immune response against Helicobacter pylori infection in mice.
Efficacy and safety of a two-drug direct-acting antiviral agent regimen ruzasvir 180 mg and uprifosbuvir 450 mg for 12 weeks in adults with chronic hepatitis C virus genotype 1, 2, 3, 4, 5 or 6.
Efficacy and safety of sofosbuvir-based therapy for the treatment of chronic hepatitis C in treatment-naïve and treatment-experienced patients.
Efficient In Silico Assay of Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase by Structure-Based Virtual Screening and In Vitro Evaluation.
Efficient inhibition of Escherichia coli RNA polymerase by the bacteriophage T4 AsiA protein requires that AsiA binds first to free sigma70.
Electrical detection of dengue biomarker using egg yolk immunoglobulin as the biological recognition element.
Emerging antiviral drugs.
Encephalomyocarditis virus (EMCV) proteins 2A and 3BCD localize to nuclei and inhibit cellular mRNA transcription but not rRNA transcription.
Encephalomyocarditis virus 2A protein is required for viral pathogenesis and inhibition of apoptosis.
Encephalomyocarditis virus disrupts stress granules, the critical platform for triggering antiviral innate immune responses.
Endogenous grouper and barramundi Mx proteins facilitated the clearance of betanodavirus RNA-dependent RNA polymerase.
Engineering partial resistance to cucumber mosaic virus in tobacco using intrabodies specific for the viral polymerase.
Enhanced cytoplasmic sequestration of the nuclear export receptor CRM1 by NS2 mutations developed in the host regulates parvovirus fitness.
Epitope-blocking enzyme-linked immunosorbent assay to differentiate west nile virus from Japanese encephalitis virus infections in equine sera.
Escherichia coli mutant which restricts T7 bacteriophage has an altered RNA polymerase.
Escherichia coli single-stranded DNA-binding protein is a supercoiled template-dependent transcriptional activator of N4 virion RNA polymerase.
Establishment and characterization of a brain cell line from sea perch, Lateolabrax japonicus.
Ethanolic Extract of Melia Fructus Has Anti-influenza A Virus Activity by Affecting Viral Entry and Viral RNA Polymerase.
Evaluation and Clinical Validation of Two Field-Deployable Reverse Transcription-Insulated Isothermal PCR Assays for the Detection of the Middle East Respiratory Syndrome Coronavirus.
Evaluation of dengue nonstructural protein 1 antigen strip for the rapid diagnosis of patients with dengue infection.
Evaluation of serum antibody responses against the rotavirus nonstructural protein NSP4 in children after rhesus rotavirus tetravalent vaccination or natural infection.
Evaluation of sofosbuvir activity and resistance profile against West Nile virus in vitro.
Evasion of cellular antiviral responses by human cytomegalovirus TRS1 and IRS1.
Evidence for direct involvement of T7 RNA polymerase bacteriophage DNA replication.
Evidence incriminating midges (Diptera: Ceratopogonidae) as potential vectors of Leishmania in Australia.
Evidence of RNA in D loops of intracellular lambda DNA.
Evidence of VP1 of duck hepatitis A type 1 virus as a target of neutralizing antibodies and involving receptor-binding activity.
Evidence that herpes simplex virus DNA is transcribed by cellular RNA polymerase B.
Exploratory study of oral combination antiviral therapy for hepatitis C.
Expression in cattle of epitopes of a heterologous virus using a recombinant rinderpest virus.
Expression of a full-length nonstructural protein NS1 of bluetongue virus serotype 17 in Escherichia coli.
Expression of dengue virus structural proteins and nonstructural protein NS1 by a recombinant vaccinia virus.
Expression of the nonstructural protein NS1 of equine influenza A virus: detection of anti-NS1 antibody in post infection equine sera.
Expression of VP1 protein in the milk of transgenic mice: a potential oral vaccine protects against enterovirus 71 infection.
Factors affecting de novo RNA synthesis and back-priming by the respiratory syncytial virus polymerase.
Factors Contributing to the Antiviral Effectiveness of Tenofovir.
Fidaxomicin: Difimicin; Lipiarmycin; OPT 80; OPT-80; PAR 101; PAR-101.
Filibuvir, a non-nucleoside NS5B polymerase inhibitor for the potential oral treatment of chronic HCV infection.
First Crystal Structure of a Nonstructural Hepatitis E Viral Protein Identifies a Putative Novel Zinc-Binding Protein.
First Report of Bean common mosaic virus Infecting Mungbean (Vigna radiata) in China.
First report of cucurbit chlorotic yellows virus in association with other whitefly-transmitted viruses in squash (Cucurbita pepo) in Georgia.
Fish DDX3X exerts antiviral function against grouper nervous necrosis virus infection.
Fitness Cost of Rifampin Resistance in Neisseria meningitidis: In Vitro Study of Mechanisms Associated with rpoB H553Y Mutation.
Flavivirus Nonstructural Protein NS5 Dysregulates HSP90 to Broadly Inhibit JAK/STAT Signaling.
Flavonoids from Pterogyne nitens Inhibit Hepatitis C Virus Entry.
Frequency of occurrence of HIV-1 dual infection in a Belgian MSM population.
Full shut-off of Escherichia coli RNA-polymerase by T7 phage requires a small phage-encoded DNA-binding protein.
Functional analysis of a cellular microRNA in insect host-ascovirus interaction.
Functional characterization of tumor necrosis factor receptor-associated factor 3 of sea perch (Lateolabrax japonicas) in innate immune.
Functional organization of cytoplasmic inclusion bodies in cells infected by respiratory syncytial virus.
Genetic diversity among pandemic 2009 influenza viruses isolated from a transmission chain.
Genetic Risk Factors for the Development of COVID-19 Coronavirus Infection.
Genetic variation and recombination of RdRp and HSP 70h genes of Citrus tristeza virus isolates from orange trees showing symptoms of citrus sudden death disease.
Genome scale analysis of differential mRNA expression of Helicoverpa zea insect cells infected with a H. armigera baculovirus.
Genomes of parasitic nematodes (Meloidogyne hapla, Meloidogyne incognita, Ascaris suum and Brugia malayi) have a reduced complement of small RNA interference pathway genes: knockdown can reduce host infectivity of M. incognita.
Genomic Characterization of Intron-containing T7-like Phage phiL7 of Xanthomonas campestris.
Genomic Diversity and Evolution of Quasispecies in Newcastle Disease Virus Infections.
Genomic diversity of "Norwalk like viruses" (NLVs): pediatric infections in a Brazilian shantytown.
Genotype 3-hepatitis C virus' last line of defense.
Genotypic analysis of Mycobacterium tuberculosis from medieval human remains.
Genotyping of Cucumber mosaic virus isolates in western New York State during epidemic years: Characterization of an emergent plant virus population.
Grouper Mx confers resistance to nodavirus and interacts with coat protein.
Halting HCV Replication with NS5A Inhibitors and NS5B Polymerase Inhibitors: Effective New Treatments of HCV Infection.
HCV replication in PBMC and its influence on interferon therapy.
HDAC6 Restricts Influenza A Virus by Deacetylation of the RNA Polymerase PA Subunit.
Heat shock protein 70 is necessary for Rice stripe virus infection in plants.
Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding protein.
Hepatitis C virus NS2/3 protease regulates HCV IRES-dependent translation and NS5B RdRp activity.
Hepatitis C virus NS3 inhibitors: current and future perspectives.
Hepatitis C Virus NS5A Protein Promotes the Lysosomal Degradation of Hepatocyte Nuclear Factor 1? via Chaperone-Mediated Autophagy.
Hepatitis C Virus NS5A Targets Nucleosome Assembly Protein NAP1L1 To Control the Innate Cellular Response.
Hepatitis C virus replicates in the same immune cell subsets in chronic hepatitis C and occult infection.
Hepatitis E virus polymerase binds to IFIT1 to protect the viral RNA from IFIT1-mediated translation inhibition.
Heterogeneous Nuclear Ribonucleoprotein M Facilitates Enterovirus Infection.
High-Level Expression of Functionally Active Dengue-2 Non-Structural Antigen 1 Production in Escherichia coli.
Highlights in the development of new antiviral agents.
Highly pathogenic avian influenza viruses do not inhibit interferon synthesis in infected chickens but can override the interferon-induced antiviral state.
Highly purified cucumber mosaic virus-induced RNA-dependent RNA polymerase does not contain any of the full length translation products of the genomic RNAs.
Highly Sensitive Detection of Zika Virus Nonstructural Protein 1 in Serum Samples by a Two-Site Nanobody ELISA.
HIV seroconversion during pregnancy and risk for mother-to-infant transmission.
Hsp90 Inhibitors Exhibit Resistance-Free Antiviral Activity against Respiratory Syncytial Virus.
Human Enterovirus Group B Viruses Rely on Vimentin Dynamics for Efficient Processing of Viral Nonstructural Proteins.
Human immunodeficiency virus type 1 RNA polymerase chain reaction reasonably excludes infection in exposed infants.
Human parvovirus B19 infection causes cell cycle arrest of human erythroid progenitors at late S phase that favors viral DNA replication.
Identification and characterization of a double-stranded RNA- reovirus temperature-sensitive mutant defective in minor core protein mu2.
Identification and characterization of the alc gene product of bacteriophage T4.
Identification of a new HIV type 1 circulating BF intersubtype recombinant form (CRF47_BF) in Spain.
Identification of an export control sequence and a requirement for the KH domains in ICP27 from herpes simplex virus type 1.
Identification of beta-subunit of bacterial RNA-polymerase--a non-species-specific bacterial protein--as target of antibodies in primary biliary cirrhosis.
Identification of GII.14[P7] norovirus and its genomic mutations from a case of long-term infection in a post-symptomatic individual.
Identification of hepatoprotective flavonolignans from silymarin.
Identification of novel inhibitors of HCV RNA-dependent RNA polymerase by pharmacophore-based virtual screening and in vitro evaluation.
Identification of Positively Charged Residues in Enterovirus 71 Capsid Protein VP1 Essential for Production of Infectious Particles.
Identification of potential inhibitors for HCV NS5b of genotype 4a by combining dynamic simulation, protein-ligand interaction fingerprint, 3D pharmacophore, docking and 3D QSAR.
Identification of protein interactions of grapevine fanleaf virus RNA-dependent RNA polymerase during infection of Nicotiana benthamiana by affinity purification and tandem mass spectrometry.
Identification of specific antigenic epitope at N-terminal segment of enterovirus 71 (EV-71) VP1 protein and characterization of its use in recombinant form for early diagnosis of EV-71 infection.
Identification of the cleavage site and determinants required for poliovirus 3CPro-catalyzed cleavage of human TATA-binding transcription factor TBP.
Identification of two forms of Q{beta} replicase with different thermal stabilities but identical RNA replication activity.
Identifying the RNA polymerases that synthesize specific transcripts of the Autographa californica nuclear polyhedrosis virus.
Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus vaccination.
Immunofluorescence-based biosensor for the determination of dengue virus NS1 in clinical samples.
Immunohistochemical and Taqman real-time PCR detection of mycobacterial infections in fish.
Importance of primer selection for the detection of hepatitis C virus RNA with the polymerase chain reaction assay.
Improved immunodetection of Taura syndrome virus using a monoclonal antibody specific for heterologously expressed VP1 capsid protein.
Improved serodiagnosis of hepatitis C virus infection with synthetic peptide antigen from capsid protein.
Improving dengue viral antigens detection in dengue patient serum specimens using a low pH glycine buffer treatment.
In Rhizobium leguminosarum, NodD represses its own transcription by competing with RNA polymerase for binding sites.
In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins.
In vitro inhibition of enterovirus 71 infection with a nickel ion/chitosan microcomposite.
In vitro product of an RNA polymerase induced in broadbean by infection with broadbean mottle virus.
In vitro synthesis of late bacteriophage phi 29 RNA.
In vitro transcription of pe38/polyhedrin hybrid promoters reveals sequences essential for recognition by the baculovirus-induced RNA polymerase and for the strength of very late viral promoters.
Increased transmission of vertical hepatitis C virus (HCV) infection to human immunodeficiency virus (HIV)-infected infants of HIV- and HCV-coinfected women.
Induction of RNA polymerase II activity in Junin virus-infected cells.
Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signalling.
Influenza A(H5N2) virus antibodies in humans after contact with infected poultry, Taiwan, 2012.
Influenza Virus Exploits an Interferon-Independent lncRNA to Preserve Viral RNA Synthesis through Stabilizing Viral RNA Polymerase PB1.
Infrequent development of resistance in genotype 1-6 hepatitis C virus-infected subjects treated with sofosbuvir in phase 2 and 3 clinical trials.
Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs.
Inhibition of host cell transcription by poliovirus: cleavage of transcription factor CREB by poliovirus-encoded protease 3Cpro.
Inhibition of influenza A virus replication by rifampicin and selenocystamine.
Inhibition of transcription of cytosine-containing DNA in vitro by the alc gene product of bacteriophage T4.
Inhibitors of the HCV NS5B polymerase: new hope for the treatment of hepatitis C infections.
Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and Resistance.
Initial binding of the broad spectrum antiviral nucleoside ribavirin to the hepatitis C virus RNA polymerase.
Initial results of efficacy and safety of Sofosbuvir among Pakistani Population: A real life trial - Hepatitis Eradication Accuracy Trial of Sofosbuvir (HEATS).
Initiation of transcription at phage T4 late promoters with purified RNA polymerase.
Initiation of transcription by bacteriophage T4-modified RNA polymerase independently of host sigma factor.
Integration of satellite bacteriophage P4 in Escherichia coli. DNA sequences of the phage and host regions involved in site-specific recombination.
Interferon-based combination treatment for chronic hepatitis C in the era of direct acting antivirals.
Interplay between co-divergence and cross-species transmission in the evolutionary history of bat coronaviruses.
Isolation of an RNA-directed RNA polymerase-specific cDNA clone from tomato.
Kinetic measurements of Escherichia coli RNA polymerase association with bacteriophage T7 early promoters.
Kinetic study of alterations in the host RNA polymerase and protein synthesis during phage Xp 10 infection.
KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182.
Kunjin RNA replication and applications of Kunjin replicons.
Lactoferrin inhibits enterovirus 71 infection by binding to VP1 protein and host cells.
Lassa Virus but Not Highly Pathogenic New World Arenaviruses Restrict Immunostimulatory dsRNA Accumulation During Infection.
Leader protein of foot-and-mouth disease virus is required for cleavage of the p220 component of the cap-binding protein complex.
Learning from our foes: a novel vaccine concept for influenza virus.
Ledipasvir/sofosbuvir fixed-dose combination for treatment of hepatitis C virus genotype 4 infection.
Limited overlap between phylogenetic HIV and hepatitis C virus clusters illustrates the dynamic sexual network structure of Dutch HIV-infected MSM.
Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein.
Localization of the Escherichia coli RNA polymerase beta' subunit residue phosphorylated by bacteriophage T7 kinase Gp0.7.
Locus-specific gene expression pattern suggests a unique propagation strategy for a giant algal virus.
Longitudinal analysis of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte responses: a predominant gag-specific response is associated with nonprogressive infection.
Loss of sigma-factor of RNA polymerase of Xanthomonas campestris pv. oryzae during phage Xp10 infection.
Lycorine, a non-nucleoside RNA dependent RNA polymerase inhibitor, as potential treatment for emerging coronavirus infections.
Lytic Infection with Murine Gammaherpesvirus 68 Activates Host and Viral RNA Polymerase III Promoters and Enhances Noncoding RNA Expression.
Management of post liver transplantation recurrent hepatitis C infection with directly acting antiviral drugs: a review.
Manipulated bio antimicrobial peptides from probiotic bacteria as proposed drugs for COVID-19 disease.
Mapping of Transcription Termination within the S Segment of SFTS Phlebovirus Facilitated Generation of NSs Deletant Viruses.
Mass spectrometric analysis of host cell proteins interacting with dengue virus nonstructural protein 1 in dengue virus-infected HepG2 cells.
Maternal and Neonatal Outcomes during Dengue Infection Outbreak at a Tertiary National Hospital in Endemic Area of Indonesia.
Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
Mitotic stability of infection-induced resistance to plum pox potyvirus associated with transgene silencing and DNA methylation.
Mixed HCV Infection of Genotype 1B and Other Genotypes Influences Non-response during Daclatasvir + Asunaprevir Combination Therapy.
Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates.
Modification of RNA polymerase after T3 phage infection of Escherichia coli B.
Modification of RNA polymerase IIO subspecies after poliovirus infection.
Modulation of vaccine-induced immune responses to hepatitis C virus in rhesus macaques by altering priming before adenovirus boosting.
Modulatory effects of the human heat shock protein 70 on DNA vaccination.
Molecular characterization of the small nonstructural proteins of parvovirus Aleutian mink disease virus (AMDV) during infection.
Molecular cloning and characterization of grouper Kr?ppel-like factor 9 gene: Involvement in the fish immune response to viral infection.
Molecular cloning of Kuruma shrimp Marsupenaeus japonicus endonuclease-reverse transcriptase and its positive role in white spot syndrome virus and Vibrio alginolyticus infection.
Molecular detection of murine norovirus from experimentally and spontaneously infected mice.
Molecular docking and dynamics studies of Nicotinamide Riboside as a potential multi-target nutraceutical against SARS-CoV-2 entry, replication, and transcription: A new insight.
Molecular dynamics analysis of N-acetyl-D-glucosamine against specific SARS-CoV-2's pathogenicity factors.
Molecular epidemiology of an enterovirus A71 outbreak associated with severe neurological disease, Spain, 2016.
Molecular genetic and structural modeling studies of Staphylococcus aureus RNA polymerase and the fitness of rifampin resistance genotypes in relation to clinical prevalence.
Molecular pathways: rodent parvoviruses--mechanisms of oncolysis and prospects for clinical cancer treatment.
Mouse norovirus replication is associated with virus-induced vesicle clusters originating from membranes derived from the secretory pathway.
mRNA expression of proinflammatory cytokines in mouse CNS correlates with replication rate of semliki forest virus but not with the strain of viral proteins.
Multiple isoelectric forms of poliovirus RNA-dependent RNA polymerase: evidence for phosphorylation.
Multivalent binding of the partially disordered SARS-CoV-2 nucleocapsid phosphoprotein dimer to RNA.
Mutations in nonstructural protein 5A gene and response to interferon in hepatitis C virus genotype 2 infection.
Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection.
Mutations in the nonstructural protein 5A gene and response to interferon therapy in young patients with chronic hepatitis C virus 1b infection.
Natural infection of free-ranging mandrills (Mandrillus sphinx) by enteroviruses and astroviruses in southern Gabon.
New antiviral agents for hepatitis C.
New Non-Nucleocide NS5B Protein Inhibitors for the Treatment of Chronic Hepatitis C Infection.
No Clinically Relevant Drug-Drug Interactions between Methadone or Buprenorphine-Naloxone and Antiviral Combination Glecaprevir and Pibrentasvir.
No viral gene is able to elicit RNA-dependent RNA polymerase in cucumber mosaic virus-infected cucumber cotyledons.
Non-nucleoside inhibitors of the HCV NS5B polymerase: progress in the discovery and development of novel agents for the treatment of HCV infections.
Nonstructural protein 1-specific immunoglobulin m and g antibody capture enzyme-linked immunosorbent assays in diagnosis of flaviviral infections in humans.
Nonstructural protein 11 (nsp11) of porcine reproductive and respiratory syndrome virus (PRRSV) promotes PRRSV infection in MARC-145 cells.
Nonstructural protein NS26 of grass carp reovirus is a principal regulator for viral replication and infection.
Nonstructural protein Pns12 of rice dwarf virus is a principal regulator for viral replication and infection in its insect vector.
Norovirus infection results in eIF2? independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation.
Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin ?/?1 Heterodimer.
Novel functions of the alphavirus nonstructural protein nsP3 C-terminal region.
NS1 glycoprotein detection in serum and urine as an electrochemical screening immunosensor for dengue and Zika virus.
NS5 Conservative Site Is Required for Zika Virus to Restrict the RIG-I Signaling.
NS5B polymerase inhibitors in phase II clinical trials for HCV infection.
Nuclear exportin 1 facilitates turnip mosaic virus infection by exporting the sumoylated viral replicase and by repressing plant immunity.
Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin.
Nucleocytoplasmic shuttling of the West Nile virus RNA-dependent RNA polymerase NS5 is critical to infection.
Nucleotide sequence and transcription of a bacteriophage 29 early promoter.
Number and position of mutations in the interferon (IFN) sensitivity-determining region of the gene for nonstructural protein 5A correlate with IFN efficacy in hepatitis C virus genotype 1b infection.
Ombitasvir/Paritaprevir/Ritonavir Plus Dasabuvir: A Review in Chronic HCV Genotype 1 Infection.
On the chemical nature of alteration and modification of DNA dependent RNA polymerase of E. coli after T4 infection.
On the effect of bacteriophage infection on host RNA polymerase.
Open-label phase 2 study of faldaprevir, deleobuvir and ribavirin in Japanese treatment-naive patients with chronic hepatitis C virus genotype 1 infection.
Optimizing T-705 (favipiravir) treatment of severe influenza B virus infection in the immunocompromised mouse model.
Oral immunization of mice using Bifidobacterium longum expressing VP1 protein from enterovirus 71.
Organization and expression of the poxvirus genome.
OsRDR6 plays role in host defense against double-stranded RNA virus, Rice Dwarf Phytoreovirus.
Overexpression of microRNA gga-miR-21 in chicken fibroblasts suppresses replication of infectious bursal disease virus through inhibiting VP1 translation.
Parameters of RNA-dependent RNA polymerase activity in a mengovirus-infected Ehrlich ascites carcinoma cell-free system.
Permissive replication of homologous murine rotavirus in the mouse intestine is primarily regulated by VP4 and NSP1.
Persistence of antibodies to West Nile virus nonstructural protein 5.
Phage T4 infection restricts rRNA synthesis by E. coli RNA polymerase.
Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of the Hepatitis C Virus NS5B Polymerase Inhibitor Sofosbuvir.
Pharmacokinetics of hepatitis C virus NS5A inhibitor JNJ-56914845 (GSK2336805) in subjects with hepatic impairment.
Phenotypic characterization of temperature-sensitive mutants of vaccinia virus with mutations in a 135,000-Mr subunit of the virion-associated DNA-dependent RNA polymerase.
Phenyl substituted 3-hydroxypyridin-2(1H)-ones: Inhibitors of influenza A endonuclease.
Phenyl substituted 4-hydroxypyridazin-3(2H)-ones and 5-hydroxypyrimidin-4(3H)-ones: inhibitors of influenza A endonuclease.
Phosphorylation of the beta' Subunit of RNA Polymerase and Other Host Proteins upon phiCd1 Infection of Caulobacter crescentus.
Phosphorylation of the viral nonstructural protein NS1 during MVMp infection of A9 cells.
Physical and functional domains of the herpes simplex virus transcriptional regulatory protein ICP4.
Plant-Produced Anti-Enterovirus 71 (EV71) Monoclonal Antibody Efficiently Protects Mice Against EV71 Infection.
Poliovirus-induced modification of host cell RNA polymerase IIO is prevented by cycloheximide and zinc.
Porcine deltacoronavirus nucleocapsid protein antagonizes IFN-? production by impairing dsRNA and PACT binding to RIG-I.
Porcine Reproductive and Respiratory Syndrome Virus Infection Induces both eIF2? Phosphorylation-Dependent and -Independent Host Translation Shutoff.
Porcine reproductive and respiratory syndrome virus nsp1? and nsp11 antagonize the antiviral activity of cholesterol-25-hydroxylase via lysosomal degradation.
Porcine transmissible gastroenteritis virus nonstructural protein 2 contributes to inflammation via NF-?B activation.
Potential Phosphorylation of Viral Nonstructural Protein 1 in Dengue Virus Infection.
Preclinical and Clinical Resistance Profile of EDP-239, a Novel HCV NS5A Inhibitor.
Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor.
Prevalence and characteristics of naturally occurring sofosbuvir resistance-associated variants in patients with hepatitis C virus genotype 1b infection.
Prevalence and genetic characterization of human coronaviruses in southern Thailand from July 2009 to January 2011.
Prevalence and molecular epidemiology of human coronavirus HKU1 in patients with acute respiratory illness.
Prevalence of antibodies to human parvovirus B19 nonstructural protein in persons with various clinical outcomes following B19 infection.
Prevalence of GB virus type C/hepatitis G virus RNA and of anti-E2 in individuals at high or low risk for blood-borne or sexually transmitted viruses: evidence of sexual and parenteral transmission.
Proceedings: Modification of E. coli RNA polymerase induced by T4 phage infection.
Production and characterisation of a viral RNA-dependent RNA polymerase induced in Escherichia coli Q. 13 by infection with bacteriophage Q .
Production and characterization of monospecific and bispecific antibodies against dengue virus NS1 protein.
Program of bacteriophage gh-1 DNA transcription in infected Pseudomonas putida.
Progress and development of small molecule HCV antivirals.
Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus.
Protective immune response in mice vaccinated with a recombinant adenovirus containing capsid precursor polypeptide P1, nonstructural protein 2A and 3C protease genes (P12A3C) of encephalomyocarditis virus.
Purification and identification of the RNA-dependent RNA polymerase of foot-and-mouth disease virus.
Purification and properties of RNA polymerase of phage KB1.
Q63, a novel DENV2 RdRp non-nucleoside inhibitor, inhibited DENV2 replication and infection.
Randomized, placebo-controlled, single-ascending-dose study of BMS-791325, a hepatitis C virus (HCV) NS5B polymerase inhibitor, in HCV genotype 1 infection.
Re-evaluation of the pathogenic roles of nonstructural protein 1 and its antibodies during dengue virus infection.
Rearrangements of rotavirus genomic segment 11 are generated during acute infection of immunocompetent children and do not occur at random.
Recent advances in drug discovery of benzothiadiazine and related analogs as HCV NS5B polymerase inhibitors.
Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection.
Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation.
Recombinant fusion protein and DNA vaccines against foot and mouth disease virus infection in guinea pig and swine.
Recombinant Rotaviruses Rescued by Reverse Genetics Reveal the Role of NSP5 Hyperphosphorylation in the Assembly of Viral Factories.
Recombinant VP1 protein as a potential marker for the diagnosis of acute hepatitis A virus infection.
Recovery of NV knockout infectious hematopoietic necrosis virus expressing foreign genes.
Reduced Featured k-NN Classifier Model Optimal for Classification of Dengue Fever from Salivary Raman Spectra.
Reduction of the risk of transfusion-transmitted human immunodeficiency virus (HIV) infection by using an HIV antigen/antibody combination assay in blood donation screening in Cameroon.
Regulation of Chlamydia Gene Expression by Tandem Promoters with Different Temporal Patterns.
Regulation of promoter selection by the bacteriophage T7 RNA polymerase in vitro.
Regulation of single-strand RNA synthesis of alfalfa mosaic virus in non-transgenic cowpea protoplasts by the viral coat protein.
Regulation of the temporal synthesis of proteins in bacteriophage BF23-infected cells.
Regulation of transcription of the Xp10 genome in bacteriophage-infected Xanthomonas campestris pv. oryzae.
Relationship between nonstructural protein 1 detection and plasma virus load in Dengue patients.
Relationship between RNA polymerase II and efficiency of vaccinia virus replication.
Release of RNA polymerase from vero cell mitochondria after herpes simplex virus type 1 infection.
Repeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of foot-and-mouth disease virus in host cells.
Replication-competent influenza A virus that encodes a split-green fluorescent protein-tagged PB2 polymerase subunit allows live-cell imaging of the virus life cycle.
Resistance analysis and characterization of NITD008 as an adenosine analog inhibitor against hepatitis C virus.
Respiratory Syncytial Virus NS1 Protein Colocalizes with Mitochondrial Antiviral Signaling Protein MAVS following Infection.
Restriction enzyme accessibility and RNA polymerase localization on transcriptionally active SV40 minichromosomes isolated late in infection.
Rhinovirus 16 2A Protease Affects Nuclear Localization of 3CD during Infection.
Ribavirin for Hepatitis E Virus Infection After Organ Transplantation: A Large European Retrospective Multicenter Study.
Ribavirin resistance in hepatitis C virus replicon-containing cell lines conferred by changes in the cell line or mutations in the replicon RNA.
Rifampicin-resistant bacteriophage PBS2 infection and RNA polymerase in Bacillus subtilis.
Rifampin-resistance-associated mutations in the rifampin-resistance-determining region of the rpoB gene of Mycobacterium tuberculosis clinical isolates in Shanghai, PR China.
RNA elements required for RNA recombination function as replication enhancers in vitro and in vivo in a plus-strand RNA virus.
RNA ligands activate the Machupo virus polymerase and guide promoter usage.
RNA polymerase activity and protein synthesis in brome mosaic virus-infected protoplasts.
RNA polymerase activity following infection with murine leukemia virus.
RNA polymerase and the shut-off of host RNA and protein synthesis in T4 phage infection.
RNA polymerase from phage SP01-infected and uninfected Bacillus subtilis.
RNA polymerase-associated transcription specificity factor encoded by vaccinia virus.
RNA recombination in Hepatitis delta virus: Identification of a novel naturally occurring recombinant.
RNA-binding properties of a translational activator, the adenovirus L4 100-kilodalton protein.
RNA-binding protein CPEB1 remodels host and viral RNA landscapes.
RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic.
RNA-dependent RNA polymerase 1 delays the accumulation of viroids in infected plants.
RNA-dependent RNA polymerase 6 of rice (Oryza sativa) plays role in host defense against negative-strand RNA virus, Rice stripe virus.
RNA-dependent RNA polymerase, RdRP, a promising therapeutic target for cancer and potentially COVID-19.
RNA-Free and Ribonucleoprotein-Associated Influenza Virus Polymerases Directly Bind the Serine-5-Phosphorylated Carboxyl-Terminal Domain of Host RNA Polymerase II.
RNAi-based inhibition of infectious myonecrosis virus replication in Pacific white shrimp Litopenaeus vannamei.
Role for the paramyxovirus genomic promoter in limiting host cell antiviral responses and cell killing.
Role of Enteroviral RNA-Dependent RNA Polymerase in Regulation of MDA5-Mediated Beta Interferon Activation.
Role of intrafamilial transmission in high prevalence of hepatitis C virus in Egypt.
Role of Noncoding RNAs in the Regulation of P-TEFb Availability and Enzymatic Activity.
Roles of polyamines in the replication of animal viruses.
Roles of viroplasm-like structures formed by nonstructural protein NSs in infection with severe fever with thrombocytopenia syndrome virus.
Rotavirus nonstructural protein NSP4 induces heterotypic antibody responses during natural infection in children.
Safety and Efficacy of Elbasvir/Grazoprevir in Patients With Hepatitis C Virus Infection and Compensated Cirrhosis: An Integrated Analysis.
Safety, tolerability, and pharmacokinetics of AL-335 in healthy volunteers and hepatitis C virus-infected subjects.
Salicylic acid-mediated and RNA-silencing defense mechanisms cooperate in the restriction of systemic spread of plum pox virus in tobacco.
SARS-CoV-2 NSP12 Protein Is Not an Interferon-? Antagonist.
Schlafen 11 Restricts Flavivirus Replication.
Screening for Antiviral Medaka Haploid Embryonic Stem Cells by Genome Wide Mutagenesis.
Sequence analysis of group B rotavirus gene 1 and definition of a rotavirus-specific sequence motif within the RNA polymerase gene.
Seraprevir and sofosbuvir for treatment of chronic hepatitis C virus infection: A single-arm, open-label, phase 3 trial.
Serial real-time RT-PCR and serology measurements substantially improve Zika and Dengue virus infection classification in a co-circulation area.
Seroepidemiology of human bocavirus in Hokkaido prefecture, Japan.
Serologic Prevalence of MPV1 in Mouse Strains in a Commercial Laboratory Mouse Colony Determined by Using VP1 Antigen.
Serotype-Specific Anti-Dengue Virus NS1 Mouse Antibodies Cross-React with prM and Are Potentially Involved in Virus Production.
Serum concentration and increased temperature alter Mayaro virus RNA and protein synthesis in Aedes albopictus (mosquito)-infected cells.
Serum hepatitis C virus RNA levels in chronic hepatitis C--importance for outcome of interferon alfa-2b treatment.
Significance of NS5B Substitutions in Genotype 1b Hepatitis C Virus Evaluated by Bioinformatics Analysis.
Silencing the tobacco gene for RNA-dependent RNA polymerase 1 and infection by potato virus Y cause remodeling of cellular organelles.
Simultaneous detection of both hepatitis B virus DNA and hepatitis C virus RNA using a combined one-step polymerase chain reaction technique.
Sindbis virus RNA polymerase is degraded by the N-end rule pathway.
Single amino acid substitutions in the coat protein and RNA-dependent RNA polymerase alleviated the virulence of Cucumber green mottle mosaic virus and conferred cross protection against severe infection.
Site of synthesis of membrane and nonmembrane proteins of vesicular stomatitis virus.
SIVMAC Vpx improves the transduction of dendritic cells with nonintegrative HIV-1-derived vectors.
Sofosbuvir in the treatment of chronic hepatitis C: new dog, new tricks.
Sofosbuvir plus ribavirin in Japanese patients with chronic genotype 2 HCV infection: an open-label, phase 3 trial.
Sofosbuvir/velpatasvir fixed-dose combination for the treatment of chronic hepatitis C virus infection.
Sofosbuvir/Velpatasvir: A Review in Chronic Hepatitis C.
Stable polypeptides associated with the 250S mengovirus-induced RNA polymerase structure.
Stereoselective Synthesis and Biological Evaluations of Novel 3'-Deoxy-4'-azaribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication.
Structural comparison of the Autographa californica nuclear polyhedrosis virus-induced RNA polymerase and the three nuclear RNA polymerases from the host, Spodoptera frugiperda.
Structure and replication of hepatitis delta virus RNA.
Structure of the enterovirus D68 RNA-dependent RNA polymerase in complex with NADPH implicates an inhibitor binding site in the RNA template tunnel.
Structure of the Qbeta replicase, an RNA-dependent RNA polymerase consisting of viral and host proteins.
Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP.
Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase.
Subcellular proteomic analysis of human host cells infected with H3N2 swine influenza virus.
Substantial portions of the 5' and intercistronic noncoding regions of cowpea chlorotic mottle virus RNA3 are dispensable for systemic infection but influence viral competitiveness and infection pathology.
Substrate selectivity of Dengue and Zika virus NS5 polymerase towards 2'-modified nucleotide analogues.
SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D to Facilitate Viral Replication.
SUMO1 Modification Facilitates Avibirnavirus Replication by Stabilizing Polymerase VP1.
Suppression of murine cytomegalovirus (MCMV) replication with a DNA vaccine encoding MCMV M84 (a homolog of human cytomegalovirus pp65).
Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability.
Synthesis, posttranslational modifications, and nuclear transport of polyomavirus major capsid protein VP1.
Systemic antiviral silencing in plants.
Systemic Expression of a Viral RdRP Protects Against Retrovirus Infection and Disease.
T Cell Responses to Nonstructural Protein 3 Distinguish Infections by Dengue and Zika Viruses.
T7 phage protein Gp2 inhibits the Escherichia coli RNA polymerase by antagonizing stable DNA strand separation near the transcription start site.
TDP-43 proteinopathy in Theiler's murine encephalomyelitis virus infection.
Temperature-sensitive mutants of vesicular stomatitis virus: viral RNA synthesis in cells infected with mutants belonging to complementation group I.
Template requirements for recognition and copying by Sindbis virus RNA-dependent RNA polymerase.
Template-dependent RNA polymerase from black beetle virus-infected Drosophila melanogaster cells.
Temporal studies of factors associated with changes in transcription during Q fever.
Termination of transcription of the coliphage T7 "early" operon in vitro: slowness of enzyme release, and lack of any role for sigma.
The 2b protein and C-terminal region of the 2a protein indispensably facilitate systemic movement of cucumber mosaic virus in radish with supplementary function by either the 3a or the coat protein.
The 2b protein of cucumoviruses has a role in promoting the cell-to-cell movement of pseudorecombinant viruses.
The ?CPG1 chlamydiaphage can infect Chlamydia trachomatis and significantly reduce its infectivity.
The ABL-MYC retrovirus generates antigen-specific plasmacytomas by in vitro infection of activated B lymphocytes from spleen and other murine lymphoid organs.
The active form of the norovirus RNA-dependent RNA polymerase is a homodimer with cooperative activity.
The Arabidopsis AtNPR1 inversely modulates defense responses against fungal, bacterial, or viral pathogens while conferring hypersensitivity to abiotic stresses in transgenic rice.
The barley stripe mosaic virus 58-kilodalton beta(b) protein is a multifunctional RNA binding protein.
The CaMV transactivator/viroplasmin interferes with RDR6-dependent trans-acting and secondary siRNA pathways in Arabidopsis.
The changing face of Hepatitis C: Recent Advances on HCV Inhibitors Targeting NS5A.
The Dengue Virus Nonstructural Protein 1 (NS1) Is Secreted from Mosquito Cells in Association with the Intracellular Cholesterol Transporter Chaperone Caveolin Complex.
The effect of a bacteriophage T4-induced polypeptide on host RNA polymerase interaction with promoters.
The effects of herpes simplex virus type 1 on cellular DNA-dependent RNA polymerase activities.
The Escherichia coli RNA polymerase.anti-sigma 70 AsiA complex utilizes alpha-carboxyl-terminal domain upstream promoter contacts to transcribe from a -10/-35 promoter.
The expression of IFN-? is suppressed by the viral 3D polymerase via its impact on PGAM5 expression during enterovirus D68 infection.
The Good, the Bad, and the Shocking: The Multiple Roles of Dengue Virus Nonstructural Protein 1 in Protection and Pathogenesis.
The hepatitis C revolution part 2: difficult-to-treat groups and experimental approaches.
The humoral response to heat shock protein 70 in human and murine Schistosomiasis mansoni.
The influence of RNA-dependent RNA polymerase 1 on potato virus Y infection and on other antiviral response genes.
The late expression factors 8 and 9 and possibly the phosphoprotein p78/83 of Autographa californica multicapsid nucleopolyhedrovirus are components of the virus-induced RNA polymerase.
The Mechanism and Clinical Outcome of patients with Corona Virus Disease 2019 Whose Nucleic Acid Test has changed from negative to positive, and the therapeutic efficacy of Favipiravir: A structured summary of a study protocol for a randomised controlled trial.
The NS5 protein of the virulent West Nile virus NY99 strain is a potent antagonist of type I interferon-mediated JAK-STAT signaling.
The Nucleocapsid Protein and Nonstructural Protein 10 of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Enhance CD83 Production via NF-?B and Sp1 Signaling Pathways.
The oncogenic role of NS5A of hepatitis C virus is mediated by up-regulation of survivin gene expression in the Hepatocellular cell through p53 and NF-?B pathways.
The optimal temperature for RNA replication in cells infected by Soil-borne wheat mosaic virus is 17 degrees C.
The ORF, regulated synthesis, and persistence-specific variation of influenza C viral NS1 protein.
The overexpression of the trypanosomatid-exclusive TcRBP19 RNA-binding protein affects cellular infection by Trypanosoma cruzi.
The pathogenesis of infection with minute virus of mice depends on expression of the small nonstructural protein NS2 and on the genotype of the allotropic determinants VP1 and VP2.
The phage T4 MotA transcription factor contains a novel DNA binding motif that specifically recognizes modified DNA.
The Phage-Encoded N-Acetyltransferase Rac Mediates Inactivation of Pseudomonas aeruginosa Transcription by Cleavage of the RNA Polymerase Alpha Subunit.
The plant defense response to cucumber mosaic virus in cowpea is elicited by the viral polymerase gene and affects virus accumulation in single cells.
The presence of resistance mutations to protease and polymerase inhibitors in Hepatitis C virus sequences from the Los Alamos databank.
The regulation of transcription in bacteriophage T5-infected Escherichia coli.
The RNA polymerase of influenza a virus is stabilized by interaction with its viral RNA promoter.
The RNA-dependent RNA polymerase of cowpea is not involved in cowpea mosaic virus RNA replication: immunological evidence.
The strategy of infection as a criterion for phylogenetic relationships of non-coli phages morphologically similar to phage T7.
The switch between acute and persistent paramyxovirus infection caused by single amino acid substitutions in the RNA polymerase P subunit.
The tail sheath of bacteriophage N4 interacts with the Escherichia coli receptor.
The tyrosine 73 and serine 83 dephosphorylation of H1N1 swine influenza virus NS1 protein attenuates virus replication and induces high levels of beta interferon.
The use of dengue nonstructural protein 1 antigen for the early diagnosis during the febrile stage in patients with dengue infection.
The variations of VP1 protein might be associated with nervous system symptoms caused by enterovirus 71 infection.
The viral mechanism of Reye's syndrome.
The VP1 protein of avian encephalomyelitis virus is a major host-protective immunogen that serves as diagnostic potential.
Therapeutic targeting of measles virus polymerase with ERDRP-0519 suppresses all RNA synthesis activity.
Thiolutin resistant mutants of Escherichia coli are they RNA chain initiation mutants?
Three-dimensional model for the isolated recombinant influenza virus polymerase heterotrimer.
Time to viral suppression is not related to achievement of SVR12 in HCV GT1-infected patients treated with ombitasvir/paritaprevir/ritonavir and dasabuvir with or without ribavirin.
Transcription from a bacteriophage T4 middle promoter using T4 motA protein and phage-modified RNA polymerase.
Transcription of adenoviral genetic information in isolated nuclei. Characterization of viral RNA sequences synthesized in vitro.
Transcription of bacteriophage T4 genome in vitro. Heterogeneity of RNA polymerase in crude extracts of normal and T4-infected Escherichia coli B.
Transcription of the bovine parvovirus genome in isolated nuclei.
Transcription Profiling of Bacillus subtilis Cells Infected with AR9, a Giant Phage Encoding Two Multisubunit RNA Polymerases.
Transcription-independent DNA translocation of bacteriophage T7 DNA into Escherichia coli.
Transcriptional regulation of three double-stranded RNA segments of bacteriophage phi 6 in vitro.
Transcriptional takeover by sigma appropriation: remodelling of the sigma70 subunit of Escherichia coli RNA polymerase by the bacteriophage T4 activator MotA and co-activator AsiA.
Transcriptional termination at the end of the early region of bacteriophages T3 and T7 is not affected by polarity suppressors.
Transcriptionally defective nucleocapsids of vesicular stomatitis virus from cells treated with indomethacin.
Transcriptome analysis of yellow passion fruit in response to cucumber mosaic virus infection.
Transducin ?-like 1 X-linked receptor 1 (TBLR1) affects RGNNV infection through negative regulation of interferon immune response in orange-spotted grouper, Epinephelus coioides.
Transient activation of RNA polymerase in Escherichia coli B after infection with bacteriophage T4.
Translation and processing of mouse hepatitis virus virion RNA in a cell-free system.
Transmission genetics of drug-resistant hepatitis C virus.
Treatment of hepatitis C virus in HIV patients: a review.
Tumefactive multiple sclerosis and hepatitis C virus 2a/2C infection: Dual benefit of long-term interferon beta-1a therapy?
Type I interferon antagonistic properties of influenza B virus polymerase proteins.
Ultrastructural visualization of hepatitis C virus components in human and primate liver biopsies.
Update on hepatitis C virus resistance to direct-acting antiviral agents.
Upregulation of CHOP participates in caspase activation and virus release in human astrovirus-infected cells.
Use and interpretation of HCV diagnostic tests in the clinical setting.
Use of dengue nonstructural protein 1 antigen for the early diagnosis of dengue infection.
Utility of a rapid immunochromatographic strip test in detecting canine parvovirus infection compared with polymerase chain reaction.
VAPC, an Human Endogenous Inhibitor for Hepatitis C Virus (HCV) Infection, Is Intrinsically Unstructured but Forms a "Fuzzy Complex" with HCV NS5B.
Variable Inhibition of Zika Virus Replication by Different Wolbachia Strains in Mosquito Cell Cultures.
Variations in the Viral NS5B Region in Japanese Patients with Chronic Hepatitis C Virus Genotype 1b Infection. No Specific Amino Acid Substitution Was Identified as Determinants of Treatment Response to Interferon/Ribavirin Combination Therapy.
Variations of hepatitis C virus NS5B sequence (nucleotides 8261-8566) do not correlate with response to interferon-alpha therapy.
Victorivirus, a new genus of fungal viruses in the family Totiviridae.
Viral replication. Structural basis for RNA replication by the hepatitis C virus polymerase.
Viral RNA synthesis and levels of DNA-dependent RNA polymerases during replication of adenovirus 2.
Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts.
Viral, host and environmental factors that favor anthropozoonotic spillover of coronaviruses: An opinionated review, focusing on SARS-CoV, MERS-CoV and SARS-CoV-2.
Virion-associated RNA polymerase required for bacteriophage N4 development.
Virological, serological, and clinical features of an outbreak of acute gastroenteritis due to recombinant genogroup II norovirus in an infant home.
Viruses within the Flaviviridae decrease CD4 expression and inhibit HIV replication in human CD4+ cells.
Visualizing the beta interferon response in mice during infection with influenza A viruses expressing or lacking nonstructural protein 1.
Vitamin D and lumisterol novel metabolites can inhibit SARS-CoV-2 replication machinery enzymes.
X-ray crystal structure of the polymerase domain of the bacteriophage N4 virion RNA polymerase.
[Cloning and infectivity analysis of the cDNAs of tobacco mosaic virus (tomato strain) and its attenuated virus(N14) genomes]
[Coupling of bacteriophage T7 DNA penetration with its transcription, during infection]
[Detection of human parvovirus B19 nonstructural protein DNA by nested- polymerase chain reaction in pregnant women]
[Drug clinics. How I treat HIV infections. II. Nucleoside reverse transcriptase inhibitors]
[Expression of recombinant VP1 protein of enterovirus 71 and development of serological assay for detection of EV71 infection]
[Marburg and Ebola hemorrhagic fevers--pathogens, epidemiology and therapy].
[Persistent Shallot virus X infection correlates with transcriptional repression of plant cell RNA-dependent RNA polymerase and DCL proteins in plant roots].
[Pharma-clinics. How I treat ... HIV infection. III. Non-nucleoside reverse transcriptase inhibitors]
[Structure, function and regulation of expression of influenza virus matrix M1 protein]
[Study on specificity of IgM antibody response in patients with coxsackie virus B infection]
[Transcription and replication of influenza virus genome]
Infertility
C. elegans SUP-46, an HNRNPM family RNA-binding protein that prevents paternally-mediated epigenetic sterility.
Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL.
Comparative testis proteome of cattleyak from different developmental stages.
Emaravirus-specific degenerate PCR primers allowed the identification of partial RNA-dependent RNA polymerase sequences of Maize red stripe virus and Pigeonpea sterility mosaic virus.
KEX2 mutations suppress RNA polymerase II mutants and alter the temperature range of yeast cell growth.
Requirement for ERI/DICER Complex in Endogenous RNAi and Sperm Development in Caenorhabditis elegans.
The RNA-binding specificity of the mouse Dazl protein.
Infertility, Female
Chromatin Modification and Global Transcriptional Silencing in the Oocyte Mediated by the mRNA Decay Activator ZFP36L2.
The Drosophila RNA-binding protein Lark is required for the organization of the actin cytoskeleton and Hu-li tai shao localization during oogenesis.
Infertility, Male
Ablation of the Sam68 gene impairs female fertility and gonadotropin-dependent follicle development.
Cold-inducible RNA-binding protein (CIRP) regulates target mRNA stabilization in the mouse testis.
Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter.
Motor coordination defects in mice deficient for the Sam68 RNA-binding protein.
[Long non-coding RNAs in plants].
Influenza in Birds
A Single Amino Acid in the M1 Protein Responsible for the Different Pathogenic Potentials of H5N1 Highly Pathogenic Avian Influenza Virus Strains.
Annexin A2 (ANXA2) interacts with nonstructural protein 1 and promotes the replication of highly pathogenic H5N1 avian influenza virus.
Avian Influenza A Virus Polymerase Recruits Cellular RNA Helicase eIF4A3 to Promote Viral mRNA Splicing and Spliced mRNA Nuclear Export.
Biochemical impact of the host adaptation associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex.
China makes an impressive breakthrough in avian influenza virus research - Discovering the "heart" of avian infl uenza virus.
Cloning and expression of highly pathogenic avian influenza virus full-length nonstructural gene in Pichia pastoris.
Comparative study of virion transcriptase of some influenza virus strains.
Computational identification of reassortments in avian influenza viruses.
Correlation between polymerase activity and pathogenicity in two duck H5N1 influenza viruses suggests that the polymerase contributes to pathogenicity.
Detection of antibodies to the nonstructural protein (NS1) of avian influenza viruses allows distinction between vaccinated and infected chickens.
Effect of adamantane derivatives on the activity of orthomyxovirus RNA-dependent RNA polymerase.
Expanding the frontiers of existing antiviral drugs: possible effects of HIV-1 protease inhibitors against SARS and avian influenza.
Expression profiles of interferon-related genes in cells infected with influenza A viruses or transiently transfected with plasmids encoding viral RNA polymerase.
Host ANP32A mediates the assembly of the influenza virus replicase.
Host restriction of influenza virus polymerase activity by PB2 627E is diminished on short viral templates in a nucleoprotein-independent manner.
Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air.
In vitro inhibition of negative strand virus transcriptase activity by proteins soluble in acidic chloroform-methanol.
Interaction of avian influenza virus NS1 protein and nucleolar and coiled-body phosphoprotein 1.
Interaction of M protein and RNP of fowl plague virus in vitro.
Interaction of Polymerase Subunit PB2 and NP with Importin alpha1 Is a Determinant of Host Range of Influenza A Virus.
Novel mutations in avian PA in combination with an adaptive mutation in PR8 NP exacerbate the virulence of PR8-derived recombinant influenza A viruses in mice.
Novel reassortant highly pathogenic H5N2 avian influenza viruses in poultry in China.
NP and NS1 proteins of H5N1 virus significantly upregulated IFITM1, IFITM2, and IFITM3 in A549 cells.
Pathogenicity and transmissibility of an H9N2 avian influenza virus that naturally harbors the mammalian-adaptive molecular factors in the hemagglutinin and PB2 proteins.
Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase.
Reassortments among Avian Influenza A(H5N1) Viruses Circulating in Indonesia, 2015-2016.
Screen Anti-influenza Lead Compounds That Target the PA(C) Subunit of H5N1 Viral RNA Polymerase.
Screening for lead compounds and herbal extracts with potential anti-influenza viral activity.
Structure and Function of the Influenza Virus Transcription and Replication Machinery.
The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon.
Virion transcriptase activity of rimantadine-sensitive and rimantadine-resistant variants of human influenza virus.
Virulence of H5N1 avian influenza virus enhanced by a 15-nucleotide deletion in the viral nonstructural gene.
[Preparation and characterization the polyclonal antibody of the nonstructural protein of human highly pathogenic H5N1 avian influenza viruses].
Influenza, Human
(19)F NMR reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza a virus.
1918 HA and the viral RNA polymerase complex enhance viral pathogenicity, but only HA induces aberrant host responses in mice.
A 48-amino-acid region of influenza A virus PB1 protein is sufficient for complex formation with PA.
A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits.
A cluster of conserved basic amino acids near the C-terminus of the PB1 subunit of the influenza virus RNA polymerase is involved in the regulation of viral transcription.
A Dual-Functioning 5'-PPP-NS1shRNA that Activates a RIG-I Antiviral Pathway and Suppresses Influenza NS1.
A frame shift mutation in a hot spot region of the nuclear autoantigen La (SS-B).
A Mechanism for Priming and Realignment during Influenza A Virus Replication.
A Mechanism for the Activation of the Influenza Virus Transcriptase.
A multi-functional enzyme with RNA polymerase and RNase activities: molecular anatomy of influenza virus RNA polymerase.
A Naturally Occurring Deletion in the Effector Domain of H5N1 Swine Influenza Virus Nonstructural Protein 1 Regulates Viral Fitness and Host Innate Immunity.
A new method for reconstituting influenza polymerase and RNA in vitro: a study of the promoter elements for cRNA and vRNA synthesis in vitro and viral rescue in vivo.
A new promoter-binding site in the PB1 subunit of the influenza A virus polymerase.
A non-PCR SPR platform using RNase H to detect MicroRNA 29a-3p from throat swabs of human subjects with influenza A virus H1N1 infection.
A novel antiviral agent which inhibits the endonuclease of influenza viruses.
A novel aqueous extract from rice fermented with Aspergillus oryzae and Saccharomyces cerevisiae possesses an anti-influenza A virus activity.
A novel function of the N-terminal domain of PA in assembly of influenza A virus RNA polymerase.
A novel functional site in the PB2 subunit of influenza A virus essential for acetyl-CoA interaction, RNA polymerase activity, and viral replication.
A novel mechanism of enhanced transcription activity and fidelity for influenza A viral RNA-dependent RNA polymerase.
A novel protein characterization based on Pseudo Amino Acids composition and Star-like graph topological indices.
A Novel Role for PDZ-Binding Motif of Influenza A Virus Nonstructural Protein 1 in Regulation of Host Susceptibility to Postinfluenza Bacterial Superinfections.
A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase.
A novel SUMOylation site in the influenza a virus NS1 protein identified with a highly sensitive FRET assay.
A novel type of influenza vaccine: safety and immunogenicity of replication-deficient influenza virus created by deletion of the interferon antagonist NS1.
A Nucleolar Protein, Ribosomal RNA Processing 1 Homolog B (RRP1B), Enhances the Recruitment of Cellular mRNA in Influenza Virus Transcription.
A Parallel Phenotypic Versus Target-Based Screening Strategy for RNA-Dependent RNA Polymerase Inhibitors of the Influenza A Virus.
A peptide derived from the C-terminus of PB1 inhibits influenza virus replication by interfering with viral polymerase assembly.
A prospective, randomized, open-label trial of early versus late favipiravir in hospitalized patients with COVID-19.
A quantitative strategy to detect changes in accessibility of protein regions to chemical modification on heterodimerization.
A rapid and highly sensitive method for diagnosis of equine influenza by antigen detection using immuno-PCR.
A recombinant influenza virus vaccine expressing the F protein of respiratory syncytial virus.
A sensitive, single-tube assay to measure the enzymatic activities of influenza RNA polymerase and other poly(A) polymerases: application to kinetic and inhibitor analysis.
A Single Amino Acid in the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses.
A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs.
A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase promotes the generation of defective interfering RNAs.
A single point mutation (Y89F) within the non-structural protein 1 of influenza A viruses limits epithelial cell tropism and virulence in mice.
A single-nucleotide natural variation (U4 to C4) in an influenza A virus promoter exhibits a large structural change: implications for differential viral RNA synthesis by RNA-dependent RNA polymerase.
Acetylation of the influenza A virus polymerase subunit PA in the N-terminal domain positively regulates its endonuclease activity.
Activation of influenza virus RNA polymerase by the 5' and 3' terminal duplex of genomic RNA.
Activation of influenza virus-associated RNA polymerase by cap-1 structure (m7GpppNm).
Activation of monocytes by three OspA vaccine candidates: lipoprotein OspA is a potent stimulator of monokines.
Activation of phosphatidylinositol 3-kinase signaling by the nonstructural NS1 protein is not conserved among type A and B influenza viruses.
Amino acid residues in the N-terminal region of the PA subunit of influenza A virus RNA polymerase play a critical role in protein stability, endonuclease activity, cap binding, and virion RNA promoter binding.
Amino acid substitutions affecting aspartic acid 605 and valine 606 decrease the interaction strength between the influenza virus RNA polymerase PB2 '627' domain and the viral nucleoprotein.
An A14U Substitution in the 3' Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs.
An in vivo study of the replication origin in the influenza virus complementary RNA.
An inhibitor of the particle-associated RNA-dependent RNA polymerase of influenza A and B viruses.
Analysis of oropouche virus L protein amino acid sequence showed the presence of an additional conserved region that could harbour an important role for the polymerase activity.
Analysis of the in vitro product of an RNA-dependent RNA polymerase isolated from influenza virus-infected cells.
Annotating Protein Functional Residues by Coupling High-Throughput Fitness Profile and Homologous-Structure Analysis.
Anthralin Suppresses the Proliferation of Influenza Virus by Inhibiting the Cap-Binding and Endonuclease Activity of Viral RNA Polymerase.
Anti-influenza activity of c60 fullerene derivatives.
Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts.
Anti-influenza activity of phenethylphenylphthalimide analogs derived from thalidomide.
Antibody-scanning and epitope-tagging methods; molecular mapping of proteins using antibodies.
Antigenic reactivity and electrophoretic migrational heterogeneity of the three polymerase proteins of type A human and animal influenza viruses.
Antigenic variation in the influenza A virus nonstructural protein, NS1.
Antisense oligonucleotides directed against the viral RNA polymerase gene enhance survival of mice infected with influenza A.
Antiviral activity of double-stranded RNA-binding protein PACT against influenza A virus mediated via suppression of viral RNA polymerase.
Antiviral activity of SA-2 against influenza A virus in vitro/vivo and its inhibition of RNA polymerase.
Antiviral effects of single-stranded polynucleotide inhibitors of the influenza virion-associated transcriptase against influenza virus infection of hamsters and ferrets.
Antiviral protective immunity induced by major histocompatibility complex class I molecule-restricted viral T-lymphocyte epitopes inserted in various positions in immunologically self and nonself proteins.
Antiviral response in pandemic influenza viruses.
Antiviral susceptibility of influenza viruses isolated from patients pre- and post-administration of favipiravir.
Apical transport of influenza A virus ribonucleoprotein requires Rab11-positive recycling endosome.
Application of a split luciferase complementation assay for the detection of viral protein-protein interactions.
Application of three duplex real-time PCR assays for simultaneous detection of human seasonal and avian influenza viruses.
Approved Antiviral Drugs over the Past 50 Years.
Artificial hybrids of influenza A virus RNA polymerase reveal PA subunit modulates its thermal sensitivity.
Assays to Measure the Activity of Influenza Virus Polymerase.
Association of the influenza A virus RNA-dependent RNA polymerase with cellular RNA polymerase II.
Association of the influenza virus RNA polymerase subunit PB2 with the host chaperonin CCT.
Avian Chaperonin Containing TCP1 Subunit 5 Supports Influenza A Virus Replication by Interacting With Viral Nucleoprotein, PB1, and PB2 Proteins.
AZT acts as an anti-influenza nucleotide triphosphate targeting the catalytic site of A/PR/8/34/H1N1 RNA dependent RNA polymerase.
Baloxavir Marboxil for Prophylaxis against Influenza in Household Contacts.
Baloxavir treatment delays influenza B virus transmission in ferrets and results in limited generation of drug-resistant variants.
Base-pair formation between noncapped influenza virus in vitro transcripts and 18S rRNA in rabbit reticulocyte 80S ribosome-mRNA complexes detected by psoralen photoreaction.
Base-pairing promotes leader selection to prime in vitro influenza genome transcription.
Basic amino acids in the N-terminal half of the PB2 subunit of influenza virus RNA polymerase are involved in both transcription and replication.
Binding mode prediction and inhibitor design of anti-influenza virus diketo acids targeting metalloenzyme RNA polymerase by molecular docking.
Biochemical and kinetic analysis of the influenza virus RNA polymerase purified from insect cells.
Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex.
Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors.
Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Polymerase activity and mechanisms of action of nucleotide analogs.
Biochemical studies on capped RNA primers identify a class of oligonucleotide inhibitors of the influenza virus RNA polymerase.
Biogenesis, assembly, and export of viral messenger ribonucleoproteins in the influenza A virus infected cell.
Biophysical characterization of sites of host adaptive mutation in the influenza A virus RNA polymerase PB2 RNA-binding domain.
Biophysical characterization of the complex between double-stranded RNA and the N-terminal domain of the NS1 protein from influenza A virus: evidence for a novel RNA-binding mode.
Broad influenza-specific CD8+ T-cell responses in humanized mice vaccinated with influenza virus vaccines.
Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap-dependent transcription.
Capped mRNAs may stimulate the influenza virion polymerase by allosteric modulation.
Cellular cap-binding proteins associate with influenza virus mRNAs.
Cellular DDX21 RNA Helicase Inhibits Influenza A Virus Replication but Is Counteracted by the Viral NS1 Protein.
Cellular human CLE/C14orf166 protein interacts with influenza virus polymerase and is required for viral replication.
Cellular protein HAX1 interacts with the influenza A virus PA polymerase subunit and impedes its nuclear translocation.
Characterization of a mitochondrial-targeting signal in the PB2 protein of influenza viruses.
Characterization of a temperature-sensitive mutant in the RNA polymerase PB2 subunit gene of influenza A/WSN/33 virus.
Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage.
Characterization of susceptibility variants of poliovirus grown in the presence of favipiravir.
Characterization of the interaction between the influenza A virus polymerase subunit PB1 and the host nuclear import factor Ran-binding protein 5.
Characterization of the RNA-fork model of virion RNA in the initiation of transcription in influenza A virus.
Cis-acting signals and trans-acting factors involved in influenza virus RNA synthesis.
Cloning DNA sequences from influenza viral RNA segments.
Co-incorporation of the PB2 and PA polymerase subunits from human H3N2 influenza virus is a critical determinant of the replication of reassortant ribonucleoprotein complexes.
Codon Deletions in the Influenza A Virus PA Gene Generate Temperature-Sensitive Viruses.
Codon usage characteristics of PB2 gene in influenza A H7N9 virus from different host species.
Combinations of favipiravir and peramivir for the treatment of pandemic influenza A/California/04/2009 (H1N1) virus infections in mice.
Comparative studies of wild-type and cold-mutant (temperature-sensitive) influenza viruses: independent segregation of temperature-sensitivity of virus replication from temperature-sensitivity of virion transcriptase activity during recombination of mutant A/Ann Arbor/6/60 with wild-type H3N2 strains.
Comparative study of virion transcriptase of some influenza virus strains.
Comparison of Influenza Virus Particle Purification Using Magnetic Sulfated Cellulose Particles with an Established Centrifugation Method for Analytics.
Comparison of the three large polymerase proteins of influenza A, B, and C viruses.
Comparison of two reconstituted systems for in vitro transcription and replication of influenza virus.
Comparison of vRNA and cRNA based reporters for detection of influenza replication.
Complex formation between influenza virus polymerase proteins expressed in Xenopus oocytes.
Comprehensive assessment of amino acid substitutions in the trimeric RNA polymerase complex of influenza A virus detected in clinical trials of baloxavir marboxil.
Comprehensive proteomic analysis of influenza virus polymerase complex reveals a novel association with mitochondrial proteins and RNA polymerase accessory factors.
Computational analysis of the effect of polymerase acidic (PA) gene mutation F35L in the 2009 pandemic influenza A (H1N1) virus on binding aspects of mononucleotides in the endonuclease domain.
Computational Studies of Selected Transition Metal Complexes as Potential Drug Candidates against the SARS-CoV-2 Virus.
Contribution of double-stranded RNA and CPSF30 binding domains of influenza virus NS1 to the inhibition of type I interferon production and activation of human dendritic cells.
Correlation between polymerase activity and pathogenicity in two duck H5N1 influenza viruses suggests that the polymerase contributes to pathogenicity.
Cryo-EM Structure of Influenza Virus RNA Polymerase Complex at 4.3 Å Resolution.
Cryptoporic acid E from Cryptoporus volvatus inhibits influenza virus replication in vitro.
Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site.
Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus.
Crystal structure of the RNA-dependent RNA polymerase from influenza C virus.
Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein.
Crystallization and preliminary X-ray diffraction studies of a surface mutant of the middle domain of PB2 from human influenza A (H1N1) virus.
Crystallization and X-ray diffraction analysis of the RNA primer/promoter-binding domain of influenza A virus RNA-dependent RNA polymerase PB2.
Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors.
Current and novel antiviral strategies for influenza infection.
Cyclin T1/CDK9 interacts with influenza A viral polymerase and facilitates its association with cellular RNA Polymerase II.
Deep sequencing reveals the eight facets of the influenza A/HongKong/1/1968 (H3N2) virus cap-snatching process.
Defective assembly of influenza A virus due to a mutation in the polymerase subunit PA.
Definition of the minimal viral components required for the initiation of unprimed RNA synthesis by influenza virus RNA polymerase.
Design and Construction of Aroyl-Hydrazone Derivatives: Synthesis, Crystal Structure, Molecular Docking and Their Biological Activities.
Detailed Molecular Interactions of Favipiravir with SARS-CoV-2, SARS-CoV, MERS-CoV, and Influenza Virus Polymerases In Silico.
Detection of antibodies to the nonstructural protein (NS1) of influenza A virus allows distinction between vaccinated and infected horses.
Detection of variants with reduced baloxavir marboxil susceptibility after treatment of children with influenza A during the 2018/2019 influenza season.
Development of a method for evaluating the mRNA transcription activity of influenza virus RNA-dependent RNA polymerase through real-time reverse transcription polymerase chain reaction.
Development of an HTS assay for the search of anti-influenza agents targeting the interaction of viral RNA with the NS1 protein.
Development of cycling probe based real-time PCR methodology for influenza A viruses possessing the PA/I38T amino acid substitution associated with reduced baloxavir susceptibility.
Diagnostic approach for differentiating infected from vaccinated poultry on the basis of antibodies to NS1, the nonstructural protein of influenza A virus.
Different de novo initiation strategies are used by influenza virus RNA polymerase on its cRNA and viral RNA promoters during viral RNA replication.
Differential effect of modified capped RNA substrates on influenza virus transcription.
Differential effects of NS1 proteins of human pandemic H1N1/2009, avian highly pathogenic H5N1, and low pathogenic H5N2 influenza A viruses on cellular pre-mRNA polyadenylation and mRNA translation.
Differential Modulation of Innate Immune Responses in Human Primary Cells by Influenza A Viruses Carrying Human or Avian Nonstructural Protein 1.
Differential role of the influenza A virus polymerase PA subunit for vRNA and cRNA promoter binding.
Differential roles of viral RNA and cRNA in functional modulation of the influenza virus RNA polymerase.
Differentiation of infected and vaccinated animals (DIVA) using the NS1 protein of avian influenza virus.
Dihydromyricetin is a new inhibitor of influenza polymerase PB2 subunit and influenza-induced inflammation.
Directly reconstructing principal components of heterogeneous particles from cryo-EM images.
Discovery of 5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazin-2(1H)-one derivatives as new potent PB2 inhibitors.
Discovery of anti-influenza nucleoside triphosphates targeting the catalytic site of A/PR/8/34/H1N1 polymerase.
Distinct regions of influenza virus PB1 polymerase subunit recognize vRNA and cRNA templates.
Distribution of lignin-carbohydrate complex in plant kingdom and its functionality as alternative medicine.
DnaJA1/Hsp40 is co-opted by influenza A virus to enhance its viral RNA polymerase activity.
Dual R108K and G189D Mutations in the NS1 Protein of A/H1N1 Influenza Virus Counteract Host Innate Immune Responses.
Effect of adamantane derivatives on the activity of orthomyxovirus RNA-dependent RNA polymerase.
Effect of high salt treatment on influenza B viral protein synthesis in MDCK cells.
Effect of ribavirin triphosphate on primer generation and elongation during influenza virus transcription in vitro.
Effects of polynucleotide inhibitors on transcriptional events of influenza virions.
Effects of selenazofurin and ribavirin and their 5'-triphosphates on replicative functions of influenza A and B viruses.
Effects on synaptic activity in cultured hippocampal neurons by influenza A viral proteins.
Efficient and regioselective one-step synthesis of 7-aryl-5-methyl- and 5-aryl-7-methyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivatives.
Efficient generation of influenza virus with a mouse RNA polymerase I-driven all-in-one plasmid.
Elucidation of basic mechanistic and kinetic properties of influenza endonuclease using chemically synthesized RNAs.
Encephalomyocarditis virus disrupts stress granules, the critical platform for triggering antiviral innate immune responses.
Enhanced expression of secretable influenza virus neuraminidase in suspension mammalian cells by influenza virus nonstructural protein 1.
Enhancement of Virus Replication in An Influenza A Virus NS1-Expresssing 293 Cell Line.
Enisamium is a small molecule inhibitor of the influenza A virus and SARS-CoV-2 RNA polymerases.
Enisamium Reduces Influenza Virus Shedding and Improves Patient Recovery by Inhibiting Viral RNA Polymerase Activity.
Entropy Hotspots for the Binding of Intrinsically Disordered Ligands to a Receptor Domain.
Epidemiology of influenza C virus in man: multiple evolutionary lineages and low rate of change.
Epitope mapping of the influenza A virus RNA polymerase PA using monoclonal antibodies
Epitope mapping of the influenza A virus RNA polymerase PA using monoclonal antibodies.
Equine-Like H3 Avian Influenza Viruses in Wild Birds, Chile.
Establishment of a Replicon Reporter of the Emerging Tick-Borne Bourbon Virus and Use It for Evaluation of Antivirals.
Establishment of canine RNA polymerase I-driven reverse genetics for influenza A virus: its application for H5N1 vaccine production.
Establishment of Vero cell RNA polymerase I-driven reverse genetics for influenza A virus and its application for pandemic (H1N1) 2009 influenza virus vaccine production.
Estimating the distribution of selection coefficients from phylogenetic data using sitewise mutation-selection models.
Ethanolic Extract of Melia Fructus Has Anti-influenza A Virus Activity by Affecting Viral Entry and Viral RNA Polymerase.
Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus.
Evidence for the involvement of influenza A (fowl plague Rostock) virus protein P2 in ApG and mRNA primed in vitro RNA synthesis.
Evidence that the C-terminal PB2-binding region of the influenza A virus PB1 protein is a discrete alpha-helical domain.
Evolution of influenza polymerase: nucleotide sequence of the PB2 gene of A/Chile/1/83 (H1 N1).
Evolutionary relatedness of the predicted gene product of RNA segment 2 of the tick-borne Dhori virus and the PB1 polymerase gene of influenza viruses.
Expanding the frontiers of existing antiviral drugs: possible effects of HIV-1 protease inhibitors against SARS and avian influenza.
Exploring the cycloheptathiophene-3-carboxamide scaffold to disrupt the interactions of the influenza polymerase subunits and obtain potent anti-influenza activity.
Exploring the molecular basis of dsRNA recognition by NS1 protein of influenza A virus using molecular dynamics simulation and free energy calculation.
Exploring the molecular mechanism of action between drug and RNA polymerase based on partially-resolved spatial structures.
Exploring Ugi-Azide Four-Component Reaction Products for Broad-Spectrum Influenza Antivirals with a High Genetic Barrier to Drug Resistance.
Expression of functional influenza virus RNA polymerase in the methylotrophic yeast Pichia pastoris.
Expression of H3N2 nucleoprotein in maize seeds and immunogenicity in mice.
Expression of influenza virus NS2 nonstructural protein in bacteria and localization of NS2 in infected eucaryotic cells.
Expression of the nonstructural protein NS1 of equine influenza A virus: detection of anti-NS1 antibody in post infection equine sera.
Expression of the three influenza virus polymerase proteins in a single cell allows growth complementation of viral mutants.
Expression profiles of interferon-related genes in cells infected with influenza A viruses or transiently transfected with plasmids encoding viral RNA polymerase.
Expression, purification, and characterization of orthomyxovirus: influenza transcriptase.
Favipiravir (T-705) inhibits Junín virus infection and reduces mortality in a guinea pig model of Argentine hemorrhagic fever.
Favipiravir (T-705), a novel viral RNA polymerase inhibitor.
Favipiravir: Pharmacokinetics and Concerns About Clinical Trials for 2019-nCoV Infection.
Fight against H1N1 Influenza A Virus: Recent Insights towards the Development of Druggable Compounds.
Fine mapping of the subunit binding sites of influenza virus RNA polymerase.
Flupyranochromene, a novel inhibitor of influenza virus cap-dependent endonuclease, from Penicillium sp. f28743.
Free Energy Calculations and Binding Analysis of two Potential Anti-Influenza Drugs with Polymerase Basic Protein-2 (PB2).
Functional analysis of conserved motifs in influenza virus PB1 protein.
Functional analysis of influenza RNA polymerase activity by the use of caps, oligonucleotides and polynucleotides.
Functional association between viral and cellular transcription during influenza virus infection.
Functional domains of the influenza A virus PB2 protein: identification of NP- and PB1-binding sites.
Functional Genomics Reveals Linkers Critical for Influenza Virus Polymerase.
G45R mutation in the nonstructural protein 1 of A/Puerto Rico/8/1934 (H1N1) enhances viral replication independent of dsRNA-binding activity and type I interferon biology.
G45R on nonstructural protein 1 of influenza A virus contributes to virulence by increasing the expression of proinflammatory cytokines in mice.
Generation and characterization of influenza A viruses with altered polymerase fidelity.
Generation and comprehensive analysis of an influenza virus polymerase cellular interaction network.
Generation of DelNS1 Influenza Viruses: a Strategy for Optimizing Live Attenuated Influenza Vaccines.
Generation of recombinant influenza virus bearing strep tagged PB2 and effective identification of interactional host factors.
Genetic analysis of the compatibility between polymerase proteins from human and avian strains of influenza A viruses.
Genetic diversity among pandemic 2009 influenza viruses isolated from a transmission chain.
Genetic variation and co-evolutionary relationship of RNA polymerase complex segments in influenza A viruses.
Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins.
Global Reprogramming of Host SUMOylation during Influenza Virus Infection.
Green tea catechins inhibit the endonuclease activity of influenza A virus RNA polymerase.
Growth complementation of influenza virus temperature-sensitive mutants in mouse cells which express the RNA polymerase and nucleoprotein genes.
H9N2 Avian Influenza Virus Protein PB1 Enhances the Immune Responses of Bone Marrow-Derived Dendritic Cells by Down-Regulating miR375.
Hairpin loop structure in the 3' arm of the influenza A virus virion RNA promoter is required for endonuclease activity.
HDAC6 Restricts Influenza A Virus by Deacetylation of the RNA Polymerase PA Subunit.
High-resolution structure of the Influenza A virus PB2cap binding domain illuminates the changes induced by ligand binding.
High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity.
Highlights in the development of new antiviral agents.
Highly pathogenic avian influenza viruses do not inhibit interferon synthesis in infected chickens but can override the interferon-induced antiviral state.
Homology modeling and examination of the effect of the D92E mutation on the H5N1 nonstructural protein NS1 effector domain.
Host ANP32A mediates the assembly of the influenza virus replicase.
Host Determinants of Influenza RNA Synthesis.
Host factor Ebp1: selective inhibitor of influenza virus transcriptase.
Host Interaction Analysis of PA-N155 and PA-N182 in Chicken Cells Reveals an Essential Role of UBA52 for Replication of H5N1 Avian Influenza Virus.
Host Protein Moloney Leukemia Virus 10 (MOV10) Acts as a Restriction Factor of Influenza A Virus by Inhibiting the Nuclear Import of the Viral Nucleoprotein.
Hsp90 inhibitors reduce influenza virus replication in cell culture.
Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle.
Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air.
Human monoclonal single chain antibodies (HuScFv) that bind to the polymerase proteins of influenza A virus.
Human RNA polymerase I-driven reverse genetics for influenza a virus in canine cells.
Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor.
Identification of a novel compound with antiviral activity against influenza A virus depending on PA subunit of viral RNA polymerase.
Identification of host factors that regulate the influenza virus RNA polymerase activity.
Identification of Hsp90 as a stimulatory host factor involved in influenza virus RNA synthesis.
Identification of human-to-human transmissibility factors in PB2 proteins of influenza A by large-scale mutual information analysis.
Identification of the influenza virus transcriptase by affinity-labeling with pyridoxal 5'-phosphate.
Identification of the peptide binding motif for HLA-B44, one of the most common HLA-B alleles in the Caucasian population.
Identification of the RNA polymerase-binding site on genome RNA of influenza virus.
Identification of two nucleotide-binding domains on the PB1 subunit of influenza virus RNA polymerase.
Identification of two separate domains in the influenza virus PB1 protein involved in the interaction with the PB2 and PA subunits: a model for the viral RNA polymerase structure.
Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists.
IgG-neutralized influenza virus undergoes primary, but not secondary uncoating in vivo.
Immunization with live attenuated influenza viruses that express altered NS1 proteins results in potent and protective memory CD8+ T-cell responses.
Immunization with the N-terminal region of the nonstructural protein NS1 promotes survival after challenge with lethal influenza A virus dose.
Immunogenicity of an influenza virus-vectored vaccine carrying the hepatitis C virus protein epitopes in mice.
Immunologic studies on the influenza A virus nonstructural protein NS1.
In vitro assembly of PB2 with a PB1-PA dimer supports a new model of assembly of influenza A virus polymerase subunits into a functional trimeric complex.
In vivo analysis of the promoter structure of the influenza virus RNA genome using a transfection system with an engineered RNA.
In vivo inhibition of influenza A virus replication by RNA interference targeting the PB2 subunit via intratracheal delivery.
Inactivation of influenza and vesicular stomatitis virion RNA polymerase activities by photoreaction with 4'-substituted psoralens.
Individual influenza A virus mRNAs show differential dependence on cellular NXF1/TAP for their nuclear export.
Influence of membrane (M) protein on influenza A virus virion transcriptase activity in vitro and its susceptibility to rimantadine.
Influenza A and B virus intertypic reassortment through compatible viral packaging signals.
Influenza A polymerase subunit PB2 possesses overlapping binding sites for polymerase subunit PB1 and human MAVS proteins.
Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development.
Influenza A virus cap-snatches host RNAs based on their abundance early after infection.
Influenza A virus in vitro transcription: roles of NS1 and NP proteins in regulating RNA synthesis.
Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems.
Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses.
Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses.
Influenza A Virus NS1 Protein Promotes Efficient Nuclear Export of Unspliced Viral M1 mRNA.
Influenza A virus NS1 protein-induced JNK activation and apoptosis are not functionally linked.
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I.
Influenza A virus polymerase: an attractive target for next-generation anti-influenza therapeutics.
Influenza A virus polymerase: structural insights into replication and host adaptation mechanisms.
Influenza A virus progeny vRNP trafficking in live infected cells studied with the virus-encoded fluorescently tagged PB2 protein.
Influenza A virus RNA polymerase has the ability to stutter at the polyadenylation site of a viral RNA template during RNA replication.
Influenza A virus RNA polymerase subunit PB2 is the endonuclease which cleaves host cell mRNA and functions only as the trimeric enzyme.
Influenza A virus RNA-dependent RNA polymerase cleaves influenza mRNA in vitro.
Influenza A virus RNA-dependent RNA polymerase: analysis of RNA synthesis in vitro.
Influenza A virus TRIMs the type I interferon response.
Influenza A virus upregulates PRPF8 gene expression to increase virus production.
Influenza A virus-generated small RNAs regulate the switch from transcription to replication.
Influenza B virus PB1 protein; nucleotide sequence of the genome RNA segment predicts a high degree of structural homology with the corresponding influenza A virus polymerase protein.
Influenza C virus RNA 7 codes for a nonstructural protein.
Influenza chemotherapy: a review of the present state of art and of new drugs in development.
Influenza of age on chromatin transcription in murine tissues using a heterologous and an homologous RNA polymerase.
Influenza polymerase encoding mRNAs utilize atypical mRNA nuclear export.
Influenza Polymerase Inhibitors: Mechanisms of Action and Resistance.
Influenza RNA transcriptase inhibitors: studies in vitro and in vivo.
Influenza RNA-Dependent RNA Polymerase (RdRp) Inhibitors: Potential New Therapy for Influenza Treatment.
Influenza virion RNA-dependent RNA polymerase: stimulation by guanosine and related compounds.
Influenza virion transcriptase: synthesis in vitro of large, polyadenylic acid-containing complementary RNA.
Influenza virion-derived viral ribonucleoproteins synthesize both mRNA and cRNA in vitro.
Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I.
Influenza virus endoribonuclease.
Influenza Virus Exploits an Interferon-Independent lncRNA to Preserve Viral RNA Synthesis through Stabilizing Viral RNA Polymerase PB1.
Influenza virus genome C4 promoter/origin attenuates its transcription and replication activity by the low polymerase recognition activity.
Influenza virus hemagglutinin-specific cytotoxic T cell response induced by polypeptide produced in Escherichia coli.
Influenza virus infection induces cellular Ebp1 gene expression.
Influenza Virus Infection Induces Host Pyruvate Kinase M Which Interacts with Viral RNA-Dependent RNA Polymerase.
Influenza virus inhibits RNA polymerase II elongation.
Influenza virus NS1 protein stimulates translation of the M1 protein.
Influenza virus PB1 protein is the minimal and essential subunit of RNA polymerase.
Influenza virus polymerase inhibitors in clinical development.
Influenza virus polymerase subunits co-evolve to ensure proper levels of dimerization of the heterotrimer.
Influenza virus RNA polymerase may be activated inside the virion.
Influenza virus RNA polymerase PA subunit is a novel serine protease with Ser624 at the active site.
Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis.
Influenza Virus RNA-Dependent RNA Polymerase and the Host Transcriptional Apparatus.
Influenza virus subtype-specific cytotoxic T lymphocytes lyse target cells coated with a protein produced in E. coli.
Influenza viruses and cell membranes.
Inhibition of influenza A virus matrix and nonstructural gene expression using RNA interference.
Inhibition of influenza A virus replication by rifampicin and selenocystamine.
Inhibition of influenza A virus replication by RNA interference targeted against the PB1 subunit of the RNA polymerase gene.
Inhibition of influenza A virus reproduction by a ribozyme targeted against PB1 mRNA.
Inhibition of influenza RNA polymerase by specific antiserum.
Inhibition of influenza virus RNA polymerase and nucleoprotein genes expression by unmodified, phosphorothioated, and liposomally encapsulated oligonucleotides.
Inhibition of influenza virus RNA polymerase and nucleoprotein of gene expression by antisense oligonucleotides.
Inhibition of influenza virus RNA polymerase by 5'-capped short RNA fragments.
Inhibition of influenza virus transcription by 2'-deoxy-2'-fluoroguanosine.
Inhibition of PA endonuclease activity of influenza virus RNA polymerase by Kampo medicines.
Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus.
Inhibition of the influenza virus RNA-dependent RNA polymerase by antisera directed against the carboxy-terminal region of the PB2 subunit.
Inhibition of the particle-associated RNA-dependent RNA polymerase activity of influenza viruses by chelating agents.
Inhibition of the protease activity of influenza virus RNA polymerase PA subunit by viral matrix protein.
Inhibition of transcriptase activity of influenza A virus in vitro by anti-haemagglutinin antibodies.
Inhibitory effect of modified 5'-capped short RNA fragments on influenza virus RNA polymerase gene expression.
Initiation, elongation and realignment during influenza virus mRNA synthesis.
Interaction between anti-influenza viral polymerase antibodies and RNP particles using the in vitro transcription process and an immunogold labelling technique.
Interaction of Host Nucleolin with Influenza A Virus Nucleoprotein in the Early Phase of Infection Limits the Late Viral Gene Expression.
Interaction of the influenza a virus nucleocapsid protein with the viral RNA polymerase potentiates unprimed viral RNA replication.
Interactions between the influenza A virus RNA polymerase components and retinoic acid-inducible gene I.
Interactome Analysis of NS1 Protein Encoded by Influenza A H7N9 Virus Reveals an Inhibitory Role of NS1 in Host mRNA Maturation.
Interactome analysis of the influenza A virus transcription/replication machinery identifies protein phosphatase 6 as a cellular factor required for efficient virus replication.
Internal initiation of influenza virus replication of v- and cRNA in vitro.
Interplay between Influenza Virus and the Host RNA Polymerase II Transcriptional Machinery.
Introduction of site-specific mutations into the genome of influenza virus.
Investigation of Binding Affinity between Potential Antiviral Agents and PB2 Protein of Influenza A: Non-equilibrium Molecular Dynamics Simulation Approach.
Investigation of recombinants of human influenza and fowl plague viruses.
Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits.
Involvement of influenza virus PA subunit in assembly of functional RNA polymerase complexes.
Involvement of the N-terminal portion of influenza virus RNA polymerase subunit PB1 in nucleotide recognition.
In vitro antiviral effects of Peganum harmala seed extract and its total alkaloids against Influenza virus.
Is oseltamivir suitable for fighting against COVID-19: In silico assessment, in vitro and retrospective study.
Isolation and characterization of cytoplasmic inclusions from influenza A virus-infected cells.
Isolation and characterization of the positive-sense replicative intermediate of a negative-strand RNA virus.
Isolation and properties of a temperature-sensitive mutant (ts 412) of an influenza A virus recombinant with a ts lesion in the gene coding for the nonstructural protein.
Isolation and properties of an RNA polymerase from influenza virus-infected cells.
Key role of regulated upon activation normal T-cell expressed and secreted, nonstructural protein1 and myeloperoxidase in cytokine storm induced by influenza virus PR-8 (A/H1N1) infection in A549 bronchial epithelial cells.
La Crosse virus nonstructural protein NSs counteracts the effects of short interfering RNA.
Large-Scale Conformational Dynamics Control H5N1 Influenza Polymerase PB2 Binding to Importin ?.
Learning from our foes: a novel vaccine concept for influenza virus.
Limited compatibility between the RNA polymerase components of influenza virus type A and B.
Mapping of functional domains on the influenza A virus RNA polymerase PB2 molecule using monoclonal antibodies.
Mapping of the influenza virus genome. III. Identification of genes coding for nucleoprotein, membrane protein, and nonstructural protein.
Mapping the domain structure of the influenza A virus polymerase acidic protein (PA) and its interaction with the basic protein 1 (PB1) subunit.
Mechanism for inhibition of influenza virus RNA polymerase activity by matrix protein.
Mechanism of action of T-705 against influenza virus.
Mechanism of action of T-705 ribosyl triphosphate against influenza virus RNA polymerase.
Mesoionic heterocyclic compounds as candidate messenger RNA cap analogue inhibitors of the influenza virus RNA polymerase cap-binding activity.
Messenger RNAs that are not synthesized by RNA polymerase II can be 3' end cleaved and polyadenylated.
Metal ion catalysis of RNA cleavage by the influenza virus endonuclease.
Minimum molecular architectures for transcription and replication of the influenza virus.
Mode of interference of trisodium phosphonoformate (INN: foscarnet sodium), with influenza virus mRNA synthesis.
Mode of replication and temperature characteristics of the RNA polymerase of an influenza virus in vitro.
Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates.
Modulation of mRNA Translation and Cell Viability by Influenza A Virus Derived Nonstructural Protein 1.
Molecular assembly of the influenza virus RNA polymerase: determination of the subunit-subunit contact sites.
Molecular basis of the interaction for an essential subunit PA-PB1 in influenza virus RNA polymerase: insights from molecular dynamics simulation and free energy calculation.
Molecular dissection of influenza virus RNA polymerase: PB1 subunit alone is able to catalyze RNA synthesis.
Molecular mapping of influenza virus RNA polymerase by site-specific antibodies.
Molecular Mechanisms of Tight Binding through Fuzzy Interactions.
mRNA 5'-cap binding activity in purified influenza virus detected by simple, rapid assay.
Multiple amino acid mutations in viral RNA polymerase may synergistically enhance the transmissibility and/or virulence of the 2009 pandemic influenza (H1N1) virus.
Multiplex assay for simultaneously typing and subtyping influenza viruses by use of an electronic microarray.
Mutated influenza A virus exhibiting reduced susceptibility to baloxavir marboxil from an experimentally infected horse.
Mutation in NS2, a nonstructural protein of influenza A virus, extragenically causes aberrant replication and expression of the PA gene and leads to generation of defective interfering particles.
Mutation of an Influenza Virus Polymerase 3' RNA Promoter Binding Site Inhibits Transcription Elongation.
Mutational analyses of the influenza A virus polymerase subunit PA reveal distinct functions related and unrelated to RNA polymerase activity.
Mutational analysis of influenza B virus RNA transcription in vitro.
Mutational analysis of influenza virus promoter elements in vivo.
Mutational analysis of the conserved motifs of influenza A virus polymerase basic protein 1.
Mutational analysis of the influenza virus A/Victoria/3/75 PA protein: studies of interaction with PB1 protein and identification of a dominant negative mutant.
Mutations in influenza virus replication and transcription: detection of amino acid substitutions in hemagglutinin of an avian influenza virus (H1N1).
Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs.
N-Glycans attached to the stem domain of haemagglutinin efficiently regulate influenza A virus replication.
Naturally occurring mutations in PB1 affect influenza A virus replication fidelity, virulence, and adaptability.
New Insight into Metal Ion-Driven Catalysis of Nucleic Acids by Influenza PA-Nter.
New insights into antiviral and cytotoxic potential of quercetin and its derivatives - A biochemical perspective.
NMR spectra of PB2 627, the RNA-binding domain in influenza A virus RNA polymerase that contains the pathogenicity factor lysine 627, and improvement of the spectra by small osmolytes.
Non-structural protein 1 of influenza viruses inhibits rapid mRNA degradation mediated by double-stranded RNA-binding protein, staufen1.
Non-Uniform and Non-Random Binding of Nucleoprotein to Influenza A and B Viral RNA.
Nonstructural protein 1 of influenza A virus interacts with human guanylate-binding protein 1 to antagonize antiviral activity.
NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I.
NS1-Truncated Live Attenuated Virus Vaccine Provides Robust Protection to Aged Mice from Viral Challenge.
NS2 protein of influenza virus is found in purified virus and phosphorylated in infected cells.
Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes.
Nuclear dynamics of influenza A virus ribonucleoproteins revealed by live-cell imaging studies.
Nuclear import and assembly of influenza A virus RNA polymerase studied in live cells by fluorescence cross-correlation spectroscopy.
Nuclear localization of influenza B polymerase proteins and their binary complexes.
Nuclear localized Influenza nucleoprotein N-terminal deletion mutant is deficient in functional vRNP formation.
Nuclear location of all three influenza polymerase proteins and a nuclear signal in polymerase PB2.
Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome.
Nuclear transport of influenza virus polymerase PA protein.
Nucleotides in the panhandle structure of the influenza B virus virion RNA are involved in the specificity between influenza A and B viruses.
Oncolytic activity of a novel influenza A virus carrying GM-CSF in hepatocellular carcinoma.
Open-label study of the safety, pharmacokinetics, and effectiveness of a 2 mg/kg dose of baloxavir marboxil 2% granules in children <20 kg with influenza.
Optimizing antiviral therapy for influenza: understanding the evidence.
PA subunit of RNA polymerase as a promising target for anti-influenza virus agents.
Phenyl substituted 3-hydroxypyridin-2(1H)-ones: Inhibitors of influenza A endonuclease.
Phenyl substituted 4-hydroxypyridazin-3(2H)-ones and 5-hydroxypyrimidin-4(3H)-ones: inhibitors of influenza A endonuclease.
Phosphorylation of Influenza A Virus NS1 at Serine 205 Mediates Its Viral Polymerase-Enhancing Function.
Photoaffinity labeling of influenza virus RNA polymerase PB1 subunit with 8-azido GTP.
Polycistronic Expression of the Influenza A Virus RNA-Dependent RNA Polymerase by Using the Thosea asigna Virus 2A-Like Self-Processing Sequence.
Polyuridylated mRNA synthesized by a recombinant influenza virus is defective in nuclear export.
Possibility of cross-species/subtype reassortments in influenza A viruses: An analysis on nonstructural protein variations.
Potent and broad-spectrum cycloheptathiophene-3-carboxamide compounds that target the PA-PB1 interaction of influenza virus RNA polymerase and possess a high barrier to drug resistance.
Potential role of zinc supplementation in prophylaxis and treatment of COVID-19.
pp32 and APRIL are host cell-derived regulators of influenza virus RNA synthesis from cRNA.
Pre-mRNA Processing Factor Prp18 Is a Stimulatory Factor of Influenza Virus RNA Synthesis and Possesses Nucleoprotein Chaperone Activity.
Precise prediction of a Kk-restricted cytotoxic T cell epitope in the NS1 protein of influenza virus using an MHC allele-specific motif.
Preferential use of RNA leader sequences during influenza A transcription initiation in vivo.
Presence of genomic polyadenylate and absence of detectable virion transcriptase in human coronavirus OC-43.
Priming and inhibitory activities of RNAs for the influenza viral transcriptase do not require base pairing with the virion template RNA.
Priming and realignment by the influenza a virus RdRp is dependent on the length of the host primers and the extent of base pairing to viral RNA.
Probing the impact of quercetin-7-O-glucoside on influenza virus replication influence.
Promoter analysis of influenza virus RNA polymerase.
Proofreading function associated with the RNA-dependent RNA polymerase from influenza virus.
Properties of an RNA polymerase complex detected in influenza virus-infected cells.
Prostate tumor cells infected with a recombinant influenza virus expressing a truncated NS1 protein activate cytolytic CD8+ cells to recognize noninfected tumor cells.
Protective cross-reactive epitope on the nonstructural protein NS1 of influenza A virus.
Protective Immunity Against Homologous and Heterologous Influenza Virus Lethal Challenge by Immunization with New Recombinant Chimeric HA2-M2e Fusion Protein in BALB/C Mice.
Protocol: transmission and prevention of influenza in Hutterites: zoonotic transmission of influenza A: swine & swine workers.
Purification and molecular structure of RNA polymerase from influenza virus A/PR8.
Purification, thioredoxin renaturation, and reconstituted activity of the three subunits of the influenza A virus RNA polymerase.
Real-time analysis of single influenza virus replication complexes reveals large promoter-dependent differences in initiation dynamics.
Rearrangement of Influenza Virus Spliced Segments for the Development of Live-Attenuated Vaccines.
Reassortant Eurasian Avian-Like Influenza A(H1N1) Virus from a Severely Ill Child, Hunan Province, China, 2015.
Recognition of cap structure by influenza B virus RNA polymerase is less dependent on the methyl residue than recognition by influenza A virus polymerase.
Recombinant influenza virus polymerase: requirement of both 5' and 3' viral ends for endonuclease activity.
Recombinant-baculovirus-expressed PB2 subunit of the influenza A virus RNA polymerase binds cap groups as an isolated subunit.
Reconstitution of human rRNA gene transcription in mouse cells by a complete SL1 complex.
Reconstitution of influenza virus RNA polymerase from three subunits expressed using recombinant baculovirus system.
Recruitment of RED-SMU1 complex by Influenza A Virus RNA polymerase to control Ciral mRNA splicing.
Regulation of eukaryotic protein synthesis: selective influenza viral mRNA translation is mediated by the cellular RNA-binding protein GRSF-1.
Regulation of Influenza RNA Polymerase Activity and the Switch between Replication and Transcription by the Concentrations of the vRNA 5' End, the Cap Source, and of the Polymerase.
Regulation of influenza virus RNA polymerase activity by cellular and viral factors.
Relationship between the RNA polymerase activities from influenza virions and influenza virus-infected cells.
Replication and transcription activities of ribonucleoprotein complexes reconstituted from avian H5N1, H1N1pdm09 and H3N2 influenza A viruses.
Replication in vitro of the influenza virus genome: selective dissociation of RNA replicase from virus-infected cell ribonucleoprotein complexes.
Replication-coupled and host factor-mediated encapsidation of the influenza virus genome by viral nucleoprotein.
Rescue of a synthetic chloramphenicol acetyltransferase RNA into influenza virus-like particles obtained from recombinant plasmids.
RNA ligands activate the Machupo virus polymerase and guide promoter usage.
RNA Modulates the Interaction between Influenza A Virus NS1 and Human PABP1.
RNA polymerase I-mediated expression of influenza viral RNA molecules.
RNA polymerase of influenza virus. Dinucleotide-primed initiation of transcription at specific positions on viral RNA.
RNA polymerase of influenza virus. I. Comparison of the virion-associated RNA polymerase activity of various strains of influenza virus.
RNA polymerase of influenza virus. II. Influence of oligonucleotide chain length on the priming activity of RNA synthesis by virion-associated RNA polymerase.
RNA polymerase of influenza virus. III. Isolation of RNA polymerase-RNA complexes from influenza virus PR8.
RNA polymerase of influenza virus. IV. Catalytic properties of the capped RNA endonuclease associated with the RNA polymerase.
RNA polymerase of influenza virus: role of NP in RNA chain elongation.
RNA-binding properties of influenza A virus matrix protein M1.
RNA-dependent activation of primer RNA production by influenza virus polymerase: different regions of the same protein subunit constitute the two required RNA-binding sites.
RNA-dependent RNA polymerase activity in influenza virions.
RNA-dependent RNA polymerase activity of the influenza virus.
RNA-dependent RNA polymerase in nuclei of cells infected with influenza virus.
RNA-Free and Ribonucleoprotein-Associated Influenza Virus Polymerases Directly Bind the Serine-5-Phosphorylated Carboxyl-Terminal Domain of Host RNA Polymerase II.
RNase-like domain in DNA-directed RNA polymerase II.
Role of host protein Ebp1 in influenza virus growth: intracellular localization of Ebp1 in virus-infected and uninfected cells.
Role of human hypoxanthine Guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir).
Role of initiating nucleoside triphosphate concentrations in the regulation of influenza virus replication and transcription.
Role of ran binding protein 5 in nuclear import and assembly of the influenza virus RNA polymerase complex.
Role of TGF-?-activated kinase 1 (TAK1) activation in H5N1 influenza A virus-induced c-Jun terminal kinase activation and virus replication.
Role of the influenza virus heterotrimeric RNA polymerase complex in the initiation of replication.
Role of the PB2 627 Domain in Influenza A Virus Polymerase Function.
Safety and immunogenicity of a recombinant protein influenza A vaccine in adult human volunteers and protective efficacy against wild-type H1N1 virus challenge.
SAR Exploration of Tight Binding Inhibitors of Influenza Virus PA Endonuclease.
SARS-CoV-2 and influenza: a comparative overview and treatment implications.
SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response.
Schizophrenia Susceptibility Genes Directly Implicated in the Life Cycles of Pathogens: Cytomegalovirus, Influenza, Herpes simplex, Rubella, and Toxoplasma gondii.
Screen Anti-influenza Lead Compounds That Target the PA(C) Subunit of H5N1 Viral RNA Polymerase.
Screening for Novel Small-Molecule Inhibitors Targeting the Assembly of Influenza Virus Polymerase Complex by a Bimolecular Luminescence Complementation-Based Reporter System.
Sequence-specific binding of the influenza virus RNA polymerase to sequences located at the 5' ends of the viral RNAs.
Ser624 of the PA subunit of influenza A virus is not essential for viral growth in cells and mice, but required for the maximal viral growth.
Single-molecule FRET reveals a corkscrew RNA structure for the polymerase-bound influenza virus promoter.
Single-molecule FRET reveals the pre-initiation and initiation conformations of influenza virus promoter RNA.
Small interfering RNA targeting the nonstructural gene 1 transcript inhibits influenza A virus replication in experimental mice.
Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase.
Small Variations Between Species/Subtypes Attributed to Reassortment Evidenced from Polymerase Basic Protein 1 with Other Seven Proteins from Influenza A Virus.
Solid phase synthesis of 5'-diphosphorylated oligoribonucleotides and their conversion to capped m7Gppp-oligoribonucleotides for use as primers for influenza A virus RNA polymerase in vitro.
Solution structure of the influenza A virus cRNA promoter: implications for differential recognition of viral promoter structures by RNA-dependent RNA polymerase.
Specific binding of influenza A virus NS1 protein to the virus minus-sense RNA in vitro.
Specific inhibition of influenza virus RNA polymerase and nucleoprotein gene expression by circular dumbbell RNA/DNA chimeric oligonucleotides containing antisense phosphodiester oligonucleotides.
Specific inhibition of influenza virus RNA polymerase and nucleoprotein gene expression by liposomally encapsulated antisense phosphorothioate oligonucleotides in MDCK cells.
Specific inhibition of influenza virus RNA polymerase and nucleoprotein genes expression by liposomally endocapsulated antisense phosphorothioate oligonucleotides: penetration and localization of oligonucleotides in clone 76 cells.
Stabilization of influenza virus replication intermediates is dependent on the RNA-binding but not the homo-oligomerization activity of the viral nucleoprotein.
Structural and Biochemical Analyses on the RNA-dependent RNA Polymerase of Influenza Virus for Development of Novel Anti-influenza Agents.
Structural and computational study on inhibitory compounds for endonuclease activity of influenza virus polymerase.
Structural and Functional Characterization of K339T Substitution Identified in the PB2 Cap-binding Pocket of Influenza A Virus.
Structural basis for dsRNA recognition by NS1 protein of influenza A virus.
Structural basis of the influenza A virus RNA polymerase PB2 RNA-binding domain containing the pathogenicity-determinant lysine 627 residue.
Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5.
structural characterization of the interaction between the C-terminal domain of the influenza polymerase PA subunit and an optimized small peptide inhibitor.
Structural features of an influenza virus promoter and their implications for viral RNA synthesis.
Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase.
Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism.
Structural Mapping of Mutations in Spike, RdRp and Orf3a Genes of SARS-CoV-2 in Influenza Like Illness (ILI) Patients.
Structural snapshots of actively transcribing influenza polymerase.
Structure and Function of the Influenza Virus Transcription and Replication Machinery.
Structure and Sequence Determinants Governing the Interactions of RNAs with Influenza A Virus Non-Structural Protein NS1.
Structure of NS1A effector domain from the influenza A/Udorn/72 virus.
Structure of the iSH2 domain of human phosphatidylinositol 3-kinase p85? subunit reveals conformational plasticity in the interhelical turn region.
Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy.
Structure resolution of the trimeric RNA-dependent RNA polymerase of influenza viruses: impact on our understanding of polymerase interactions with host and viral factors.
Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease.
Structure-based virtual screening of influenza virus RNA polymerase inhibitors from natural compounds: Molecular dynamics simulation and MM-GBSA calculation.
Structure-function relationship of the influenza virus RNA polymerase: primer-binding site on the PB1 subunit.
Structure-function studies of the influenza virus RNA polymerase PA subunit.
Structures of influenza A proteins and insights into antiviral drug targets.
Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
Studies of an influenza A virus temperature-sensitive mutant identify a late role for NP in the formation of infectious virions.
Studies of proteins soluble in acidic chloroform-methanol isolated from crude human leukocyte interferon preparations.
Studies of the Interaction of Influenza Virus RNA Polymerase PAN with Endonuclease Inhibitors.
Studies on the mechanism of neutralization of influenza virus by antibody: evidence that neutralizing antibody (anti-haemagglutinin) inactivates influenza virus in vivo by inhibiting virion transcriptase activity.
Studies on the synthesis of the influenza V virus NB glycoprotein.
Sublingual immunization with a live attenuated influenza a virus lacking the nonstructural protein 1 induces broad protective immunity in mice.
Surface expression of a nonstructural antigen on influenza A virus-infected cells.
Synergistic adaptive mutations in the hemagglutinin and polymerase acidic protein lead to increased virulence of pandemic 2009 H1N1 influenza A virus in mice.
Synthesis and antiviral activity of PB1 component of the influenza A RNA polymerase peptide fragments.
Synthesis and Antiviral Evaluation of Nucleoside Analogues Bearing One Pyrimidine Moiety and Two D-Ribofuranosyl Residues.
Synthesis and biological evaluation of pyrimidine nucleoside monophosphate prodrugs targeted against influenza virus.
Synthesis and In Vitro Evaluation of C-7 and C-8 Luteolin Derivatives as Influenza Endonuclease Inhibitors.
Synthesis and inhibitory effects of novel pyrimido-pyrrolo-quinoxalinedione analogues targeting nucleoproteins of influenza A virus H1N1.
Synthesis and pharmacological studies of some (1,4)-naphthoquinono[3,2-c]-1H-pyrazoles, 2-substituted amino-1,4-naphthoquinones, and related compounds.
Synthesis in vitro of RNA complementary to parental viral RNA by RNA polymerase induced by influenza virus.
Synthesis of 1,2,3-triazolyl nucleoside analogues and their antiviral activity.
Synthesis of a Novel Class of 1,3-oxathiolane Nucleoside Derivatives of T-705 and Evaluation of Their Anti-influenza A Virus and Anti-HIV Activity.
Synthesis of adenylyl-(3'----5')-guanosine and some analogues as probes to explore the molecular mechanism of stimulation of influenza virus RNA polymerase.
Synthesis of biologically active influenza virus core proteins using a vaccinia virus-T7 RNA polymerase expression system.
Synthesis of the NS 2 nonstructural protein messenger RNA of influenza A viruses occurs in the absence of viral protein synthesis.
T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections.
T-705 (Favipiravir) Induces Lethal Mutagenesis in Influenza A H1N1 Viruses In Vitro.
Temperature sensitive influenza A virus genome replication results from low thermal stability of polymerase-cRNA complexes.
Temperature Sensitive Mutations in Influenza A Viral Ribonucleoprotein Complex Responsible for the Attenuation of the Live Attenuated Influenza Vaccine.
Temperature-Sensitive Mutants in the Influenza A Virus RNA Polymerase: Alterations in the PA Linker Reduce Nuclear Targeting of the PB1-PA Dimer and Result in Viral Attenuation.
Temperature-sensitive virion transcriptase activity in mutants of WSN influenza virus.
The active sites of the influenza cap-dependent endonuclease are on different polymerase subunits.
The antiviral activity of tetrazole phosphonic acids and their analogues.
The biology of influenza viruses.
The broad spectrum antiviral ivermectin targets the host nuclear transport importin ?/?1 heterodimer.
The cap-binding site of influenza virus protein PB2 as a drug target.
The Crystal Structure of the PB2 Cap-binding Domain of Influenza B Virus Reveals a Novel Cap Recognition Mechanism.
The Current Recommended Drugs and Strategies for the Treatment of Coronavirus Disease (COVID-19).
The detection and characterization of an induced RNA polymerase in the chorioallantoic membranes of embryonated eggs infected with influenza A2 virus.
The Drift in Molecular Testing for Influenza: Mutations Affecting Assay Performance.
The effect of pyrophosphate analogues on influenza virus RNA polymerase and influenza virus multiplication.
The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus.
The effects of NS gene exchange on the pathogenicity of H5N1 HPAI viruses in ducks.
The fight against the influenza A virus H1N1: synthesis, molecular modeling, and biological evaluation of benzofurazan derivatives as viral RNA polymerase inhibitors.
The fourth genus in the Orthomyxoviridae: sequence analyses of two Thogoto virus polymerase proteins and comparison with influenza viruses.
The Homologous Tripartite Viral RNA Polymerase of A/Swine/Korea/CT1204/2009(H1N2) Influenza Virus Synergistically Drives Efficient Replication and Promotes Respiratory Droplet Transmission in Ferrets.
The in vitro stimulation of the influenza transcriptase by ribosomes.
The influenza A virus proteins PB1 and NS1 are subject to functionally important phosphorylation by protein kinase C.
The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I.
The influenza virus NS1 protein as a therapeutic target.
The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication.
The influenza virus panhandle is involved in the initiation of transcription.
The influenza virus PB1-F2 protein has interferon antagonistic activity.
The influenza virus RNA synthesis machine: Advances in its structure and function.
The inhibition of the RNA polymerase activity of influenza virus A by pyrophosphate analogues.
The interaction of cellular protein ANP32A with influenza A virus polymerase component PB2 promotes vRNA synthesis.
The matrix 1 protein of influenza A virus inhibits the transcriptase activity of a model influenza reporter genome in vivo.
The mechanism of action of T-705 as a unique delayed chain terminator on influenza viral polymerase transcription.
The mechanism of resistance to favipiravir in influenza.
The molecular anatomy of influenza virus RNA polymerase.
The N-terminal extension of the influenza B virus nucleoprotein is not required for nuclear accumulation or the expression and replication of a model RNA.
The N-terminal fragment of a PB2 subunit from the influenza A virus (A/Hong Kong/156/1997 H5N1) effectively inhibits RNP activity and viral replication.
The N-terminal region of influenza virus polymerase PB1 adjacent to the PA binding site is involved in replication but not transcription of the viral genome.
The N-terminal region of the PA subunit of the RNA polymerase of influenza A/HongKong/156/97 (H5N1) influences promoter binding.
The N-terminal residual arginine19 of influenza A virus NS1 protein is required for its nuclear localization and RNA binding.
The novel mitochondria localization of influenza A virus NS1 visualized by FlAsH labeling.
The NS2/NEP Protein Regulates Transcription and Replication of the Influenza Virus RNA Genome.
The ORF, regulated synthesis, and persistence-specific variation of influenza C viral NS1 protein.
The PA influenza virus polymerase subunit is a phosphorylated protein.
The PA subunit is required for efficient nuclear accumulation of the PB1 subunit of the influenza A virus RNA polymerase complex.
The PB1 subunit alone can catalyze cRNA synthesis, and the PA subunit in addition to the PB1 subunit is required for viral RNA synthesis in replication of the influenza virus genome.
The PB2 Subunit of the Influenza A Virus RNA Polymerase Is Imported into the Mitochondrial Matrix.
The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon.
The Polymerase Acidic Protein Gene of Influenza A Virus Contributes to Pathogenicity in a Mouse Model.
The putative polymerase sequence of infectious salmon anemia virus suggests a new genus within the Orthomyxoviridae.
The RNA polymerase of influenza a virus is stabilized by interaction with its viral RNA promoter.
The RNA polymerase of influenza a virus: mechanisms of viral transcription and replication.
The RNA polymerase of influenza virus, bound to the 5' end of virion RNA, acts in cis to polyadenylate mRNA.
The RNA polymerase PB2 subunit is not required for replication of the influenza virus genome but is involved in capped mRNA synthesis.
The RNA Polymerase PB2 Subunit of Influenza A/HongKong/156/1997 (H5N1) Restrict the Replication of Reassortant Ribonucleoprotein Complexes.
The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1? Secretion.
The RNA-dependent RNA polymerase of the influenza A virus.
The role and assembly mechanism of nucleoprotein in influenza A virus ribonucleoprotein complexes.
The role of the influenza virus RNA polymerase in host shut-off.
The role of the priming loop in Influenza A virus RNA synthesis.
The role of the priming loop in influenza A virus RNA synthesis.
The splicing factor proline-glutamine rich (SFPQ/PSF) is involved in influenza virus transcription.
The structural basis for an essential subunit interaction in influenza virus RNA polymerase.
The structure and conformational plasticity of the nonstructural protein 1 of the 1918 influenza A virus.
The structure and synthesis of influenza virus phosphoproteins.
The Surface-Exposed PA51-72-Loop of the Influenza A Virus Polymerase Is Required for Viral Genome Replication.
The synthesis of polypeptides in influenza C virus-infected cells.
The tyrosine 73 and serine 83 dephosphorylation of H1N1 swine influenza virus NS1 protein attenuates virus replication and induces high levels of beta interferon.
The viral mechanism of Reye's syndrome.
Therapy of respiratory viral infections with intranasal siRNAs.
Three-dimensional model for the isolated recombinant influenza virus polymerase heterotrimer.
To Conquer the Host, Influenza Virus Is Packing It In: Interferon-Antagonistic Strategies beyond NS1.
Tools to detect influenza virus.
Toosendanin From Melia Fructus Suppresses Influenza A Virus Infection by Altering Nuclear Localization of Viral Polymerase PA Protein.
Transcriptase activity and genome composition of defective influenza virus.
Transcription of a recombinant influenza virus RNA in cells that can express the influenza virus RNA polymerase and nucleoprotein genes.
Transcription of the influenza ribonucleic acid genome by a virion polymerase. I. Optimal conditions for in vitro activity of the ribonucleic acid-dependent ribonucleic acid polymerase.
Transient bicistronic vRNA segments for indirect selection of recombinant influenza viruses.
Transient expression and sequence of the matrix (M1) gene of WSN influenza A virus in a vaccinia vector.
Translational control by influenza virus. Selective translation is mediated by sequences within the viral mRNA 5'-untranslated region.
Translational regulation of viral secretory proteins by the 5' coding regions and a viral RNA-binding protein.
Treatment-Emergent Influenza Variant Viruses With Reduced Baloxavir Susceptibility: Impact on Clinical and Virologic Outcomes in Uncomplicated Influenza.
TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase.
Two aromatic residues in the PB2 subunit of influenza A RNA polymerase are crucial for cap binding.
Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit.
Two mutations in the C-terminal domain of influenza virus RNA polymerase PB2 enhance transcription by enhancing cap-1 RNA binding activity.
Two nuclear location signals in the influenza virus NS1 nonstructural protein.
Two separate sequences of PB2 subunit constitute the RNA cap-binding site of influenza virus RNA polymerase.
Type I interferon antagonistic properties of influenza B virus polymerase proteins.
Type-IInterferon-Inducible SERTAD3 Inhibits Influenza A Virus Replication by Blocking the Assembly of Viral RNA Polymerase Complex.
Tyr82 Amino Acid Mutation in PB1 Polymerase Induces an Influenza Virus Mutator Phenotype.
U4 at the 3' UTR of PB1 Segment of H5N1 Influenza Virus Promotes RNA Polymerase Activity and Contributes to Viral Pathogenicity.
Ultrastructure of influenza virus ribonucleoprotein complexes during viral RNA synthesis.
Uncoupling of Influenza A Virus Transcription and Replication through Mutation of the Unpaired Adenosine in the Viral RNA Promoter.
Understanding the Binding Transition State After the Conformational Selection Step: The Second Half of the Molecular Recognition Process Between NS1 of the 1918 Influenza Virus and Host p85?.
Unidirectional RNA polymerase I-polymerase II transcription system for the generation of influenza A virus from eight plasmids.
Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors.
Variation in ATP requirement during influenza virus transcription.
Variations outside the conserved motifs of PB1 catalytic active site may affect replication efficiency of the RNP complex of influenza A virus.
Viral RNA polymerase: a promising antiviral target for influenza a virus.
Viral Subpopulation Screening Guides in Designing a High Interferon-Inducing Live Attenuated Influenza Vaccine by Targeting Rare Mutations in NS1 and PB2 Proteins.
Virion transcriptase activity of influenza virus isolates.
Virion transcriptase activity of rimantadine-sensitive and rimantadine-resistant variants of human influenza virus.
Virion-associated transcriptase activity of influenza recombinant and mutant strains.
Virtual Screening and Biological Validation of Novel Influenza Virus PA Endonuclease Inhibitors.
Virucidal effect of sodium p-chloromercuribenzoate on influenza viruses attributable to inhibition of virus particle-associated RNA-dependent RNA polymerase.
Virus-encoded endonucleases: expected and novel functions.
Visualizing the beta interferon response in mice during infection with influenza A viruses expressing or lacking nonstructural protein 1.
What can we learn by computing 13Calpha chemical shifts for X-ray protein models?
X-ray structure of influenza virus NS1 effector domain.
X-ray structures of NS1 effector domain mutants.
[Activity of virion RNA-polymerase in influenza A and B virus variants with different pathogenicities for mice]
[Analysis of genetic variation of hemagglutinin and three internal genes of influenza B virus isolated in Zhejiang province from 1999 to 2012].
[Antisense nucleic acid therapy of influenza virus]
[Antiviral action of sodium selenite and its combination with remantadine]
[Characteristics of the structural organization and transcriptase activity of the influenza virus nucleoid]
[Characterization of RNA polymerase activity of highly purified preparations of influenza virus A/duck/Alberta/48/76]
[Comparative study of the RNA-polymerase activity of non-pathogenic and pathogenic influenza viruses A and B]
[Dynamics of the influenza virus genome regulated by cellular host factors].
[Effect of ribovirine (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboximide) on RNA-dependent RNA-polymerase induction and virus-specific polysome formation in cell cultures infected with influenza A virus]
[Establishment of drug screening assay and pharmacodynamic evaluation method targeting influenza RNA polymerase].
[Function of influenza virus RNA polymerase based on structure]
[Functions of influenza virus RNA polymerase subunits]
[Influenza virus RNA polymerase]
[Inhibition of adenylyl-(3'--5') guanosine-stimulated virion RNA polymerase from influenza A virus by means of adenylyl-(3'--5') virazole]
[Inhibition of influenza virus A RNA-polymerase activity by various 3'-amino-3'-deoxy- and 3'-azido-3'-deoxyribonucleoside-5'-triphosphates]
[Inhibitory action of adenylyl-[3'--5']-ribavirin on the RNA polymerase activity of influenza A viruses]
[Inhibitory effect of 3'-azido-3'-azido-3'-deoxy- ribavirin-5'-triphosphate on RNA synthesis catalyzed by RNA polymerase from influenza A virus and by cellular DNA-dependent RNA polymerase II]
[Inhibitory effect of alpha-methyl-1-adamantane methylamine hydrochloride (rimantadine) on RNA-dependent RNA polymerase induction in culture of cells, infected with influenza virus]
[Inhibitory effect of deoxyadenylyl-(3'-5')-deoxyguanosine on the RNA-polymerase activity of influenza virus A]
[Inhibitory effect of various 3'-amino- and 3'-azido-3'-deoxyribonucleotide-5'-triphosphates on RNA synthesis, catalyzed by RNA polymerase of influenza type A virus and cellular RNA-polymerase]
[Molecular dissection of the influenza virus RNA polymerase]
[Present and future in a development of new anti-influenza drugs]
[Purification and function of RNA dependent RNA polymerase of an influenza virus]
[Recent advance in nonstructural protein of influenza virus A]
[Research progress in molecular determinants of neuraminidase, polymerase basic protein 2 and nonstructural protein 1, related to virulence of influenza A virus--a review].
[RNA transcriptase activity of a defective influenza virus]
[RNA-polymerase activity of pathogenic and nonpathogenic influenza A virus variants]
[Sequence analysis of NS1 gene of some H9N2 subtype influenza viruses isolated from chickens in China]
[Structural and functional aspects of influenza virus RNA polymerase]
[Structure-function relationship of the influenza virus RNA polymerase subunits]
[Structure-function relationship of the influenza virus RNA polymerase]
[The biological effects of coordination compounds of transitional metals. 6. Effect of 4-methyl-2-aminopyridine-palladium chloride and cis-dichlorodiammine-platinum(II) on retroviruses and the virus-associated RNA polymerase of the influenza virus]
Insulin Resistance
Advances in the role of HCV nonstructural protein 5a (NS5A) of 3a genotype in inducing insulin resistance by possible phosphorylation of AKT/PKB.
Hepatitis C virus nonstructural protein 5A favors upregulation of gluconeogenic and lipogenic gene expression leading towards insulin resistance: a metabolic syndrome.
Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis.
Intellectual Disability
A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly(A) tail length.
A Genetic Screen Links the Disease-Associated Nab2 RNA-Binding Protein to the Planar Cell Polarity Pathway in Drosophila melanogaster.
A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies.
A metabolomic and systems biology perspective on the brain of the fragile X syndrome mouse model.
A mouse model of the human Fragile X syndrome I304N mutation.
A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability.
A novel function for fragile X mental retardation protein in translational activation.
A novel role of fragile X mental retardation protein in pre-mRNA alternative splicing through RNA-binding protein 14.
A nuclear role for the Fragile X mental retardation protein.
Advances in understanding of fragile X pathogenesis and FMRP function, and in identification of X linked mental retardation genes.
Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome.
Analysis of FMRP mRNA target datasets reveals highly associated mRNAs mediated by G-quadruplex structures formed via clustered WGGA sequences.
Biology of the fragile X mental retardation protein, an RNA-binding protein.
Cells lacking the fragile X mental retardation protein (FMRP) have normal RISC activity but exhibit altered stress granule assembly.
Characterization of fragile X mental retardation protein recruitment and dynamics in Drosophila stress granules.
CYFIP family proteins between autism and intellectual disability: links with Fragile X syndrome.
Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR.
Delayed stabilization of dendritic spines in fragile X mice.
Deletion of the KH1 Domain of Fmr1 Leads to Transcriptional Alterations and Attentional Deficits in Rats.
Developmentally-programmed FMRP expression in oligodendrocytes: a potential role of FMRP in regulating translation in oligodendroglia progenitors.
Differential regulation of BK channels by fragile X mental retardation protein.
Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs.
Dissecting FMR1, the protein responsible for fragile X syndrome, in its structural and functional domains.
Dynamic Association of the Fragile X Mental Retardation Protein as a Messenger Ribonucleoprotein between Microtubules and Polyribosomes.
Dynamics of the fragile X mental retardation protein correlates with cellular and synaptic properties in primary auditory neurons following afferent deprivation.
Dysregulation and restoration of translational homeostasis in fragile X syndrome.
Expression of MicroRNA machinery proteins in different types of chronic rhinosinusitis.
FMRP acts as a key messenger for dopamine modulation in the forebrain.
FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association.
FMRP interferes with the Rac1 pathway and controls actin cytoskeleton dynamics in murine fibroblasts.
FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A.
FMRP regulates miR196a-mediated repression of HOXB8 via interaction with the AGO2 MID domain.
FMRP regulates neurogenesis in vivo in Xenopus laevis tadpoles.
FMRP regulates the transition from radial glial cells to intermediate progenitor cells during neocortical development.
FMRP targets distinct mRNA sequence elements to regulate protein expression.
Fragile mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes.
Fragile X mental retardation protein (FMRP) and metabotropic glutamate receptor subtype 5 (mGlu5) control stress granule formation in astrocytes.
Fragile X mental retardation protein (FMRP) binds specifically to the brain cytoplasmic RNAs BC1/BC200 via a novel RNA-binding motif.
Fragile X mental retardation protein (FMRP) interacting proteins exhibit different expression patterns during development.
Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack.
Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors.
Fragile X Mental Retardation protein determinants required for its association with polyribosomal mRNPs.
Fragile X Mental Retardation Protein expression in the retina is regulated by light.
Fragile X mental retardation protein induces synapse loss through acute postsynaptic translational regulation.
Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses.
Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b.
Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2.
Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets.
Fragile X mental retardation protein regulates accumulation of the active zone protein Munc18-1 in presynapses via local translation in axons during synaptogenesis.
Fragile X mental retardation protein regulates new neuron differentiation in the adult olfactory bulb.
Fragile X mental retardation protein regulates olfactory sensitivity but not odorant discrimination.
Fragile X mental retardation protein regulates synaptic and behavioral plasticity to repeated cocaine administration.
Fragile X mental retardation protein shifts between polyribosomes and stress granules after neuronal injury by arsenite stress or in vivo hippocampal electrode insertion.
Fragile X mental retardation protein-regulated proinflammatory cytokine expression in the spinal cord contributes to the pathogenesis of inflammatory pain induced by complete Freund's adjuvant.
Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes.
Fragile X mental retardation: misregulation of protein synthesis in the developing brain?
Fragile X protein controls neural stem cell proliferation in the Drosophila brain.
Fragile X protein FMRP is required for homeostatic plasticity and regulation of synaptic strength by retinoic acid.
Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus.
Fragile X Syndrome: From molecular pathology to therapy.
FRAXE-associated mental retardation protein (FMR2) is an RNA-binding protein with high affinity for G-quartet RNA forming structure.
FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells.
GABAB receptor upregulates fragile X mental retardation protein expression in neurons.
Handling FMRP and its molecular partners: Structural insights into Fragile X Syndrome.
Heads-up: New roles for the fragile X mental retardation protein in neural stem and progenitor cells.
HITS-CLIP in various brain areas reveals new targets and new modalities of RNA binding by fragile X mental retardation protein.
Identification of consensus binding sites clarifies FMRP binding determinants.
Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/?-catenin, and mTOR signaling during corticogenesis.
Identification of fragile X syndrome specific molecular markers in human fibroblasts: a useful model to test the efficacy of therapeutic drugs.
Identification of mouse YB1/p50 as a component of the FMRP-associated mRNP particle.
Identity of the RNA-binding protein K of hnRNP particles with protein H16, a sequence-specific single strand DNA-binding protein.
Imbalance of synaptic actin dynamics as a key to fragile X syndrome?
Increased Cardiac Arrhythmogenesis Associated With Gap Junction Remodeling With Upregulation of RNA-Binding Protein FXR1.
Interactions of the G quartet forming semaphorin 3F RNA with the RGG box domain of the fragile X protein family.
Involvement of FMRP in Primary MicroRNA Processing via Enhancing Drosha Translation.
Involvement of Phosphodiesterase 2A Activity in the Pathophysiology of Fragile X Syndrome.
Kinase pathway inhibition restores PSD95 induction in neurons lacking fragile X mental retardation protein.
Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes.
Linking the Fragile X mental retardation protein to the lipoxygenase pathway.
Lost once, the Fragile X Mental Retardation protein is now back onto brain polyribosomes.
Low-normal FMR1 CGG repeat length: phenotypic associations.
Metabotropic glutamate receptors and fragile x mental retardation protein: partners in translational regulation at the synapse.
Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome.
Methylation regulates the intracellular protein-protein and protein-RNA interactions of FMRP.
Modeling Fragile X Syndrome in Drosophila.
Modelling fragile X syndrome in the laboratory setting: A behavioral perspective.
Modulation of dendritic spines and synaptic function by Rac1: a possible link to Fragile X syndrome pathology.
Molecular and Cellular Aspects of Mental Retardation in the Fragile X Syndrome: From Gene Mutation/s to Spine Dysmorphogenesis.
mRNA and protein expression for novel GABAA receptors ? and ?2 are altered in schizophrenia and mood disorders; relevance to FMRP-mGluR5 signaling pathway.
Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95.
Multiple Gq-coupled receptors converge on a common protein synthesis-dependent long-term depression that is affected in fragile X syndrome mental retardation.
Muscle-Specific FXR1 Isoforms in Squamous Cell Cancer.
Neuronal activity drives FMRP- and HSPG-dependent matrix metalloproteinase function required for rapid synaptogenesis.
New Insights Into the Role of Cav2 Protein Family in Calcium Flux Deregulation in Fmr1-KO Neurons.
On BC1 RNA and the fragile X mental retardation protein.
Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting.
Phosphorylation of FMRP inhibits association with Dicer.
Post-translational modifications of the Fragile X Mental Retardation Protein in neuronal function and dysfunction.
Postsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity.
Proteomic analyses of nucleus laminaris identified candidate targets of the fragile X mental retardation protein.
Proteomic analysis reveals CCT is a target of Fragile X mental retardation protein regulation in Drosophila.
Quantitative phosphoproteomics of murine Fmr1-KO cell lines provides new insights into FMRP-dependent signal transduction mechanisms.
Quantitative profiling of brain lipid raft proteome in a mouse model of fragile X syndrome.
Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice.
Regulation of molecular pathways in the Fragile X Syndrome: insights into Autism Spectrum Disorders.
Regulation of neuronal excitability by interaction of fragile X mental retardation protein with slack potassium channels.
Reward-Related Expectations Trigger Dendritic Spine Plasticity in the Mouse Ventrolateral Orbitofrontal Cortex.
RNA and microRNAs in fragile X mental retardation.
Role of FMRP in rapid antidepressant effects and synapse regulation.
Roles of fragile X mental retardation protein in dopaminergic stimulation-induced synapse-associated protein synthesis and subsequent alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) receptor internalization.
S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade.
Semaphorin-3A Promotes Degradation of Fragile X Mental Retardation Protein in Growth Cones via the Ubiquitin-Proteasome Pathway.
SnapShot: FMRP mRNA targets and diseases.
Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex.
Structural and Functional Abnormalities in the Olfactory System of Fragile X Syndrome Models.
Targeting NUFIP1 Suppresses Growth and Induces Senescence of Colorectal Cancer Cells.
Targeting the endocannabinoid system in the treatment of fragile X syndrome.
Temporal-specific roles of fragile X mental retardation protein in the development of the hindbrain auditory circuit.
The chicken FMR1 gene is highly conserved with a CCT 5'-untranslated repeat and encodes an RNA-binding protein.
The FMRP regulon: from targets to disease convergence.
The FMRP/GRK4 mRNA interaction uncovers a new mode of binding of the Fragile X mental retardation protein in cerebellum.
The fragile X mental retardation protein FMRP binds elongation factor 1A mRNA and negatively regulates its translation in vivo.
The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules.
The fragile X mental retardation protein promotes adjustments in cocaine self-administration that preserve reinforcement level.
The Fragile X Mental Retardation Protein Regulates Striatal Medium Spiny Neuron Synapse Density and Dendritic Spine Morphology.
The fragile X mental retardation protein, FMRP, recognizes G-quartets.
The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development.
The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer.
The gene encoding the fragile X RNA-binding protein is controlled by nuclear respiratory factor 2 and the CREB family of transcription factors.
The Human Fragile X Mental Retardation Protein Inhibits the Elongation Step of Translation through Its RGG and C-Terminal Domains.
The nuclear MicroSpherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons.
The RNA-binding protein FMRP facilitates the nuclear export of N6-methyladenosine-containing mRNAs.
The RNA-binding protein Nab2 regulates the proteome of the developing Drosophila brain.
The RNA-binding protein, ZC3H14, is required for proper poly(A) tail length control, expression of synaptic proteins, and brain function in mice.
The RNA-binding proteins FMR1, rasputin and caprin act together with the UBA protein lingerer to restrict tissue growth in Drosophila melanogaster.
The Search for an Effective Therapy to Treat Fragile X Syndrome: Dream or Reality?
The translational regulator FMRP controls lipid and glucose metabolism in mice and humans.
Toward fulfilling the promise of molecular medicine in fragile X syndrome.
Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression.
Understanding fragile X syndrome: insights from animal models.
Widespread Alterations in Translation Elongation in the Brain of Juvenile Fmr1 Knockout Mice.
Intervertebral Disc Degeneration
RNA-Binding Protein HuR Suppresses Inflammation and Promotes Extracellular Matrix Homeostasis via NKRF in Intervertebral Disc Degeneration.
RNA-binding protein HuR suppresses senescence through Atg7 mediated autophagy activation in diabetic intervertebral disc degeneration.
Iron Deficiencies
Differences in the regulation of iron regulatory protein-1 (IRP-1) by extra- and intracellular oxidative stress.
Post-transcriptional regulation of iron homeostasis in Saccharomyces cerevisiae.
Ischemic Stroke
Characterization of the transient middle cerebral artery occlusion model of ischemic stroke in a HuR transgenic mouse line.
Extracellular CIRP Activates the IL-6R?/STAT3/Cdk5 Pathway in Neurons.
Monocyte function and plasma levels of interleukin-8 in acute ischemic stroke.
RNPS1 inhibition aggravates ischemic brain injury and promotes neuronal death.
Transgenic expression of HuR increases vasogenic edema and impedes functional recovery in rodent ischemic stroke.
Joint Diseases
Integrated Diagnosis Project for Inflammatory Myopathies: An association between autoantibodies and muscle pathology.
Prevalence of antibodies to human parvovirus B19 nonstructural protein in persons with various clinical outcomes following B19 infection.
Skeletal Muscle Involvement in Antisynthetase Syndrome.
[Antisynthetase myopathy].
Keloid
Heat Shock Protein 90 Inhibitor Decreases Collagen Synthesis of Keloid Fibroblasts and Attenuates the Extracellular Matrix on the Keloid Spheroid Model.
Keratitis
16S Ribosomal RNA PCR Versus Conventional Diagnostic Culture in the Investigation of Suspected Bacterial Keratitis.
Keratosis, Actinic
Expression of Cold-Inducible RNA-Binding Protein in Normal Skin, Actinic Keratosis and Squamous Cell Carcinoma.
Kernicterus
Bilirubin encephalopathy: effect on RNA polymerase activity and chromatin template activity in the brain of the Gunn rat.
Kidney Diseases
Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis.
WT1 and kidney progenitor cells.
Kidney Diseases, Cystic
Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6.
Role of the RNA-binding protein Bicaudal-C1 and interacting factors in cystic kidney diseases.
Kidney Neoplasms
The expression of RNA-binding protein RBM38 decreased in renal cell carcinoma and represses renal cancer cell proliferation, migration, and invasion.
Langerhans Cell Sarcoma
The Expression of Insulin-Like Growth Factor 2 Messenger RNA-Binding Protein 3 in Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma.
Lassa Fever
The Lassa fever virus L gene: nucleotide sequence, comparison, and precipitation of a predicted 250 kDa protein with monospecific antiserum.
Legionnaires' Disease
The alternative sigma factor sigma28 of Legionella pneumophila restores flagellation and motility to an Escherichia coli fliA mutant.
Leprosy
Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in Mycobacterium leprae.
Leprosy, Lepromatous
Molecular basis of rifampin resistance in Mycobacterium leprae.
Leukemia
A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.
BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription.
Capture of antigen-specific T lymphocytes from human blood by selective immortalization to establish long-term T-cell lines maintaining primary cell characteristics.
Cooperative translational control of polymorphic BAFF by NF90 and miR-15a.
Deoxyribonucleic acid-dependent ribonucleic acid polymerases from spleen of uninfected and Rauscher murine leukemia virus-infected NIH Swiss mice.?
Differential inhibition of various deoxyribonucleic acid polymerases by Evans blue and aurintricarboxylic acid.
Differential inhibition of various deoxyribonucleic and ribonucleic acid polymerases by suramin.
Effect of antineoplastic and cytotoxic Mannich Bases derived from conjugated styryl ketones on mitochondrial respiration in rat liver cells.
Effect of Rauscher leukemia virus-specific proteins on reverse transcriptase. Binding between reverse transcriptase and p30.
Effects of streptovaricins and their degradation products on RNA-directed DNA polymerase of Rauscher leukemia virus.
EWS represses cofilin 1 expression by inducing nuclear retention of cofilin 1 mRNA.
Expression of EVI1 in myelodysplastic syndromes and other hematologic malignancies without 3q26 translocations.
Fusion protein EWS-FLI1 is incorporated into a protein granule in cells.
Immunohistochemical evaluation of reverse transcriptase in breast carcinoma with polyclonal antibodies raised in rabbit.
Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework.
Interaction of N-trifluoroacetyladriamycin-14-O-hemiadipate with chicken leukemia RNA polymerase. Formation of drug-enzyme complex.
Intrinsic properties of reverse transcriptase in reverse transcription. Associated RNase H is essentially regarded as an endonuclease.
Long noncoding RNA PART1 restrains aggressive gastric cancer through the epigenetic silencing of PDGFB via the PLZF-mediated recruitment of EZH2.
Male sterility and enhanced radiation sensitivity in TLS(-/-) mice.
Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.
Nucleolin and the packaging signal, psi, promote the budding of human immunodeficiency virus type-1 (HIV-1).
Promyelocytic leukemia isoform IV confers resistance to encephalomyocarditis virus via the sequestration of 3D polymerase in nuclear bodies.
Regulation of c-jun expression during induction of monocytic differentiation by okadaic acid.
Retargeting Polyomavirus-Like Particles to Cancer Cells by Chemical Modification of Capsid Surface.
Reverse transcriptase. The use of cloned Moloney murine leukemia virus reverse transcriptase to synthesize DNA from RNA.
RNA polymerase activity following infection with murine leukemia virus.
RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1.
RNA-dependent DNA polymerase activity in ocular granulocytic sarcoma associated to acute myelomonocytic leukemia in Turkish children. Biochemical and immunological characterization of the enzyme.
Role of cellular RNA polymerases in virus-induced leukemogenesis.
Selective immortalization of tumor-specific T cells to establish long-term T-cell lines maintaining primary cell characteristics.
Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II-dependent pathway in human K562 leukemia cells.
The RNA-binding protein IGF2BP3 is critical for MLL-AF4-mediated leukemogenesis.
The RNA-binding protein IMP-3 is a translational activator of insulin-like growth factor II leader-3 mRNA during proliferation of human K562 leukemia cells.
Leukemia, Erythroblastic, Acute
Accurate initiation of human epsilon-globin RNA synthesis by Escherichia coli RNA polymerase in isolated nuclei of K562 erythroleukemia cells.
Cytoplasmic synthesis of globin RNA in differentiated murine erythroleukemia cells: possible involvement of RNA-dependent RNA polymerase.
Study of the role of retinoblastoma protein in terminal differentiation of murine erythroleukemia cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Tryptophanyl transfer RNA synthetase from lymphocytes of human chronic lymphocytic leukemia.
Leukemia, Lymphoid
Antitumor agents. XXXIV: Mechanism of action of bruceoside A and brusatol on nucleic acid metabolism of P-388 lymphocytic leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23).
Detection of the BCR/ABL fusion gene in chronic myeloid leukemia by RNA polymerase chain reaction.
High levels of the BCR/ABL oncoprotein are required for the MAPK-hnRNP-E2 dependent suppression of C/EBPalpha-driven myeloid differentiation.
[Detection of tumor load in chronic myeloid leukemia during treatment with transplantation by conventional cytogenetics, nested-RT-PCR and FISH]
Leukemia, Myeloid
An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia.
An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation.
Musashi 2 contributes to the stemness and chemoresistance of liver cancer stem cells via LIN28A activation.
Leukemia, Myeloid, Acute
MicroRNA-519 enhances HL60 human acute myeloid leukemia cell line proliferation by reducing the expression level of RNA-binding protein human antigen R.
Musashi-2 Silencing Exerts Potent Activity against Acute Myeloid Leukemia and Enhances Chemosensitivity to Daunorubicin.
Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia.
Leukemia, T-Cell
Capture of antigen-specific T lymphocytes from human blood by selective immortalization to establish long-term T-cell lines maintaining primary cell characteristics.
Transcriptional activation of RNA polymerase III-dependent genes by the human T-cell leukemia virus type 1 tax protein.
Leukoencephalopathies
Immunoenzymatic labelling of JC papovavirus T antigen in brains of patients with progressive multifocal leukoencephalopathy.
Leukoencephalopathy, Progressive Multifocal
Immunoenzymatic labelling of JC papovavirus T antigen in brains of patients with progressive multifocal leukoencephalopathy.
Leukoplakia
Heterogeneous ribonucleoprotein K is a marker of oral leukoplakia and correlates with poor prognosis of squamous cell carcinoma.
Leukoplakia, Oral
Heterogeneous ribonucleoprotein K is a marker of oral leukoplakia and correlates with poor prognosis of squamous cell carcinoma.
Lichen Planus
A retrospective case-control study of hepatitis C virus infection and oral lichen planus in Japan: association study with mutations in the core and NS5A region of hepatitis C virus.
Lichen Planus, Oral
A retrospective case-control study of hepatitis C virus infection and oral lichen planus in Japan: association study with mutations in the core and NS5A region of hepatitis C virus.
Lipodystrophy
Cutaneous toxicities of antiretroviral therapy for HIV: part I. Lipodystrophy syndrome, nucleoside reverse transcriptase inhibitors, and protease inhibitors.
Liposarcoma
A protein-protein interaction of stress-responsive myosin VI endowed to inhibit neural progenitor self-replication with RNA binding protein, TLS, in murine hippocampus.
Arginine methylation of translocated in liposarcoma (TLS) inhibits its binding to long noncoding RNA, abrogating TLS-mediated repression of CBP/p300 activity.
Characterization of a Family of RanBP2-Type Zinc Fingers that Can Recognize Single-Stranded RNA.
Elevated FUS/TLS expression is negatively associated with E-cadherin expression and prognosis of patients with non-small cell lung cancer.
FUS/TLS as a polyglutamine aggregate interacting protein.
Male sterility and enhanced radiation sensitivity in TLS(-/-) mice.
NEAT1 is Required for Survival of Breast Cancer Cells Through FUS and miR-548.
RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells.
The RNA-binding Protein Fused in Sarcoma (FUS) Functions Downstream of Poly(ADP-ribose) Polymerase (PARP) in Response to DNA Damage.
Liposarcoma, Myxoid
A renal cell carcinoma with EWSR1-TFE3 fusion gene.
An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation.
CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability.
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.
Induction of a secreted protein by the myxoid liposarcoma oncogene.
Liver Cirrhosis
Aberrant expression of fetal RNA-binding protein p62 in liver cancer and liver cirrhosis.
Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells.
Effect of mutation in the hepatitis C virus nonstructural 5B region on HCV replication.
Genotype 3-hepatitis C virus' last line of defense.
linc-SCRG1 accelerates liver fibrosis by decreasing RNA-binding protein tristetraprolin.
RNA-binding protein RBMS3 is expressed in activated hepatic stellate cells and liver fibrosis and increases expression of transcription factor Prx1.
TAF and TDF attenuate liver fibrosis through NS5ATP9, TGF?1/Smad3, and NF-?B/NLRP3 inflammasome signaling pathways.
THE EFFECT OF STEM CELLS AS AN ADJUVANT ON THE IMMUNOGENICITY OF A POTENTIAL ANTI-SCHISTOSOMAL VACCINE IN MICE.
Liver Cirrhosis, Alcoholic
Identification of beta-subunit of bacterial RNA-polymerase--a non-species-specific bacterial protein--as target of antibodies in primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Identification of beta-subunit of bacterial RNA-polymerase--a non-species-specific bacterial protein--as target of antibodies in primary biliary cirrhosis.
[Autoantibodies of Inflammatory Myopathies: Update].
Liver Diseases
Assessment of hepatitis C virus RNA levels by quantitative competitive RNA polymerase chain reaction: high-titer viremia correlates with advanced stage of disease.
Clinical evaluation of three anti-HCV ELISAs in patients with various liver diseases.
Genetic and biochemical diversity in the HCV NS5B RNA polymerase in the context of interferon alpha plus ribavirin therapy.
HCV Genotype 6a Escape from and Resistance to Velpatasvir, Pibrentasvir, and Sofosbuvir in Robust Infectious Cell Culture Models.
In situ enzymatic oligonucleotide amplification of hepatitis C virus-RNA in liver biopsy specimens (reverse transcriptase in situ polymerase chain reaction) after orthotopic liver transplantation for hepatitis C-related liver disease.
Outcome of All-Oral Direct-Acting Antiviral Regimens on the Rate of Development of Hepatocellular Carcinoma in Patients with Hepatitis C Virus Genotype 1-Related Chronic Liver Disease.
SIRT1 mediates the role of RNA-binding protein QKI 5 in the synthesis of triglycerides in non-alcoholic fatty liver disease mice via the PPAR?/FoxO1 signaling pathway.
Liver Failure, Acute
Detection of hepatitis C virus with RNA polymerase chain reaction in fulminant hepatic failure.
Urgent liver transplantation for nevirapine-induced acute liver failure: report of a case and review of the literature.
Liver Neoplasms
Aberrant expression of fetal RNA-binding protein p62 in liver cancer and liver cirrhosis.
Cold-inducible RNA-binding protein promotes the development of liver cancer.
Hepatitis C virus nonstructural 5A protein inhibits the starvation?induced apoptosis of hepatoblastoma cells by increasing Beclin 1 expression.
Identification of an immune-related RNA-binding protein signature to predict survival and targeted therapy responses in liver cancer.
RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts.
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program.
Liver Neoplasms, Experimental
Isolation and characterization of nonhistone chromosomal protein C-14 which stimulates RNA synthesis.
Nucleolar and extranucleolar chromatin of rat Novikoff hepatoma cells. Separation and partial characterization of RNA polymerase activities.
Lung Diseases, Interstitial
A case of macrophage activation syndrome in a patient with anti-synthetase syndrome.
Anti-synthetase syndrome: a new autoantibody to phenylalanyl transfer RNA synthetase (anti-Zo) associated with polymyositis and interstitial pneumonia.
Antisynthetase Syndrome with Anti-Jo1 Antibodies in 48 Patients: Pulmonary Involvement Predicts Disease-modifying Antirheumatic Drug Use.
Association of anti-aminoacyl-transfer RNA synthetase antibody and anti-melanoma differentiation-associated gene 5 antibody with the therapeutic response of polymyositis/dermatomyositis-associated interstitial lung disease.
Clinical features of anti-synthetase syndrome associated interstitial lung disease: a retrospective cohort in China.
Clinical manifestations and outcome of anti-aminoacyl-transfer RNA synthetase antibody and anti-melanoma differentiation-associated gene 5 antibody positive patients with interstitial lung disease.
Clinicopathological analysis of mechanic's hand associated with dermatomyositis.
Integrated Diagnosis Project for Inflammatory Myopathies: An association between autoantibodies and muscle pathology.
Mechanic's hand; is it a prodromic sign of disease relapse of anti-synthetase syndrome; a case report.
Skeletal Muscle Involvement in Antisynthetase Syndrome.
The Diagnosis and Treatment of Antisynthetase Syndrome.
The pulmonary histopathologic manifestations of the anti-PL7/antithreonyl transfer RNA synthetase syndrome.
The pulmonary histopathology of anti-KS transfer RNA synthetase syndrome.
Treatment of antisynthetase-associated interstitial lung disease with tacrolimus.
[Antisynthetase myopathy].
[Antisynthetase syndrome: a retrospective study of 14 patients].
Lung Injury
Attenuation of hemorrhage-associated lung injury by adjuvant treatment with C23, an oligopeptide derived from cold-inducible RNA-binding protein (CIRP).
Attenuation of hemorrhage-associated lung injury by adjuvant treatment with C23, an oligopeptide derived from cold-inducible RNA-binding protein.
C23, an oligopeptide derived from cold-inducible RNA-binding protein, suppresses inflammation and reduces lung injury in neonatal sepsis.
Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress.
Luteolin Suppresses Sepsis-Induced Cold-Inducible Rna-Binding Protein Production and Lung Injury in Neonatal MICE.
Mir-331-3p Inhibits PRRSV-2 Replication and Lung Injury by Targeting PRRSV-2 ORF1b and Porcine TNF-?.
Lung Neoplasms
Alpha CP-4, encoded by a putative tumor suppressor gene at 3p21, but not its alternative splice variant alpha CP-4a, is underexpressed in lung cancer.
Application of Serum ELAVL4 (HuD) Antigen Assay for Small Cell Lung Cancer Diagnosis.
Elevated FUS/TLS expression is negatively associated with E-cadherin expression and prognosis of patients with non-small cell lung cancer.
Expression of TARBP1 protein in human non-small-cell lung cancer and its prognostic significance.
Expression profile, clinical significance, and biological function of insulin-like growth factor 2 messenger RNA-binding proteins in non-small cell lung cancer.
Heterogeneous nuclear ribonucleoprotein B1 expression in malignant mesothelioma.
HnRNP-L promotes prostate cancer progression by enhancing cell cycling and inhibiting apoptosis.
Increased expression of insulin-like growth factor-II messenger RNA-binding protein 1 is associated with tumor progression in patients with lung cancer.
KH-type splicing regulatory protein (KHSRP) contributes to tumorigenesis by promoting miR-26a maturation in small cell lung cancer.
L523S, an RNA-binding protein as a potential therapeutic target for lung cancer.
MUC1-C Induces the LIN28B?LET-7?HMGA2 Axis to Regulate Self-Renewal in NSCLC.
Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC).
QKI-5 regulates the alternative splicing of cytoskeletal gene ADD3 in lung cancer.
Quaking orchestrates a post-transcriptional regulatory network of endothelial cell cycle progression critical to angiogenesis and metastasis.
Replicase-based plasmid DNA shows anti-tumor activity.
RNA-binding motif protein 10 induces apoptosis and suppresses proliferation by activating p53.
RNA-binding protein KHSRP promotes tumor growth and metastasis in non-small cell lung cancer.
RNA-binding Protein Trinucleotide repeat-containing 6A Regulates the Formation of Circular RNA 0006916, with Important Functions in Lung Cancer Cells.
RNA-binding Protein, GADD45-alpha, p27(Kip1), p53 and Genotoxic Stress Response in Relation to Chemoresistance in Cancer.
Role of RNA-binding protein 5 in the diagnosis and chemotherapeutic response of lung cancer.
The Expression of RNA-Binding Protein HuR in Non-Small Cell Lung Cancer Correlates with Vascular Endothelial Growth Factor-C Expression and Lymph Node Metastasis.
The oncogenic RNA-binding protein SRSF1 regulates LIG1 in non-small cell lung cancer.
The RNA-binding protein HuR stabilizes the cytosolic phospholipase A2{alpha} mRNA under interleukin-1{beta} treatment in non-small cell lung cancer A549 cells.
The RNA-Binding Protein QKI Suppresses Cancer-Associated Aberrant Splicing.
The RNA-binding protein Sam68 is critical for non-small cell lung cancer cell proliferation by regulating Wnt/?-catenin pathway.
The RNA-binding protein SART3 promotes miR-34a biogenesis and G1 cell cycle arrest in lung cancer cells.
Tumor-specific activation of human telomerase reverses transcriptase promoter activity by activating enhancer-binding protein-2beta in human lung cancer cells.
Lupus Erythematosus, Cutaneous
The Ro 60 kDa autoantigen comes into focus: interpreting epitope mapping experiments on the basis of structure.
Lupus Erythematosus, Systemic
A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen.
Developmental characterization of a Drosophila RNA-binding protein homologous to the human systemic lupus erythematosus-associated La/SS-B autoantigen.
Identification of beta-subunit of bacterial RNA-polymerase--a non-species-specific bacterial protein--as target of antibodies in primary biliary cirrhosis.
Phage-displayed La/SS-B antigen as a diagnostic reagent.
Scleroderma-specific autoantibodies embedded in immune complexes mediate endothelial damage: an early event in the pathogenesis of systemic sclerosis.
Sensitivity and specificity of anti-Jo-1 antibodies in autoimmune diseases with myositis.
The RNA binding protein La/SS-B promotes RIG-I-mediated type I and type III IFN responses following Sendai viral infection.
The Ro 60 kDa autoantigen comes into focus: interpreting epitope mapping experiments on the basis of structure.
The Ro 60 kDa autoantigen: insights into cellular function and role in autoimmunity.
The Root Extract of Gentiana macrophylla Pall. Alleviates B19-NS1-Exacerbated Liver Injuries in NZB/W F1 Mice.
Lupus Nephritis
Anti-RNA polymerase I antibodies: potential role in the induction and progression of murine lupus nephritis.
Lyme Disease
Borrelia burgdorferi SpoVG DNA- and RNA-Binding Protein Modulates the Physiology of the Lyme Disease Spirochete.
Transcript decay mediated by RNase III in Borrelia burgdorferi.
Lymphatic Metastasis
Diffuse expression of RNA-binding protein IMP3 predicts high-stage lymph node metastasis and poor prognosis in colorectal adenocarcinoma.
Long non-coding RNA Loc490 inhibits gastric cancer cell proliferation and metastasis by upregulating RNA-binding protein Quaking.
The Expression of RNA-Binding Protein HuR in Non-Small Cell Lung Cancer Correlates with Vascular Endothelial Growth Factor-C Expression and Lymph Node Metastasis.
Lymphocytic Choriomeningitis
A Highly Conserved Leucine In Mammarenavirus Matrix Z Protein Is Required For Z Interaction With The Virus L Polymerase And Z Stability In Cells Harboring An Active Viral Ribonucleoprotein.
Antiviral protective immunity induced by major histocompatibility complex class I molecule-restricted viral T-lymphocyte epitopes inserted in various positions in immunologically self and nonself proteins.
Detection of virus-specific RNA-dependent RNA polymerase activity in extracts from cells infected with lymphocytic choriomeningitis virus: in vitro synthesis of full-length viral RNA species.
DNA-based immunisation against rabies and rabies-related viruses: towards multivalent vaccines.
The primary structure of the lymphocytic choriomeningitis virus L gene encodes a putative RNA polymerase.
Lymphoma
CREB targets define the gene expression signature of malignancies having reduced levels of the tumor suppressor tristetraprolin.
Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death.
Increased IL-6 detection in adult and pediatric lymphoid tissue harboring Parvovirus B19.
Nucleoproteins derived from subnuclear RNA polymerase complexes of metastatic large-cell lymphoma cells possess transcription activities and regulatory properties in vitro.
Participation of poly(ADP-ribosyl)ation in the depression of RNA synthesis caused by treatment of mouse lymphoma cells with methylnitrosourea.
Lymphoma, B-Cell
Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death.
Long non-coding RNA DBH-AS1 promotes cancer progression in diffuse large B-cell lymphoma by targeting FN1 via RNA-binding protein BUD13.
The Eµ-hnRNP K Murine Model of Lymphoma: Novel Insights into the Role of hnRNP K in B-Cell Malignancies.
Uncovering the role of hnRNP K, an RNA-binding protein, in B-cell lymphomas.
Lymphoma, Large B-Cell, Diffuse
Long non-coding RNA DBH-AS1 promotes cancer progression in diffuse large B-cell lymphoma by targeting FN1 via RNA-binding protein BUD13.
Lymphoma, Non-Hodgkin
DNA-dependent RNA polymerases of Ehrlich carcinoma, other murine ascites tumors, and murine normal tissues.
Lymphoma, T-Cell
Interleukin-5 mRNA in three T-cell lymphomas with eosinophilia.
Lymphoproliferative Disorders
Hepatitis C virus upregulates B-cell receptor signaling: a novel mechanism for HCV-associated B-cell lymphoproliferative disorders.
Macular Degeneration
Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38
Malaria
A circular DNA in malaria parasites encodes an RNA polymerase like that of prokaryotes and chloroplasts.
Identification of beta-subunit of bacterial RNA-polymerase--a non-species-specific bacterial protein--as target of antibodies in primary biliary cirrhosis.
PfAlba1: master regulator of translation in the malaria parasite.
RNA-binding protein-related sequence in a malaria antigen, clustered-asparagine-rich protein.
The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase.
The malaria parasite Plasmodium falciparum encodes members of the Puf RNA-binding protein family with conserved RNA binding activity.
The Puf-family RNA-binding protein PfPuf2 regulates sexual development and sex differentiation in the malaria parasite Plasmodium falciparum.
The Puf-family RNA-binding protein Puf2 controls sporozoite conversion to liver stages in the malaria parasite.
Marek Disease
Improving the potency of DNA vaccine against Chicken Anemia Virus (CAV) by fusing VP1 protein of CAV to Marek's Disease Virus (MDV) Type-1 VP22 protein.
Massive Hepatic Necrosis
Analysis of hepatitis A virus protein 2B in sera of hepatitis A of various severities.
Genetic analysis of HAV strains in Tunisia reveals two new antigenic variants.
Mastitis
The clinical impact of antimicrobial resistance genomics in competition with she-camels recurrent mastitis metabolomics due to heterogeneous
Measles
A microcapillary column switching HPLC-electrospray ionization MS system for the direct identification of peptides presented by major histocompatibility complex class I molecules.
An amino-proximal domain of the L protein binds to the P protein in the measles virus RNA polymerase complex.
Cancer and Virus Leads by HTS, Chemical Design and SEA Data Mining.
Characterization of an RNA-dependent RNA polymerase activity associated with measles virus.
Characterization of in vitro transcription and transcriptional products of measles virus.
Hemagglutinin protein is a primary target of the measles virus-specific HLA-A2-restricted CD8+ T cell response during measles and after vaccination.
Host cell proteins required for measles virus reproduction.
Measles virus L protein evidences elements of ancestral RNA polymerase.
Measles Virus Nonstructural C Protein Modulates Viral RNA Polymerase Activity by Interacting with Host Protein SHCBP1.
Measles virus nucleocapsid protein can function in Sendai virus defective interfering particle genome synthesis in vitro.
Modulating the function of the measles virus RNA-dependent RNA polymerase by insertion of green fluorescent protein into the open reading frame.
Mutations in the measles virus C protein that up regulate viral RNA synthesis.
Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex activity: Synthesis and in vitro evaluation.
Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: synthesis, structure-activity relationships, and pharmacokinetics.
Nonnucleoside inhibitor of measles virus RNA-dependent RNA polymerase complex activity.
Phosphorylation of measles virus phosphoprotein at S86 and/or S151 downregulates viral transcriptional activity.
Potent non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex.
Sequence variability and function of measles virus 3' and 5' ends and intercistronic regions.
Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling.
Signature motifs of GDP polyribonucleotidyltransferase, a non-segmented negative strand RNA viral mRNA capping enzyme, domain in the L protein are required for covalent enzyme-pRNA intermediate formation.
Study of transcription in measles virus-infected Vero cells using cDNA probes prepared from poly(A)RNA from uninfected and infected cells.
Target analysis of the experimental measles therapeutic AS-136A.
The C Protein Is Recruited to Measles Virus Ribonucleocapsids by the Phosphoprotein.
The matrix protein of measles virus regulates viral RNA synthesis and assembly by interacting with the nucleocapsid protein.
The phosphoprotein (P) and L binding sites reside in the N-terminus of the L subunit of the measles virus RNA polymerase.
The structurally disordered paramyxovirus nucleocapsid protein tail domain is a regulator of the mRNA transcription gradient.
Therapeutic targeting of measles virus polymerase with ERDRP-0519 suppresses all RNA synthesis activity.
Vesicular Stomatitis Virus Phosphoprotein Dimerization Domain Is Dispensable for Virus Growth.
Medulloblastoma
Anti-apoptotic activity of Japanese encephalitis virus NS5 protein in human medulloblastoma cells treated with interferon-?.
Inhibition of Long Noncoding RNA CRNDE Increases Chemosensitivity of Medulloblastoma Cells by Targeting miR-29c-3p.
The RNA-Binding Protein Musashi1 Affects Medulloblastoma Growth via a Network of Cancer-Related Genes and Is an Indicator of Poor Prognosis.
YBX1 Indirectly Targets Heterochromatin-Repressed Inflammatory Response-Related Apoptosis Genes through Regulating CBX5 mRNA.
Melanoma
A renal cell carcinoma with EWSR1-TFE3 fusion gene.
Crystal structure of the human heterogeneous ribonucleoprotein A18 RNA-recognition motif.
Dose-Dependent Inhibition of Melanoma Differentiation-Associated Gene 5-Mediated Activation of Type I Interferon Responses by Methyltransferase of Hepatitis E Virus.
Drug-induced expression of the RNA-binding protein HuR attenuates the adaptive response to BRAF inhibition in melanoma.
Dual mechanisms of action of the RNA-binding protein human antigen R explains its regulatory effect on melanoma cell migration.
Expression of the wt1 Wilms' tumor gene by normal and malignant human melanocytes.
Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis.
High RBM3 expression in prostate cancer independently predicts a reduced risk of biochemical recurrence and disease progression.
HUR protects NONO from degradation by mir320, which is induced by p53 upon UV irradiation.
Insulin-Like Growth Factor II mRNA-Binding Protein 3 Expression Correlates with Poor Prognosis in Acral Lentiginous Melanoma.
microRNA-340-mediated degradation of microphthalmia-associated transcription factor (MITF) mRNA is inhibited by coding region determinant binding protein (CRD-BP).
MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor (MITF) mRNA is inhibited by coding region determinant-binding protein (CRD-BP).
Overexpression of mRNA-binding protein CRD-BP in malignant melanomas.
The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma.
The RNA-binding protein MEX3B mediates resistance to cancer immunotherapy by downregulating HLA-A expression.
West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5.
Melanoma, Experimental
Replicase-based plasmid DNA shows anti-tumor activity.
[The mechanism of anti-tumor immune response against mouse melanoma to xenogeneic vaccination]
Memory Disorders
Associative and spatial learning and memory deficits in transgenic mice overexpressing the RNA-binding protein HuD.
Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation.
Meningioma
Cytoplasmic overexpression of RNA-binding protein HuR is a marker of poor prognosis in meningioma, and HuR knockdown decreases meningioma cell growth and resistance to hypoxia.
Functional analysis of an alternatively spliced estrogen receptor lacking exon 4 isolated from MCF-7 breast cancer cells and meningioma tissue.
Meningitis, Aseptic
Genomic characterization of echovirus 6 causing aseptic meningitis in Hokkaido, Japan: a novel cluster in the nonstructural protein coding region of human enterovirus B.
Natural genetic recombination between co-circulating heterotypic enteroviruses.
Phylogenetic analysis of Echovirus 30 isolated during the 2005 outbreak in France reveals existence of multiple lineages and suggests frequent recombination events.
Meningitis, Fungal
Characterizing the role of RNA silencing components in Cryptococcus neoformans.
Mental Retardation, X-Linked
Modulation of neuritogenesis by a protein implicated in X-linked mental retardation.
Metabolic Diseases
Circular RNAs are a novel type of non-coding RNAs in ROS regulation, cardiovascular metabolic inflammations and cancers.
Metabolic Syndrome
Hepatitis C virus nonstructural protein 5A favors upregulation of gluconeogenic and lipogenic gene expression leading towards insulin resistance: a metabolic syndrome.
Metrorrhagia
Chimeras between oilseed rape mosaic virus and tobacco mosaic virus highlight the relevant role of the tobamoviral RdRp as pathogenicity determinant in several hosts.
Microcephaly
Congenital Visual Impairment and Progressive Microcephaly Due to Lysyl-Transfer Ribonucleic Acid (RNA) Synthetase (KARS) Mutations: The Expanding Phenotype of Aminoacyl-Transfer RNA Synthetase Mutations in Human Disease.
Microphthalmos
Functional Role of the RNA-Binding Protein Rbm24a and Its Target sox2 in Microphthalmia.
Molluscum Contagiosum
Similarity in genome organization between Molluscum contagiosum virus (MCV) and vaccinia virus (VV): identification of MCV homologues of the VV genes for protein kinase 2, structural protein VP8, RNA polymerase 35 kDa subunit and 3beta-hydroxysteroid dehydrogenase.
Motor Neuron Disease
ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.
Mechanism of karyopherin-?2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X).
Senataxin, A Novel Helicase at the Interface of RNA Transcriptome Regulation and Neurobiology: From Normal Function to Pathological Roles in Motor Neuron Disease and Cerebellar Degeneration.
The Small-Molecule Flunarizine in Spinal Muscular Atrophy Patient Fibroblasts Impacts on the Gemin Components of the SMN Complex and TDP43, an RNA-Binding Protein Relevant to Motor Neuron Diseases.
Mouth Diseases
(F)uridylylated Peptides Linked to VPg1 of Foot-and- Mouth Disease Virus (FMDV): Design, Synthesis and X-Ray Crystallography of the Complexes with FMDV RNA-Dependent RNA Polymerase.
Development of a recombinant vaccine against foot and mouth disease utilizing mutant attenuated Listeria ivanovii strain as a live vector.
Development of synthetic peptide ELISA based on nonstructural protein 2C of foot and mouth disease virus.
Expression of enterovirus 71 capsid protein VP1 in Escherichia coli and its clinical application.
GITRL as a genetic adjuvant enhances enterovirus 71 VP1 DNA vaccine immunogenicity.
Homology Modeling and Analysis of Structure Predictions of the Bovine Rhinitis B Virus RNA Dependent RNA Polymerase (RdRp).
Improved immunogenicity of a peptide epitope after fusion to hepatitis B core protein.
Indirect ELISA using recombinant nonstructural protein 3D to detect foot and mouth disease virus infection associated antibodies.
Induction of active immune suppression by co-immunization with DNA- and protein-based vaccines.
Inhibitors of foot and mouth disease virus targeting a novel pocket of the RNA-dependent RNA polymerase.
Isolation of novel sequences targeting highly variable viral protein hemagglutinin.
Molecular characterization of amino acid deletion in VP1 (1D) protein and novel amino acid substitutions in 3D polymerase protein of foot and mouth disease virus subtype A/Iran87.
Orientation of epitopes influences the immunogenicity of synthetic peptide dimers.
Purification and immunogenicity of fusion VP1 protein of foot and mouth disease virus.
Radioimmunoassay for detection of VP1 specific neutralizing antibodies of foot and mouth disease virus.
The plasmid constructs producing shRNA corresponding to the conserved 3D polymerase of Foot and Mouth Disease virus protects guinea pigs against challenge virus.
[Development and characterization of monoclonal antibodies against VP1 protein of AsiaI type foot-and-mouth virus]
[Molecular basis of changes in biological properties of foot and mouth disease virus of subtype A22]
[Primary structure of the A22 RNA polymerase gene of the foot and mouth disease virus]
[Synthesis of new fragments of VP1 protein fragments from foot and mouth disease virus type A22. Synthesis of fragments 134-139, 134-145, 140-145, 150-155, and 150-159]
Mouth Neoplasms
Overexpression of RNA-binding protein CELF1 prevents apoptosis and destabilizes pro-apoptotic mRNAs in oral cancer cells.
Multiple Myeloma
Cyclin-dependent kinase inhibitor, P276-00 induces apoptosis in multiple myeloma cells by inhibition of Cdk9-T1 and RNA polymerase II-dependent transcription.
IL-6-induced enhancement of c-myc translation in multiple myeloma cells: critical role of cytoplasmic localization of the RNA-binding protein hnRNP A1.
IL-6-induced stimulation of c-myc translation in multiple myeloma cells is mediated by myc internal ribosome entry site function and the RNA-binding protein, hnRNP A1.
Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1.
Multiple Sclerosis
Antibodies to the RNA-binding protein hnRNP A1 contribute to neurodegeneration in a model of central nervous system autoimmune inflammatory disease.
Dysfunctional RNA-binding protein biology and neurodegeneration in experimental autoimmune encephalomyelitis in female mice.
Neuronal RNA-binding protein dysfunction in multiple sclerosis cortex.
Polymerase-1 pathway activation in acute multiple sclerosis relapse.
Targeting the RNA-Binding Protein HuR Alleviates Neuroinflammation in Experimental Autoimmune Encephalomyelitis: Potential Therapy for Multiple Sclerosis.
Unraveling a new player in multiple sclerosis pathogenesis: The RNA-binding protein HuR.
Mumps
Protein domain definition should allow for conditional disorder.
RNA polymerase in mumps virion.
The R2TP complex regulates paramyxovirus RNA synthesis.
Viruses within the Flaviviridae decrease CD4 expression and inhibit HIV replication in human CD4+ cells.
Muscle Cramp
Cathelicidin antimicrobial peptides suppress EV71 infection via regulating antiviral response and inhibiting viral binding.
Muscular Atrophy
A de novo c.1509dupA:p.R503fs mutation of FUS: report of a girl with sporadic juvenile amyotrophic lateral sclerosis.
Muscle-specific Expression of the RNA-binding Protein Staufen1 Induces Progressive Skeletal Muscle Atrophy via Regulation of Phosphatase Tensin Homolog.
Muscular Atrophy, Spinal
The Small-Molecule Flunarizine in Spinal Muscular Atrophy Patient Fibroblasts Impacts on the Gemin Components of the SMN Complex and TDP43, an RNA-Binding Protein Relevant to Motor Neuron Diseases.
Muscular Diseases
Abnormal expression of RNA polymerase II-associated proteins in muscle of patients with myofibrillar myopathies.
Developmental regulation of muscleblind-like (MBNL) gene expression in the chicken embryo retina.
Immune Myopathy With Perimysial Pathology Associated With Interstitial Lung Disease and Anti-EJ Antibodies.
Loss of RNA-Binding Protein Sfpq Causes Long-Gene Transcriptopathy in Skeletal Muscle and Severe Muscle Mass Reduction with Metabolic Myopathy.
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.
Muscular Dystrophies
Myo-granules Connect Physiology and Pathophysiology.
Point mutations in the dystrophin gene: evidence for frequent use of cryptic splice sites as a result of splicing defects.
Muscular Dystrophies, Limb-Girdle
Myofibrillar disruption and RNA-binding protein aggregation in a mouse model of limb-girdle muscular dystrophy 1D.
Muscular Dystrophy, Oculopharyngeal
pH-dependent self-assembly of polyalanine peptides.
Myalgia
Haemolytic anaemia precipitated by dengue fever.
Mycoses
An automated high throughput filtration assay: application to polymerase inhibitor identification.
Control of brown patch (Rhizoctonia solani) in tall fescue (Festuca arundinacea Schreb.) by host induced gene silencing.
Molecular cloning and characterization of an inducible RNA-dependent RNA polymerase gene, GhRdRP, from cotton (Gossypium hirsutum L.).
Myelodysplastic Syndromes
Expression of EVI1 in myelodysplastic syndromes and other hematologic malignancies without 3q26 translocations.
RNA-binding protein (RBFOX1) inherited polymorphism rs8051518 is not associated with splice factor mutations in myelodysplastic syndromes and myeloproliferative neoplasms.
Myocardial Ischemia
CIRBP protects H9C2 cells against myocardial ischemia through inhibition of NF-?B pathway.
Myocarditis
Characterization of polyclonal antibodies against the capsid proteins of Ljungan virus.
CVB3 Nonstructural 2A Protein Modulates SREBP1a Signaling via the MEK/ERK Pathway.
Enteroviral RNA replication in the myocardium of patients with left ventricular dysfunction and clinically suspected myocarditis.
Intein-mediated backbone cyclization of VP1 protein enhanced protection of CVB3-induced viral myocarditis.
Proteome alterations in human host cells infected with coxsackievirus B3.
Myoclonus
Novel POLR1C mutation in RNA polymerase III-related leukodystrophy with severe myoclonus and dystonia.
Myoepithelioma
Cutaneous syncytial myoepithelioma: A case report with emphasis on the differential diagnosis of problematic dermal tumors.
Myositis
A case of macrophage activation syndrome in a patient with anti-synthetase syndrome.
A rare association of anti-alanine-transfer RNA synthetase (anti-PL12) syndrome and sporadic inclusion body myositis.
Antibody to threonyl-transfer RNA synthetase in myositis sera.
Antisynthetase Syndrome with Anti-Jo1 Antibodies in 48 Patients: Pulmonary Involvement Predicts Disease-modifying Antirheumatic Drug Use.
Clinical features of anti-synthetase syndrome associated interstitial lung disease: a retrospective cohort in China.
Complete spinal cord involvement from neuromyelitis optica spectrum disorder in an adult female with anti-synthetase syndrome.
Cutaneous manifestations of dermatomyositis characterized by myositis-specific autoantibodies.
In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype.
Integrated Diagnosis Project for Inflammatory Myopathies: An association between autoantibodies and muscle pathology.
Mechanic's hand; is it a prodromic sign of disease relapse of anti-synthetase syndrome; a case report.
Mizoribine treatment in an elderly diabetic patient with antisynthetase-associated interstitial lung disease.
Myo-granules Connect Physiology and Pathophysiology.
Skeletal Muscle Involvement in Antisynthetase Syndrome.
Statins and myotoxic effects associated with anti-3-hydroxy-3-methylglutaryl-coenzyme a reductase autoantibodies: an observational study in Japan.
The clinical phenotype associated with myositis-specific and associated autoantibodies: A meta-analysis revisiting the so-called antisynthetase syndrome.
The Diagnosis and Treatment of Antisynthetase Syndrome.
Treatment of antisynthetase-associated interstitial lung disease with tacrolimus.
[Antisynthetase myopathy].
[Antisynthetase syndrome: a retrospective study of 14 patients].
[Autoantibodies of Inflammatory Myopathies: Update].
Myositis, Inclusion Body
A rare association of anti-alanine-transfer RNA synthetase (anti-PL12) syndrome and sporadic inclusion body myositis.
Myo-granules Connect Physiology and Pathophysiology.
[Autoantibodies of Inflammatory Myopathies: Update].
Myotonic Dystrophy
Altered phosphorylation and intracellular distribution of a (CUG)n triplet repeat RNA-binding protein in patients with myotonic dystrophy and in myotonin protein kinase knockout mice.
Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy.
CELF1 Mediates Connexin 43 mRNA Degradation in Dilated Cardiomyopathy.
Correction of RNA-Binding Protein CUGBP1 and GSK3? Signaling as Therapeutic Approach for Congenital and Adult Myotonic Dystrophy Type 1.
Developmental regulation of muscleblind-like (MBNL) gene expression in the chicken embryo retina.
Elevation of RNA-binding protein CUGBP1 is an early event in an inducible heart-specific mouse model of myotonic dystrophy.
Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy.
Inhibition of cyclooxygenase-1 by nonsteroidal anti-inflammatory drugs demethylates MeR2 enhancer and promotes Mbnl1 transcription in myogenic cells.
LDB3 splicing abnormalities are specific to skeletal muscles of patients with myotonic dystrophy type 1 and alter its PKC binding affinity.
Nuclear localization of MBNL1: splicing-mediated autoregulation and repression of repeat-derived aberrant proteins.
Repeat recognition.
Staufen1s role as a splicing factor and a disease modifier in Myotonic Dystrophy Type I.
The RNA-binding protein CUGBP1 regulates stability of tumor necrosis factor mRNA in muscle cells: implications for myotonic dystrophy.
Myxoma
A myxoma virus nucleotide sequence with homology to the vaccinia virus RNA polymerase 22-kDa subunit gene.
RNA Polymerase Mutations Selected during Experimental Evolution Enhance Replication of a Hybrid Vaccinia Virus with an Intermediate Transcription Factor Subunit Replaced by the Myxoma Virus Ortholog.
Nasal Polyps
Cold-inducible RNA-binding protein contributes to tissue remodeling in chronic rhinosinusitis with nasal polyps.
Expression of MicroRNA machinery proteins in different types of chronic rhinosinusitis.
Nasopharyngeal Carcinoma
Loss of Cirbp expression is correlated with the malignant progression and poor prognosis in nasopharyngeal carcinoma.
RBM24 suppresses cancer progression by upregulating miR-25 to target MALAT1 in nasopharyngeal carcinoma.
RNA-binding protein YBX1 promotes cell proliferation and invasiveness of nasopharyngeal carcinoma cells via binding to AURKA mRNA.
Neonatal Sepsis
C23, an oligopeptide derived from cold-inducible RNA-binding protein, suppresses inflammation and reduces lung injury in neonatal sepsis.
Neoplasm Metastasis
An RNA-binding protein, Hu-antigen R, in pancreatic cancer epithelial to mesenchymal transition, metastasis, and cancer stem cells.
Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study.
Anti-Cancer Stem Cells Potentiality of an Anti-Malarial Agent Quinacrine: An Old Wine in a New Bottle.
Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing.
CircRNA circFOXK2 facilitates oncogenesis in breast cancer via IGF2BP3/miR-370 axis.
Clinicopathological Significance of TARBP2, APP, and ZNF395 in Breast Cancer.
CPEB1 mediates hepatocellular carcinoma cancer stemness and chemoresistance.
CSDE1 controls gene expression through the miRNA-mediated decay machinery.
Diffuse expression of RNA-binding protein IMP3 predicts high-stage lymph node metastasis and poor prognosis in colorectal adenocarcinoma.
EIF4E regulates STEAP1 expression in peritoneal metastasis.
Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis.
Heterogeneous nuclear ribonucleoprotein A2/B1 is a negative regulator of human breast cancer metastasis by maintaining the balance of multiple genes and pathways.
HNRNPLL stabilizes mRNA for DNA replication proteins and promotes cell cycle progression in colorectal cancer cells.
IMP3 RNP Safe Houses Prevent miRNA-Directed HMGA2 mRNA Decay in Cancer and Development.
Invasive growth associated with Cold-Inducible RNA-Binding Protein expression drives recurrence of surgically resected brain metastases.
Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein.
Long non-coding RNA Loc490 inhibits gastric cancer cell proliferation and metastasis by upregulating RNA-binding protein Quaking.
Long non-coding RNAs: a rising biotarget in colorectal cancer.
Msi1 promotes breast cancer metastasis by regulating invadopodia-mediated extracellular matrix degradation via the Timp3-Mmp9 pathway.
Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC).
Prognostic alternative splicing regulatory network of RBM25 in hepatocellular carcinoma.
RBMS1 Suppresses Colon Cancer Metastasis through Targeted Stabilization of Its mRNA Regulon.
RNA-binding protein KHSRP promotes tumor growth and metastasis in non-small cell lung cancer.
RNA-binding protein SORBS2 suppresses clear cell renal cell carcinoma metastasis by enhancing MTUS1 mRNA stability.
Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis.
The Expression of RNA-Binding Protein HuR in Non-Small Cell Lung Cancer Correlates with Vascular Endothelial Growth Factor-C Expression and Lymph Node Metastasis.
The function of the RNA-binding protein hnRNP in cancer metastasis.
The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma.
The non-reverse transcriptase activity of the human telomerase reverse transcriptase promotes tumor progression (review).
The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing.
The RNA-binding protein HuR inhibits expression of CCL5 and limits recruitment of macrophages into tumors.
The RNA-Binding Protein NELFE Promotes Gastric Cancer Growth and Metastasis Through E2F2.
The RNA-binding protein RBM47 inhibits non-small cell lung carcinoma metastasis through modulation of AXIN1 mRNA stability and Wnt/?-catentin signaling.
The RNA-binding protein SORBS2 suppresses hepatocellular carcinoma tumourigenesis and metastasis by stabilizing RORA mRNA.
The stability and oncogenic function of LIN28A are regulated by USP28.
Zinc finger RNA-binding protein promotes non-small-cell carcinoma growth and tumor metastasis by targeting the Notch signaling pathway.
[Relationship between expression of RBM38 and distant metastasis and prognosis of breast cancer].
Neoplasm Micrometastasis
The clinical importance of a transcription reverse-transcription concerted (TRC) diagnosis using peritoneal lavage fluids in gastric cancer with clinical serosal invasion: a prospective, multicenter study.
Neoplasms
1-(3-C-Ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106), a novel potent inhibitor of RNA polymerase, potentiates the cytotoxicity of CDDP in human cancer cells both in vitro and in vivo.
3p21.3 tumor suppressor gene RBM5 inhibits growth of human prostate cancer PC-3 cells through apoptosis.
A dead end for microRNAs.
A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells.
A global integrated analysis of UNC5C down-regulation in cancers: insights from mechanism and combined treatment strategy.
A novel RNA-binding protein, Ossa/C9orf10, regulates activity of Src kinases to protect cells from oxidative stress-induced apoptosis.
A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy.
A proposed reverse transcription mechanism for (CAG)n and similar expandable repeats that cause neurological and other diseases.
A renal cell carcinoma with EWSR1-TFE3 fusion gene.
A SMYD3 Small-Molecule Inhibitor Impairing Cancer Cell Growth.
Abnormal expression of TFIIIB subunits and RNA Pol III genes is associated with hepatocellular carcinoma.
AC-Caps: Attention Based Capsule Network for Predicting RBP Binding Sites of LncRNA.
Accelerated onset of viral transcription in adenovirus-infected HeLa cells treated with the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate.
Activation of monocytes by three OspA vaccine candidates: lipoprotein OspA is a potent stimulator of monokines.
Active Center Control of Termination by RNA Polymerase III and tRNA Gene Transcription Levels In Vivo.
Advances at the Interface of Cancer and Systemic Sclerosis.
Alpha CP-4, encoded by a putative tumor suppressor gene at 3p21, but not its alternative splice variant alpha CP-4a, is underexpressed in lung cancer.
Altered chaperone and protein turnover regulators expression in cultured skin fibroblasts from type 1 diabetes mellitus with nephropathy.
An antimutagenic metabolite, streptovaricin C, isolated from Streptomyces sp.
An emerging role for nuclear RNA-mediated responses to genotoxic stress.
An Integrative Drug Repurposing Pipeline: Switching Viral Drugs to Breast Cancer.
An OTU deubiquitinating enzyme in Eimeria tenella interacts with Eimeria tenella virus RDRP.
An RNA-binding protein, Hu-antigen R, in pancreatic cancer epithelial to mesenchymal transition, metastasis, and cancer stem cells.
ANOVA, a putative astrocytic RNA-binding protein gene that maps to chromosome 19q13.3.
Anti-cancer effects of the HuR inhibitor, MS-444, in malignant glioma cells.
Anti-Cancer Stem Cells Potentiality of an Anti-Malarial Agent Quinacrine: An Old Wine in a New Bottle.
Antigenically active nonhistone chromatin proteins in cancer cells.
Antitumor activity of tumor-targeted RNA replicase-based plasmid that expresses interleukin-2 in a murine melanoma model.
Antiviral protective immunity induced by major histocompatibility complex class I molecule-restricted viral T-lymphocyte epitopes inserted in various positions in immunologically self and nonself proteins.
Applying a high-throughput fluorescence polarization assay for the discovery of chemical probes blocking La:RNA interactions in vitro and in cells.
Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression.
Arid5a: A Missing Link between EMT and Tumoral Immune Resistance.
Binding of Escherichia coli RNA polymerase to a specific site located near the 3'-end of the avaian sarcoma virus genome.
Bioinformatics analysis identifies potential chemoresistance-associated genes across multiple types of cancer.
Biological Roles and Mechanisms of Circular RNA in Human Cancers.
Biphasic and Stage-Associated Expression of CPEB4 in Hepatocellular Carcinoma.
BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration.
BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1.
CDK1 dependent phosphorylation of hTERT contributes to cancer progression.
Che-1 is targeted by c-Myc to sustain proliferation in pre-B-cell acute lymphoblastic leukemia.
CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability.
Chromatin-directed Ribonucleic Acid Synthesis: A Comparison of Chromatins Isolated from Healthy, Avirulent Agrobacterium tumefaciens Inoculated, and Crown-Gall Tumor Tissues of Vicia faba.
CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs.
Circular RNA La-related RNA-binding protein 4 correlates with reduced tumor stage, as well as better prognosis, and promotes chemosensitivity to doxorubicin in breast cancer.
Circular RNAs are a novel type of non-coding RNAs in ROS regulation, cardiovascular metabolic inflammations and cancers.
Circular RNAs function as competing endogenous RNAs in multiple types of cancer.
Circular RNAs: Characteristics, function, and role in human cancer.
Close temporal relationship between onset of cancer and scleroderma in patients with RNA polymerase I/III antibodies.
Combined inhibition of RNA polymerase I and mTORC1/2 synergize to combat oral squamous cell carcinoma.
Comparative analysis of inducible expression systems in transient transfection studies.
Compensatory RNA polymerase 2 loading determines the efficacy and transcriptional selectivity of JQ1 in Myc-driven tumors.
Complex HuR function in pancreatic cancer cells.
Computer-Aided Discovery of Small Molecules Targeting the RNA Splicing Activity of hnRNP A1 in Castration-Resistant Prostate Cancer.
Control of parvovirus DNA replication by a tetracycline-regulated repressor.
Correction for Bhowmick et al., "Rotavirus-Encoded Nonstructural Protein 1 Modulates Cellular Apoptotic Machinery by Targeting Tumor Suppressor Protein p53".
Correction for Gabai et al., "Heat Shock Transcription Factor Hsf1 Is Involved in Tumor Progression via Regulation of Hypoxia-Inducible Factor 1 and RNA-Binding Protein HuR".
Cortisone inhibition of nuclear RNA polymerase of the human neoplasm, H. Emb. Rh. number 1, transplanted in rats.
CPEB1 mediates hepatocellular carcinoma cancer stemness and chemoresistance.
CREB targets define the gene expression signature of malignancies having reduced levels of the tumor suppressor tristetraprolin.
Crimean-Congo hemorrhagic fever virus-encoded ovarian tumor (OTU) protease activity is dispensable for virus RNA polymerase function.
Critical role of tristetraprolin and AU-rich element RNA-binding protein 1 in the suppression of cancer cell growth by globular adiponectin.
Cryptotanshinone, a novel tumor angiogenesis inhibitor, destabilizes tumor necrosis factor-? mRNA via decreasing nuclear-cytoplasmic translocation of RNA-binding protein HuR.
Crystal structure of the human heterogeneous ribonucleoprotein A18 RNA-recognition motif.
CSDE1 controls gene expression through the miRNA-mediated decay machinery.
CX-5461-loaded nucleolus-targeting nanoplatform for cancer therapy through induction of pro-death autophagy.
Cytokine gene expression in rejecting and tolerant rat lung allograft models: analysis by RT-PCR.
Cytokine gene expression in skin and lymphoid organs in graft versus host disease.
DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression.
Design and Construction of Aroyl-Hydrazone Derivatives: Synthesis, Crystal Structure, Molecular Docking and Their Biological Activities.
Design, synthesis and anticancer activity of fluorocyclopentenyl-purines and - pyrimidines.
Detection of hepatitis C virus NS5 protein and genome in Chinese carcinoma of the extrahepatic bile duct and its significance.
Differential expression of PIWIL2 in papillary thyroid cancers.
Differential expression of the TFIIIB subunits Brf1 and Brf2 in cancer cells.
Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function.
Direct Regulation of Alternative Splicing by SMAD3 through PCBP1 Is Essential to the Tumor-Promoting Role of TGF-?.
Distinct roles for the RNA-binding protein Staufen1 in prostate cancer.
DNA dependent RNA polymerase from Ehrlich ascites tumor cells. II. Factors stimulating the activity of RNA polymerase II.
DNA dependent RNA polymerase from ehrlich ascites tumor cells. IV. A novel protein repressing RNA polymerase II.
DNA dependent RNA polymerase from Ehrlich ascites tumor cells. V. Characterization of a factor repressing RNA polymerase II as a ribonucleoprotein.
DNA methylation in the promoter of ribosomal RNA genes in human cells as determined by genomic sequencing.
DNA-dependent RNA polymerase from Ehrlich ascites tumor cells. I. Partial purification and characterization of RNA polymerase II.
DNA-dependent RNA polymerases of Ehrlich carcinoma, other murine ascites tumors, and murine normal tissues.
DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs.
Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase.
Downregulation of Msi1 suppresses the growth of human colon cancer by targeting p21cip1.
Downregulation of tumor suppressor QKI in gastric cancer and its implication in cancer prognosis.
Dysregulated transcription across diverse cancer types reveals the importance of RNA-binding protein in carcinogenesis.
Dysregulation of the basal RNA polymerase transcription apparatus in cancer.
EBF1-Mediated Upregulation of Ribosome Assembly Factor PNO1 Contributes to Cancer Progression by Negatively Regulating the p53 Signaling Pathway.
Editorial retraction. Down-regulation of human telomerase reverse transcriptase through anti-c-myc siRNA in human colon cancer Colo 320 cells.
Effect of all-trans-retinoic acid on nuclear RNA polymerase activity in chemically-induced rat mammary tumors.
Effect of cis-diamminedichloroplatinum(II) and other platinum compounds on the RNA polymerase reaction.
Effect of RNA tumor virus-specific protein p30 on reverse transcriptase. Intraspecies and interspecies interaction between reverse transcriptase and p30.
Effect of sex hormones on RNA synthesis of androgen-dependent mouse mammary tumor (Shionogi carcinoma).
Effect of tumour growth on hepatic neutral ribonuclease and its inhibitor and on RNA polymerase activity of liver nuclei.
Elevated dengue virus nonstructural protein 1 serum levels and altered toll-like receptor 4 expression, nitric oxide, and tumor necrosis factor alpha production in dengue hemorrhagic Fever patients.
Elevated FUS/TLS expression is negatively associated with E-cadherin expression and prognosis of patients with non-small cell lung cancer.
Elevated Heterogeneous Nuclear Ribonucleoprotein C Expression Correlates With Poor Prognosis in Patients With Surgically Resected Lung Adenocarcinoma.
Elevated Hu-Antigen Receptor (HuR) Expression is Associated with Tumor Aggressiveness and Poor Prognosis but not with COX-2 Expression in Invasive Breast Carcinoma Patients.
Elevated tRNA(iMet) synthesis can drive cell proliferation and oncogenic transformation.
Emerging roles of RNA and RNA-binding protein network in cancer cells.
Enhanced RNA polymerase III-dependent transcription is required for oncogenic transformation.
Enzyme-linked immunosorbent assay for p16(INK4a) - a new triage test for the detection of cervical intraepithelial neoplasia?
Epigenetic inactivation of the splicing RNA-binding protein CELF2 in human breast cancer.
Estrogen-dependent in vitro stimulation of RNA synthesis in hormone-dependent mammary tumors of the rat.
ETMR: a tumor entity in its infancy.
ETV6/RUNX1 transcript is a target of RNA-binding protein IGF2BP1 in t(12;21)(p13;q22)-positive acute lymphoblastic leukemia.
Eukaryotic initiation Factor 4AIII facilitates hepatocellular carcinoma cell proliferation, migration, and epithelial-mesenchymal transition process via antagonistically binding to WD repeat domain 66 with miRNA-2113.
EWS represses cofilin 1 expression by inducing nuclear retention of cofilin 1 mRNA.
EWSR1 and ATF1 rearrangements in clear cell odontogenic carcinoma: presentation of a case.
Exploring a common mechanism of alcohol-induced deregulation of RNA Pol III genes in liver and breast cells.
Exploring the Allosteric Territory of Protein Function.
Exploring the molecular basis of RNA recognition by the dimeric RNA-binding protein via molecular simulation methods.
Expression of a truncated form of the c-Kit tyrosine kinase receptor and activation of Src kinase in human prostatic cancer.
Expression of cold-inducible RNA-binding protein (CIRP) in pituitary adenoma and its relationships with tumor recurrence.
Expression of insulin-like growth factor II mRNA-binding protein 3 predicts early recurrence and poor prognosis in intrahepatic cholangiocarcinoma.
Expression of La Ribonucleoprotein Domain Family Member 4B (LARP4B) in Liver Cancer and Their Clinical and Prognostic Significance.
Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumors.
Expression of the neural RNA-binding protein Musashi1 in human gliomas.
Expression of the Neural RNA-binding protein Musashi1 in pediatric brain tumors.
Expression of the oncofetal protein IGF2BP3 in endometrial clear cell carcinoma: assessment of frequency and significance.
Expression of the RNA-binding protein CRD-BP in brain and non-small cell lung tumors.
Expression of the RNA-binding protein VICKZ in normal hematopoietic tissues and neoplasms.
Expression polymerase chain reaction: a sensitive method for analysis of gene expression in human tumours.
Expression profile, clinical significance, and biological function of insulin-like growth factor 2 messenger RNA-binding proteins in non-small cell lung cancer.
Expression, Intracellular Localization, and Prognostic Value of Plasminogen Activator Inhibitor 1 and PAI-1 RNA-Binding Protein 1 in Primary and Recurrent Ovarian Cancer: A Study of the Tumor Bank Ovarian Cancer Network.
Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis.
Extrapulmonary small cell carcinomas express K homology domain containing protein overexpressed in cancer, but carcinoid tumors do not.
FXR1 expression domain in Wilms tumor.
G3BP1 and G3BP2 regulate translation of interferon-stimulated genes: IFITM1, IFITM2 and IFITM3 in the cancer cell line MCF7.
Gender Specific Differences in RNA Polymerase III Transcription.
Gene expression of erythropoietin in hepatocellular carcinoma.
Gene expression of mutant erythropoietin in hepatocellular carcinoma.
Gene-editing by CRISPR-Cas9 in combination with anthracycline therapy via tumor microenvironment-switchable, EGFR-targeted, and nucleus-directed nanoparticles for head and neck cancer suppression.
Genes Associated with Calcium Signaling are Involved in Alcohol-Induced Breast Cancer Growth.
Genetic Mapping with Multiple Levels of Phenotypic Information Reveals Determinants of Lymphocyte Glucocorticoid Sensitivity.
Genomic analyses of the RNA-binding protein Hu antigen R (HuR) identify a complex network of target genes and novel characteristics of its binding sites.
Genomic characterization of a novel dsRNA virus detected in the phytopathogenic fungus Verticillium dahliae Kleb.
GPRC5A is a potential oncogene in pancreatic ductal adenocarcinoma cells that is upregulated by gemcitabine with help from HuR.
Growth complementation of influenza virus temperature-sensitive mutants in mouse cells which express the RNA polymerase and nucleoprotein genes.
Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR.
Hepatic Premalignant Alterations Triggered by Human Nephrotoxin Aristolochic Acid I in Canines.
Hepatitis C virus induces E6AP-dependent degradation of the retinoblastoma protein.
Hepatitis C virus nonstructural protein 5A inhibits tumor necrosis factor-alpha-mediated apoptosis in Huh7 cells.
Hepatitis C virus nonstructural protein NS4B transforms NIH3T3 cells in cooperation with the Ha-ras oncogene.
Heterogeneous nuclear ribonucleoprotein A2/B1 is a negative regulator of human breast cancer metastasis by maintaining the balance of multiple genes and pathways.
Heterogeneous nuclear ribonucleoprotein B1 expression in malignant mesothelioma.
High expression of cytoplasmic polyadenylation element-binding protein 4 correlates with poor prognosis of patients with colorectal cancer.
High expression of interleukin-enhancer binding factor 3 predicts poor prognosis in patients with lung adenocarcinoma.
High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma.
High expression of spermatogenesis associated serine rich 2 promotes tumorigenicity in esophageal squamous cell carcinoma cells and is associated with poor patient prognosis.
High expression of the RNA-binding protein RBPMS2 in gastrointestinal stromal tumors.
High LIN28A Expressing Ovarian Cancer Cells Secrete Exosomes That Induce Invasion and Migration in HEK293 Cells.
High-grade neuroendocrine carcinomas of the lung express K homology domain containing protein overexpressed in cancer but carcinoid tumors do not.
hnRNP K suppresses apoptosis independent of p53 status by maintaining high levels of endogenous caspase inhibitors.
HNRNPH1 is required for rhabdomyosarcoma cell growth and survival.
hnRNPK-regulated LINC00263 promotes malignant phenotypes through miR-147a/CAPN2.
How Ribosomes Translate Cancer.
Hu antigen R (HuR) heterogeneous expression quantification as a prognostic marker of melanoma.
Human Antigen R Binding and Regulation of SOX2 mRNA in Human Mesenchymal Stem Cells.
Human La Protein: An RNA-Binding Protein Involved in Ovarian Cancer Development and Multidrug Resistance.
Human oncoprotein Musashi-2 N-terminal RNA recognition motif backbone assignment and identification of RNA-binding pocket.
Human RNA polymerase II-associated factor complex: dysregulation in cancer.
Human somatic cell mutagenesis creates genetically tractable sarcomas.
HuR and the bioenergetic signature of breast cancer: a low tumor expression of the RNA-binding protein predicts a higher risk of disease recurrence.
HuR is a post-transcriptional regulator of core metabolic enzymes in pancreatic cancer.
HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis.
HuR posttranscriptionally regulates WEE1: implications for the DNA damage response in pancreatic cancer cells.
HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A.
HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis.
HuR-targeted nanotherapy in combination with AMD3100 suppresses CXCR4 expression, cell growth, migration and invasion in lung cancer.
HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells.
HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis.
Identification of a novel splice variant of the human musashi-1 gene.
Identification of novel human tumor cell-specific CaMK-II variants.
Identification of RNA-binding protein LARP4B as a tumor suppressor in glioma.
IGF2BP1: a novel binding protein of p38 MAPK.
IGF2BP3 (IMP3) expression in angiosarcoma, epithelioid hemangioendothelioma, and benign vascular lesions.
IGF2BP3 facilitates cell proliferation and tumorigenesis via modulation of JAK/STAT signalling pathway in human bladder cancer.
Immunohistochemical Analysis Revealed a Correlation between Musashi-2 and Cyclin-D1 Expression in Patients with Oral Squamous Cells Carcinoma.
IMP3 RNP Safe Houses Prevent miRNA-Directed HMGA2 mRNA Decay in Cancer and Development.
Implication of RNA-binding protein La in proliferation, migration and invasion of lymph node-metastasized hypopharyngeal SCC cells.
IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer.
In vitro transcription of wound tumor virus RNA by virion-associated RNA transcriptase.
Increased expression of insulin-like growth factor-II messenger RNA-binding protein 1 is associated with tumor progression in patients with lung cancer.
Increased mediator complex subunit 15 expression is associated with poor prognosis in hepatocellular carcinoma.
Increased TIA-1 gene expression in the tumor microenvironment after locoregional administration of tumor necrosis factor-alpha to patients with soft tissue limb sarcoma.
Inhibition of BET proteins impairs estrogen-mediated growth and transcription in breast cancers by pausing RNA polymerase advancement.
Inhibition of intrahepatic gamma interferon production by hepatitis C virus nonstructural protein 5A in transgenic mice.
Inhibition of mammalian and oncornavirus nucleic acid polymerase activities by alkoxybenzophenanthridine alkaloids.
Inhibition of nuclear DNA-dependent RNA polymerases from mouse ascites tumors and liver by glycerol.
Inhibition of ribonucleases by ribonucleotides and transition state analogs in cell-free extracts from Ehrlich ascites tumor cells.
Inhibition of RNA polymerase III transcription by Triptolide attenuates colorectal tumorigenesis.
Insights from HuR biology point to potential improvement for second-line ovarian cancer therapy.
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) promotes lung tumorigenesis via attenuating p53 stability.
Insulin-like growth factor II messenger RNA-binding protein 3 expression in gastrointestinal mesenchymal tumors.
Insulin-like Growth Factor II Messenger RNA-binding Protein 3 in Salivary Gland Tumors.
Insulin-Like Growth Factor II mRNA-Binding Protein 3 Expression Correlates with Poor Prognosis in Acral Lentiginous Melanoma.
Insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor formation and invasion and predicts poor prognosis in oral squamous cell carcinoma.
Insulin-like growth factor II-messenger RNA-binding protein-3 and lung cancer.
Integrative genomic analyses of the RNA-binding protein, RNPC1, and its potential role in cancer prediction.
Interaction of the hepatitis B virus X protein with the lysine methyltransferase SET and MYND domain-containing 3 induces activator protein 1 activation.
Intracellular functions of RNA-binding protein, Musashi1, in stem and cancer cells.
Intratumoral anti-HuD immunotoxin therapy for small cell lung cancer and neuroblastoma.
Invasive growth associated with Cold-Inducible RNA-Binding Protein expression drives recurrence of surgically resected brain metastases.
Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts.
Knockdown of MSI1 inhibited the cell proliferation of human osteosarcoma cells by targeting p21 and p27.
L523S, an RNA-binding protein as a potential therapeutic target for lung cancer.
La protein contributes to cells proliferation and migration and serves as a potential therapeutic target for hepatocellular carcinoma.
Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks.
LARP1 isoform expression in human cancer cell lines.
Leptin, Adiponectin, and Sam68 in Bone Metastasis from Breast Cancer.
Lin28 induces epithelial-to-mesenchymal transition and stemness via downregulation of let-7a in breast cancer cells.
LIN28 Is Selectively Expressed by Primordial and Pre-Meiotic Germ Cells in the Human Fetal Ovary.
Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain.
Lin28A enhances chemosensitivity of colon cancer cells to 5-FU by promoting apoptosis in a let-7 independent manner.
LIN28A Modulates Splicing and Gene Expression Programs in Breast Cancer Cells.
LIN28B enhanced tumorigenesis in an autochthonous KRAS
LIN28B promotes the progression of colon cancer by increasing B-cell lymphoma 2 expression.
LINC00680 and TTN-AS1 Stabilized by EIF4A3 Promoted Malignant Biological Behaviors of Glioblastoma Cells.
LncRNA SNHG1 and RNA binding protein hnRNPL form a complex and coregulate CDH1 to boost the growth and metastasis of prostate cancer.
Long non-coding RNA DBH-AS1 promotes cancer progression in diffuse large B-cell lymphoma by targeting FN1 via RNA-binding protein BUD13.
Long noncoding RNA SOX2OT promotes the proliferation of pancreatic cancer by binding to FUS.
Loss of RNA-Binding Protein RBMS1 Promotes a Metastatic Transcriptional Program in Colorectal Cancer.
Loss of TARBP2 Drives the Progression of Hepatocellular Carcinoma via miR-145-SERPINE1 Axis.
Lower expression of LINC00092 in lung adenocarcinoma might mean poorer prognosis: A study based on data mining and bioinformatics.
Mammary tumor induction in transgenic mice expressing an RNA-binding protein.
Mapping the Transcriptome-Wide Landscape of RBP Binding Sites Using gPAR-CLIP-seq: Bioinformatic Analysis.
Marek's Disease Virus (Gallid alphaherpesvirus 2)-Encoded miR-M2-5p Simultaneously Promotes Cell Proliferation and Suppresses Apoptosis Through RBM24 and MYOD1-Mediated Signaling Pathways.
MBNL2 Regulates DNA Damage Response via Stabilizing p21.
MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M.
Mechanisms of transcriptional regulation by WT1 (Wilms' tumour 1).
Merkel cell carcinoma expresses K homology domain-containing protein overexpressed in cancer similar to other high-grade neuroendocrine carcinomas.
Merkel Cell Polyomavirus Small T Antigen Is Oncogenic in Transgenic Mice.
Merlin, a tumor suppressor, interacts with transactivation-responsive RNA-binding protein and inhibits its oncogenic activity.
Methylcholanthrene induced murine primitive neuroectodermal tumor: ultrastructure and nuclear RNA polymerase activity.
MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence.
microRNA-18a induces apoptosis in colon cancer cells via the autophagolysosomal degradation of oncogenic heterogeneous nuclear ribonucleoprotein A1.
Mild hypothermia facilitates the expression of cold-inducible RNA-binding protein and heat shock protein 70.1 in mouse brain.
Mining Database for the Clinical Significance and Prognostic Value of ESRP1 in Cutaneous Malignant Melanoma.
miR-181b functions as an oncomiR in colorectal cancer by targeting PDCD4.
miR-200/375 control epithelial plasticity-associated alternative splicing by repressing the RNA-binding protein Quaking.
MiR-4282 inhibits tumor progression through down-regulation of ZBTB2 by targeting LIN28B in oral squamous cell carcinoma.
miR-519 suppresses tumor growth by reducing HuR levels.
Molecular analysis of malignant triton tumors.
Molecular detection of microscopic and submicroscopic deletions associated with Miller-Dieker syndrome.
Molecular pathways: rodent parvoviruses--mechanisms of oncolysis and prospects for clinical cancer treatment.
Morphoregulatory functions of the RNA-binding motif protein 3 in cell spreading, polarity and migration.
Mouse DNA polymerase accompanied by a novel RNA polymerase activity: purification and partial characterization.
Msi1 promotes tumor growth and cell proliferation by targeting cell cycle checkpoint proteins p21, p27 and p53 in cervical carcinomas.
Msi1 promotes tumor progression by epithelial-to-mesenchymal transition in cervical cancer.
MSI2-TGF-?/TGF-? R1/SMAD3 positive feedback regulation in glioblastoma.
Multi-omics analysis of tumor mutation burden combined with immune infiltrates in melanoma.
Multilevel prioritization of gene regulators associated with consensus molecular subtypes of colorectal cancer.
Multiple functions of HuR in urinary tumors.
Multiple Functions of the RNA-Binding Protein HuR in Cancer Progression, Treatment Responses and Prognosis.
Multiple Mechanisms Inactivate the LIN-41 RNA-Binding Protein To Ensure a Robust Oocyte-to-Embryo Transition in Caenorhabditis elegans.
Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation.
Musashi 2 contributes to the stemness and chemoresistance of liver cancer stem cells via LIN28A activation.
Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer.
Musashi-1-A Stemness RBP for Cancer Therapy?
Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC).
Musashi-2 is a prognostic marker for the survival of patients with cervical cancer.
Musashi-2, a novel oncoprotein promoting cervical cancer cell growth and invasion, is negatively regulated by p53-induced miR-143 and miR-107 activation.
Musashi1 enhances chemotherapy resistance of pediatric glioblastoma cells in vitro.
Musashi1 Impacts Radio-Resistance in Glioblastoma by Controlling DNA-Protein Kinase Catalytic Subunit.
Musashi1, an evolutionarily conserved neural RNA-binding protein, is a versatile marker of human glioma cells in determining their cellular origin, malignancy, and proliferative activity.
Muscone derivative ZM-32 inhibits breast tumor angiogenesis by suppressing HuR-mediated VEGF and MMP9 expression.
NEDDylation in liver cancer: The regulation of the RNA binding protein Hu antigen R.
NF-?B2/p52:c-Myc:hnRNPA1 Pathway Regulates Expression of Androgen Receptor Splice Variants and Enzalutamide Sensitivity in Prostate Cancer.
No Matter How You Splice It, RBM39 Inhibition Targets Spliceosome Mutant AML.
Nonstructural protein 5B promotes degradation of the NORE1A tumor suppressor to facilitate hepatitis C virus replication.
Novel polypyridyl ruthenium complexes acting as high affinity DNA intercalators, potent transcription inhibitors and antitumor reagents.
Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation.
Nuclear factor 90 promotes angiogenesis by regulating HIF-1?/VEGF-A expression through the PI3K/Akt signaling pathway in human cervical cancer.
Nucleic acids from subcellular fractions of N-nitrosodiethylamine-induced hepatoma in mice.
On the border of the amyloidogenic sequences: prefix analysis of the parallel beta sheets in the PDB_Amyloid collection.
Ovarian tumor cell detection in peripheral blood progenitor cells harvests by RT-PCR.
Overexpression of miR-20a promotes the progression of osteosarcoma by directly targeting QKI2.
Overexpression of RNA-binding protein CELF1 prevents apoptosis and destabilizes pro-apoptotic mRNAs in oral cancer cells.
p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB.
Paraneoplastic Scleroderma: Are There Any Clues?
Partial purification and characterization of RNA polymerase from nuclei of Ehrlich ascites tumor cells.
Pathogenic mechanisms and the potential clinical value of circFoxo3 in cancers.
Phase II study of TAS-106 in patients with platinum-failure recurrent or metastatic head and neck cancer and nasopharyngeal cancer.
Phenylglyoxal as a template site-specific reagent for DNA and RNA polymerases. Selective inhibition of initiation.
Phosphorylation of OGFOD1 by Cell Cycle-Dependent Kinase 7/9 Enhances the Transcriptional Activity of RNA Polymerase II in Breast Cancer Cells.
Phosphorylation of the activation loop of gamma p21-activated kinase (gamma-Pak) and related kinases (MSTs) in normal and stressed neutrophils.
PNO1 regulates autophagy and apoptosis of hepatocellular carcinoma via the MAPK signaling pathway.
Porcine transmissible gastroenteritis virus nonstructural protein 2 contributes to inflammation via NF-?B activation.
Posttranscriptional gene expression regulation in CpG-activated macrophages depends on FXR1P RNA-binding protein.
Posttranscriptional regulation of cancer traits by HuR.
Potency of a Scalable Nanoparticulate Subunit Vaccine.
Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics.
Potential Role of Musashi-2 RNA-Binding Protein in Cancer EMT.
pp32r1 controls the decay of the RNA-binding protein HuR.
Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias.
Prediction of RBP binding sites on circRNAs using an LSTM-based deep sequence learning architecture.
Prognostic alternative splicing regulatory network of RBM25 in hepatocellular carcinoma.
Prognostic role and biologic features of Musashi-2 expression in colon polyps and during colorectal cancer progression.
Prognostic value of Musashi-1 in endometrioid adenocarcinoma.
Programmed cell death 4 protein (Pdcd4) and homeodomain-interacting protein kinase 2 (Hipk2) antagonistically control translation of Hipk2 mRNA.
Prolyl isomerase Pin1 in cancer.
Protein arginine methylation of SERBP1 by protein arginine methyltransferase 1 affects cytoplasmic/nuclear distribution.
Proteomics-Based Characterization of miR-574-5p Decoy to CUGBP1 Suggests Specificity for mPGES-1 Regulation in Human Lung Cancer Cells.
PTBP1 modulates osteosarcoma chemoresistance to cisplatin by regulating the expression of the copper transporter SLC31A1.
PUM1 represses CDKN1B translation and contributes to prostate cancer progression.
QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism.
QKI, a miR-200 target gene, suppresses epithelial-to-mesenchymal transition and tumor growth.
QKI-5 suppresses cyclin D1 expression and proliferation of oral squamous cell carcinoma cells via MAPK signalling pathway.
QKI5-mediated alternative splicing of the histone variant macroH2A1 regulates gastric carcinogenesis.
Quaking and miR-155 interactions in inflammation and leukemogenesis.
Quaking orchestrates a post-transcriptional regulatory network of endothelial cell cycle progression critical to angiogenesis and metastasis.
RBM10, a New Regulator of p53.
RBM5 as a putative tumor suppressor gene for lung cancer.
Re: Yves Allorya, Willemien Beukers, Ana Sagrera, et al. Telomerase Reverse Transcriptase Promoter Mutations in Bladder Cancer: High Frequency Across Stages, Detection in Urine, and Lack of Association with Outcome. Eur Urol 2014;65:360-6: Telomerase Expression and Stem Cells: Urologic Epithelial Perspective.
Reaction of biological thiols with the tumor inhibitor jatrophone. Inhibition of RNA polymerase.
Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes.
Regulation of ELL2 stability and polyubiquitination by EAF2 in prostate cancer cells.
Regulation of gene expression by the RNA-binding protein Sam68 in cancer.
Regulation of transcription by DNA-bound non-histone nuclear proteins.
Regulators and mediators of radiation-induced fibrosis: Gene expression profiles and a rationale for Smad3 inhibition.
Replicase-based plasmid DNA shows anti-tumor activity.
Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma.
Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells.
Reverse transcriptase of RNA tumor viruses. V. In vitro proteolysis of reverse transcriptase from avian myeloblastosis virus and isolation of a polypeptide manifesting only RNase H activity.
RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1? signaling in nucleus pulposus cells.
RNA polymerase - an important molecular target of triptolide in cancer cells.
RNA polymerase activity in homotransplanted rat brain tumors initially induced by ethylnitrosourea.
RNA polymerase chain reaction detects different levels of four alternatively spliced WT1 transcripts in Wilms' tumors.
RNA Polymerase III Output Is Functionally Linked to tRNA Dimethyl-G26 Modification.
RNA tumor virus and reverse transcriptase. I. Biochemical studies on the ESP-1 particles. II. Role of the reverse transcriptase in murine RNA tumor virus.
RNA-binding protein (RBFOX1) inherited polymorphism rs8051518 is not associated with splice factor mutations in myelodysplastic syndromes and myeloproliferative neoplasms.
RNA-binding protein 39: a promising therapeutic target for cancer.
RNA-binding protein CELF1 enhances cell migration, invasion, and chemoresistance by targeting ETS2 in colorectal cancer.
RNA-binding protein CELF1 promotes tumor growth and alters gene expression in oral squamous cell carcinoma.
RNA-binding protein CELF6 is cell cycle regulated and controls cancer cell proliferation by stabilizing p21.
RNA-binding protein Dnd1 inhibits epithelial-mesenchymal transition and cancer stem cell-related traits on hepatocellular carcinoma cells.
RNA-binding protein HuR promotes bladder cancer progression by competitively binding to the long noncoding HOTAIR with miR-1.
RNA-Binding Protein HuR Regulates Both Mutant and Wild-Type IDH1 in IDH1-Mutated Cancer.
RNA-binding protein HuR sequesters microRNA-21 to prevent translation repression of proinflammatory tumor suppressor gene programmed cell death 4.
RNA-binding protein IMP-3 promotes cell survival via IGF-II signaling after ionizing radiation.
RNA-binding protein insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor invasion and predicts early recurrence and poor prognosis in hepatocellular carcinoma.
RNA-binding protein KHSRP promotes tumor growth and metastasis in non-small cell lung cancer.
RNA-Binding Protein L1TD1 Interacts with LIN28 via RNA and is Required for Human Embryonic Stem Cell Self-Renewal and Cancer Cell Proliferation.
RNA-Binding Protein La Mediates TGF?-Induced Epithelial to Mesenchymal Transition and Cancer Stem Cell Properties.
RNA-binding protein Lin28 in cancer and immunity.
RNA-binding protein LIN28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases.
RNA-binding protein LIN28 is a marker for testicular germ cell tumors.
RNA-binding protein LIN28 is a sensitive marker of ovarian primitive germ cell tumours.
RNA-binding protein LIN28 is a sensitive marker of pediatric yolk sac tumors.
RNA-binding protein MSI2 isoforms expression and regulation in progression of triple-negative breast cancer.
RNA-Binding Protein Musashi1 Is a Central Regulator of Adhesion Pathways in Glioblastoma.
RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC.
RNA-binding protein QKI regulates contact inhibition via Yes-associate protein in ccRCC.
RNA-binding protein QKI suppresses breast cancer via RASA1/MAPK signaling pathway.
RNA-binding protein RBM38 acts as a tumor suppressor in gastric cancer.
RNA-binding protein RBM6 acts as a tumor suppressor gene to inhibit the progression of hepatocellular carcinoma.
RNA-binding protein RBM6 as a tumor suppressor gene represses the growth and progression in laryngocarcinoma.
RNA-binding protein RNPC1: acting as a tumor suppressor in breast cancer.
RNA-binding protein SAMD4A inhibits breast tumor angiogenesis by modulating the balance of angiogenesis program.
RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells.
RNA-Binding Protein ZFP36L1 Suppresses Hypoxia and Cell-Cycle Signaling.
RNA-binding Protein, GADD45-alpha, p27(Kip1), p53 and Genotoxic Stress Response in Relation to Chemoresistance in Cancer.
RNA-dependent RNA polymerase, RdRP, a promising therapeutic target for cancer and potentially COVID-19.
Role of MicroRNA Let-7 in Modulating Multifactorial Aspect of Neurodegenerative Diseases: an Overview.
Role of protein-protein interactions in the antiapoptotic function of EWS-Fli-1.
Role of RNA-binding protein tristetraprolin in tumor necrosis factor-? mediated gene expression.
Role of the RNA-binding protein HuR in colon carcinogenesis.
Role of the RNA-binding protein La in cancer pathobiology.
Rotavirus-encoded nonstructural protein 1 modulates cellular apoptotic machinery by targeting tumor suppressor protein p53.
Rox8 promotes microRNA-dependent yki messenger RNA decay.
S1-1 nuclear domains: characterization and dynamics as a function of transcriptional activity.
Sam68 is Overexpressed in Epithelial Ovarian Cancer and Promotes Tumor Cell Proliferation.
Sam68 promotes aerobic glycolysis in colorectal cancer by regulating PKM2 alternative splicing.
Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis.
Semi-quantitative Detection of RNA-dependent RNA Polymerase Activity of Human Telomerase Reverse Transcriptase Protein.
Serological and viral genetic features of patients with COVID-19 in a selected German patient cohort-correlation with disease characteristics.
Several regions of p53 are involved in repression of RNA polymerase III transcription.
Simian virus 40 large tumor antigen: a "RNA binding protein"?
Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing.
Small Proline-Rich Protein 2A and 2D Are Regulated by the RBM38-p73 Axis and Associated with p73-Dependent Suppression of Chronic Inflammation.
Specific anti-gastric cancer effects of a recombinant plasmid expressing nonstructural protein 1 of parvovirus H1.
Specificity protein 1-dependent p53-mediated suppression of human manganese superoxide dismutase gene expression.
SRSF7 maintains its homeostasis through the expression of Split-ORFs and nuclear body assembly.
STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA.
Stimulation of Oct-4 activity by Ewing's sarcoma protein.
Stress-response protein RBM3 attenuates the stem-like properties of prostate cancer cells by interfering with CD44 variant splicing.
Structural basis of RNA polymerase III transcription initiation.
Structure-Function Based Molecular Relationships in Ewing's Sarcoma.
Study of the loosely bound non-histone chromatin proteins. Stimulation of deoxyribonucleic acid-templated ribonucleic acid synthesis by a specific deoxyribonucleic acid-binding phosphoprotein fraction.
Sturcture-activity relationship of daunorubicin and its peptide derivatives.
SUMOylation modulates the LIN28A-let-7 signaling pathway in response to cellular stresses in cancer cells.
Suppressed humoral immunity is associated with dengue nonstructural protein NS1-elicited anti-death receptor antibody fractions in mice.
Suppression of PTBP1 signaling is responsible for mesenchymal stem cell induced invasion of low malignancy cancer cells.
Suramin inhibits tumor cell cytotoxicity mediated through natural killer cells, lymphokine-activated killer cells, monocytes, and tumor necrosis factor.
Synthesis and pharmacological studies of some (1,4)-naphthoquinono[3,2-c]-1H-pyrazoles, 2-substituted amino-1,4-naphthoquinones, and related compounds.
Synthesis of naphthalimide derivatives with potential anticancer activity, their comparative ds- and G-quadruplex-DNA binding studies and related biological activities.
Tamoxifen represses alcohol-induced transcription of RNA polymerase III-dependent genes in breast cancer cells.
TARBP2-mediated destabilization of Nanog overcomes sorafenib resistance in hepatocellular carcinoma.
Targeted proteomics driven verification of biomarker candidates associated with breast cancer aggressiveness.
Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.
Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis.
Telomerase and Telomere Length in Pulmonary Fibrosis.
Telomerase reverse transcriptase moonlights: Therapeutic targets beyond telomerase.
The Aberrant Expression of MicroRNA-125a-5p/IGF2BP3 Axis in Advanced Gastric Cancer and Its Clinical Relevance.
The clinical importance of a transcription reverse-transcription concerted (TRC) diagnosis using peritoneal lavage fluids in gastric cancer with clinical serosal invasion: a prospective, multicenter study.
The Expression of Insulin-Like Growth Factor 2 Messenger RNA-Binding Protein 3 in Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma.
The function of the RNA-binding protein hnRNP in cancer metastasis.
The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II.
The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells.
The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma.
The interaction of lncRNA EZR-AS1 with SMYD3 maintains overexpression of EZR in ESCC cells.
The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits.
The non-reverse transcriptase activity of the human telomerase reverse transcriptase promotes tumor progression (review).
The Oncofetal Protein IMP3: A Novel Molecular Marker to Predict Aggressive Meningioma.
The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer.
The oncogenic RNA-binding protein Musashi1 is regulated by tumor suppressor miRNAs.
The parafibromin tumor suppressor protein is part of a human Paf1 complex.
The Prognostic Value of Epithelial Membrane Protein 1 (EMP-1) in Patients with Laryngeal Carcinoma.
The Rbm38-p63 feedback loop is critical for tumor suppression and longevity.
The RNA polymerase III repressor MAF1 is regulated by ubiquitin-dependent proteasome degradation and modulates cancer drug resistance and apoptosis.
The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing.
The RNA-binding protein CUG-BP1 increases survivin expression in oesophageal cancer cells through enhanced mRNA stability.
The RNA-binding protein CUGBP1 regulates stability of tumor necrosis factor mRNA in muscle cells: implications for myotonic dystrophy.
The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression.
The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming.
The RNA-binding protein ESRP1 promotes human colorectal cancer progression.
The RNA-binding protein hnRNPA2 regulates ?-catenin protein expression and is overexpressed in prostate cancer.
The RNA-Binding Protein HuR in Digestive System Tumors.
The RNA-binding protein HuR inhibits expression of CCL5 and limits recruitment of macrophages into tumors.
The RNA-binding protein LARP4 regulates cancer cell migration and invasion.
The RNA-binding protein MEX3B mediates resistance to cancer immunotherapy by downregulating HLA-A expression.
The RNA-Binding Protein PCBP1 Functions as a Tumor Suppressor in Prostate Cancer by Inhibiting Mitogen Activated Protein Kinase 1.
The RNA-binding protein Sam68 is a multifunctional player in human cancer.
The RNA-binding protein Sam68 regulates tumor cell viability and hepatic carcinogenesis by inhibiting the transcriptional activity of FOXOs.
The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation.
The RNA-binding protein SORBS2 suppresses hepatocellular carcinoma tumourigenesis and metastasis by stabilizing RORA mRNA.
The role of RNA-binding protein tristetraprolin in cancer and immunity.
The roles of hnRNP A2/B1 in RNA biology and disease.
The stability and oncogenic function of LIN28A are regulated by USP28.
The Staufen1-dependent cell cycle regulon or how a misregulated RNA-binding protein leads to cancer.
The stem cell-specific protein TRIM71 inhibits maturation and activity of the pro-differentiation miRNA let-7 via two independent molecular mechanisms.
The superoxide dismutase 1 3'UTR maintains high expression of the SOD1 gene in cancer cells: The involvement of the RNA-binding protein AUF-1.
The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4.
The Toll like receptor 4 ligand cold-inducible RNA-binding protein as vaccination platform against cancer.
The tumor suppressing effects of QKI-5 in prostate cancer: a novel diagnostic and prognostic protein.
The tumor suppressor parafibromin is required for posttranscriptional processing of histone mRNA.
The tumor suppressor, parafibromin, mediates histone H3 K9 methylation for cyclin D1 repression.
The tumour suppressor brain tumour (Brat) regulates linker histone dBigH1 expression in the Drosophila female germline and the early embryo.
Therapeutic targeting of circ-CUX1/EWSR1/MAZ axis inhibits glycolysis and neuroblastoma progression.
Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog.
Topoisomerase II? promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation.
Transcription factor TAFII250 phosphorylates the acidic domain of Mdm2 through recruitment of protein kinase CK2.
Transcriptional repression of Myc underlies the tumour suppressor function of AGO1 in Drosophila.
Transcriptionally active RNA polymerases from Morris hepatomas and rat liver. Elucidation of the mechanism for the preferential increase in the tumour RNA polymerase I.
Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling.
Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression.
Transcriptomic studies provide insights into the tumor suppressive role of miR-146a-5p in non-small cell lung cancer (NSCLC) cells.
Transgenic overexpression of the oncofetal RNA binding protein KOC leads to remodeling of the exocrine pancreas.
Translational Control of TOP2A Influences Doxorubicin Efficacy.
Trisubstituted Pyrrolinones as Small-Molecule Inhibitors Disrupting the Protein-RNA Interaction of LIN28 and Let-7.
Tumor necrosis factor and transforming growth factor ? regulate clock genes by controlling the expression of the cold inducible RNA-binding protein (CIRBP).
Tumor Suppressing Properties of Rodent Parvovirus NS1 Proteins and Their Derivatives.
Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells.
Tumor-targeted Nanoparticle Delivery of HuR siRNA Inhibits Lung Tumor Growth In Vitro and In Vivo By Disrupting the Oncogenic Activity of the RNA-binding Protein HuR.
UHM-ULM interactions in the RBM39-U2AF65 splicing-factor complex.
Uncovering the role of hnRNP K, an RNA-binding protein, in B-cell lymphomas.
Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells.
Utility of immobilon-bound phosphoproteins as substrates for protein phosphatases from neutrophils.
von Hippel-Lindau tumor suppressor gene-dependent mRNA stabilization of the survival factor parathyroid hormone-related protein in human renal cell carcinoma by the RNA-binding protein HuR.
WT1 and kidney progenitor cells.
ZFP36 Binds With PRC1 to Inhibit Tumor Growth and Increase 5-Fu Chemosensitivity of Hepatocellular Carcinoma.
Zika Virus as Oncolytic Therapy for Brain Cancer: Myth or Reality?
Zinc finger RNA-binding protein promotes non-small-cell carcinoma growth and tumor metastasis by targeting the Notch signaling pathway.
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program.
[Detection of tumor load in chronic myeloid leukemia during treatment with transplantation by conventional cytogenetics, nested-RT-PCR and FISH]
[Primary neuroectodermal tumor (PNET) of the kidney: 26 cases. Current status of its diagnosis and treatment]
[RNA-dependent RNA polymerase in tumor cells]
Neoplasms, Germ Cell and Embryonal
DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs.
LIN28 Is Selectively Expressed by Primordial and Pre-Meiotic Germ Cells in the Human Fetal Ovary.
RNA-binding protein LIN28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases.
RNA-binding protein LIN28 is a marker for testicular germ cell tumors.
RNA-binding protein LIN28 is a sensitive marker of ovarian primitive germ cell tumours.
Neoplasms, Neuroepithelial
Spinal cord astroblastoma with EWSR1-BEND2 fusion classified as HGNET-MN1 by methylation classification: a case report.
Neoplasms, Squamous Cell
L523S, an RNA-binding protein as a potential therapeutic target for lung cancer.
Nephritis
Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis.
Nervous System Diseases
A Live-Attenuated Zika Virus Vaccine with High Production Capacity Confers Effective Protection in Neonatal Mice.
CELF4 regulates translation and local abundance of a vast set of mRNAs, including genes associated with regulation of synaptic function.
Neuralgia
Intranasal delivery of an antisense oligonucleotide to the RNA-binding protein HuR relieves nerve injury-induced neuropathic pain.
Neuroblastoma
Activity of a 40 kDa RNA-binding protein correlates with MYCN and c-fos mRNA stability in human neuroblastoma.
Antiapoptotic but not antiviral function of human bcl-2 assists establishment of Japanese encephalitis virus persistence in cultured cells.
Application of Serum ELAVL4 (HuD) Antigen Assay for Small Cell Lung Cancer Diagnosis.
Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein.
Effect of low doses of actinomycin D on neuroblastoma cell lines.
Genomic organization and isoform-specific tissue expression of human NAPOR (CUGBP2) as a candidate gene for familial arrhythmogenic right ventricular dysplasia.
HuD, a neuronal-specific RNA-binding protein, is a potential regulator of MYCN expression in human neuroblastoma cells.
Intratumoral anti-HuD immunotoxin therapy for small cell lung cancer and neuroblastoma.
Isolation and expression of Napor/CUG-BP2 in embryo development.
NDM29, a RNA polymerase III-dependent non coding RNA, promotes amyloidogenic processing of APP and amyloid ? secretion.
Overexpression of tissue-nonspecific alkaline phosphatase increases the expression of neurogenic differentiation markers in the human SH-SY5Y neuroblastoma cell line.
Post-transcriptional regulation of HSP70 expression following oxidative stress in SH-SY5Y cells: the potential involvement of the RNA-binding protein HuR.
Region-specific alternative splicing in the nervous system: implications for regulation by the RNA-binding protein NAPOR.
RNA-binding protein RBM3 prevents NO-induced apoptosis in human neuroblastoma cells by modulating p38 signaling and miR-143.
The inhibition of 45A ncRNA expression reduces tumor formation, affecting tumor nodules compactness and metastatic potential in neuroblastoma cells.
Neurodegenerative Diseases
A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons.
Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity, and cognitive behavior through altered Sortilin splicing.
Activity-dependent FUS dysregulation disrupts synaptic homeostasis.
ALS/FTLD-Linked Mutations in FUS Glycine Residues Cause Accelerated Gelation and Reduced Interactions with Wild-Type FUS.
Amyloid-Forming Segment Induces Aggregation of FUS-LC Domain from Phase Separation Modulated by Site-Specific Phosphorylation.
An Amyloid-Like Pathological Conformation of TDP-43 Is Stabilized by Hypercooperative Hydrogen Bonds.
An optimized InCell Western screening technique identifies hexachlorophene as a novel potent TDP43 targeting drug.
Ataxin-2 Is Droppin' Some Knowledge.
Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38
Biomolecular condensation of the microtubule-associated protein tau.
Conserved role for Ataxin-2 in mediating endoplasmic reticulum dynamics.
Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1.
DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation.
Depletion of TDP-43 decreases fibril and plaque ?-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model.
Detection of TAR DNA-binding protein 43 (TDP-43) oligomers as initial intermediate species during aggregate formation.
Differential toxicity of TAR DNA-binding protein 43 isoforms depends on their submitochondrial localization in neuronal cells.
Dysfunctional RNA-binding protein biology and neurodegeneration in experimental autoimmune encephalomyelitis in female mice.
Elevated FUS/TLS expression is negatively associated with E-cadherin expression and prognosis of patients with non-small cell lung cancer.
Exploring the Interaction of
Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching.
FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention.
FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2.
FUS is sequestered in nuclear aggregates in ALS patient fibroblasts.
FUS Regulates Activity of MicroRNA-Mediated Gene Silencing.
Genetic Perturbation of TIA1 Reveals a Physiological Role in Fear Memory.
HuD regulates SOD1 expression during oxidative stress in differentiated neuroblastoma cells and sporadic ALS motor cortex.
Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function.
Mapping the Transcriptome-Wide Landscape of RBP Binding Sites Using gPAR-CLIP-seq: Bioinformatic Analysis.
Mechanisms of TDP-43 Proteinopathy Onset and Propagation.
Mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex.
Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity.
Molecular structure and interactions within amyloid-like fibrils formed by a low-complexity protein sequence from FUS.
Motor neuron expression of the voltage-gated calcium channel cacophony restores locomotion defects in a Drosophila, TDP-43 loss of function model of ALS.
Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms.
Neurotoxic effects of TDP-43 overexpression in C. elegans.
Pleiotropic requirements for human TDP-43 in the regulation of cell and organelle homeostasis.
PRO-MINE: A Bioinformatics Repository and Analytical Tool for TARDBP Mutations.
PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons.
Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II.
Restoration of motor defects caused by loss of Drosophila TDP-43 by expression of the voltage-gated calcium channel, Cacophony, in central neurons.
RNA-binding proteins in neurodegeneration: mechanisms in aggregate.
Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.
Severe respiratory changes at end stage in a FUS-induced disease state in adult rats.
Similar dose-dependence of motor neuron cell death caused by wild type human TDP-43 and mutants with ALS-associated amino acid substitutions.
Six GU-rich (6GUR) FUS-binding motifs detected by normalization of CLIP-seq by Nascent-seq.
Staufen 1 amplifies proapoptotic activation of the unfolded protein response.
Structural basis for RNA recognition by the N-terminal tandem RRM domains of human RBM45.
Structural Transition, Function and Dysfunction of TDP-43 in Neurodegenerative Diseases.
TDP-43 dysfunction restricts dendritic complexity by inhibiting CREB activation and altering gene expression.
TDP-43 enhances translation of specific mRNAs linked to neurodegenerative disease.
TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity.
TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets.
TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration.
The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation.
The Impact of ALS-Associated Genes hnRNPA1, MATR3, VCP and UBQLN2 on the Severity of TDP-43 Aggregation.
The multi-functional RNA-binding protein G3BP1 and its potential implication in neurodegenerative disease.
The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD.
Tristetraprolin destabilizes NOX2 mRNA and protects dopaminergic neurons from oxidative damage in Parkinson's disease.
Neuroectodermal Tumors
A renal cell carcinoma with EWSR1-TFE3 fusion gene.
Neuroectodermal Tumors, Primitive
Methylcholanthrene induced murine primitive neuroectodermal tumor: ultrastructure and nuclear RNA polymerase activity.
Murine primitive neuroectodermal tumor: nucleolar isolation and RNA polymerase inhibition.
Neuroendocrine Tumors
Expression of glucose transporter-1 is correlated with hypoxia-inducible factor 1? and malignant potential in pancreatic neuroendocrine tumors.
Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27Kip1 levels and poor prognosis.
Neurofibrosarcoma
HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis.
Neuroinflammatory Diseases
A novel target to reduce microglial inflammation and neuronal damage after deep hypothermic circulatory arrest.
Cold-inducible RNA-binding protein is an important mediator of alcohol-induced brain inflammation.
Cold-inducible RNA-binding protein mediates neuroinflammation in cerebral ischemia.
RNA-Binding Protein HuR Promotes Th17 Cell Differentiation and Can Be Targeted to Reduce Autoimmune Neuroinflammation.
Targeting Neurological Manifestations of Coronaviruses by Candidate Phytochemicals: A Mechanistic Approach.
Targeting the RNA-Binding Protein HuR Alleviates Neuroinflammation in Experimental Autoimmune Encephalomyelitis: Potential Therapy for Multiple Sclerosis.
The Potential Contribution of Dysfunctional RNA-Binding Proteins to the Pathogenesis of Neurodegeneration in Multiple Sclerosis and Relevant Models.
The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells.
The Value of Extracellular Cold-Inducible RNA-Binding Protein (eCIRP) in Predicting the Severity and Prognosis of Patients After Cardiac Arrest: A Preliminary Observational Study.
Neurologic Manifestations
Detection of human immunodeficiency virus type 2 in brain tissue.
Neuromuscular Diseases
Myo-granules Connect Physiology and Pathophysiology.
Systematic analysis of cis-elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cells.
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.
Newcastle Disease
Comparison of RNA polymerase associated with Newcastle disease virus and a temperature-sensitive mutant of Newcastle disease virus isolated from persistently infected L cells.
Generation of recombinant lentogenic Newcastle disease virus from cDNA.
Genomic Diversity and Evolution of Quasispecies in Newcastle Disease Virus Infections.
Immunogenicity of a truncated enterovirus 71 VP1 protein fused to a Newcastle disease virus nucleocapsid protein fragment in mice.
Immunogenicity of Newcastle disease virus vectors expressing Norwalk virus capsid protein in the presence or absence of VP2 protein.
Mechanisms and consequences of Newcastle disease virus W protein subcellular localization in the nucleus or mitochondria.
Methylation of messenger RNA of Newcastle disease virus in vitro by a virion-associated enzyme.
Polyadenylation-dependent screening assay for respiratory syncytial virus RNA transcriptase activity and identification of an inhibitor.
Presence of genomic polyadenylate and absence of detectable virion transcriptase in human coronavirus OC-43.
Recombinant Newcastle Disease virus capsids displaying enterovirus 71 VP1 fragment induce a strong immune response in rabbits.
Rescue of recombinant Newcastle disease virus: current cloning strategies and RNA polymerase provision systems.
RNA-dependent RNA polymerase gene analysis of worldwide Newcastle disease virus isolates representing different virulence types and their phylogenetic relationship with other members of the paramyxoviridae.
Studies on the structural basis of the RNA polymerase activity of newcastle disease virus particles.
Non-alcoholic Fatty Liver Disease
SIRT1 mediates the role of RNA-binding protein QKI 5 in the synthesis of triglycerides in non-alcoholic fatty liver disease mice via the PPAR?/FoxO1 signaling pathway.
Obesity
RNA-binding protein PTB and microRNA-221 coregulate AdipoR1 translation and adiponectin signaling.
Ocular Hypertension
Software for Quantifying and Batch Processing Images of Brn3a and RBPMS Immunolabelled Retinal Ganglion Cells in Retinal Wholemounts.
Oligodendroglioma
Somatostatin receptor 2A protein expression characterizes anaplastic oligodendrogliomas with favorable outcome.
Opsoclonus-Myoclonus Syndrome
High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma.
Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability.
Orthomyxoviridae Infections
A Naturally Occurring Deletion in the Effector Domain of H5N1 Swine Influenza Virus Nonstructural Protein 1 Regulates Viral Fitness and Host Innate Immunity.
Emerging antiviral drugs.
Reassortant Eurasian Avian-Like Influenza A(H1N1) Virus from a Severely Ill Child, Hunan Province, China, 2015.
Osteoarthritis
RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family.
Osteoarthritis, Knee
Synovial fluid concentrations of cold-inducible RNA-binding protein are associated with severity in knee osteoarthritis.
Osteoporosis
Case Report: Severe Osteoporosis and Preventive Therapy in RNA Polymerase III-Related Leukodystrophy.
Motor coordination defects in mice deficient for the Sam68 RNA-binding protein.
Osteosarcoma
Circular RNA LARP4 correlates with decreased Enneking stage, better histological response, and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging microRNA-424 in osteosarcoma.
Effects of mutation in hepatitis C virus nonstructural protein 5A on interferon resistance mediated by inhibition of PKR kinase activity in mammalian cells.
Retargeting Polyomavirus-Like Particles to Cancer Cells by Chemical Modification of Capsid Surface.
RNA-binding protein PUM2 suppresses osteosarcoma progression via partly and competitively binding to STARD13 3'UTR with miRNAs.
The association of inhibitor of Growth 4 with its prognostic value in osteogenic sarcoma.
Ovarian Neoplasms
Expression, Intracellular Localization, and Prognostic Value of Plasminogen Activator Inhibitor 1 and PAI-1 RNA-Binding Protein 1 in Primary and Recurrent Ovarian Cancer: A Study of the Tumor Bank Ovarian Cancer Network.
High RBM3 expression in prostate cancer independently predicts a reduced risk of biochemical recurrence and disease progression.
Human La Protein: An RNA-Binding Protein Involved in Ovarian Cancer Development and Multidrug Resistance.
Inhibition of RNA-Binding Protein Musashi-1 Suppresses Malignant Properties and Reverses Paclitaxel Resistance in Ovarian Carcinoma.
lncRNA-PRLB Confers Paclitaxel Resistance of Ovarian Cancer Cells by Regulating RSF1/NF-?B Signaling Pathway.
miR-1224-5p inhibits the proliferation and invasion of ovarian cancer via targeting SND1.
Ovarian tumor cell detection in peripheral blood progenitor cells harvests by RT-PCR.
Regulation of hnRNPA1 by microRNAs controls the miR-18a-K-RAS axis in chemotherapy-resistant ovarian cancer.
RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells.
The RNA-Binding Protein CELF2 Inhibits Ovarian Cancer Progression by Stabilizing FAM198B.
The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer.
[Construction of TRAIL gene eukaryotic expression vector modulated by hTERT gene core promoter and its effect on apoptosis of ovarian cancer cells.]
Pancreatic Cyst
Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA.
Pancreatic Neoplasms
An RNA-binding protein, Hu-antigen R, in pancreatic cancer epithelial to mesenchymal transition, metastasis, and cancer stem cells.
Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer.
KIF20A-mediated RNA granule transport system promotes the invasiveness of pancreatic cancer cells.
RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer.
Use of IMP3 in identification of carcinoma in fine needle aspiration biopsies of pancreas.
pancreatic ribonuclease deficiency
Tiny abortive initiation transcripts exert antitermination activity on an RNA hairpin-dependent intrinsic terminator.
Pancreatitis
Extracellular cold-inducible RNA-binding protein regulates neutrophil extracellular trap formation and tissue damage in acute pancreatitis.
Increased admission serum cold-inducible RNA-binding protein concentration is associated with prognosis of severe acute pancreatitis.
Pancreatitis, Acute Necrotizing
Birnavirus VP1 proteins form a distinct subgroup of RNA-dependent RNA polymerases lacking a GDD motif.
Comparison of the RNA polymerase genes of marine birnavirus strains and other birnaviruses.
In vitro RNA synthesis by infectious pancreatic necrosis virus-associated RNA polymerase.
Incomplete dsRNA genomes in purified infectious pancreatic necrosis virus.
IPNV VP5, a novel anti-apoptosis gene of the Bcl-2 family, regulates Mcl-1 and viral protein expression.
Mapping the site of guanylylation on VP1, the protein primer for infectious pancreatic necrosis virus RNA synthesis.
Protein-primed RNA synthesis in vitro by the virion-associated RNA polymerase of infectious pancreatic necrosis virus.
Sequence analysis of infectious pancreatic necrosis virus genome segment B and its encoded VP1 protein: a putative RNA-dependent RNA polymerase lacking the Gly-Asp-Asp motif.
The N-terminus of the RNA polymerase from infectious pancreatic necrosis virus is the determinant of genome attachment.
VP3, a structural protein of infectious pancreatic necrosis virus, interacts with RNA-dependent RNA polymerase VP1 and with double-stranded RNA.
Papilloma
Emerging antiviral drugs.
Oral Papillomas Associated With Felis catus Papillomavirus Type 1 in 2 Domestic Cats.
The binding of RNA polymerase to polyoma and papilloma DNA.
Tumor regression is associated with a specific immune response to the E2 protein of cottontail rabbit papillomavirus.
Papillomavirus Infections
Approved Antiviral Drugs over the Past 50 Years.
Paralysis
Analysis of the RdRp, intergenic and structural polyprotein regions, and the complete genome sequence of Kashmir bee virus from infected honeybees (Apis mellifera) in Korea.
CsrA and TnaB Coregulate Tryptophanase Activity To Promote Exotoxin-Induced Killing of Caenorhabditis elegansby Enteropathogenic Escherichia coli.
Phylogenetic analysis of the RNA-Dependent RNA polymerase (RdRp) and a predicted structural protein (pSP) of the chronic bee paralysis virus (CBPV) isolated from various geographic regions.
Severe acute respiratory syndrome coronavirus protein nsp1 is a novel eukaryotic translation inhibitor that represses multiple steps of translation initiation.
The first complete genome sequence of an iflavirus from the endoparasitoid wasp Tetrastichus brontispae.
The use of RNA-dependent RNA polymerase for the taxonomic assignment of Picorna-like viruses (order Picornavirales) infecting Apis mellifera L. populations.
Paramyxoviridae Infections
Analysis of Paramyxovirus Transcription and Replication by High-Throughput Sequencing.
Analysis of the mutations in the active site of the RNA-dependent RNA polymerase of human parainfluenza virus type 3 (HPIV3).
Human parainfluenza virus type 2 L protein regions required for interaction with other viral proteins and mRNA capping.
Human parainfluenza virus type 3 phosphoprotein: identification of serine 333 as the major site for PKC zeta phosphorylation.
Identification of two essential aspartates for polymerase activity in parainfluenza virus L protein by a minireplicon system expressing secretory luciferase.
Phosphoprotein, P of human parainfluenza virus type 3 prevents self-association of RNA-dependent RNA polymerase, L.
Regions on the hemagglutinin-neuraminidase proteins of human parainfluenza virus type-1 and Sendai virus important for membrane fusion.
RNA polymerase activity in virions of parainfluenza 1 virus (Sendai).
Role of a highly conserved NH(2)-terminal domain of the human parainfluenza virus type 3 RNA polymerase.
Specific interaction in vitro and in vivo of glyceraldehyde-3-phosphate dehydrogenase and LA protein with cis-acting RNAs of human parainfluenza virus type 3.
Sumoylation of the P protein at K254 plays an important role in growth of parainfluenza virus 5 (PIV5).
The switch between acute and persistent paramyxovirus infection caused by single amino acid substitutions in the RNA polymerase P subunit.
Two regions of the P protein are required to be active with the L protein for human parainfluenza virus type 1 RNA polymerase activity.
Paraneoplastic Syndromes
ANOVA, a putative astrocytic RNA-binding protein gene that maps to chromosome 19q13.3.
Paraneoplastic Syndromes, Nervous System
Autoantibodies against the Hel-N1 RNA-binding protein among patients with lung carcinoma: an association with type I anti-neuronal nuclear antibodies.
Parathyroid Neoplasms
Loss of expression for the Wnt pathway components adenomatous polyposis coli and glycogen synthase kinase 3-beta in parathyroid carcinomas.
The tumor suppressor, parafibromin, mediates histone H3 K9 methylation for cyclin D1 repression.
Parkinson Disease
Association between the neuron-specific RNA-binding protein ELAVL4 and Parkinson disease.
Spen modulates lipid droplet content in adult Drosophila glial cells and protects against paraquat toxicity.
Targeted Quantification of Detergent-Insoluble RNA-Binding Proteins in Human Brain Reveals Stage and Disease Specific Co-aggregation in Alzheimer's Disease.
Tristetraprolin destabilizes NOX2 mRNA and protects dopaminergic neurons from oxidative damage in Parkinson's disease.
Parkinsonian Disorders
Ectopic expression of Musashi-1 in Alzheimer disease and Pick disease.
Investigating FUS variation in Parkinson's disease.
Parvoviridae Infections
A putative nucleoside triphosphate-binding domain in the nonstructural protein of B19 parvovirus is required for cytotoxicity.
IgG response to the immunoreactive region of parvovirus B19 nonstructural protein by immunoblot assay with a recombinant antigen.
Porcine Parvovirus Infection Causes Pig Placenta Tissue Damage Involving Nonstructural Protein 1 (NS1)-Induced Intrinsic ROS/Mitochondria-Mediated Apoptosis.
Pemphigoid, Bullous
Bullous pemphigoid sera that contain antibodies to BPAg2 also contain antibodies to LABD97 that recognize epitopes distal to the NC16A domain.
Interaction of BP180 (type XVII collagen) and alpha6 integrin is necessary for stabilization of hemidesmosome structure.
Serological studies in bullous pemphigoid: a literature review of antibody titers at presentation and in clinical remission.
Pemphigus
The CD40/CD40 ligand system is involved in the pathogenesis of pemphigus.
Periodontitis
Draft genome sequence of Fusobacterium nucleatum ChDC F128, isolated from a periodontitis lesion.
The induced RNA-binding protein, HuR, targets 3'-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis.
Persistent Infection
A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis.
Antigenic and genetic variation in cytopathic hepatitis A virus variants arising during persistent infection: evidence for genetic recombination.
Assembly of viroplasms by viral nonstructural protein Pns9 is essential for persistent infection of rice gall dwarf virus in its insect vector.
Borrelia burgdorferi erpT expression in the arthropod vector and murine host.
Coxsackievirus B3 replication and persistence in intestinal cells from mice infected orally and in the human CaCo-2 cell line.
Expression of the aphthovirus RNA polymerase gene in Escherichia coli and its use together with other bioengineered nonstructural antigens in detection of late persistent infections.
Insights into structural dynamics of allosteric binding sites in HCV RNA-dependent RNA polymerase.
Intrahost Selection Pressure Drives Equine Arteritis Virus Evolution during Persistent Infection in the Stallion Reproductive Tract.
Prevalence of antibodies to human parvovirus B19 nonstructural protein in persons with various clinical outcomes following B19 infection.
Restricted viral RNA synthesis in establishment of persistent infection in Vero cells with a Sendai virus mutant.
Systemic Expression of a Viral RdRP Protects Against Retrovirus Infection and Disease.
Phlebotomus Fever
Insights into the Evolutionary Origin of Mediterranean Sandfly Fever Viruses.
Picornaviridae Infections
Highlights in the development of new antiviral agents.
Pituitary Neoplasms
Expression of cold-inducible RNA-binding protein (CIRP) in pituitary adenoma and its relationships with tumor recurrence.
Plague
Evidence for the involvement of influenza A (fowl plague Rostock) virus protein P2 in ApG and mRNA primed in vitro RNA synthesis.
Evolutionary selection of biofilm-mediated extended phenotypes in Yersinia pestis in response to a fluctuating environment.
[Inhibitory effect of alpha-methyl-1-adamantane methylamine hydrochloride (rimantadine) on RNA-dependent RNA polymerase induction in culture of cells, infected with influenza virus]
Plasmacytoma
Transcription termination and chromatin structure of the active immunoglobulin kappa gene locus.
Pneumonia
Acetylcysteine for the Treatment of Suspected Remdesivir-Associated Acute Liver Failure in COVID-19: A Case Series.
Cold-inducible RNA-binding protein might determine the severity and the presences of major/minor criteria for severe community-acquired pneumonia and best predicted mortality.
Crystallization and preliminary X-ray diffraction studies of a surface mutant of the middle domain of PB2 from human influenza A (H1N1) virus.
Molecular mechanisms of respiratory syncytial virus replication: a guide for the development of antivirals.
Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection.
Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12.
Poliomyelitis
Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase.
Nucleotide variation in Sabin type 3 poliovirus from an Albanian infant with agammaglobulinemia and vaccine associated poliomyelitis.
Poliovirus RNA synthesis in vitro: structural elements and antibody inhibition.
StralSV: assessment of sequence variability within similar 3D structures and application to polio RNA-dependent RNA polymerase.
Studies on the attenuation phenotype of polio vaccines: poliovirus RNA polymerase derived from Sabin type 1 sequence is temperature sensitive in the uridylylation of VPg.
Polymyositis
Anti-synthetase syndrome: a new autoantibody to phenylalanyl transfer RNA synthetase (anti-Zo) associated with polymyositis and interstitial pneumonia.
Coexistence of anti-Jo1 and anti-signal recognition particle antibodies in a polymyositis patient.
The long-term outcome of interstitial lung disease with anti-aminoacyl-tRNA synthetase antibodies.
Porcine Reproductive and Respiratory Syndrome
A Nanobody Targeting Viral Nonstructural Protein 9 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication.
Amino acid at position 176 was essential for porcine reproductive and respiratory syndrome virus (PRRSV) non-structural protein 1? (nsp1?) as an inhibitor to the induction of IFN-?.
Amino acid residues Ala283 and His421 in the RNA-dependent RNA polymerase of porcine reproductive and respiratory syndrome virus play important roles in viral ribavirin sensitivity and quasispecies diversity.
B Cell Tetramer Development for Veterinary Vaccinology.
Cellular poly(c) binding proteins 1 and 2 interact with porcine reproductive and respiratory syndrome virus nonstructural protein 1? and support viral replication.
Characterization and utility of phages bearing peptides with affinity to porcine reproductive and respiratory syndrome virus nsp7 protein.
Cold-inducible RNA-binding protein (CIRBP) promotes porcine reproductive and respiratory syndrome virus (PRRSV)-induced inflammatory response.
Complex assembly, crystallization and preliminary X-ray crystallographic studies of the swine major histocompatibility complex molecule SLA-1*1502.
Critical role of cytochrome c1 and its cleavage in porcine reproductive and respiratory syndrome virus nonstructural protein 4-induced cell apoptosis via interaction with nsp4.
Development of Monoclonal Antibodies Specifically Recognizing the Nonstructural Protein 12 of Type 2 Porcine Reproductive and Respiratory Syndrome Virus.
Differential host cell gene expression and regulation of cell cycle progression by nonstructural protein 11 of porcine reproductive and respiratory syndrome virus.
Effective suppression of replication of porcine reproductive and respiratory syndrome virus by adenovirus-mediated small interfering RNAs targeting ORF1b, 5 and 7 genes.
Efficient -2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein.
Galectin-3 inhibits replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp12 in vitro.
Identification of a novel linear B-cell epitope in nonstructural protein 11 of porcine reproductive and respiratory syndrome virus that are conserved in both genotypes.
Identification of an Intramolecular Switch That Controls the Interaction of Helicase nsp10 with Membrane-Associated nsp12 of Porcine Reproductive and Respiratory Syndrome Virus.
Identification of epitopes on nonstructural protein 7 of porcine reproductive and respiratory syndrome virus recognized by monoclonal antibodies using phage-display technology.
Identification of Nonstructural Protein 8 as the N-Terminus of the RNA-Dependent RNA Polymerase of Porcine Reproductive and Respiratory Syndrome Virus.
Identification of Porcine Reproductive and Respiratory Syndrome Virus ORF1a-Encoded Nonstructural Proteins in Virus-Infected Cells.
Identification of the strain-specifically truncated nonstructural protein 10 of porcine reproductive and respiratory syndrome virus in infected cells.
Identification of three site mutations in nonstructural protein 1?, glycoprotein 3 and glycoprotein 5 that correlate with increased interferon ? resistance of porcine reproductive and respiratory syndrome virus.
Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: nsp1 function as interferon antagonist.
Interaction of cellular poly(C)-binding protein 2 with nonstructural protein 1? is beneficial to Chinese highly pathogenic porcine reproductive and respiratory syndrome virus replication.
Interleukin-1? expression by a recombinant porcine reproductive and respiratory syndrome virus.
Involvement of PRRSV NSP3 and NSP5 in the autophagy process.
Mapping the nonstructural protein interaction network of porcine reproductive and respiratory syndrome virus.
Mutagenesis analysis of porcine reproductive and respiratory syndrome virus nonstructural protein 7.
Mutations in a Highly Conserved Motif of nsp1? Protein Attenuate the Innate Immune Suppression Function of Porcine Reproductive and Respiratory Syndrome Virus.
Nonstructural protein 11 (nsp11) of porcine reproductive and respiratory syndrome virus (PRRSV) promotes PRRSV infection in MARC-145 cells.
Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus Suppresses Both MAVS and RIG-I Expression as One of the Mechanisms to Antagonize Type I Interferon Production.
Nonstructural protein 1? subunit-based inhibition of NF-?B activation and suppression of interferon-? production by porcine reproductive and respiratory syndrome virus.
Nonstructural protein 9 residues 586 and 592 are critical sites in determining the replication efficiency and fatal virulence of the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus.
Nuclear export signal of PRRSV NSP1? is necessary for type I IFN inhibition.
ORF1a of highly pathogenic PRRS attenuated vaccine virus plays a key role in neutralizing antibody induction in piglets and virus neutralization in vitro.
Porcine reproductive and respiratory syndrome virus expressing E2 of classical swine fever virus protects pigs from a lethal challenge of highly-pathogenic PRRSV and CSFV.
Porcine Reproductive and Respiratory Syndrome Virus Infection Induces both eIF2? Phosphorylation-Dependent and -Independent Host Translation Shutoff.
Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 1 Beta Interacts with Nucleoporin 62 To Promote Viral Replication and Immune Evasion.
Porcine reproductive and respiratory syndrome virus nonstructural protein 1beta modulates host innate immune response by antagonizing IRF3 activation.
Programmed -2/-1 Ribosomal Frameshifting in Simarteriviruses: an Evolutionarily Conserved Mechanism.
Proteasomal degradation of nonstructural protein 12 by RNF114 suppresses porcine reproductive and respiratory syndrome virus replication.
Proteolytic processing of the porcine reproductive and respiratory syndrome virus replicase.
PRR5, 7 and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis.
Suppression of immune responses in pigs by nonstructural protein 1 of Porcine reproductive and respiratory syndrome virus.
The DEAD-box RNA helicase 5 positively regulates the replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp9 in vitro.
The Endoribonuclease Activity Essential for the Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus to Inhibit NLRP3 Inflammasome-Mediated IL-1? Induction.
The interaction between host Annexin A2 and viral Nsp9 is beneficial for replication of porcine reproductive and respiratory syndrome virus.
The interaction of nonstructural protein 9 with retinoblastoma protein benefits the replication of genotype 2 porcine reproductive and respiratory syndrome virus in vitro.
The Nonstructural Protein 1 Papain-Like Cysteine Protease Was Necessary for Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 1 to Inhibit Interferon-? Induction.
The nonstructural protein 11 of porcine reproductive and respiratory syndrome virus induces STAT2 degradation to inhibit interferon signaling.
The nonstructural protein 11 of porcine reproductive and respiratory syndrome virus inhibits NF-?B signaling by means of its deubiquitinating activity.
The Nsp12-coding region of type 2 PRRSV is required for viral subgenomic mRNA synthesis.
The Nucleocapsid Protein and Nonstructural Protein 10 of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Enhance CD83 Production via NF-?B and Sp1 Signaling Pathways.
Poxviridae Infections
Emerging antiviral drugs.
Pre-Eclampsia
Lin28B/miR-92b Promote the Proliferation, Migration, and Invasion in the Pathogenesis of Preeclampsia via the DKK1/Wnt/?-Catenin Pathway.
NRP1 and MMP9 are dual targets of RNA-binding protein QKI5 to alter VEGF-R/ NRP1 signalling in trophoblasts in preeclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
CDX2 gene expression in acute lymphoblastic leukemia.
ETV6/RUNX1 transcript is a target of RNA-binding protein IGF2BP1 in t(12;21)(p13;q22)-positive acute lymphoblastic leukemia.
False-Positive Nonstructural Protein 1 Antigen in a Patient with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Case Report with Literature Review.
The Role of Type I Insulin Like Growth Factor Receptor (IGF-IR) in Adult and Childhood Acute Lymphoblastic Leukemia.
[Effect of CDK Inhibitor LS-007 on Acute Lymphoblastic Leukemia and Its Mechanism].
Prostatic Neoplasms
Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68.
Distinct roles for the RNA-binding protein Staufen1 in prostate cancer.
Dysregulation of spliceosome gene expression in advanced prostate cancer by RNA-binding protein PSF.
Genotoxic stress causes the accumulation of the splicing regulator Sam68 in nuclear foci of transcriptionally active chromatin.
Identification of RNA-binding protein SNRPA1 for prognosis in prostate cancer.
Insulin-like growth factor-I receptor is suppressed through transcriptional repression and mRNA destabilization by a novel energy restriction-mimetic agent.
Molecular staging of prostate cancer. II. A comparison of the application of an enhanced reverse transcriptase polymerase chain reaction assay for prostate specific antigen versus prostate specific membrane antigen.
Molecular staging of prostate cancer. III. Effects of cystoscopy and needle biopsy on the enhanced reverse transcriptase polymerase chain reaction assay.
Prostate tumor cells infected with a recombinant influenza virus expressing a truncated NS1 protein activate cytolytic CD8+ cells to recognize noninfected tumor cells.
RNA-binding protein Musashi2 stabilizing androgen receptor drives prostate cancer progression.
Stress-response protein RBM3 attenuates the stem-like properties of prostate cancer cells by interfering with CD44 variant splicing.
The landscape of RNA polymerase II-associated chromatin interactions in prostate cancer.
The RNA-binding and adaptor protein Sam68 modulates signal-dependent splicing and transcriptional activity of the androgen receptor.
The RNA-binding protein FXR1 modulates prostate cancer progression by regulating FBXO4.
The RNA-binding protein hnRNPA2 regulates ?-catenin protein expression and is overexpressed in prostate cancer.
The RNA-binding protein HuR opposes the repression of ERBB-2 gene expression by microRNA miR-331-3p in prostate cancer cells.
The RNA-Binding Protein PCBP1 Functions as a Tumor Suppressor in Prostate Cancer by Inhibiting Mitogen Activated Protein Kinase 1.
The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells.
Proteinuria
Proteinuria and angiotensin converting enzyme (ACE) gene polymorphism.
Sub-chronic microcystin-LR renal toxicity in rats fed a high fat/high cholesterol diet.
Pseudorabies
A differential ELISA based on recombinant immunodominant epitopes of the gE gene of SHV-1 in a baculovirus-insect cell system to discriminate between pigs infected naturally with pseudorabies and vaccinated pigs.
Functional complementation of UL3.5-negative pseudorabies virus by the bovine herpesvirus 1 UL3.5 homolog.
In vitro stimulation of specific RNA polymerase II-mediated transcription by the pseudorabies virus immediate early protein.
Recombinant pseudorabies virus expressing P12A and 3C of FMDV can partially protect piglets against FMDV challenge.
Psoriasis
RT-PCR topography of chronic psoriasis skin based on analysis of T-cell receptor B variable region gene usage.
Suprabasal overexpression of the hsRPB7 gene in psoriatic epidermis as identified by a reverse transcriptase-polymerase chain reaction differential display model comparing psoriasis plaque tissue with peritonsillar mucosa.
Pulmonary Fibrosis
Extracellular CIRP Induces an Inflammatory Phenotype in Pulmonary Fibroblasts via TLR4.
Telomerase and Telomere Length in Pulmonary Fibrosis.
Rabies
A dual-functional priming-capping loop of rhabdoviral RNA polymerases directs terminal de novo initiation and capping intermediate formation.
A Dynein Light Chain 1 Binding Motif in Rabies Virus Polymerase L Protein Plays a Role in Microtubule Reorganization and Viral Primary Transcription.
An In Vitro RNA Synthesis Assay for Rabies Virus Defines Ribonucleoprotein Interactions Critical for Polymerase Activity.
An RNA polymerase activity in purified rabies virions.
Characterization of P gene-deficient rabies virus: propagation, pathogenicity and antigenicity.
Identification of a rabies virus T cell epitope on the basis of its similarity with a hepatitis B surface antigen peptide presented to T cells by the same MHC molecule (HLA-DPw4).
Identification of a region of the rabies virus N protein involved in direct binding to the viral RNA.
In silico structural elucidation of the rabies RNA-dependent RNA polymerase (RdRp) toward the identification of potential rabies virus inhibitors.
Mapping the interacting domains between the rabies virus polymerase and phosphoprotein.
Molecular docking studies with rabies virus glycoprotein to design viral therapeutics.
Molecular Function Analysis of Rabies Virus RNA Polymerase L Protein by Using an L Gene-Deficient Virus.
Nucleocytoplasmic shuttling of the rabies virus P protein requires a nuclear localization signal and a CRM1-dependent nuclear export signal.
Nucleotide and deduced amino acid sequences of the nominal nonstructural phosphoprotein of the ERA, PM and CVS-11 strains of rabies virus.
Phosphorylation of the N and M1 proteins of rabies virus.
Phylogenetic analysis of partial RNA-polymerase blocks II and III of Rabies virus isolated from the main rabies reservoirs in Brazil.
Polymerase activity of in vitro mutated rabies virus L protein.
Prokaryotic Expression, Purification, and Polyclonal Antibody Production of a Truncated Recombinant Rabies Virus L Protein.
Rabies virus M protein expressed in Escherichia coli and its regulatory role in virion-associated transcriptase activity.
Rabies virus P protein interacts with STAT1 and inhibits interferon signal transduction pathways.
Rabies: Presentation, case management and therapy.
Segmentation of the rabies virus genome.
Signature motifs of GDP polyribonucleotidyltransferase, a non-segmented negative strand RNA viral mRNA capping enzyme, domain in the L protein are required for covalent enzyme-pRNA intermediate formation.
Studies on rabies virus RNA polymerase: 1. cDNA cloning of the catalytic subunit (L protein) of avirulent HEP-flury strain and its expression in animal cells.
Studies on the rabies virus RNA polymerase: 2. Possible relationships between the two forms of the non-catalytic subunit (P protein).
Studies on the rabies virus RNA polymerase: 3. Two-dimensional electrophoretic analysis of the multiplicity of non-catalytic subunit (P protein).
The Mechanism and Clinical Outcome of patients with Corona Virus Disease 2019 Whose Nucleic Acid Test has changed from negative to positive, and the therapeutic efficacy of Favipiravir: A structured summary of a study protocol for a randomised controlled trial.
The specificity of rabies virus RNA encapsidation by nucleoprotein.
Transcriptase activity associated with rabies virion.
Vesicular Stomatitis Virus Phosphoprotein Dimerization Domain Is Dispensable for Virus Growth.
[Characterization of RdRp gene of rabies virus in China]
Raynaud Disease
Integrated Diagnosis Project for Inflammatory Myopathies: An association between autoantibodies and muscle pathology.
Sensitivity and specificity of anti-Jo-1 antibodies in autoimmune diseases with myositis.
Skeletal Muscle Involvement in Antisynthetase Syndrome.
[Antisynthetase myopathy].
Renal Insufficiency
Direct-acting antivirals for hepatitis C virus in patients on maintenance dialysis.
Renal Insufficiency, Chronic
Real-world safety and efficacy of sofosbuvir and ledipasvir for elderly patients.
Reoviridae Infections
Avian reovirus nonstructural protein microNS forms viroplasm-like inclusions and recruits protein sigmaNS to these structures.
Formation of the factory matrix is an important, though not a sufficient function of nonstructural protein mu NS during reovirus infection.
Protease cleavage of reovirus capsid protein mu1/mu1C is blocked by alkyl sulfate detergents, yielding a new type of infectious subvirion particle.
Reperfusion Injury
Blocking cold-inducible RNA-binding protein protects liver from ischemia-reperfusion injury.
Inhibition of a triggering receptor expressed on myeloid cells-1 (TREM-1) with an extracellular cold-inducible RNA-binding protein (eCIRP)-derived peptide protects mice from intestinal ischemia-reperfusion injury.
The Protective Effect of a Short Peptide Derived from Cold-Inducible Rna-Binding Protein in Renal Ischemia-Reperfusion Injury.
Respiratory Distress Syndrome
Deficiency in cold-inducible RNA-binding protein attenuates acute respiratory distress syndrome induced by intestinal ischemia-reperfusion.
Respiratory Insufficiency
A de novo c.1509dupA:p.R503fs mutation of FUS: report of a girl with sporadic juvenile amyotrophic lateral sclerosis.
Respiratory Syncytial Virus Infections
Approved Antiviral Drugs over the Past 50 Years.
Respiratory Tract Diseases
SARS-CoV-2 Infection and Antibody Response in a Symptomatic Cat from Italy with Intestinal B-Cell Lymphoma.
Respiratory Tract Infections
Randomised controlled trial for high-dose intravenous zinc as adjunctive therapy in SARS-CoV-2 (COVID-19) positive critically ill patients: trial protocol.
Seroepidemiology of human bocavirus in Hokkaido prefecture, Japan.
Reticuloendotheliosis, Avian
RNA polymerase activity in purified virions of avian reticuloendotheliosis viruses.
Retinoblastoma
A locking mechanism regulates RNA synthesis and host protein interaction by the hepatitis C virus polymerase.
Analysis of putative interactions between potyviral replication proteins and plant retinoblastoma proteins.
Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase.
Hepatitis C virus induces E6AP-dependent degradation of the retinoblastoma protein.
Retinoblastoma protein disrupts interactions required for RNA polymerase III transcription.
The interaction of nonstructural protein 9 with retinoblastoma protein benefits the replication of genotype 2 porcine reproductive and respiratory syndrome virus in vitro.
Retroviridae Infections
Systemic Expression of a Viral RdRP Protects Against Retrovirus Infection and Disease.
Reye Syndrome
The viral mechanism of Reye's syndrome.
Rhabdomyosarcoma
Distinct roles for the RNA-binding protein Staufen1 in prostate cancer.
Enhanced potency and efficacy of 29-mer shRNAs in inhibition of Enterovirus 71.
Rhabdomyosarcoma, Alveolar
Differential regulation of autophagy by STAU1 in alveolar rhabdomyosarcoma and non-transformed skeletal muscle cells.
Rheumatic Diseases
The Ro 60 kDa autoantigen comes into focus: interpreting epitope mapping experiments on the basis of structure.
The Ro 60 kDa autoantigen: insights into cellular function and role in autoimmunity.
Rhinitis
Homology Modeling and Analysis of Structure Predictions of the Bovine Rhinitis B Virus RNA Dependent RNA Polymerase (RdRp).
Rhinitis, Allergic
Theophylline inhibits the production of nitric oxide by peripheral blood mononuclear cells from patients with asthma.
Rift Valley Fever
A SAP30 complex inhibits IFN-beta expression in Rift Valley fever virus infected cells.
Generation and characterization of a recombinant Rift Valley fever virus expressing a V5 epitope-tagged RNA-dependent RNA polymerase.
Genetic evidence for an interferon-antagonistic function of rift valley fever virus nonstructural protein NSs.
Isolation and Identification of a Novel Phlebovirus, Hedi Virus, from Sandflies Collected in China.
Rift valley fever virus nonstructural protein NSs promotes viral RNA replication and transcription in a minigenome system.
RNA polymerase I-mediated expression of viral RNA for the rescue of infectious virulent and avirulent Rift Valley fever viruses.
Targeting TFIIH to inhibit host cell transcription by Rift Valley Fever Virus.
The C-terminal region of Rift Valley fever virus NSm protein targets the protein to the mitochondrial outer membrane and exerts antiapoptotic function.
The carboxy-terminal acidic domain of Rift Valley Fever virus NSs protein is essential for the formation of filamentous structures but not for the nuclear localization of the protein.
The nonstructural protein NSs induces a variable antibody response in domestic ruminants naturally infected with Rift Valley fever virus.
The Rift Valley fever virus nonstructural protein NSs is phosphorylated at serine residues located in casein kinase II consensus motifs in the carboxy-terminus.
The S segment of rift valley fever phlebovirus (Bunyaviridae) carries determinants for attenuation and virulence in mice.
Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH.
Rinderpest
A carboxy terminal domain of the L protein of rinderpest virus possesses RNA triphosphatase activity - The first enzyme in the viral mRNA capping pathway.
Complete genome sequence of transmissible gastroenteritis coronavirus PUR46-MAD clone and evolution of the purdue virus cluster.
Development of a reconstitution system for Rinderpest virus RNA synthesis in vitro.
Evidence for N? guanine methyl transferase activity encoded within the modular domain of RNA-dependent RNA polymerase L of a Morbillivirus.
Phosphoprotein P of Rinderpest virus binds to plus sense leader RNA: regulation by phosphorylation.
Rational attenuation of a morbillivirus by modulating the activity of the RNA-dependent RNA polymerase.
Rinderpest virus RNA polymerase subunits: mapping of mutual interacting domains on the large protein L and phosphoprotein p.
RNA trisphosphatase and guanylyl transferase activities are associated with the RNA polymerase protein L of Rinderpest virus.
The RNA triphosphatase domain of L protein of Rinderpest virus exhibits pyrophosphatase and tripolyphosphatase activities.
ring-type e3 ubiquitin transferase deficiency
Uncovering the Translational Regulatory Activity of the Tumor Suppressor BRCA1.
RNA Virus Infections
A promising antiviral candidate drug for the COVID-19 pandemic: A mini-review of remdesivir.
Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective.
RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic.
Staufen1 Protein Participates Positively in the Viral RNA Replication of Enterovirus 71.
The transcription factor FoxK participates with Nup98 to regulate antiviral gene expression.
rna-directed rna polymerase deficiency
Aminoacyl-Transfer RNA Synthetase Deficiency Promotes Angiogenesis via the Unfolded Protein Response Pathway.
In vitro transcriptase deficiency of temperature-dependent host range mutants of Chandipura virus.
Rotavirus Infections
MiR-525-3p mediates antiviral defense to rotavirus infection by targeting nonstructural protein 1.
Rotavirus infection induces the unfolded protein response of the cell and controls it through the nonstructural protein NSP3.
Rubella
Complementation of a deletion in the rubella virus p150 nonstructural protein by the viral capsid protein.
Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses.
Expression of the rubella virus nonstructural protein ORF and demonstration of proteolytic processing.
Identification of a Ca2+-binding domain in the rubella virus nonstructural protease.
Identification of the rubella virus nonstructural proteins.
Intracellular distribution of rubella virus nonstructural protein P150.
Live attenuated rubella viral vectors stably express HIV and SIV vaccine antigens while reaching high titers.
Mutational analysis of the rubella virus nonstructural polyprotein and its cleavage products in virus replication and RNA synthesis.
Mutations in the GDD motif of rubella virus putative RNA-dependent RNA polymerase affect virus replication.
Polymerase IV Plays a Crucial Role in Pollen Development in Capsella.
Proteolytic processing of rubella virus nonstructural proteins.
Rubella virus nonstructural protein 2 is a minor immunogen.
Rubella virus nonstructural protein protease domains involved in trans- and cis-cleavage activities.
Rubella virus RNA replication is cis-preferential and synthesis of negative- and positive-strand RNAs is regulated by the processing of nonstructural protein.
The Rubella Virus Capsid protein inhibits Mitochondrial Import.
Sarcoma
A cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy.
A de novo c.1509dupA:p.R503fs mutation of FUS: report of a girl with sporadic juvenile amyotrophic lateral sclerosis.
A renal cell carcinoma with EWSR1-TFE3 fusion gene.
A universal probe design for colorimetric detection of single-nucleotide variation with visible readout and high specificity.
Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.
ALS/FTLD-Linked Mutations in FUS Glycine Residues Cause Accelerated Gelation and Reduced Interactions with Wild-Type FUS.
Amyloid-Forming Segment Induces Aggregation of FUS-LC Domain from Phase Separation Modulated by Site-Specific Phosphorylation.
Autosomal dominant inheritance of rapidly progressive amyotrophic lateral sclerosis due to a truncation mutation in the fused in sarcoma (FUS) gene.
Binding of Escherichia coli RNA polymerase to a specific site located near the 3'-end of the avaian sarcoma virus genome.
Characteristic Features of FUS Inclusions in Spinal Motor Neurons of Sporadic Amyotrophic Lateral Sclerosis.
Characterization of RNA polymerases from Rous sarcoma virus-induced mouse ascites sarcoma cells.
CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability.
Development of a mouse monoclonal antibody for the detection of asymmetric dimethylarginine of Translocated in LipoSarcoma/FUsed in Sarcoma and its application in analyzing methylated TLS.
Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.
Functional characterization of a FUS mutant zebrafish line as a novel genetic model for ALS.
FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination.
FUS Regulates Activity of MicroRNA-Mediated Gene Silencing.
FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved introns.
FUS-mediated regulation of alternative RNA processing in neurons: insights from global transcriptome analysis.
Fused in sarcoma regulates DNA replication timing and kinetics.
Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11).
Fusion protein EWS-FLI1 is incorporated into a protein granule in cells.
HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis.
lncRNA DUXAP8 Facilitates Multiple Malignant Phenotypes and Resistance to PARP Inhibitor in HCC via Upregulating FOXM1.
Lysine acetylation regulates the RNA binding, subcellular localization and inclusion formation of FUS.
Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants.
Modulation of autophagy by miRNAs.
Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS.
Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms.
N-terminal acetylation modestly enhances phase separation and reduces aggregation of the low-complexity domain of RNA-binding protein fused in sarcoma.
Neuron-to-Neuron Transfer of FUS in Drosophila Primary Neuronal Culture Is Enhanced by ALS-Associated Mutations.
Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
Optineurin immunoreactivity in neuronal and glial intranuclear inclusions in adult-onset neuronal intranuclear inclusion disease.
Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity.
Pressure and Temperature Phase Diagram for Liquid-Liquid Phase Separation of the RNA-Binding Protein Fused in Sarcoma.
Reactive astrocytes secrete lcn2 to promote neuron death.
Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II.
Sequence Determines the Switch in the Fibril Forming Regions in the Low-Complexity FUS Protein and Its Variants.
Severe respiratory changes at end stage in a FUS-induced disease state in adult rats.
Specific aromatic foldamers potently inhibit spontaneous and seeded A?42 and A?43 fibril assembly.
Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains.
The Expression of Insulin-Like Growth Factor 2 Messenger RNA-Binding Protein 3 in Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma.
The Long Noncoding RNA RP11-728F11.4 Promotes Atherosclerosis.
The RNA-binding protein FUS is chaperoned and imported into the nucleus by a network of import receptors.
The RNA-binding Protein Fused in Sarcoma (FUS) Functions Downstream of Poly(ADP-ribose) Polymerase (PARP) in Response to DNA Damage.
Translocated in liposarcoma regulates the distribution and function of mammalian enabled, a modulator of actin dynamics.
Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency.
[Experimental study of hematopoietic cell gene expression profile induced by panax notoginosides in vitro]
[Molecular mechanisms of the biological effects of weak magnetic fields. V. Inactivation in vitro of recombinant Rous sarcoma virus reverse transcriptase under the combined action of weak direct and low-frequency alternating magnetic fields, adjusted to the cyclotron resonance of polar amino acid ions]
Sarcoma, Avian
An electron microscopic method for the mapping of proteins attached to nucleic acids.
Characterization of RNA polymerases from Rous sarcoma virus-induced mouse ascites sarcoma cells.
Identification of a transformation-specific protein induced by a Rous sarcoma virus.
Mode of inhibition of herpes simplex virus DNA polymerase by phosphonoacetate.
[Molecular mechanisms of the biological effects of weak magnetic fields. V. Inactivation in vitro of recombinant Rous sarcoma virus reverse transcriptase under the combined action of weak direct and low-frequency alternating magnetic fields, adjusted to the cyclotron resonance of polar amino acid ions]
[RNA-dependent RNA-polymerase in virions of Rous sarcoma virus]
Sarcoma, Clear Cell
A renal cell carcinoma with EWSR1-TFE3 fusion gene.
Sarcoma, Ewing
A trans-acting factor, isolated by the three-hybrid system, that influences alternative splicing of the amyloid precursor protein minigene.
An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation.
Analysis of the DNA-binding and transcriptional activation functions of human Fli-1 protein.
Characterization of a Family of RanBP2-Type Zinc Fingers that Can Recognize Single-Stranded RNA.
Cotranscriptional exon skipping in the genotoxic stress response.
Cutaneous syncytial myoepithelioma: A case report with emphasis on the differential diagnosis of problematic dermal tumors.
Cutting Edge: The RNA-Binding Protein Ewing Sarcoma Is a Novel Modulator of Lymphotoxin ? Receptor Signaling.
Cytomorphology and immunohistochemistry of a recurrent clear cell odontogenic carcinoma with molecular analysis: A case report with review of literature.
Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development.
EWS represses cofilin 1 expression by inducing nuclear retention of cofilin 1 mRNA.
EWSR1 and ATF1 rearrangements in clear cell odontogenic carcinoma: presentation of a case.
Exenteration and Custom Implant Brachytherapy as a Treatment for Recurrent Primary Extraskeletal Orbital Ewing Sarcoma.
Expression of the EWS/FLI-1 oncogene in murine primary bone-derived cells Results in EWS/FLI-1-dependent, ewing sarcoma-like tumors.
Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma.
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.
Fusion protein EWS-FLI1 is incorporated into a protein granule in cells.
HNRNPH1-dependent splicing of a fusion oncogene reveals a targetable RNA G-quadruplex interaction.
Identification of Ewing's sarcoma protein as a G-quadruplex DNA- and RNA-binding protein.
Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 is a Novel Post-Transcriptional Regulator of Ewing Sarcoma Malignancy.
Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis.
Nuclear Leukocyte Immunoglobulin-like Receptor A3 Is Monomeric and Is Involved in Multiple Layers of Regulated Gene Expression and Translation.
Pharmaceutical Interference of the EWS-FLI1-driven Transcriptome By Cotargeting H3K27ac and RNA Polymerase Activity in Ewing Sarcoma.
Spinal cord astroblastoma with EWSR1-BEND2 fusion classified as HGNET-MN1 by methylation classification: a case report.
Structure-Function Based Molecular Relationships in Ewing's Sarcoma.
Tyrosine kinase Pyk2 mediates G-protein-coupled receptor regulation of the Ewing sarcoma RNA-binding protein EWS.
Tyrosine Phosphorylation in the C-Terminal Nuclear Localization and Retention Signal (C-NLS) of the EWS Protein.
Sarcoma, Yoshida
The effect of dibromodulcitol on the template activity of DNA chromatin and nuclei from Yoshida sarcoma cells.
Scleroderma, Localized
RNA polymerase III-positive systemic sclerosis in a patient with circumscribed morphea.
Scleroderma, Systemic
Paraneoplastic Scleroderma: Are There Any Clues?
RNA polymerase III-positive systemic sclerosis in a patient with circumscribed morphea.
Scrapie
An antibiotic dependent conditional lethal mutant with a lesion affecting transcription and translation.
Seizures
Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice.
Absence of RNA-binding protein FXR2P prevents prolonged phase of kainate-induced seizures.
Alteration of RNA synthesis in vitro in intact cerebral cortex nuclei induced by convulsions in seizure-susceptible El mice.
Complex seizure disorder caused by Brunol4 deficiency in mice.
Etiology of a genetically complex seizure disorder in Celf4 mutant mice.
MDH2 is an RNA binding protein involved in downregulation of sodium channel Scn1a expression under seizure condition.
RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy.
Sepsis
A cold-inducible RNA-binding protein (CIRP)-derived peptide attenuates inflammation and organ injury in septic mice.
Abundance of the {delta} Subunit of RNA Polymerase Is Linked to the Virulence of Streptococcus agalactiae.
Blocking cold-inducible RNA-binding protein protects liver from ischemia-reperfusion injury.
Cirp Induces Neutrophil Reverse Transendothelial Migration in Sepsis.
Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress.
Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis.
Cold-inducible RNA-binding protein activates splenic T cells during sepsis in a TLR4-dependent manner.
Cold-inducible RNA-binding protein causes endothelial dysfunction via activation of Nlrp3 inflammasome.
Cold-inducible RNA-binding Protein Induces Neutrophil Extracellular Traps in the Lungs during Sepsis.
Damage-Associated Molecular Patterns as Double-Edged Swords in Sepsis.
Extracellular CIRP Induces Inflammation in Alveolar Type II Cells via TREM-1.
Extracellular microRNA 130b-3p inhibits eCIRP-induced inflammation.
The Cold-Inducible RNA-Binding Protein (CIRP) Level in Peripheral Blood Predicts Sepsis Outcome.
Severe Acute Respiratory Syndrome
"Bucket brigade" using lysine residues in RNA-dependent RNA polymerase of SARS-CoV-2.
A mini-review on sofosbuvir and daclatasvir treatment in coronavirus disease 2019.
A nanoscale genosensor for early detection of COVID-19 by voltammetric determination of RNA-dependent RNA polymerase (RdRP) sequence of SARS-CoV-2 virus.
A promising antiviral candidate drug for the COVID-19 pandemic: A mini-review of remdesivir.
Allosteric Activation of SARS-CoV-2 RNA-Dependent RNA Polymerase by Remdesivir Triphosphate and Other Phosphorylated Nucleotides.
Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates.
Brief comparative evaluation of six open one-step RT-qPCR mastermixes for the detection of SARS-CoV-2 RNA using a Taqman probe.
Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP.
Characterization of the NiRAN domain from RNA-dependent RNA polymerase provides insights into a potential therapeutic target against SARS-CoV-2.
Chemical constituents from coconut waste and their in silico evaluation as potential antiviral agents against SARS-CoV-2.
Comparative Evaluation of Tears and Nasopharyngeal Swab for SARS-CoV-2 in COVID-19 Dedicated Intensive Care Unit Patients.
Comparative in vivo analysis of the nsp15 endoribonuclease of murine, porcine and severe acute respiratory syndrome coronaviruses.
Comprehensive structural analysis of designed incomplete polypeptide chains of the replicase nonstructural protein 1 from the severe acute respiratory syndrome coronavirus.
Conserved HLA binding peptides from five non-structural proteins of SARS-CoV-2-An in silico glance.
Coronavirus genomic nsp14-ExoN, structure, role, mechanism, and potential application as a drug target.
Coronavirus replication-transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit.
Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs.
Delayed Development of Coronary Artery Dilitation in Suspected Severe Acute Respiratory Syndrome Coronavirus 2 Multisystem Inflammatory Syndrome: More Research Needed.
Development of a Simple In Vitro Assay To Identify and Evaluate Nucleotide Analogs against SARS-CoV-2 RNA-Dependent RNA Polymerase.
Discovery of (E)-N-(4-cyanobenzylidene)- 6-fluoro- 3-hydroxypyrazine-2 -carboxamide (cyanorona-20): the first potent and specific anti-COVID-19 drug.
Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10.
Evaluating the potential of different inhibitors on RNA-dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2: A molecular modeling approach.
Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets.
Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase.
High Fidelity of Murine Hepatitis Virus Replication Is Decreased in nsp14 Exoribonuclease Mutants.
High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from the Covid-19 severe acute respiratory syndrome coronavirus 2.
Human microRNA hsa-miR-15b-5p targets the RNA template component of the RNA-dependent RNA polymerase structure in severe acute respiratory syndrome coronavirus 2.
Immunoinformatics approach for multi-epitope vaccine design against structural proteins and ORF1a polyprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
In silico investigation to identify potential small molecule inhibitors of the RNA-dependent RNA polymerase (RdRp) nidovirus RdRp-associated nucleotidyltransferase domain.
Infectious Bronchitis Coronavirus Limits Interferon Production by Inducing a Host Shutoff That Requires Accessory Protein 5b.
Interface-based design of the favipiravir-binding site in SARS-CoV-2 RNA-dependent RNA polymerase reveals mutations conferring resistance to chain termination.
Interference of ribosomal frameshifting by antisense peptide nucleic acids suppresses SARS coronavirus replication.
Is oseltamivir suitable for fighting against COVID-19: In silico assessment, in vitro and retrospective study.
Mass spectrometric based detection of protein nucleotidylation in the RNA polymerase of SARS-CoV-2.
MAVS-mediated apoptosis and its inhibition by viral proteins.
Micronutrients and bioactive substances: Their potential roles in combating COVID-19.
Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template.
Multivalent binding of the partially disordered SARS-CoV-2 nucleocapsid phosphoprotein dimer to RNA.
Natural plant products as potential inhibitors of RNA dependent RNA polymerase of Severe Acute Respiratory Syndrome Coronavirus-2.
NeoCoV Is Closer to MERS-CoV than SARS-CoV.
NMR Structure of the SARS-CoV Nonstructural Protein 7 in Solution at pH 6.5.
Novel beta-barrel fold in the nuclear magnetic resonance structure of the replicase nonstructural protein 1 from the severe acute respiratory syndrome coronavirus.
Novel Development of Predictive Feature Fingerprints to Identify Chemistry-Based Features for the Effective Drug Design of SARS-CoV-2 Target Antagonists and Inhibitors Using Machine Learning.
Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus.
One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities.
One-pot pre-coated interface proximity extension assay for ultrasensitive co-detection of anti-SARS-CoV-2 antibodies and viral RNA.
Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12.
Prediction of Small Molecule Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus-2 RNA-dependent RNA Polymerase.
Rational engineering the DNA tetrahedrons of dual wavelength ratiometric electrochemiluminescence biosensor for high efficient detection of SARS-CoV-2 RdRp gene by using entropy-driven and bipedal DNA walker amplification strategy.
Remdesivir (GS-5734) in COVID-19 Therapy: The Fourth Chance.
Remdesivir analogs against SARS-CoV-2 RNA-dependent RNA polymerase.
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency.
RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex.
Role for nonstructural protein 1 of severe acute respiratory syndrome coronavirus in chemokine dysregulation.
SARS coronavirus protein nsp1 disrupts localization of Nup93 from the nuclear pore complex.
Sequence requirements of the FFAT-like motif for specific binding to VAP-A are revealed by NMR.
Severe acute respiratory syndrome coronavirus protein nsp1 is a novel eukaryotic translation inhibitor that represses multiple steps of translation initiation.
Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA.
Structural Basis and Function of the N Terminus of SARS-CoV-2 Nonstructural Protein 1.
Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex.
Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.
Structure of replicating SARS-CoV-2 polymerase.
Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP.
Targeting the RdRp of Emerging RNA Viruses: The Structure-Based Drug Design Challenge.
Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action.
The potential chemical structure of anti-SARS-CoV-2 RNA-dependent RNA polymerase.
The potential of Paritaprevir and Emetine as inhibitors of SARS-CoV-2 RdRp.
The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent.
The SARS coronavirus nucleocapsid protein--forms and functions.
The severe acute respiratory syndrome coronavirus Nsp15 protein is an endoribonuclease that prefers manganese as a cofactor.
Theoretical Analysis Reveals the Cost and Benefit of Proofreading in Coronavirus Genome Replication.
Third force in the treatment of COVID-19: A systematic review and meta-analysis.
Viral targets of acylguanidines.
Severe Dengue
A T164S mutation in the dengue virus NS1 protein is associated with greater disease severity in mice.
An Evidence-Based Algorithm for Early Prognosis of Severe Dengue in the Outpatient Setting.
Cyclic Dinucleotide-Adjuvanted Dengue Virus Nonstructural Protein 1 Induces Protective Antibody and T Cell Responses.
Differentially expressed genes of human microvascular endothelial cells in response to anti-dengue virus NS1 antibodies by suppression subtractive hybridization.
Elevated dengue virus nonstructural protein 1 serum levels and altered toll-like receptor 4 expression, nitric oxide, and tumor necrosis factor alpha production in dengue hemorrhagic Fever patients.
High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever.
High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity.
How NS1 Antibodies Prevent Severe Flavivirus Disease.
Nonstructural protein NS1 immunodominant epitope detected specifically in dengue virus infected material by a SELDI-TOF/MS based assay.
Nucleotide sequences of the nonstructural protein NS1 gene of three dengue-2 viruses, M1, M2 and M3, isolated in Malaysia from patients with dengue haemorrhagic fever, dengue shock syndrome and dengue fever, respectively.
Severe Fever with Thrombocytopenia Syndrome
Hijacking of RIG-I Signaling Proteins into Virus-Induced Cytoplasmic Structures Correlates with the Inhibition of Type I Interferon Responses.
Nonstructural Protein NSs Hampers Cellular Antiviral Response through LSm14A during Severe Fever with Thrombocytopenia Syndrome Virus Infection.
Nonstructural Protein of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Inhibits TBK1 to Evade Interferon-Mediated Response.
Nonstructural protein of severe fever with thrombocytopenia syndrome phlebovirus targets STAT2 and not STAT1 to inhibit type I interferon-stimulated JAK-STAT signaling.
Roles of viroplasm-like structures formed by nonstructural protein NSs in infection with severe fever with thrombocytopenia syndrome virus.
Severe Fever with Thrombocytopenia Syndrome Virus NSs Interacts with TRIM21 To Activate the p62-Keap1-Nrf2 Pathway.
Suppression of the IFN-? and -? Induction through Sequestering IRF7 into Viral Inclusion Bodies by Nonstructural Protein NSs in Severe Fever with Thrombocytopenia Syndrome Bunyavirus Infection.
Two Conserved Amino Acids within the NSs of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Are Essential for Anti-interferon Activity.
Shock, Septic
Cold-inducible RNA-binding protein mediates neuroinflammation in cerebral ischemia.
Shwachman-Diamond Syndrome
The Shwachman-Bodian-Diamond syndrome gene encodes an RNA-binding protein that localizes to the pseudopod of Dictyostelium amoebae during chemotaxis.
Sjogren's Syndrome
Phage-displayed La/SS-B antigen as a diagnostic reagent.
The Ro 60 kDa autoantigen comes into focus: interpreting epitope mapping experiments on the basis of structure.
The Ro 60 kDa autoantigen: insights into cellular function and role in autoimmunity.
Skin Diseases
Interaction of BP180 (type XVII collagen) and alpha6 integrin is necessary for stabilization of hemidesmosome structure.
Skin Neoplasms
Cytoplasmic accumulation of the RNA-binding protein HuR stabilizes the ornithine decarboxylase transcript in a murine nonmelanoma skin cancer model.
Sleep Deprivation
Cold-inducible RNA-binding protein (CIRBP) adjusts clock-gene expression and REM-sleep recovery following sleep deprivation.
Small Cell Lung Carcinoma
Application of Serum ELAVL4 (HuD) Antigen Assay for Small Cell Lung Cancer Diagnosis.
KH-type splicing regulatory protein (KHSRP) contributes to tumorigenesis by promoting miR-26a maturation in small cell lung cancer.
Spinal Cord Injuries
Adult neural stem cells and central nervous system repair.
Spinocerebellar Ataxias
Ataxin-2: From RNA Control to Human Health and Disease.
Conserved role for Ataxin-2 in mediating endoplasmic reticulum dynamics.
Nonapoptotic cell death caused by the inhibition of RNA polymerase disrupts organelle distribution.
Spotted Fever Group Rickettsiosis
Characterization of mutations in the rpoB gene in naturally rifampin-resistant Rickettsia species.
Squamous Cell Carcinoma of Head and Neck
Characterization of squamous cell carcinoma in an organotypic culture via subsurface non-linear optical molecular imaging.
Implication of RNA-binding protein La in proliferation, migration and invasion of lymph node-metastasized hypopharyngeal SCC cells.
Muscle-Specific FXR1 Isoforms in Squamous Cell Cancer.
Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma.
RNA-binding protein CELF1 promotes tumor growth and alters gene expression in oral squamous cell carcinoma.
The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2.
Staphylococcal Infections
Sequencing and staphylococci identification.
Starvation
6S RNA plays a role in recovery from nitrogen depletion in Synechocystis sp. PCC 6803.
ALBA proteins are stage regulated during trypanosome development in the tsetse fly and participate in differentiation.
Alteration of the growth-rate-dependent regulation of Escherichia coli tyrT expression by promoter mutations.
Alterations in DRBD3 ribonucleoprotein complexes in response to stress in Trypanosoma brucei.
Amino acid starvation affects the initiation frequency of nucleolar RNA polymerase.
Binding interface between the Salmonella ?(S)/RpoS subunit of RNA polymerase and Crl: hints from bacterial species lacking crl.
Characterization of four orthologs of stringent starvation protein A.
Characterization of the auxin-regulated par gene from tobacco mesophyll protoplasts.
Control of ribonucleic acid synthesis in eukaryotes. 2. The effect of protein synthesis on the activities of nuclear and total DNA-dependent RNA polymerase in yeast.
DksA represses ribosomal gene transcription in Pseudomonas aeruginosa by interacting with RNA polymerase on ribosomal promoters.
DNA polymerase III protein, HolC, helps resolve replication/transcription conflicts.
Effects of environmental stresses on the activities of the uspA, grpE and rpoS promoters of Escherichia coli O157:H7.
Elevated mutation frequency in surviving populations of carbon-starved rpoS-deficient Pseudomonas putida is caused by reduced expression of superoxide dismutase and catalase.
Error-prone DNA polymerase IV is controlled by the stress-response sigma factor, RpoS, in Escherichia coli.
Escherichia coli SspA is a transcription activator for bacteriophage P1 late genes.
Expanding the RpoS/?S-network by RNA sequencing and identification of ?S-controlled small RNAs in Salmonella.
Expression of different-size transcripts from the clpP-clpX operon of Escherichia coli during carbon deprivation.
Expression, crystallization and preliminary crystallographic analysis of the PAS domain of RsbP, a stress-response phosphatase from Bacillus subtilis.
Fitness costs of rifampicin resistance in Mycobacterium tuberculosis are amplified under conditions of nutrient starvation and compensated by mutation in the ?' subunit of RNA polymerase.
Growth phase-dependent expression of the Pseudomonas putida KT2440 transcriptional machinery analysed with a genome-wide DNA microarray.
Growth rate regulation in Escherichia coli.
Guanosine 3',5'-bispyrophosphate coordinates global gene expression during glucose-lactose diauxie in Escherichia coli.
Heat shock regulation of sigmaS turnover: a role for DnaK and relationship between stress responses mediated by sigmaS and sigma32 in Escherichia coli.
Increased Bioplastic Production with an RNA Polymerase Sigma Factor SigE during Nitrogen Starvation in Synechocystis sp. PCC 6803.
Initiation of transcription-coupled repair characterized at single-molecule resolution.
Isolation and characterization of the gene encoding the principal sigma factor of the vegetative cell RNA polymerase from the cyanobacterium Anabaena sp. strain PCC 7120.
Magic spots cast a spell on DNA primase.
Mechanisms of physiological regulation of RNA synthesis in bacteria: new discoveries breaking old schemes.
Mode of initiation of constitutive stable DNA replication in RNase H-defective mutants of Escherichia coli K-12.
Modulating RssB activity: IraP, a novel regulator of {sigma}S stability in Escherichia coli.
Multiple signaling pathways in gene expression during sugar starvation. Pharmacological analysis of din gene expression in suspension-cultured cells of Arabidopsis.
Negative control of rpoS expression by phosphoenolpyruvate: carbohydrate phosphotransferase system in Escherichia coli.
Phosphorylation of RNA polymerase I-associated polypeptides of Tetrahymena pyriformis.
Polyphosphate binds to the principal sigma factor of RNA polymerase during starvation response in Helicobacter pylori.
ppGpp inhibits the activity of Escherichia coli DnaG primase.
Regulation in the synthesis of Escherichia coli RNA polymerase proposed from sequence analysis.
relA-dependent RNA polymerase activity in Escherichia coli.
Role of putrescine in regulation of the sigmaS subunit of RNA polymerase in Escherichia coli cells on transition to stationary phase.
Role of the sigma 70 subunit of RNA polymerase in transcriptional activation by activator protein PhoB in Escherichia coli.
SigmaS-dependent gene expression at the onset of stationary phase in Escherichia coli: function of sigmaS-dependent genes and identification of their promoter sequences.
Structural basis for transcription inhibition by E. coli SspA.
Studies in vivo on Escherichia coli RNA polymerase mutants altered in the stringent response.
Subunits of RNA polymerase in function and structure. IX. Regulation of RNA polymerase activity by stringent starvation protein (SSP).
The effect of cyclic nucleotides on cellular ATP levels and ribosomal RNA synthesis in Ehrlich ascites cells.
The mediator for stringent control, ppGpp, binds to the beta-subunit of Escherichia coli RNA polymerase.
The RNA antiterminator causes transcription pausing in the leader region of the tryptophan operon.
The Role of Replication Clamp-Loader Protein HolC of Escherichia coli in Overcoming Replication/Transcription Conflicts.
The role of the omega subunit of RNA polymerase in expression of the relA gene in Escherichia coli.
Toxic effects of high levels of ppGpp in Escherichia coli are relieved by rpoB mutations.
Transcription of ribosomal component genes and lac in a relA+/relA pair of Escherichia coli strains.
Translational regulation of the Escherichia coli stress factor RpoS: a role for SsrA and Lon.
Yeast Sporulation and [SMAUG+] Prion: Faster Is Not Always Better.
[Differential protein analysis on the root response of rice with high phosphorous uptake efficiency to low phosphorous stress].
[Stationary phase in Escherichia coli]
Still's Disease, Adult-Onset
Clinical relevance for circulating cold-inducible RNA-binding protein (CIRP) in patients with adult-onset Still's disease.
Stomach Neoplasms
A Novel RNA-Binding Protein Signature to Predict Clinical Outcomes and Guide Clinical Therapy in Gastric Cancer.
LARP7 is a potential tumor suppressor gene in gastric cancer.
Long non-coding RNA Loc490 inhibits gastric cancer cell proliferation and metastasis by upregulating RNA-binding protein Quaking.
Long noncoding RNA LINC00982 upregulates CTSF expression to inhibit gastric cancer progression via the transcription factor HEY1.
NME2 Is a Master Suppressor of Apoptosis in Gastric Cancer Cells via Transcriptional Regulation of miR-100 and Other Survival Factors.
Poly(rC) binding protein 2 (PCBP2) promotes the viability of human gastric cancer cells by regulating CDK2.
RNA-binding protein RBM38 acts as a tumor suppressor in gastric cancer.
RNA-binding protein RNPC1 acts as an oncogene in gastric cancer by stabilizing aurora kinase B mRNA.
The Aberrant Expression of MicroRNA-125a-5p/IGF2BP3 Axis in Advanced Gastric Cancer and Its Clinical Relevance.
The RNA-Binding Protein DDX18 Promotes Gastric Cancer by Affecting the Maturation of MicroRNA-21.
The RNA-Binding Protein NELFE Promotes Gastric Cancer Growth and Metastasis Through E2F2.
Stomatitis
Inhibition of caspases protects mice from radiation-induced oral mucositis and abolishes the cleavage of RNA-binding protein HuR.
Stroke
Analytical theory of the nonequilibrium spatial distribution of RNA polymerase translocations.
Monocyte function and plasma levels of interleukin-8 in acute ischemic stroke.
The nucleotide addition cycle of the SARS-CoV-2 polymerase.
Stuttering
A mutant RNA polymerase reveals a kinetic mechanisms for the switch between nonproductive stuttering synthesis and productive initiation during promoter clearance.
Genome rearrangement affects RNA virus adaptability on prostate cancer cells.
Nucleotide sequences and mapping of novel heterogenous 5'-termini of adenovirus 2 early region 4 mRNA.
Paramyxovirus mRNA editing leads to G deletions as well as insertions.
The versatility of paramyxovirus RNA polymerase stuttering.
[RNA editing]
Subacute Sclerosing Panencephalitis
Characterization of an RNA-dependent RNA polymerase activity associated with measles virus.
Effect of promoter mutations and upstream deletions on the expression of genes coding for small, acid-soluble spore proteins of Bacillus subtilis.
Identification of a new sigma-factor involved in compartmentalized gene expression during sporulation of Bacillus subtilis.
Superinfection
A Novel Role for PDZ-Binding Motif of Influenza A Virus Nonstructural Protein 1 in Regulation of Host Susceptibility to Postinfluenza Bacterial Superinfections.
Mutational analysis of influenza virus promoter elements in vivo.
Mutational analysis of the Uukuniemi virus (Bunyaviridae family) promoter reveals two elements of functional importance.
Structural basis of transcription arrest by coliphage HK022 Nun in an
The repeated regions of Semliki Forest virus defective-inferfering RNA interferes with the encapsidation process of the standard virus.
The Y39A mutation of HK022 Nun disrupts a boxB interaction but preserves termination activity.
Swine Vesicular Disease
The N-terminal region of the VP1 protein of swine vesicular disease virus contains a neutralization site that arises upon cell attachment and is involved in viral entry.
Tauopathies
AlphaScreen Identifies MSUT2 Inhibitors for Tauopathy-Targeting Therapeutic Discovery.
TDP-43 Proteinopathies
Structural Transition, Function and Dysfunction of TDP-43 in Neurodegenerative Diseases.
TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD.
Teratoma
Mammalian germ cells are determined after PGC colonization of the nascent gonad.
The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming.
Translational repression of cyclin E prevents precocious mitosis and embryonic gene activation during C. elegans meiosis.
Thrombocytopenia
Deadly intracranial bleed in patients with dengue fever: A series of nine patients and review of literature.
Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage.
Fatal Intracranial Hemorrhage in a Patient with Severe Dengue Fever.
Hijacking of RIG-I Signaling Proteins into Virus-Induced Cytoplasmic Structures Correlates with the Inhibition of Type I Interferon Responses.
Nonstructural Protein NSs Hampers Cellular Antiviral Response through LSm14A during Severe Fever with Thrombocytopenia Syndrome Virus Infection.
Nonstructural Protein of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Inhibits TBK1 to Evade Interferon-Mediated Response.
Nonstructural protein of severe fever with thrombocytopenia syndrome phlebovirus targets STAT2 and not STAT1 to inhibit type I interferon-stimulated JAK-STAT signaling.
Roles of viroplasm-like structures formed by nonstructural protein NSs in infection with severe fever with thrombocytopenia syndrome virus.
Severe Fever with Thrombocytopenia Syndrome Virus NSs Interacts with TRIM21 To Activate the p62-Keap1-Nrf2 Pathway.
Suppression of the IFN-? and -? Induction through Sequestering IRF7 into Viral Inclusion Bodies by Nonstructural Protein NSs in Severe Fever with Thrombocytopenia Syndrome Bunyavirus Infection.
Two Conserved Amino Acids within the NSs of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Are Essential for Anti-interferon Activity.
Thrombosis
Lung transcriptome of a COVID-19 patient and systems biology predictions suggest impaired surfactant production which may be druggable by surfactant therapy.
The Role of PB1 Domain Proteins in Endothelial Cell Dysfunction and Disease.
Thyroid Cancer, Papillary
miR-31 Reduces Cell Growth of Papillary Thyroid Carcinoma by RNA-Binding Protein HuR.
Thyroid Neoplasms
Effects of HuR downregulation on anaplastic thyroid cancer cells.
Identification of tumorigenesis-related mRNAs associated with RNA-binding protein HuR in thyroid cancer cells.
Triple Negative Breast Neoplasms
Long non-coding RNA LINC-PINT attenuates paclitaxel resistance in triple-negative breast cancer cells via targeting the RNA-binding protein NONO.
RNA-binding protein MSI2 isoforms expression and regulation in progression of triple-negative breast cancer.
TDP-43 is Required for Mammary Gland Repopulation and Proliferation of Mammary Epithelial Cells.
Therapeutic targeting of transcriptional cyclin-dependent kinases.
Tuberculosis
A mycobacterial extracytoplasmic function sigma factor involved in survival following stress.
A recombinant Mycobacterium tuberculosis in vitro transcription system.
A universal probe design for colorimetric detection of single-nucleotide variation with visible readout and high specificity.
Alteration of ribosomes and RNA polymerase in drug-resistant clinical isolates of Mycobacterium tuberculosis.
Altered Fatty Acid Metabolism Due to Rifampicin-Resistance Conferring Mutations in the rpoB Gene of Mycobacterium tuberculosis: Mapping the Potential of Pharmaco-metabolomics for Global Health and Personalized Medicine.
Analysis of RNA polymerase gene mutation in three isolates of rifampicin resistant Mycobacterium tuberculosis.
Antimicrobial agent resistance in mycobacteria: molecular genetic insights.
Association of ? with the C-Terminal Region of the ?' Subunit Is Essential for Assembly of RNA Polymerase in Mycobacterium tuberculosis.
Bifidobacterium adolescentis is intrinsically resistant to antitubercular drugs.
CarD and RbpA modify the kinetics of initial transcription and slow promoter escape of the Mycobacterium tuberculosis RNA polymerase.
CarD contributes to diverse gene expression outcomes throughout the genome of Mycobacterium tuberculosis.
Cascade of extracytoplasmic function sigma factors in Mycobacterium tuberculosis: identification of a sigmaJ-dependent promoter upstream of sigI.
Cell-Based High-Throughput Screening Identifies Rifapentine as an Inhibitor of Amyloid and Biofilm Formation in Escherichia coli.
Characterization by automated DNA sequencing of mutations in the gene (rpoB) encoding the RNA polymerase beta subunit in rifampin-resistant Mycobacterium tuberculosis strains from New York City and Texas.
Characterization of Mutations Conferring Resistance to Rifampin in Mycobacterium tuberculosis Clinical Strains.
Characterization of spontaneous, In vitro-selected, rifampin-resistant mutants of Mycobacterium tuberculosis strain H37Rv.
Characterization of Tunisian Mycobacterium tuberculosis rifampin-resistant clinical isolates.
Chemical cleavage of mismatches in heteroduplexes of the rpoB gene for detection of mutations associated with resistance of Mycobacterium tuberculosis to rifampin.
Clinical evaluation of a 16S ribosomal RNA polymerase chain reaction test for the diagnosis of lymph node tuberculosis.
Co-inhibition as a strategic therapeutic approach to overcome rifampin resistance in tuberculosis therapy: atomistic insights.
Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations.
Consensus numbering system for the rifampicin resistance-associated rpoB gene mutations in pathogenic mycobacteria.
Construction and characterization of a Mycobacterium tuberculosis mutant lacking the alternate sigma factor gene, sigF.
Crystal structure of Mycobacterium tuberculosis CarD, an essential RNA polymerase binding protein, reveals a quasidomain-swapped dimeric structural architecture.
Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death.
Detection of Mycobacterium tuberculosis directly from sputum by using a prototype automated Q-beta replicase assay.
Development of a novel secondary phenotypic screen to identify hits within the mycobacterial protein synthesis pipeline.
Different rifampin sensitivities of Escherichia coli and Mycobacterium tuberculosis RNA polymerases are not explained by the difference in the beta-subunit rifampin regions I and II.
Differential identification of Mycobacterium tuberculosis complex and nontuberculous mycobacteria by duplex PCR assay using the RNA polymerase gene (rpoB).
Direct genotypic detection of Mycobacterium tuberculosis rifampin resistance in clinical specimens by using single-tube heminested PCR.
Discovery of a capuramycin analog that kills nonreplicating Mycobacterium tuberculosis and its synergistic effects with translocase I inhibitors.
Distinct and Contrasting Transcription Initiation Patterns at Mycobacterium tuberculosis Promoters.
Distinct Mechanism Evolved for Mycobacterial RNA Polymerase and Topoisomerase I Protein-Protein Interaction.
Effects of Increasing the Affinity of CarD for RNA Polymerase on Mycobacterium tuberculosis Growth, rRNA Transcription, and Virulence.
Enhanced immunogenicity to Mycobacterium tuberculosis by vaccination with an alphavirus plasmid replicon expressing antigen 85A.
Essentiality of DevR/DosR interaction with SigA for the dormancy survival program in Mycobacterium tuberculosis.
Evaluation of the INNO-LiPA Rif. TB assay, a reverse hybridization assay for the simultaneous detection of Mycobacterium tuberculosis complex and its resistance to rifampin.
Evolutionary comparison of ribosomal operon antitermination function.
Fitness costs of rifampicin resistance in Mycobacterium tuberculosis are amplified under conditions of nutrient starvation and compensated by mutation in the ?' subunit of RNA polymerase.
Fitness-compensatory mutations in rifampicin-resistant RNA polymerase.
Functional insights into Mycobacterium tuberculosis DevR-dependent transcriptional machinery utilizing Escherichia coli.
Genome-wide Definition of the SigF Regulon in Mycobacterium tuberculosis.
Genome-Wide Mapping of the Distribution of CarD, RNAP ?(A), and RNAP ? on the Mycobacterium smegmatis Chromosome using Chromatin Immunoprecipitation Sequencing.
High-resolution transcriptome and genome-wide dynamics of RNA polymerase and NusA in Mycobacterium tuberculosis.
Homology modeling of wild-type, D516V, and H526L Mycobacterium tuberculosis RNA polymerase and their molecular docking study with inhibitors.
Identification and characterization of pleiotropic high-persistence mutations in the beta subunit of the bacterial RNA polymerase.
Identification and characterization of the dps promoter of Mycobacterium smegmatis: promoter recognition by stress-specific extracytoplasmic function sigma factors sigmaH and sigmaF.
Identification of mutations in the rpoB encoding the RNA polymerase beta subunit in rifampicine-resistant Mycobacterium tuberculosis strains from Iran.
Identification of new antibacterial targets in RNA polymerase of Mycobacterium tuberculosis by detecting positive selection sites.
Identification of promoters recognized by RNA polymerase containing Mycobacterium tuberculosis stress-response sigma factor sigma(F).
Implication from the predicted docked interaction of sigma H and exploration of its interaction with RNA polymerase in Mycobacterium tuberculosis.
Inhibition of Mycobacterium tuberculosis RNA polymerase by binding of a Gre factor homolog to the secondary channel.
Isolation of the gene for the beta subunit of RNA polymerase from rifampicin-resistant Mycobacterium tuberculosis and identification of new mutations.
Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis.
Lost in transcription--inhibition of RNA polymerase.
Mechanistic Principles Behind Molecular Mechanism of Rifampicin Resistance in Mutant RNA Polymerase Beta Subunit of Mycobacterium tuberculosis.
Molecular characterization of mutation associated with rifampicin and isoniazid resistance in Mycobacterium tuberculosis isolates.
Molecular mechanisms of drug resistance in Mycobacterium tuberculosis clinical isolates.
Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives.
Mutation Analysis of Mycobacterial rpoB Genes and Rifampicin Resistance Using Recombinant Mycobacterium smegmatis.
Mutation position and type of substitution in the beta-subunit of the RNA polymerase influence in-vitro activity of rifamycins in rifampicin-resistant Mycobacterium tuberculosis.
Mutational Frequencies in Mycobacterial rpoB gene using GeneXpert/MTB Rif Assay in Rifampicin Resistant patients at a tertiary care setting in Urban Sindh, Pakistan: Analysis from a Five-Year Period.
Mutations in rpoB gene of rifampicin resistant clinical isolates of Mycobacterium tuberculosis in Japan.
Mutations of rpob Gene Associated with Rifampin Resistance among Mycobacterium Tuberculosis Isolated in Tuberculosis Regional Reference Laboratory in Northeast of Iran during 2015-2016.
Mycobacterium RbpA cooperates with the stress-response ?B subunit of RNA polymerase in promoter DNA unwinding.
Mycobacterium tuberculosis CarD, an essential global transcriptional regulator forms amyloid-like fibrils.
Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set.
Mycobacterium tuberculosis RbpA protein is a new type of transcriptional activator that stabilizes the ?A-containing RNA polymerase holoenzyme.
Mycobacterium tuberculosis RNA polymerase-binding protein A (RbpA) and its interactions with sigma factors.
Mycobacterium tuberculosis Rv1474c is a TetR-like transcriptional repressor that regulates aconitase, an essential enzyme and RNA-binding protein, in an iron-responsive manner.
Novel mechanism of gene regulation: the protein Rv1222 of Mycobacterium tuberculosis inhibits transcription by anchoring the RNA polymerase onto DNA.
Optimization of a two-plasmid system for the identification of promoters recognized by RNA polymerase containing Mycobacterium tuberculosis stress response sigma factor, sigmaF.
Optimization of recombinant Mycobacterium tuberculosis RNA polymerase expression and purification.
Performance of an automated Q-beta replicase amplification assay for Mycobacterium tuberculosis in a clinical trial.
Probing the Molecular Mechanism of Rifampin Resistance Caused by the Point Mutations S456L and D441V on Mycobacterium tuberculosis RNA Polymerase through Gaussian Accelerated Molecular Dynamics Simulation.
Production and characterization of a highly pure RNA polymerase holoenzyme from Mycobacterium tuberculosis.
Prospective evaluation of the utility of molecular techniques for diagnosing nosocomial transmission of multidrug-resistant tuberculosis.
Pulmonary tuberculosis in the West Bank, Palestinian Authority: molecular diagnostic approach.
Purification and properties of DNA-dependent RNA polymerase from Mycobacterium tuberculosis H37RV.
Q-beta replicase-amplified assay for detection of Mycobacterium tuberculosis directly from clinical specimens.
Rapid detection of mutations in rpoB gene of rifampicin resistant Mycobacterium tuberculosis strains by line probe assay.
Rapid detection of rpoB gene mutations conferring rifampin resistance in Mycobacterium tuberculosis.
RbpA relaxes promoter selectivity of M. tuberculosis RNA polymerase.
Recombinant reporter assay using transcriptional machinery of Mycobacterium tuberculosis.
Resistance profiles and rpoB gene mutations of Mycobacterium tuberculosis isolates in Taiwan.
Restriction endonuclease analysis as a solution for determining rifampin resistance mutations by automated DNA sequencing in heteroresistant Mycobacterium tuberculosis strains.
Rifampin induces hydroxyl radical formation in Mycobacterium tuberculosis.
Rifampin-resistance-associated mutations in the rifampin-resistance-determining region of the rpoB gene of Mycobacterium tuberculosis clinical isolates in Shanghai, PR China.
Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations.
Robust Strand Exchange Reactions for the Sequence-Specific, Real-Time Detection of Nucleic Acid Amplicons.
Role of 5'-TGN-3' motif in the interaction of mycobacterial RNA polymerase with a promoter of 'extended -10' class.
Role of an RNA polymerase interacting protein, MsRbpA, from Mycobacterium smegmatis in phenotypic tolerance to rifampicin.
Routine rapid Mycobacterium species assignment based on species-specific allelic variation in the 65-kilodalton heat shock protein gene (hsp65).
Rv0474 is a copper-responsive transcriptional regulator that negatively regulates expression of RNA polymerase ? subunit in Mycobacterium tuberculosis.
Screening of African medicinal plants for antimicrobial and enzyme inhibitory activity.
Sigma factor F does not prevent rifampin inhibition of RNA polymerase or cause rifampin tolerance in Mycobacterium tuberculosis.
Simultaneous identification of rifampin-resistant Mycobacterium tuberculosis and nontuberculous mycobacteria by polymerase chain reaction-single strand conformation polymorphism and sequence analysis of the RNA polymerase gene (rpoB).
Source of the Fitness Defect in Rifamycin-Resistant Mycobacterium tuberculosis RNA Polymerase and the Mechanism of Compensation by Mutations in the ?' Subunit.
Structural analysis of sigma E interactions with core RNA polymerase and its cognate P-hsp20 promoter of Mycobacterium tuberculosis.
Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Structural basis of ECF-?-factor-dependent transcription initiation.
Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7.
Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae.
Structural insights into the functional divergence of WhiB-like proteins in Mycobacterium tuberculosis.
Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures.
Structure and function of CarD, an essential mycobacterial transcription factor.
Structure of the carboxy-terminal domain of Mycobacterium tuberculosis CarD protein: an essential rRNA transcriptional regulator.
Structures of the Catalytic Domain of Bacterial Primase DnaG in Complexes with DNA Provide Insight into Key Priming Events.
Study of Genetic Evolution in Mycobacterium tuberculosis Isolates from Patients with Active Pulmonary Tuberculosis in the Iran and Belarus.
Synergistic Interplay of The Co-administration of Rifampin And Newly Developed Anti-TB Drug: Could It Be a Promising New Line of TB Therapy?
The actinobacterial transcription factor RbpA binds to the principal sigma subunit of RNA polymerase.
The Enzymes of the Rifamycin Antibiotic Resistome.
The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase.
The rpoB gene of Mycobacterium tuberculosis.
Transcription of two sigma 70 homologue genes, sigA and sigB, in stationary-phase Mycobacterium tuberculosis.
Uncovering the Resistance Mechanism of Mycobacterium tuberculosis to Rifampicin Due to RNA Polymerase H451D/Y/R Mutations From Computational Perspective.
Use of DNA extracts from Ziehl-Neelsen-stained slides for molecular detection of rifampin resistance and spoligotyping of Mycobacterium tuberculosis.
Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes.
[New inhibitors targeting bacterial RNA polymerase].
[Studies on mutation of rifampicin-resistant genes in M. tuberculosis]
Tuberculosis, Lymph Node
Clinical evaluation of a 16S ribosomal RNA polymerase chain reaction test for the diagnosis of lymph node tuberculosis.
Tuberculosis, Multidrug-Resistant
Combining COLD-PCR and high-resolution melt analysis for rapid detection of low-level, rifampin-resistant mutations in Mycobacterium tuberculosis.
Fitness costs of rifampicin resistance in Mycobacterium tuberculosis are amplified under conditions of nutrient starvation and compensated by mutation in the ?' subunit of RNA polymerase.
Tumor Virus Infections
RNA polymerase in cells infected with Shope fibroma virus.
Typhus, Epidemic Louse-Borne
Characterization of mutations in the rpoB gene in naturally rifampin-resistant Rickettsia species.
Urinary Bladder Neoplasms
Knockdown of mediator subunit Med19 suppresses bladder cancer cell proliferation and migration by downregulating Wnt/?-catenin signalling pathway.
Long non-coding RNA urothelial carcinoma associated 1 induces cell replication by inhibiting BRG1 in 5637 cells.
Re: Yves Allorya, Willemien Beukers, Ana Sagrera, et al. Telomerase Reverse Transcriptase Promoter Mutations in Bladder Cancer: High Frequency Across Stages, Detection in Urine, and Lack of Association with Outcome. Eur Urol 2014;65:360-6: Telomerase Expression and Stem Cells: Urologic Epithelial Perspective.
RNA-binding protein HuR promotes bladder cancer progression by competitively binding to the long noncoding HOTAIR with miR-1.
Uterine Cervical Neoplasms
Msi1 promotes tumor growth and cell proliferation by targeting cell cycle checkpoint proteins p21, p27 and p53 in cervical carcinomas.
Musashi-2, a novel oncoprotein promoting cervical cancer cell growth and invasion, is negatively regulated by p53-induced miR-143 and miR-107 activation.
Vaccinia
A cellular factor is required for transcription of vaccinia viral intermediate-stage genes.
A cellular protein binds vaccinia virus late promoters and activates transcription in vitro.
A freeze-frame view of eukaryotic transcription during elongation and capping of nascent mRNA.
A macrophage fusion assay for rapid screening of cloned HIV-1 Env using dual recombinant vaccinia viruses expressing distinct RNA polymerases.
A myxoma virus nucleotide sequence with homology to the vaccinia virus RNA polymerase 22-kDa subunit gene.
A potential role for the nucleolus in L1 retrotransposition.
A role for ATP hydrolysis in vaccinia virus early gene transcription. Dissociation of the early transcription factor-promoter complex.
A role for the H4 subunit of vaccinia RNA polymerase in transcription initiation at a viral early promoter.
A vaccinia virus isatin-beta-thiosemicarbazone resistance mutation maps in the viral gene encoding the 132-kDa subunit of RNA polymerase.
Adenosine N1-oxide inhibits vaccinia virus replication by blocking translation of viral early mRNAs.
An ATPase component of the transcription elongation complex is required for factor-dependent transcription termination by vaccinia RNA polymerase.
An isatin-beta-thiosemicarbazone-resistant vaccinia virus containing a mutation in the second largest subunit of the viral RNA polymerase is defective in transcription elongation.
Analysis of murine major histocompatibility complex class II-restricted T-cell responses to the flavivirus Kunjin by using vaccinia virus expression.
Analysis of respiratory syncytial virus F, G, and SH proteins in cell fusion.
Antibodies directed against an epitope in the N-terminal region of the H4L subunit of the vaccinia virus RNA polymerase inhibit both transcription initiation and transcription termination, in vitro.
Antitermination of vaccinia virus early transcription: possible role of RNA secondary structure.
Baculovirus-expressed nonstructural protein NS2 of bluetongue virus induces a cytotoxic T-cell response in mice which affords partial protection.
Biochemical and electron microscopic studies of the transcription of vaccinia DNA by RNA polymerase from Escherichia coli: localization and characterization of transcriptional complexes.
Bromouridine triphosphate inhibits transcription termination and mRNA release by vaccinia virions.
Cascade regulation of vaccinia virus gene expression is modulated by multistage promoters.
CD8 T Cell Responses to an Immunodominant Epitope within the Nonstructural Protein NS1 Provide Wide Immunoprotection against Bluetongue Virus in IFNAR-/- Mice.
Cells that express all five proteins of vesicular stomatitis virus from cloned cDNAs support replication, assembly, and budding of defective interfering particles.
Cellular expression of a functional nodavirus RNA replicon from vaccinia virus vectors.
Characterization of a vaccinia virus-encoded double-stranded RNA-binding protein that may be involved in inhibition of the double-stranded RNA-dependent protein kinase.
Codon usage-mediated inhibition of HIV-1 gag expression in mammalian cells occurs independently of translation.
Complementation of vaccinia virus lacking the double-stranded RNA-binding protein gene E3L by human cytomegalovirus.
Cross-protective immune responses against African horse sickness virus after vaccination with protein NS1 delivered by avian reovirus muNS microspheres and modified vaccinia virus Ankara.
Defective point mutants of the encephalomyocarditis virus internal ribosome entry site can be complemented in trans.
Detailed phenotypic characterization of five temperature-sensitive mutants in the 22- and 147-kilodalton subunits of vaccinia virus DNA-dependent RNA polymerase.
Detection of RNA-protein complex in vaccinia virus core in vitro transcription system.
Determinants of vaccinia virus early gene transcription termination.
Discovery of m(7)G-cap in eukaryotic mRNAs.
Discrete functional stages of vaccinia virus early transcription during a single round of RNA synthesis in vitro.
Double-stranded RNA-binding protein E3 controls translation of viral intermediate RNA, marking an essential step in the life cycle of modified vaccinia virus Ankara.
Effect of rifamycin derivatives and coumermycin A1 on in vitro RNA synthesis by African swine fever virus. Brief report.
Effect of selected mutations in the C-terminal region of the vaccinia virus nucleoside triphosphate phosphohydrolase I on binding to the H4L subunit of the viral RNA polymerase and early gene transcription termination in vitro.
Elongation properties of vaccinia virus RNA polymerase: pausing, slippage, 3' end addition, and termination site choice.
Emergence of a Viral RNA Polymerase Variant during Gene Copy Number Amplification Promotes Rapid Evolution of Vaccinia Virus.
Endothelial cell DNA transfer and expression using petri dish electroporation and the nonreplicating vaccinia virus/T7 RNA polymerase hybrid system.
Enhanced genetic rescue of negative-strand RNA viruses: use of an MVA-T7 RNA polymerase vector and DNA replication inhibitors.
Evasion of cellular antiviral responses by human cytomegalovirus TRS1 and IRS1.
Evidence for genetic relationship between RNA and DNA viruses from the sequence homology of a putative polymerase gene of bluetongue virus with that of vaccinia virus: conservation of RNA polymerase genes from diverse species.
Expansion of poxvirus RNA polymerase subunits sharing homology with corresponding subunits of RNA polymerase II.
Expression analysis of recombinant herpes simplex virus type 1 DNase.
Expression of dengue virus structural proteins and nonstructural protein NS1 by a recombinant vaccinia virus.
Expression of poliovirus P3 proteins using a recombinant vaccinia virus results in proteolytically active 3CD precursor protein without further processing to 3Cpro and 3Dpol.
Expression strategy of the M genome segment of Hantaan virus.
Factor-dependent release of nascent RNA by ternary complexes of vaccinia RNA polymerase.
Factor-dependent transcription termination by vaccinia RNA polymerase. Kinetic coupling and requirement for ATP hydrolysis.
Factor-dependent transcription termination by vaccinia virus RNA polymerase. Evidence that the cis-acting termination signal is in nascent RNA.
Failure of poxvirus replication in the presence of an inhibitor of nucleolar RNA synthesis.
Feline calicivirus capsid protein expression and self-assembly in cultured feline cells.
Fine structure mapping and phenotypic analysis of five temperature-sensitive mutations in the second largest subunit of vaccinia virus DNA-dependent RNA polymerase.
Fine structure mapping of five temperature-sensitive mutants in the 22- and 147-kilodalton subunits of vaccinia virus DNA-dependent RNA polymerase.
Functional expression of p64, an intracellular chloride channel protein.
Gene expression using the vaccinia virus/ T7 RNA polymerase hybrid system.
Gene expression using the vaccinia virus/T7 RNA polymerase hybrid system.
Generation of reovirus core-like particles in cells infected with hybrid vaccinia viruses that express genome segments L1, L2, L3, and S2.
High expression of human chorionic gonadotrophin beta-subunit using a synthetic vaccinia virus promoter.
High level transient expression of the murine coronavirus haemagglutinin-esterase.
Histidine codons appended to the gene encoding the RPO22 subunit of vaccinia virus RNA polymerase facilitate the isolation and purification of functional enzyme and associated proteins from virus-infected cells.
Homology between RNA polymerases of poxviruses, prokaryotes, and eukaryotes: nucleotide sequence and transcriptional analysis of vaccinia virus genes encoding 147-kDa and 22-kDa subunits.
Human cytomegalovirus-specific cytotoxic T cells. Relative frequency of stage-specific CTL recognizing the 72-kD immediate early protein and glycoprotein B expressed by recombinant vaccinia viruses.
Human immunodeficiency virus type 1 Vpu protein induces degradation of chimeric envelope glycoproteins bearing the cytoplasmic and anchor domains of CD4: role of the cytoplasmic domain in Vpu-induced degradation in the endoplasmic reticulum.
Hydrolytic cleavage of nascent RNA in RNA polymerase III ternary transcription complexes.
Identification and cloning of the fowlpox virus thymidine kinase gene using vaccinia virus.
Identification of a transcription factor, encoded by two vaccinia virus early genes, that regulates the intermediate stage of viral gene expression.
Identification of rpo30, a vaccinia virus RNA polymerase gene with structural similarity to a eucaryotic transcription elongation factor.
Identification of the vaccinia virus gene encoding an 18-kilodalton subunit of RNA polymerase and demonstration of a 5' poly(A) leader on its early transcript.
Identification of three H-2K(d) restricted CTL epitopes of NS4A and NS4B protein from Yellow fever 17D vaccine.
Identification of vaccinia promoters by heterologous expression of hepatitis B surface antigen in mouse cells infected by recombinant vaccinia viruses.
Identification, sequence, and expression of the gene encoding the second-largest subunit of the vaccinia virus DNA-dependent RNA polymerase.
Immunization of mice with recombinant vaccinia virus expressing authentic dengue virus nonstructural protein NS1 protects against lethal dengue virus encephalitis.
In vitro transcription of a cloned vaccinia virus gene by a soluble extract prepared from vaccinia virus-infected HeLa cells.
Inefficient complementation activity of poliovirus 2C and 3D proteins for rescue of lethal mutations.
Inhibition of the RNA polymerase III-mediated dsDNA-sensing pathway of innate immunity by vaccinia virus protein E3.
Interaction between nucleoside triphosphate phosphohydrolase I and the H4L subunit of the viral RNA polymerase is required for vaccinia virus early gene transcript release.
Interaction between the J3R subunit of vaccinia virus poly(A) polymerase and the H4L subunit of the viral RNA polymerase.
Interaction of the vaccinia virus RNA polymerase-associated protein of 94-kDa with the early transcription factor.
La Crosse virus nonstructural protein NSs counteracts the effects of short interfering RNA.
Localization of mouse hepatitis virus open reading frame 1A derived proteins.
Localization of the Vpx packaging signal within the C terminus of the human immunodeficiency virus type 2 Gag precursor protein.
M2 Macrophages Play Critical Roles in Progression of Inflammatory Liver Disease in Hepatitis C Virus Transgenic Mice.
Mapping and phenotypic analysis of spontaneous isatin-beta-thiosemicarbazone resistant mutants of vaccinia virus.
Mapping the interacting domains between the rabies virus polymerase and phosphoprotein.
Mechanisms of replication-deficient vaccinia virus/T7 RNA polymerase hybrid expression: effect of T7 RNA polymerase levels and alpha-amanitin.
Membrane permeabilization by poliovirus proteins 2B and 2BC.
Membrane-associated respiratory syncytial virus F protein expressed from a human rhinovirus type 14 vector is immunogenic.
Mice immunized with recombinant vaccinia virus expressing dengue 4 virus structural proteins with or without nonstructural protein NS1 are protected against fatal dengue virus encephalitis.
Mutagen activation by cDNA-expressed P(1)450, P(3)450, and P450a.
Mutational analysis identifies functional domains in the influenza A virus PB2 polymerase subunit.
Mutations in the DI-DII Linker of Human Parainfluenza Virus Type 3 Fusion Protein Result in Diminished Fusion Activity.
Mutations in the Leucine Zipper-Like Motif of the Human Parainfluenza Virus 3 Fusion Protein Impair Fusion Activity.
Nascent RNA cleavage by purified ternary complexes of vaccinia RNA polymerase.
Nuclear localization of a double-stranded RNA-binding protein encoded by the vaccinia virus E3L gene.
Ordered assembly of a functional preinitiation transcription complex, containing vaccinia virus early transcription factor and RNA polymerase, on an immobilized template.
Overexpression, purification, and late transcription factor activity of the 17-kilodalton protein encoded by the vaccinia virus A1L gene.
Phenotypic characterization of mutants in vaccinia virus gene G2R, a putative transcription elongation factor.
Physical and functional characterization of the double-stranded RNA binding protein encoded by the vaccinia virus E3 gene.
Polyamines stimulate DNA-dependent RNA synthesis catalyzed by vaccinia virus.
Process of cap formation of messenger RNA by vaccinia virus particles carrying an organized enzymes system.
Production of HIV-1 gp120 in packed-bed bioreactor using the vaccinia virus/T7 expression system.
Promoter DNA contacts made by the vaccinia virus early transcription factor.
Promoter melting by a stage-specific vaccinia virus transcription factor is independent of the presence of RNA polymerase.
Proteolytic processing of the porcine reproductive and respiratory syndrome virus replicase.
Purification and identification of a vaccinia virus-encoded intermediate stage promoter-specific transcription factor that has homology to eukaryotic transcription factor SII (TFIIS) and an additional role as a viral RNA polymerase subunit.
Purification of the late transcription system of vaccinia virus: identification of a novel transcription factor.
Recovery of NV knockout infectious hematopoietic necrosis virus expressing foreign genes.
Recruitment of vaccinia virus RNA polymerase to an early gene promoter by the viral early transcription factor.
Regions on the hemagglutinin-neuraminidase proteins of human parainfluenza virus type-1 and Sendai virus important for membrane fusion.
Regulated expression of nuclear genes by T3 RNA polymerase and lac repressor, using recombinant vaccinia virus vectors.
Relationship between RNA polymerase II and efficiency of vaccinia virus replication.
Replication and amplification of defective interfering particle RNAs of vesicular stomatitis virus in cells expressing viral proteins from vectors containing cloned cDNAs.
Replication of hepatitis A viruses with chimeric 5' nontranslated regions.
Requirements for the self-directed replication of flock house virus RNA 1.
Reverse Genetics System for the Avian Coronavirus Infectious Bronchitis Virus.
RNA polymerase activity in purified infectious vaccinia virus.
RNA polymerase III and antiviral innate immune response.
RNA Polymerase Mutations Selected during Experimental Evolution Enhance Replication of a Hybrid Vaccinia Virus with an Intermediate Transcription Factor Subunit Replaced by the Myxoma Virus Ortholog.
RNA polymerase-associated protein Rap94 confers promoter specificity for initiating transcription of vaccinia virus early stage genes.
RNA polymerase-associated transcription specificity factor encoded by vaccinia virus.
Role of forward translocation in nucleoside triphosphate phosphohydrolase I (NPH I)-mediated transcription termination of vaccinia virus early genes.
Sedimentation of an RNA polymerase complex from vaccinia virus that specifically initiates and terminates transcription.
Similarity in genome organization between Molluscum contagiosum virus (MCV) and vaccinia virus (VV): identification of MCV homologues of the VV genes for protein kinase 2, structural protein VP8, RNA polymerase 35 kDa subunit and 3beta-hydroxysteroid dehydrogenase.
Site-specific mutations in vectors that express antigenic and temperature-sensitive phenotypes of the M gene of vesicular stomatitis virus.
Site-specific RNA cleavage generates the 3' end of a poxvirus late mRNA.
Some enzymatic activities associated with purified parapoxvirions.
SP6 RNA polymerase containing vaccinia virus for rapid expression of cloned genes in tissue culture.
Specific initiation of replication at the right-end telomere of the closed species of minute virus of mice replicative-form DNA.
Stability of ternary transcription complexes of vaccinia virus RNA polymerase at promoter-proximal positions.
Stringent chemical and thermal regulation of recombinant gene expression by vaccinia virus vectors in mammalian cells.
Structural analysis of ternary complexes of vaccinia RNA polymerase.
Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes.
Studies on RNA polymerase inhibitor formed in virus-infected cells. 3. Induction of inhibitor of cellular nucleic acid synthesis in vaccinia virus-infected cells.
Synthesis of biologically active influenza virus core proteins using a vaccinia virus-T7 RNA polymerase expression system.
Targeting of a multicomponent transcription apparatus into assembling vaccinia virus particles requires RAP94, an RNA polymerase-associated protein.
Temperature-sensitive mutations in the vaccinia virus H4 gene encoding a component of the virion RNA polymerase.
Ternary complex formation by vaccinia virus RNA polymerase at an early viral promoter: analysis by native gel electrophoresis.
The D1 and D12 subunits are both essential for the transcription termination factor activity of vaccinia virus capping enzyme.
The DI-DII linker of human parainfluenza virus type 3 fusion protein is critical for the virus.
The DNA-dependent ATPase activity of vaccinia virus early gene transcription factor is essential for its transcription activation function.
The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase.
The E7 oncoprotein of human papillomavirus type 16 interacts with F-actin in vitro and in vivo.
The gene (POLR2L) encoding the hRPB7.6 subunit of human RNA polymerase.
The H4 subunit of vaccinia virus RNA polymerase is not required for transcription initiation at a viral late promoter.
The L protein of Rift Valley fever virus can rescue viral ribonucleoproteins and transcribe synthetic genome-like RNA molecules.
The late expression factors 8 and 9 and possibly the phosphoprotein p78/83 of Autographa californica multicapsid nucleopolyhedrovirus are components of the virus-induced RNA polymerase.
The role of vaccinia termination factor and cis-acting elements in vaccinia virus early gene transcription termination.
The small subunit of the vaccinia virus early transcription factor contacts the transcription promoter DNA.
The viral RNA polymerase H4L subunit is required for Vaccinia virus early gene transcription termination.
Tn9 CAT gene contains a promoter for vaccinia virus transcription: implications for reverse-genetic techniques.
trans complementation of cap-independent translation directed by poliovirus 5' noncoding region deletion mutants: evidence for RNA-RNA interactions.
Transcription termination by vaccinia RNA polymerase entails recognition of specific phosphates in the nascent RNA.
Transient expression and sequence of the matrix (M1) gene of WSN influenza A virus in a vaccinia vector.
Translational regulation of Na,K-ATPase alpha1 and beta1 polypeptide expression in epithelial cells.
Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes.
Use of the Capripoxvirus homologue of Vaccinia virus 30kDa RNA polymerase subunit (RPO30) gene as a novel diagnostic and genotyping target: Development of a classical PCR method to differentiate Goat poxvirus from Sheep poxvirus.
UUUUUNU oligonucleotide stimulation of vaccinia virus early gene transcription termination, in trans.
Vaccinia NPH-I, a DExH-box ATPase, is the energy coupling factor for mRNA transcription termination.
Vaccinia virus double-stranded RNA-binding protein E3 does not interfere with siRNA-mediated gene silencing in mammalian cells.
Vaccinia virus early gene transcription termination factors VTF and Rap94 interact with the U9 termination motif in the nascent RNA in a transcription ternary complex.
Vaccinia virus gene D7R encodes a 20,000-dalton subunit of the viral DNA-dependent RNA polymerase.
Vaccinia virus gene encoding a 30-kilodalton subunit of the viral DNA-dependent RNA polymerase.
Vaccinia virus intermediate and late promoter elements are targeted by the TATA-binding protein.
Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and cytoplasmic activation/proliferation-associated protein (p137) individually or as a heterodimer.
Vaccinia virus nonstructural protein encoded by the A11R gene is required for formation of the virion membrane.
Vaccinia virus RNA polymerase associated with nuclei of infected HeLa cells.
Vaccinia virus transcription.
Vaccinia virus-T7 RNA polymerase expression system for neurotransmitter transporters.
Varicella-zoster virus glycoprotein gpI/gpIV receptor: expression, complex formation, and antigenicity within the vaccinia virus-T7 RNA polymerase transfection system.
VP1, the putative RNA-dependent RNA polymerase of infectious bursal disease virus, forms complexes with the capsid protein VP3, leading to efficient encapsidation into virus-like particles.
[Expression of the gene for vaccinia virus 36K nonstructural protein in Escherichia coli and study of the protective properties of expression products]
[Molecular biological study of the vaccinia virus. V. Study of the intracellular localization of the late nonstructural protein 36K]
[The reverse genetics systems for human and animal RNA viruses]
Varicocele
Downregulation of cold-inducible RNA-binding protein activates mitogen-activated protein kinases and impairs spermatogenic function in mouse testes.
Vasculitis
Identification of beta-subunit of bacterial RNA-polymerase--a non-species-specific bacterial protein--as target of antibodies in primary biliary cirrhosis.
Vesicular Stomatitis
5'-terminal sequence of vesicular stomatitis virus mRNA's synthesized in vitro.
A dual-functional priming-capping loop of rhabdoviral RNA polymerases directs terminal de novo initiation and capping intermediate formation.
A freeze frame view of vesicular stomatitis virus transcription defines a minimal length of RNA for 5' processing.
A single amino acid change in the L-polymerase protein of vesicular stomatitis virus completely abolishes viral mRNA cap methylation.
Absence of transcriptase activity or transcription-inhibiting ability in defective interfering particles of vesicular stomatitis virus.
Activation of the virion-associated RNA polymerase of vesicular stomatitis virus by melittin.
Altered ATP function of a vesicular stomatitis virus mutant detected by kinetic analysis of the transcriptase using phosphorylated ribavirin.
An In Vitro RNA Synthesis Assay for Rabies Virus Defines Ribonucleoprotein Interactions Critical for Polymerase Activity.
Analysis of in vitro transcription products of intracellular vesicular stomatitis virus RNA polymerase.
Biochemical Characterization of Respiratory Syncytial Virus RNA-Dependent RNA Polymerase Complex.
Capping of vesicular stomatitis virus pre-mRNA is required for accurate selection of transcription stop-start sites and virus propagation.
Characterization of the phosphorylated small enzyme subunit, NS, of the vesicular stomatitis virus RNA polymerase.
Characterization of vesicular stomatitis virus mRNA species synthesized in vitro.
Complementary Mutations in the N and L Proteins for Restoration of Viral RNA Synthesis.
Complete transcription by the transcriptase of vesicular stomatitis virus.
Coupled in vitro transcription and translation of vesicular stomatitis virus messenger RNA.
Determinants of serotype specificity in transcription of vesicular stomatitis virus synthetic nucleocapsids.
Differential inhibition of vesicular stomatitis virus polypeptide synthesis by hypertonic initiation block.
Display of disparate transcription phenotype by the phosphorylation negative P protein mutants of vesicular stomatitis virus, Indiana serotype, expressed in E. coli and eucaryotic cells.
Dissociation and reconstitution of the transcriptase and template activities of vesicular stomatitis B and T virions.
Dissociation of vesicular stomatitis virus and relation of the virion proteins to the viral transcriptase.
Effect of temperature-sensitive mutation on activity of the RNA transcriptase of vesicular stomatitis virus New Jersey.
Effect of temperature-sensitive mutations on the virion-associated RNA transcriptase of vesicular stomatitis virus.
Efficient Production of Human Norovirus-Specific IgY in Egg Yolks by Vaccination of Hens with a Recombinant Vesicular Stomatitis Virus Expressing VP1 Protein.
Expression of a cDNA encoding a functional 241-kilodalton vesicular stomatitis virus RNA polymerase.
Expression of L protein of vesicular stomatitis virus Indiana serotype from recombinant baculovirus in insect cells: requirement of a host factor(s) for its biological activity in vitro.
Faithful and efficient in vitro reconstitution of vesicular stomatitis virus transcription using plasmid-encoded L and P proteins.
Formation of guanosine(5')tetraphospho(5')adenosine cap structure by an unconventional mRNA capping enzyme of vesicular stomatitis virus.
Function and structure of RNA polymerase from vesicular stomatitis virus.
Histidine-mediated RNA transfer to GDP for unique mRNA capping by vesicular stomatitis virus RNA polymerase.
Host range mutants of vesicular stomatitis virus defective in in vitro RNA methylation.
Identification of a domain within the phosphoprotein of vesicular stomatitis virus that is essential for transcription in vitro.
Identification of a set of proteins (C' and C) encoded by the bicistronic P gene of the Indiana serotype of vesicular stomatitis virus and analysis of their effect on transcription by the viral RNA polymerase.
In vitro capping and transcription of rhabdoviruses.
In vitro inhibition of negative strand virus transcriptase activity by proteins soluble in acidic chloroform-methanol.
In vitro RNA transcription by the New Jersey serotype of vesicular stomatitis virus. I. Characterization of the mRNA species.
In vitro synthesis of genome length complementary RNA of vesicular stomatitis virus in the presence of inosine 5'-triphosphate.
In vitro synthesis of messenger RNA by a defective interfering particle of vesicular stomatitis virus.
In vitro synthesis of methylated messenger RNA by the virion-associated RNA polymerase of vesicular stomatitis virus.
In vitro synthesis of RNA that contains polyadenylate by virion-associated RNA polymerase of vesicular stomatitis virus.
In vitro synthesis of the full-length complement of the negative-strand genome RNA of vesicular stomatitis virus.
In vitro transcriptase activity of vesicular stomatitis virus B and T particles: analysis of product.
Inactivation of influenza and vesicular stomatitis virion RNA polymerase activities by photoreaction with 4'-substituted psoralens.
Inactivation of the RNA polymerase of vesicular stomatitis virus by N-ethylmaleimide and protection by nucleoside triphosphates. Evidence for a second ATP binding site on L protein.
Inhibition by aurintricarboxylic acid and polyethylene sulfonate of RNA transcription of vesicular stomatitis virus.
Inhibition of host RNA polymerase II-dependent transcription by vesicular stomatitis virus results from inactivation of TFIID.
Inhibition of the RNA polymerase of vesicular stomatitis virus by ppp5'A2'p5'A and related compounds.
Inhibition of vesicular stomatitis virus in cells constitutively expressing an antisense RNA targeted against the virus RNA polymerase gene.
Inhibition of vesicular stomatitis virus transcriptase complex by the virion envelope M protein.
Inhibition of vesicular stomatitis virus transcriptase in vitro by phosphonoformate and ara-ATP.
Inhibition of viral transcriptase by immunoglobulin directed against the nucleocapsid NS protein of vesicular stomatitis virus.
Inhibitor of vesicular stomatitis virus transcriptase in purified virions.
Initiation and direction of RNA transcription by vesicular stomatitis virus virion transcriptase.
Initiation of RNA synthesis in vitro by vesicular stomatitis virus. Role of ATP.
Interaction of L and NS proteins of vesicular stomatitis virus with its template ribonucleoprotein during RNA synthesis in vitro.
Interaction of wild-type and mutant M protein vesicular stomatitis virus with nucleocapsids in vitro.
Interferon treatment inhibits glycosylation of a viral protein.
Isolation of an infectious ribonucleoprotein from vesicular stomatitis virus containing an active RNA transcriptase.
Lack of evidence for proofreading mechanisms associated with an RNA virus polymerase.
Location of the binding domains for the RNA polymerase L and the ribonucleocapsid template within different halves of the NS phosphoprotein of vesicular stomatitis virus.
Mapping and functional role of the self-association domain of vesicular stomatitis virus phosphoprotein.
Messenger RNA species synthesized in vitro by the virion-associated RNA polymerase of vesicular stomatitis virus.
Molecular architecture of the vesicular stomatitis virus RNA polymerase.
Newly identified phosphorylation site in the vesicular stomatitis virus P protein is required for viral RNA synthesis.
NH2-terminal acidic region of the phosphoprotein of vesicular stomatitis virus can be functionally replaced by tubulin.
Norwalk virus nonstructural protein p48 forms a complex with the SNARE regulator VAP-A and prevents cell surface expression of vesicular stomatitis virus G protein.
Novel binding of GTP to the phosphoprotein (P) of vesicular stomatitis virus.
Optimal replication activity of vesicular stomatitis virus RNA polymerase requires phosphorylation of a residue(s) at carboxy-terminal domain II of its accessory subunit, phosphoprotein P.
Persistent noncytocidal vesicular stomatitis virus infections mediated by defective T particles that suppress virion transcriptase.
Phenotypic revertants of temperature-sensitive M protein mutants of vesicular stomatitis virus: sequence analysis and functional characterization.
Phosphorylation of NS protein by vesicular stomatitis virus nucleocapsids: lack of effect during RNA synthesis and separation of kinase from L protein.
Phosphorylation of specific serine residues within the acidic domain of the phosphoprotein of vesicular stomatitis virus regulates transcription in vitro.
Phosphorylation of vesicular stomatitis virus phosphoprotein P is indispensable for virus growth.
Phosphorylation within the amino-terminal acidic domain I of the phosphoprotein of vesicular stomatitis virus is required for transcription but not for replication.
Production of vesicular stomatitis virus with low infectivity by interferon-treated cells.
Promoter analysis of the vesicular stomatitis virus RNA polymerase.
Protamine--a potent inhibitor of vesicular stomatitis virus transcriptase in vitro.
Rebinding of transcriptase components (L and NS proteins) to the nucleocapsid template of vesicular stomatitis virus.
Reconstitution of infectivity and transcriptase activity of homologous and heterologous viruses: vesicular stomatitis (Indiana serotype), Chandipura, vesicular stomatitis (New Jersey serotype), and Cocal viruses.
Reconstitution studies detect a single polymerase entry site on the vesicular stomatitis virus genome.
Regulation of RNA synthesis by the genomic termini of vesicular stomatitis virus: identification of distinct sequences essential for transcription but not replication.
Replication and transcription of viral RNAs by recombinant L proteins of New Jersey serotype of vesicular stomatitis virus.
Reversal by certain polyanions of an endogenous inhibitor of the vesicular stomatitis virus-associated transcriptase.
Revertants of a mutant of vesicular stomatitis virus which has an aberrant polyadenylation activity and a temperature-sensitive transcriptase.
Rhabdoviridae. Report of the Rhabdovirus Study Group, International Committee on Taxonomy of Viruses.
Ribonucleic acid synthesis of vesicular stomatitis virus, II. An RNA polymerase in the virion.
RNA polymerase activity and poly(A) synthesizing activity in defective T particles of vesicular stomatitis virus.
RNA polymerase of vesicular stomatitis virus specifically associates with translation elongation factor-1 alphabetagamma for its activity.
RNA polymerase-associated interactions near template promoter sequences of defective interfering particles of vesicular stomatitis virus.
RNA- temperature-sensitive mutants of vesicular stomatitis virus: L-protein thermosensitivity accounts for transcriptase restriction of group I mutants.
Role of cellular casein kinase II in the function of the phosphoprotein (P) subunit of RNA polymerase of vesicular stomatitis virus.
Role of the hypervariable hinge region of phosphoprotein P of vesicular stomatitis virus in viral RNA synthesis and assembly of infectious virus particles.
Role of the membrane (M) protein in endogenous inhibition of in vitro transcription by vesicular stomatitis virus.
Sequence of a RNA templated by the 3'-OH RNA terminus of defective interfering particles of vesicular stomatitis virus.
Sequence-specific contacts between the RNA polymerase of vesicular stomatitis virus and the leader RNA gene.
Sequential phosphorylation of the phosphoprotein of vesicular stomatitis virus by cellular and viral protein kinases is essential for transcription activation.
Site of synthesis of membrane and nonmembrane proteins of vesicular stomatitis virus.
Solution structure of the C-terminal nucleoprotein-RNA binding domain of the vesicular stomatitis virus phosphoprotein.
Specific interaction of heterogeneous nuclear ribonucleoprotein particle U with the leader RNA sequence of vesicular stomatitis virus.
Spring viremia of carp virus RNA and virion-associated transcriptase activity.
Stabilization of vesicular stomatitis virus L polymerase protein by P protein binding: a small deletion in the C-terminal domain of L abrogates binding.
Stimulation of vesicular stomatitis virus in vitro RNA synthesis by microtubule-associated proteins.
Structure and Function of the N-Terminal Domain of the Vesicular Stomatitis Virus RNA Polymerase.
Structure and function of the RNA polymerase of vesicular stomatitis virus.
Temperature sensitivity of the transcriptase of mutants tsB1 and tsF1 of vesicular stomatitis virus New Jersey is a consequence of mutation affecting polypeptide L.
Temperature-dependent host range mutation in vesicular stomatitis virus affecting polypeptide L.
Temperature-sensitive mutants of vesicular stomatitis virus: comparison of the in vitro RNA polymerase defects of group I and group IV mutants.
Temperature-sensitive mutants of vesicular stomatitis virus: viral RNA synthesis in cells infected with mutants belonging to complementation group I.
The 5' terminal structure of the methylated mRNA synthesized in vitro by vesicular stomatitis virus.
The complete sequence of a unique RNA species synthesized by a DI particle of VSV.
The cost of replication fidelity in an RNA virus.
The Discovery of Reverse Transcriptase.
The L protein of vesicular stomatitis virus transcription complexes is specifically photolabelled by 5-azido-uridine 5'-triphosphate, an analogue of the RNA polymerase substrate uridine 5'-triphosphate.
The Methyltransferase Region of Vesicular Stomatitis Virus L Polymerase Is a Target Site for Functional Intramolecular Insertion.
The role of polypeptides L and NS in the transcription process of vesicular stomatitis virus New Jersey using the temperature-sensitive mutant tsE1.
Transcriptase activity associated with rabies virion.
Transcriptional activity and mutational analysis of recombinant vesicular stomatitis virus RNA polymerase.
Transcriptional control of the RNA-dependent RNA polymerase of vesicular stomatitis virus.
Translation and identification of the mRNA species synthesized in vitro by the virion-associated RNA polymerase of vesicular stomatitis virus.
Two methyltransferase activities in the purified virions of vesicular stomatitis virus.
Two RNA polymerase complexes from vesicular stomatitis virus-infected cells that carry out transcription and replication of genome RNA.
Two separate domains within vesicular stomatitis virus phosphoprotein support transcription when added in trans.
Unconventional mechanism of mRNA capping by the RNA-dependent RNA polymerase of vesicular stomatitis virus.
Unique capping activity of the recombinant RNA polymerase (L) of vesicular stomatitis virus: association of cellular capping enzyme with the L protein.
Use of a hybrid infectivity assay to analyze primary transcription of temperature-sensitive mutants of the New Jersey serotype of vesicular stomatitis virus.
Vesicular stomatitis virion-associated transcriptase activity was suppressed in vitro by a synthetic 21 amino acid oligopeptide prepared to mimic the carboxy-terminus of NS protein.
Vesicular Stomatitis Virus and DNA Vaccines Expressing Zika Virus Nonstructural Protein 1 Induce Substantial but Not Sterilizing Protection against Zika Virus Infection.
Vesicular stomatitis virus mutants resistant to defective-interfering particles accumulate stable 5'-terminal and fewer 3'-terminal mutations in a stepwise manner.
Vesicular stomatitis virus RNA polymerase can read through the boundary between the leader and N genes in vitro.
Vesicular stomatitis virus-based vaccines expressing EV71 virus-like particles elicit strong immune responses and protect newborn mice from lethal challenges.
Vesicular stomatitis virus: mode of transcription.
Visualization of intracellular transport of vesicular stomatitis virus nucleocapsids in living cells.
[RNA polymerase in virions of vesicular stomatitis virus (author's transl)]
Viremia
5'-Terminal Sequences of Spring Viremia of Carp Virus RNA Synthesized In Vitro.
Alpha interferon is a powerful adjuvant for a recombinant protein vaccine against foot-and-mouth disease virus in swine, and an effective stimulus of in vivo immune response.
An Evidence-Based Algorithm for Early Prognosis of Severe Dengue in the Outpatient Setting.
Antibody responses in parvovirus B19 infected patients.
Assessment of hepatitis C virus RNA levels by quantitative competitive RNA polymerase chain reaction: high-titer viremia correlates with advanced stage of disease.
Determination of viremia and concentration of circulating nonstructural protein 1 in patients infected with dengue virus in Mexico.
Do statins reduce hepatitis C RNA titers during routine clinical use?
Effects of Short-Course Oral Corticosteroid Therapy in Early Dengue Infection in Vietnamese Patients: A Randomized, Placebo-Controlled Trial.
Enhanced detection of antibodies to hepatitis C virus by use of a third-generation recombinant immunoblot assay.
In-vitro inhibition of spring viremia of carp virus replication by RNA interference targeting the RNA-dependent RNA polymerase gene.
Kinetics of plasma viremia and soluble nonstructural protein 1 concentrations in dengue: differential effects according to serotype and immune status.
Nonstructural protein NS1 immunodominant epitope detected specifically in dengue virus infected material by a SELDI-TOF/MS based assay.
NS1 Antigenemia and Viraemia Load: Potential Markers of Progression to Dengue Fatal Outcome?
Persistent hepatitis C virus infection after liver transplantation: clinical and virological features.
Polymorphisms of NS5B protein relates to early clearance of hepatitis C virus by interferon plus ribavirin: a pilot study.
Protection against yellow fever in monkeys by immunization with yellow fever virus nonstructural protein NS1.
Reliability of the third-generation recombinant immunoblot assay for hepatitis C virus.
Remdesivir failure with SARS-CoV-2 RNA-dependent RNA-polymerase mutation in a B-cell immunodeficient patient with protracted Covid-19.
Reovirus nonstructural protein sigma1s is required for establishment of viremia and systemic dissemination.
Safety and efficacy of lamivudine-zidovudine combination therapy in antiretroviral-naive patients. A randomized controlled comparison with zidovudine monotherapy. Lamivudine European HIV Working Group.
Spring viremia of carp virus RNA and virion-associated transcriptase activity.
Synthesis of capped and uncapped methylated oligonucleotides by the virion transcriptase of spring viremia of carp virus, a rhabdovirus.
Systemic Expression of a Viral RdRP Protects Against Retrovirus Infection and Disease.
The effect of freeze-dried Carica papaya leaf juice treatment on NS1 and viremia levels in dengue fever mice model.
Virus Diseases
"Inapparent" hepatitis B virus infection and hepatitis C virus replication in alcoholic subjects with and without liver disease.
A glycine-rich RNA-binding protein gene is differentially expressed during acute hypersensitive response following Tobacco Mosaic Virus infection in tobacco.
A novel role for RAX, the cellular activator of PKR, in synergistically stimulating SV40 large T antigen-dependent gene expression.
A recombinant foot-and-mouth disease virus antigen inhibits DNA replication and triggers the SOS response in Escherichia coli.
A tobacco CBL-interacting protein kinase homolog is involved in phosphorylation of the N-terminal domain of the cucumber mosaic virus polymerase 2a protein.
Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and viral persistence.
An important role of an inducible RNA-dependent RNA polymerase in plant antiviral defense.
Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach.
Analysis of the involvement of an inducible Arabidopsis RNA-dependent RNA polymerase in antiviral defense.
Anti-influenza activity of c60 fullerene derivatives.
Antiviral effects of single-stranded polynucleotide inhibitors of the influenza virion-associated transcriptase against influenza virus infection of hamsters and ferrets.
Approved Antiviral Drugs over the Past 50 Years.
Arabidopsis RNA-dependent RNA polymerases and dicer-like proteins in antiviral defense and small interfering RNA biogenesis during Turnip Mosaic Virus infection.
Beclin1 restricts RNA virus infection in plants through suppression and degradation of the viral polymerase.
Betanodavirus B2 is an RNA interference antagonist that facilitates intracellular viral RNA accumulation.
Bovine viral diarrhea virus nonstructural protein 5A interacts with NIK and IKK{beta}-binding protein (NIBP).
Characterization of soluble RNA-dependent RNA polymerase from dengue virus serotype 2: The polyhistidine tag compromises the polymerase activity.
Characterization of the stimulators of protein-directed ribosomal frameshifting in Theiler's murine encephalomyelitis virus.
Classical Swine Fever Virus p7 Protein Interacts with Host Protein CAMLG and Regulates Calcium Permeability at the Endoplasmic Reticulum.
Clinical Pharmacokinetics and Pharmacodynamics of Ledipasvir/Sofosbuvir, a Fixed-Dose Combination Tablet for the Treatment of Hepatitis C.
Combination of Nonstructural Protein 1-Based Enzyme-Linked Immunosorbent Assays Can Detect and Distinguish Various Dengue Virus and Zika Virus Infections.
Combinations of favipiravir and peramivir for the treatment of pandemic influenza A/California/04/2009 (H1N1) virus infections in mice.
Comparative Evaluation of Tears and Nasopharyngeal Swab for SARS-CoV-2 in COVID-19 Dedicated Intensive Care Unit Patients.
Comparative studies on ribonucleic acid dependent RNA polymerases in cucumber mosaic virus infected cucumber and tobacco and uninfected tobacco plants.
Comparison of capture immunoglobulin M (IgM) and IgG enzyme-linked immunosorbent assay (ELISA) and nonstructural protein NS1 serotype-specific IgG ELISA for differentiation of primary and secondary dengue virus infections.
Correction. Arabidopsis RNA-dependent RNA polymerases and dicer-like proteins in antiviral defense and small interfering RNA biogenesis during Turnip mosaic virus infection.
Current approaches for target-specific drug discovery using natural compounds against SARS-CoV-2 infection.
Cytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by entering the nucleus and interfering with Prp8.
Dengue virus nonstructural protein 1 is expressed in a glycosyl-phosphatidylinositol-linked form that is capable of signal transduction.
Detection of antibodies specific for foot-and-mouth disease virus infection using indirect ELISA based on recombinant nonstructural protein 2B.
Detection of dengue virus nonstructural protein 1 (NS1) by using ELISA as a useful laboratory diagnostic method for dengue virus infection of international travelers.
Detection of Dengue Virus Nonstructural Protein 1 (NS1) in Urine Samples using ELISA as a Laboratory Diagnostic Method for Dengue Virus Infection.
Detection of hepatitis C virus NS5 protein and genome in Chinese carcinoma of the extrahepatic bile duct and its significance.
Detection of HIV-1 provirus and RNA by in situ amplification.
Determination of Etiology and Epidemiology of Viral Central Nervous System Infections by Quantitative Real-Time Polymerase Chain Reaction in Central India Population.
Development of IFN-Stimulated Gene Expression from Embryogenesis through Adulthood, with and without Constitutive MDA5 Pathway Activation.
Diagnostic approach for differentiating infected from vaccinated poultry on the basis of antibodies to NS1, the nonstructural protein of influenza A virus.
Diagnostic potential of recombinant nonstructural protein 3B to detect antibodies induced by foot-and-mouth disease virus infection in bovines.
Differential inductions of RNA silencing among encapsidated double-stranded RNA mycoviruses in the white root rot fungus, Rosellinia necatrix.
Distribution and dynamics of transcription-associated proteins during parvovirus infection.
Distribution of lignin-carbohydrate complex in plant kingdom and its functionality as alternative medicine.
Distribution of naturally -occurring NS5B resistance-associated substitutions in Egyptian patients with chronic Hepatitis C.
Domestic dengue infection with hemophagocytic lymphohistiocytosis successfully treated by early steroid therapy.
Drug-Drug Interaction Profile of the Fixed-Dose Combination Tablet Regimen Ledipasvir/Sofosbuvir.
DWV Infection in vitro Using Honey Bee Pupal Tissue.
eEF1G interaction with foot-and-mouth disease virus nonstructural protein 2B: Identification by yeast two-hybrid system.
Emetine, a potent alkaloid for the treatment of SARS-CoV-2 targeting papain-like protease and non-structural proteins: pharmacokinetics, molecular docking and dynamic studies.
Engineering partial resistance to cucumber mosaic virus in tobacco using intrabodies specific for the viral polymerase.
Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism.
Entry of sapelovirus into IPEC-J2 cells is dependent on caveolae-mediated endocytosis.
Establishment of an immunoscreening system using recombinant VP1 protein for the isolation of a monoclonal antibody that blocks JC virus infection.
Ethanolic Extract of Melia Fructus Has Anti-influenza A Virus Activity by Affecting Viral Entry and Viral RNA Polymerase.
Expression of the dengue virus type 2 NS5 protein in a CD4(+) T cell line inhibits HIV replication.
Flaviviridae virus nonstructural proteins 5 and 5A mediate viral immune evasion and are promising targets in drug development.
Flavivirus NS1 Triggers Tissue-Specific Vascular Endothelial Dysfunction Reflecting Disease Tropism.
Generation of mutant Uukuniemi viruses lacking the nonstructural protein NSs by reverse genetics indicates that NSs is a weak interferon antagonist.
Genome-wide identification of Dicer-like, Argonaute and RNA-dependent RNA polymerase gene families and their expression analyses in response to viral infection and abiotic stresses in Solanum lycopersicum.
Hepatitis C Virus NS5A Targets Nucleosome Assembly Protein NAP1L1 To Control the Innate Cellular Response.
High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever.
High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity.
Highlights in the development of new antiviral agents.
Human microRNA hsa-miR-15b-5p targets the RNA template component of the RNA-dependent RNA polymerase structure in severe acute respiratory syndrome coronavirus 2.
Identification and characterization of a baboon reovirus-specific nonstructural protein encoded by the bicistronic s4 genome segment.
Identification, sequence, and expression of the gene encoding a Mr 35,000 subunit of the vaccinia virus DNA-dependent RNA polymerase.
Immune response to a hepatitis C virus nonstructural protein in chronic hepatitis C virus infection.
Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus vaccination.
Immunogenic characterization and epitope mapping of transmissible gastroenteritis virus RNA dependent RNA polymerase.
Improved immunogenicity of a peptide epitope after fusion to hepatitis B core protein.
Improving dengue viral antigens detection in dengue patient serum specimens using a low pH glycine buffer treatment.
Indirect ELISA using recombinant nonstructural protein 3D to detect foot and mouth disease virus infection associated antibodies.
Inducible CYP4F12 enhances Hepatitis C virus infection via association with viral nonstructural protein 5B.
Infection-Induced Retrotransposon-Derived Noncoding RNAs Enhance Herpesviral Gene Expression via the NF-?B Pathway.
Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses.
Influenza Virus Infection Induces Host Pyruvate Kinase M Which Interacts with Viral RNA-Dependent RNA Polymerase.
Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention.
Insights into RNA-dependent RNA Polymerase Inhibitors as Anti-influenza Virus Agents.
Interaction between hantavirus nucleocapsid protein (N) and RNA-dependent RNA polymerase (RdRp) mutants reveals the requirement of an N-RdRp interaction for viral RNA synthesis.
Interactome Analysis of NS1 Protein Encoded by Influenza A H7N9 Virus Reveals an Inhibitory Role of NS1 in Host mRNA Maturation.
Interference with viral infection by defective RNA replicase.
Interference with viral infection by RNA replicase deleted at the carboxy-terminal region.
Lignified materials as potential medicinal resources. III. Diversity of biological activity and possible molecular species involved.
Marine Oomycetes of the Genus Halophytophthora Harbor Viruses Related to Bunyaviruses.
Mechanistic Aspects of Medicinal Plants and Secondary Metabolites against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VIII. Pathological consequences of rotavirus infection and its enterotoxin.
MicroRNA-146a promotes red spotted grouper nervous necrosis virus (RGNNV) replication by targeting TRAF6 in orange spotted grouper, Epinephelus coioides.
Mink Enteritis Virus Infection Induces Mitochondrion-mediated Apoptosis by the Viral Nonstructural Protein 1.
miRNA-200c-3p is crucial in acute respiratory distress syndrome.
Modification of RNA polymerase IIO subspecies after poliovirus infection.
Monoclonal antibodies against foot-and-mouth disease virus RNA polymerase for detection of virus infection.
Mutational analysis of Rift Valley fever phlebovirus nucleocapsid protein indicates novel conserved, functional amino acids.
Natural history of GBV-C/hepatitis G virus infection through the follow-up of GBV-C/hepatitis G virus-infected blood donors and recipients studied by RNA polymerase chain reaction and anti-E2 serology.
Nonstructural protein 1 antibody-based epitope-blocking enzyme-linked immunosorbent assay to differentiate Japanese encephalitis virus from dengue virus infections in humans.
Nonstructural protein NS4 of Rice Stripe Virus plays a critical role in viral spread in the body of vector insects.
Nonstructural Protein NSs Hampers Cellular Antiviral Response through LSm14A during Severe Fever with Thrombocytopenia Syndrome Virus Infection.
Nonstructural protein of infectious bursal disease virus inhibits apoptosis at the early stage of virus infection.
Nonstructural protein Pns12 of rice dwarf virus is a principal regulator for viral replication and infection in its insect vector.
Nonstructural protein Pns4 of rice dwarf virus is essential for viral infection in its insect vector.
Novel guanosine derivatives against Zika virus polymerase in silico.
NP and NS1 proteins of H5N1 virus significantly upregulated IFITM1, IFITM2, and IFITM3 in A549 cells.
NS5B RNA Dependent RNA Polymerase Inhibitors: The Promising Approach to Treat Hepatitis C Virus Infections.
Nuclear localization of dengue virus nonstructural protein 5 through its importin alpha/beta-recognized nuclear localization sequences is integral to viral infection.
Nucleolin Promotes IRES-Driven Translation of Foot-and-Mouth Disease Virus by Supporting the Assembly of Translation Initiation Complexes.
Optimizing choice of oral interferon-free treatment for genotype 1 hepatitis C virus using testing for NS5A resistance: a cost-utility analysis from the perspective of the Italian National Health Service.
Persistent noncytocidal vesicular stomatitis virus infections mediated by defective T particles that suppress virion transcriptase.
Phenotypic characterization of mutants in vaccinia virus gene G2R, a putative transcription elongation factor.
Phosphorylation of cucumber mosaic virus RNA polymerase 2a protein inhibits formation of replicase complex.
Phosphorylation of the viral nonstructural protein NS1 during MVMp infection of A9 cells.
Phosphorylation of viral RNA-dependent RNA polymerase and its role in replication of a plus-strand RNA virus.
Posttranscriptional Control of Type I Interferon Genes by KSRP in the Innate Immune Response against Viral Infection.
Potent host-directed small-molecule inhibitors of myxovirus RNA-dependent RNA-polymerases.
Potential application of nonstructural protein NS1 serotype-specific immunoglobulin G enzyme-linked immunosorbent assay in the seroepidemiologic study of dengue virus infection: correlation of results with those of the plaque reduction neutralization test.
Potential Phosphorylation of Viral Nonstructural Protein 1 in Dengue Virus Infection.
Protection against Dengue Virus Infection in Mice by Administration of Antibodies against Modified Nonstructural Protein 1.
Proteomic analyses identify intracellular targets for Japanese encephalitis virus nonstructural protein 1 (NS1).
Re-evaluation of the pathogenic roles of nonstructural protein 1 and its antibodies during dengue virus infection.
Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection.
Recent advances in the discovery of potent RNA-dependent RNA-polymerase (RdRp) inhibitors targeting viruses.
Recombinant virus like particles as drug delivery system.
Recombinant VP1 protein as a potential marker for the diagnosis of acute hepatitis A virus infection.
Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites.
Resistance to Plum pox virus in plants expressing cytosolic and nuclear single?chain antibodies against the viral RNA NIb replicase
Reversal of nonstructural protein 3-specific CD4(+) T cell dysfunction in patients with persistent hepatitis C virus infection.
Review article: the efficacy and safety of sofosbuvir, a novel, oral nucleotide NS5B polymerase inhibitor, in the treatment of chronic hepatitis C virus infection.
RNA dependent RNA polymerase activity associated with the double-stranded RNA virus of Giardia lamblia.
RNA-Dependent RNA Polymerase 1 from Nicotiana tabacum Suppresses RNA Silencing and Enhances Viral Infection in Nicotiana benthamiana.
RNA-dependent RNA polymerase of tobacco plants.
Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review).
Role of cellular RNA polymerases in virus-induced leukemogenesis.
Roles of nonstructural protein nsP2 and Alpha/Beta interferons in determining the outcome of Sindbis virus infection.
Salicylic acid treatment and expression of an RNA-dependent RNA polymerase 1 transgene inhibit lethal symptoms and meristem invasion during tobacco mosaic virus infection in Nicotiana benthamiana.
SAR study of bisamides as cyclophilin a inhibitors for the development of host-targeting therapy for hepatitis C virus infection.
SCE1, the SUMO-Conjugating Enzyme in Plants That Interacts with NIb, the RNA-Dependent RNA Polymerase of Turnip Mosaic Virus, Is Required for Viral Infection.
Serologic Prevalence of MPV1 in Mouse Strains in a Commercial Laboratory Mouse Colony Determined by Using VP1 Antigen.
Serotype 1-specific monoclonal antibody-based antigen capture immunoassay for detection of circulating nonstructural protein NS1: Implications for early diagnosis and serotyping of dengue virus infections.
Sofosbuvir as a potential alternative to treat the SARS-CoV-2 epidemic.
Structural Decoding of a Small Molecular Inhibitor on the Binding of SARS-CoV-2 to the ACE 2 Receptor.
Structure of nonstructural protein 1 from SARS-CoV-2.
Structure of Nonstructural Protein 1 from SARS-CoV-2.
Studies of the Interaction of Influenza Virus RNA Polymerase PAN with Endonuclease Inhibitors.
Sumoylation of Turnip mosaic virus RNA polymerase promotes viral infection by counteracting the host NPR1-mediated immune response.
Sumoylation-promoted enterovirus 71 3C degradation correlates with a reduction in viral replication and cell apoptosis.
Temperature Sensitive Mutations in Influenza A Viral Ribonucleoprotein Complex Responsible for the Attenuation of the Live Attenuated Influenza Vaccine.
The effects of autophagy on the replication of Nelson Bay orthoreovirus.
The Potyvirus Silencing Suppressor Protein VPg Mediates Degradation of SGS3 via Ubiquitination and Autophagy Pathways.
The prevalence of enteroviral RNA and protein in mitral valves of chronic rheumatic heart disease.
The RNA-Dependent RNA Polymerase NIb of Potyviruses Plays Multifunctional, Contrasting Roles during Viral Infection.
The RNA-dependent RNA polymerase of cowpea is not involved in cowpea mosaic virus RNA replication: immunological evidence.
The role of the influenza virus RNA polymerase in host shut-off.
The ubiquitin-proteasome system regulates the accumulation of Turnip yellow mosaic virus RNA-dependent RNA polymerase during viral infection.
The Whys and Wherefores of Transitivity in Plants.
Theiler's virus infection induces a predominant pathogenic CD4+ T cell response to RNA polymerase in susceptible SJL/J mice.
Tobacco RNA-dependent RNA polymerase 1 affects the expression of defence-related genes in Nicotiana benthamiana upon Tomato leaf curl Gujarat virus infection.
Topical Application of Escherichia coli-Encapsulated dsRNA Induces Resistance in Nicotiana benthamiana to Potato Viruses and Involves RDR6 and Combined Activities of DCL2 and DCL4.
Transgenic Expression of the 3D Polymerase Inhibits Theiler's Virus Infection and Demyelination.
Use of Urea Wash ELISA to Distinguish Zika and Dengue Virus Infections.
Viral RNA-dependent RNA polymerase inhibitor 7-deaza-2'-C-methyladenosine prevents death in a mouse model of West Nile virus infection.
Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts.
Viral Transcription During Autographa californica Nuclear Polyhedrosis Virus Infection: a Novel RNA Polymerase Induced in Infected Spodoptera frugiperda Cells.
Viroinformatics-Based Analysis of SARS-CoV-2 Core Proteins for Potential Therapeutic Targets.
VX-222, a non-nucleoside NS5B polymerase inhibitor, in telaprevir-based regimens for genotype 1 hepatitis C virus infection.
Worldwide distribution of the NS3 gene 80K polymorphism among circulating hepatitis C genotype 1 viruses: implication for simeprevir usage.
[Competitive evolution of enzymatic activities of the transcriptase and replicase type during a viral disease in cattle]
[Marburg and Ebola hemorrhagic fevers--pathogens, epidemiology and therapy].
Vision Disorders
Congenital Visual Impairment and Progressive Microcephaly Due to Lysyl-Transfer Ribonucleic Acid (RNA) Synthetase (KARS) Mutations: The Expanding Phenotype of Aminoacyl-Transfer RNA Synthetase Mutations in Human Disease.
Vitamin B 6 Deficiency
Vitamin B6 deficiency causes activation of RNA polymerase and general enhancement of gene expression in rat liver.
Warts
Approved Antiviral Drugs over the Past 50 Years.
Werner Syndrome
Roles of RNase P and Its Subunits.
West Nile Fever
Immunoassay targeting nonstructural protein 5 to differentiate West Nile virus infection from dengue and St. Louis encephalitis virus infections and from flavivirus vaccination.
New avenues for therapeutic discovery against West Nile virus.
Persistence of antibodies to West Nile virus nonstructural protein 5.
Viral RNA-dependent RNA polymerase inhibitor 7-deaza-2'-C-methyladenosine prevents death in a mouse model of West Nile virus infection.
Whooping Cough
A Mutation Upstream of the rplN-rpsD Ribosomal Operon Downregulates Bordetella pertussis Virulence Factor Production without Compromising Bacterial Survival within Human Macrophages.
A new gene locus of Bordetella pertussis defines a novel family of prokaryotic transcriptional accessory proteins.
Bordetella pertussis fim3 gene regulation by BvgA: Phosphorylation controls the formation of inactive vs. active transcription complexes.
Differential binding of BvgA to two classes of virulence genes of Bordetella pertussis directs promoter selectivity by RNA polymerase.
Effect of mutations causing overexpression of RNA polymerase alpha subunit on regulation of virulence factors in Bordetella pertussis.
Mutations affecting the alpha subunit of Bordetella pertussis RNA polymerase suppress growth inhibition conferred by short C-terminal deletions of the response regulator BvgA.
Nature of DNA binding and RNA polymerase interaction of the Bordetella pertussis BvgA transcriptional activator at the fha promoter.
Overexpression of the RNA polymerase alpha subunit reduces transcription of Bvg-activated virulence genes in Bordetella pertussis.
Synergistic binding of RNA polymerase and BvgA phosphate to the pertussis toxin promoter of Bordetella pertussis.
The Bordetella pertussis model of exquisite gene control by the global transcription factor BvgA.
The Bordetella pertussis sigma subunit of RNA polymerase confers enhanced expression of fha in Escherichia coli.
Wilms Tumor
Genomic characterization of Wilms' tumor suppressor 1 targets in nephron progenitor cells during kidney development.
Wiskott-Aldrich Syndrome
A novel role of the actin-nucleating Arp2/3 complex in the regulation of RNA polymerase II-dependent transcription.
Mutations of RNA polymerase II activate key genes of the nucleoside triphosphate biosynthetic pathways.
Wolf-Hirschhorn Syndrome
Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA.
Wound Infection
Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus-Based Wound Infection Model in SKH1 Mice.
Xeroderma Pigmentosum
Adenovirus type 12-induced fragility of the human RNU2 locus requires p53 function.
Yellow Fever
Beyond Members of the Flaviviridae Family, Sofosbuvir Also Inhibits Chikungunya Virus Replication.
Fluorescent tagging the NS1 protein in yellow fever virus: Replication-capable viruses which produce the secretory GFP-NS1 fusion protein.
Genetic interaction of flavivirus nonstructural proteins NS1 and NS4A as a determinant of replicase function.
Glycosylation and secretion of yellow fever virus nonstructural protein NS1.
High fidelity of yellow fever virus RNA polymerase.
Identification of three H-2K(d) restricted CTL epitopes of NS4A and NS4B protein from Yellow fever 17D vaccine.
Mutation in NS5 protein attenuates mouse neurovirulence of yellow fever 17D vaccine virus.
Mutation of critical residues reveals insights of yellow fever virus nonstructural protein 1 (NS1) stability and its formation.
Mutations in the yellow fever virus nonstructural protein NS2A selectively block production of infectious particles.
Protection against yellow fever in monkeys by immunization with yellow fever virus nonstructural protein NS1.
Repositioning of RdRp Inhibitors against HCV NS5B Polymerase Utilizing Structure-Based Molecular Docking.
Repurposing Old Antibodies for New Diseases by Exploiting Cross-Reactivity and Multicolored Nanoparticles.
Structural and Nonstructural Genes Contribute to the Genetic Diversity of RNA Viruses.
Structure of the yellow fever NS5 protein reveals conserved drug targets shared among flaviviruses.
The eukaryotic translation initiation factor 3 subunit L protein interacts with Flavivirus NS5 and may modulate yellow fever virus replication.
The interferon signaling antagonist function of yellow fever virus NS5 protein is activated by type I interferon.
The nucleotide sequence of dengue type 4 virus: analysis of genes coding for nonstructural proteins.
The Role of NS5 Protein in Determination of Host Cell Range for Yellow Fever Virus.
The small nuclear ribonucleoprotein U1A interacts with NS5 from yellow fever virus.
trans-Complementation of yellow fever virus NS1 reveals a role in early RNA replication.
Vesicular Stomatitis Virus and DNA Vaccines Expressing Zika Virus Nonstructural Protein 1 Induce Substantial but Not Sterilizing Protection against Zika Virus Infection.
Yellow Fever virus NS3 plays an essential role in virus assembly independent of its known enzymatic functions.
Yersinia Infections
Identification of beta-subunit of bacterial RNA-polymerase--a non-species-specific bacterial protein--as target of antibodies in primary biliary cirrhosis.
Zika Virus Infection
Cranial US in Infants Exposed to Zika Virus: The NATZIG Cohort.
Delayed and highly specific antibody response to nonstructural protein 1 (NS1) revealed during natural human ZIKV infection by NS1-based capture ELISA.
Diagnosis of Zika virus infection on a nanotechnology platform.
Doubled dosage of sofosbuvir is expected for inhibiting Zika virus infection.
Novel guanosine derivatives against Zika virus polymerase in silico.
Nuclear import inhibitor N-(4-hydroxyphenyl) retinamide targets Zika virus (ZIKV) nonstructural protein 5 to inhibit ZIKV infection.
Ribavirin inhibits Zika virus (ZIKV) replication in vitro and suppresses viremia in ZIKV-infected STAT1-deficient mice.
Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference.
The NLRP3 inflammasome activation mediates Zika virus associated inflammation.
The Potential Role of the ZIKV NS5 Nuclear Spherical-Shell Structures in Cell Type-Specific Host Immune Modulation during ZIKV Infection.
The Screening of phytochemicals against NS5 Polymerase to treat Zika Virus infection: Integrated computational based approach.
Use of Urea Wash ELISA to Distinguish Zika and Dengue Virus Infections.
Vesicular Stomatitis Virus and DNA Vaccines Expressing Zika Virus Nonstructural Protein 1 Induce Substantial but Not Sterilizing Protection against Zika Virus Infection.
Zika Virus NS5 Forms Supramolecular Nuclear Bodies That Sequester Importin-? and Modulate the Host Immune and Pro-Inflammatory Response in Neuronal Cells.