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Disease on EC 2.7.7.2 - FAD synthase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
acyl-coa dehydrogenase deficiency
A Novel Truncating FLAD1 Variant, Causing Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) in an 8-Year-Old Boy.
Bacterial Production, Characterization and Protein Modeling of a Novel Monofuctional Isoform of FAD Synthase in Humans: An Emergency Protein?
Infant with early onset bilateral facial and bulbar weakness: Successful treatment of riboflavin in multiple acyl-CoA dehydrogenase deficiency caused by biallelic nonsense FLAD1 variants.
Adenoma
Bioinformatics Analysis Reveals Most Prominent Gene Candidates to Distinguish Colorectal Adenoma from Adenocarcinoma.
Aggressive Periodontitis
[Association between FADS1 rs174537 polymorphism and serum proteins in patients with aggressive periodontitis].
Alzheimer Disease
Genetic variants in FADS1 and ELOVL2 increase level of arachidonic acid and the risk of Alzheimer's disease in the Tunisian population.
Aortic Aneurysm, Abdominal
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study.
Aortic Valve Stenosis
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study.
Asthma
FADS gene cluster modulates the effect of breastfeeding on asthma. Results from the GINIplus and LISAplus studies.
Breast Neoplasms
Significant Diagnostic and Prognostic Value of FLAD1 and Related MicroRNAs in Breast Cancer after a Pan-Cancer Analysis.
Suppression of Nuclear Factor-?B by Glucocorticoid Receptor Blocks Estrogen-Induced Apoptosis in Estrogen-Deprived Breast Cancer Cells.
Carcinogenesis
Decreased Expression of FADS1 Predicts a Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma.
Carcinoma
Bioinformatics Analysis Reveals Most Prominent Gene Candidates to Distinguish Colorectal Adenoma from Adenocarcinoma.
Decreased Expression of FADS1 Predicts a Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma.
FADS1 promotes the progression of laryngeal squamous cell carcinoma through activating AKT/mTOR signaling.
Cardiovascular Diseases
Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque.
Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease.
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study.
[Desaturases of fatty acids (FADS) and their physiological and clinical implication].
Cataract
FLAD1, encoding FAD synthase, is mutated in a patient with myopathy, scoliosis and cataracts.
Coronary Artery Disease
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study.
Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease.
Coronary Disease
Genetic variants in the metabolism of omega-6 and omega-3 fatty acids: their role in the determination of nutritional requirements and chronic disease risk.
Deficiency Diseases
Patient with multiple acyl-CoA dehydrogenation deficiency disease and FLAD1 mutations benefits from riboflavin therapy.
Diabetes Mellitus, Type 2
Association of Polymorphism in Fatty Acid Desaturase Gene with the Risk of Type 2 Diabetes in Iranian Population.
Common Type 2 Diabetes Genetic Risk Variants Improve the Prediction of Gestational Diabetes.
Effects of 34 Risk Loci for Type 2 Diabetes or Hyperglycemia on Lipoprotein Subclasses and Their Composition in 6,580 Nondiabetic Finnish Men.
FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes.
Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations.
Diabetes, Gestational
GCK, GCKR, FADS1, DGKB/TMEM195 and CDKAL1 Gene Polymorphisms in Women with Gestational Diabetes.
Dyslipidemias
Heterozygous Nme7 Mutation Affects Glucose Tolerance in Male Rats.
Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans.
Eczema
Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life.
Esophageal Squamous Cell Carcinoma
Decreased Expression of FADS1 Predicts a Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma.
fad synthase deficiency
Disorders of Riboflavin Metabolism.
FLAD1-associated multiple acyl-CoA dehydrogenase deficiency identified by newborn screening.
Post-mortem detection of FLAD1 mutations in 2 Turkish siblings with hypotonia in early infancy.
Fatty Liver
Fads1 and 2 are promoted to meet instant need for long-chain polyunsaturated fatty acids in goose fatty liver.
Heterozygous Nme7 Mutation Affects Glucose Tolerance in Male Rats.
Hyperglycemia
Effects of 34 Risk Loci for Type 2 Diabetes or Hyperglycemia on Lipoprotein Subclasses and Their Composition in 6,580 Nondiabetic Finnish Men.
Hypersensitivity
[Desaturases of fatty acids (FADS) and their physiological and clinical implication].
Hypertension
A case-control study between gene polymorphisms of polyunsaturated fatty acid metabolic rate-limiting enzymes and acute coronary syndrome in Chinese Han population.
[Desaturases of fatty acids (FADS) and their physiological and clinical implication].
Hypospadias
Post-mortem detection of FLAD1 mutations in 2 Turkish siblings with hypotonia in early infancy.
Infections
Flavin metabolism during respiratory infection in mice.
Insulin Resistance
Abnormal Expression of Genes Involved in Inflammation, Lipid Metabolism, and Wnt Signaling in the Adipose Tissue of Polycystic Ovary Syndrome.
Fatty Acid desaturase gene polymorphisms and metabolic measures in schizophrenia and bipolar patients taking antipsychotics.
Gene Expression Signature in Adipose Tissue of Acromegaly Patients.
Genetic loci associated with lipid concentrations and cardiovascular risk factors in a Korean population.
Ischemic Stroke
Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease.
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study.
Liver Diseases
Fatty Acid Desaturase 1 Influences Hepatic Lipid Homeostasis by Modulating the PPAR?-FGF21 Axis.
In a pilot study, reduced fatty acid desaturase 1 function was associated with nonalcoholic fatty liver disease and response to treatment in children.
Lung Neoplasms
Reduced Expression of FADS1 Predicts Worse Prognosis in Non-Small-Cell Lung Cancer.
Malnutrition
Disorders of Riboflavin Metabolism.
Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme.
Metabolic Diseases
FLAD1-associated multiple acyl-CoA dehydrogenase deficiency identified by newborn screening.
Metabolic Syndrome
Association Between Genetic Variants in FADS1-FADS2 and ELOVL2 and Obesity, Lipid Traits, and Fatty Acids in Tunisian Population.
Carrying minor allele of FADS1 and haplotype of FADS1 and FADS2 increased the risk of metabolic syndrome and moderate but not low fat diets lowered the risk in two Korean cohorts.
FADS1 modulates metabolic syndrome in schizophrenia patients receiving olanzapine monotherapy.
Interaction of Dietary Linoleic Acid and ?-Linolenic Acids with rs174547 in FADS1 Gene on Metabolic Syndrome Components among Vegetarians.
[Desaturases of fatty acids (FADS) and their physiological and clinical implication].
Metabolism, Inborn Errors
Riboflavin-Responsive and -Non-responsive Mutations in FAD Synthase Cause Multiple Acyl-CoA Dehydrogenase and Combined Respiratory-Chain Deficiency.
Mitochondrial Diseases
Mutation of Aspartate 238 in FAD Synthase Isoform 6 Increases the Specific Activity by Weakening the FAD Binding.
Post-mortem detection of FLAD1 mutations in 2 Turkish siblings with hypotonia in early infancy.
Use of whole-exome sequencing to determine the genetic basis of multiple mitochondrial respiratory chain complex deficiencies.
Mouth Neoplasms
FADS1 rs174549 Polymorphism May Predict a Favorable Response to Chemoradiotherapy in Oral Cancer Patients.
Novel polymorphism in FADS1 gene and fish consumption on risk of oral cancer: A case-control study in southeast China.
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
A Novel Truncating FLAD1 Variant, Causing Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) in an 8-Year-Old Boy.
Bacterial Production, Characterization and Protein Modeling of a Novel Monofuctional Isoform of FAD Synthase in Humans: An Emergency Protein?
Infant with early onset bilateral facial and bulbar weakness: Successful treatment of riboflavin in multiple acyl-CoA dehydrogenase deficiency caused by biallelic nonsense FLAD1 variants.
Muscle Hypotonia
Post-mortem detection of FLAD1 mutations in 2 Turkish siblings with hypotonia in early infancy.
Muscular Diseases
FLAD1, encoding FAD synthase, is mutated in a patient with myopathy, scoliosis and cataracts.
Neoplasms
Decreased Expression of FADS1 Predicts a Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma.
Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme.
FADS1 is a Prognostic Biomarker in Bladder Cancer: A Study Based on TCGA Data.
Fatty acid desaturase 2 (FADS2) but not FADS1 desaturates branched chain and odd chain saturated fatty acids.
FLAD1 is up-regulated in Gastric Cancer and is a potential prediction of prognosis.
Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study.
Identification of FADS1 Through Common Gene Expression Profiles for Predicting Survival in Patients with Bladder Cancer.
Prediction of Postoperative Recurrence-Free Survival in Non-small Cell Lung Cancer by Using an Internationally Validated Gene Expression Model.
Reduced Expression of FADS1 Predicts Worse Prognosis in Non-Small-Cell Lung Cancer.
Significant Diagnostic and Prognostic Value of FLAD1 and Related MicroRNAs in Breast Cancer after a Pan-Cancer Analysis.
Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling, and Sensitive Detection of a Cancer Biomarker.
[Desaturases of fatty acids (FADS) and their physiological and clinical implication].
Non-alcoholic Fatty Liver Disease
Fatty Acid Desaturase 1 Influences Hepatic Lipid Homeostasis by Modulating the PPAR?-FGF21 Axis.
In a pilot study, reduced fatty acid desaturase 1 function was associated with nonalcoholic fatty liver disease and response to treatment in children.
Obesity
Association between rs174537 FADS1 polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity.
Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population.
Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque.
Gene-diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men.
Liver DNA methylation of FADS2 associates with FADS2 genotypex.
Overweight
Associations among FADS1 rs174547, eicosapentaenoic acid/arachidonic acid ratio, and arterial stiffness in overweight subjects.
Scoliosis
FLAD1, encoding FAD synthase, is mutated in a patient with myopathy, scoliosis and cataracts.
Squamous Cell Carcinoma of Head and Neck
FADS1 promotes the progression of laryngeal squamous cell carcinoma through activating AKT/mTOR signaling.
Stomach Neoplasms
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
Dietary n-3 and n-6 polyunsaturated fatty acids, the FADS gene, and the risk of gastric cancer in a Korean population.
FLAD1 is up-regulated in Gastric Cancer and is a potential prediction of prognosis.
Stroke
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study.
Urinary Bladder Neoplasms
FADS1 is a Prognostic Biomarker in Bladder Cancer: A Study Based on TCGA Data.
Identification of FADS1 Through Common Gene Expression Profiles for Predicting Survival in Patients with Bladder Cancer.
Vascular System Injuries
Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque.
Venous Thromboembolism
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study.
Vitiligo
Suppression of FADS1 induces ROS generation, cell cycle arrest, and apoptosis in melanocytes: implications for vitiligo.