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ATP + thiamine
AMP + thiamine diphosphate
CTP + thiamine
CMP + thiamine diphosphate
GTP + thiamine
GMP + thiamine diphosphate
oxythiamine + ATP
oxythiamine diphosphate + AMP
-
-
-
-
?
pyrithiamine + ATP
pyrithiamine diphosphate + AMP
thiamin + ATP
thiamindiphosphate + AMP
-
-
-
?
thiamine + ATP
thiamine diphosphate + AMP
UTP + thiamine
UMP + thiamine diphosphate
additional information
?
-
ATP + thiamine

AMP + thiamine diphosphate
thiamine pyrophosphokinase is required for thiamine cofactor activation in Arabidopsis
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
no TMP kinase activity is shown by either isozymes TPK1 or TPK2
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
the tpk-1 gene functions cell nonautonomously, as the expression of wild-type tpk-1 in one tissue can residue the function of other tissues that express only mutant tpk-1. Thiamine diphosphate can be transported across the cell membrane
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
-
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
-
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
-
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
-
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
Q59N99
-
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
Q59N99
importance of TPP/thiamine in the alpha-oxidation pathway. Most TPP is tightly bound to peroxisomal proteins, most likely to 2-hydroxyacyl-CoA lyase 1, HACL1, or membranes
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
-
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
-
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
-
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
-
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
importance of TPP/thiamine in the alpha-oxidation pathway. Most TPP is tightly bound to peroxisomal proteins, most likely to 2-hydroxyacyl-CoA lyase 1, HACL1, or membranes
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
-
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
the enzyme is important for the formation of the coenzyme thiamine diphosphate
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
enzyme is involved in biosynthesis of thiamine diphosphate
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
the enzyme is a regulator of thiamine metabolism, phosphate metabolism, mating, and growth
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
-
-
-
?
CTP + thiamine

CMP + thiamine diphosphate
-
-
-
-
?
CTP + thiamine
CMP + thiamine diphosphate
31.4% of the activity with ATP
-
-
?
GTP + thiamine

GMP + thiamine diphosphate
-
-
-
-
?
GTP + thiamine
GMP + thiamine diphosphate
-
GTP is the preferred nucleotide
-
-
-
GTP + thiamine
GMP + thiamine diphosphate
18.3% of the activity with ATP
-
-
?
pyrithiamine + ATP

pyrithiamine diphosphate + AMP
-
inhibits the substrate thiamine
-
-
?
pyrithiamine + ATP
pyrithiamine diphosphate + AMP
-
its specific activity is 30% lower in comparison to its natural substrate thiamine
-
-
?
thiamine + ATP

thiamine diphosphate + AMP
-
-
-
-
?
thiamine + ATP
thiamine diphosphate + AMP
-
-
-
-
-
thiamine + ATP
thiamine diphosphate + AMP
-
TPP plays a critical role in the carbohydrate and energy metabolism. It functions as a prosthetic group for the mitochondrial enzyme complexes like pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and branched chain alpha-keto acid dehydrogenase. In addition, TPP is involved in the cytosolic pentose pathway functioning as coenzyme for transketolase.
-
-
?
thiamine + ATP
thiamine diphosphate + AMP
-
-
-
-
-
thiamine + ATP
thiamine diphosphate + AMP
-
-
-
-
-
UTP + thiamine

UMP + thiamine diphosphate
-
-
-
-
?
UTP + thiamine
UMP + thiamine diphosphate
207% of the activity with ATP
-
-
?
additional information

?
-
-
thiamine binding site structure, overview
-
-
-
additional information
?
-
-
three common intronic variants in the maternal and fetal thiamine pyrophosphokinase gene (TPK1) are associated with birth weight, overview
-
-
-
additional information
?
-
-
the YcfN protein acts as a nonspecific adenosylcobinamide kinase enzyme, which is not associated with adenosylcobalamine biosynthesis, but it allows a CobU-deficient strain of serovar Typhimurium to synthesize enough adenosylcobalamine from cobinamide so that the cell can grow. YcfN is required for the phosphorylation of thiamine in the thiamine salvaging pathway of Escherichia coli
-
-
-
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ATP + thiamine
AMP + thiamine diphosphate
thiamin + ATP
thiamindiphosphate + AMP
F4IV16
-
-
-
?
thiamine + ATP
thiamine diphosphate + AMP
additional information
?
-
ATP + thiamine

AMP + thiamine diphosphate
F4IV16
thiamine pyrophosphokinase is required for thiamine cofactor activation in Arabidopsis
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
P30636
the tpk-1 gene functions cell nonautonomously, as the expression of wild-type tpk-1 in one tissue can residue the function of other tissues that express only mutant tpk-1. Thiamine diphosphate can be transported across the cell membrane
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
Q9H3S4
-
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
Q59N99
importance of TPP/thiamine in the alpha-oxidation pathway. Most TPP is tightly bound to peroxisomal proteins, most likely to 2-hydroxyacyl-CoA lyase 1, HACL1, or membranes
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
importance of TPP/thiamine in the alpha-oxidation pathway. Most TPP is tightly bound to peroxisomal proteins, most likely to 2-hydroxyacyl-CoA lyase 1, HACL1, or membranes
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
-
the enzyme is important for the formation of the coenzyme thiamine diphosphate
-
-
?
ATP + thiamine
AMP + thiamine diphosphate
P41888
the enzyme is a regulator of thiamine metabolism, phosphate metabolism, mating, and growth
-
-
?
thiamine + ATP

thiamine diphosphate + AMP
-
-
-
-
?
thiamine + ATP
thiamine diphosphate + AMP
-
-
-
-
-
thiamine + ATP
thiamine diphosphate + AMP
-
TPP plays a critical role in the carbohydrate and energy metabolism. It functions as a prosthetic group for the mitochondrial enzyme complexes like pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and branched chain alpha-keto acid dehydrogenase. In addition, TPP is involved in the cytosolic pentose pathway functioning as coenzyme for transketolase.
-
-
?
thiamine + ATP
thiamine diphosphate + AMP
-
-
-
-
-
thiamine + ATP
thiamine diphosphate + AMP
-
-
-
-
-
additional information

?
-
-
three common intronic variants in the maternal and fetal thiamine pyrophosphokinase gene (TPK1) are associated with birth weight, overview
-
-
-
additional information
?
-
-
the YcfN protein acts as a nonspecific adenosylcobinamide kinase enzyme, which is not associated with adenosylcobalamine biosynthesis, but it allows a CobU-deficient strain of serovar Typhimurium to synthesize enough adenosylcobalamine from cobinamide so that the cell can grow. YcfN is required for the phosphorylation of thiamine in the thiamine salvaging pathway of Escherichia coli
-
-
-
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0.045
thiamin
-
pH 7.5, 37°C, mutant enzyme Q96E
0.0002
ATP

-
pH 7.5, 37°C, mutant enzyme D100N
0.0003
ATP
-
pH 7.5, 37°C, mutant enzyme D73N
0.0005
ATP
-
pH 7.5, 37°C, mutant enzyme D71N
0.026
ATP
-
pH 7.5, 37°C, mutant enzyme T99A
0.028
ATP
-
pH 7.5, 37°C, mutant enzyme R131G
0.034
ATP
-
pH 7.5, 37°C, mutant enzyme D133N
0.045
ATP
-
pH 7.5, 37°C, mutant enzyme Q96E
0.069
ATP
-
pH 7.5, 37°C, wild-type enzyme
0.094
ATP
-
pH 7.5, 37°C, mutant enzyme S74A
0.0002
thiamine

-
pH 7.5, 37°C, mutant enzyme D100N
0.0003
thiamine
-
pH 7.5, 37°C, mutant enzyme D73N
0.0005
thiamine
-
pH 7.5, 37°C, mutant enzyme D71N
0.026
thiamine
-
pH 7.5, 37°C, mutant enzyme T99A
0.028
thiamine
-
pH 7.5, 37°C, mutant enzyme R131G
0.034
thiamine
-
pH 7.5, 37°C, mutant enzyme D133N
0.069
thiamine
-
pH 7.5, 37°C, wild-type enzyme
0.094
thiamine
-
pH 7.5, 37°C, mutant enzyme S74A
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Anemia
Chronic non-spherocytic haemolytic anaemia due to congenital pyrimidine 5' nucleotidase deficiency: 25 years later.
Anemia
Nonspherocytic haemolytic anaemia with increased red cell adenine nucleotides, glutathione and basophilic stippling and ribosephosphate pyrophosphokinase (RPK) deficiency: studies on two new kindreds.
Anemia
Studies on human erythrocyte nucleotide metabolism. II. Nonspherocytic hemolytic anemia, high red cell ATP, and ribosephosphate pyrophosphokinase (RPK, E.C.2.7.6.1) deficiency.
Anemia
Thiamine responsive anemia: report of a new case associated with a thiamine pyrophosphokinase deficiency.
Anemia
[Phosphoribosyl pyrophosphate and its metabolic enzymes in the erythrocytes in certain forms of anemia]
Anemia, Hemolytic
Additional data from two kindreds with genetically induced deficiencies of erythrocyte pyrimidine nucleotidase.
Anemia, Hemolytic
Studies on human erythrocyte nucleotide metabolism. II. Nonspherocytic hemolytic anemia, high red cell ATP, and ribosephosphate pyrophosphokinase (RPK, E.C.2.7.6.1) deficiency.
Anemia, Megaloblastic
Thiamine transport by erythrocytes and ghosts in thiamine-responsive megaloblastic anaemia.
Anemia, Megaloblastic
Thiamine-responsive megaloblastic anemia with diabetes mellitus and sensorineural deafness.
Avitaminosis
[Enzyme activity of thiamine diphosphate biosynthesis and degradation in the mouse liver in the dynamics of B1 avitaminosis development]
Carcinoma
Thiamine metabolism in the liver of mice with Ehrlich ascites carcinoma.
Carcinoma, Hepatocellular
Increased 5-phospho-alpha-D-ribose-1-diphosphate synthetase (ribosephosphate pyrophosphokinase, EC 2.7.6.1) activity in rat hepatomas.
Cardiotoxicity
Examination of the effects of thiamine and thiamine pyrophosphate on Doxorubicin-induced experimental cardiotoxicity.
Deafness
Thiamine-responsive megaloblastic anemia with diabetes mellitus and sensorineural deafness.
Diabetes Mellitus
Thiamine-responsive megaloblastic anemia with diabetes mellitus and sensorineural deafness.
Leigh Disease
Thiamine metabolism is critical for regulating correlated growth of dendrite arbors and neuronal somata.
Leigh Disease
Thiamine pyrophosphokinase deficiency causes a Leigh Disease like phenotype in a sibling pair: identification through whole exome sequencing and management strategies.
Malaria
Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine.
Malaria
The human malaria parasite Plasmodium falciparum expresses an atypical N-terminally extended pyrophosphokinase with specificity for thiamine.
Microcephaly
Thiamine metabolism is critical for regulating correlated growth of dendrite arbors and neuronal somata.
Neoplasms
Thiamine metabolism in the liver of mice with Ehrlich ascites carcinoma.
Neoplasms
[Extracting and study of biochemical properties of thiamine pyrophosphokinase from non-malignant and tumor tissue of myometrium].
Nervous System Diseases
Expanding the clinical and molecular spectrum of thiamine pyrophosphokinase deficiency: a treatable neurological disorder caused by TPK1 mutations.
Nervous System Diseases
Thiamine metabolism is critical for regulating correlated growth of dendrite arbors and neuronal somata.
Pneumonia, Pneumocystis
Cloning of the Pneumocystis jirovecii trifunctional FAS gene and complementation of its DHPS activity in Escherichia coli.
Thiamine Deficiency
Brain thiamine, its phosphate esters, and its metabolizing enzymes in Alzheimer's disease.
thiamine diphosphokinase deficiency
Expanding the clinical and molecular spectrum of thiamine pyrophosphokinase deficiency: a treatable neurological disorder caused by TPK1 mutations.
thiamine diphosphokinase deficiency
Thiamine pyrophosphokinase deficiency causes a Leigh Disease like phenotype in a sibling pair: identification through whole exome sequencing and management strategies.
thiamine diphosphokinase deficiency
Thiamine pyrophosphokinase deficiency in encephalopathic children with defects in the pyruvate oxidation pathway.
thiamine diphosphokinase deficiency
Thiamine responsive anemia: report of a new case associated with a thiamine pyrophosphokinase deficiency.
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Steyn-Parve, E.P.
Partial purification and properties of thiaminokinase from yeast
Biochim. Biophys. Acta
8
310-324
1952
Saccharomyces cerevisiae
brenda
Onozuka, M.; Nosaka, K.
Steady-state kinetics and mutational studies of recombinant human thiamin pyrophosphokinase
J. Nutr. Sci. Vitaminol.
49
156-162
2003
Homo sapiens, Homo sapiens (Q9H3S4)
brenda
Howle, P.K.W.; Fites, R.C.
GTP-specific pyrophosphorylation of thiamin in dark-grown soybean (Glycine max) seddling axes
Physiol. Plant.
81
24-30
1991
Glycine max
-
brenda
Mitsuda, H.; Takii, Y.; Iwami, K.; Yasumoto, K.
Mechanism and regulation of thiamine pyrophosphokinase from parsely leaf
J. Nutr. Sci. Vitaminol.
21
189-198
1975
Petroselinum crispum
brenda
Mitsuda, H.; Takii, Y.; Kimikazu, I.; Yasumoto, K.
Purification and properties of thiamine pyrophosphokinase from parsely leaf
J. Nutr. Sci. Vitaminol.
21
103-115
1975
Petroselinum crispum
brenda
Wakabayashi, Y.; Iwashima, A.; Nose, Y.
Affinity chromatography of thiamine pyrophosphokinase from rat brain on thiamine monophosphate-agarose
Methods Enzymol.
62
105-107
1979
Rattus norvegicus
brenda
Mitsuda, H.; Takii, Y.; Iwami, K.; Yasumoto, K.; Nakajima, K.
Enzymatic formation of thiamine pyrophosphate in plants
Methods Enzymol.
62
107-111
1979
Petroselinum crispum
brenda
Sanemori, H.; Kawasaki, T.
Purification and properties of thiamine pyrophosphokinase in Paracoccus denitrificans
J. Biochem.
88
223-230
1980
Paracoccus denitrificans 12442, Paracoccus denitrificans
brenda
Wakabayashi, Y.; Iwashima, A.; Nose, Y.
Affinity chromatohraphy of thiamin pyrophosphokinase of rat brain
Biochim. Biophys. Acta
429
1087-1089
1976
Rattus norvegicus
-
brenda
Peterson, J.W.; Gubler, C.J.; Kuby, S.A.
Partial purification and properties of thiamine pyrophosphokinase from pig brain
Biochim. Biophys. Acta
397
377-394
1975
Sus scrofa
brenda
Okazaki, K.
Evidence for existence and a tentative identification of coenzyme in yeast thiamine pyrophosphokinase
Biochem. Biophys. Res. Commun.
64
20-27
1975
Saccharomyces cerevisiae
brenda
Molin, W.T.; Fites, R.C.
Isolation and characterization of thiamin pyrophosphotransferase from Glycine max seedlings
Plant Physiol.
66
308-312
1980
Glycine max
brenda
Baker, L.J.; Dorocke, J.A.; Harris, R.A.; Timm, D.E.
The crystal structure of yeast thiamin pyrophosphokinase
Structure
9
539-546
2001
Saccharomyces cerevisiae
brenda
Zhao, R.; Gao, F.; Goldman, I.D.
Molecular cloning of human thiamin pyrophosphokinase
Biochim. Biophys. Acta
1517
320-322
2001
Homo sapiens, Homo sapiens (Q9H3S4)
brenda
Timm, D.E.; Liu, J.; Baker, L.J.; Harris, R.A.
Crystal structure of thiamin pyrophosphokinase
J. Mol. Biol.
310
195-204
2001
Mus musculus
brenda
Frankhauser, H.; Zurlinden, A.; Schweingruber, A.M.; Edenharter, E.; Schweingruber, M.E.
Schizosaccharomyces pombe thiamin pyrophosphokinase is encoded by gene tnr3 and is a regulator of thiamin metabolism, phosphate metabolism, mating, and growth
J. Biol. Chem.
270
28457-28462
1995
Schizosaccharomyces pombe (P41888), Schizosaccharomyces pombe
brenda
Melnick, J.S.; Sprinz, K.I.; Reddick, J.J.; Kinsland, C.; Begley, T.P.
An efficient enzymatic synthesis of thiamin pyrophosphate
Bioorg. Med. Chem. Lett.
13
4139-4141
2003
Saccharomyces cerevisiae
brenda
de Jong, L.; Meng, Y.; Dent, J.; Hekimi, S.
Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans
Genetics
168
845-854
2004
Caenorhabditis elegans, Caenorhabditis elegans (P30636)
brenda
Eschbach, M.L.; Mueller, I.B.; Gilberger, T.W.; Walter, R.D.; Wrenger, C.
The human malaria parasite Plasmodium falciparum expresses an atypical N-terminally extended pyrophosphokinase with specificity for thiamine
Biol. Chem.
387
1583-1591
2006
Plasmodium falciparum, Saccharomyces cerevisiae, Schizosaccharomyces pombe
brenda
Fraccascia, P.; Sniekers, M.; Casteels, M.; Van Veldhoven, P.P.
Presence of thiamine pyrophosphate in mammalian peroxisomes
BMC Biochem.
8
10
2007
Mus musculus (Q59N99), Rattus norvegicus
brenda
Otte, M.M.; Woodson, J.D.; Escalante-Semerena, J.C.
The thiamine kinase (YcfN) enzyme plays a minor but significant role in cobinamide salvaging in Salmonella enterica
J. Bacteriol.
189
7310-7315
2007
Salmonella enterica
brenda
Liu, J.; Timm, D.E.; Hurley, T.D.
Pyrithiamine as a substrate for thiamine pyrophosphokinase
J. Biol. Chem.
281
6601-6607
2006
Mus musculus
brenda
Ajjawi, I.; Rodriguez Milla, M.A.; Cushman, J.; Shintani, D.K.
Thiamin pyrophosphokinase is required for thiamin cofactor activation in Arabidopsis
Plant Mol. Biol.
65
151-162
2007
Arabidopsis thaliana, Arabidopsis thaliana (F4IV16)
brenda
Fradin, D.; Bougneres, P.
Three common intronic variants in the maternal and fetal thiamine pyrophosphokinase gene (TPK1) are associated with birth weight
Ann. Hum. Genet.
71
578-585
2007
Homo sapiens
brenda
Santini, S.; Monchois, V.; Mouz, N.; Sigoillot, C.; Rousselle, T.; Claverie, J.; Abergel, C.
Structural characterization of CA1462, the Candida albicans thiamine pyrophosphokinase
BMC Struct. Biol.
8
0000
2008
Candida albicans
-
brenda
Yuge, S.; Richter, C.A.; Wright-Osment, M.K.; Nicks, D.; Saloka, S.K.; Tillitt, D.E.; Li, W.
Identification of the thiamin pyrophosphokinase gene in rainbow trout: characteristic structure and expression of seven splice variants in tissues and cell lines and during embryo development
Comp. Biochem. Physiol. B
163
193-202
2012
Oncorhynchus mykiss (I3PU26)
brenda
Liu, J.Y.; Hurley, T.D.
A new crystal form of mouse thiamin pyrophosphokinase
Int. J. Biochem. Mol. Biol.
2
111-118
2011
Mus musculus
brenda
Krautwald, M.; Leech, D.; Horne, S.; Steele, M.L.; Forbes, J.; Rahmadi, A.; Griffith, R.; Muench, G.
The advanced glycation end product-lowering agent ALT-711 is a low-affinity inhibitor of thiamine diphosphokinase
Rejuvenation Res.
14
383-391
2011
Homo sapiens
brenda
Banka, S.; de Goede, C.; Yue, W.W.; Morris, A.A.; von Bremen, B.; Chandler, K.E.; Feichtinger, R.G.; Hart, C.; Khan, N.; Lunzer, V.; Matakovi?, L.; Marquardt, T.; Makowski, C.; Prokisch, H.; Debus, O.; Nosaka, K.; Sonwalkar, H.; Zimmermann, F.A.; Sperl, W.; Mayr, J.A.
Expanding the clinical and molecular spectrum of thiamine pyrophosphokinase deficiency: a treatable neurological disorder caused by TPK1 mutations
Mol. Genet. Metab.
113
301-306
2014
Homo sapiens, Homo sapiens (Q9H3S4)
brenda