Information on EC 2.7.4.B1 - yeast UMP kinase

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The expected taxonomic range for this enzyme is: Saccharomyces cerevisiae

EC NUMBER
COMMENTARY hide
2.7.4.B1
preliminary BRENDA-supplid EC number
RECOMMENDED NAME
GeneOntology No.
yeast UMP kinase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a nucleoside monophosphate = ADP + a nucleotide diphosphate
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
ATP:NMP phosphotransferase
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 5-iodo-dUMP
ADP + 5-iodo-dUDP
show the reaction diagram
reaction occurs to a lesser extent
-
-
?
ATP + dGMP
ADP + dGDP
show the reaction diagram
reaction occurs to a lesser extent
-
-
?
ATP + dTMP
ADP + dTDP
show the reaction diagram
reaction occurs to a lesser extent
-
-
?
ATP + dUMP
ADP + dUDP
show the reaction diagram
-
-
-
?
ATP + GMP
ADP + GDP
show the reaction diagram
reaction occurs to a lesser extent
-
-
?
ATP + IMP
ADP + IDP
show the reaction diagram
reaction occurs to a lesser extent
-
-
?
ATP + UMP
ADP + UDP
show the reaction diagram
ATP + XMP
ADP + XDP
show the reaction diagram
reaction occurs to a lesser extent
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-
?
CTP + UMP
CDP + UDP
show the reaction diagram
reaction rate is 10-14% of that with ATP or dATP
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-
?
dATP + UMP
dADP + UDP
show the reaction diagram
-
-
-
?
dCTP + UMP
dCDP + UDP
show the reaction diagram
reaction rate is 30-50% of that with ATP or dATP
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-
?
dGTP + UMP
dGDP + UDP
show the reaction diagram
reaction rate is 30-50% of that with ATP or dATP
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-
?
dTTP + UMP
dTDP + UDP
show the reaction diagram
reaction rate is 30-50% of that with ATP or dATP
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-
?
GTP + UMP
GDP + UDP
show the reaction diagram
reaction rate is 30-50% of that with ATP or dATP
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-
?
UTP + UMP
UDP + UDP
show the reaction diagram
reaction rate is 10-14% of that with ATP or dATP
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-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + UMP
ADP + UDP
show the reaction diagram
P15700
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-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
57% activity at 7.5 mM
Cd2+
no activity at 7.5 mM
Co2+
99% activity at 7.5 mM
Cu2+
11% activity at 7.5 mM
Fe2+
24% activity at 7.5 mM
Mg2+
100% activity at 7.5 mM
Mn2+
100% activity at 7.5 mM
Ni2+
84% activity at 7.5 mM
Zn2+
14% activity at 7.5 mM
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5,5'-dithio-bis(2-nitrobenzoic acid)
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25000
monomer, SDS-PAGE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50
enzyme activity decreases to 55%. In the presence of 1 mM UTP enzyme activity decreases to 73%. In the presence of 10% glycerol enzyme activity decreases to 77%. In the presence of 10% polyethylene glycol enzyme activity decreases to 95%. In the presence of 10 mM DTT enzyme activity decreases to 80%
60
enzyme activity decreases to 3%. In the presence of 1 mM UTP enzyme activity decreases to 10%. In the presence of 10% glycerol enzyme activity decreases to 14%. In the presence of 10% polyethylene glycol enzyme activity decreases to 34%. In the presence of 10 mM DTT enzyme activity decreases to 68%
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE