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Disease on EC 2.7.4.21 - inositol-hexakisphosphate 5-kinase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Alzheimer Disease
Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease.
Amyotrophic Lateral Sclerosis
Inositol Hexakisphosphate Kinase 2 is a Presymptomatic Biomarker for Amyotrophic Lateral Sclerosis.
Inositol hexakisphosphate kinase 2 promotes cell death of anterior horn cells in the spinal cord of patients with amyotrophic lateral sclerosis.
Autoimmune Diseases
Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles.
Breast Neoplasms
IP6K2 predicts favorable clinical outcome of primary breast cancer.
miR-125a-5p impairs the metastatic potential in breast cancer via IP6K1 targeting.
Carcinogenesis
Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice.
The Key Role of IP6K: A Novel Target for Anticancer Treatments?
Carcinoma
Apo2L/TRAIL induction and nuclear translocation of inositol hexakisphosphate kinase 2 during IFN-beta-induced apoptosis in ovarian carcinoma.
Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice.
Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation.
Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma.
Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells.
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics.
Colorectal Neoplasms
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2.
Confusion
Multiple aspects of male germ cell development and interactions with Sertoli cells require inositol hexakisphosphate kinase-1.
Fatty Liver
Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases.
Hearing Loss
Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse.
Hyperinsulinism
Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases.
Hypersensitivity
A G-protein ? subunit, AGB1, negatively regulates the ABA response and drought tolerance by down-regulating AtMPK6-related pathway in Arabidopsis.
Infections
Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response.
Infertility
IP6K1 is essential for chromatoid body formation and temporal regulation of Tnp2 and Prm2 expression in mouse spermatids.
Influenza, Human
Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response.
Insulin Resistance
Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis.
Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes.
Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain.
High intensity exercise decreases IP6K1 muscle content & improves insulin sensitivity (SI2*) in glucose intolerant individuals.
Ingestion of lean meat elevates muscle inositol hexakisphosphate kinase 1 protein content independent of a distinct post-prandial circulating proteome in young adults with obesity.
Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis.
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain.
IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution.
Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases.
The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle.
TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway.
Keratoconus
PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus.
Neoplasm Metastasis
Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1.
miR-125a-5p impairs the metastatic potential in breast cancer via IP6K1 targeting.
Neoplasms
Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice.
Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation.
HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.
Identification of novel Sp1 targets involved in proliferation and cancer by functional genomics.
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics.
Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1.
IP6K2 is a client for HSP90 and a target for cancer therapeutics development.
IP6K2 predicts favorable clinical outcome of primary breast cancer.
miR-125a-5p impairs the metastatic potential in breast cancer via IP6K1 targeting.
Serum miR-1181 and miR-4314 associated with ovarian cancer: MiRNA microarray data analysis for a pilot study.
The Key Role of IP6K: A Novel Target for Anticancer Treatments?
Neurodegenerative Diseases
Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease.
Obesity
Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis.
Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain.
Ingestion of lean meat elevates muscle inositol hexakisphosphate kinase 1 protein content independent of a distinct post-prandial circulating proteome in young adults with obesity.
Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis.
Inositol pyrophosphates as mammalian cell signals.
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain.
IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution.
Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases.
TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway.
Pancreatitis
Platelet IP6K1 regulates neutrophil extracellular trap-microparticle complex formation in acute pancreatitis.
Pneumonia, Bacterial
Inhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia.
Sarcopenia
The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle.