Disease on EC 2.7.4.21 - inositol-hexakisphosphate 5-kinase
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Alzheimer Disease
Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease.
Amyotrophic Lateral Sclerosis
Inositol Hexakisphosphate Kinase 2 is a Presymptomatic Biomarker for Amyotrophic Lateral Sclerosis.
Amyotrophic Lateral Sclerosis
Inositol hexakisphosphate kinase 2 promotes cell death of anterior horn cells in the spinal cord of patients with amyotrophic lateral sclerosis.
Autoimmune Diseases
Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles.
Breast Neoplasms
miR-125a-5p impairs the metastatic potential in breast cancer via IP6K1 targeting.
Carcinogenesis
Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice.
Carcinoma
Apo2L/TRAIL induction and nuclear translocation of inositol hexakisphosphate kinase 2 during IFN-beta-induced apoptosis in ovarian carcinoma.
Carcinoma
Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice.
Carcinoma
Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation.
Carcinoma
Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma.
Carcinoma
Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells.
Carcinoma
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics.
Confusion
Multiple aspects of male germ cell development and interactions with Sertoli cells require inositol hexakisphosphate kinase-1.
Fatty Liver
Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases.
Hearing Loss
Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse.
Hyperinsulinism
Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases.
Hypersensitivity
A G-protein ? subunit, AGB1, negatively regulates the ABA response and drought tolerance by down-regulating AtMPK6-related pathway in Arabidopsis.
Infections
Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response.
Infertility
IP6K1 is essential for chromatoid body formation and temporal regulation of Tnp2 and Prm2 expression in mouse spermatids.
Influenza, Human
Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response.
Insulin Resistance
Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis.
Insulin Resistance
Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes.
Insulin Resistance
Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain.
Insulin Resistance
High intensity exercise decreases IP6K1 muscle content & improves insulin sensitivity (SI2*) in glucose intolerant individuals.
Insulin Resistance
Ingestion of lean meat elevates muscle inositol hexakisphosphate kinase 1 protein content independent of a distinct post-prandial circulating proteome in young adults with obesity.
Insulin Resistance
Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis.
Insulin Resistance
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain.
Insulin Resistance
IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution.
Insulin Resistance
Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases.
Insulin Resistance
The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle.
Insulin Resistance
TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway.
Neoplasm Metastasis
Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1.
Neoplasm Metastasis
miR-125a-5p impairs the metastatic potential in breast cancer via IP6K1 targeting.
Neoplasms
Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice.
Neoplasms
Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation.
Neoplasms
Identification of novel Sp1 targets involved in proliferation and cancer by functional genomics.
Neoplasms
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics.
Neoplasms
Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1.
Neoplasms
miR-125a-5p impairs the metastatic potential in breast cancer via IP6K1 targeting.
Neoplasms
Serum miR-1181 and miR-4314 associated with ovarian cancer: MiRNA microarray data analysis for a pilot study.
Neurodegenerative Diseases
Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease.
Obesity
Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis.
Obesity
Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain.
Obesity
Ingestion of lean meat elevates muscle inositol hexakisphosphate kinase 1 protein content independent of a distinct post-prandial circulating proteome in young adults with obesity.
Obesity
Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis.
Obesity
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain.
Obesity
IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution.
Obesity
TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway.
Pancreatitis
Platelet IP6K1 regulates neutrophil extracellular trap-microparticle complex formation in acute pancreatitis.
Pneumonia, Bacterial
Inhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia.
Sarcopenia
The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle.
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