Information on EC 2.7.4.18 - farnesyl-diphosphate kinase

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The expected taxonomic range for this enzyme is: Fusarium fujikuroi

EC NUMBER
COMMENTARY hide
2.7.4.18
-
RECOMMENDED NAME
GeneOntology No.
farnesyl-diphosphate kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + farnesyl diphosphate = ADP + farnesyl triphosphate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:farnesyl-diphosphate phosphotransferase
ADP can also act as donor.
CAS REGISTRY NUMBER
COMMENTARY hide
50936-43-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LiLy-I
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2'-deoxy-adenosine 5'-phosphate + trans-farnesyl diphosphate
2'-deoxyadenosine + trans-farnesyl triphosphate
show the reaction diagram
-
24.1% of the activity with ATP
-
-
?
2'-deoxy-adenosine 5'-triphosphate + trans-farnesyl diphosphate
2'-deoxyadenosine 5'-diphosphate + trans-farnesyl triphosphate
show the reaction diagram
2'-deoxy-uridine 5'-phosphate + trans-farnesyl diphosphate
2'-deoxyuridine + trans-farnesyl triphosphate
show the reaction diagram
-
6% of the activity with ATP
-
-
?
ADP + trans-farnesyl diphosphate
AMP + trans-farnesyl triphosphate
show the reaction diagram
AMP + trans-farnesyl diphosphate
adenosine + trans-farnesyl triphosphate
show the reaction diagram
-
6% of activity compared to ATP
-
-
?
AMP + trans-farnesyl triphosphate
?
show the reaction diagram
AMP + trans-farnesyl triphosphate
ADP + ATP + trans-farnesyl diphosphate
show the reaction diagram
AMP + trans-farnesyl triphosphate
ADP + trans-farnesyl diphosphate
show the reaction diagram
ATP + trans-farnesyl diphosphate
?
show the reaction diagram
-
possibly involved in control of biosynthesis of terpenoids in Gibberella fujikuroi
-
-
?
ATP + trans-farnesyl diphosphate
ADP + trans-farnesyl triphosphate
show the reaction diagram
CMP + trans-farnesyl diphosphate
GDP + trans-farnesyl triphosphate
show the reaction diagram
CTP + trans-farnesyl diphosphate
?
show the reaction diagram
GDP + trans-farnesyl diphosphate
GMP + trans-farnesyl triphosphate
show the reaction diagram
-
8% of activity compared to ATP
-
-
?
GMP + trans-farnesyl diphosphate
CDP + trans-farnesyl triphosphate
show the reaction diagram
-
8.5% of the activity with ATP
-
-
?
UTP + trans-farnesyl diphosphate
?
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
AMP + trans-farnesyl triphosphate
?
show the reaction diagram
ATP + trans-farnesyl diphosphate
?
show the reaction diagram
-
possibly involved in control of biosynthesis of terpenoids in Gibberella fujikuroi
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mn2+
-
substituted for Mg2+ in reaction ATP + trans-farnesyl diphosphate: about 36% of activity compared to Mg2+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
phosphoenolpyruvate
-
weak
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0118
trans-farnesyl triphosphate
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pH 7.6, 35°C, reaction with AMP
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-70°C, liquid N2
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE