Information on EC 2.7.2.6 - formate kinase

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The expected taxonomic range for this enzyme is: Clostridium cylindrosporum

EC NUMBER
COMMENTARY hide
2.7.2.6
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RECOMMENDED NAME
GeneOntology No.
formate kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + formate = ADP + formyl phosphate
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Glyoxylate and dicarboxylate metabolism
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SYSTEMATIC NAME
IUBMB Comments
ATP:formate phosphotransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9026-65-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + acetate
ADP + acetyl phosphate
show the reaction diagram
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formate kinase II
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?
ATP + formate
ADP + formyl phosphate
show the reaction diagram
ATP + propionate
ADP + propionyl phosphate
show the reaction diagram
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formate kinase II
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?
CTP + formate
CDP + formyl phosphate
show the reaction diagram
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formate kinase I: less than 5% as effective as ATP, formate kinase II: 30% as effective as ATP
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r
GTP + formate
GDP + formyl phosphate
show the reaction diagram
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formate kinase I: 20% as effective as ATP, formate kinase II: nearly as effective as ATP
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r
ITP + formate
IDP + formyl phosphate
show the reaction diagram
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formate kinase I: less than 5% as effective as ATP, formate kinase II: 60% as effective as ATP
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r
UTP + formate
UDP + formyl phosphate
show the reaction diagram
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formate kinase I: less than 5% as effective as ATP, formate kinase II: 50% as effective as ATP
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r
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + formate
ADP + formyl phosphate
show the reaction diagram
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the product formyl phosphate serves as formyl donor for the synthesis of formyl coenzyme A in a reaction catalyzed by phosphate acetyltransferase
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?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
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formate kinase I: activates, formate kinase II: 80% as effective as Mn2+ in activation, Km: 2.5 mM
Mn2+
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formate kinase I: can partially replace Mg2+ in activation, formate kinase II: activates, Km: 0.5 mM
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
p-mercuribenzoate
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formate kinase I and II
p-mercuriphenylsulfonic acid
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
400
formate
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formate kinase I, ATP + formate + hydroxylamine
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.8 - 6.9
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formate kinase I
7.2
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formate kinase II
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial, formate kinase I and formate kinase II
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