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Information on EC 2.7.11.9 - Goodpasture-antigen-binding protein kinase
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2.7.11.9 Goodpasture-antigen-binding protein kinaseIUBMB Comments
This serine/threonine kinase specifically binds to and phosphorylates the N-terminal region of the human Goodpasture antigen, which is located on the alpha3 chain of collagen IV and is involved in autoimmune disease.
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Word Map
- 2.7.11.9
- collagen
-
basement
-
lipid-exchange
-
shields
-
lipid-binding
-
glomerular
-
serine-rich
- 25-hydroxycholesterol
-
lipid-sensing
- phosphatidylethanolamine
- sterols
- cholesterol
- phosphatidylcholine
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myelinated
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stard10
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misexpression
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alpha3
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
gpbp-1, stard11, gpbpdelta26, gpbpdelta26/cert, gpbp kinase, goodpasture antigen-binding protein-1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Collagen type IV alpha 3 binding protein
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-
-
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EC 2.7.1.37
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formerly, part transferred
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Goodpasture antigen-binding protein kinase
goodpasture-antigen-binding protein kinase
GPBP
StAR-related lipid transfer protein 11
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-
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StARD11
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-
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START domain-containing protein 11
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goodpasture-antigen-binding protein kinase
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-
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GPBP
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + [Goodpasture antigen-binding protein] = ADP + [Goodpasture antigen-binding phosphoprotein]
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-
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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-
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-
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SYSTEMATIC NAME
IUBMB Comments
ATP:[Goodpasture antigen-binding protein] phosphotransferase
This serine/threonine kinase specifically binds to and phosphorylates the N-terminal region of the human Goodpasture antigen, which is located on the alpha3 chain of collagen IV and is involved in autoimmune disease.
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CAS REGISTRY NUMBER
COMMENTARY
230316-19-5
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
ATP + goodpasture antigen
ADP + phosphorylated goodpasture antigen
phosphorylation in the N-terminal region of the goodpasture antigen
-
?
ATP + goodpasture antigen
ADP + phosphorylated goodpasture antigen
phosphorylation in the N-terminal region of the goodpasture antigen
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-
?
ATP + goodpasture antigen
ADP + phosphorylated goodpasture antigen
enzyme is involved in autoimmune pathogenesis. Enzyme expression is up-regulated in the striated muscle of a Goodpasture patient and in other autoimmune conditions including cutaneous lupus erythematosus, pemphigoid, and lichen planus
-
?
ATP + membrane type IV collagen
ADP + phopshorylated membrane type IV collagen
GPBP serves as transporter of ceramide between the endoplasmic reticulum and the Golgi apparatus. The 91-kDa GPBP splicing variants regulates the levels of 77-kDa GPBP variant, i.e. GPBPDELTA26/CERT, in the extracellular compartment
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-
?
ATP + membrane type IV collagen
ADP + phopshorylated membrane type IV collagen
Goodpasture-antigen binding protein, GPBP, is a nonconventional Ser/Thr kinase for basement membrane type IV collagen. The 77-kDa GPBP is a soluble extracellular protein that interacts with type IV collagen
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-
?
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
the Goodpasture antigen-binding protein is an atypical protein kinase that phosphorylates the Goodpasture auto-antigen, the alpha3 chain of collagen IV
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-
?
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
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-
-
-
?
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
-
-
-
?
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
autophosphorylation via the enzyme's serine/threonine kinase activity that specifically targets a motif in the NC1 domain of the alpha3 chain of type IV collagen, the Good pasture autoantigen, the enzyme is involved in autoimmune processes and disease
-
-
?
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
autophosphorylation via the enzyme's serine/threonine kinase activity that specifically targets a motif in the NC1 domain of the alpha3 chain of type IV collagen, the Good pasture autoantigen
-
-
?
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
-
the Goodpasture antigen-binding protein performs autophosphorylation
-
-
?
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
the Goodpasture antigen-binding protein performs phosphorylation of collagen IV
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-
?
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
the Goodpasture antigen-binding protein performs autophosphorylation
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-
?
additional information
?
-
disruption of the nonvesicular ceramide transport is detrimental to normal embryonic development of somites and brain because of increased apoptosis mediated by the CERT function of GBPB, but not GBPBDELT26, overview
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-
?
additional information
?
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disruption of the nonvesicular ceramide transport is detrimental to normal embryonic development of somites and brain because of increased apoptosis mediated by the CERT function of GBPB, but not GBPBDELT26, overview
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-
?
additional information
?
-
isozyme GPBP also function as ceramide transfer proteins, CERT
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-
?
additional information
?
-
-
isozyme GPBP also function as ceramide transfer proteins, CERT
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-
?
additional information
?
-
isozyme GPBPDELTA26 also functions as ceramide transfer protein, CERT
-
-
?
additional information
?
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isozyme GPBPDELTA26 also functions as ceramide transfer protein, CERT
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-
?
additional information
?
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Goodpasture antigen-binding protein binds to human serum amyloid P component specifically in its physiological conformations, i.e. pentamers and decamers. Collagen IV binds to serum amyloid P and to Goodpasture antigen-binding protein, the latter also binds laminin, binding studies and kinetics, overview
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-
?
additional information
?
-
GPBP-1 targets the GPBP-interacting protein of 130 kDa, GIP130, which binds to myosin and promotes its myofibrillar assembly
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-
?
additional information
?
-
-
GPBP-1 targets the GPBP-interacting protein of 130 kDa, GIP130, which binds to myosin and promotes its myofibrillar assembly
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + goodpasture antigen
ADP + phosphorylated goodpasture antigen
enzyme is involved in autoimmune pathogenesis. Enzyme expression is up-regulated in the striated muscle of a Goodpasture patient and in other autoimmune conditions including cutaneous lupus erythematosus, pemphigoid, and lichen planus
-
?
ATP + membrane type IV collagen
ADP + phopshorylated membrane type IV collagen
GPBP serves as transporter of ceramide between the endoplasmic reticulum and the Golgi apparatus. The 91-kDa GPBP splicing variants regulates the levels of 77-kDa GPBP variant, i.e. GPBPDELTA26/CERT, in the extracellular compartment
-
-
?
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
the Goodpasture antigen-binding protein is an atypical protein kinase that phosphorylates the Goodpasture auto-antigen, the alpha3 chain of collagen IV
-
-
?
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
-
-
-
-
?
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
autophosphorylation via the enzyme's serine/threonine kinase activity that specifically targets a motif in the NC1 domain of the alpha3 chain of type IV collagen, the Good pasture autoantigen, the enzyme is involved in autoimmune processes and disease
-
-
?
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
-
the Goodpasture antigen-binding protein performs autophosphorylation
-
-
?
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
the Goodpasture antigen-binding protein performs phosphorylation of collagen IV
-
-
?
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
the Goodpasture antigen-binding protein performs autophosphorylation
-
-
?
additional information
?
-
disruption of the nonvesicular ceramide transport is detrimental to normal embryonic development of somites and brain because of increased apoptosis mediated by the CERT function of GBPB, but not GBPBDELT26, overview
-
-
?
additional information
?
-
-
disruption of the nonvesicular ceramide transport is detrimental to normal embryonic development of somites and brain because of increased apoptosis mediated by the CERT function of GBPB, but not GBPBDELT26, overview
-
-
?
additional information
?
-
Goodpasture antigen-binding protein binds to human serum amyloid P component specifically in its physiological conformations, i.e. pentamers and decamers. Collagen IV binds to serum amyloid P and to Goodpasture antigen-binding protein, the latter also binds laminin, binding studies and kinetics, overview
-
-
?
additional information
?
-
GPBP-1 targets the GPBP-interacting protein of 130 kDa, GIP130, which binds to myosin and promotes its myofibrillar assembly
-
-
?
additional information
?
-
-
GPBP-1 targets the GPBP-interacting protein of 130 kDa, GIP130, which binds to myosin and promotes its myofibrillar assembly
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
additional information
binding of collagen IV to Goodpasture antigen-binding protein is independent of the presence of Ca2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
human biliverdin reductase
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i.e. hBVR, inhibits GPBP kinase activity, and hBVR decreases GPBP autophosphorylation in a concentration-dependent manner. A 7-residue peptide, KKRILHC281, corresponding to the core of the consensus D(delta)-Box motif in the interacting domain of hBVR, is as effective as the intact 296-residue hBVR polypeptide in inhibiting GPBP kinase activity. The D(delta)-Box motif is a common feature of kinases in the MAPK signaling cascade
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
TNF-alpha
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stimulates the autophosphorylation of Goodpasture antigen-binding protein
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additional information
expression of the Goodpasture antigen-binding protein is induced by tumor necrosis factor
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Carcinoma
Effects of marine sponge extracts on mitogen-activated protein kinase (MAPK/ERK(1,2)) activity in SW-13 human adrenal carcinoma cells.
Carcinoma, Ehrlich Tumor
Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase.
Glioma
Protein kinase translocation following beta-adrenergic receptor activation in C6 glioma cells.
Infections
In vivo and in vitro phosphorylation of DNA-dependent RNA polymerase of Escherichia coli by bacteriophage-T7-induced protein kinase.
Lymphoma
Altered regulation of cyclic AMP-dependent protein kinase in a mouse lymphoma cell line.
Lymphoma
Subunit interaction in cyclic AMP-dependent protein kinase of mutant lymphoma cells.
Neoplasms
Characterization of protein tyrosine kinase activity in murine Leydig tumor cells.
Neoplasms
Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase.
Neuroblastoma
Participation of type II protein kinase A in the retinoic acid-induced growth inhibition of SH-SY5Y human neuroblastoma cells.
Neuroblastoma
Phosphorylation of endogenous proteins by adenosine 3':5'-monophosphate-dependent protein kinase in mouse neuroblastoma cells.
Plasmacytoma
Resolution and general properties of different types of ribosomal protein kinases in mouse plasmocytoma.
Sarcoma
Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase.
Sarcoma, Avian
Cytosolic malic dehydrogenase activity is associated with a putative substrate for the transforming gene product of Rous sarcoma virus.
Sarcoma, Avian
Protein kinase and its regulatory effect on reverse transcriptase activity of Rous sarcoma virus.
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
GPBP-1 accumulates in the cytoplasm of differentiating mouse myoblasts prior to myosin synthesis
brenda
additional information
Goodpasture antigen-binding protein is present in brain amyloid plaques
brenda
additional information
enzyme is preferentially expressed in small vessels and histological structures targeted by natural autoimmune responses including alveolar and glomerular basement membranes
brenda
additional information
isozymes GPBP and GPBPDELTA26 are differentially expressed during development, isozymes function during embryogenesis, GPBP is an important factor for normal skeletal muscle and brain development, overview
brenda
additional information
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isozymes GPBP and GPBPDELTA26 are differentially expressed during development, isozymes function during embryogenesis, GPBP is an important factor for normal skeletal muscle and brain development, overview
brenda
additional information
isozymes GPBP and GPBPDELTA26 are differentially expressed during development, isozymes function during embryogenesis, overview
brenda
additional information
-
isozymes GPBP and GPBPDELTA26 are differentially expressed during development, isozymes function during embryogenesis, overview
brenda
additional information
preferential expression in the histological structures that are targets of common autoimmune responses
brenda
additional information
-
preferential expression in the histological structures that are targets of common autoimmune responses
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
physiological function
metabolism
-
downregulation of GPBP kinase activity by human biliverdin reductase, protein-protein interactions between the two kinases, and regulation of the TNF-alpha/NFkappaB-dependent expression of GPBP by human biliverdin reductase
metabolism
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the enzyme mediates the transport of ceramide from the endoplasmic reticulum to the Golgi site for the synthesis of sphingomyelin
physiological function
Goodpasture antigen-binding protein, GPBP, is a nonconventional Ser/Thr kinase for basement membrane type IV collagen
physiological function
GPBP-1 is a non-conventional kinase that regulates glomerular basement membrane collagen organization. It targets GIP130, a new myosin-binding protein, and regulates myofibrillogenesis in cultured myoblasts. GPBP-1 is a kinase for structural protein organization at both intracellular and extracellular compartments
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). B0EAN0_ENTDS
Entamoeba dispar (strain ATCC PRA-260 / SAW760)
122
0
13894
TrEMBL
other Location (Reliability: 4)
B0EBK9_ENTDS
Entamoeba dispar (strain ATCC PRA-260 / SAW760)
470
0
54482
TrEMBL
other Location (Reliability: 2)
E0V9Z6_PEDHC
225
0
25642
TrEMBL
Secretory Pathway (Reliability: 5)
B7PFK0_IXOSC
689
0
77977
TrEMBL
other Location (Reliability: 2)
A0A161M2M1_TRIIF
118
0
13466
TrEMBL
other Location (Reliability: 1)
A0A0B2QS91_GLYSO
203
0
22410
TrEMBL
other Location (Reliability: 1)
B7Q875_IXOSC
728
0
82556
TrEMBL
other Location (Reliability: 1)
B0EM87_ENTDS
Entamoeba dispar (strain ATCC PRA-260 / SAW760)
252
0
29906
TrEMBL
other Location (Reliability: 1)
B7P4J3_IXOSC
551
0
62730
TrEMBL
other Location (Reliability: 2)
E0VJA4_PEDHC
794
0
91568
TrEMBL
other Location (Reliability: 1)
A0A161M2R5_TRIIF
144
0
16386
TrEMBL
other Location (Reliability: 4)
B0EAY5_ENTDS
Entamoeba dispar (strain ATCC PRA-260 / SAW760)
252
0
29934
TrEMBL
other Location (Reliability: 1)
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoprotein
-
Goodpasture antigen-binding protein performs autophosphorylation
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
I439A/W588A
site-directed mutagenesis, the mutant shows reduced binding of serum amyloid P
N460A/Y461A
site-directed mutagenesis, the mutant shows unaltered binding of serum amyloid P
P500G/A501Q
site-directed mutagenesis, the mutant binding to serum amyloid P is abolished
V498A/W499A
site-directed mutagenesis, the mutant shows unaltered binding of serum amyloid P
Y461A/F462A
site-directed mutagenesis, the mutant shows reduced binding of serum amyloid P
additional information
additional information
construction of antisense oligonucleotide-mediated loss-of-function and synthetic mRNA-based gain-of-function mutants. The loss-of-function phenotype is linked to cell death, evident primarily in the muscle of the somites, extensive loss of myelinated tracks, and brain edema, phenotype, overview
additional information
-
construction of antisense oligonucleotide-mediated loss-of-function and synthetic mRNA-based gain-of-function mutants. The loss-of-function phenotype is linked to cell death, evident primarily in the muscle of the somites, extensive loss of myelinated tracks, and brain edema, phenotype, overview
additional information
immobilization of Goodpasture antigen-binding protein by human serum amyloid P component binding from solution and in plasma, overview. Serum amyloid P associates in the blood with a 37-kDa GPBP fragment containing the N-terminal region and the middle domain
additional information
gpbp-1-/- mice and Tg-hGPBP-1 animals do not display any obvious morphological phenotype, gpbp-1-/- mice also do not show a functional phenotype, whereas Tg-hGPBP-1 mice display reduced endurance that is not attributable to mitochondrial alterations
additional information
-
gpbp-1-/- mice and Tg-hGPBP-1 animals do not display any obvious morphological phenotype, gpbp-1-/- mice also do not show a functional phenotype, whereas Tg-hGPBP-1 mice display reduced endurance that is not attributable to mitochondrial alterations
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant FLAG-tagged Goodpasture antigen-binding protein from Escherichia coli strain BL21(DE3) by affinity chromatography
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA sequence determination and analysis, a TNF-responsive transcription unit that locates the enzyme in the signalling cascade of TNF, regulation of transcription, e.g. by tumor necrosis factor, via cooperation in a bidirectional transcription complex with the gene encoding the DNA polymerase kappa, NFkappaB, and a 140-bp promoter with a Sp1 site and a TATA-like element, promoter analysis, overview
expression of FLAG-tagged Goodpasture antigen-binding protein in Escherichia coli strain BL21(DE3)
expression of FLAG-tagged Goodpasture antigen-binding protein in HEK-293A cells
-
gene COL4A3BP, DNA and amino acid sequence determinatio and analysis, gene COL4A3BP bears an alternative canonical translation initiation site, iMet, that extends the open reading frame of the 91-kDa polypeptide upstream by 45 residues, expression of FLAG-tagged GPBP in HeLa cells, two splicing variants GPBP and GPBPDELTA26/CERT. Native GPBP polypeptides of 91 kDa and 120 kDa are expressed insolubly associated with cellular membranes, whereas native GPBPDELTA26/CERT polypeptide of 77 kDa is expressed soluble in the cytoplasm, overview
gene COL4A3BP, located on chromosome 5, the gene product is alternatively spliced producing two protein isozymes: GPBP and GPBPDELTA26, DNA and amino acid sequence determination and analysis, expression of wild-type and mutant isozyme GPBP in HEK-293 cells
gene COL4A3BP, located on chromosome 5, the gene product is alternatively spliced producing two protein isozymes: GPBP and GPBPDELTA26, DNA and amino acid sequence determination and analysis, expression of wild-type and mutant isozyme GPBPDELTA26 in HEK-293 cells
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
TNF-alpha-mediated transcriptional activation of GPBP, not affected by human biliverdin reductase
-
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kawai, J.; Shinagawa, A.; Shibata, K.; Yoshino, M.; Itoh, M.; et al.
Functional annotation of a full-length mouse cDNA collection
Nature
409
685-690
2001
Mus musculus (Q9EQG9)
brenda
Raya, A.; Revert-Ros, F.; Martinez-Martinez, P.; Navarro, S.; Rosello, E.; et al.
Goodpasture antigen-binding protein, the kinase that phosphorylates the goodpasture antigen, is an alternatively spliced variant implicated in autoimmune pathogenesis
J. Biol. Chem.
275
40392-40399
2000
Bos taurus (Q9GKI7), Homo sapiens (Q9Y5P4), Homo sapiens, Mus musculus (Q9EQG9)
brenda
Raya, A.; Revert, F.; Navarro, S.; Saus, J.
Characterization of a novel type of serine/threonine kinase that specifically phosphorylates the human goodpasture antigen
J. Biol. Chem.
274
12642-12649
1999
Homo sapiens (Q9Y5P4)
brenda
Granero, F.; Revert, F.; Revert-Ros, F.; Lainez, S.; Martinez-Martinez, P.; Saus, J.
A human-specific TNF-responsive promoter for Goodpasture antigen-binding protein
FEBS J.
272
5291-5305
2005
Homo sapiens (Q9Y5P4)
brenda
Granero-Molto, F.; Sarmah, S.; ORear, L.; Spagnoli, A.; Abrahamson, D.; Saus, J.; Hudson, B.G.; Knapik, E.W.
Goodpasture antigen-binding protein and its spliced variant, ceramide transfer protein, have different functions in the modulation of apoptosis during zebrafish development
J. Biol. Chem.
283
20495-20504
2008
Danio rerio (Q5M7Y0), Danio rerio
brenda
Revert, F.; Ventura, I.; Martinez-Martinez, P.; Granero-Molto, F.; Revert-Ros, F.; Macias, J.; Saus, J.
Goodpasture antigen-binding protein is a soluble exportable protein that interacts with type IV collagen: identification of novel membrane-bound isoforms
J. Biol. Chem.
283
30246-30255
2008
Homo sapiens (Q9Y5P4)
brenda
Mencarelli, C.; Hammels, C.; Van Den Broeck, J.; Losen, M.; Steinbusch, H.; Revert, F.; Saus, J.; Hopkins, D.A.; De Baets, M.H.; Steinbusch, H.W.; Martinez-Martinez, P.
The expression of the Goodpasture antigen-binding protein (ceramide transporter) in adult rat brain
J. Chem. Neuroanat.
38
97-105
2009
Rattus norvegicus
brenda
Miralem, T.; Gibbs, P.E.; Revert, F.; Saus, J.; Maines, M.D.
Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression
J. Biol. Chem.
285
12551-12558
2010
Homo sapiens
brenda
Revert-Ros, F.; Lopez-Pascual, E.; Granero-Molto, F.; Macias, J.; Breyer, R.; Zent, R.; Hudson, B.G.; Saadeddin, A.; Revert, F.; Blasco, R.; Navarro, C.; Burks, D.; Saus, J.
Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130)
J. Biol. Chem.
286
35030-35043
2011
Mus musculus (Q9EQG9), Mus musculus
brenda
Mencarelli, C.; Bode, G.H.; Losen, M.; Kulharia, M.; Molenaar, P.C.; Veerhuis, R.; Steinbusch, H.W.; De Baets, M.H.; Nicolaes, G.A.; Martinez-Martinez, P.
Goodpasture antigen-binding protein/ceramide transporter binds to human serum amyloid P-component and is present in brain amyloid plaques
J. Biol. Chem.
287
14897-14911
2012
Homo sapiens (Q9Y5P4)
brenda
Hanada, K.
Co-evolution of sphingomyelin and the ceramide transport protein CERT
Biochim. Biophys. Acta
1841
704-719
2014
Homo sapiens
brenda
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Release 2023.1 (January 2023)
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