Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Arthritis
Adeno-associated virus vector-mediated anti-angiogenic gene therapy for collagen-induced arthritis in mice.
Carcinoma
Counterselection and co-delivery of transposon and transposase functions for Sleeping Beauty-mediated transposition in cultured mammalian cells.
Carcinoma, Embryonal
Comparative analysis of retroviral vector expression in mouse embryonal carcinoma cells.
Carcinoma, Embryonal
Two distinct sequence elements mediate retroviral gene expression in embryonal carcinoma cells.
Carcinoma, Hepatocellular
Specific inhibition of hepatitis C virus replication by cyclosporin A.
Cholera
Greenhouse and field cultivations of antigen-expressing potatoes focusing on the variability in plant constituents and antigen expression.
Cystic Fibrosis
Retrovirus-mediated gene transfer to cystic fibrosis airway epithelial cells: effect of selectable marker sequences on long-term expression.
Cystic Fibrosis
Selection for precise chromosomal targeting of a dominant marker by homologous recombination.
Cysts
Stable transfection of Acanthamoeba castellanii.
Dengue
Triaryl pyrazoline compound inhibits flavivirus RNA replication.
Diphtheria
A Universal Positive-Negative Selection System for Gene Targeting in Plants Combining an Antibiotic Resistance Gene and Its Antisense RNA.
Diphtheria
Negative selection with the Diphtheria toxin A fragment gene improves frequency of Cre-mediated cassette exchange in ES cells.
Foot-and-Mouth Disease
Construction of self-replicating subgenomic West Nile virus replicons for screening antiviral compounds.
Foot-and-Mouth Disease
High-titer bicistronic retroviral vectors employing foot-and-mouth disease virus internal ribosome entry site.
Foot-and-Mouth Disease
Tissue culture independent transformation of the forage crop sunnhemp (Crotalaria juncea L.): an easy method towards generation of transgenics.
Hepatitis C
Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication.
Herpes Simplex
A calcium ionophore-inducible cellular promoter is highly active and has enhancerlike properties.
Herpes Simplex
A dominant positive and negative selectable gene for use in mammalian cells.
Herpes Simplex
Characterization and transduction of a retroviral vector encoding human interleukin-4 and herpes simplex virus-thymidine kinase for glioma tumor vaccine therapy.
Herpes Simplex
Comparative analysis of retroviral vector expression in mouse embryonal carcinoma cells.
Herpes Simplex
E1A control of gene expression is mediated by sequences 5' to the transcriptional starts of the early viral genes.
Herpes Simplex
Germline transmission of exogenous genes in the chicken.
Herpes Simplex
Identification of genes induced by factor deprivation in hematopoietic cells undergoing apoptosis using gene-trap mutagenesis and site-specific recombination.
Herpes Simplex
Nonmyeloablative immunosuppressive regimen prolongs In vivo persistence of gene-modified autologous T cells in a nonhuman primate model.
Herpes Simplex
Recombination between a herpes simplex virus type 1 vector deleted for immediate early gene 3 and the infected cell genome.
Herpes Simplex
Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells.
Herpes Simplex
Retrovirus-mediated transfer of the herpes simplex type I thymidine kinase gene in alloreactive T lymphocytes.
Herpes Simplex
Secretion of enzymatically active human renin from mammalian cells using an avian retroviral vector.
Herpes Simplex
T lymphocyte transduction with herpes simplex virus-thymidine kinase (HSV-tk) gene: comparison of four different infection protocols.
Herpes Simplex
Targeting efficiency of a-1,3-galactosyl transferase gene in pig fetal fibroblast cells.
HIV Infections
Peripheral expansion of pre-existing mature T cells is an important means of CD4+ T-cell regeneration HIV-infected adults.
Infections
Agrobacterium-mediated transformation of white mustard (Sinapis alba L.) and regeneration of transgenic plants.
Infections
Application of CRISPR/Cas9-Mediated Gene Editing in Tomato.
Infections
Autologous transplantation of canine long-term marrow culture cells genetically marked by retroviral vectors.
Infections
Co-packaging of non-vector RNAs generates replication-defective retroviral vector particles: a novel approach for blocking retrovirus replication.
Infections
Coincident sequence-specific RNA degradation of linked transgenes in the plant genome.
Infections
E- vectors: development of novel self-inactivating and self-activating retroviral vectors for safer gene therapy.
Infections
Efficient gene transfer into primary murine lymphocytes obviating the need for drug selection.
Infections
Gene transfer into hematopoietic progenitor cells from normal and cyclic hematopoietic dogs using retroviral vectors.
Infections
Genetic improvement of Chinese cabbage for salt and drought tolerance by constitutive expression of a B. napus LEA gene.
Infections
Klebsiella neonatal injections: mechanism of broadening aminoglycoside resistance.
Infections
Long-term transplantation of canine keratinocytes made resistant to G418 through retrovirus-mediated gene transfer.
Infections
Prevalence of genes for aminoglycoside-modifying enzymes in Staphylococcus epidermidis isolates from orthopedic postsurgical and implant-related infections.
Infections
Spleen necrosis virus, an avian retrovirus, can infect primate cells.
Infections
T lymphocyte transduction with herpes simplex virus-thymidine kinase (HSV-tk) gene: comparison of four different infection protocols.
Infections
Tissue-specific and ectopic expression of genes introduced into transgenic mice by retroviruses.
Infections
Wild-type p53 suppresses the malignant phenotype in breast cancer cells containing mutant p53 alleles.
Leukemia
Chromosomal position effects on AAV-mediated gene targeting.
Leukemia
Gene activation mediated by protein kinase C in human macrophage and teratocarcinoma cells expressing aminoglycoside phosphotransferase activity.
Leukemia
Gene transfer into fetal baboon hematopoietic progenitor cells.
Leukemia
Highly efficient gene transfer into preterm CD34 hematopoietic progenitor cells.
Leukemia
Increased functional expression of transgene in primary human lymphocytes using retroviral vectors modified with IRES and splicing motifs.
Leukemia
Introduction of new genetic material into human myeloid leukemic blast stem cells by retroviral infection.
Leukemia
Mutational library analysis of selected amino acids in the receptor binding domain of envelope of Akv murine leukemia virus by conditionally replication competent bicistronic vectors.
Leukemia
Pseudotype formation of murine leukemia virus with the G protein of vesicular stomatitis virus.
Leukemia
Recombinant adeno-associated virus-mediated gene transfer into human leukemia cell lines.
Leukemia
Retroviral gene transfer in autologous bone marrow transplantation for adult acute leukemia.
Leukemia
Retroviral recombination rates do not increase linearly with marker distance and are limited by the size of the recombining subpopulation.
Leukemia
Spleen necrosis virus, an avian retrovirus, can infect primate cells.
Leukemia
Spontaneous silencing of humanized green fluorescent protein (hGFP) gene expression from a retroviral vector by DNA methylation.
Leukemia
The expression of neomycin phosphotransferase in human promyelocytic leukemia cells (HL60) delays their differentiation.
Leukemia, Myeloid, Acute
Introduction of new genetic material into human myeloid leukemic blast stem cells by retroviral infection.
Lymphoma, Large B-Cell, Diffuse
Overexpression of manganese superoxide dismutase promotes survival in cell lines after doxorubicin treatment.
Malaria
Rapid positive selection of stable integrants following transfection of Plasmodium falciparum.
Mastitis
Methicillin and aminoglycoside resistance in Staphylococcus aureus isolates from bovine mastitis and sequence analysis of their mecA genes.
Melanoma
Overexpression of manganese superoxide dismutase promotes survival in cell lines after doxorubicin treatment.
Melanoma
The influence of the oncogene N-ras on cell cycle delay in a human melanoma cell line with reduced radioresistance.
Meningioma
A novel model of intracranial meningioma in mice using luciferase-expressing meningioma cells. Laboratory investigation.
Mouth Diseases
Construction of self-replicating subgenomic West Nile virus replicons for screening antiviral compounds.
Mouth Diseases
Tissue culture independent transformation of the forage crop sunnhemp (Crotalaria juncea L.): an easy method towards generation of transgenics.
Neoplasms
A simple procedure for the expression of genes in transgenic soybean callus tissue.
Neoplasms
Characterization of human tumor cell lines transduced with the cDNA encoding either tumor necrosis factor alpha (TNF-a) or interleukin-2 (IL-2).
Neoplasms
Constitutive expression of the c-fos protooncogene in murine keratinocytes: potentiation of the mitogenic response to insulin-like growth factor 1.
Neoplasms
Factors Affecting the Level of Kanamycin Resistance in Transformed Sunflower Cells.
Neoplasms
Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo.
Neoplasms
Flt3 ligand antitumor activity in a murine breast cancer model: a comparison with granulocyte-macrophage colony-stimulating factor and a potential mechanism of action.
Neoplasms
Gene therapy of rat 9L gliosarcoma tumors by transduction with selectable genes does not require drug selection.
Neoplasms
Gene transfer into peanut (Arachis hypogaea L.) by Agrobacterium tumefaciens.
Neoplasms
Generation of potent anti-tumor immunity in mice by interleukin-12-secreting dendritic cells.
Neoplasms
IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis.
Neoplasms
Regulation of T-helper-1 versus T-helper-2 activity and enhancement of tumor immunity by combined DNA-based vaccination and nonviral cytokine gene transfer.
Neoplasms
The development of gene therapy for the treatment of cancer.
Neoplasms
The initiation of de novo methylation of foreign DNA integrated into a mammalian genome is not exclusively targeted by nucleotide sequence.
Neoplasms
Transformation of Stylosanthes spp. using Agrobacterium tumefaciens.
Neoplasms
Use of T-cell growth factors (interleukins 2, 4, 7, 10, and 12) in the evaluation of T-cell reactivity to melanoma.
Neuroblastoma
Immunomodulatory effects of human neuroblastoma cells transduced with a retroviral vector encoding interleukin-2.
Neuroblastoma
The aminoglycoside G418 suppresses muscarinic receptor-activated calcium release in stably transfected murine N1E-115 neuroblastoma cells.
Pancreatic Neoplasms
Active immunotherapy of pancreatic cancer with tumor cells genetically engineered to secrete multiple cytokines.
Papilloma
A bacteriophage transcription terminator permits the cloning of a mammalian expression vector carrying the human preprorenin gene in E. coli.
Papilloma
Efficient selection for high-expression transfectants with a novel eukaryotic vector.
Sarcoma
Q vectors, bicistronic retroviral vectors for gene transfer.
Sarcoma, Avian
Efficient gene expression in mammalian cells from a dicistronic transcriptional unit in an improved retroviral vector.
Starvation
Pyruvate is synthesized by two pathways in pea bacteroids with different efficiencies for nitrogen fixation.
Teratocarcinoma
Gene activation mediated by protein kinase C in human macrophage and teratocarcinoma cells expressing aminoglycoside phosphotransferase activity.
Tuberculosis
Rv3168 phosphotransferase activity mediates kanamycin resistance in Mycobacterium tuberculosis.
Vaccinia
Quantitative assay of recombinant vaccinia virus-encoded neomycin phosphotransferase in infected eukaryotic cell lysates.
Vaccinia
Use of the gene encoding neomycin phosphotransferase II to convect linked markers into the vaccinia virus genome.
Vesicular Stomatitis
Retrovirus-mediated transduction of porcine keratinocytes in organ culture.
Virus Diseases
Construction of a clonable, infectious, and tumorigenic mouse mammary tumor virus provirus and a derivative genetic vector.
Virus Diseases
Expression of phosphoenolpyruvate carboxykinase (PEPCK) chimeras in renal epithelial cells. Retention of appropriate physiological responsiveness using enhancerless retroviral vectors.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Doi, O.; Ogura, M.; Tanaka, N.; Umezawa, H.
Inactivation of kanamycin, neomycin, and streptomycin by enzymes obtained in cells of Pseudomonas aeruginoa
Appl. Microbiol.
16
1276-1281
1968
Pseudomonas aeruginosa
brenda
Doi, O.; Miyamoto, M.; Tanaka, N.; Umezawa, H.
Inactivation and phosphorylation of kanamycin by drug-resistant Staphylococcus aureus
Appl. Microbiol.
16
1282-1284
1968
Staphylococcus aureus
brenda
Ozanne, B.; Benveniste, R.; Tipper, D.; Davies, J.
Aminoglycoside antibiotics: inactivation by phosphorylation in Escherichia coli carrying R factors
J. Bacteriol.
100
1144-1146
1969
Escherichia coli
brenda
Reiss, B.; Sprengel, R.; Will, H.; Schaller, H.
A new sensitive method for qualitative and quantitative assay of neomycin phosphotransferase in crude cell extracts
Gene
30
211-218
1984
Escherichia coli, Platyrrhini, Mus musculus
brenda
Haas, M.J.; Dowding, J.E.
Aminoglycoside-modifying enzymes
Methods Enzymol.
43
611-627
1975
Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Pseudomonas aeruginosa Ps49
brenda
Nastri, H.G.; Algranati, I.D.
Effect of polyamines on plasmid-mediated kanamycin resistance and kanamycin phosphotransferase gene expression in Escherichia coli
Cell. Mol. Biol.
42
711-717
1996
Escherichia coli
brenda
McKay, G.A.; Wright, G.D.
Catalytic mechanism of enterococcal kanamycin kinase (APH(3')-IIIa): viscosity, thio, and solvent isotope effects support a Theorell-Chance mechanism
Biochemistry
35
8680-8685
1996
Escherichia coli
brenda
dos Santos, W.G.; Buck, G.A.
Simultaneous stable expression of neomycin phosphotransferase and green fluorescence protein genes in Trypanosoma cruzi
J. Parasitol.
86
1281-1288
2000
Escherichia coli
brenda
Rashid, M.B.; Mensa-Wilmot, K.
Novel kanamycin/neomycin phosphotransferase cassette increases transformation efficiency in E. coli
Biotechniques
28
90-94
2000
Escherichia coli
brenda
Van Houdt, H.; Kovarik, A.; Van Montagu, M.; Depicker, A.
Cross-talk between posttranscriptionally silenced neomycin phosphotransferase II transgenes
FEBS Lett.
467
41-46
2000
Escherichia coli
brenda
Kromer, W.J.; Bailey, J.E.
Expression of the membrane protein glycophorin A as a fusion with the antibiotic resistance protein neomycin phosphotransferase II
Biotechnol. Bioeng.
57
238-244
1998
Escherichia coli
brenda
Heng, B.C.; Cao, T.
Immunoliposome-mediated delivery of neomycin phosphotransferase for the lineage-specific selection of differentiated/committed stem cell progenies: potential advantages over transfection with marker genes, fluorescence-activated and magnetic affinity cell-sorting
Med. Hypotheses
65
334-336
2005
Homo sapiens
brenda
Wang, Y.; Kasper, S.; Yuan, J.; Jin, R.J.; Zhang, J.; Ishii, K.; Wills, M.L.; Hayward, S.W.; Matusik, R.J.
Androgen-dependent prostate epithelial cell selection by targeting ARR2PBneo to the LPB-tag model of prostate cancer
Lab. Invest.
86
1074-1088
2006
Mus musculus
brenda
Shakya, T.; Wright, G.D.
Nucleotide selectivity of antibiotic kinases
Antimicrob. Agents Chemother.
54
1909-1913
2010
Enterococcus casseliflavus
brenda
Elizarov, S.M.; Alekseeva, M.G.; Novikov, F.N.; Chilov, G.G.; Maslov, D.A.; Shtil, A.A.; Danilenko, V.N.
Identification of phosphorylation sites in aminoglycoside phosphotransferase VIII from Streptomyces rimosus
Biochemistry (Moscow)
77
1258-1265
2012
Streptomyces rimosus, Streptomyces rimosus ATCC 10970
brenda
Leban, N.; Kaplan, E.; Chaloin, L.; Godreuil, S.; Lionne, C.
Kinetic characterization and molecular docking of novel allosteric inhibitors of aminoglycoside phosphotransferases
Biochim. Biophys. Acta
1861
3464-3473
2017
Enterococcus faecalis (P0A3Y5)
brenda
Das, A.; Shukla, A.; Thakur, S.; Rathore, M.; Singh, Narendra
Estimation of neomycin phosphotransferase-II (NPT-II) protein in vegetative and reproductive tissues of transgenic chickpea (Cicer arietinum L.) and biosafety perspectives
J. Plant Biochem. Biotechnol.
29
568-570
2020
Escherichia coli
-
brenda
Numata, K.; Horii, Y.; Motoda, Y.; Hirai, N.; Nishitani, C.; Watanabe, S.; Kigawa, T.; Kodama, Y.
Direct introduction of neomycin phosphotransferase II protein into apple leaves to confer kanamycin resistance
Plant Biotechnol.
33
403-407
2016
Escherichia coli
brenda