Reference on EC 2.7.1.67 - 1-phosphatidylinositol 4-kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Walker, D.H.; Dougherty, N.; Pike, L.J.
Purification and characterization of a phosphatidylinositol kinase from A431 cells
Biochemistry
27
6504-6511
1988
Homo sapiens
Colodzin, M.; Kennedy, E.P.
Biosynthesis of diphosphoinositide in brain
J. Biol. Chem.
240
3771-3780
1965
Rattus norvegicus
Kai, M.; White, G.L.; Hawthorne, J.N.
The phosphatidylinositol kinase of rat brain
Biochem. J.
101
328-337
1966
Rattus norvegicus
Moritz, A.; Westerman, J.; De Graan, P.N.E.; Wirtz, K.W.A.
Phosphatidylinositol 4-kinase and phosphatidylinositol-4-phosphate 5-kinase from bovine brain membranes
Methods Enzymol.
209
202-211
1992
Bos taurus
Sommarin, M.; Sandelius, A.S.
Phosphatidylinositol and phosphatidylinositolphosphate kinases in plant plasma membranes
Biochim. Biophys. Acta
958
268-278
1988
Triticum aestivum
-
Cooper, P.H.; Hawthorne, J.N.
Phosphatidylinositol kinase and diphosphoinositide kinase of rat kidney cortex: properties and subcellular localization
Biochem. J.
160
97-105
1976
Rattus norvegicus
Tuazon, P.T.; Traugh, J.A.
Phosphatidylinositol kinases from rabbit reticulocytes
Methods Enzymol.
141
210-222
1987
Oryctolagus cuniculus
Carman, G.M.; Belunis, C.J.; Nickels, J.T.
Phosphatidylinositol 4-kinase from yeast
Methods Enzymol.
209
183-189
1992
Saccharomyces cerevisiae, Saccharomyces cerevisiae ade5 MATa
Vogel, S.; Hoppe, J.
Polyamines stimulate the phosphorylation of phosphatidylinositol in membranes from A431 cells
Eur. J. Biochem.
154
253-257
1986
Homo sapiens
Li, Y.S.; Porter, F.D.; Hoffman, R.M.; Deuel, T.F.
Separation and identification of two phosphatidylinositol 4-kinase activities in bovine uterus
Biochem. Biophys. Res. Commun.
160
202-209
1989
Bos taurus
Graziani, A.; Ling, L.E.; Endemann, G.; Carpenter, C.L.; Cantley, L.C.
Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes
Biochem. J.
284
39-45
1992
Homo sapiens
-
Nishioka, H.; Sawa, T.; Hamada, M.; Shimura, N.; Imoto, M.; Umezawa, K.
Inhibition of phosphatidylinositol kinase by toyocamycin
J. Antibiot.
43
1586-1589
1990
Homo sapiens
Suga, K.; Kambayashi, J.; Tsujinaka, T.; Sakon, M.; Mori, T.
Properties of phosphatidylinositol kinase of human platelets
Biochem. Int.
15
769-777
1987
Homo sapiens
Yang, W.; Bukhardt, W.; Cavallius, J.; Merrick, W.C.; Boss, W.F.
Purification and characterization of a phosphatidylinositol 4-kinase activator in carrot cells
J. Biol. Chem.
268
392-398
1993
Daucus carota
Husebye, E.S.; Flatmark, T.
Phosphatidylinositol kinase of bovine adrenal chromaffin granules: kinetic properties and inhibition by low concentrations of Ca2+
Biochim. Biophys. Acta
968
261-265
1988
Bos taurus
McKenzie, M.A.; Carman, G.M.
Membrane-associated phosphatidylinositol kinase from Saccharomyces cerevisiae
J. Bacteriol.
156
421-423
1983
Saccharomyces cerevisiae
Flanagan, C.A.; Thorner, J.
Purification and characterization of a soluble phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae
J. Biol. Chem.
267
24117-24125
1992
Saccharomyces cerevisiae
Nickels, J.T.; Buxeda, R.J.; Carman, G.M.
Purification, characterization, and kinetic analysis of a 55-kDa form of phosphatidylinositol 4-kinase from Saccharomyces cerevisiae
J. Biol. Chem.
267
16297-16304
1992
Saccharomyces cerevisiae
Endemann, G.; Dunn, S.N.; Cantley, L.C.
Bovine brain contains two types of phosphatidylinositol kinase
Biochemistry
26
6845-6852
1987
Bos taurus
Porter, F.D.; Li, Y.S.; Deuel, T.F.
Purification and characterization of a phosphatidylinositol 4-kinase from bovine uteri
J. Biol. Chem.
263
8989-8995
1988
Bos taurus
O'Shea, J.J.; Harford, J.B.; Klausner, R.D.
Identification and characterization of the phosphatidylinositol kinase in membranes of murine T lymphocytes
J. Immunol.
137
971-976
1986
Mus musculus
Collins, C.A.; Wells, W.W.
Identification of phosphatidylinositol kinase in rat liver lysosomal membranes
J. Biol. Chem.
258
2130-2134
1983
Rattus norvegicus
Lundberg, G.A.; Jergil, B.; Sundler, R.
Subcellular localization and enzymatic properties of rat liver phosphatidylinositol-4-phosphate kinase
Biochim. Biophys. Acta
846
379-387
1985
Rattus norvegicus
Hou, W.M.; Zhang, Z.L.; Tai, H.H.
Purification and characterization of phosphatidylinositol kinase from porcine liver microsomes
Biochim. Biophys. Acta
959
67-75
1988
Sus scrofa
Saltiel, A.R.; Fox, J.A.; Sherline, P.; Sahyoun, N.; Cuatrecasas, P.
Purification of phosphatidylinositol kinase from bovine brain myelin
Biochem. J.
241
759-763
1987
Bos taurus
Buckley, J.T.
Properties of human erythrocyte phosphatidylinositol kinase and inhibition by adenosine, ADP and related compounds
Biochim. Biophys. Acta
498
1-9
1977
Homo sapiens
Jenkins, G.H.; Subrahmanyam, G.; Anderson, R.A.
Purification and reconstitution of phosphatidylinositol 4-kinase from human erythrocytes
Biochim. Biophys. Acta
1080
11-18
1991
Homo sapiens
Buxeda, R.J.; Nickels, J.T.; Belunis, C.J.; Carman, G.M.
Phosphatidylinositol 4-kinase from Saccharomyces cerevisiae. Kinetic analysis using Triton X-100/phosphatidylinositol-mixed micelles
J. Biol. Chem.
266
13859-13865
1991
Saccharomyces cerevisiae
Del Vecchio, R.L.; Pilch, P.F.
Phosphatidylinositol 4-kinase is a component of glucose transporter (GLUT 4)-containing vesicles
J. Biol. Chem.
266
13278-13283
1991
Rattus norvegicus
Wetzker, R.; Klinger, R.; Hsuan, J.; Fry, M.J.; Kauffmann-Zeh, A.; Mller, E.; Frunder, H.; Waterfield, M.
Purification and characterization of phosphatidylinositol 4-kinase from human erythrocyte membranes
Eur. J. Biochem.
200
179-185
1991
Homo sapiens
Scholz, G.; Barritt, G.J.; Kwok, F.
Purification and chemical modification of a phosphatidylinositol kinase from sheep brain
Eur. J. Biochem.
201
249-255
1991
Ovis aries
Saha, A.K.; Dowling, J.N.; Mukhopadhyay, N.K.; Glew, R.H.
Legionella micdadei protein kinase catalyzes phosphorylation of tubulin and phosphatidylinositol
J. Bacteriol.
171
5103-5110
1989
Tatlockia micdadei
Husebye, E.S.; Letcher, A.J.; Lander, D.J.; Flatmark, T.
Purification and kinetic properties of a membrane-bound phosphatidylinositol kinase of the bovine adrenal medulla
Biochim. Biophys. Acta
1042
330-337
1990
Bos taurus
Kanoh, H.; Banno, Y.; Hirata, M.; Nozawa, Y.
Partial purification and characterization of phosphatidylinositol kinases from human platelets
Biochim. Biophys. Acta
1046
120-126
1990
Homo sapiens
Yamakawa, A.; Takenawa, T.
Purification and characterization of membrane-bound phosphatidylinositol kinase from rat brain
J. Biol. Chem.
263
17555-17560
1988
Rattus norvegicus
Belunis, C.J.; Bae-Lee, M.; Kelley, M.J.; Carman, G.M.
Purification and characterization of phosphatidylinositol kinase from Saccharomyces cerevisiae
J. Biol. Chem.
263
18897-18903
1988
Saccharomyces cerevisiae
Steinert, P.; Wissing, J.B.; Wagner, K.G.
Manganese-stimulated phosphatidylinositol 4-kinase from Dunaliella parva: purification and characterization
Plant Sci.
101
105-114
1994
Dunaliella parva
-
Okpodu, C.M.
Characterization of a nuclear phosphatidylinositol 4-kinase in carrot suspension culture cells
Plant Physiol. Biochem.
37
473-480
1999
Daucus carota
-
Heilmeyer, L.Jr.; Vereb, G.Jr.; Vereb, G.; Kakuk, A.; Szivak, I.
Mammalian phosphatidylinositol 4-kinases
IUBMB Life
55
59-65
2003
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
Fernandis, A.Z.; Subrahmanyam, G.
Concanavalin A modulates tyrosine phosphorylation and activation of a type II phosphatidylinositol 4-kinase in rat splenic lymphocytes
Mol. Immunol.
35
935-941
1998
Rattus norvegicus
Suer, S.; Sickmann, A.; Meyer, H.E.; Herberg, F.W.; Heilmeyer, L.M., Jr.
Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites
Eur. J. Biochem.
268
2099-2106
2001
Homo sapiens (Q9UBF8), Homo sapiens
Waugh, M.G.; Minogue, S.; Anderson, J.S.; Balinger, A.; Blumenkrantz, D.; Calnan, D.P.; Cramer, R.; Hsuan, J.J.
Localization of a highly active pool of type II phosphatidylinositol 4-kinase in a p97/valosin-containing-protein-rich fraction of the endoplasmic reticulum
Biochem. J.
373
57-63
2003
Homo sapiens
Zhao, X.H.; Bondeva, T.; Balla, T.
Characterization of recombinant phosphatidylinositol 4-kinase beta reveals auto- and heterophosphorylation of the enzyme
J. Biol. Chem.
275
14642-14648
2000
Bos taurus
Okpodu, C.M.; Gross, W.; Burkhart, W.; Boss, W.F.
Purification and Characterization of a Soluble Phosphatidylinositol 4-Kinase from Carrot Suspension Culture Cells
Plant Physiol.
107
491-500
1995
Daucus carota
Zhao, X.; Varnai, P.; Tuymetova, G.; Balla, A.; Toth, Z.E.; Oker-Blom, C.; Roder, J.; Jeromin, A.; Balla, T.
Interaction of neuronal calcium sensor-1 (NCS-1) with phosphatidylinositol 4-kinase b stimulates lipid kinase activity and affects membrane trafficking in COS-7 cells
J. Biol. Chem.
276
40183-40189
2001
Bos taurus, Rattus norvegicus
Wei, Y.J.; Sun, H.Q.; Yamamoto, M.; Wlodarski, P.; Kunii, K.; Martinez, M.; Barylko, B.; Albanesi, J.P.; Yin, H.L.
Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP
J. Biol. Chem.
277
46586-46593
2002
Homo sapiens (Q8TCG2)
Balla, A.; Tuymetova, G.; Barshishat, M.; Geiszt, M.; Balla, T.
Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments
J. Biol. Chem.
277
20041-20050
2002
Homo sapiens (Q8TCG2)
Westergren, T.; Ekblad, L.; Jergil, B.; Sommarin, M.
Phosphatidylinositol 4-kinase associated with spinach plasma membranes. Isolation and characterization of two distinct forms
Plant Physiol.
121
507-516
1999
Spinacia oleracea
Stevenson-Paulik, J.; Love, J.; Boss, W.F.
Differential regulation of two Arabidopsis type III phosphatidylinositol 4-kinase isoforms. A regulatory role for the pleckstrin homology domain
Plant Physiol.
132
1053-1064
2003
Arabidopsis sp.
Guo, J.; Wenk, M.R.; Pellegrini, L.; Onofri, F.; Benfenati, F.; De Camilli, P.
Phosphatidylinositol 4-kinase type IIalpha is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles
Proc. Natl. Acad. Sci. USA
100
3995-4000
2003
Rattus norvegicus
Audhya, A.; Foti, M.; Emr, S.D.
Distinct roles for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamics
Mol. Biol. Cell
11
2673-2689
2000
Saccharomyces cerevisiae
Prajda, N.; Singhal, R.L.; Yeh, Y.A.; Olah, E.; Look, K.Y.; Weber, G.
Linkage of reduction in 1-phosphatidylinositol 4-kinase activity and inositol 1,4,5-trisphosphate concentration in human ovarian carcinoma cells treated with quercetin
Life Sci.
56
1587-1593
1995
Homo sapiens
Verghese, M.; Fernandis, A.Z.; Subrahmanyam, G.
Purification and characterization of a type II phosphatidylinositol 4-kinase from rat spleen and comparison with a PtdIns 4-kinase from lymphocytes
Indian J. Biochem. Biophys.
36
1-9
1999
Rattus norvegicus
Olsen, H.L.; Hoy, M.; Zhang, W.; Bertorello, A.M.; Bokvist, K.; Capito, K.; Efanov, A.M.; Meister, B.; Thams, P.; Yang, S.N.; Rorsman, P.; Berggren, P.O.; Gromada, J.
Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells
Proc. Natl. Acad. Sci. USA
100
5187-5192
2003
Mus musculus
Shelton, S.N.; Barylko, B.; Binns, D.D.; Horazdovsky, B.F.; Albanesi, J.P.; Goodman, J.M.
Saccharomyces cerevisiae contains a type II phosphoinositide 4-kinase
Biochem. J.
371
533-540
2003
Saccharomyces cerevisiae
Waugh, M.G.; Minogue, S.; Blumenkrantz, D.; Anderson, J.S.; Hsuan, J.J.
Identification and characterization of differentially active pools of type IIalpha phosphatidylinositol 4-kinase activity in unstimulated A431 cells
Biochem. J.
376
497-503
2003
Homo sapiens
Srivastava, R.; Ratheesh, A.; Gude, R.K.; Rao, K.V.K.; Panda, D.; Subrahmanyam, G.
Resveratrol inhibits type II phosphatidylinositol 4-kinase: A key component in pathways of phosphoinositide turn over
Biochem. Pharmacol.
70
1048-1055
2005
Homo sapiens (Q8TCG2)
Souza, M.S.; Magnarelli de Potas, G.; Pechen de D'Angelo, A.M.
Organophosphorous and organochlorine pesticides affect human placental phosphoinositides metabolism and PI-4 kinase activity
J. Biochem. Mol. Toxicol.
18
30-36
2004
Homo sapiens
Weixel, K.M.; Blumental-Perry, A.; Watkins, S.C.; Aridor, M.; Weisz, O.A.
Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases
J. Biol. Chem.
280
10501-10508
2005
Canis lupus familiaris
Haynes, L.P.; Thomas, G.M.; Burgoyne, R.D.
Interaction of neuronal calcium sensor-1 and ADP-ribosylation factor 1 allows bidirectional control of phosphatidylinositol 4-kinase beta and trans-Golgi network-plasma membrane traffic
J. Biol. Chem.
280
6047-6054
2005
Rattus norvegicus
Wu, B.; Kitagawa, K.; Zhang, N.Y.; Liu, B.; Inagaki, C.
Pathophysiological concentrations of amyloid beta proteins directly inhibit rat brain and recombinant human type II phosphatidylinositol 4-kinase activity
J. Neurochem.
91
1164-1170
2004
Homo sapiens
Balla, A.; Tuymetova, G.; Tsiomenko, A.; Varnai, P.; Balla, T.
A plasma membrane pool of phosphatidylinositol 4-phosphate is generated by phosphatidylinositol 4-kinase type-III alpha: studies with the PH domains of the oxysterol binding protein and FAPP1
Mol. Biol. Cell
16
1282-1295
2005
Homo sapiens
Salazar, G.; Craige, B.; Wainer, B.H.; Guo, J.; De Camilli, P.; Faundez, V.
Phosphatidylinositol-4-kinase type II alpha is a component of adaptor protein-3-derived vesicles
Mol. Biol. Cell
16
3692-3704
2005
Mus musculus
Naveen, B.; Shankar, B.S.; Subrahmanyam, G.
FcepsilonRI cross-linking activates a type II phosphatidylinositol 4-kinase in RBL 2H3 cells
Mol. Immunol.
42
1541-1549
2005
Rattus norvegicus
Etkovitz, N.; Rubinstein, S.; Daniel, L.; Breitbart, H.
Role of PI3-kinase and PI4-kinase in actin polymerization during bovine sperm capacitation
Biol. Reprod.
77
263-273
2007
Bos taurus
Pizarro-Cerda, J.; Payrastre, B.; Wang, Y.J.; Veiga, E.; Yin, H.L.; Cossart, P.
Type II phosphatidylinositol 4-kinases promote Listeria monocytogenes entry into target cells
Cell. Microbiol.
9
2381-2390
2007
Homo sapiens
Kakuk, A.; Friedlaender, E.; Vereb, G.; Kasa, A.; Balla, A.; Balla, T.; Heilmeyer, L.M.; Gergely, P.; Vereb, G.
Nucleolar localization of phosphatidylinositol 4-kinase PI4K230 in various mammalian cells
Cytometry A
69
1174-1183
2006
Homo sapiens, Rattus norvegicus
Rodgers, M.J.; Albanesi, J.P.; Phillips, M.A.
Phosphatidylinositol 4-kinase III-beta is required for golgi maintenance and cytokinesis in Trypanosoma brucei
Eukaryot. Cell
6
1108-1118
2007
Trypanosoma brucei
Ishihara, Y.; Furuno, T.; Nakanishi, M.
The role of phosphatidylinositol 4-kinase type IIalpha in degranulation of RBL-2H3 cells
Inflamm. Res.
55
465-468
2006
Rattus norvegicus
Szivak, I.; Lamb, N.; Heilmeyer, L.M.
Subcellular localization and structural function of endogenous phosphorylated phosphatidylinositol 4-kinase (PI4K92)
J. Biol. Chem.
281
16740-16749
2006
Homo sapiens
Toth, B.; Balla, A.; Ma, H.; Knight, Z.A.; Shokat, K.M.; Balla, T.
Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi
J. Biol. Chem.
281
36369-36377
2006
Homo sapiens
Waugh, M.G.; Minogue, S.; Chotai, D.; Berditchevski, F.; Hsuan, J.J.
Lipid and peptide control of phosphatidylinositol 4-kinase IIalpha activity on Golgi-endosomal rafts
J. Biol. Chem.
281
3757-3763
2006
Homo sapiens
Davis, A.J.; Im, Y.J.; Dubin, J.S.; Tomer, K.B.; Boss, W.F.
Arabidopsis phosphatidylinositol phosphate kinase 1 binds F-actin and recruits phosphatidylinositol 4-kinase beta1 to the actin cytoskeleton
J. Biol. Chem.
282
14121-14131
2007
Arabidopsis thaliana
Strahl, T.; Huttner, I.G.; Lusin, J.D.; Osawa, M.; King, D.; Thorner, J.; Ames, J.B.
Structural Insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1)
J. Biol. Chem.
282
30949-30959
2007
Saccharomyces cerevisiae
Jeganathan, S.; Lee, J.M.
Binding of elongation factor eEF1A2 to phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and phosphatidylinositol 4-phosphate generation
J. Biol. Chem.
282
372-380
2007
Homo sapiens
Chang, F.S.; Han, G.S.; Carman, G.M.; Blumer, K.J.
A WASp-binding type II phosphatidylinositol 4-kinase required for actin polymerization-driven endosome motility
J. Cell Biol.
171
133-142
2005
Saccharomyces cerevisiae
Strahl, T.; Hama, H.; DeWald, D.B.; Thorner, J.
Yeast phosphatidylinositol 4-kinase, Pik1, has essential roles at the Golgi and in the nucleus
J. Cell Biol.
171
967-979
2005
Saccharomyces cerevisiae
Minogue, S.; Waugh, M.G.; De Matteis, M.A.; Stephens, D.J.; Berditchevski, F.; Hsuan, J.J.
Phosphatidylinositol 4-kinase is required for endosomal trafficking and degradation of the EGF receptor
J. Cell Sci.
119
571-580
2006
Homo sapiens
Xu, Z.; Huang, G.; Kandror, K.V.
Phosphatidylinositol 4-kinase type IIalpha is targeted specifically to cellugyrin-positive glucose transporter 4 vesicles
Mol. Endocrinol.
20
2890-2897
2006
Mus musculus
Wu, B.; Kitagawa, K.; Liu, B.; Zhang, N.Y.; Xiong, Z.M.; Inagaki, C.
Attenuation of amyloid beta (Abeta)-induced inhibition of phosphatidylinositol 4-kinase activity by Abeta fragments, Abeta20-29 and Abeta31-35
Neurosci. Lett.
396
148-152
2006
Rattus norvegicus
Lou, Y.; Ma, H.; Lin, W.H.; Chu, Z.Q.; Mueller-Roeber, B.; Xu, Z.H.; Xue, H.W.
The highly charged region of plant beta-type phosphatidylinositol 4-kinase is involved in membrane targeting and phospholipid binding
Plant Mol. Biol.
60
729-746
2006
Arabidopsis thaliana, Oryza sativa (Q2KT23), Oryza sativa
Krinke, O.; Ruelland, E.; Valentova, O.; Vergnolle, C.; Renou, J.P.; Taconnat, L.; Flemr, M.; Burketova, L.; Zachowski, A.
Phosphatidylinositol 4-kinase activation is an early response to salicylic acid in Arabidopsis suspension cells
Plant Physiol.
144
1347-1359
2007
Arabidopsis thaliana
Balla, A.; Balla, T.
Phosphatidylinositol 4-kinases: old enzymes with emerging functions
Trends Cell Biol.
16
351-361
2006
Saccharomyces cerevisiae
Xiong, Z.M.; Kitagawa, K.; Nishiuchi, Y.; Kimura, T.; Inagaki, C.
Protective effects of Abeta-derived tripeptide, Abeta(32-34), on Abeta(1-42)-induced phosphatidylinositol 4-kinase inhibition and neurotoxicity
Neurosci. Lett.
419
247-252
2007
Homo sapiens
Delang, L.; Paeshuyse, J.; Neyts, J.
The role of phosphatidylinositol 4-kinases and phosphatidylinositol 4-phosphate during viral replication
Biochem. Pharmacol.
84
1400-1408
2012
Homo sapiens
Szentpetery, Z.; Szakacs, G.; Bojjireddy, N.; Tai, A.W.; Balla, T.
Genetic and functional studies of phosphatidyl-inositol 4-kinase type IIIalpha
Biochim. Biophys. Acta
1811
476-483
2011
Homo sapiens
Waugh, M.G.
Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer
Cancer Lett.
325
125-131
2012
Homo sapiens
Burgess, J.; Del Bel, L.M.; Ma, C.I.; Barylko, B.; Polevoy, G.; Rollins, J.; Albanesi, J.P.; Kraemer, H.; Brill, J.A.
Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila
Development
139
3040-3050
2012
Drosophila melanogaster
Moessinger, J.; Wieffer, M.; Krause, E.; Freund, C.; Gerth, F.; Krauss, M.; Haucke, V.
Phosphatidylinositol 4-kinase IIalpha function at endosomes is regulated by the ubiquitin ligase Itch
EMBO Rep.
13
1087-1094
2012
Homo sapiens
Jung, G.; Barylko, B.; Lu, D.; Shu, H.; Yin, H.; Albanesi, J.P.
Stabilization of phosphatidylinositol 4-kinase type IIbeta by interaction with Hsp90
J. Biol. Chem.
286
12775-12784
2011
Homo sapiens, Rattus norvegicus
Cappell, S.D.; Dohlman, H.G.
Selective regulation of MAP kinase signaling by an endomembrane phosphatidylinositol 4-kinase
J. Biol. Chem.
286
14852-14860
2011
Saccharomyces cerevisiae
Wang, K.; Yang, Z.; Liu, X.; Mao, K.; Nair, U.; Klionsky, D.J.
Phosphatidylinositol 4-kinases are required for autophagic membrane trafficking
J. Biol. Chem.
287
37964-37972
2012
Saccharomyces cerevisiae, Saccharomyces cerevisiae TKYM107
Yang, N.; Ma, P.; Lang, J.; Zhang, Y.; Deng, J.; Ju, X.; Zhang, G.; Jiang, C.
Phosphatidylinositol 4-kinase IIIbeta is required for severe acute respiratory syndrome coronavirus spike-mediated cell entry
J. Biol. Chem.
287
8457-8467
2012
Chlorocebus sabaeus, Homo sapiens
Dumaresq-Doiron, K.; Savard, M.F.; Akam, S.; Costantino, S.; Lefrancois, S.
The phosphatidylinositol 4-kinase PI4KIIIalpha is required for the recruitment of GBF1 to Golgi membranes
J. Cell Sci.
123
2273-2280
2010
Saccharomyces cerevisiae
Berger, K.L.; Kelly, S.M.; Jordan, T.X.; Tartell, M.A.; Randall, G.
Hepatitis C virus stimulates the phosphatidylinositol 4-kinase III alpha-dependent phosphatidylinositol 4-phosphate production that is essential for its replication
J. Virol.
85
8870-8883
2011
Homo sapiens
Banerji, S.; Ngo, M.; Lane, C.F.; Robinson, C.A.; Minogue, S.; Ridgway, N.D.
Oxysterol binding protein-dependent activation of sphingomyelin synthesis in the Golgi apparatus requires phosphatidylinositol 4-kinase IIalpha
Mol. Biol. Cell
21
4141-4150
2010
Cricetulus griseus, Homo sapiens
Jovic, M.; Kean, M.J.; Szentpetery, Z.; Polevoy, G.; Gingras, A.C.; Brill, J.A.; Balla, T.
Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, beta-glucocerebrosidase
Mol. Biol. Cell
23
1533-1545
2012
Homo sapiens
Delage, E.; Ruelland, E.; Guillas, I.; Zachowski, A.; Puyaubert, J.
Arabidopsis type-III phosphatidylinositol 4-kinases beta1 and beta2 are upstream of the phospholipase C pathway triggered by cold exposure
Plant Cell Physiol.
53
565-576
2012
Arabidopsis thaliana
Tai, A.W.; Salloum, S.
The role of the phosphatidylinositol 4-kinase PI4KA in hepatitis C virus-induced host membrane rearrangement
PLoS ONE
6
e26300
2011
Homo sapiens
Bianco, A.; Reghellin, V.; Donnici, L.; Fenu, S.; Alvarez, R.; Baruffa, C.; Peri, F.; Pagani, M.; Abrignani, S.; Neddermann, P.; De Francesco, R.
Metabolism of phosphatidylinositol 4-kinase IIIalpha-dependent PI4P is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity
PLoS Pathog.
8
e1002576
2012
Homo sapiens
Altan-Bonnet, N.; Balla, T.
Phosphatidylinositol 4-kinases: hostages harnessed to build panviral replication platforms
Trends Biochem. Sci.
37
293-302
2012
Saccharomyces cerevisiae, Homo sapiens
Graham, T.R.; Burd, C.G.
Coordination of Golgi functions by phosphatidylinositol 4-kinases
Trends Cell Biol.
21
113-121
2011
Saccharomyces cerevisiae, Homo sapiens
Klima, M.; Baumlova, A.; Chalupska, D.; Hrebabecky, H.; Dejmek, M.; Nencka, R.; Boura, E.
The high-resolution crystal structure of phosphatidylinositol 4-kinase IIbeta and the crystal structure of phosphatidylinositol 4-kinase IIalpha containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design
Acta Crystallogr. Sect. D
71
1555-1563
2015
Homo sapiens (Q8TCG2), Homo sapiens (Q9BTU6)
Sinha, R.K.; Bojjireddy, N.; Kulkarni, D.; Ratheesh, A.; Chiplunkar, S.V.; Gude, R.; Subrahmanyam, G.
Type II phosphatidylinositol 4-kinase beta is an integral signaling component of early T cell activation mechanisms
Biochimie
95
1560-1566
2013
Homo sapiens
Baumlova, A.; Chalupska, D.; Rozycki, B.; Jovic, M.; Wisniewski, E.; Klima, M.; Dubankova, A.; Kloer, D.P.; Nencka, R.; Balla, T.; Boura, E.
The crystal structure of the phosphatidylinositol 4-kinase IIalpha
EMBO Rep.
15
1085-1092
2014
Homo sapiens (Q9BTU6)
Rutaganira, F.U.; Fowler, M.L.; McPhail, J.A.; Gelman, M.A.; Nguyen, K.; Xiong, A.; Dornan, G.L.; Tavshanjian, B.; Glenn, J.S.; Shokat, K.M.; Burke, J.E.
Design and structural characterization of potent and selective inhibitors of phosphatidylinositol 4 kinase IIIbeta
J. Med. Chem.
59
1830-1839
2016
Homo sapiens
Harak, C.; Radujkovic, D.; Taveneau, C.; Reiss, S.; Klein, R.; Bressanelli, S.; Lohmann, V.
Mapping of functional domains of the lipid kinase phosphatidylinositol 4-kinase type III alpha involved in enzymatic activity and hepatitis C virus replication
J. Virol.
88
9909-9926
2014
Homo sapiens
Gimenez, A.M.; Gesumaria, M.C.; Schoijet, A.C.; Alonso, G.D.; Flawia, M.M.; Racagni, G.E.; Machado, E.E.
Phosphatidylinositol kinase activities in Trypanosoma cruzi epimastigotes
Mol. Biochem. Parasitol.
203
14-24
2015
Trypanosoma cruzi
Ryder, P.V.; Vistein, R.; Gokhale, A.; Seaman, M.N.; Puthenveedu, M.A.; Faundez, V.
The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIalpha
Mol. Biol. Cell
24
2269-2284
2013
Homo sapiens
Akhter, S.; Uddin, M.N.; Jeong, I.S.; Kim, D.W.; Liu, X.M.; Bahk, J.D.
Role of Arabidopsis AtPI4Kgamma3, a type II phosphoinositide 4-kinase, in abiotic stress responses and floral transition
Plant Biotechnol. J.
14
215-230
2016
Arabidopsis thaliana
Arita, M.; Dobrikov, G.; Puerstinger, G.; Galabov, A.S.
Allosteric Regulation of Phosphatidylinositol 4-Kinase III Beta by an Antipicornavirus Compound MDL-860
ACS Infect. Dis.
3
585-594
2017
Homo sapiens
Fienberg, S.; Eyermann, C.J.; Arendse, L.; Basarab, G.S.; McPhail, J.; Burke, J.E.; Chibale, K.
Structural Basis for Inhibitor Potency and Selectivity of Plasmodium falciparum Phosphatidylinositol 4-kinase Inhibitors
ACS Infect. Dis.
6
3048-3063
2020
Plasmodium falciparum
Kalachova, T.; Janda, M.; Sasek, V.; Ortmannova, J.; Novakova, P.; Dobrev, I.P.; Kravets, V.; Guivarch, A.; Moura, D.; Burketova, L.; Valentova, O.; Ruelland, E.
Identification of salicylic acid-independent responses in an Arabidopsis phosphatidylinositol 4-kinase beta double mutant
Ann. Bot.
125
775-784
2020
Arabidopsis thaliana
Sternberg, A.R.; Roepe, P.D.
Heterologous expression, purification, and functional analysis of the Plasmodium falciparum phosphatidylinositol 4-kinase IIIbeta
Biochemistry
59
2494-2506
2020
Plasmodium falciparum (Q8I406), Plasmodium falciparum
Sala, M.; Koegler, M.; Plackova, P.; Mejdrova, I.; Hrebabecky, H.; Prochazkova, E.; Strunin, D.; Lee, G.; Birkus, G.; Weber, J.; Mertlikova-Kaiserova, H.; Nencka, R.
Purine analogs as phosphatidylinositol 4-kinase IIIbeta inhibitors
Bioorg. Med. Chem. Lett.
26
2706-2712
2016
Homo sapiens
Takahashi, S.; Monda, K.; Higaki, T.; Hashimoto-Sugimoto, M.; Negi, J.; Hasezawa, S.; Iba, K.
Differential effects of phosphatidylinositol 4-kinase (PI4K) and 3-kinase (PI3K) Inhibitors on stomatal responses to environmental signals
Front. Plant Sci.
8
677
2017
Arabidopsis thaliana
Chen, L.; Zhang, L.; Mei, X.; Wang, C.; Guo, Z.; Li, L.; Li, B.; Liang, Y.; Zou, S.; Dong, H.
The type II phosphoinositide 4-kinase FgLsb6 is important for the development and virulence of Fusarium graminearum
Fungal Genet. Biol.
144
103443
2020
Fusarium graminearum, Fusarium graminearum PH-1
Mohamed, M.; Gardeitchik, T.; Balasubramaniam, S.; Guerrero-Castillo, S.; Dalloyaux, D.; van Kraaij, S.; Venselaar, H.; Hoischen, A.; Urban, Z.; Brandt, U.; Al-Shawi, R.; Simons, J.P.; Frison, M.; Ngu, L.H.; Callewaert, B.; Spelbrink, H.; Kallemeijn, W.W.; Aerts, J.M.F.G.; Waugh, M.G.; Morava, E.; We, W.e.v.
Novel defect in phosphatidylinositol 4-kinase type 2-alpha (PI4K2A) at the membrane-enzyme interface is associated with metabolic cutis laxa
J. Inherit. Metab. Dis.
43
1382-1391
2020
Homo sapiens
Sengupta, N.; Jovic, M.; Barnaeva, E.; Kim, D.W.; Hu, X.; Southall, N.; Dejmek, M.; Mejdrova, I.; Nencka, R.; Baumlova, A.; Chalupska, D.; Boura, E.; Ferrer, M.; Marugan, J.; Balla, T.
A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha
J. Lipid Res.
60
683-693
2019
Homo sapiens
Mejdrova, I.; Chalupska, D.; Plackova, P.; Mueller, C.; Sala, M.; Klima, M.; Baumlova, A.; Hrebabecky, H.; Prochazkova, E.; Dejmek, M.; Strunin, D.; Weber, J.; Lee, G.; Matousova, M.; Mertlikova-Kaiserova, H.; Ziebuhr, J.; Birkus, G.; Boura, E.; Nencka, R.
Rational design of novel highly potent and selective phosphatidylinositol 4-kinase IIIbeta (PI4KB) inhibitors as broad-spectrum antiviral agents and tools for chemical biology
J. Med. Chem.
60
100-118
2017
Homo sapiens, Homo sapiens (Q9UBF8)
Kandepedu, N.; Gonzalez Cabrera, D.; Eedubilli, S.; Taylor, D.; Brunschwig, C.; Gibhard, L.; Njoroge, M.; Lawrence, N.; Paquet, T.; Eyermann, C.J.; Spangenberg, T.; Basarab, G.S.; Street, L.J.; Chibale, K.
Identification, characterization, and optimization of 2,8-disubstituted-1,5-naphthyridines as novel Plasmodium falciparum phosphatidylinositol-4-kinase inhibitors with in vivo efficacy in a humanized mouse model of malaria
J. Med. Chem.
61
5692-5703
2018
Plasmodium falciparum, Plasmodium vivax
Chalupska, D.; Eisenreichova, A.; Rozycki, B.; Rezabkova, L.; Humpolickova, J.; Klima, M.; Boura, E.
Structural analysis of phosphatidylinositol 4-kinase IIIbeta (PI4KB) - 14-3-3 protein complex reveals internal flexibility and explains 14-3-3 mediated protection from degradation in vitro
J. Struct. Biol.
200
36-44
2017
Homo sapiens (Q9UBF8)
Alli-Balogun, G.O.; Gewinner, C.A.; Jacobs, R.; Kriston-Vizi, J.; Waugh, M.G.; Minogue, S.
Phosphatidylinositol 4-kinase IIbeta negatively regulates invadopodia formation and suppresses an invasive cellular phenotype
Mol. Biol. Cell
27
4033-4042
2016
Homo sapiens
Mansi, H.; Kushwaha, N.K.; Singh, A.K.; Karim, M.J.; Chakraborty, S.
Nicotiana benthamiana phosphatidylinositol 4-kinase type II regulates chilli leaf curl virus pathogenesis
Mol. Plant Pathol.
20
1408-1424
2019
Nicotiana benthamiana
Tang, Y.; Zhao, C.Y.; Tan, S.T.; Xue, H.W.
Arabidopsis type II phosphatidylinositol 4-kinase PI4Kgamma5 regulates auxin biosynthesis and leaf margin development through interacting with membrane-bound transcription factor ANAC078
PLoS Genet.
12
e1006252
2016
Arabidopsis thaliana
Daboussi, L.; Costaguta, G.; Ghukasyan, R.; Payne, G.S.
Conserved role for Gga proteins in phosphatidylinositol 4-kinase localization to the trans-Golgi network
Proc. Natl. Acad. Sci. USA
114
3433-3438
2017
Saccharomyces cerevisiae, Homo sapiens
Lopez-Haber, C.; Levin-Konigsberg, R.; Zhu, Y.; Bi-Karchin, J.; Balla, T.; Grinstein, S.; Marks, M.S.; Mantegazza, A.R.
Phosphatidylinositol-4-kinase IIalpha licenses phagosomes for TLR4 signaling and MHC-II presentation in dendritic cells
Proc. Natl. Acad. Sci. USA
117
28251-28262
2020
Mus musculus
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