Information on EC 2.7.1.65 - scyllo-inosamine 4-kinase

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The expected taxonomic range for this enzyme is: Streptomyces

EC NUMBER
COMMENTARY hide
2.7.1.65
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RECOMMENDED NAME
GeneOntology No.
scyllo-inosamine 4-kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 1-amino-1-deoxy-scyllo-inositol = ADP + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
-
-
streptomycin biosynthesis
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-
Streptomycin biosynthesis
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-
SYSTEMATIC NAME
IUBMB Comments
ATP:1-amino-1-deoxy-scyllo-inositol 4-phosphotransferase
Also acts on streptamine, 2-deoxystreptamine and 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol.
CAS REGISTRY NUMBER
COMMENTARY hide
37278-08-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
ATCC 11062
-
-
Manually annotated by BRENDA team
ATCC 12475
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-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2'-deoxy-ATP + scyllo-inosamine
2'-deoxy-ADP + scyllo-inosamine phosphate
show the reaction diagram
-
-
-
?
ATP + 1-amino-1-deoxy-scyllo-inositol
ADP + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
show the reaction diagram
ATP + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol 6-phosphate + ADP
show the reaction diagram
-
-
-
?
ATP + 2-deoxystreptamine
?
show the reaction diagram
-
-
-
-
?
ATP + scyllo-inosamine
ADP + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
show the reaction diagram
-
reaction involved in biosynthesis of streptidine from myo-inositol
-
-
-
ATP + streptamine
?
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + scyllo-inosamine
ADP + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
show the reaction diagram
-
reaction involved in biosynthesis of streptidine from myo-inositol
-
-
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mn2+
-
or Mg2+ required
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Formamidine disulfite
-
-
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p-chloromercuribenzoate
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
mercaptan required during purification
-
purified enzyme preparations are stabilized by addition of serum albumin and mercaptans
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ammonium sulfate, Sephadex G-100 or DEAE-cellulose
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