Information on EC 2.7.1.61 - acyl-phosphate-hexose phosphotransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.7.1.61
-
RECOMMENDED NAME
GeneOntology No.
acyl-phosphate-hexose phosphotransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acyl phosphate + D-hexose = a carboxylate + D-hexose phosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
acyl-phosphate:D-hexose phosphotransferase
Phosphorylates D-glucose and D-mannose on O-6, and D-fructose on O-1 or O-6.
CAS REGISTRY NUMBER
COMMENTARY hide
37278-06-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acyl phosphate + D-hexose
an acid + D-hexose phosphate
show the reaction diagram
-
-
-
-
-
D-fructose + acetyl phosphate
D-fructose 1-phosphate + D-fructose 6-phosphate + acetate
show the reaction diagram
D-glucose + acetyl phosphate
D-glucose 6-phosphate + acetate
show the reaction diagram
D-glucose + carbamoyl phosphate
D-glucose 6-phosphate + carbamate
show the reaction diagram
D-glucose + D-fructose 1-phosphate
D-glucose 6-phosphate + D-fructose
show the reaction diagram
-
15% of the activity with acetyl phosphate or carbamoyl phosphate
-
-
?
D-glucose + D-fructose 6-phosphate
D-glucose 6-phosphate + D-fructose
show the reaction diagram
-
25% of the activity with acetyl phosphate or carbamoyl phosphate
-
-
?
D-glucose + D-glucose 1-phosphate
D-glucose 6-phosphate + D-glucose
show the reaction diagram
-
5% of the activity with acetyl phosphate or carbamoyl phosphate
-
-
?
D-glucose + D-mannose 6-phosphate
D-glucose 6-phosphate + D-mannose
show the reaction diagram
D-glucose + D-ribose 5-phosphate
D-glucose 6-phosphate + D-ribose
show the reaction diagram
-
18% of the activity with acetyl phosphate or carbamoyl phosphate
-
-
?
D-glucose + D-sorbitol 6-phosphate
D-glucose 6-phosphate + D-sorbitol
show the reaction diagram
-
2.5% of the activity with acetyl phosphate or carbamoyl phosphate
-
-
?
D-mannitol + acetyl phosphate
?
show the reaction diagram
-
-
-
-
?
D-mannose + acetyl phosphate
D-mannose 6-phosphate + acetate
show the reaction diagram
N-acetylglucosamine + acetyl phosphate
?
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acyl phosphate + D-hexose
an acid + D-hexose phosphate
show the reaction diagram
-
-
-
-
-
D-glucose + acetyl phosphate
D-glucose 6-phosphate + acetate
show the reaction diagram
D-glucose + D-mannose 6-phosphate
D-glucose 6-phosphate + D-mannose
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
no stimulation by addition of various cations
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
D-mannose
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inhibits phosphorylation of D-glucose, competitive to acetyl phosphate or D-mannose 6-phosphate
N-acetylglucosamine
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-
additional information
-
not inhibitory: EDTA
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.4
acetyl phosphate
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carbamoyl phosphate, D-mannose 6-phosphate, pH 7.5, 25°C
0.16
D-glucose
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pH 7.5, 25°C
12
D-mannose
-
pH 7.5, 25°C
2
D-ribose 5-phosphate
-
pH 7.5, 25°C
67
mannitol
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pH 7.5, 25°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1.3
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pH 7.5, 25°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5 - 9
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pH 7.5: 50% of maximum activity, pH 9: maximum activity
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
150000
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gel filtration
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
stable to repeated freezing and thawing
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, stable
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE