Information on EC 2.7.1.55 - allose kinase

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The expected taxonomic range for this enzyme is: Klebsiella aerogenes

EC NUMBER
COMMENTARY hide
2.7.1.55
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RECOMMENDED NAME
GeneOntology No.
allose kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + D-allose = ADP + D-allose 6-phosphate
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
D-allose degradation
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Fructose and mannose metabolism
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Microbial metabolism in diverse environments
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SYSTEMATIC NAME
IUBMB Comments
ATP:D-allose 6-phosphotransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9031-78-1
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + allitol
ADP + allitol 6-phosphate
show the reaction diagram
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2.8% of activity with D-allose
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-
?
ATP + D-allose
ADP + D-allose 6-phosphate
show the reaction diagram
ATP + D-galactose
ADP + D-galactose 6-phosphate
show the reaction diagram
-
3.5% of activity with D-allose
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-
?
ATP + D-glucose
ADP + D-glucose 6-phosphate
show the reaction diagram
-
20% of activity with D-allose
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-
?
ATP + D-ribose
ADP + D-ribose 5-phosphate
show the reaction diagram
-
6.3% of activity with D-allose
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-
?
additional information
?
-
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CTP: 50% of activity with ATP, ITP: 43% of activity with ATP
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + D-allose
ADP + D-allose 6-phosphate
show the reaction diagram
-
first step of Embden-Meyerhof-Parnas pathway
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-
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
37% as effective as Mg2+
Mg2+
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requirement
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
EDTA
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10 mM: 50% inhibition
p-chloromercuribenzoate
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strong, addition of GSH reduces inhibition to 13%
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.98
D-Allose
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25°C, pH 6.5
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1.93
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25°C, pH 6.5
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 7.5
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40% of maximal activity at pH 5, 50% of maximal activity at pH 7.5
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
PDB
SCOP
CATH
ORGANISM
UNIPROT
Escherichia coli (strain K12)
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 8
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0°C, 10 min, 10% remaining activity at pH 5, 80% remaining activity at pH 8
636977
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
GSH stabilizes
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
0°C, 0.01 M glycerol, 0.002 M KH2PO4, 0.001 M EDTA, 16 h, 70-80% remaining activity
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Show AA Sequence (213 entries)
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