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Reference on EC 2.7.1.40 - pyruvate kinase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pawluk, A.; Scopes, R.K.; Griffiths-Smith, K.
Isolation and properties of the glycolytic enzymes from Zymomonas mobilis. The five enzymes from glyceraldehyde-3-phosphate dehydrogenase through to pyruvate kinase
Biochem. J.
238
275-281
1986
Zymomonas mobilis
Manually annotated by BRENDA team
De Graaff, L.; Van den Broeck, H.; Visser, J.
Isolation and characterization of the Aspergillus niger pyruvate kinase gene
Curr. Genet.
22
21-27
1992
Aspergillus nidulans, Aspergillus niger
Manually annotated by BRENDA team
Isani, G.; Cattani, O.; Carpene, E.; Cortesi, P.
Kinetic properties of liver and muscle pyruvate kinase of a marine teleost, sea bass (Dicentrarchus labrax L.).
Comp. Biochem. Physiol. B Biochem. Mol. Biol.
107
617-624
1994
Dicentrarchus labrax
-
Manually annotated by BRENDA team
Zamora, J.M.; Rosa, R.; Rosa, C.D.; Bianconcini M.S.C.; Bacila, M.
Purification and properties of pyruvate kinase from the striated muscle f the ice-fish Chaenocephalus aceratus Loenberg
Int. J. Biochem.
24
1833-1840
1992
Chaenocephalus aceratus
-
Manually annotated by BRENDA team
Wu, H.B.; Turpin, D.H.
Purification and characteization of pyruvate kinase from the green alga Chlamydomonas reinhardtii
J. Phycol.
28
472-481
1992
Chlamydomonas reinhardtii
-
Manually annotated by BRENDA team
Callens, M.; Opperdoes, F.R.
Some kinetic properties of pyruvate kinase from Trypanosoma brucei
Mol. Biochem. Parasitol.
50
235-243
1992
Trypanosoma brucei
Manually annotated by BRENDA team
Kiffmeyer, W.R.; Farrar, W.W.
Purification and properties of pig heart pyruvate kinase
J. Protein Chem.
10
585-591
1991
Sus scrofa
Manually annotated by BRENDA team
Singh, S.P.; Rogers, P.J.; Singh, S.P.
Purification and kinetic properties of pyruvate kinase from Brochothrix thermosphacta
Biochem. Int.
25
35-45
1991
Brochothrix thermosphacta
Manually annotated by BRENDA team
Schmidt-Base, K.; Buchbinder, J.L.; Reed, G.H.; Rayment, I.
Crystallization and preliminary analysis of enzyme-substrate complexes of pyruvate kinase from rabbit muscle
Proteins Struct. Funct. Genet.
11
153-157
1991
Oryctolagus cuniculus
Manually annotated by BRENDA team
Agboola, F.K.; Afolayan, A.
Purification and some properties of pyruvate kinase from the skeletal muscle of African land turtoise Kinixys erosa (Linn)
Comp. Biochem. Physiol. B
99
513-521
1991
Kinixys erosa
-
Manually annotated by BRENDA team
Marshall, J.; Wheldrake, J.F.
Purification and properties of pyruvate kinase from Dictyostelium discoideum
Biochem. Int.
21
615-622
1990
Dictyostelium discoideum
Manually annotated by BRENDA team
Gupta, V.K.; Singh, R.
Properties of pyruvate kinase from immature pod wall of chickpea
Plant Physiol. Biochem.
27
703-711
1989
Cicer arietinum
-
Manually annotated by BRENDA team
Terlecki, G.
Purification and properties of pyruvate kinase type M1 from bovine brain
Int. J. Biochem.
21
1053-1060
1989
Bos taurus
Manually annotated by BRENDA team
Wakita, M.; Hoshino, S.
Enzymatic properties of pyruvate kinase from the rumen ciliates genus Entodinium
Int. J. Biochem.
21
777-781
1989
Entodinium sp.
Manually annotated by BRENDA team
Calomenopoulou, M.; Kaloyianni, M.; Beis, I.D.
Purification and regulatory properties of pigeon erythrocyte pyruvate kinase
Comp. Biochem. Physiol. B
93
697-706
1989
Pigeon
Manually annotated by BRENDA team
Etges, R.; Mukkada, A.J.
Purification and characterization of a metabolite-regulated pyruvate kinase from Leishmania major promastigotes
Mol. Biochem. Parasitol.
27
281-289
1988
Leishmania major
Manually annotated by BRENDA team
Carvajal, N.; Gonzalez, R.; Moran, A.
Properties of pyruvate kinase from the heart of Concholepas concholepas
Comp. Biochem. Physiol. B
85
577-580
1986
Concholepas concholepas
-
Manually annotated by BRENDA team
Kobayashi, H.; Ozawa, K.; Yamada, S.
Physical and catalytic properties of pyruvate kinase from pig dental pulp
Arch. Oral Biol.
31
559-563
1986
Sus scrofa
Manually annotated by BRENDA team
Sand, O.
Kinetic properties of liver pyruvate kinase from the flounder (Platichthys flesus L.)
Comp. Biochem. Physiol. B
84
91-96
1986
Platichthys flesus
Manually annotated by BRENDA team
Michaelidis, B.; Lazou, A.; Beis, I.
Purification, catalytic and regulatory properties of pyruvate kinase from the foot of Patella caerulea (L.)
Comp. Biochem. Physiol. B
82
405-412
1985
Patella caerulea
-
Manually annotated by BRENDA team
Chrispeels, M.J.; Gaede, G.
Purification and characterization of pyruvate kinase from the foot muscle of the cockle, Cardium tuberculatum
Comp. Biochem. Physiol. B
82
162-172
1985
Acanthocardia tuberculata
-
Manually annotated by BRENDA team
Cortesi, P.; Fabbri, D.; Isani, G.; Cattani, O.; Carpene, E.
Characterization of pyruvate kinase isolated from the adductor muscle of the mollusk Scapharca inaequivalvis
Comp. Biochem. Physiol. B
81
123-129
1985
Chamelea gallina, Anadara inaequivalvis
-
Manually annotated by BRENDA team
Storey, K.
Kinetic and regulatory properties of pyruvate kinase isozymes from flight muscle and fat body of the cockroach, Periplaneta americana
J. Comp. Physiol. B
155
339-345
1985
Periplaneta americana
-
Manually annotated by BRENDA team
Lesicki, A.; Jungst, M.
Properties of pyruvate kinase from fat body of Tenebrio molitor L. larvae
Bull. Soc. Amis Sci. Lett,Poznan,Ser. D
24
31-38
1984
Tenebrio molitor
-
Manually annotated by BRENDA team
Busto, F.; Del Valle, P.; De Arriaga, D.; Soler, J.
Some kinetic properties of pyruvate kinase from Phycomyces blakesleeanus
Int. J. Biochem.
17
253-257
1985
Phycomyces blakesleeanus
-
Manually annotated by BRENDA team
Roberts, B.; Anderson, P.J.
The purification and kinetic characterization of eel white muscle pyruvate kinase
Comp. Biochem. Physiol. B
80
51-56
1985
Anguilla rostrata
Manually annotated by BRENDA team
Sand, O.
Purification and properties of pyruvate kinase from liver of the flounder (Platichthys flesus L.)
Comp. Biochem. Physiol. B
79
473-479
1984
Platichthys flesus
Manually annotated by BRENDA team
Kaloyianni-Dimitriades, M.G.; Beis, I.D.
Purification, catalytic and regulatory properties of Rana ridibunda erythrocyte pyruvate kinase
Comp. Biochem. Physiol. B
79
245-250
1984
Pelophylax ridibundus
Manually annotated by BRENDA team
Sanchez, J.L.; Abad, M.; Garcia Martin, L.O.; Galarza, A.
Purification and properties of pyruvate kinase from the hepatopancreas of Mytilus galloprovincialis L.
Comp. Biochem. Physiol. B
78
873-879
1984
Mytilus galloprovincialis
-
Manually annotated by BRENDA team
Carpene, E.; Cortesi, P.; Isani, G.; Cattani, O.
Characteristics of pyruvate kinase isolated from the adductor muscle of the Adriatic mollusk Venus gallina
Comp. Biochem. Physiol. B
77
693-698
1984
Chamelea gallina
-
Manually annotated by BRENDA team
Fields, J.H.A.
Some catalytic and regulatory properties of pyruvate kinase from the spadix and retractor muscles of Nautilus pompilius
Pac. Sci.
36
315-324
1982
Nautilus pompilius
-
Manually annotated by BRENDA team
Leon, O.; Moran, A.; Gonzalez, R.
Purification and characterization of pyruvate kinase from muscle of the sea mollusk Concholepas concholepas
Comp. Biochem. Physiol. B
72
65-69
1982
Concholepas concholepas
-
Manually annotated by BRENDA team
Flynn, I.W.; Bowman, I.B.R.
Some kinetic properties of pyruvate kinase from Trypanosoma brucei: influence of pH and fructose-1,6-diphosphate
Mol. Biochem. Parasitol.
4
95-106
1981
Trypanosoma brucei
Manually annotated by BRENDA team
Wu, S.W.N.; Wong, S.C.; Yeung, D.
Purification and properties of dog muscle pyruvate kinase
Int. J. Biochem.
13
147-152
1981
Canis lupus familiaris
Manually annotated by BRENDA team
Guderley, H.; Hochachka, P.W.
Catalytic and regulatory properties of muscle pyruvate kinase from Cancer magister
J. Exp. Zool.
212
461-469
1980
Metacarcinus magister
Manually annotated by BRENDA team
Guderley, H.; Cardenas, J.M.
A study of the catalytic properties of pyruvate kinase isozymes from salmon and an examination of their functional relationships
J. Exp. Zool.
212
269-277
1980
Oncorhynchus kisutch
-
Manually annotated by BRENDA team
Guderley, H.; Cardenas, J.M.
Pyruvate kinases of salmon: purification and comparison with the isozymes from birds and mammals
J. Exp. Zool.
211
185-198
1980
Oncorhynchus kisutch
Manually annotated by BRENDA team
Tuominen, F.W.; Bernlohr, R.W.
Pyruvate kinase of Bacillus licheniformis
Methods Enzymol.
42C
157-166
1975
Bacillus licheniformis, Bacillus licheniformis A-5
-
Manually annotated by BRENDA team
Flanders, L.E.; Schloen, L.H.; Sallach, H.J.
Isozymes of pyruvate kinase from the grasfrog
Methods Enzymol.
42C
166-175
1975
Lithobates pipiens
-
Manually annotated by BRENDA team
Aust, A.; Yun, S.L.; Suelter, C.H.
Pyruvate kinase from yeast (Saccharomyces cerevisiae)
Methods Enzymol.
42C
176-182
1975
Saccharomyces cerevisiae, Saccharomyces pastorianus
-
Manually annotated by BRENDA team
Staal, G.E.J.; Koster, J.F.; Veeger, C.
Human erythrocyte pyruvate kinase
Methods Enzymol.
42C
182-186
1975
Homo sapiens
-
Manually annotated by BRENDA team
Kahn, A.; Marie, J.
Pyruvate kinases from human erythrocytes and liver
Methods Enzymol.
90
131-140
1982
Homo sapiens
-
Manually annotated by BRENDA team
Cardenas, J.M.
Pyruvate kinase from bovine muscle and liver
Methods Enzymol.
90
140-149
1982
Bos taurus
-
Manually annotated by BRENDA team
Imamura, K.; Tanaka, T.
Pyruvate kinase isozymes from rat
Methods Enzymol.
90
150-165
1982
Rattus norvegicus
-
Manually annotated by BRENDA team
Crow, V.L.; Pritchard, G.G.
Pyruvate kinase from Streptococcus lactis
Methods Enzymol.
90
165-170
1982
Lactococcus lactis, Lactococcus lactis C10
-
Manually annotated by BRENDA team
Malcovati,M.; Valentini, G.
AMP- and fructose 1,6-bisphosphate-activated pyruvate kinases from Escherichia coli
Methods Enzymol.
90
170-179
1982
Escherichia coli
-
Manually annotated by BRENDA team
Muirhead, H.; Clayden, D.A.; Cuffe, S.P.; Davies, C.
Crystallographic studies on the structure and catalytic activity of pyruvate kinase from skeletal muscle
Biochem. Soc. Trans.
15
996-999
1987
Felis catus
Manually annotated by BRENDA team
Stammers, d.H.; Levine, M.; Stuart, D.I.; Muirhead, H.
Structure of cat muscle pyruvate kinase at 0.26 nm resolution
Biochem. Soc. Trans.
5
654-657
1977
Felis catus
Manually annotated by BRENDA team
Ibsen, K.H.; Chiu, R.H.C.; Park, H.R.; Sanders, D.A.; Roy, S.; Garratt, K.N.; Mueller, M.K.
Purification and properties of mouse pyruvate kinases K and M and of a modified K subunit
Biochemistry
20
1497-1506
1981
Mus musculus
Manually annotated by BRENDA team
Guy, E.C.; Giles, I.G.
Studies on the inhibition of type-M pyruvate kinase by the triazine dye ProcionBlue MX-R
Biochem. Soc. Trans.
14
152
1986
Oryctolagus cuniculus
-
Manually annotated by BRENDA team
Schering, B.; Eigenbrodt, E.; Linder, D.; Schoner, W.
Purification and properties of pyruvate kinase type M2 from rat lung
Biochim. Biophys. Acta
717
337-347
1982
Rattus norvegicus
Manually annotated by BRENDA team
Nagao, Y.; Miyazaki, K.; Matuo, Y.; Yamashita, J.; Horio, T.
Difference in physical and chemical properties between muscle-type and spleen-type isoenzymes of pyruvate kinase in rat
Biochem. Biophys. Res. Commun.
104
713-719
1982
Rattus norvegicus
Manually annotated by BRENDA team
Srivastava, L.K.; Baquer, N.Z.
Purification and properties of rat brain pyruvate kinase
Arch. Biochem. Biophys.
236
703-713
1985
Rattus norvegicus
Manually annotated by BRENDA team
Plaxton, W.C.; Storey, K.B.
Purification and properties of aerobic and anoxic forms of pyruvate kinase from red muscle tissue of the channelled whelk, Busycotypus canaliculatum
Eur. J. Biochem.
143
257-265
1984
Busycotypus canaliculatum
Manually annotated by BRENDA team
Plaxton, W.C.; Storey, K.B.
Purification and properties of aerobic and anoxic forms of pyruvate kinase from the hepatopancreas of the channelled whelk, Busycotypus canaliculatum
Arch. Biochem. Biophys.
243
195-205
1985
Busycotypus canaliculatum
Manually annotated by BRENDA team
Ireland, R.J.; De Luca, V.; Dennis, D.T.
Characterization and kinetics of isoenzymes of pyruvate kinase from developing castor bean endosperm
Plant Physiol.
65
1188-1193
1980
Ricinus communis
Manually annotated by BRENDA team
Plaxton, W.C.
Purification of pyruvate kinase from germinating castor bean endosperm
Plant Physiol.
86
1064-1069
1988
Ricinus communis
Manually annotated by BRENDA team
Plaxton, W.C.; Dennis, D.T.; Knowles, V.L.
Purification of leucoplast pyruvate kinase from developing castor bean endosperm
Plant Physiol.
94
1528-1534
1990
Ricinus communis
Manually annotated by BRENDA team
Baysdorfer, C.; Bassham, J.A.
Spinach pyruvate kinase isoforms. Partial purification and regulatory properties
Plant Physiol.
74
374-379
1984
Saccharomyces cerevisiae, Spinacia oleracea
Manually annotated by BRENDA team
Ruyters, G.; Grotjohann, N.; Kowallik, W.
Oligomeric forms of pyruvate kinase from Chlorella with different kinetic properties
Z. Naturforsch. C
46
416-422
1991
Parachlorella kessleri
-
Manually annotated by BRENDA team
Kayne, F.J.
Pyruvate kinase
The Enzymes,3rd Ed. (Boyer,P. D. ,ed. )
8
353-382
1973
Azotobacter vinelandii, Komagataeibacter xylinus, Antarctic fish, Bacillus subtilis, [Brevibacterium] flavum, Saccharomyces cerevisiae, Coprinopsis lagopus, Oryctolagus cuniculus, Schistocerca gregaria, Escherichia coli, Euglena gracilis, Cobitidae, Amylomyces rouxii, Mus musculus, Oncorhynchus mykiss, Ostreidae, Paralithodes camtschaticus, Lithobates pipiens, Rattus norvegicus, Saccharomyces pastorianus, Sus scrofa, Halothiobacillus neapolitanus, Trypanosoma brucei
-
Manually annotated by BRENDA team
Besford, R.T.; Maw, G.A.
Properties of pyruvate kinase extracted from Lycopersicon esculentum
Phytochemistry
14
677-682
1975
Solanum lycopersicum
-
Manually annotated by BRENDA team
Duggleby, R.G.; Dennis, D.T.
The characterization and regulatory properties of pyruvate kinase from cotton seeds
Arch. Biochem. Biophys.
155
270-277
1973
Gossypium hirsutum
Manually annotated by BRENDA team
Lin, M.; Turpin, D.H.; Plaxton, W.C.
Pyruvate kinase isozymes from the green alga, Selenastrum minutum. I. Purification and physical and immunological characterization
Arch. Biochem. Biophys.
269
219-227
1989
Monoraphidium minutum
Manually annotated by BRENDA team
Lin, M.; Turpin, D.H.; Plaxton, W.C.
Pyruvate kinase isozymes from the green alga, Selenastrum minutum. II. Kinetic and regulatory properties
Arch. Biochem. Biophys.
269
228-238
1989
Monoraphidium minutum
Manually annotated by BRENDA team
Knowles, V.L.; Dennis, D.T.; Plaxton, W.C.
Purification of a novel pyruvate kinase from a green alga
FEBS Lett.
259
130-132
1989
Monoraphidium minutum
-
Manually annotated by BRENDA team
Flynn, I.W.; Bowman, I.B.R.
Purification and characterization of pyruvate kinase from Trypanosoma brucei
Arch. Biochem. Biophys.
200
401-409
1980
Trypanosoma brucei
Manually annotated by BRENDA team
Ernest, I.; Opperdoes, F.R.; Michels, P.A.M.
Cloning and sequence analysis of the gene encoding pyruvate kinase in Trypanoplasma borelli
Biochem. Biophys. Res. Commun.
201
727-732
1994
Trypanoplasma borreli, Trypanoplasma borreli K-100
Manually annotated by BRENDA team
Kester, H.C.M.; Uitzetter, J.H.A.A.; De Graaff, L.H.; Visser, J.
A rapid purification procedure for pyruvate kinase from the hyphal fungus Aspergillus nidulans
Can. J. Microbiol.
34
1154-1158
1988
Aspergillus nidulans
Manually annotated by BRENDA team
Hohn, T.M.; Paznokas, J.L.
Purification and properties of two isozymes of pyruvate kinase from Mucor racemosus
J. Bacteriol.
169
3525-3530
1987
Mucor racemosus
Manually annotated by BRENDA team
Duncan, D.; McGowan, J.; Price, N.C.
Properties of pyruvate kinase from Schizosaccharomyces pombe
Biochem. Soc. Trans.
17
560-561
1989
Schizosaccharomyces pombe
-
Manually annotated by BRENDA team
Strick, C.A.; James, L.C.; O'Donnell, M.M.; Gollaher, M.G.; Franke, A.E.
The isolation and characterization of the pyruvate kinase-encoding gene from the yeast Yarrowia lipolytica [published erratum appears in Gene 1994 Mar 11;140(1):141]
Gene
118
65-72
1992
Yarrowia lipolytica (P30614), Yarrowia lipolytica
Manually annotated by BRENDA team
Sakai, H.; Suzuki, K.; Imahori, K.
Purification and properties of pyruvate kinase from Bacillus stearothermophilus
J. Biochem.
99
1157-1167
1986
Geobacillus stearothermophilus
Manually annotated by BRENDA team
De Médicis, E.; Laliberté, J.F.; Vass-Marengo, J.
Purification and properties of pyruvate kinase from Halobacterium cutirubrum
Biochim. Biophys. Acta
708
57-67
1982
Halobacterium salinarum, Halobacterium salinarum 9
-
Manually annotated by BRENDA team
Kapoor, R.; Venkitasubramanian, T.A.
Purification and properties of pyruvate kinase from Mycobacterium smegmatis
Arch. Biochem. Biophys.
225
320-330
1983
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis CDC 46
Manually annotated by BRENDA team
Evans, C.T.; Ratledge, C.
Partial purification and properties of pyruvate kinase and its regulatory role during lipid accumulation by the oleaginous yeast Rhodosporidium toruloides CBS 14
Can. J. Microbiol.
31
479-484
1985
Rhodotorula toruloides, Rhodotorula toruloides CBS 14
-
Manually annotated by BRENDA team
Garcia-Olalla, C.; Garrido-Pertierra, A.
Purification and kinetic properties of pyruvate kinase isoenzymes of Salmonella typhimurium
Biochem. J.
241
573-581
1987
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Abe, K.; Yamada, T.
Purification and properties of pyruvate kinase from Streptococcus mutans
J. Bacteriol.
149
299-305
1982
Streptococcus mutans, Streptococcus mutans JC2
Manually annotated by BRENDA team
Potter, S.; Fothergill-Gilmore, L.A.
Purification and properties of pyruvate kinase from Thermoplasma acidophilum
FEMS Microbiol. Lett.
94
235-240
1992
Thermoplasma acidophilum
-
Manually annotated by BRENDA team
Kapoor, M.
Subunit structure and some properties of pyruvate kinase of Neurospora
Can. J. Biochem.
53
109-119
1975
Neurospora crassa
Manually annotated by BRENDA team
Meixner-Monori, B.; Kubicek, C.P.; Rohr, H.
Pyruvate kinase from Aspergillus niger: a regulatory enzyme in glycolysis?
Can. J. Microbiol.
30
16-22
1984
Aspergillus niger
Manually annotated by BRENDA team
Kapoor, M.; O'Brien, M.D.
Studies of the structure--function relationships of Neurospora crassa pyruvate kinase: interaction with blue dextran--sepharose and Cibacron blue 3G-A
Can. J. Microbiol.
26
613-621
1980
Neurospora crassa
Manually annotated by BRENDA team
Terenzi, H.F.; Roselino, E.; Passeron, S.
Two types of pyruvate kinase in Mucor rouxii. Changes in the enzymatic pattern related to aerobic development
Eur. J. Biochem.
18
342-350
1971
Amylomyces rouxii
Manually annotated by BRENDA team
Chuang, D.T.; Utter, M.F.
Structural and regulatory properties of pyruvate kinase from Pseudomonas citronellolis
J. Biol. Chem.
254
8434-8441
1979
Pseudomonas citronellolis
Manually annotated by BRENDA team
Collins, L.B.; Thomas, T.D.
Pyruvate kinase of Streptococcus lactis
J. Bacteriol.
120
52-58
1974
Lactococcus lactis
Manually annotated by BRENDA team
Gibriel, A.J.; Doelle, H.W.
Investigation into pyruvate kinases from Escherichia coli K-12 grown under aerobic and anaerobic conditions
Microbios
12
179-197
1975
Escherichia coli
Manually annotated by BRENDA team
Ng, S.K.C.; Hamilton, I.R.
Purification and regulatory properties of pyruvate kinase from Veillonella parvula
J. Bacteriol.
122
1274-1282
1975
Veillonella parvula
Manually annotated by BRENDA team
Smart., J.B.; Pritchard, G.G.
Regulation of pyruvate kinase from Propionibacterium shermanii
Arch. Microbiol.
122
281-288
1979
Propionibacterium freudenreichii subsp. shermanii
-
Manually annotated by BRENDA team
Schramm, A.; Siebers, B.; Tjaden, B.; Brinkmann, H.; Hensel, R.
Pyruvate kinase of the hyperthermophilic crenarchaeote Thermoproteus tenax: physiological role and phylogenetic aspects
J. Bacteriol.
182
2001-2009
2000
Thermoproteus tenax
Manually annotated by BRENDA team
Smith, C.R.; Knowles, V.L.; Plaxton, W.C.
Purification and characterization of cytosolic pyruvate kinase from Brassica napus (rapeseed) suspension cell cultures: implications for the integration of glycolysis with nitrogen assimilation
Eur. J. Biochem.
267
4477-4485
2000
Brassica napus
Manually annotated by BRENDA team
Turner, W.L.; Plaxton, W.C.
Purification and characterization of cytosolic pyruvate kinase from banana fruit
Biochem. J.
352
875-882
2000
Musa cavendishii
-
Manually annotated by BRENDA team
Ambasht, P.K.; Kayastha, A.M.
Plant pyruvate kinase
Biol. Plant.
45
1-10
2002
Brassica rapa subsp. oleifera, Brassica napus, Ricinus communis, Cynodon dactylon, Monoraphidium minutum, Spinacia oleracea
-
Manually annotated by BRENDA team
Nairn, J.; Duncan, D.; Gray, L.M.; Urquhart, G.; Binnie, M.; Byron, O.; Fothergill-Gilmore, L.A.; Price, N.C.
Purification and characterization of pyruvate kinase from Schizosaccharomyces pombe: evidence for an unusual quaternary structure
Protein Expr. Purif.
14
247-253
1998
Schizosaccharomyces pombe (Q10208), Schizosaccharomyces pombe
Manually annotated by BRENDA team
Ernest, I.; Callens, M.; Uttaro, A.D.; Chevalier, N.; Opperdoes, F.R.; Muirhead, H.; Michels, P.A.
Pyruvate kinase of Trypanosoma brucei: overexpression, purification, and functional characterization of wild-type and mutated enzyme
Protein Expr. Purif.
13
373-382
1998
Trypanosoma brucei
Manually annotated by BRENDA team
Nishikawa, A.; Kanehira, C.; Imamura, K.
Purification and characterization of pyruvate kinase from lamprey (Entosphenus japonicus) muscle
Comp. Biochem. Physiol. B
128
159-164
2001
Lethenteron camtschaticum
Manually annotated by BRENDA team
Farrar, G.; Farrar, W.W.
Purification and properties of the pyruvate kinase isozyme M1 from the pig brain
Int. J. Biochem. Cell Biol.
27
1145-1151
1995
Sus scrofa
Manually annotated by BRENDA team
Vetter, R.A.H.; Buchholz, F.
Catalytic properties of two pyruvate kinase isoforms in Nordic krill, Meganyctiphanes norvegica, with respect to seasonal temperature adaptation
Comp. Biochem. Physiol. A
116A
1-10
1997
Meganyctiphanes norvegica
-
Manually annotated by BRENDA team
Tanaka, K.; Sakai, H.; Ohta, T.; Matsuzawa, H.
Molecular cloning of the genes for pyruvate kinase of two bacilli, Bacillus psychrophilus and Bacillus licheniformis, and comparison of the properties of the enzymes produced in Escherichia coli
Biosci. Biotechnol. Biochem.
59
1536-1542
1995
Escherichia coli, Bacillus licheniformis (P51181), Bacillus licheniformis, Sporosarcina psychrophila (P51182), Sporosarcina psychrophila
Manually annotated by BRENDA team
Ambasht, P.K.; Malhotra, O.P.; Kayastha, A.M.
Purification, characterisation and steady state kinetic properties of cytosolic pyruvate kinase free of phosphoenol pyruvate phosphatase activity from germinating mung beans (Vigna radiata L.)
Indian J. Biochem. Biophys.
33
184-194
1996
Vigna radiata
Manually annotated by BRENDA team
Singh, D.K.; Malhotra, S.P.; Singh, R.
Purification and characterization of cytosolic pyruvate kinase from developing seeds of Brassica campestris L
Indian J. Biochem. Biophys.
37
51-58
2000
Brassica rapa subsp. oleifera
Manually annotated by BRENDA team
Iliffe-Lee, E.R.; McClarty, G.
Pyruvate kinase from Chlamydia trachomatis is activated by fructose-2,6-bisphosphate
Mol. Microbiol.
44
819-828
2002
Chlamydia trachomatis
Manually annotated by BRENDA team
Maeda, T.; Saito, T.; Oguchi, Y.; Nakazawa, M.; Takeuchi, T.; Asai, T.
Expression and characterization of recombinant pyruvate kinase from Toxoplasma gondii tachyzoites
Parasitol. Res.
89
259-265
2003
Toxoplasma gondii (Q969A2), Toxoplasma gondii
Manually annotated by BRENDA team
Asanuma, N.; Hino, T.
Molecular characterization, enzyme properties and transcriptional regulation of phosphoenolpyruvate carboxykinase and pyruvate kinase in a ruminal bacterium, Selenomonas ruminantium
Microbiology
147
681-690
2001
Selenomonas ruminantium (Q9LBS6), Selenomonas ruminantium
Manually annotated by BRENDA team
Hu, Z.; Plaxton, W.C.
Purification and characterization of cytosolic pyruvate kinase from leaves of the castor oil plant
Arch. Biochem. Biophys.
333
298-307
1996
Ricinus communis
Manually annotated by BRENDA team
Wang, C.; Chiarelli, L.R.; Bianchi, P.; Abraham, D.J.; Galizzi, A.; Mattevi, A.; Zanella, A.; Valentini, G.
Human erythrocyte pyruvate kinase: characterization of the recombinant enzyme and a mutant form (R510Q) causing nonspherocytic hemolytic anemia
Blood
98
3113-3120
2001
Homo sapiens (P30613), Homo sapiens
Manually annotated by BRENDA team
Wan, J.; Blakeley, S.D.; Dennis, D.T.; Ko, K.
Import characteristics of a leucoplast pyruvate kinase are influenced by a 19-amino-acid domain within the protein
J. Biol. Chem.
270
16731-16739
1995
Ricinus communis
Manually annotated by BRENDA team
Knowles, V.L.; Smith, C.S.; Smith, C.R.; Plaxton, W.C.
Structural and regulatory properties of pyruvate kinase from the cyanobacterium Synechococcus PCC 6301
J. Biol. Chem.
276
20966-20972
2001
Synechococcus sp.
Manually annotated by BRENDA team
Susan-Resiga, D.; Nowak, T.
The Proton Transfer Step Catalyzed by Yeast Pyruvate Kinase
J. Biol. Chem.
278
12660-12671
2003
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Boles, E.; Schulte, F.; Miosga, T.; Freidel, K.; Schluter, E.; Zimmermann, F.K.; Hollenberg, C.P.; Heinisch, J.J.
Characterization of a glucose-repressed pyruvate kinase (Pyk2p) in Saccharomyces cerevisiae that is catalytically insensitive to fructose-1,6-bisphosphate
J. Bacteriol.
179
2987-2993
1997
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Zervoudakis, G.; Georgiou, C.D.; Angelopoulos, K.
Pyruvate kinase activity in crude extracts of leaves of Cynodon dactylon and other C4 plants
Russ. J. Plant Physiol.
48
171-175
2001
Amaranthus sp., Cynodon dactylon, Digitaria sanguinalis, Setaria verticillata, Sorghum halepense
-
Manually annotated by BRENDA team
Plaxton, W.C.; Smith, C.R.; Knowles, V.L.
Molecular and regulatory properties of leucoplast pyruvate kinase from Brassica napus (rapeseed) suspension cells
Arch. Biochem. Biophys.
400
54-62
2002
Brassica napus
Manually annotated by BRENDA team
Arai, A.; Murakami, S.; Nakajima, M.
Purification and characterization of a thermostable pyruvate kinase from the actinomycete Microbispora thermodiastatica
Biosci. Biotechnol. Biochem.
61
40-45
1997
Microbispora rosea subsp. aerata
Manually annotated by BRENDA team
Zervoudakis, G.; Georgiou, C.D.; Mavroidis, M.; Kokolakis, G.; Angelopoulos, K.
Characterization of purified leaf cytosolic pyruvate kinase from the C4 plant Cynodon dactylon
Physiol. Plant.
101
563-569
1997
Cynodon dactylon
-
Manually annotated by BRENDA team
Fothergill-Gillmore, L.A.; Rigden, D.J.; Michels, P.A.; Phillips, S.E.
Leishmania pyruvate kinase: the crystal structure reveals the structural basis of its unique regulatory properties
Biochem. Soc. Trans.
28
186-190
2000
Leishmania sp.
Manually annotated by BRENDA team
Mattevi, A.; Valentini, G.; Rizzi, M.; Speranza, M.L.; Bolognesi, M.; Coda, A.
Crystal structure of Escherichia coli pyruvate kinase type I: molecular basis of the allosteric transition
Structure
3
729-741
1995
Escherichia coli
Manually annotated by BRENDA team
Boiteux, A.; Markus, M.; Plesser, T.; Hess, B.; Malcovati, M.
Analysis of progress curves. Interaction of pyruvate kinase from Escherichia coli with fructose 1,6-bisphosphate and calcium ions
Biochem. J.
211
631-640
1983
Escherichia coli
Manually annotated by BRENDA team
Yilmaz, S.; Ozan, S.; Ozercan, I.H.
Comparison of pyruvate kinase variants from breast tumor and normal breast
Arch. Med. Res.
34
315-324
2003
Homo sapiens
Manually annotated by BRENDA team
Chan, M.; Sim, T.S.
Functional analysis, overexpression, and kinetic characterization of pyruvate kinase from Plasmodium falciparum
Biochem. Biophys. Res. Commun.
326
188-196
2005
Plasmodium falciparum
Manually annotated by BRENDA team
Susan-Resiga, D.; Nowak, T.
Proton donor in yeast pyruvate kinase: chemical and kinetic properties of the active site Thr 298 to Cys mutant
Biochemistry
43
15230-15245
2004
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Dombrauckas, J.D.; Santarsiero, B.D.; Mesecar, A.D.
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
Biochemistry
44
9417-9429
2005
Homo sapiens (P14618), Homo sapiens
Manually annotated by BRENDA team
Feksa, L.R.; Cornelio, A.; Dutra-Filho, C.S.; De Souza Wyse, A.T.; Wajner, M.; Wannmacher, C.M.
Inhibition of pyruvate kinase activity by cystine in brain cortex of rats
Brain Res.
1012
93-100
2004
Rattus norvegicus
Manually annotated by BRENDA team
Feksa, L.R.; Cornelio, A.R.; Dutra-Filho, C.S.; de Souza Wyse, A.T.; Wajner, M.; Wannmacher, C.M.
Characterization of the inhibition of pyruvate kinase caused by phenylalanine and phenylpyruvate in rat brain cortex
Brain Res.
968
199-205
2003
Rattus norvegicus
Manually annotated by BRENDA team
Ohta, S.; Nishikawa, A.; Imamura, K.
Molecular cloning and expression of pyruvate kinase from globefish (Fugu rubripes)skeletal muscle
Comp. Biochem. Physiol. B
135
397-405
2003
Takifugu rubripes
Manually annotated by BRENDA team
Lemos, D.; Salomon, M.; Gomes, V.; Phan, V.N.; Buchholz, F.
Citrate synthase and pyruvate kinase activities during early life stages of the shrimp Farfantepenaeus paulensis (Crustacea, Decapoda, Penaeidae): effects of development and temperature
Comp. Biochem. Physiol. B
135
707-719
2003
Penaeus paulensis
Manually annotated by BRENDA team
Ramirez-Silva, L.; Oria-Hernandez, J.
Selectivity of pyruvate kinase for Na+ and K+ in water/dimethylsulfoxide mixtures
Eur. J. Biochem.
270
2377-2385
2003
Oryctolagus cuniculus
Manually annotated by BRENDA team
Saavedra, E.; Olivos, A.; Encalada, R.; Moreno-Sanchez, R.
Entamoeba histolytica: kinetic and molecular evidence of a previously unidentified pyruvate kinase
Exp. Parasitol.
106
11-21
2004
Entamoeba histolytica
Manually annotated by BRENDA team
Johnsen, U.; Hansen, T.; Schoenheit, P.
Comparative analysis of pyruvate kinases from the hyperthermophilic archaea Archaeoglobus fulgidus, Aeropyrum pernix, and Pyrobaculum aerophilum and the hyperthermophilic bacterium Thermotoga maritima. Unusual regulatory properties in hyperthermophilic archaea
J. Biol. Chem.
278
25417-25427
2003
Aeropyrum pernix, Archaeoglobus fulgidus, Pyrobaculum aerophilum, Thermotoga maritima, Archaeoglobus fulgidus 7324
Manually annotated by BRENDA team
Stamm, I.; Lottspeich, F.; Plaga, W.
The pyruvate kinase of Stigmatella aurantiaca is an indole binding protein and essential for development
Mol. Microbiol.
56
1386-1395
2005
Stigmatella aurantiaca (Q8GQS6), Stigmatella aurantiaca
Manually annotated by BRENDA team
Papadopoulos, A.I.; Anagnostis, A.; Lazarou, D.
Effect of insecticide injection on pyruvate kinase of the insect Tenebrio molitor (Coleopteran)
Pestic. Biochem. Physiol.
82
115-124
2005
Tenebrio molitor
-
Manually annotated by BRENDA team
Suzuki, K.; Ito, S.; Shimizu-Ibuka, A.; Sakai, H.
Crystallization and preliminary X-ray analysis of pyruvate kinase from Bacillus stearothermophilus
Acta Crystallogr. Sect. F
61
759-761
2005
Geobacillus stearothermophilus
Manually annotated by BRENDA team
Portela, P.; Moreno, S.; Rossi, S.
Characterization of yeast pyruvate kinase 1 as a protein kinase A substrate, and specificity of the phosphorylation site sequence in the whole protein
Biochem. J.
396
117-126
2006
Saccharomyces cerevisiae, Saccharomyces cerevisiae JT20454
Manually annotated by BRENDA team
Williams, R.; Holyoak, T.; McDonald, G.; Gui, C.; Fenton, A.W.
Differentiating a ligands chemical requirements for allosteric interactions from those for protein binding. Phenylalanine inhibition of pyruvate kinase
Biochemistry
45
5421-5429
2006
Oryctolagus cuniculus (P11974)
Manually annotated by BRENDA team
Pan, Z.; Zhu, T.; Domagalski, N.; Khan, S.; Koepsel, R.R.; Domach, M.M.; Ataai, M.M.
Regulating expression of pyruvate kinase in Bacillus subtilis for control of growth rate and formation of acidic byproducts
Biotechnol. Prog.
22
1451-1455
2006
Bacillus subtilis, Bacillus subtilis 168
Manually annotated by BRENDA team
Stetak, A.; Veress, R.; Ovadi, J.; Csermely, P.; Keri, G.; Ullrich, A.
Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death
Cancer Res.
67
1602-1608
2007
Homo sapiens
Manually annotated by BRENDA team
Gomez-Milan, E.; Cardenete, G.; Sanchez-Muros, M.J.
Annual variations in the specific activity of fructose 1,6-bisphosphatase, alanine aminotransferase and pyruvate kinase in the Sparus aurata liver
Comp. Biochem. Physiol. B
147B
49-55
2007
Sparus aurata
-
Manually annotated by BRENDA team
Kumar, Y.; Tapuria, N.; Kirmani, N.; Davidson, B.R.
Tumour M2-pyruvate kinase: a gastrointestinal cancer marker
Eur. J. Gastroenterol. Hepatol.
19
265-276
2007
Homo sapiens
Manually annotated by BRENDA team
Meza, N.W.; Quintana-Bustamante, O.; Puyet, A.; Rio, P.; Navarro, S.; Diez, A.; Bueren, J.A.; Bautista, J.M.; Segovia, J.C.
In vitro and in vivo expression of human erythrocyte pyruvate kinase in erythroid cells: a gene therapy approach
Hum. Gene Ther.
18
502-514
2007
Homo sapiens
Manually annotated by BRENDA team
Feksa, L.R.; Cornelio, A.; Dutra-Filho, C.S.; Wyse, A.T.; Wajner, M.; Wannmacher, C.M.
The effects of the interactions between amino acids on pyruvate kinase activity from the brain cortex of young rats
Int. J. Dev. Neurosci.
23
509-514
2005
Rattus norvegicus
Manually annotated by BRENDA team
Labbe, M.; Peroval, M.; Bourdieu, C.; Girard-Misguich, F.; Pery, P.
Eimeria tenella enolase and pyruvate kinase: a likely role in glycolysis and in others functions
Int. J. Parasitol.
36
1443-1452
2006
Eimeria tenella (O44006), Eimeria tenella, Eimeria tenella PaPt36 (O44006)
Manually annotated by BRENDA team
Pendergrass, D.C.; Williams, R.; Blair, J.B.; Fenton, A.W.
Mining for allosteric information: natural mutations and positional sequence conservation in pyruvate kinase
IUBMB Life
58
31-38
2006
Homo sapiens
Manually annotated by BRENDA team
Sakai, H.
Mutagenesis of the active site lysine 221 of the pyruvate kinase from Bacillus stearothermophilus
J. Biochem.
137
141-145
2005
Geobacillus stearothermophilus
Manually annotated by BRENDA team
Oria-Hernandez, J.; Cabrera, N.; Perez-Montfort, R.; Ramirez-Silva, L.
Pyruvate kinase revisited: the activating effect of K+
J. Biol. Chem.
280
37924-37929
2005
Homo sapiens
Manually annotated by BRENDA team
Hoshino, A.; Hirst, J.A.; Fujii, H.
Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase
J. Biol. Chem.
282
17706-17711
2007
Mus musculus
Manually annotated by BRENDA team
Peltier, S.; Burelle, Y.; Novel-Chate, V.; Demaison, L.; Verdys, M.; Saks, V.; Keriel, C.; Leverve, X.M.
Effect of exogenous adenosine and monensin on glycolytic flux in isolated perfused normoxic rat hearts: role of pyruvate kinase
Mol. Cell. Biochem.
277
55-61
2005
Rattus norvegicus
Manually annotated by BRENDA team
Narli, N.; Satar, M.; Kayrin, L.; Yapicioglu, H.; Oezlue, F.; Budgayci, R.
The activity and kinetics of pyruvate kinase in hypoxic newborns
Pediatr. Hematol. Oncol.
22
567-573
2005
Homo sapiens
Manually annotated by BRENDA team
Andre, C.; Froehlich, J.E.; Moll, M.R.; Benning, C.
A heteromeric plastidic pyruvate kinase complex involved in seed oil biosynthesis in Arabidopsis
Plant Cell
19
2006-2022
2007
Arabidopsis thaliana
Manually annotated by BRENDA team
Turner, W.L.; Knowles, V.L.; Plaxton, W.C.
Cytosolic pyruvate kinase: subunit composition, activity, and amount in developing castor and soybean seeds, and biochemical characterization of the purified castor seed enzyme
Planta
222
1051-1062
2005
Ricinus communis, Glycine max
Manually annotated by BRENDA team
Feiden, S.; Stypa, H.; Wolfrum, U.; Wegener, G.; Kamp, G.
A novel pyruvate kinase (PK-S) from boar spermatozoa is localized at the fibrous sheath and the acrosome
Reproduction
134
81-95
2007
Sus scrofa
Manually annotated by BRENDA team
Palop, A.; Rutherford, G.C.; Marquis, R.E.
Inactivation of enzymes within spores of Bacillus megaterium ATCC 19213 by hydroperoxides
Can. J. Microbiol.
44
465-470
1998
Priestia megaterium
Manually annotated by BRENDA team
Asanuma, N.; Kanada, K.; Hino, T.
Molecular properties and transcriptional control of the phosphofructokinase and pyruvate kinase genes in a ruminal bacterium, Streptococcus bovis
Anaerobe
14
237-241
2008
Streptococcus equinus
Manually annotated by BRENDA team
Iori, E.; Millioni, R.; Puricelli, L.; Arrigoni, G.; Lenzini, L.; Trevisan, R.; James, P.; Rossi, G.P.; Pinna, L.A.; Tessari, P.
Glycolytic enzyme expression and pyruvate kinase activity in cultured fibroblasts from type 1 diabetic patients with and without nephropathy
Biochim. Biophys. Acta
1782
627-633
2008
Homo sapiens (P14618), Homo sapiens
Manually annotated by BRENDA team
Ogasawara, Y.; Funakoshi, M.; Ishii, K.
Pyruvate kinase is protected by glutathione-dependent redox balance in human red blood cells exposed to reactive oxygen species
Biol. Pharm. Bull.
31
1875-1881
2008
Homo sapiens
Manually annotated by BRENDA team
Min-Oo, G.; Tam, M.; Stevenson, M.M.; Gros, P.
Pyruvate kinase deficiency: correlation between enzyme activity, extent of hemolytic anemia and protection against malaria in independent mouse mutants
Blood Cells Mol. Dis.
39
63-69
2007
Mus musculus
Manually annotated by BRENDA team
Haug, U.; Hundt, S.; Brenner, H.
Sensitivity and specificity of faecal tumour M2 pyruvate kinase for detection of colorectal adenomas in a large screening study
Br. J. Cancer
99
133-135
2008
Homo sapiens
Manually annotated by BRENDA team
Gomez-Milan, E.; Cardenete, G.; Sanchez-Muros, M.J.
Annual variations in the specific activity of fructose 1,6-bisphosphatase, alanine aminotransferase and pyruvate kinase in the Sparus aurata liver
Comp. Biochem. Physiol. B
147
49-55
2007
Sparus aurata
Manually annotated by BRENDA team
Echigoya, Y.; Sato, T.; Itou, T.; Endo, H.; Sakai, T.
Molecular characterization and expression of the equine M(1) and M(2)-pyruvate kinase gene
Comp. Biochem. Physiol. B
151
125-132
2008
Equus caballus (B3IVM0), Equus caballus (B3IVM1), Equus caballus
Manually annotated by BRENDA team
Aisaki, K.; Aizawa, S.; Fujii, H.; Kanno, J.; Kanno, H.
Glycolytic inhibition by mutation of pyruvate kinase gene increases oxidative stress and causes apoptosis of a pyruvate kinase deficient cell line
Exp. Hematol.
35
1190-1200
2007
Homo sapiens
Manually annotated by BRENDA team
Dharmarajan, L.; Case, C.L.; Dunten, P.; Mukhopadhyay, B.
Tyr235 of human cytosolic phosphoenolpyruvate carboxykinase influences catalysis through an anion-quadrupole interaction with phosphoenolpyruvate carboxylate
FEBS J.
275
5810-5819
2008
Homo sapiens (P14618)
Manually annotated by BRENDA team
Wu, X.; Zhou, Y.; Zhang, K.; Liu, Q.; Guo, D.
Isoform-specific interaction of pyruvate kinase with hepatitis C virus NS5B
FEBS Lett.
582
2155-2160
2008
Homo sapiens (P14618)
Manually annotated by BRENDA team
Sandoval, W.; Isea, R.; Rodriguez, E.; Ramirez, J.L.
A biochemical and genetic study of Leishmania donovani pyruvate kinase
Gene
424
25-32
2008
Leishmania donovani (A7LIU4), Leishmania donovani
Manually annotated by BRENDA team
Shimada, N.; Shinagawa, T.; Ishii, S.
Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein
Genes Cells
13
245-254
2008
Homo sapiens
Manually annotated by BRENDA team
Derks, T.G.; van Dijk, T.H.; Grefhorst, A.; Rake, J.; Smit, G.P.; Kuipers, F.; Reijngoud, D.
Inhibition of mitochondrial fatty acid oxidation in vivo only slightly suppresses gluconeogenesis but enhances clearance of glucose in mice
Hepatology
47
1032-1042
2008
Mus musculus
Manually annotated by BRENDA team
Siwko, S.; Mochly-Rosen, D.
Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase
Int. J. Biochem. Cell Biol.
39
978-987
2007
Homo sapiens
Manually annotated by BRENDA team
Spoden, G.A.; Mazurek, S.; Morandell, D.; Bacher, N.; Ausserlechner, M.J.; Jansen-Duerr, P.; Eigenbrodt, E.; Zwerschke, W.
Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation
Int. J. Cancer
123
312-321
2008
Homo sapiens
Manually annotated by BRENDA team
Suzuki, K.; Ito, S.; Shimizu-Ibuka, A.; Sakai, H.
Crystal structure of pyruvate kinase from Geobacillus stearothermophilus
J. Biochem.
144
305-312
2008
Geobacillus stearothermophilus (Q02499), Geobacillus stearothermophilus
Manually annotated by BRENDA team
Tulloch, L.B.; Morgan, H.P.; Hannaert, V.; Michels, P.A.; Fothergill-Gilmore, L.A.; Walkinshaw, M.D.
Sulphate removal induces a major conformational change in Leishmania mexicana pyruvate kinase in the crystalline state
J. Mol. Biol.
383
615-626
2008
Leishmania mexicana (Q27686), Leishmania mexicana
Manually annotated by BRENDA team
Ameho, C.K.; Chen, C.Y.; Smith, D.; Sanchez-Moreno, C.; Milbury, P.E.; Blumberg, J.B.
Antioxidant activity and metabolite profile of quercetin in vitamin-E-depleted rats
J. Nutr. Biochem.
19
467-474
2008
Rattus norvegicus
Manually annotated by BRENDA team
Detaille, D.; Sanchez, C.; Sanz, N.; Lopez-Novoa, J.M.; Leverve, X.; El-Mir, M.Y.
Interrelation between the inhibition of glycolytic flux by silibinin and the lowering of mitochondrial ROS production in perifused rat hepatocytes
Life Sci.
82
1070-1076
2008
Rattus norvegicus
Manually annotated by BRENDA team
Doran, P.; OConnell, K.; Gannon, J.; Kavanagh, M.; Ohlendieck, K.
Opposite pathobiochemical fate of pyruvate kinase and adenylate kinase in aged rat skeletal muscle as revealed by proteomic DIGE analysis
Proteomics
8
364-377
2008
Rattus norvegicus
Manually annotated by BRENDA team
Dimou, M.; Paunescu, A.; Aivalakis, G.; Flemetakis, E.; Katinakis, P.
Co-localization of carbonic anhydrase and phosphoenolpyruvate carboxylase and localization of pyruvate kinase in roots and hypocotyls of etiolated Glycine max seedlings
Int. J. Mol. Sci.
10
2896-2910
2009
Glycine max (Q5F2M7), Glycine max
Manually annotated by BRENDA team
Sawada, K.; Taki, A.; Yamakawa, T.; Seki, M.
Key role for transketolase activity in erythritol production by Trichosporonoides megachiliensis SN-G42
J. Biosci. Bioeng.
108
385-390
2009
Moniliella megachiliensis, Moniliella megachiliensis SN-G42
Manually annotated by BRENDA team
Lepper, T.W.; Oliveira, E.; Koch, G.D.; Berlese, D.B.; Feksa, L.R.
Lead inhibits in vitro creatine kinase and pyruvate kinase activity in brain cortex of rats
Toxicol. In Vitro
24
1045-1051
2009
Rattus norvegicus
Manually annotated by BRENDA team
Lee, J.C.
Modulation of allostery of pyruvate kinase by shifting of an ensemble of microstates
Acta Biochim. Biophys. Sin.
40
663-669
2008
Oryctolagus cuniculus (P11974)
Manually annotated by BRENDA team
Mazurek, S.; Drexler, H.C.; Troppmair, J.; Eigenbrodt, E.; Rapp, U.R.
Regulation of pyruvate kinase type M2 by A-Raf: a possible glycolytic stop or go mechanism
Anticancer Res.
27
3963-3971
2008
Mus musculus
Manually annotated by BRENDA team
Pan, Z.; Cunningham, D.S.; Zhu, T.; Ye, K.; Koepsel, R.R.; Domach, M.M.; Ataai, M.M.
Enhanced recombinant protein production in pyruvate kinase mutant of Bacillus subtilis
Appl. Microbiol. Biotechnol.
85
1769-1778
2010
Bacillus subtilis, Bacillus subtilis 168
Manually annotated by BRENDA team
Fenton, A.W.; Hutchinson, M.
The pH dependence of the allosteric response of human liver pyruvate kinase to fructose-1,6-bisphosphate, ATP, and alanine
Arch. Biochem. Biophys.
484
16-23
2009
Homo sapiens
Manually annotated by BRENDA team
Pizzuto, R.; Paventi, G.; Atlante, A.; Passarella, S.
Pyruvate kinase in pig liver mitochondria
Arch. Biochem. Biophys.
495
42-48
2010
Sus scrofa
Manually annotated by BRENDA team
Barrs, V.R.; Giger, U.; Wilson, B.; Chan, C.T.; Lingard, A.E.; Tran, L.; Seng, A.; Canfield, P.J.; Beatty, J.A.
Erythrocytic pyruvate kinase deficiency and AB blood types in Australian Abyssinian and Somali cats
Aust. Vet. J.
87
39-44
2009
Felis catus
Manually annotated by BRENDA team
Vander Heiden, M.G.; Christofk, H.R.; Schuman, E.; Subtelny, A.O.; Sharfi, H.; Harlow, E.E.; Xian, J.; Cantley, L.C.
Identification of small molecule inhibitors of pyruvate kinase M2
Biochem. Pharmacol.
79
1118-1124
2010
Homo sapiens
Manually annotated by BRENDA team
Fenton, A.W.; Tang, Q.
An activating interaction between the unphosphorylated N-terminus of human liver pyruvate kinase and the main body of the protein is interrupted by phosphorylation
Biochemistry
48
3816-3818
2009
Homo sapiens
Manually annotated by BRENDA team
Herman, P.; Lee, J.C.
Functional energetic landscape in the allosteric regulation of muscle pyruvate kinase. 1. Calorimetric study
Biochemistry
48
9448-9455
2009
Oryctolagus cuniculus
Manually annotated by BRENDA team
Herman, P.; Lee, J.C.
Functional energetic landscape in the allosteric regulation of muscle pyruvate kinase. 2. Fluorescence study
Biochemistry
48
9456-9465
2009
Oryctolagus cuniculus
Manually annotated by BRENDA team
Herman, P.; Lee, J.C.
Functional energetic landscape in the allosteric regulation of muscle pyruvate kinase. 3. Mechanism
Biochemistry
48
9466-9470
2009
Oryctolagus cuniculus
Manually annotated by BRENDA team
Zhu, T.; Bailey, M.F.; Angley, L.M.; Cooper, T.F.; Dobson, R.C.
The quaternary structure of pyruvate kinase type 1 from Escherichia coli at low nanomolar concentrations
Biochimie
92
116-120
2010
Escherichia coli
Manually annotated by BRENDA team
Murakami, K.; Tsubouchi, R.; Fukayama, M.; Qiao, S.; Yoshino, M.
Iron-dependent oxidative inactivation with affinity cleavage of pyruvate kinase
Biol. Trace Elem. Res.
130
31-38
2009
Oryctolagus cuniculus
Manually annotated by BRENDA team
Yavarian, M.; Karimi, M.; Shahriary, M.; Afrasiabi, A.
Prevalence of pyruvate kinase deficiency among the south Iranian population: Quantitative assay and molecular analysis
Blood Cells Mol. Dis.
40
308-311
2008
Homo sapiens
Manually annotated by BRENDA team
Aloysius, M.M.; Zaitoun, A.M.; Bates, T.E.; Albasri, A.; Ilyas, M.; Rowlands, B.J.; Lobo, D.N.
Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia
BMC Cancer
9
327
2009
Homo sapiens
Manually annotated by BRENDA team
Finkenstedt, A.; Bianchi, P.; Theurl, I.; Vogel, W.; Witcher, D.R.; Wroblewski, V.J.; Murphy, A.T.; Zanella, A.; Zoller, H.
Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency
Br. J. Haematol.
144
789-793
2009
Homo sapiens
Manually annotated by BRENDA team
Ryu, H.; Walker, J.K.; Kim, S.; Koo, N.; Barak, L.S.; Noguchi, T.; Kang, B.Y.; Kim, K.M.
Regulation of M2-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation
Br. J. Pharmacol.
154
1035-1046
2008
Rattus norvegicus
Manually annotated by BRENDA team
Zhang, Z.; Liu, Q.; Che, Y.; Yuan, X.; Dai, L.; Zeng, B.; Jiao, G.; Zhang, Y.; Wu, X.; Yu, Y.; Zhang, Y.; Yang, R.
Antigen presentation by dendritic cells in tumors is disrupted by altered metabolism that involves pyruvate kinase M2 and its interaction with SOCS3
Cancer Res.
70
89-98
2010
Mus musculus
Manually annotated by BRENDA team
Kedar, P.; Hamada, T.; Warang, P.; Nadkarni, A.; Shimizu, K.; Fujji, H.; Ghosh, K.; Kanno, H.; Colah, R.
Spectrum of novel mutations in the human PKLR gene in pyruvate kinase-deficient Indian patients with heterogeneous clinical phenotypes
Clin. Genet.
75
157-162
2009
Homo sapiens
Manually annotated by BRENDA team
Koss, K.; Maxton, D.; Jankowski, J.
Faecal dimeric M2 pyruvate kinase in colorectal cancer and polyps correlates with tumour staging and surgical intervention
Colorectal Dis.
10
244-248
2008
Homo sapiens
Manually annotated by BRENDA team
Gao, S.; Bao, J.; Gu, X.; Xin, X.; Chen, C.; Ryu, D.
Substrate promiscuity of pyruvate kinase on various deoxynucleoside diphosphates for synthesis of deoxynucleoside triphosphates
Enzyme Microb. Technol.
43
455-459
2008
Bacillus sp. (in: Bacteria), Zymomonas mobilis, Oryctolagus cuniculus (P11974)
-
Manually annotated by BRENDA team
O’Connell, K.; Doran, P.; Gannon, J.; Ohlendieck, K.
Lectin-based proteomic profiling of aged skeletal muscle: decreased pyruvate kinase isozyme M1 exhibits drastically increased levels of N-glycosylation
Eur. J. Cell Biol.
87
793-805
2008
Rattus norvegicus
Manually annotated by BRENDA team
Johnson, M.W.; Maestranzi, S.; Duffy, A.M.; Dewar, D.H.; Ciclitira, P.J.; Sherwood, R.A.; Nicholls, J.R.
Faecal M2-pyruvate kinase: a novel, noninvasive marker of ileal pouch inflammation
Eur. J. Gastroenterol. Hepatol.
21
544-550
2009
Homo sapiens
Manually annotated by BRENDA team
Spoden, G.A.; Rostek, U.; Lechner, S.; Mitterberger, M.; Mazurek, S.; Zwerschke, W.
Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply
Exp. Cell Res.
315
2765-2774
2009
Mus musculus
Manually annotated by BRENDA team
Oka, H.; Tabara, A.; Fujisawa, K.; Jinnai, M.; Nakajima, R.; Arai, S.; Ishihara, C.; Tsuji, M.
Babesia rodhaini: the protective effect of pyruvate kinase deficiency in mice
Exp. Parasitol.
120
290-294
2008
Mus musculus
Manually annotated by BRENDA team
van Wijk, R.; Huizinga, E.G.; van Wesel, A.C.; van Oirschot, B.A.; Hadders, M.A.; van Solinge, W.W.
Fifteen novel mutations in PKLR associated with pyruvate kinase (PK) deficiency: structural implications of amino acid substitutions in PK
Hum. Mutat.
30
446-453
2009
Homo sapiens
Manually annotated by BRENDA team
Kim, J.Y.; Kim, D.Y.; Ro, J.Y.
Granule formation in NGF-cultured mast cells is associated with expressions of pyruvate kinase type M2 and annexin I proteins
Int. Arch. Allergy Immunol.
146
287-297
2008
Homo sapiens
Manually annotated by BRENDA team
Lee, J.; Kim, H.K.; Han, Y.M.; Kim, J.
Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription
Int. J. Biochem. Cell Biol.
40
1043-1054
2008
Mus musculus
Manually annotated by BRENDA team
Wong, T.S.; Liu, X.B.; Chung-Wai Ho, A.; Po-Wing Yuen, A.; Wai-Man Ng, R.; Ignace Wei, W.
Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling
Int. J. Cancer
123
251-257
2008
Homo sapiens
Manually annotated by BRENDA team
Cunningham, D.S.; Liu, Z.; Domagalski, N.; Koepsel, R.R.; Ataai, M.M.; Domach, M.M.
Pyruvate kinase-deficient Escherichia coli exhibits increased plasmid copy number and cyclic AMP levels
J. Bacteriol.
191
3041-3049
2009
Escherichia coli, Escherichia coli JM101
Manually annotated by BRENDA team
Chavadi, S.; Wooff, E.; Coldham, N.G.; Sritharan, M.; Hewinson, R.G.; Gordon, S.V.; Wheeler, P.R.
Global effects of inactivation of the pyruvate kinase gene in the Mycobacterium tuberculosis complex
J. Bacteriol.
191
7545-7553
2009
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team
Saito, T.; Nishi, M.; Lim, M.I.; Wu, B.; Maeda, T.; Hashimoto, H.; Takeuchi, T.; Roos, D.S.; Asai, T.
A novel GDP-dependent pyruvate kinase isozyme from Toxoplasma gondii localizes to both the apicoplast and the mitochondrion
J. Biol. Chem.
283
14041-14052
2008
Toxoplasma gondii
Manually annotated by BRENDA team
Akhtar, K.; Gupta, V.; Koul, A.; Alam, N.; Bhat, R.; Bamezai, R.N.
Differential behavior of missense mutations in the intersubunit contact domain of the human pyruvate kinase M2 isozyme
J. Biol. Chem.
284
11971-11981
2009
Homo sapiens (P14618), Homo sapiens
Manually annotated by BRENDA team
Spoden, G.A.; Morandell, D.; Ehehalt, D.; Fiedler, M.; Jansen-Duerr, P.; Hermann, M.; Zwerschke, W.
The SUMO-E3 ligase PIAS3 targets pyruvate kinase M2
J. Cell. Biochem.
107
293-302
2009
Homo sapiens
Manually annotated by BRENDA team
Ervens, J.; Fuchs, H.; Niemann, V.T.; Hoffmeister, B.
Pyruvate kinase isoenzyme M2 is not of diagnostic relevance as a marker for oral cancer
J. Craniomaxillofac. Surg.
36
89-94
2008
Homo sapiens
Manually annotated by BRENDA team
Kohn, B.; Fumi, C.
Clinical course of pyruvate kinase deficiency in Abyssinian and Somali cats
J. Feline Med. Surg.
10
145-153
2008
Felis catus
Manually annotated by BRENDA team
Ayi, K.; Liles, W.C.; Gros, P.; Kain, K.C.
Adenosine triphosphate depletion of erythrocytes simulates the phenotype associated with pyruvate kinase deficiency and confers protection against Plasmodium falciparum in vitro
J. Infect. Dis.
200
1289-1299
2009
Homo sapiens
Manually annotated by BRENDA team
Boxer, M.B.; Jiang, J.K.; Vander Heiden, M.G.; Shen, M.; Skoumbourdis, A.P.; Southall, N.; Veith, H.; Leister, W.; Austin, C.P.; Park, H.W.; Inglese, J.; Cantley, L.C.; Auld, D.S.; Thomas, C.J.
Evaluation of substituted N,N’-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase
J. Med. Chem.
53
1048-1055
2009
Homo sapiens
Manually annotated by BRENDA team
Delwing, D.; Delwing de Lima, D.; Scolaro, B.; Kuss, G.G.; Cruz, J.G.; Wyse, A.T.
Protective effect of antioxidants on cerebrum oxidative damage caused by arginine on pyruvate kinase activity
Metab. Brain Dis.
24
469-479
2009
Rattus norvegicus
Manually annotated by BRENDA team
Becker, J.; Klopprogge, C.; Wittmann, C.
Metabolic responses to pyruvate kinase deletion in lysine producing Corynebacterium glutamicum
Microb. Cell Fact.
7
8-8
2008
Corynebacterium glutamicum
Manually annotated by BRENDA team
Martinez-Balibrea, E.; Plasencia, C.; Gines, A.; Martinez-Cardus, A.; Musulen, E.; Aguilera, R.; Manzano, J.L.; Neamati, N.; Abad, A.
A proteomic approach links decreased pyruvate kinase M2 expression to oxaliplatin resistance in patients with colorectal cancer and in human cell lines
Mol. Cancer Ther.
8
771-778
2009
Homo sapiens
Manually annotated by BRENDA team
Meza, N.W.; Alonso-Ferrero, M.E.; Navarro, S.; Quintana-Bustamante, O.; Valeri, A.; Garcia-Gomez, M.; Bueren, J.A.; Bautista, J.M.; Segovia, J.C.
Rescue of pyruvate kinase deficiency in mice by gene therapy using the human isoenzyme
Mol. Ther.
17
2000-2009
2009
Homo sapiens
Manually annotated by BRENDA team
Ayi, K.; Min-Oo, G.; Serghides, L.; Crockett, M.; Kirby-Allen, M.; Quirt, I.; Gros, P.; Kain, K.C.
Pyruvate kinase deficiency and malaria
N. Engl. J. Med.
358
1805-1810
2008
Homo sapiens
Manually annotated by BRENDA team
Christofk, H.R.; Vander Heiden, M.G.; Wu, N.; Asara, J.M.; Cantley, L.C.
Pyruvate kinase M2 is a phosphotyrosine-binding protein
Nature
452
181-186
2008
Homo sapiens (P14618), Homo sapiens
Manually annotated by BRENDA team
Christofk, H.R.; Vander Heiden, M.G.; Harris, M.H.; Ramanathan, A.; Gerszten, R.E.; Wei, R.; Fleming, M.D.; Schreiber, S.L.; Cantley, L.C.
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Nature
452
230-233
2008
Homo sapiens
Manually annotated by BRENDA team
David, C.J.; Chen, M.; Assanah, M.; Canoll, P.; Manley, J.L.
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
Nature
463
364-368
2010
Mus musculus
Manually annotated by BRENDA team
Ishida, A.; Noda, Y.; Ueda, T.
Synaptic vesicle-bound pyruvate kinase can support vesicular glutamate uptake
Neurochem. Res.
34
807-818
2009
Rattus norvegicus
Manually annotated by BRENDA team
Maeda, T.; Saito, T.; Harb, O.S.; Roos, D.S.; Takeo, S.; Suzuki, H.; Tsuboi, T.; Takeuchi, T.; Asai, T.
Pyruvate kinase type-II isozyme in Plasmodium falciparum localizes to the apicoplast
Parasitol. Int.
58
101-105
2009
Plasmodium falciparum (C6KTA4), Plasmodium falciparum
Manually annotated by BRENDA team
Titapiwatanakun, R.; Hoyer, J.D.; Crain, K.; Arndt, C.A.
Relative red blood cell enzyme levels as a clue to the diagnosis of pyruvate kinase deficiency
Pediatr. Blood Cancer
51
819-821
2008
Homo sapiens
Manually annotated by BRENDA team
Oliver, S.N.; Lunn, J.E.; Urbanczyk-Wochniak, E.; Lytovchenko, A.; van Dongen, J.T.; Faix, B.; Schmaelzlin, E.; Fernie, A.R.; Geigenberger, P.
Decreased expression of cytosolic pyruvate kinase in potato tubers leads to a decline in pyruvate resulting in an in vivo repression of the alternative oxidase
Plant Physiol.
148
1640-1654
2008
Solanum tuberosum (Q3S1N4), Solanum tuberosum
Manually annotated by BRENDA team
Feiden, S.; Wolfrum, U.; Wegener, G.; Kamp, G.
Expression and compartmentalisation of the glycolytic enzymes GAPDH and pyruvate kinase in boar spermatogenesis
Reprod. Fertil. Dev.
20
713-723
2008
Sus scrofa
Manually annotated by BRENDA team
Ferguson, E.C.; Rathmell, J.C.
New roles for pyruvate kinase M2: working out the Warburg effect
Trends Biochem. Sci.
33
359-362
2008
Homo sapiens
Manually annotated by BRENDA team
Axerio-Cilies, P.; See, R.H.; Zoraghi, R.; Worral, L.; Lian, T.; Stoynov, N.; Jiang, J.; Kaur, S.; Jackson, L.; Gong, H.; Swayze, R.; Amandoron, E.; Kumar, N.S.; Moreau, A.; Hsing, M.; Strynadka, N.C.; McMaster, W.R.; Finlay, B.B.; Foster, L.J.; Young, R.N.; Reiner, N.E.; Cherkasov, A.
Cheminformatics-driven discovery of selective, nanomolar inhibitors for staphylococcal pyruvate kinase
ACS Chem. Biol.
7
350-359
2012
Staphylococcus aureus
Manually annotated by BRENDA team
Labes, A.; Schoenheit, P.
Sugar utilization in the hyperthermophilic, sulfate-reducing archaeon Archaeoglobus fulgidus strain 7324: starch degradation to acetate and CO2 via a modified Embden-Meyerhof pathway and acetyl-CoA synthetase (ADP-forming)
Arch. Microbiol.
176
329-338
2001
Archaeoglobus fulgidus, Archaeoglobus fulgidus 7324
Manually annotated by BRENDA team
Morgan, H.P.; Walsh, M.J.; Blackburn, E.A.; Wear, M.A.; Boxer, M.B.; Shen, M.; Veith, H.; McNae, I.W.; Nowicki, M.W.; Michels, P.A.; Auld, D.S.; Fothergill-Gilmore, L.A.; Walkinshaw, M.D.
A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase
Biochem. J.
448
67-72
2012
Leishmania mexicana
Manually annotated by BRENDA team
Zoraghi, R.; See, R.H.; Gong, H.; Lian, T.; Swayze, R.; Finlay, B.B.; Brunham, R.C.; McMaster, W.R.; Reiner, N.E.
Functional analysis, overexpression, and kinetic characterization of pyruvate kinase from methicillin-resistant Staphylococcus aureus
Biochemistry
49
7733-7747
2010
Escherichia coli (A0A0H3JER5), Escherichia coli (P0AD62), Escherichia coli, Staphylococcus aureus (Q6GG09), Staphylococcus aureus, Staphylococcus aureus MRSA252 (Q6GG09)
Manually annotated by BRENDA team
Alontaga, A.Y.; Fenton, A.W.
Effector analogues detect varied allosteric roles for conserved protein-effector interactions in pyruvate kinase isozymes
Biochemistry
50
1934-1939
2011
Homo sapiens
Manually annotated by BRENDA team
Urness, J.M.; Clapp, K.M.; Timmons, J.C.; Bai, X.; Chandrasoma, N.; Buszek, K.R.; Fenton, A.W.
Distinguishing the chemical moiety of phosphoenolpyruvate that contributes to allostery in muscle pyruvate kinase
Biochemistry
52
1-3
2013
Oryctolagus cuniculus
Manually annotated by BRENDA team
Prasannan, C.B.; Villar, M.T.; Artigues, A.; Fenton, A.W.
Identification of regions of rabbit muscle pyruvate kinase important for allosteric regulation by phenylalanine, detected by H/D exchange mass spectrometry
Biochemistry
52
1998-2006
2013
Oryctolagus cuniculus
Manually annotated by BRENDA team
Holyoak, T.; Zhang, B.; Deng, J.; Tang, Q.; Prasannan, C.B.; Fenton, A.W.
Energetic coupling between an oxidizable cysteine and the phosphorylatable N-terminus of human liver pyruvate kinase
Biochemistry
52
466-476
2013
Homo sapiens (P30613), Homo sapiens
Manually annotated by BRENDA team
Diaz-Jullien, C.; Moreira, D.; Sarandeses, C.S.; Covelo, G.; Barbeito, P.; Freire, M.
The M2-type isoenzyme of pyruvate kinase phosphorylates prothymosin alpha in proliferating lymphocytes
Biochim. Biophys. Acta
1814
355-365
2011
Homo sapiens
Manually annotated by BRENDA team
Mazurek, S.
Pyruvate kinase M2: A key enzyme of the tumor metabolome and its medical relevance
Biomed. Res.
23
133-142
2012
Homo sapiens, Mus musculus
-
Manually annotated by BRENDA team
Walsh, M.J.; Brimacombe, K.R.; Veith, H.; Bougie, J.M.; Daniel, T.; Leister, W.; Cantley, L.C.; Israelsen, W.J.; Vander Heiden, M.G.; Shen, M.; Auld, D.S.; Thomas, C.J.; Boxer, M.B.
2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase
Bioorg. Med. Chem. Lett.
21
6322-6327
2011
Homo sapiens
Manually annotated by BRENDA team
Yacovan, A.; Ozeri, R.; Kehat, T.; Mirilashvili, S.; Sherman, D.; Aizikovich, A.; Shitrit, A.; Ben-Zeev, E.; Schutz, N.; Bohana-Kashtan, O.; Konson, A.; Behar, V.; Becker, O.M.
1-(sulfonyl)-5-(arylsulfonyl)indoline as activators of the tumor cell specific M2 isoform of pyruvate kinase
Bioorg. Med. Chem. Lett.
22
6460-6468
2012
Homo sapiens
Manually annotated by BRENDA team
Kumar, N.S.; Amandoron, E.A.; Cherkasov, A.; Finlay, B.B.; Gong, H.; Jackson, L.; Kaur, S.; Lian, T.; Moreau, A.; Labriere, C.; Reiner, N.E.; See, R.H.; Strynadka, N.C.; Thorson, L.; Wong, E.W.; Worrall, L.; Zoraghi, R.; Young, R.N.
Optimization and structure-activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents
Bioorg. Med. Chem.
20
7069-7082
2012
Staphylococcus aureus
Manually annotated by BRENDA team
Chen, J.; Jiang, Z.; Wang, B.; Wang, Y.; Hu, X.
Vitamin K3 and K5 are inhibitors of tumor pyruvate kinase M2
Cancer Lett.
316
204-210
2012
Homo sapiens
Manually annotated by BRENDA team
Gruening, N.M.; Rinnerthaler, M.; Bluemlein, K.; Muelleder, M.; Wamelink, M.M.; Lehrach, H.; Jakobs, C.; Breitenbach, M.; Ralser, M.
Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells
Cell Metab.
14
415-427
2011
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Li, F.; Yu, T.; Zhao, Y.; Yu, S.
Probing the catalytic allosteric mechanism of rabbit muscle pyruvate kinase by tryptophan fluorescence quenching
Eur. Biophys. J.
41
607-614
2012
Oryctolagus cuniculus
Manually annotated by BRENDA team
Ou, Y.; Tao, W.; Zhang, Y.; Wu, G.; Yu, S.
The conformational change of rabbit muscle pyruvate kinase induced by activating cations and its substrates
Int. J. Biol. Macromol.
47
228-232
2010
Oryctolagus cuniculus
Manually annotated by BRENDA team
Morgan, H.P.; McNae, I.W.; Nowicki, M.W.; Hannaert, V.; Michels, P.A.; Fothergill-Gilmore, L.A.; Walkinshaw, M.D.
Allosteric mechanism of pyruvate kinase from Leishmania mexicana uses a rock and lock model
J. Biol. Chem.
285
12892-12898
2010
Leishmania mexicana (Q27686), Leishmania mexicana
Manually annotated by BRENDA team
Mandal, S.; Bose, P.; Dawar, S.; Rajarani, A.; Santha, I.
Kinetic and expression profiling of cytosolic pyruvate kinase enzyme during seed development of Indian mustard (Brassica juncea)
J. Plant Biochem. Biotechnol.
20
102-109
2011
Brassica juncea, Brassica juncea Pusa Bold
-
Manually annotated by BRENDA team
Deng, Y.; Olson, D.G.; Zhou, J.; Herring, C.D.; Joe Shaw, A.; Lynd, L.R.
Redirecting carbon flux through exogenous pyruvate kinase to achieve high ethanol yields in Clostridium thermocellum
Metab. Eng.
15
151-158
2013
no activity in Clostridium thermocellum, Thermoanaerobacterium saccharolyticum
Manually annotated by BRENDA team
Meza, E.; Becker, J.; Bolivar, F.; Gosset, G.; Wittmann, C.
Consequences of phosphoenolpyruvate:sugar phosphotranferase system and pyruvate kinase isozymes inactivation in central carbon metabolism flux distribution in Escherichia coli
Microb. Cell Fact.
11
127
2012
Escherichia coli, Escherichia coli K-12 W3110
Manually annotated by BRENDA team
Chaneton, B.; Hillmann, P.; Zheng, L.; Martin, A.C.; Maddocks, O.D.; Chokkathukalam, A.; Coyle, J.E.; Jankevics, A.; Holding, F.P.; Vousden, K.H.; Frezza, C.; OReilly, M.; Gottlieb, E.
Serine is a natural ligand and allosteric activator of pyruvate kinase M2
Nature
491
458-462
2012
Homo sapiens
Manually annotated by BRENDA team
Benjaphokee, S.; Koedrith, P.; Auesukaree, C.; Asvarak, T.; Sugiyama, M.; Kaneko, Y.; Boonchird, C.; Harashima, S.
CDC19 encoding pyruvate kinase is important for high-temperature tolerance in Saccharomyces cerevisiae
New Biotechnol.
29
166-176
2012
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Bakszt, R.; Wernimont, A.; Allali-Hassani, A.; Mok, M.W.; Hills, T.; Hui, R.; Pizarro, J.C.
The crystal structure of Toxoplasma gondii pyruvate kinase 1
PLoS ONE
5
e12736
2010
Toxoplasma gondii (Q969A2), Toxoplasma gondii
Manually annotated by BRENDA team
Cook, W.J.; Senkovich, O.; Aleem, K.; Chattopadhyay, D.
Crystal structure of Cryptosporidium parvum pyruvate kinase
PLoS ONE
7
e46875
2012
Cryptosporidium parvum (Q5CSM7), Cryptosporidium parvum
Manually annotated by BRENDA team
Ye, J.; Mancuso, A.; Tong, X.; Ward, P.S.; Fan, J.; Rabinowitz, J.D.; Thompson, C.B.
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
Proc. Natl. Acad. Sci. USA
109
6904-6909
2012
Homo sapiens
Manually annotated by BRENDA team
Hofmann, J.; Heider, C.; Li, W.; Krausze, J.; Roessle, M.; Wilharm, G.
Recombinant production of Yersinia enterocolitica pyruvate kinase isoenzymes PykA and PykF
Protein Expr. Purif.
88
243-247
2013
Yersinia enterocolitica, Yersinia enterocolitica WA-314
Manually annotated by BRENDA team
Gupta, V.; Bamezai, R.N.
Human pyruvate kinase M2: a multifunctional protein
Protein Sci.
19
2031-2044
2010
Homo sapiens (P14618), Homo sapiens
Manually annotated by BRENDA team
Solomons, J.T.; Johnsen, U.; Schönheit, P.; Davies, C.
3-Phosphoglycerate is an allosteric activator of pyruvate kinase from the hyperthermophilic archaeon Pyrobaculum aerophilum
Biochemistry
52
5865-5875
2013
Pyrobaculum aerophilum (Q8ZYE0), Pyrobaculum aerophilum, Pyrobaculum aerophilum DSM 7523 (Q8ZYE0)
Manually annotated by BRENDA team
Yu, J.P.; Ladapo, J.; Whitman, W.B.
Pathway of glycogen metabolism in Methanococcus maripaludis
J. Bacteriol.
176
325-332
1994
Methanococcus maripaludis
Manually annotated by BRENDA team
De la Vega-Ruíz, G.; Domínguez-Ramírez, L.; Riveros-Rosas, H.; Guerrero-Mendiola, C.; Torres-Larios, A.; Hernández-Alcántara, G.; García-Trejo, J.J.; Ramírez-Silva, L.
New insights on the mechanism of the K+-independent activity of crenarchaeota pyruvate kinases
PLoS One
10
e0119233
2015
Thermofilum pendens (A1RX09), Thermofilum pendens
Manually annotated by BRENDA team
Haferkamp, P.
Biochemical studies of enzymes involved in glycolysis of the thermoacidophilic crenarchaeon Sulfolobus solfataricus
PH. D. Thesis Universität Duisburg-Essen
2011
0000
2011
Saccharolobus solfataricus (Q97ZD7), Saccharolobus solfataricus DSM 1617 (Q97ZD7)
-
Manually annotated by BRENDA team
van Oirschot, B.A.; Francois, J.J.; van Solinge, W.W.; van Wesel, A.C.; Rijksen, G.; van Amstel, H.K.; van Wijk, R.
Novel type of red blood cell pyruvate kinase hyperactivity predicts a remote regulatory locus involved in PKLR gene expression
Am. J. Hematol.
89
380-384
2014
Homo sapiens
Manually annotated by BRENDA team
Adem, S.; Aslan, A.; Ahmed, I.; Krohn, K.; Guler, C.; Comakl?, V.; Demirdag, R.; Kuzu, M.
Inhibitory and Activating Effects of Some Flavonoid Derivatives on Human Pyruvate Kinase Isoenzyme M2
Arch. Pharm.
349
132-136
2016
Homo sapiens
Manually annotated by BRENDA team
Boehme, C.; Bieber, F.; Linnemann, J.; Breitling, R.; Lorkowski, S.; Reissmann, S.
Chemical and enzymatic characterization of recombinant rabbit muscle pyruvate kinase
Biol. Chem.
394
695-701
2013
Oryctolagus cuniculus
Manually annotated by BRENDA team
Gao, X.; Wang, H.; Yang, J.J.; Chen, J.; Jie, J.; Li, L.; Zhang, Y.; Liu, Z.R.
Reciprocal regulation of protein kinase and pyruvate kinase activities of pyruvate kinase M2 by growth signals
J. Biol. Chem.
288
15971-15979
2013
Homo sapiens
Manually annotated by BRENDA team
Strumilo, S.; Tylicki, A.
Dissimilar properties of pyruvate kinase from rabbit and hare muscle
J. Evol. Biochem. Physiol.
51
117-121
2015
Oryctolagus cuniculus, Lepus europaeus
-
Manually annotated by BRENDA team
Veith, N.; Feldman-Salit, A.; Cojocaru, V.; Henrich, S.; Kummer, U.; Wade, R.C.
Organism-adapted specificity of the allosteric regulation of pyruvate kinase in lactic acid bacteria
PLoS Comput. Biol.
9
e1003159
2013
Enterococcus faecalis, Lactiplantibacillus plantarum, Lactococcus lactis, Streptococcus pyogenes, Streptococcus mutans
Manually annotated by BRENDA team
Auslender, E.L.; Dorion, S.; Dumont, S.; Rivoal, J.
Expression, purification and characterization of Solanum tuberosum recombinant cytosolic pyruvate kinase
Protein Expr. Purif.
110
7-13
2015
Solanum tuberosum
Manually annotated by BRENDA team
He, C.L.; Bian, Y.Y.; Xue, Y.; Liu, Z.X.; Zhou, K.Q.; Yao, C.F.; Lin, Y.; Zou, H.F.; Luo, F.X.; Qu, Y.Y.; Zhao, J.Y.; Ye, M.L.; Zhao, S.M.; Xu, W.
Pyruvate kinase M2 activates mTORC1 by phosphorylating AKT1S1
Sci. Rep.
6
21524
2016
Homo sapiens
Manually annotated by BRENDA team
Kim, S.; Bae, S.J.; Hahn, J.S.
Redirection of pyruvate flux toward desired metabolic pathways through substrate channeling between pyruvate kinase and pyruvate-converting enzymes in Saccharomyces cerevisiae
Sci. Rep.
6
24145
2016
Saccharomyces cerevisiae, Saccharomyces cerevisiae CEN.PK2-1C
Manually annotated by BRENDA team
Chen, Y.L.; Song, J.J.; Chen, X.C.; Xu, W.; Zhi, Q.; Liu, Y.P.; Xu, H.Z.; Pan, J.S.; Ren, J.L.; Guleng, B.
Mechanisms of pyruvate kinase M2 isoform inhibits cell motility in hepatocellular carcinoma cells
World J. Gastroenterol.
21
9093-9102
2015
Homo sapiens
Manually annotated by BRENDA team
Schäfer, T.; Schönheit, P.
Maltose fermentation to acetate, CO2 and H2 in the anaerobic hyperthermophilic archaeon Pyrococcus furiosus evidence for the operation of a novel sugar fermentation pathway
Arch. Microbiol.
158
188-202
1992
Pyrococcus furiosus
-
Manually annotated by BRENDA team
Patil, Y.; Junghare, M.; Müller, N.
Fermentation of glycerol by Anaerobium acetethylicum and its potential use in biofuel production
Microb. Biotechnol.
10
203-217
2017
Anaerobium acetethylicum (A0A1D3TRL9)
Manually annotated by BRENDA team
McFarlane, J.S.; Ronnebaum, T.A.; Meneely, K.M.; Chilton, A.; Fenton, A.W.; Lamb, A.L.
Changes in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation-Pi bond
Acta Crystallogr. Sect. F
75
461-469
2019
Homo sapiens (P30613), Homo sapiens
Manually annotated by BRENDA team
Zhong, W.; Li, K.; Cai, Q.; Guo, J.; Yuan, M.; Wong, Y.H.; Walkinshaw, M.D.; Fothergill-Gilmore, L.A.; Michels, P.A.M.; Dedon, P.C.; Lescar, J.
Pyruvate kinase from Plasmodium falciparum structural and kinetic insights into the allosteric mechanism
Biochem. Biophys. Res. Commun.
532
370-376
2020
Plasmodium falciparum (C6KTA4), Plasmodium falciparum
Manually annotated by BRENDA team
Yan, M.; Chakravarthy, S.; Tokuda, J.M.; Pollack, L.; Bowman, G.D.; Lee, Y.S.
Succinyl-5-aminoimidazole-4-carboxamide-1-ribose 5-phosphate (SAICAR) activates pyruvate kinase isoform M2 (PKM2) in its dimeric form
Biochemistry
55
4731-4736
2016
Homo sapiens (P14618), Homo sapiens
Manually annotated by BRENDA team
Kumari, P.; Idrees, D.; Rath, P.P.; Vijayan, R.; Gourinath, S.
Biochemical and biophysical characterization of the smallest pyruvate kinase from Entamoeba histolytica
Biochim. Biophys. Acta
1868
140296
2020
Entamoeba histolytica (C4LXC4), Entamoeba histolytica
Manually annotated by BRENDA team
Murakami, K.; Yoshino, M.
Zinc inhibition of pyruvate kinase of M-type isozyme
Biometals
30
335-340
2017
Homo sapiens (P14618)
Manually annotated by BRENDA team
Chai, X.; Shang, X.; Zhang, Y.; Liu, S.; Liang, Y.; Zhang, Y.; Wen, T.
A novel pyruvate kinase and its application in lactic acid production under oxygen deprivation in Corynebacterium glutamicum
BMC Biotechnol.
16
79
2016
Corynebacterium glutamicum (Q46078), Corynebacterium glutamicum (Q8NLN1), Corynebacterium glutamicum, Corynebacterium glutamicum LMG 3730 (Q46078), Corynebacterium glutamicum LMG 3730 (Q8NLN1), Corynebacterium glutamicum BCRC 11384 (Q46078), Corynebacterium glutamicum BCRC 11384 (Q8NLN1), Corynebacterium glutamicum ATCC 13032 (Q46078), Corynebacterium glutamicum ATCC 13032 (Q8NLN1), Corynebacterium glutamicum JCM 1318 (Q46078), Corynebacterium glutamicum JCM 1318 (Q8NLN1), Corynebacterium glutamicum NCIMB 10025 (Q46078), Corynebacterium glutamicum NCIMB 10025 (Q8NLN1), Corynebacterium glutamicum DSM 20300 (Q46078), Corynebacterium glutamicum DSM 20300 (Q8NLN1)
Manually annotated by BRENDA team
Labriere, C.; Gong, H.; Finlay, B.B.; Reiner, N.E.; Young, R.N.
Further investigation of inhibitors of MRSA pyruvate kinase towards the conception of novel antimicrobial agents
Eur. J. Med. Chem.
125
1-13
2017
Staphylococcus aureus, Staphylococcus aureus ATCC 29213
Manually annotated by BRENDA team
Ning, X.; Qi, H.; Li, R.; Li, Y.; Jin, Y.; McNutt, M.A.; Liu, J.; Yin, Y.
Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase
Eur. J. Med. Chem.
138
343-352
2017
Homo sapiens (P14618)
Manually annotated by BRENDA team
Li, R.; Ning, X.; Zhou, S.; Lin, Z.; Wu, X.; Chen, H.; Bai, X.; Wang, X.; Ge, Z.; Li, R.; Yin, Y.
Discovery and structure-activity relationship of novel 4-hydroxy-thiazolidine-2-thione derivatives as tumor cell specific pyruvate kinase M2 activators
Eur. J. Med. Chem.
143
48-65
2018
Homo sapiens (P14618), Homo sapiens
Manually annotated by BRENDA team
Gehrig, S.; Macpherson, J.A.; Driscoll, P.C.; Symon, A.; Martin, S.R.; MacRae, J.I.; Kleinjung, J.; Fraternali, F.; Anastasiou, D.
An engineered photoswitchable mammalian pyruvate kinase
FEBS J.
284
2955-2980
2017
Homo sapiens (P14618), Mus musculus (P52480)
Manually annotated by BRENDA team
Krzysciak, W.; Papie?, M.; Jurczak, A.; Koscielniak, D.; Vyhouskaya, P.; Zagorska-Swiezy, K.; Skalniak, A.
Relationship between pyruvate kinase activity and cariogenic biofilm formation in Streptococcus mutans biotypes in caries patients
Front. Microbiol.
8
856
2017
Homo sapiens (P30613), Homo sapiens
Manually annotated by BRENDA team
Gollapali, P.; Chavdi, M.; Sudharshan, S.; Hanumanthappa, M.
Expression, purification, and characterization of pyruvate kinase from Mycobacterium tuberculosis a key allosteric regulatory enzyme
Int. J. Mycobacteriol.
7
368-374
2018
Mycobacterium tuberculosis (P9WKE5), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WKE5), Mycobacterium tuberculosis H37Rv (P9WKE5)
Manually annotated by BRENDA team
Nandi, S.; Dey, M.
Biochemical and structural insights into how amino acids regulate pyruvate kinase muscle isoform 2
J. Biol. Chem.
295
5390-5403
2020
Homo sapiens (A0A024R5Z9), Homo sapiens
Manually annotated by BRENDA team
El-Sayed, M.; Zoraghi, R.; Reiner, N.; Suzen, S.; Ohlsen, K.; Lalk, M.; Altanlar, N.; Hilgeroth, A.
Novel inhibitors of the methicillin-resistant Staphylococcus aureus (MRSA)-pyruvate kinase
J. Enzyme Inhib. Med. Chem.
31
1666-1671
2016
Staphylococcus aureus, Staphylococcus aureus ATCC 43300
Manually annotated by BRENDA team
Ning, X.; Qi, H.; Li, R.; Jin, Y.; McNutt, M.A.; Yin, Y.
Synthesis and antitumor activity of novel 2,3-didithiocarbamate substituted naphthoquinones as inhibitors of pyruvate kinase M2 isoform
J. Enzyme Inhib. Med. Chem.
33
126-129
2018
Homo sapiens (P14618)
Manually annotated by BRENDA team
Pinto Torres, J.E.; Yuan, M.; Goossens, J.; Versees, W.; Caljon, G.; Michels, P.A.; Walkinshaw, M.D.; Magez, S.; Sterckx, Y.G.
Structural and kinetic characterization of Trypanosoma congolense pyruvate kinase
Mol. Biochem. Parasitol.
236
111263
2020
Trypanosoma congolense (G0UYF4), Trypanosoma congolense, Trypanosoma brucei brucei (P30615), Trypanosoma congolense IL3000 (G0UYF4)
Manually annotated by BRENDA team
Kumar, S.; Patel, A.K.
Purification and characterization of prolyl hydroxylase 3/pyruvate kinase isoform 2 protein complex
Mol. Biotechnol.
62
111-118
2020
Homo sapiens (P14618)
Manually annotated by BRENDA team
Bell, R.A.V.; Storey, K.B.
Purification and characterization of skeletal muscle pyruvate kinase from the hibernating ground squirrel, Urocitellus richardsonii potential regulation by posttranslational modification during torpor
Mol. Cell. Biochem.
442
47-58
2018
Urocitellus richardsonii
Manually annotated by BRENDA team
Matsuda, S.; Adachi, J.; Ihara, M.; Tanuma, N.; Shima, H.; Kakizuka, A.; Ikura, M.; Ikura, T.; Matsuda, T.
Nuclear pyruvate kinase M2 complex serves as a transcriptional coactivator of arylhydrocarbon receptor
Nucleic Acids Res.
44
636-647
2016
Homo sapiens (P14618)
Manually annotated by BRENDA team
Mattice, A.M.S.; MacLean, I.A.; Childers, C.L.; Storey, K.B.
Characterization of pyruvate kinase from the anoxia tolerant turtle, Trachemys scripta elegans a potential role for enzyme methylation during metabolic rate depression
PeerJ
6
e4918
2018
Trachemys scripta elegans (Q9I8C5), Trachemys scripta elegans (Q9PU23), Trachemys scripta elegans
Manually annotated by BRENDA team
Wulfert, S.; Schilasky, S.; Krueger, S.
Transcriptional and biochemical characterization of cytosolic pyruvate kinases in Arabidopsis thaliana
Plants (Basel)
9
353
2020
Arabidopsis thaliana (Q94KE3), Arabidopsis thaliana (Q9FFP6), Arabidopsis thaliana (Q9FM97), Arabidopsis thaliana (Q9FNN1), Arabidopsis thaliana (Q9SJQ0), Arabidopsis thaliana
Manually annotated by BRENDA team
Guerrero-Mendiola, C.; Garcia-Trejo, J.J.; Encalada, R.; Saavedra, E.; Ramirez-Silva, L.
The contribution of two isozymes to the pyruvate kinase activity of Vibrio cholerae one K+-dependent constitutively active and another K+-independent with essential allosteric activation
PLoS ONE
12
e0178673
2017
Vibrio cholerae serotype O1 (Q9KQJ0), Vibrio cholerae serotype O1 (Q9KUN0), Vibrio cholerae serotype O1 El Tor Inaba N16961 (Q9KQJ0), Vibrio cholerae serotype O1 El Tor Inaba N16961 (Q9KUN0), Vibrio cholerae serotype O1 ATCC 39315 (Q9KQJ0), Vibrio cholerae serotype O1 ATCC 39315 (Q9KUN0)
Manually annotated by BRENDA team
Verma, K.; Patel, A.
Pyruvate kinase M2 serves as blockade for nucleosome repositioning and abrogates Chd7 remodeling activity
PLoS ONE
14
e0211515
2019
Homo sapiens (P14618)
Manually annotated by BRENDA team