Reference on EC 2.7.1.33 - pantothenate kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Brown, G.M.
The metabolism of pantothenic acid
J. Biol. Chem.
234
370-378
1959
Saccharomyces cerevisiae, Escherichia coli, Lactiplantibacillus plantarum, Morganella morganii, no activity in Lactobacillus helveticus, no activity in Neurospora crassa, Rattus norvegicus
Nishimura, N.; Kakimoto, T.; Chibata, I.
Mechanism of coenzyme A biosynthesis by Sarcina lutea
J. Ferment. Technol.
61
95-99
1983
Micrococcus luteus
-
Abiko, Y.; Ashida, S.I.; Shimizu, M.
Purification and properties of D-pantothenate kinase from rat liver
Biochim. Biophys. Acta
268
364-372
1972
Rattus norvegicus
Falk, K.L.; Guerra, D.J.
Coenzyme A biosynthesis in plants: partial purification and characterization of pantothenate kinase from spinach
Arch. Biochem. Biophys.
301
424-430
1993
Brassica napus, Spinacia oleracea
Shimizu, S.; Kubo, K.; Tani, Y.; Ogata, K.
Purification and properties of pantothenate kinase from brevibacterium ammoniagenes IFO 12071
Agric. Biol. Chem.
37
2863-2870
1973
Corynebacterium ammoniagenes
-
Halvorsen, O.; Skrede, S.
Regulation of the biosynthesis of CoA at the level of pantothenate kinase
Eur. J. Biochem.
124
211-215
1982
Rattus norvegicus
Fisher, M.N.; Robishaw, J.D.; Neely, J.R.
The properties and regulation of pantothenate kinase from rat heart
J. Biol. Chem.
260
15745-15751
1985
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Fisher, M.N.; Neely, J.R.
Regulation of pantothenate kinase from various tissues of the rat
FEBS Lett.
190
293-296
1985
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Vallari, D.S.; Jackowski, S.; Rock, C.O.
Regulation of pantothenate kinase by coenzyme A and its thioesters
J. Biol. Chem.
262
2468-2471
1987
Escherichia coli
Halvorsen, O.; Tverdal, S.
Multiple molecular forms of rat liver pantothenate kinase
Scand. J. Clin. Lab. Invest.
46
67-70
1986
Rattus norvegicus
-
Yun, M.; Park, C.G.; Kim, J.Y.; Rock, C.O.; Jackowski, S.; Park, H.W.
Structural basis for the feedback regulation of Escherichia coli pantothenate kinase by coenzyme A
J. Biol. Chem.
275
28093-28099
2000
Escherichia coli
Rock, C.O.; Calder, R.B.; Karim, M.A.; Jackowski, S.
Pantothenate kinase regulation of the intracellular concentration of coenzyme A
J. Biol. Chem.
275
1377-1383
2000
Mus musculus (Q8K4K6), Mus musculus
Choudhry, A.E.; Mandichak, T.L.; Broskey, J.P.; Egolf, R.W.; Kinsland, C.; Begley, T.P.; Seefeld, M.A.; Ku, T.W.; Brown, J.R.; Zalacain, M.; Ratnam, K.
Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections
Antimicrob. Agents Chemother.
47
2051-2055
2003
Staphylococcus aureus
Rock, C.O.; Park, H.W.; Jackowski, S.
Role of feedback regulation of pantothenate kinase (CoaA) in control of coenzyme A levels in Escherichia coli
J. Bacteriol.
185
3410-3415
2003
Escherichia coli (P0A6I3), Escherichia coli
Rock, C.O.; Karim, M.A.; Zhang, Y.M.; Jackowski, S.
The murine pantothenate kinase (Pank1) gene encodes two differentially regulated pantothenate kinase isozymes
Gene
291
35-43
2002
Mus musculus (Q8K4K6), Mus musculus
Afshar, K.; Gonczy, P.; DiNardo, S.; Wasserman, S.A.
Fumble encodes a pantothenate kinase homolog required for proper mitosis and meiosis in Drosophila melanogaster
Genetics
157
1267-1276
2001
Drosophila melanogaster
Calder, R.B.; Williams, R.S.; Ramaswamy, G.; Rock, C.O.; Campbell, E.; Unkles, S.E.; Kinghorn, J.R.; Jackowski, S.
Cloning and characterization of a eukaryotic pantothenate kinase gene (panK) from Aspergillus nidulans
J. Biol. Chem.
274
2014-2020
1999
Aspergillus nidulans (O93921), Aspergillus nidulans
Das, S.; Kumar, P.; Bhor, V.; Surolia, A.; Vijayan, M.
Expression, purification, crystallization and preliminary X-ray crystallographic analysis of pantothenate kinase from Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
F61
65-67
2005
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Johnson, M.A.; Kuo, Y.M.; Westaway, S.K.; Parker, S.M.; Ching, K.H.; Gitschier, J.; Hayflick, S.J.
Mitochondrial localization of human PANK2 and hypotheses of secondary iron accumulation in pantothenate kinase-associated neurodegeneration
Ann. N. Y. Acad. Sci.
1012
282-298
2004
Homo sapiens (Q9BZ23), Homo sapiens
Spry, C.; Chai, C.L.; Kirk, K.; Saliba, K.J.
A class of pantothenic acid analogs inhibits Plasmodium falciparum pantothenate kinase and represses the proliferation of malaria parasites
Antimicrob. Agents Chemother.
49
4649-4657
2005
Homo sapiens, Plasmodium falciparum
Virga, K.G.; Zhang, Y.M.; Leonardi, R.; Ivey, R.A.; Hevener, K.; Park, H.W.; Jackowski, S.; Rock, C.O.; Lee, R.E.
Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors
Bioorg. Med. Chem.
14
1007-1020
2006
Aspergillus nidulans, Escherichia coli, Staphylococcus aureus, Mus musculus
Ivey, R.A.; Zhang, Y.M.; Virga, K.G.; Hevener, K.; Lee, R.E.; Rock, C.O.; Jackowski, S.; Park, H.W.
The structure of the pantothenate kinase-ADP-pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites
J. Biol. Chem.
279
35622-35629
2004
Escherichia coli (P0A6I3), Escherichia coli
Brand, L.A.; Strauss, E.
Characterization of a new pantothenate kinase isoform from Helicobacter pylori
J. Biol. Chem.
280
20185-20188
2005
Bacillus subtilis, Helicobacter pylori (p37564), Helicobacter pylori
Zhang, Y.M.; Rock, C.O.; Jackowski, S.
Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters
J. Biol. Chem.
280
32594-32601
2005
Mus musculus
Leonardi, R.; Chohnan, S.; Zhang, Y.M.; Virga, K.G.; Lee, R.E.; Rock, C.O.; Jackowski, S.
A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A
J. Biol. Chem.
280
3314-3322
2005
Staphylococcus aureus, Staphylococcus aureus RN4220
Zhang, Y.M.; Rock, C.O.; Jackowski, S.
Biochemical properties of human pantothenate kinase 2 isoforms and mutations linked to pantothenate kinase-associated neurodegeneration
J. Biol. Chem.
281
107-114
2006
Homo sapiens
Kotzbauer, P.T.; Truax, A.C.; Trojanowski, J.Q.; Lee, V.M.
Altered neuronal mitochondrial coenzyme A synthesis in neurodegeneration with brain iron accumulation caused by abnormal processing, stability, and catalytic activity of mutant pantothenate kinase 2
J. Neurosci.
25
689-698
2005
Homo sapiens
Das, S.; Kumar, P.; Bhor, V.; Surolia, A.; Vijayan, M.
Invariance and variability in bacterial PanK: a study based on the crystal structure of Mycobacterium tuberculosis PanK
Acta Crystallogr. Sect. D
62
628-638
2006
Escherichia coli (P0A6I3), Escherichia coli, Mycobacterium tuberculosis (P9WPA7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPA7)
Hartig, M.B.; Hoertnagel, K.; Garavaglia, B.; Zorzi, G.; Kmiec, T.; Klopstock, T.; Rostasy, K.; Svetel, M.; Kostic, V.S.; Schuelke, M.; Botz, E.; Weindl, A.; Novakovic, I.; Nardocci, N.; Prokisch, H.; Meitinger, T.
Genotypic and phenotypic spectrum of PANK2 mutations in patients with neurodegeneration with brain iron accumulation
Ann. Neurol.
59
248-256
2006
Homo sapiens (Q9BZ23), Homo sapiens
Chen, X.; Shen, D.; Zhou, B.
Analysis of the temperature-sensitive mutation of Escherichia coli pantothenate kinase reveals YbjN as a possible protein stabilizer
Biochem. Biophys. Res. Commun.
345
834-842
2006
Escherichia coli
Nicely, N.I.; Parsonage, D.; Paige, C.; Newton, G.L.; Fahey, R.C.; Leonardi, R.; Jackowski, S.; Mallett, T.C.; Claiborne, A.
Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: implications for coenzyme A-dependent redox biology
Biochemistry
46
3234-3245
2007
Bacillus anthracis, Bacillus anthracis (Q81VX4)
Zhang, Y.M.; Chohnan, S.; Virga, K.G.; Stevens, R.D.; Ilkayeva, O.R.; Wenner, B.R.; Bain, J.R.; Newgard, C.B.; Lee, R.E.; Rock, C.O.; Jackowski, S.
Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis
Chem. Biol.
14
291-302
2007
Mus musculus
Yang, K.; Eyobo, Y.; Brand, L.A.; Martynowski, D.; Tomchick, D.; Strauss, E.; Zhang, H.
Crystal structure of a type III pantothenate kinase: insight into the mechanism of an essential coenzyme A biosynthetic enzyme universally distributed in bacteria
J. Bacteriol.
188
5532-5540
2006
Thermotoga maritima
Lehane, A.M.; Marchetti, R.V.; Spry, C.; van Schalkwyk, D.A.; Teng, R.; Kirk, K.; Saliba, K.J.
Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite
J. Biol. Chem.
282
25395-25405
2007
Plasmodium falciparum
Li, Y.; Chang, Y.; Zhang, L.; Feng, Q.; Liu, Z.; Zhang, Y.; Zuo, J.; Meng, Y.; Fang, F.
High glucose upregulates pantothenate kinase 4 (PanK4) and thus affects M2-type pyruvate kinase (Pkm2)
Mol. Cell. Biochem.
277
117-125
2005
Rattus norvegicus (Q923S8), Rattus norvegicus
Tilton, G.B.; Wedemeyer, W.J.; Browse, J.; Ohlrogge, J.
Plant coenzyme A biosynthesis: characterization of two pantothenate kinases from Arabidopsis
Plant Mol. Biol.
61
629-642
2006
Arabidopsis thaliana
Leonardi, R.; Rock, C.O.; Jackowski, S.; Zhang, Y.M.
Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine
Proc. Natl. Acad. Sci. USA
104
1494-1499
2007
Homo sapiens, Homo sapiens (Q9BZ23)
Hong, B.S.; Yun, M.K.; Zhang, Y.M.; Chohnan, S.; Rock, C.O.; White, S.W.; Jackowski, S.; Park, H.W.; Leonardi, R.
Prokaryotic type II and type III pantothenate kinases: The same monomer fold creates dimers with distinct catalytic properties
Structure
14
1251-1261
2006
Staphylococcus aureus (Q6G7I0), Pseudomonas aeruginosa (Q9HWC1)
Kumar, P.; Chhibber, M.; Surolia, A.
How pantothenol intervenes in coenzyme-A biosynthesis of Mycobacterium tuberculosis
Biochem. Biophys. Res. Commun.
361
903-909
2007
Mycobacterium tuberculosis (P9WPA7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPA7)
Clement, F.; Devos, D.; Moreau, C.; Coubes, P.; Destee, A.; Defebvre, L.
Neurodegeneration with brain iron accumulation: clinical, radiographic and genetic heterogeneity and corresponding therapeutic options
Acta Neurol. Belg.
107
26-31
2007
Homo sapiens
Isaac, C.; Wright, I.; Bhattacharyya, D.; Baxter, P.; Rowe, J.
Pallidal stimulation for pantothenate kinase-associated neurodegeneration dystonia
Arch. Dis. Child.
93
239-240
2008
Homo sapiens
Yang, K.; Strauss, E.; Huerta, C.; Zhang, H.
Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase
Biochemistry
47
1369-1380
2008
Helicobacter pylori, Thermotoga maritima (Q9WZY5), Thermotoga maritima
Mikati, M.A.; Yehya, A.; Darwish, H.; Karam, P.; Comair, Y.
Deep brain stimulation as a mode of treatment of early onset pantothenate kinase-associated neurodegeneration
Eur. J. Paediatr. Neurol.
13
61-64
2008
Homo sapiens
Leonardi, R.; Zhang, Y.M.; Lykidis, A.; Rock, C.O.; Jackowski, S.
Localization and regulation of mouse pantothenate kinase 2
FEBS Lett.
581
4639-4644
2007
Homo sapiens, Mus musculus
Spry, C.; Kirk, K.; Saliba, K.J.
Coenzyme A biosynthesis: an antimicrobial drug target
FEMS Microbiol. Rev.
32
56-106
2008
Escherichia coli, Staphylococcus aureus, Mycobacterium tuberculosis
Chan, K.Y.; Lam, C.W.; Lee, L.P.; Tong, S.F.; Yuen, Y.P.
Pantothenate kinase-associated neurodegeneration in two Chinese children: identification of a novel PANK2 gene mutation
Hong Kong Med. J.
14
70-73
2008
Homo sapiens
Bosveld, F.; Rana, A.; van der Wouden, P.E.; Lemstra, W.; Ritsema, M.; Kampinga, H.H.; Sibon, O.C.
De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system
Hum. Mol. Genet.
17
2058-2069
2008
Drosophila sp. (in: flies)
Paige, C.; Reid, S.D.; Hanna, P.C.; Claiborne, A.
The type III pantothenate kinase encoded by coaX is essential for growth of Bacillus anthracis
J. Bacteriol.
190
6271-6275
2008
Bacillus anthracis
Hong, B.S.; Senisterra, G.; Rabeh, W.M.; Vedadi, M.; Leonardi, R.; Zhang, Y.M.; Rock, C.O.; Jackowski, S.; Park, H.W.
Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder
J. Biol. Chem.
282
27984-27993
2007
Homo sapiens (Q8TE04), Homo sapiens (Q9H999), Homo sapiens
Kazek, B.; Jamroz, E.; Gencik, M.; Jezela Stanek, A.; Marszal, E.; Wojaczynska-Stanek, K.
A novel PANK2 gene mutation: clinical and molecular characteristics of patients short communication
J. Child Neurol.
22
1256-1259
2007
Homo sapiens
Ellers, J.; Marien, J.; Driessen, G.; van Straalen, N.M.
Temperature-induced gene expression associated with different thermal reaction norms for growth rate
J. Exp. Zool. B Mol. Dev. Evol.
310
137-147
2008
Orchesella cincta
Kuo, Y.M.; Hayflick, S.J.; Gitschier, J.
Deprivation of pantothenic acid elicits a movement disorder and azoospermia in a mouse model of pantothenate kinase-associated neurodegeneration
J. Inherit. Metab. Dis.
30
310-317
2007
Mus musculus
Freeman, K.; Gregory, A.; Turner, A.; Blasco, P.; Hogarth, P.; Hayflick, S.
Intellectual and adaptive behaviour functioning in pantothenate kinase-associated neurodegeneration
J. Intellect. Disabil. Res.
51
417-426
2007
Homo sapiens
Wilfred, B.R.; Wang, W.X.; Nelson, P.T.
Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways
Mol. Genet. Metab.
91
209-217
2007
Homo sapiens
Lyoo, C.H.; Prokisch, H.; Meitinger, T.; Lee, S.Y.; Kim, d.o..H.; Lee, M.S.
Anticholinergic-responsive gait freezing in a patient with pantothenate kinase-associated neurodegeneration
Mov. Disord.
23
283-284
2008
Homo sapiens
Schneider, S.A.; Walker, R.H.; Bhatia, K.P.
The Huntingtons disease-like syndromes: what to consider in patients with a negative Huntingtons disease gene test
Nat. Clin. Pract. Neurol.
3
517-525
2007
Homo sapiens, Homo sapiens (Q9BZ23)
McNeill, A.; Birchall, D.; Hayflick, S.J.; Gregory, A.; Schenk, J.F.; Zimmerman, E.A.; Shang, H.; Miyajima, H.; Chinnery, P.F.
T2* and FSE MRI distinguishes four subtypes of neurodegeneration with brain iron accumulation
Neurology
70
1614-1619
2008
Homo sapiens
Saleheen, D.; Ali, T.; Aly, Z.; Khealani, B.; Frossard, P.M.
Novel mutation in the PANK2 gene leads to pantothenate kinase-associated neurodegeneration in a Pakistani family
Pediatr. Neurol.
37
296-298
2007
Homo sapiens
Shields, D.C.; Sharma, N.; Gale, J.T.; Eskandar, E.N.
Pallidal stimulation for dystonia in pantothenate kinase-associated neurodegeneration
Pediatr. Neurol.
37
442-445
2007
Homo sapiens
Wong, R.W.; Richa, D.C.; Hahn, P.; Green, W.R.; Dunaief, J.L.
Iron toxicity as a potential factor in AMD
Retina (Philadelphia, Pa. )
27
997-1003
2007
Homo sapiens
Marquez, M.; Serafin, A.; Fernandez-Bellon, H.; Serrat, S.; Ferrer-Admetlla, A.; Bertranpetit, J.; Ferrer, I.; Pumarola, M.
Neuropathologic findings in an aged albino gorilla
Vet. Pathol.
45
531-537
2008
Gorilla beringei
Chetnani, B.; Das, S.; Kumar, P.; Surolia, A.; Vijayan, M.
Mycobacterium tuberculosis pantothenate kinase: possible changes in location of ligands during enzyme action
Acta Crystallogr. Sect. D
65
312-325
2009
Escherichia coli, Mycobacterium tuberculosis (P9WPA7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPA7)
Yao, J.; Patrone, J.D.; Dotson, G.D.
Characterization and kinetics of phosphopantothenoylcysteine synthetase from Enterococcus faecalis
Biochemistry
48
2799-2806
2009
Enterococcus faecalis (Q839J7)
Olzhausen, J.; Schuebbe, S.; Schueller, H.J.
Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1
Curr. Genet.
55
163-173
2009
Saccharomyces cerevisiae
Wu, Z.; Li, C.; Lv, S.; Zhou, B.
Pantothenate kinase-associated neurodegeneration: insights from a Drosophila model
Hum. Mol. Genet.
18
3659-3672
2009
Drosophila melanogaster, Homo sapiens (Q9BZ23), Homo sapiens
Takagi, M.; Tamaki, H.; Miyamoto, Y.; Leonardi, R.; Hanada, S.; Jackowski, S.; Chohnan, S.
Pantothenate kinase from the thermoacidophilic archaeon Picrophilus torridus
J. Bacteriol.
192
233-241
2010
Picrophilus torridus (Q6L2I5), Picrophilus torridus
Doi, H.; Koyano, S.; Miyatake, S.; Matsumoto, N.; Kameda, T.; Tomita, A.; Miyaji, Y.; Suzuki, Y.; Sawaishi, Y.; Kuroiwa, Y.
Siblings with the adult-onset slowly progressive type of pantothenate kinase-associated neurodegeneration and a novel mutation, Ile346Ser, in PANK2: Clinical features and (99m)Tc-ECD brain perfusion SPECT findings
J. Neurol. Sci.
290
172-176
2009
Homo sapiens
Rowan, A.S.; Nicely, N.I.; Cochrane, N.; Wlassoff, W.A.; Claiborne, A.; Hamilton, C.J.
Nucleoside triphosphate mimicry: a sugar triazolyl nucleoside as an ATP-competitive inhibitor of B. anthracis pantothenate kinase
Org. Biomol. Chem.
7
4029-4036
2009
Bacillus anthracis
Chetnani, B.; Kumar, P.; Abhinav, K.V.; Chhibber, M.; Surolia, A.; Vijayan, M.
Location and conformation of pantothenate and its derivatives in Mycobacterium tuberculosis pantothenate kinase: insights into enzyme action
Acta Crystallogr. Sect. D
67
774-783
2011
Mycobacterium tuberculosis (P9WPA7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPA7)
Leonardi, R.; Zhang, Y.M.; Yun, M.K.; Zhou, R.; Zeng, F.Y.; Lin, W.; Cui, J.; Chen, T.; Rock, C.O.; White, S.W.; Jackowski, S.
Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain
Chem. Biol.
17
892-902
2010
Homo sapiens, Homo sapiens (Q9H999)
Gutierrez, L.; Sabaratnam, N.; Aktar, R.; Bettedi, L.; Mandilaras, K.; Missirlis, F.
Zinc accumulation in heterozygous mutants of fumble, the pantothenate kinase homologue of Drosophila
FEBS Lett.
584
2942-2946
2010
Drosophila melanogaster
Venkatraman, J.; Bhat, J.; Solapure, S.M.; Sandesh, J.; Sarkar, D.; Aishwarya, S.; Mukherjee, K.; Datta, S.; Malolanarasimhan, K.; Bandodkar, B.; Das, K.S.
Screening, identification, and characterization of mechanistically diverse inhibitors of the Mycobacterium tuberculosis enzyme, pantothenate kinase (CoaA)
J. Biomol. Screen.
17
293-302
2012
Mycobacterium tuberculosis
Mandakh, A.; Niraula, N.P.; Kim, E.P.; Sohng, J.K.
Identification and characterization of a pantothenate kinase (PanK-sp) from Streptomyces peucetius ATCC 27952
J. Microbiol. Biotechnol.
20
1689-1695
2010
Streptomyces peucetius (D2K764), Streptomyces peucetius, Streptomyces peucetius ATCC 27952 (D2K764)
Chetnani, B.; Kumar, P.; Surolia, A.; Vijayan, M.
M. tuberculosis pantothenate kinase: dual substrate specificity and unusual changes in ligand locations
J. Mol. Biol.
400
171-185
2010
Mycobacterium tuberculosis
Awasthy, D.; Ambady, A.; Bhat, J.; Sheikh, G.; Ravishankar, S.; Subbulakshmi, V.; Mukherjee, K.; Sambandamurthy, V.; Sharma, U.
Essentiality and functional analysis of type I and type III pantothenate kinases of Mycobacterium tuberculosis
Microbiology
156
2691-2701
2010
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (ATCC 27294)
Leonardi, R.; Rehg, J.E.; Rock, C.O.; Jackowski, S.
Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state
PLoS ONE
5
e11107
2010
Mus musculus
Ishibashi, T.; Tomita, H.; Yokooji, Y.; Morikita, T.; Watanabe, B.; Hiratake, J.; Kishimoto, A.; Kita, A.; Miki, K.; Imanaka, T.; Atomi, H.
A detailed biochemical characterization of phosphopantothenate synthetase, a novel enzyme involved in coenzyme A biosynthesis in the Archaea
Extremophiles
16
819-828
2012
Thermococcus kodakarensis (Q5JHF1), Thermococcus kodakarensis
Awuah, E.; Ma, E.; Hoegl, A.; Vong, K.; Habib, E.; Auclair, K.
Exploring structural motifs necessary for substrate binding in the active site of Escherichia coli pantothenate kinase
Bioorg. Med. Chem.
22
3083-3090
2014
Escherichia coli (P0A6I3), Escherichia coli
Ogata, Y.; Katoh, H.; Asayama, M.; Chohnan, S.
Role of prokaryotic type I and III pantothenate kinases in the coenzyme A biosynthetic pathway of Bacillus subtilis
Can. J. Microbiol.
60
297-305
2014
Bacillus subtilis
Bjoerkelid, C.; Bergfors, T.; Raichurkar, A.K.; Mukherjee, K.; Malolanarasimhan, K.; Bandodkar, B.; Jones, T.A.
Structural and biochemical characterization of compounds inhibiting Mycobacterium tuberculosis pantothenate kinase
J. Biol. Chem.
288
18260-18270
2013
Mycobacterium tuberculosis (P9WPA7), Mycobacterium tuberculosis
Ogata, Y.; Chohnan, S.
Prokaryotic type III pantothenate kinase enhances coenzyme A biosynthesis in Escherichia coli
J. Gen. Appl. Microbiol.
61
266-269
2016
Escherichia coli
Li, B.; Tempel, W.; Smil, D.; Bolshan, Y.; Schapira, M.; Park, H.W.
Crystal structures of Klebsiella pneumoniae pantothenate kinase in complex with N-substituted pantothenamides
Proteins
81
1466-1472
2013
Klebsiella pneumoniae (B5XYG3), Klebsiella pneumoniae, Klebsiella pneumoniae 342 (B5XYG3)
Hughes, S.J.; Antoshchenko, T.; Kim, K.P.; Smil, D.; Park, H.W.
Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumoniae and Staphylococcus aureus
Proteins
82
1542-1548
2014
Klebsiella pneumoniae (B5XYG3), Klebsiella pneumoniae, Staphylococcus aureus (Q6G7I0), Staphylococcus aureus, Staphylococcus aureus MSSA476 (Q6G7I0), Klebsiella pneumoniae 342 (B5XYG3)
Hughes, S.J.; Barnard, L.; Mottaghi, K.; Tempel, W.; Antoshchenko, T.; Hong, B.S.; Allali-Hassani, A.; Smil, D.; Vedadi, M.; Strauss, E.; Park, H.W.
Discovery of potent pantothenamide inhibitors of Staphylococcus aureus pantothenate kinase through a minimal SAR study inhibition is due to trapping of the product
ACS Infect. Dis.
2
627-641
2016
Staphylococcus aureus (A0A167Z3Z6), Staphylococcus aureus, Staphylococcus aureus RN4220 (A0A167Z3Z6)
Paul, A.; Kumar, P.; Surolia, A.; Vijayan, M.
Biochemical and structural studies of mutants indicate concerted movement of the dimer interface and ligand-binding region of Mycobacterium tuberculosis pantothenate kinase
Acta Crystallogr. Sect. F
73
635-643
2017
Mycobacterium tuberculosis (P9WPA1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPA1), Mycobacterium tuberculosis ATCC 25618 (P9WPA1)
Liu, W.; Zhang, B.; Jiang, R.
Improving acetyl-CoA biosynthesis in Saccharomyces cerevisiae via the overexpression of pantothenate kinase and PDH bypass
Biotechnol. Biofuels
10
41
2017
Saccharomyces cerevisiae (Q04430), Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4742 (Q04430), Saccharomyces cerevisiae ATCC 204508 (Q04430)
Satoh, S.; Ozaki, M.; Matsumoto, S.; Nabatame, T.; Kaku, M.; Shudo, T.; Asayama, M.; Chohnan, S.
Enhancement of fatty acid biosynthesis by exogenous acetyl-CoA carboxylase and pantothenate kinase in Escherichia coli
Biotechnol. Lett.
42
2595-2605
2020
Pseudomonas putida (V5XWU6)
Spry, C.; Sewell, A.L.; Hering, Y.; Villa, M.V.J.; Weber, J.; Hobson, S.J.; Harnor, S.J.; Gul, S.; Marquez, R.; Saliba, K.J.
Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation
Eur. J. Med. Chem.
143
1139-1147
2018
Plasmodium falciparum (Q8ILP4), Plasmodium falciparum
Nurkanto, A.; Jeelani, G.; Yamamoto, T.; Naito, Y.; Hishiki, T.; Mori, M.; Suematsu, M.; Shiomi, K.; Hashimoto, T.; Nozaki, T.
Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target
Int. J. Parasitol. Drugs Drug Resist.
8
125-136
2018
Entamoeba histolytica (B1N2P3), Entamoeba histolytica
Subramanian, C.; Yun, M.K.; Yao, J.; Sharma, L.K.; Lee, R.E.; White, S.W.; Jackowski, S.; Rock, C.O.
Allosteric regulation of mammalian pantothenate kinase
J. Biol. Chem.
291
22302-22314
2016
Mus musculus, Mus musculus (Q8K4K6), Mus musculus (Q8R2W9), Homo sapiens (Q8TE04), Homo sapiens (Q9BZ23), Homo sapiens (Q9H999), Homo sapiens
Chiu, J.E.; Thekkiniath, J.; Mehta, S.; Mueller, C.; Bracher, F.; Ben Mamoun, C.
The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors
J. Biol. Chem.
294
14757-14767
2019
Saccharomyces cerevisiae (Q04430), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (Q04430)
Tjhin, E.T.; Spry, C.; Sewell, A.L.; Hoegl, A.; Barnard, L.; Sexton, A.E.; Siddiqui, G.; Howieson, V.M.; Maier, A.G.; Creek, D.J.; Strauss, E.; Marquez, R.; Auclair, K.; Saliba, K.J.
Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues
PLoS Pathog.
14
e1006918
2018
Plasmodium falciparum (Q8ILP4), Plasmodium falciparum
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