Information on EC 2.7.1.33 - pantothenate kinase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY hide
2.7.1.33
-
RECOMMENDED NAME
GeneOntology No.
pantothenate kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Metabolic pathways
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Pantothenate and CoA biosynthesis
-
-
phosphopantothenate biosynthesis I
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phosphopantothenate biosynthesis II
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superpathway of coenzyme A biosynthesis III (mammals)
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coenzyme A metabolism
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SYSTEMATIC NAME
IUBMB Comments
ATP:(R)-pantothenate 4'-phosphotransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9026-48-6
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
ecotype Colombia-0
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
-
-
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Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
no activity in Lactobacillus helveticus
-
-
-
Manually annotated by BRENDA team
no activity in Neurospora crassa
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
Sprague-Dawley
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-
Manually annotated by BRENDA team
spinach
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Manually annotated by BRENDA team
strain RN4220, gene coaA
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-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
pantothenate kinase catalyzes the rate-controlling step in coenzyme A biosynthesis; pantothenate kinase catalyzes the rate-controlling step in coenzyme A biosynthesis
physiological function
additional information
-
mitochondria-targeted human pantothenate kinase-2 is involved in pantothenate kinase-associated neurodegeneration
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[(piperidin-4-yl)methyl]amino]propyl)butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-[[(piperidin-4-yl)methyl]amino]propyl)amino]butyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(piperazin-1-yl)ethyl]amino]propyl)butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-[[2-(piperazin-1-yl)ethyl]amino]propyl)amino]butyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(pyridin-2-yl)ethyl]amino]propyl)butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-[[2-(pyridin-2-yl)ethyl]amino]propyl)amino]butyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[2-oxo-2-(pentylamino)ethyl]amino]propyl)butanamide
ADP + N2-(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propyl)-N-pentylglycinamide
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[3-(morpholin-4-yl)propyl]amino]-3-oxopropyl)butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-[(3-[[3-(morpholin-4-yl)propyl]amino]-3-oxopropyl)amino]-4-oxobutyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[(1-pentyl-1H-1,2,3-triazol-4-yl)methyl]butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[(1-pentyl-1H-1,2,3-triazol-4-yl)methyl]amino]butyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-(1-propyl-1H-1,2,3-triazol-4-yl)propyl]butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-(1-propyl-1H-1,2,3-triazol-4-yl)propyl]amino]butyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pentylamino)propyl]butanamide
ADP + N3-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-pentyl-beta-alaninamide
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(phenylamino)propyl]butanamide
ADP + N3-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-phenyl-beta-alaninamide
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pyrimidin-4-ylamino)propyl]butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-([3-oxo-3-[(pyrimidin-4-yl)amino]propyl]amino)butyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(3-phenylpropyl)amino]propyl]butanamide
ADP + N3-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(3-phenylpropyl)-beta-alaninamide
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-2-ylmethyl)amino]propyl]butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-[[(pyridin-2-yl)methyl]amino]propyl)amino]butyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-3-ylmethyl)amino]propyl]butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-[[(pyridin-3-yl)methyl]amino]propyl)amino]butyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-4-ylmethyl)amino]propyl]butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-[[(pyridin-4-yl)methyl]amino]propyl)amino]butyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-[(3-methylpyridin-2-yl)amino]-3-oxopropyl]butanamide
ADP + (3R)-4-([3-[(3-aminopyridin-2-yl)amino]-3-oxopropyl]amino)-3-hydroxy-2,2-dimethyl-4-oxobutyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-N-(3-[[3-(1H-imidazol-1-yl)propyl]amino]-3-oxopropyl)-3,3-dimethylbutanamide
ADP + (3R)-3-hydroxy-4-[(3-[[3-(1H-imidazol-1-yl)propyl]amino]-3-oxopropyl)amino]-2,2-dimethyl-4-oxobutyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-N-[3-(1,3-dihydro-2H-isoindol-2-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
ADP + (3R)-4-[[3-(1,3-dihydro-2H-isoindol-2-yl)-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-N-[3-(2,3-dihydro-1H-indol-1-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
ADP + (3R)-4-[[3-(2,3-dihydro-1H-indol-1-yl)-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-N-[3-(benzylamino)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
ADP + N-benzyl-N3-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide
show the reaction diagram
-
-
-
-
?
ATP + (2R)-N-[3-[(2-butanamidoethyl)amino]-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
ADP + N-(2-butanamidoethyl)-N3-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide
show the reaction diagram
-
-
-
-
?
ATP + (2S)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-[3-oxo-3-(pentylamino)propyl]pentanamide
ADP + N3-[(2S,3S)-2-hydroxy-3-methyl-3-[(phosphonooxy)methyl]pentanoyl]-N-pentyl-beta-alaninamide
show the reaction diagram
-
-
-
-
?
ATP + (2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hept-6-ynamide
ADP + N3-[(2S,3S)-3-ethyl-2-hydroxy-3-[(phosphonooxy)methyl]hept-6-ynoyl]-N-pentyl-beta-alaninamide
show the reaction diagram
-
-
-
-
?
ATP + (2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hex-5-enamide
ADP + (2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]pentanamide
show the reaction diagram
-
-
-
-
?
ATP + (2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hex-5-enamide
ADP + N3-[(2S)-3-ethyl-2-hydroxy-3-[(phosphonooxy)methyl]hex-5-enoyl]-N-pentyl-beta-alaninamide
show the reaction diagram
-
-
-
-
?
ATP + (R)-4-phosphopantoate + beta-alanine
AMP + diphosphate + (R)-4'-phosphopantothenate
show the reaction diagram
the enzyme is involved in coenzyme A biosynthesis in the archaea
-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
show the reaction diagram
ATP + 3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]-2-(pentylamino)propanoate
ADP + 3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]-2-(pentylamino)propanoate
show the reaction diagram
-
-
-
-
?
ATP + D-pantothenate
ADP + 4'-phosphopantothenate
show the reaction diagram
ATP + D-pantothenate
ADP + D-4'-phosphopantothenate
show the reaction diagram
ATP + N-alkylpantothenamides
ADP + ?
show the reaction diagram
growth-inhibiting anti-metabolite, modeling into the active site structure
-
-
?
ATP + N-heptylpantothenamide
ADP + N-heptylpantothenamide 4-phosphate
show the reaction diagram
ATP + N-nonylpantothenamide
ADP + N-nonylpantothenamide 4-phosphate
show the reaction diagram
ATP + N-pentylpantothenamide
ADP + N-pentylpantothenamide 4-phosphate
show the reaction diagram
ATP + N-[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]-beta-alanyl-N-pentylglycinamide
ADP + N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl-N-pentylglycinamide
show the reaction diagram
-
-
-
-
?
ATP + pantheteine
?
show the reaction diagram
-
-
-
-
?
ATP + pantothenate
?
show the reaction diagram
-
-
-
-
?
ATP + pantothenate
ADP + (R)-4'-phosphopantothenate
show the reaction diagram
ATP + pantothenate
ADP + (R)-4-phosphopantothenate
show the reaction diagram
-
-
-
-
?
ATP + pantothenate
ADP + 4'-phosphopantothenate
show the reaction diagram
ATP + pantothenate
ADP + D-4'-phosphopantothenate
show the reaction diagram
-
-
-
-
?
ATP + pantothenol
ADP + 4'-phosphopantothenol
show the reaction diagram
CTP + (R)-pantothenate
CDP + (R)-4'-phosphopantothenate
show the reaction diagram
-
-
-
?
GTP + (R)-pantothenate
GDP + (R)-4'-phosphopantothenate
show the reaction diagram
GTP + pantothenate
GDP + D-4'-phosphopantothenate
show the reaction diagram
ITP + pantothenate
IDP + D-4'-phosphopantothenate
show the reaction diagram
-
phosphorylation at 46% the rate of ATP
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-
?
pantetheine + ATP
D-4'-phosphopantetheine + ADP
show the reaction diagram
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-
-
-
?
panthenoylcysteine + ATP
D-4'-phosphopanthenoylcysteine + ADP
show the reaction diagram
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-
-
-
?
pantothenate + ATP
4'-phosphopantothenate + ADP
show the reaction diagram
pantothenate + ATP
phosphopantothenate + ADP
show the reaction diagram
pantothenate + CTP
4'-phosphopantothenate + CDP
show the reaction diagram
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-
-
-
?
pantothenate + dATP
4'-phosphopantothenate + dADP
show the reaction diagram
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-
-
-
?
pantothenate + dCTP
4'-phosphopantothenate + dCDP
show the reaction diagram
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-
-
-
?
pantothenate + dGTP
4'-phosphopantothenate + dGDP
show the reaction diagram
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-
-
-
?
pantothenate + dTTP
4'-phosphopantothenate + dTDP
show the reaction diagram
-
-
-
-
?
pantothenate + UTP
4'-phosphopantothenate + UDP
show the reaction diagram
-
-
-
-
?
pantothenyl alcohol + ATP
D-4'-phosphopantothenyl alcohol + ADP
show the reaction diagram
-
-
-
-
?
UTP + pantothenate
UDP + D-4'-phosphopantothenate
show the reaction diagram
-
phosphorylation at 18% the rate of ATP
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-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + (R)-4-phosphopantoate + beta-alanine
AMP + diphosphate + (R)-4'-phosphopantothenate
show the reaction diagram
Q5JHF1
the enzyme is involved in coenzyme A biosynthesis in the archaea
-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
show the reaction diagram
ATP + D-pantothenate
ADP + D-4'-phosphopantothenate
show the reaction diagram
ATP + N-heptylpantothenamide
ADP + N-heptylpantothenamide 4-phosphate
show the reaction diagram
ATP + pantothenate
ADP + (R)-4'-phosphopantothenate
show the reaction diagram
-
first step of the pathway from pantothenate to CoA. The activity of this protein is tightly regulated by CoA feedback inhibition, both in vitro and in vivo
-
-
?
ATP + pantothenate
ADP + 4'-phosphopantothenate
show the reaction diagram
Q8TE04, Q9H999
pantothenate kinase catalyzes the first step in CoA biosynthesis
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
CTP
less active than ATP
GTP
less active than ATP
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Co2+
-
activation, can replace Mg2+
Ni2+
-
activation, can replace Mg2+ with about 50% efficiency
Zn2+
-
activation, can replace Mg2+ with about 50% efficiency
additional information
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2R)-2,4-dihydroxy-3,3-dimethyl-N'-phenylbutanohydrazide
(2R)-2,4-dihydroxy-3,3-dimethylbutanohydrazide
-
competitive, pantothenic acid analogue with 2,4-dihydroxy-3,3-dimethylbutyramide core of pantothenate, inhibition mechanism
(2R)-2,4-dihydroxy-N-(2-hydroxyethyl)-3,3-dimethylbutanamide
-
competitive, pantothenic acid analogue with 2,4-dihydroxy-3,3-dimethylbutyramide core of pantothenate, inhibition mechanism
(2R)-N-(2,3-dihydroxypropyl)-2,4-dihydroxy-3,3-dimethylbutanamide
-
competitive, pantothenic acid analogue with 2,4-dihydroxy-3,3-dimethylbutyramide core of pantothenate, inhibition mechanism
(2R)-N-allyl-2,4-dihydroxy-3,3-dimethylbutanamide
(R)-3-azido-4,4-dimethyl-dihydro-furan-2-one
(R)-4-(2,4-dihydroxy-3,3-dimethyl-butyrylamino)-butyric acid
(R)-4-(2-amino-4-hydroxy-3,3-dimethyl-butyrylamino)-butyric acid
(R)-4-(2-azido-4-hydroxy-3,3-dimethyl-butyrylamino)-butyric acid
(S)-4-(2,4-dihydroxy-3,3-dimethyl-butyrylamino)-butyric acid
(S)-trifluoro-methanesulfonic acid 4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl-ester
1,4-dioxa-8-azaspiro[4.5]dec-8-yl[2-[(3-fluorophenyl)sulfanyl]pyridin-4-yl]methanone
-
mixed non-competitive inhibition
1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea dihydrobromide
-
2'-Ketopantetheine
-
-
2,4-dihydroxy-3,3-dimethyl N-(2-heptylcarbamoyl-ethyl)-butyramide
2,4-dihydroxy-3,3-dimethyl N-(2-isobutylcarbamoyl-ethyl)-butyramide
2,4-dihydroxy-3,3-dimethyl N-(2-pentylcarbamoyl-ethyl)-butyramide
2,4-dihydroxy-3,3-dimethyl N-(2-phenethylcarbamoyl-ethyl)-butyramide
2,4-dihydroxy-3,3-dimethyl N-(2-propylcarbamoylethyl)-butyramide
2,4-dihydroxy-3,3-dimethyl N-(2-[1-methyl-3-phenyl-propylcarbamoyl]-ethyl)-butyramide
2,4-dihydroxy-3,3-dimethyl N-(2-[2-(3,4-dimethoxy-phenyl)-ethylcarbamoyl]-ethyl)-butyramide
2,4-dihydroxy-3,3-dimethyl N-(2-[3,4,5-trimethoxy-benzylcarbamoyl]-ethyl)-butyramide
2,4-dihydroxy-3,3-dimethyl N-[2-(2,6,6-trimethylbicyclo[3.1.1]hept-3-ylcarbamoyl)-ethyl]-butyramide
2,4-dihydroxy-3,3-dimethyl N-[2-(2-ethoxy-ethylcarbamoyl)-ethyl]-butyramide
2,4-dihydroxy-3,3-dimethyl N-[2-(2-ethylsulfanylethylcarbamoyl)-ethyl]-butyramide
2,4-dihydroxy-3,3-dimethyl N-[2-(2-methylsulfanylethylcarbamoyl)-ethyl]-butyramide
2,4-dihydroxy-3,3-dimethyl N-[2-(2-morpholin-4-yl-ethylcarbamoyl)-ethyl]-butyramide
2,4-dihydroxy-3,3-dimethyl N-[2-(3,7-dimethylocta-2,6-dienylcarbamoyl)-ethyl]-butyramide
2,4-dihydroxy-3,3-dimethyl N-[2-(3-ethoxy-propylcarbamoyl)-ethyl]-butyramide
2,4-dihydroxy-3,3-dimethyl N-[2-(3-methylsulfanylpropylcarbamoyl)-ethyl]-butyramide
2,4-dihydroxy-3,3-dimethyl N-[2-(4-methoxy-benzylcarbamoyl)-ethyl]-3,3-dimethyl-butyramide
2,4-dihydroxy-3,3-dimethyl N-[3-(4-benzyl-piperazin-1-yl)-3-oxo-propyl]-butyramide
2,4-dihydroxy-N-[2-(2-hydroxy-ethylcarbamoyl)-ethyl]-3,3-dimethyl-butyramide
2,4-dihydroxy-N-[2-(2-methoxy-ethylcarbamoyl)-ethyl]-3,3-dimethyl-butyramide
2,4-dihydroxy-N-[2-(3-hydroxy-propylcarbamoyl)-ethyl]-3,3-dimethyl-butyramide
2,4-dihydroxy-N-[2-(3-methoxy-propylcarbamoyl)-ethyl]-3,3-dimethyl-butyramide
2,6-difluoro-N-[1-(5-[[2-(4-fluorophenoxy)ethyl]sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl)ethyl]benzamide
-
competitive inhibition
2-chloro-N-[1-(5-[[2-(4-fluorophenoxy)ethyl]sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl)ethyl]benzamide
-
competitive inhibition
2-[(4'-cyano-2-[[4-(pyridin-2-yl)piperazin-1-yl]methyl][1,1'-biphenyl]-4-yl)oxy]-1-oxoethan-1-aminide
-
non-competitive inhibition
2-[2-(1-benzoylpiperidin-4-yl)-5-methyl-1,3-thiazol-4-yl]-N-(4-methylphenyl)acetamide
-
uncompetitive inhibition
4-(2,4-dihydroxy-3,3-dimethylbutylamido)butyric acid
-
competitive inhibitor; competitive inhibitor, IC50: 0.05-0.15 mM
4-phosphopantoate
substrate inhibition
5'-deoxy-5'-(4-(beta-D-galactopyranosyloxymethyl)-1,2,3-triazol-1-yl)adenosine
-
competitive inhibitor with respect to ATP
acetoacetyl-CoA
-
-
acetyl-CoA
Acyl carrier protein
acyl-CoA-esters
Arachidonoyl-CoA
-
-
chloranil
-
CoA esters
-
feedback inhibition, inhibition kinetics of recombinant isozyme mPanK2
coenzyme A
D-pantothenate
-
substrate inhibition, above 0.5 mM
dehydroisoandrosterone
about 30% residual activity at 0.1 mM (isoform PanK3)
Dehydroisoandrosterone sulfate
; about 8% residual activity at 0.1 mM (isoform PanK3)
dephospho-CoA
diphosphate
-
-
ephedrine hydrochloride
-
estradiol
about 80% residual activity at 0.1 mM (isoform PanK3)
Estradiol sulfate
about 90% residual activity at 0.1 mM (isoform PanK3)
Estrone sulfate
about 50% residual activity at 0.1 mM (isoform PanK3)
Fusidic acid
-
glipizide
-
glyburide
-
Hexachlorophene
-
L-Pantothenate
-
-
malonyl-CoA
MCC-555
MCC-555 inhibits all three isoforms with a rank order of PanK3 > PanK2 > PanK1b; MCC-555 inhibits all three isoforms with a rank order of PanK3 > PanK2 > PanK1b
N-(1-[5-[(4-fluorobenzyl)sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl]ethyl)-2-(trifluoromethyl)benzamide
-
competitive inhibition
N-heptylpantothenamide
N-pentylpantothenamide
N-[1-(5-[[2-(4-chlorophenoxy)ethyl]sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl)ethyl]naphthalene-1-carboxamide
-
competitive inhibition
N-[1-(5-[[2-(4-fluorophenoxy)ethyl]sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl)ethyl]-2-(trifluoromethyl)benzamide
-
competitive inhibition
N-[1-(5-[[2-(4-fluorophenoxy)ethyl]sulfanyl]-4-[(4-fluorophenyl)methyl]-4H-1,2,4-triazol-3-yl)ethyl]-2-(trifluoromethyl)benzamide
-
competitive inhibition
Octanoyl-CoA
-
-
oleoyl-CoA
-
-
palmitoyl-CoA
pantetheine 4'-phosphate
pantothenamide, N-substituted
-
IC50 about 0.0004-0.0016 mM
-
pantothenic acid 4'-phosphate
-
-
pantothenol
-
competitive inhibition
pantothenoylcysteine 4'-phosphate
pantothenyl alcohol
-
-
pioglitazone hydrochloride
-
pregnenolone sulfate
; about 10% residual activity at 0.1 mM (isoform PanK3); about 92% residual activity at 0.1 mM (isoform PanK3)
propionyl-CoA
-
-
Psi-rhodomyrtoxin
-
Reactive blue 2
-
Ro 41-0960
-
rosiglitazone
-
succinyl-CoA
-
-
tamoxifen
-
tolfenamic acid
-
tyrphostin AG 528
-
tyrphostin AG 808
-
WIN 62577
-
[(4'-cyano-2-[[4-(pyridin-2-yl)piperazin-1-yl]methyl][1,1'-biphenyl]-4-yl)oxy]acetic acid
-
non-competitive inhibition
[2-[(3-chlorophenyl)sulfanyl]pyridin-4-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
-
mixed non-competitive inhibition
[2-[(3-chlorophenyl)sulfanyl]quinolin-4-yl](piperidin-1-yl)methanone
-
mixed non-competitive inhibition
[[2-[[4-(6-methylpyridin-2-yl)piperazin-1-yl]methyl]-4'-(trifluoromethoxy)biphenyl-4-yl]oxy]acetic acid
-
mixed non-competitive inhibition
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Acyl carrier protein
-
PAK II: inhibition, PAK I: stimulation between 0.015-0.035 mM
cholesterol
about 125% activity at 0.1 mM
CoA
-
stimulates
dithiothreitol
-
activation
glyburide
; isoform PanK1b is activated by glyburide
O-oleoylcarnitine
140% activation at 0.1 mM
O-palmitoylcarnitine
120% activation at 0.1 mM
oleoylethanolamide
120% activation at 0.1 mM
palmitoylcarnitine
tamoxifen
140% activation at 0.1 mM
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[(piperidin-4-yl)methyl]amino]propyl)butanamide
-
at pH 7.6, temperature not specified in the publication
1
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(piperazin-1-yl)ethyl]amino]propyl)butanamide
-
at pH 7.6, temperature not specified in the publication
0.11
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(pyridin-2-yl)ethyl]amino]propyl)butanamide
-
at pH 7.6, temperature not specified in the publication
1.2
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[2-oxo-2-(pentylamino)ethyl]amino]propyl)butanamide
-
at pH 7.6, temperature not specified in the publication
0.35
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[3-(morpholin-4-yl)propyl]amino]-3-oxopropyl)butanamide
-
at pH 7.6, temperature not specified in the publication
0.19
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[(1-pentyl-1H-1,2,3-triazol-4-yl)methyl]butanamide
-
at pH 7.6, temperature not specified in the publication
1
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-(1-propyl-1H-1,2,3-triazol-4-yl)propyl]butanamide
-
at pH 7.6, temperature not specified in the publication
0.036
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pentylamino)propyl]butanamide
-
at pH 7.6, temperature not specified in the publication
0.043
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(phenylamino)propyl]butanamide
-
at pH 7.6, temperature not specified in the publication
0.45
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pyrimidin-4-ylamino)propyl]butanamide
-
at pH 7.6, temperature not specified in the publication
0.032
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(3-phenylpropyl)amino]propyl]butanamide
-
at pH 7.6, temperature not specified in the publication
0.05
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-2-ylmethyl)amino]propyl]butanamide
-
at pH 7.6, temperature not specified in the publication
0.033
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-3-ylmethyl)amino]propyl]butanamide
-
at pH 7.6, temperature not specified in the publication
0.13
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-4-ylmethyl)amino]propyl]butanamide
-
at pH 7.6, temperature not specified in the publication
0.039
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-[(3-methylpyridin-2-yl)amino]-3-oxopropyl]butanamide
-
at pH 7.6, temperature not specified in the publication
0.022
(2R)-2,4-dihydroxy-N-(3-[[3-(1H-imidazol-1-yl)propyl]amino]-3-oxopropyl)-3,3-dimethylbutanamide
-
at pH 7.6, temperature not specified in the publication
0.2
(2R)-N-[3-(1,3-dihydro-2H-isoindol-2-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
-
at pH 7.6, temperature not specified in the publication
0.4
(2R)-N-[3-(2,3-dihydro-1H-indol-1-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
-
at pH 7.6, temperature not specified in the publication
0.067
(2R)-N-[3-(benzylamino)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
-
at pH 7.6, temperature not specified in the publication
0.24
(2R)-N-[3-[(2-butanamidoethyl)amino]-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
-
at pH 7.6, temperature not specified in the publication
0.23
(2S)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-[3-oxo-3-(pentylamino)propyl]pentanamide
-
at pH 7.6, temperature not specified in the publication
0.11
(2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hept-6-ynamide
-
at pH 7.6, temperature not specified in the publication
0.59 - 1.2
(2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hex-5-enamide
0.0057 - 0.168
(R)-pantothenate
0.7
3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]-2-(pentylamino)propanoate
-
at pH 7.6, temperature not specified in the publication
0.027 - 9.59
ATP
1.759
CTP
-
-
0.138
dATP
-
-
0.839
dCTP
-
-
0.117
dGTP
-
-
0.723
dTTP
-
-
668
GTP
-
in citrate buffer, pH 6.5, temperature not specified in the publication
0.225 - 1
MgATP2-
0.008 - 0.124
N-heptylpantothenamide
0.003 - 0.14
N-pentylpantothenamide
0.12
N-[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]-beta-alanyl-N-pentylglycinamide
-
at pH 7.6, temperature not specified in the publication
0.06
pantheteine
-
at pH 7.6, temperature not specified in the publication
-
0.009 - 1.3
pantothenate
0.25 - 0.28
pantothenol
1.715
UTP
-
-
additional information
additional information
-
kinetics of recombinant isozyme mPanK2
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.19
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[(piperidin-4-yl)methyl]amino]propyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.75
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(piperazin-1-yl)ethyl]amino]propyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.15
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(pyridin-2-yl)ethyl]amino]propyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.13
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[2-oxo-2-(pentylamino)ethyl]amino]propyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.03
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[3-(morpholin-4-yl)propyl]amino]-3-oxopropyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.96
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[(1-pentyl-1H-1,2,3-triazol-4-yl)methyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.49
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-(1-propyl-1H-1,2,3-triazol-4-yl)propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.93
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pentylamino)propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.02
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(phenylamino)propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.44
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pyrimidin-4-ylamino)propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.13
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(3-phenylpropyl)amino]propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.02
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-2-ylmethyl)amino]propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.24
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-3-ylmethyl)amino]propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.94
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-4-ylmethyl)amino]propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.78
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-[(3-methylpyridin-2-yl)amino]-3-oxopropyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.46
(2R)-2,4-dihydroxy-N-(3-[[3-(1H-imidazol-1-yl)propyl]amino]-3-oxopropyl)-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.45
(2R)-N-[3-(1,3-dihydro-2H-isoindol-2-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.18
(2R)-N-[3-(2,3-dihydro-1H-indol-1-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.15
(2R)-N-[3-(benzylamino)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.09
(2R)-N-[3-[(2-butanamidoethyl)amino]-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.17
(2S)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-[3-oxo-3-(pentylamino)propyl]pentanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.04
(2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hept-6-ynamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.28 - 0.89
(2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hex-5-enamide
0.29 - 2.12
(R)-pantothenate
0.23
3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]-2-(pentylamino)propanoate
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.052 - 2.12
ATP
1.5
CTP
Bacillus anthracis
-
-
0.9
dATP
Bacillus anthracis
-
-
0.5
dCTP
Bacillus anthracis
-
-
0.8
dGTP
Bacillus anthracis
-
-
0.4
dTTP
Bacillus anthracis
-
-
0.064
GTP
Mycobacterium tuberculosis
-
in citrate buffer, pH 6.5, temperature not specified in the publication
0.425
N-heptylpantothenamide
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant enzyme
0.15
N-pentylpantothenamide
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant enzyme
1.12
N-[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]-beta-alanyl-N-pentylglycinamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.03
pantheteine
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
-
0.61 - 0.818
pantothenate
0.38 - 0.4
pantothenol
1.7
UTP
Bacillus anthracis
-
-
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.5
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[(piperidin-4-yl)methyl]amino]propyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214045
0.3
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(piperazin-1-yl)ethyl]amino]propyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214046
11
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(pyridin-2-yl)ethyl]amino]propyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214031
0.1
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[2-oxo-2-(pentylamino)ethyl]amino]propyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214047
2.9
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[3-(morpholin-4-yl)propyl]amino]-3-oxopropyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214039
5.1
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[(1-pentyl-1H-1,2,3-triazol-4-yl)methyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214035
0.5
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-(1-propyl-1H-1,2,3-triazol-4-yl)propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214044
26
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pentylamino)propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214023
24
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(phenylamino)propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214028
3.2
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pyrimidin-4-ylamino)propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214041
35
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(3-phenylpropyl)amino]propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214025
20
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-2-ylmethyl)amino]propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214029
38
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-3-ylmethyl)amino]propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214026
7
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-4-ylmethyl)amino]propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214034
20
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-[(3-methylpyridin-2-yl)amino]-3-oxopropyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214027
21
(2R)-2,4-dihydroxy-N-(3-[[3-(1H-imidazol-1-yl)propyl]amino]-3-oxopropyl)-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214024
1.9
(2R)-N-[3-(1,3-dihydro-2H-isoindol-2-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214036
0.4
(2R)-N-[3-(2,3-dihydro-1H-indol-1-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214040
17
(2R)-N-[3-(benzylamino)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214030
4.5
(2R)-N-[3-[(2-butanamidoethyl)amino]-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214038
5.1
(2S)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-[3-oxo-3-(pentylamino)propyl]pentanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214037
9
(2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hept-6-ynamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214032
0.2 - 1.5
(2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hex-5-enamide
214042
50
(R)-pantothenate
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
2630
0.3
3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]-2-(pentylamino)propanoate
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214043
0.08 - 9.91
ATP
4
0.9
CTP
Bacillus anthracis
-
-
60
6.6
dATP
Bacillus anthracis
-
-
140
0.6
dCTP
Bacillus anthracis
-
-
179
6.5
dGTP
Bacillus anthracis
-
-
219
0.5
dTTP
Bacillus anthracis
-
-
145
0.095
GTP
Mycobacterium tuberculosis
-
in citrate buffer, pH 6.5, temperature not specified in the publication
37
10
N-[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]-beta-alanyl-N-pentylglycinamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214033
17
pantheteine
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214022
1
UTP
Bacillus anthracis
-
-
65
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.138 - 0.2
(2R)-2,4-dihydroxy-3,3-dimethyl-N'-phenylbutanohydrazide
0.013
(2R)-2,4-dihydroxy-3,3-dimethylbutanohydrazide
-
37°C, versus pantothenate at 1 mM
0.0019
(2R)-2,4-dihydroxy-N-(2-hydroxyethyl)-3,3-dimethylbutanamide
-
37°C, versus pantothenate at 1 mM
4
(2R)-N-(2,3-dihydroxypropyl)-2,4-dihydroxy-3,3-dimethylbutanamide
-
37°C, versus pantothenate at 1 mM
0.082 - 1
(2R)-N-allyl-2,4-dihydroxy-3,3-dimethylbutanamide
0.162
2,4-dihydroxy-3,3-dimethyl N-(2-pentylcarbamoyl-ethyl)-butyramide
-
37°C, versus pantothenate at 1 mM
0.112
2,4-dihydroxy-3,3-dimethyl N-(2-propylcarbamoylethyl)-butyramide
-
37°C, versus pantothenate at 1 mM
0.111
2,4-dihydroxy-3,3-dimethyl N-[2-(3-ethoxy-propylcarbamoyl)-ethyl]-butyramide
-
37°C, versus pantothenate at 1 mM
0.076
2,4-dihydroxy-3,3-dimethyl N-[2-(3-methylsulfanylpropylcarbamoyl)-ethyl]-butyramide
-
37°C, versus pantothenate at 1 mM
0.109
2,4-dihydroxy-N-[2-(3-methoxy-propylcarbamoyl)-ethyl]-3,3-dimethyl-butyramide
-
37°C, versus pantothenate at 1 mM
0.164
5'-deoxy-5'-(4-(beta-D-galactopyranosyloxymethyl)-1,2,3-triazol-1-yl)adenosine
-
-
0.002 - 0.067
CoA
0.037
pantetheine 4'-phosphate
-
pH 6.5, 37°C
0.125
pantothenic acid 4'-phosphate
-
pH 6.5, 37°C
0.129
pantothenol
-
37°C, versus pantothenate at 1 mM
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0084
1,4-dioxa-8-azaspiro[4.5]dec-8-yl[2-[(3-fluorophenyl)sulfanyl]pyridin-4-yl]methanone
Mycobacterium tuberculosis
-
in 50 mM PIPES-NaOH (pH 7.0), 25 mM KCl, 20 mM MgCl, at 25°C
0.0004
1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea dihydrobromide
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37°C
0.00257
2-[2-(1-benzoylpiperidin-4-yl)-5-methyl-1,3-thiazol-4-yl]-N-(4-methylphenyl)acetamide
Mycobacterium tuberculosis
-
in 50 mM PIPES-NaOH (pH 7.0), 25 mM KCl, 20 mM MgCl, at 25°C
0.05 - 0.15
4-(2,4-dihydroxy-3,3-dimethylbutylamido)butyric acid
Mus musculus
-
competitive inhibitor, IC50: 0.05-0.15 mM
0.00006 - 0.000125
acetyl-CoA
0.0059
chloranil
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37°C
0.2
CoA
Plasmodium falciparum
-
IC50: 0.2 mM
0.0035
Dehydroisoandrosterone sulfate
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37°C
0.0016
ephedrine hydrochloride
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37°C
0.0001
Fusidic acid
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37°C
0.0052
glipizide
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37°C
0.0068
glyburide
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37°C
0.0092
GW5074
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37°C
0.0088
Hexachlorophene
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37°C
0.0048
N-heptylpantothenamide
Staphylococcus aureus
-
IC50 is 0.0048 mM, potent growth inhibitory anti-metabolite
0.0035
N-pentylpantothenamide
Staphylococcus aureus
-
IC50 is 0.0035 mM, has antimicrobial activity against Staphylococcus aureus
0.00007
N-[1-(5-[[2-(4-chlorophenoxy)ethyl]sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl)ethyl]naphthalene-1-carboxamide
Mycobacterium tuberculosis
-
in 50 mM PIPES-NaOH (pH 7.0), 25 mM KCl, 20 mM MgCl, at 25°C
0.0004 - 0.0016
pantothenamide, N-substituted
Staphylococcus aureus
-
IC50 about 0.0004-0.0016 mM
-
0.001
pioglitazone hydrochloride
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37°C
0.0025
pregnenolone sulfate
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37°C
0.0016
Psi-rhodomyrtoxin
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37°C
0.0013
Reactive blue 2
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37°C
0.0039
Ro 41-0960
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37°C
0.0017
rosiglitazone
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37°C
0.0092
tolfenamic acid
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37°C
0.003
tyrphostin AG 528
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37°C
0.009
tyrphostin AG 808
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37°C
0.0007
WIN 62577
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37°C
0.00024 - 0.00042
[2-[(3-chlorophenyl)sulfanyl]pyridin-4-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
0.00087
[2-[(3-chlorophenyl)sulfanyl]quinolin-4-yl](piperidin-1-yl)methanone
Mycobacterium tuberculosis
-
in 50 mM PIPES-NaOH (pH 7.0), 25 mM KCl, 20 mM MgCl, at 25°C
0.00082
[[2-[[4-(6-methylpyridin-2-yl)piperazin-1-yl]methyl]-4'-(trifluoromethoxy)biphenyl-4-yl]oxy]acetic acid
Mycobacterium tuberculosis
-
in 50 mM PIPES-NaOH (pH 7.0), 25 mM KCl, 20 mM MgCl, at 25°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0002421
-
0.045 mM pantothenate, 0.25 mM ATP (pH 7.0), 10 mM MgCl2, 0.1 M Tris/HCl (pH 7.5), at 37°C
0.0012
-
pH 6.1, 37°C
0.00171
-
pH 7.0, 37°C
0.0041
-
pH 6.1, 37°C
0.034
-
pH 6.5, 37°C
0.152
-
isoform 1, 37°C, pH 8.0
0.36
purified recombinant protein
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.9 - 6.3
-
-
6 - 9
-
broad, highest activity in 50 mM phosphate buffer
7
-
assay at
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4.5 - 6
more than 70% of the maximum activity
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
15
the enzyme has no activity at temperatures below 15°C
30 - 42
-
-
50 - 70
more than 80% of the maximum activity
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.1
-
isoelectric focusing, isoform B
5.7
-
isoelectric focusing, isoform A
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
LOCALIZATION