Information on EC 2.7.1.33 - pantothenate kinase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY hide
2.7.1.33
-
RECOMMENDED NAME
GeneOntology No.
pantothenate kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Metabolic pathways
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Pantothenate and CoA biosynthesis
-
-
phosphopantothenate biosynthesis I
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phosphopantothenate biosynthesis II
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superpathway of coenzyme A biosynthesis III (mammals)
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coenzyme A metabolism
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SYSTEMATIC NAME
IUBMB Comments
ATP:(R)-pantothenate 4'-phosphotransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9026-48-6
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
ecotype Colombia-0
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
-
-
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Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
no activity in Lactobacillus helveticus
-
-
-
Manually annotated by BRENDA team
no activity in Neurospora crassa
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
Sprague-Dawley
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-
Manually annotated by BRENDA team
spinach
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Manually annotated by BRENDA team
strain RN4220, gene coaA
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-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
pantothenate kinase catalyzes the rate-controlling step in coenzyme A biosynthesis; pantothenate kinase catalyzes the rate-controlling step in coenzyme A biosynthesis
physiological function
additional information
-
mitochondria-targeted human pantothenate kinase-2 is involved in pantothenate kinase-associated neurodegeneration
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[(piperidin-4-yl)methyl]amino]propyl)butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-[[(piperidin-4-yl)methyl]amino]propyl)amino]butyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(piperazin-1-yl)ethyl]amino]propyl)butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-[[2-(piperazin-1-yl)ethyl]amino]propyl)amino]butyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(pyridin-2-yl)ethyl]amino]propyl)butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-[[2-(pyridin-2-yl)ethyl]amino]propyl)amino]butyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[2-oxo-2-(pentylamino)ethyl]amino]propyl)butanamide
ADP + N2-(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propyl)-N-pentylglycinamide
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[3-(morpholin-4-yl)propyl]amino]-3-oxopropyl)butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-[(3-[[3-(morpholin-4-yl)propyl]amino]-3-oxopropyl)amino]-4-oxobutyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[(1-pentyl-1H-1,2,3-triazol-4-yl)methyl]butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[(1-pentyl-1H-1,2,3-triazol-4-yl)methyl]amino]butyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-(1-propyl-1H-1,2,3-triazol-4-yl)propyl]butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-(1-propyl-1H-1,2,3-triazol-4-yl)propyl]amino]butyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pentylamino)propyl]butanamide
ADP + N3-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-pentyl-beta-alaninamide
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(phenylamino)propyl]butanamide
ADP + N3-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-phenyl-beta-alaninamide
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pyrimidin-4-ylamino)propyl]butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-([3-oxo-3-[(pyrimidin-4-yl)amino]propyl]amino)butyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(3-phenylpropyl)amino]propyl]butanamide
ADP + N3-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(3-phenylpropyl)-beta-alaninamide
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-2-ylmethyl)amino]propyl]butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-[[(pyridin-2-yl)methyl]amino]propyl)amino]butyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-3-ylmethyl)amino]propyl]butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-[[(pyridin-3-yl)methyl]amino]propyl)amino]butyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-4-ylmethyl)amino]propyl]butanamide
ADP + (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-[[(pyridin-4-yl)methyl]amino]propyl)amino]butyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-[(3-methylpyridin-2-yl)amino]-3-oxopropyl]butanamide
ADP + (3R)-4-([3-[(3-aminopyridin-2-yl)amino]-3-oxopropyl]amino)-3-hydroxy-2,2-dimethyl-4-oxobutyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-2,4-dihydroxy-N-(3-[[3-(1H-imidazol-1-yl)propyl]amino]-3-oxopropyl)-3,3-dimethylbutanamide
ADP + (3R)-3-hydroxy-4-[(3-[[3-(1H-imidazol-1-yl)propyl]amino]-3-oxopropyl)amino]-2,2-dimethyl-4-oxobutyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-N-[3-(1,3-dihydro-2H-isoindol-2-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
ADP + (3R)-4-[[3-(1,3-dihydro-2H-isoindol-2-yl)-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-N-[3-(2,3-dihydro-1H-indol-1-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
ADP + (3R)-4-[[3-(2,3-dihydro-1H-indol-1-yl)-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl dihydrogen phosphate
show the reaction diagram
-
-
-
-
?
ATP + (2R)-N-[3-(benzylamino)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
ADP + N-benzyl-N3-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide
show the reaction diagram
-
-
-
-
?
ATP + (2R)-N-[3-[(2-butanamidoethyl)amino]-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
ADP + N-(2-butanamidoethyl)-N3-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide
show the reaction diagram
-
-
-
-
?
ATP + (2S)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-[3-oxo-3-(pentylamino)propyl]pentanamide
ADP + N3-[(2S,3S)-2-hydroxy-3-methyl-3-[(phosphonooxy)methyl]pentanoyl]-N-pentyl-beta-alaninamide
show the reaction diagram
-
-
-
-
?
ATP + (2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hept-6-ynamide
ADP + N3-[(2S,3S)-3-ethyl-2-hydroxy-3-[(phosphonooxy)methyl]hept-6-ynoyl]-N-pentyl-beta-alaninamide
show the reaction diagram
-
-
-
-
?
ATP + (2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hex-5-enamide
ADP + (2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]pentanamide
show the reaction diagram
-
-
-
-
?
ATP + (2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hex-5-enamide
ADP + N3-[(2S)-3-ethyl-2-hydroxy-3-[(phosphonooxy)methyl]hex-5-enoyl]-N-pentyl-beta-alaninamide
show the reaction diagram
-
-
-
-
?
ATP + (R)-4-phosphopantoate + beta-alanine
AMP + diphosphate + (R)-4'-phosphopantothenate
show the reaction diagram
the enzyme is involved in coenzyme A biosynthesis in the archaea
-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
show the reaction diagram
ATP + 3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]-2-(pentylamino)propanoate
ADP + 3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]-2-(pentylamino)propanoate
show the reaction diagram
-
-
-
-
?
ATP + D-pantothenate
ADP + 4'-phosphopantothenate
show the reaction diagram
ATP + D-pantothenate
ADP + D-4'-phosphopantothenate
show the reaction diagram
ATP + N-alkylpantothenamides
ADP + ?
show the reaction diagram
growth-inhibiting anti-metabolite, modeling into the active site structure
-
-
?
ATP + N-heptylpantothenamide
ADP + N-heptylpantothenamide 4-phosphate
show the reaction diagram
ATP + N-nonylpantothenamide
ADP + N-nonylpantothenamide 4-phosphate
show the reaction diagram
ATP + N-pentylpantothenamide
ADP + N-pentylpantothenamide 4-phosphate
show the reaction diagram
ATP + N-[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]-beta-alanyl-N-pentylglycinamide
ADP + N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl-N-pentylglycinamide
show the reaction diagram
-
-
-
-
?
ATP + pantheteine
?
show the reaction diagram
-
-
-
-
?
ATP + pantothenate
?
show the reaction diagram
-
-
-
-
?
ATP + pantothenate
ADP + (R)-4'-phosphopantothenate
show the reaction diagram
ATP + pantothenate
ADP + (R)-4-phosphopantothenate
show the reaction diagram
-
-
-
-
?
ATP + pantothenate
ADP + 4'-phosphopantothenate
show the reaction diagram
ATP + pantothenate
ADP + D-4'-phosphopantothenate
show the reaction diagram
-
-
-
-
?
ATP + pantothenol
ADP + 4'-phosphopantothenol
show the reaction diagram
CTP + (R)-pantothenate
CDP + (R)-4'-phosphopantothenate
show the reaction diagram
-
-
-
?
GTP + (R)-pantothenate
GDP + (R)-4'-phosphopantothenate
show the reaction diagram
GTP + pantothenate
GDP + D-4'-phosphopantothenate
show the reaction diagram
ITP + pantothenate
IDP + D-4'-phosphopantothenate
show the reaction diagram
-
phosphorylation at 46% the rate of ATP
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-
?
pantetheine + ATP
D-4'-phosphopantetheine + ADP
show the reaction diagram
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-
-
-
?
panthenoylcysteine + ATP
D-4'-phosphopanthenoylcysteine + ADP
show the reaction diagram
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-
-
-
?
pantothenate + ATP
4'-phosphopantothenate + ADP
show the reaction diagram
pantothenate + ATP
phosphopantothenate + ADP
show the reaction diagram
pantothenate + CTP
4'-phosphopantothenate + CDP
show the reaction diagram
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-
-
-
?
pantothenate + dATP
4'-phosphopantothenate + dADP
show the reaction diagram
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-
-
-
?
pantothenate + dCTP
4'-phosphopantothenate + dCDP
show the reaction diagram
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-
-
-
?
pantothenate + dGTP
4'-phosphopantothenate + dGDP
show the reaction diagram
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-
-
-
?
pantothenate + dTTP
4'-phosphopantothenate + dTDP
show the reaction diagram
-
-
-
-
?
pantothenate + UTP
4'-phosphopantothenate + UDP
show the reaction diagram
-
-
-
-
?
pantothenyl alcohol + ATP
D-4'-phosphopantothenyl alcohol + ADP
show the reaction diagram
-
-
-
-
?
UTP + pantothenate
UDP + D-4'-phosphopantothenate
show the reaction diagram
-
phosphorylation at 18% the rate of ATP
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-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + (R)-4-phosphopantoate + beta-alanine
AMP + diphosphate + (R)-4'-phosphopantothenate
show the reaction diagram
Q5JHF1
the enzyme is involved in coenzyme A biosynthesis in the archaea
-
-
?
ATP + (R)-pantothenate
ADP + (R)-4'-phosphopantothenate
show the reaction diagram
ATP + D-pantothenate
ADP + D-4'-phosphopantothenate
show the reaction diagram
ATP + N-heptylpantothenamide
ADP + N-heptylpantothenamide 4-phosphate
show the reaction diagram
ATP + pantothenate
ADP + (R)-4'-phosphopantothenate
show the reaction diagram
-
first step of the pathway from pantothenate to CoA. The activity of this protein is tightly regulated by CoA feedback inhibition, both in vitro and in vivo
-
-
?
ATP + pantothenate
ADP + 4'-phosphopantothenate
show the reaction diagram
Q8TE04, Q9H999
pantothenate kinase catalyzes the first step in CoA biosynthesis
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
CTP
less active than ATP
GTP
less active than ATP
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Co2+
-
activation, can replace Mg2+
Ni2+
-
activation, can replace Mg2+ with about 50% efficiency
Zn2+
-
activation, can replace Mg2+ with about 50% efficiency
additional information
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2R)-2,4-dihydroxy-3,3-dimethyl-N'-phenylbutanohydrazide
(2R)-2,4-dihydroxy-3,3-dimethylbutanohydrazide
-
competitive, pantothenic acid analogue with 2,4-dihydroxy-3,3-dimethylbutyramide core of pantothenate, inhibition mechanism
(2R)-2,4-dihydroxy-N-(2-hydroxyethyl)-3,3-dimethylbutanamide
-
competitive, pantothenic acid analogue with 2,4-dihydroxy-3,3-dimethylbutyramide core of pantothenate, inhibition mechanism
(2R)-N-(2,3-dihydroxypropyl)-2,4-dihydroxy-3,3-dimethylbutanamide
-
competitive, pantothenic acid analogue with 2,4-dihydroxy-3,3-dimethylbutyramide core of pantothenate, inhibition mechanism
(2R)-N-allyl-2,4-dihydroxy-3,3-dimethylbutanamide
(R)-3-azido-4,4-dimethyl-dihydro-furan-2-one
(R)-4-(2,4-dihydroxy-3,3-dimethyl-butyrylamino)-butyric acid
(R)-4-(2-amino-4-hydroxy-3,3-dimethyl-butyrylamino)-butyric acid
(R)-4-(2-azido-4-hydroxy-3,3-dimethyl-butyrylamino)-butyric acid
(S)-4-(2,4-dihydroxy-3,3-dimethyl-butyrylamino)-butyric acid
(S)-trifluoro-methanesulfonic acid 4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl-ester
1,4-dioxa-8-azaspiro[4.5]dec-8-yl[2-[(3-fluorophenyl)sulfanyl]pyridin-4-yl]methanone
-
mixed non-competitive inhibition
1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea dihydrobromide
-
2'-Ketopantetheine
-
-
2,4-dihydroxy-3,3-dimethyl N-(2-heptylcarbamoyl-ethyl)-butyramide
2,4-dihydroxy-3,3-dimethyl N-(2-isobutylcarbamoyl-ethyl)-butyramide
2,4-dihydroxy-3,3-dimethyl N-(2-pentylcarbamoyl-ethyl)-butyramide
2,4-dihydroxy-3,3-dimethyl N-(2-phenethylcarbamoyl-ethyl)-butyramide
2,4-dihydroxy-3,3-dimethyl N-(2-propylcarbamoylethyl)-butyramide
2,4-dihydroxy-3,3-dimethyl N-(2-[1-methyl-3-phenyl-propylcarbamoyl]-ethyl)-butyramide
2,4-dihydroxy-3,3-dimethyl N-(2-[2-(3,4-dimethoxy-phenyl)-ethylcarbamoyl]-ethyl)-butyramide
2,4-dihydroxy-3,3-dimethyl N-(2-[3,4,5-trimethoxy-benzylcarbamoyl]-ethyl)-butyramide
2,4-dihydroxy-3,3-dimethyl N-[2-(2,6,6-trimethylbicyclo[3.1.1]hept-3-ylcarbamoyl)-ethyl]-butyramide
2,4-dihydroxy-3,3-dimethyl N-[2-(2-ethoxy-ethylcarbamoyl)-ethyl]-butyramide
2,4-dihydroxy-3,3-dimethyl N-[2-(2-ethylsulfanylethylcarbamoyl)-ethyl]-butyramide
2,4-dihydroxy-3,3-dimethyl N-[2-(2-methylsulfanylethylcarbamoyl)-ethyl]-butyramide
2,4-dihydroxy-3,3-dimethyl N-[2-(2-morpholin-4-yl-ethylcarbamoyl)-ethyl]-butyramide
2,4-dihydroxy-3,3-dimethyl N-[2-(3,7-dimethylocta-2,6-dienylcarbamoyl)-ethyl]-butyramide
2,4-dihydroxy-3,3-dimethyl N-[2-(3-ethoxy-propylcarbamoyl)-ethyl]-butyramide
2,4-dihydroxy-3,3-dimethyl N-[2-(3-methylsulfanylpropylcarbamoyl)-ethyl]-butyramide
2,4-dihydroxy-3,3-dimethyl N-[2-(4-methoxy-benzylcarbamoyl)-ethyl]-3,3-dimethyl-butyramide
2,4-dihydroxy-3,3-dimethyl N-[3-(4-benzyl-piperazin-1-yl)-3-oxo-propyl]-butyramide
2,4-dihydroxy-N-[2-(2-hydroxy-ethylcarbamoyl)-ethyl]-3,3-dimethyl-butyramide
2,4-dihydroxy-N-[2-(2-methoxy-ethylcarbamoyl)-ethyl]-3,3-dimethyl-butyramide
2,4-dihydroxy-N-[2-(3-hydroxy-propylcarbamoyl)-ethyl]-3,3-dimethyl-butyramide
2,4-dihydroxy-N-[2-(3-methoxy-propylcarbamoyl)-ethyl]-3,3-dimethyl-butyramide
2,6-difluoro-N-[1-(5-[[2-(4-fluorophenoxy)ethyl]sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl)ethyl]benzamide
-
competitive inhibition
2-chloro-N-[1-(5-[[2-(4-fluorophenoxy)ethyl]sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl)ethyl]benzamide
-
competitive inhibition
2-[(4'-cyano-2-[[4-(pyridin-2-yl)piperazin-1-yl]methyl][1,1'-biphenyl]-4-yl)oxy]-1-oxoethan-1-aminide
-
non-competitive inhibition
2-[2-(1-benzoylpiperidin-4-yl)-5-methyl-1,3-thiazol-4-yl]-N-(4-methylphenyl)acetamide
-
uncompetitive inhibition
4-(2,4-dihydroxy-3,3-dimethylbutylamido)butyric acid
-
competitive inhibitor; competitive inhibitor, IC50: 0.05-0.15 mM
4-phosphopantoate
substrate inhibition
5'-deoxy-5'-(4-(beta-D-galactopyranosyloxymethyl)-1,2,3-triazol-1-yl)adenosine
-
competitive inhibitor with respect to ATP
acetoacetyl-CoA
-
-
acetyl-CoA
Acyl carrier protein
acyl-CoA-esters
Arachidonoyl-CoA
-
-
chloranil
-
CoA esters
-
feedback inhibition, inhibition kinetics of recombinant isozyme mPanK2
coenzyme A
D-pantothenate
-
substrate inhibition, above 0.5 mM
dehydroisoandrosterone
about 30% residual activity at 0.1 mM (isoform PanK3)
Dehydroisoandrosterone sulfate
; about 8% residual activity at 0.1 mM (isoform PanK3)
dephospho-CoA
diphosphate
-
-
ephedrine hydrochloride
-
estradiol
about 80% residual activity at 0.1 mM (isoform PanK3)
Estradiol sulfate
about 90% residual activity at 0.1 mM (isoform PanK3)
Estrone sulfate
about 50% residual activity at 0.1 mM (isoform PanK3)
Fusidic acid
-
glipizide
-
glyburide
-
Hexachlorophene
-
L-Pantothenate
-
-
malonyl-CoA
MCC-555
MCC-555 inhibits all three isoforms with a rank order of PanK3 > PanK2 > PanK1b; MCC-555 inhibits all three isoforms with a rank order of PanK3 > PanK2 > PanK1b
N-(1-[5-[(4-fluorobenzyl)sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl]ethyl)-2-(trifluoromethyl)benzamide
-
competitive inhibition
N-heptylpantothenamide
N-pentylpantothenamide
N-[1-(5-[[2-(4-chlorophenoxy)ethyl]sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl)ethyl]naphthalene-1-carboxamide
-
competitive inhibition
N-[1-(5-[[2-(4-fluorophenoxy)ethyl]sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl)ethyl]-2-(trifluoromethyl)benzamide
-
competitive inhibition
N-[1-(5-[[2-(4-fluorophenoxy)ethyl]sulfanyl]-4-[(4-fluorophenyl)methyl]-4H-1,2,4-triazol-3-yl)ethyl]-2-(trifluoromethyl)benzamide
-
competitive inhibition
Octanoyl-CoA
-
-
oleoyl-CoA
-
-
palmitoyl-CoA
pantetheine 4'-phosphate
pantothenamide, N-substituted
-
IC50 about 0.0004-0.0016 mM
-
pantothenic acid 4'-phosphate
-
-
pantothenol
-
competitive inhibition
pantothenoylcysteine 4'-phosphate
pantothenyl alcohol
-
-
pioglitazone hydrochloride
-
pregnenolone sulfate
; about 10% residual activity at 0.1 mM (isoform PanK3); about 92% residual activity at 0.1 mM (isoform PanK3)
propionyl-CoA
-
-
Psi-rhodomyrtoxin
-
Reactive blue 2
-
Ro 41-0960
-
rosiglitazone
-
succinyl-CoA
-
-
tamoxifen
-
tolfenamic acid
-
tyrphostin AG 528
-
tyrphostin AG 808
-
WIN 62577
-
[(4'-cyano-2-[[4-(pyridin-2-yl)piperazin-1-yl]methyl][1,1'-biphenyl]-4-yl)oxy]acetic acid
-
non-competitive inhibition
[2-[(3-chlorophenyl)sulfanyl]pyridin-4-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
-
mixed non-competitive inhibition
[2-[(3-chlorophenyl)sulfanyl]quinolin-4-yl](piperidin-1-yl)methanone
-
mixed non-competitive inhibition
[[2-[[4-(6-methylpyridin-2-yl)piperazin-1-yl]methyl]-4'-(trifluoromethoxy)biphenyl-4-yl]oxy]acetic acid
-
mixed non-competitive inhibition
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Acyl carrier protein
-
PAK II: inhibition, PAK I: stimulation between 0.015-0.035 mM
cholesterol
about 125% activity at 0.1 mM
CoA
-
stimulates
dithiothreitol
-
activation
glyburide
; isoform PanK1b is activated by glyburide
O-oleoylcarnitine
140% activation at 0.1 mM
O-palmitoylcarnitine
120% activation at 0.1 mM
oleoylethanolamide
120% activation at 0.1 mM
palmitoylcarnitine
tamoxifen
140% activation at 0.1 mM
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[(piperidin-4-yl)methyl]amino]propyl)butanamide
-
at pH 7.6, temperature not specified in the publication
1
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(piperazin-1-yl)ethyl]amino]propyl)butanamide
-
at pH 7.6, temperature not specified in the publication
0.11
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(pyridin-2-yl)ethyl]amino]propyl)butanamide
-
at pH 7.6, temperature not specified in the publication
1.2
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[2-oxo-2-(pentylamino)ethyl]amino]propyl)butanamide
-
at pH 7.6, temperature not specified in the publication
0.35
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[3-(morpholin-4-yl)propyl]amino]-3-oxopropyl)butanamide
-
at pH 7.6, temperature not specified in the publication
0.19
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[(1-pentyl-1H-1,2,3-triazol-4-yl)methyl]butanamide
-
at pH 7.6, temperature not specified in the publication
1
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-(1-propyl-1H-1,2,3-triazol-4-yl)propyl]butanamide
-
at pH 7.6, temperature not specified in the publication
0.036
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pentylamino)propyl]butanamide
-
at pH 7.6, temperature not specified in the publication
0.043
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(phenylamino)propyl]butanamide
-
at pH 7.6, temperature not specified in the publication
0.45
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pyrimidin-4-ylamino)propyl]butanamide
-
at pH 7.6, temperature not specified in the publication
0.032
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(3-phenylpropyl)amino]propyl]butanamide
-
at pH 7.6, temperature not specified in the publication
0.05
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-2-ylmethyl)amino]propyl]butanamide
-
at pH 7.6, temperature not specified in the publication
0.033
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-3-ylmethyl)amino]propyl]butanamide
-
at pH 7.6, temperature not specified in the publication
0.13
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-4-ylmethyl)amino]propyl]butanamide
-
at pH 7.6, temperature not specified in the publication
0.039
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-[(3-methylpyridin-2-yl)amino]-3-oxopropyl]butanamide
-
at pH 7.6, temperature not specified in the publication
0.022
(2R)-2,4-dihydroxy-N-(3-[[3-(1H-imidazol-1-yl)propyl]amino]-3-oxopropyl)-3,3-dimethylbutanamide
-
at pH 7.6, temperature not specified in the publication
0.2
(2R)-N-[3-(1,3-dihydro-2H-isoindol-2-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
-
at pH 7.6, temperature not specified in the publication
0.4
(2R)-N-[3-(2,3-dihydro-1H-indol-1-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
-
at pH 7.6, temperature not specified in the publication
0.067
(2R)-N-[3-(benzylamino)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
-
at pH 7.6, temperature not specified in the publication
0.24
(2R)-N-[3-[(2-butanamidoethyl)amino]-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
-
at pH 7.6, temperature not specified in the publication
0.23
(2S)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-[3-oxo-3-(pentylamino)propyl]pentanamide
-
at pH 7.6, temperature not specified in the publication
0.11
(2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hept-6-ynamide
-
at pH 7.6, temperature not specified in the publication
0.59 - 1.2
(2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hex-5-enamide
0.0057 - 0.168
(R)-pantothenate
0.7
3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]-2-(pentylamino)propanoate
-
at pH 7.6, temperature not specified in the publication
0.027 - 9.59
ATP
1.759
CTP
-
-
0.138
dATP
-
-
0.839
dCTP
-
-
0.117
dGTP
-
-
0.723
dTTP
-
-
668
GTP
-
in citrate buffer, pH 6.5, temperature not specified in the publication
0.225 - 1
MgATP2-
0.008 - 0.124
N-heptylpantothenamide
0.003 - 0.14
N-pentylpantothenamide
0.12
N-[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]-beta-alanyl-N-pentylglycinamide
-
at pH 7.6, temperature not specified in the publication
0.06
pantheteine
-
at pH 7.6, temperature not specified in the publication
-
0.009 - 1.3
pantothenate
0.25 - 0.28
pantothenol
1.715
UTP
-
-
additional information
additional information
-
kinetics of recombinant isozyme mPanK2
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.19
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[(piperidin-4-yl)methyl]amino]propyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.75
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(piperazin-1-yl)ethyl]amino]propyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.15
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(pyridin-2-yl)ethyl]amino]propyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.13
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[2-oxo-2-(pentylamino)ethyl]amino]propyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.03
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[3-(morpholin-4-yl)propyl]amino]-3-oxopropyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.96
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[(1-pentyl-1H-1,2,3-triazol-4-yl)methyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.49
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-(1-propyl-1H-1,2,3-triazol-4-yl)propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.93
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pentylamino)propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.02
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(phenylamino)propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.44
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pyrimidin-4-ylamino)propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.13
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(3-phenylpropyl)amino]propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.02
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-2-ylmethyl)amino]propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.24
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-3-ylmethyl)amino]propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.94
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-4-ylmethyl)amino]propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.78
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-[(3-methylpyridin-2-yl)amino]-3-oxopropyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.46
(2R)-2,4-dihydroxy-N-(3-[[3-(1H-imidazol-1-yl)propyl]amino]-3-oxopropyl)-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.45
(2R)-N-[3-(1,3-dihydro-2H-isoindol-2-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.18
(2R)-N-[3-(2,3-dihydro-1H-indol-1-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.15
(2R)-N-[3-(benzylamino)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.09
(2R)-N-[3-[(2-butanamidoethyl)amino]-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.17
(2S)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-[3-oxo-3-(pentylamino)propyl]pentanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.04
(2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hept-6-ynamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.28 - 0.89
(2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hex-5-enamide
0.29 - 2.12
(R)-pantothenate
0.23
3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]-2-(pentylamino)propanoate
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
0.052 - 2.12
ATP
1.5
CTP
Bacillus anthracis
-
-
0.9
dATP
Bacillus anthracis
-
-
0.5
dCTP
Bacillus anthracis
-
-
0.8
dGTP
Bacillus anthracis
-
-
0.4
dTTP
Bacillus anthracis
-
-
0.064
GTP
Mycobacterium tuberculosis
-
in citrate buffer, pH 6.5, temperature not specified in the publication
0.425
N-heptylpantothenamide
Staphylococcus aureus
-
pH 7.5, 37C, recombinant enzyme
0.15
N-pentylpantothenamide
Staphylococcus aureus
-
pH 7.5, 37C, recombinant enzyme
1.12
N-[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]-beta-alanyl-N-pentylglycinamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
1.03
pantheteine
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
-
0.61 - 0.818
pantothenate
0.38 - 0.4
pantothenol
1.7
UTP
Bacillus anthracis
-
-
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.5
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[(piperidin-4-yl)methyl]amino]propyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214045
0.3
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(piperazin-1-yl)ethyl]amino]propyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214046
11
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-3-[[2-(pyridin-2-yl)ethyl]amino]propyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214031
0.1
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[2-oxo-2-(pentylamino)ethyl]amino]propyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214047
2.9
(2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[3-(morpholin-4-yl)propyl]amino]-3-oxopropyl)butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214039
5.1
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[(1-pentyl-1H-1,2,3-triazol-4-yl)methyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214035
0.5
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-(1-propyl-1H-1,2,3-triazol-4-yl)propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214044
26
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pentylamino)propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214023
24
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(phenylamino)propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214028
3.2
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-(pyrimidin-4-ylamino)propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214041
35
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(3-phenylpropyl)amino]propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214025
20
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-2-ylmethyl)amino]propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214029
38
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-3-ylmethyl)amino]propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214026
7
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-3-[(pyridin-4-ylmethyl)amino]propyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214034
20
(2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-[(3-methylpyridin-2-yl)amino]-3-oxopropyl]butanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214027
21
(2R)-2,4-dihydroxy-N-(3-[[3-(1H-imidazol-1-yl)propyl]amino]-3-oxopropyl)-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214024
1.9
(2R)-N-[3-(1,3-dihydro-2H-isoindol-2-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214036
0.4
(2R)-N-[3-(2,3-dihydro-1H-indol-1-yl)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214040
17
(2R)-N-[3-(benzylamino)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214030
4.5
(2R)-N-[3-[(2-butanamidoethyl)amino]-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214038
5.1
(2S)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-[3-oxo-3-(pentylamino)propyl]pentanamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214037
9
(2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hept-6-ynamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214032
0.2 - 1.5
(2S)-3-ethyl-2-hydroxy-3-(hydroxymethyl)-N-[3-oxo-3-(pentylamino)propyl]hex-5-enamide
214042
50
(R)-pantothenate
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
2630
0.3
3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]-2-(pentylamino)propanoate
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214043
0.08 - 9.91
ATP
4
0.9
CTP
Bacillus anthracis
-
-
60
6.6
dATP
Bacillus anthracis
-
-
140
0.6
dCTP
Bacillus anthracis
-
-
179
6.5
dGTP
Bacillus anthracis
-
-
219
0.5
dTTP
Bacillus anthracis
-
-
145
0.095
GTP
Mycobacterium tuberculosis
-
in citrate buffer, pH 6.5, temperature not specified in the publication
37
10
N-[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]-beta-alanyl-N-pentylglycinamide
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214033
17
pantheteine
Escherichia coli
-
at pH 7.6, temperature not specified in the publication
214022
1
UTP
Bacillus anthracis
-
-
65
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.138 - 0.2
(2R)-2,4-dihydroxy-3,3-dimethyl-N'-phenylbutanohydrazide
0.013
(2R)-2,4-dihydroxy-3,3-dimethylbutanohydrazide
-
37C, versus pantothenate at 1 mM
0.0019
(2R)-2,4-dihydroxy-N-(2-hydroxyethyl)-3,3-dimethylbutanamide
-
37C, versus pantothenate at 1 mM
4
(2R)-N-(2,3-dihydroxypropyl)-2,4-dihydroxy-3,3-dimethylbutanamide
-
37C, versus pantothenate at 1 mM
0.082 - 1
(2R)-N-allyl-2,4-dihydroxy-3,3-dimethylbutanamide
0.162
2,4-dihydroxy-3,3-dimethyl N-(2-pentylcarbamoyl-ethyl)-butyramide
-
37C, versus pantothenate at 1 mM
0.112
2,4-dihydroxy-3,3-dimethyl N-(2-propylcarbamoylethyl)-butyramide
-
37C, versus pantothenate at 1 mM
0.111
2,4-dihydroxy-3,3-dimethyl N-[2-(3-ethoxy-propylcarbamoyl)-ethyl]-butyramide
-
37C, versus pantothenate at 1 mM
0.076
2,4-dihydroxy-3,3-dimethyl N-[2-(3-methylsulfanylpropylcarbamoyl)-ethyl]-butyramide
-
37C, versus pantothenate at 1 mM
0.109
2,4-dihydroxy-N-[2-(3-methoxy-propylcarbamoyl)-ethyl]-3,3-dimethyl-butyramide
-
37C, versus pantothenate at 1 mM
0.164
5'-deoxy-5'-(4-(beta-D-galactopyranosyloxymethyl)-1,2,3-triazol-1-yl)adenosine
-
-
0.002 - 0.067
CoA
0.037
pantetheine 4'-phosphate
-
pH 6.5, 37C
0.125
pantothenic acid 4'-phosphate
-
pH 6.5, 37C
0.129
pantothenol
-
37C, versus pantothenate at 1 mM
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0084
1,4-dioxa-8-azaspiro[4.5]dec-8-yl[2-[(3-fluorophenyl)sulfanyl]pyridin-4-yl]methanone
Mycobacterium tuberculosis
-
in 50 mM PIPES-NaOH (pH 7.0), 25 mM KCl, 20 mM MgCl, at 25C
0.0004
1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea dihydrobromide
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37C
0.00257
2-[2-(1-benzoylpiperidin-4-yl)-5-methyl-1,3-thiazol-4-yl]-N-(4-methylphenyl)acetamide
Mycobacterium tuberculosis
-
in 50 mM PIPES-NaOH (pH 7.0), 25 mM KCl, 20 mM MgCl, at 25C
0.05 - 0.15
4-(2,4-dihydroxy-3,3-dimethylbutylamido)butyric acid
Mus musculus
-
competitive inhibitor, IC50: 0.05-0.15 mM
0.00006 - 0.000125
acetyl-CoA
0.0059
chloranil
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37C
0.2
CoA
Plasmodium falciparum
-
IC50: 0.2 mM
0.0035
Dehydroisoandrosterone sulfate
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37C
0.0016
ephedrine hydrochloride
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37C
0.0001
Fusidic acid
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37C
0.0052
glipizide
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37C
0.0068
glyburide
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37C
0.0092
GW5074
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37C
0.0088
Hexachlorophene
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37C
0.0048
N-heptylpantothenamide
Staphylococcus aureus
-
IC50 is 0.0048 mM, potent growth inhibitory anti-metabolite
0.0035
N-pentylpantothenamide
Staphylococcus aureus
-
IC50 is 0.0035 mM, has antimicrobial activity against Staphylococcus aureus
0.00007
N-[1-(5-[[2-(4-chlorophenoxy)ethyl]sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl)ethyl]naphthalene-1-carboxamide
Mycobacterium tuberculosis
-
in 50 mM PIPES-NaOH (pH 7.0), 25 mM KCl, 20 mM MgCl, at 25C
0.0004 - 0.0016
pantothenamide, N-substituted
Staphylococcus aureus
-
IC50 about 0.0004-0.0016 mM
-
0.001
pioglitazone hydrochloride
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37C
0.0025
pregnenolone sulfate
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37C
0.0016
Psi-rhodomyrtoxin
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37C
0.0013
Reactive blue 2
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37C
0.0039
Ro 41-0960
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37C
0.0017
rosiglitazone
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37C
0.0092
tolfenamic acid
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37C
0.003
tyrphostin AG 528
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37C
0.009
tyrphostin AG 808
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37C
0.0007
WIN 62577
Homo sapiens
Q9H999
isoform PanK3, at pH 7.5 and 37C
0.00024 - 0.00042
[2-[(3-chlorophenyl)sulfanyl]pyridin-4-yl][4-(hydroxymethyl)piperidin-1-yl]methanone
0.00087
[2-[(3-chlorophenyl)sulfanyl]quinolin-4-yl](piperidin-1-yl)methanone
Mycobacterium tuberculosis
-
in 50 mM PIPES-NaOH (pH 7.0), 25 mM KCl, 20 mM MgCl, at 25C
0.00082
[[2-[[4-(6-methylpyridin-2-yl)piperazin-1-yl]methyl]-4'-(trifluoromethoxy)biphenyl-4-yl]oxy]acetic acid
Mycobacterium tuberculosis
-
in 50 mM PIPES-NaOH (pH 7.0), 25 mM KCl, 20 mM MgCl, at 25C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0002421
-
0.045 mM pantothenate, 0.25 mM ATP (pH 7.0), 10 mM MgCl2, 0.1 M Tris/HCl (pH 7.5), at 37C
0.0012
-
pH 6.1, 37C
0.00171
-
pH 7.0, 37C
0.0041
-
pH 6.1, 37C
0.034
-
pH 6.5, 37C
0.152
-
isoform 1, 37C, pH 8.0
0.36
purified recombinant protein
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.9 - 6.3
-
-
6 - 9
-
broad, highest activity in 50 mM phosphate buffer
7
-
assay at
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4.5 - 6
more than 70% of the maximum activity
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
15
the enzyme has no activity at temperatures below 15C
30 - 42
-
-
50 - 70
more than 80% of the maximum activity
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.1
-
isoelectric focusing, isoform B
5.7
-
isoelectric focusing, isoform A
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
LOCALIZATION
ORGANISM